KR102236784B1 - 성장 호르몬 수용체의 조절인자 - Google Patents

성장 호르몬 수용체의 조절인자 Download PDF

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KR102236784B1
KR102236784B1 KR1020167001790A KR20167001790A KR102236784B1 KR 102236784 B1 KR102236784 B1 KR 102236784B1 KR 1020167001790 A KR1020167001790 A KR 1020167001790A KR 20167001790 A KR20167001790 A KR 20167001790A KR 102236784 B1 KR102236784 B1 KR 102236784B1
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산제이 바놋
수잔 엠. 프레이어
후인-호아 부이
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아이오니스 파마수티컬즈, 인코포레이티드
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Abstract

본 구현예는 성장 호르몬 수용체 (GHR)에 대해 표적화된 안티센스 화합물 또는 올리고뉴클레오타이드를 사용하여 과잉의 성장 호르몬과 연관된 질환을 치료, 예방, 또는 개선하는 방법, 화합물, 및 조성물을 제공한다.

Description

성장 호르몬 수용체의 조절인자{MODULATORS OF GROWTH HORMONE RECEPTOR}
본 구현예는 성장 호르몬 수용체 (GHR)에 대해 표적화된 안티센스 화합물 또는 올리고뉴클레오타이드를 사용하여 과잉의 성장 호르몬과 연관된 질환을 치료, 예방, 또는 개선하는 방법, 화합물, 및 조성물을 제공한다.
서열 목록
본 출원은 전자 포맷의 서열목록과 함께 출원된다. 상기 서열 목록은 크기가 1028 kb이고 2014년 6월 30일자로 작성된 BIOL0226WOSEQ_ST25.txt 파일명으로 제공된다. 상기 서열 목록의 전자 포맷에서의 정보는 이의 전문이 본원에 참조로서 인용된다.
성장 호르몬은 뇌하수체에서 생산되고 혈류로 분비되어 여기서, 상기 호르몬은 많은 세포 유형상의 성장 호르몬 수용체(GHR)에 결합하고 인슐린형 성장 인자-1(IGF-1)의 생성을 유발한다. IGF-1은 주로 간에서 생성되지만 또한 지방 조직 및 신장에서 생성되어 혈류로 분비된다. 말단 비대증 및 거인증과 같은 여러 장애는 혈장 및/또는 조직에서 상승된 성장 호르몬 수준 및/또는 상승된 IGF-I 수준과 관련된다.
성장 호르몬의 과도한 생성은 말단 비대증 또는 거인증과 같은 질환을 유발할 수 있다. 말단 비대증 및 거인증은 흔히 뇌하수체 종양에 의해 유발되는 과도한 성장 호르몬과 관련되고 전세계적으로 100만의 인구당 40-50명에 영향을 미치고 미국 및 유럽 각각에서 약 15,000명의 환자가 있고 연간 100만 인구 당 약 4-5건이 발병한다. 말단 비대증 및 거인증은 초기에 외모의 특징상 손과 발의 비정상적 성장 및 골질 변화를 특징으로 한다. 성장과 관련된 많은 결과들은 혈청 IGF-1의 상승된 수준에 의해 매개된다.
요약
본원에 제공된 구현예는 과도한 성장 호르몬과 관련된 질환을 치료하거나 예방하거나 완화시키기 위한 방법, 화합물 및 조성물에 관한 것이다. 본원에 제공된 여러 구현예는 성장 호르몬 수용체(GHR)에 표적화된 안티센스 화합물 또는 올리고뉴클레오타이드에 대한 것이다. 여러 구현예는 성장 호르몬 수용체(GHR)에 표적화된 안티센스 화합물 또는 올리고뉴클레오타이드를 사용하여 말단 비대증의 치료, 예방 또는 완화에 관한 것이다.
발명의 상세한 설명
이전의 일반 기재 및 하기의 상세한 설명은 단지 예시적이고 설명을 위한 것이고 청구된 바와 같은 발명을 제한하지 않는 것으로 이해되어야만 한다. 본원에서 단수의 사용은 특별히 달리 진술되지 않는 경우 복수를 포함한다. 본원에 사용된 바와 같은 "또는"의 사용은 달리 진술되지 않는 경우 "및/또는"을 의미한다. 추가로, "포함한다" 및 "포함된"과 같은 다른 형태 뿐만 아니라 용어 "포함하는"의 사용은 제한하지 않는다. 또한, "요소" 또는 "성분"과 같은 용어는 특별히 달리 특정되지 않는 경우 하나의 유니트를 포함하는 요소 및 성분 둘다 및 하나 이상의 서브유니트를 포함하는 요소 및 성분을 포괄한다.
본원에 사용된 섹션 표제는 단지 구성적 목적을 위한 것이고 기재된 주요 요지를 제한하는 것으로서 해석되지 말아야 한다. 특허, 특허 출원, 잡지, 책 및 논문을 포함하지만 이에 제한되지 않는 모든 서류 또는 서류의 일부는 이들의 전문 뿐만 아니라 본원에서 논의된 서류의 일부에 대해 명백히 참조로 인용된다.
달리 지시되지 않는 경우, 하기의 용어는 하기의 의미를 갖는다:
"2'-O-메톡시에틸" (또한 2'-MOE 및 2'-O(CH2)2-OCH3)는 푸라노스 환의 2' 위치에 O-메톡시-에틸 변형을 언급한다. 2'-O-메톡시에틸 변형된 당은 변형된 당이다.
"2'-MOE 뉴클레오사이드" (또한 2'-O-메톡시에틸 뉴클레오사이드)는 2'-MOE 변형된 당 잔기를 포함하는 뉴클레오사이드를 의미한다.
"2'-치환된 뉴클레오사이드"는 푸라노실 환의 2' 위치에서 H 또는 OH 이외에 다른 치환체를 포함하는 뉴클레오사이드를 의미한다. 특정 구현예에서, 2' 치환된 뉴클레오사이드는 바이사이클릭 당 변형을 갖는 뉴클레오사이드를 포함한다.
"3' 표적 부위"는 특정 안티센스 화합물의 3'-최외각 뉴클레오타이드에 상보적인 표적 핵산의 뉴클레오타이드를 언급한다.
"5' 표적 부위"는 특정 안티센스 화합물의 5'-최외각 뉴클레오타이드에 상보적인 표적 핵산의 뉴클레오타이드를 언급한다.
"5-메틸사이토신"은 5 위치에 부착된 메틸 그룹으로 변형된 사이토신을 의미한다. 5-메틸사이토신은 변형된 뉴클레오염기이다.
"약"은 값의 ±10% 이내를 의미한다. 예를 들어, "화합물이 GHR의 적어도 약 70% 억제에 영향을 미쳤다"가 진술되는 경우 이것은 GHR 수준이 60% 및 80% 범위내에서 억제됨을 의미한다.
"투여" 또는 "투여하는"은 이의 의도된 기능을 수행하기 위해 본원에 제공된 안티센스 화합물을 대상체에 도입하는 경로를 언급한다. 사용될 수 있는 투여 경로의 예는 피하, 정맥내 또는 근육내 주사 또는 주입과 같은 비경구 투여를 포함하지만 이에 제한되지 않는다.
"완화"는 관련된 질환, 장애 또는 병태의 하나 이상의 징후, 조짐 또는 증상의 감소를 언급한다. 특정 구현예에서, 완화는 병태 또는 질환의 하나 이상의 징후의 진행을 지연시키거나 느리게하는 것을 포함한다. 징후의 중증도는 당업자에게 공지된 주관적 또는 객관적 측정에 의해 결정할 수 있다.
"동물"은 사람, 또는 마우스, 랫트, 토끼, 개, 고양이, 돼지 및 몽키 및 침팬지를 포함하지만 이에 제한되지 않는 비-사람 영장류를 포함하지만 이에 제한되지 않는 비-사람 동물을 언급한다.
"안티센스 활성"은 이의 표적 핵산으로 안티센스 화합물의 하이브리드화에 기인할 수 있는 임의의 검출가능하거나 측정가능한 활성을 의미한다. 특정 구현예에서, 안티센스 활성은 표적 핵산 또는 상기 표적 핵산에 의해 암호화된 단백질의 양 또는 발현에서의 감소이다.
"안티센스 화합물"은 수소 결합을 통해 표적 핵산에 하이브리드화를 진행할 수 있는 올리고머성 화합물을 의미한다. 안티센스 화합물의 예는 안티센스 올리고뉴클레오타이드, siRNA, shRNAs, ssRNA, 및 점유 기반 화합물과 같은 단일 가닥 및 이중 가닥의 화합물을 포함한다.
"안티센스 억제"는 안티센스 화합물의 부재하의 표적 핵산 수준과 비교하여, 표적 핵산에 상보적인 안티센스 화합물의 존재하의 표적 핵산 수준의 감소를 의미한다.
"안티센스 기작"은 표적 핵산과의 화합물의 하이브리드화를 포함하는 모든 상기 기작이고, 여기서, 하이브리드화의 결과 또는 효과는 예를 들어, 전사 또는 스플라이싱을 포함하는 세포 기구를 동시에 정지시킴과 함께 표적 분해 또는 표적 점유이다.
"안티센스 올리고뉴클레오타이드"는 표적 핵산의 상응하는 영역 또는 절편에 대한 하이브리드화를 가능하게 하는 뉴클레오염기 서열을 갖는 단일 가닥의 올리고뉴클레오타이드를 의미한다.
"염기 상보성"은 표적 핵산에서 상응하는 뉴클레오염기와 안티센스 올리고뉴클레오타이드의 뉴클레오염기의 정확한 염기쌍 형성(즉, 하이브리드화)에 대한 능력을 언급하고 상응하는 뉴클레오염기간에 왓슨-크릭, 후그스틴 또는 역 후그스틴 수소 결합에 의해 매개된다.
"바이사이클릭 당 잔기"는 제2 환을 형성하여 바이사이클릭 구조를 유도하는 4 내지 7원 환(푸라노실을 포함하지만 이에 제한되지 않는다)의 2개의 원자를 연결하는 브릿지를 포함하는 4 내지 7원 환을 포함하는 변형된 당 잔기를 의미한다. 특정 구현예에서, 상기 4 내지 7원 환은 당 환이다. 특정 구현예에서, 상기 4 내지 7원 환은 푸라노실이다. 특정 상기 구현예에서, 상기 브릿지는 푸라노실의 2' 탄소 및 4' 탄소를 연결한다.
"바이사이클릭 핵산" 또는 "BNA" 또는 "BNA 뉴클레오사이드"는 뉴클레오사이드 당 유니트의 4'와 2' 위치간에 2개의 탄소 원자를 연결하여 바이사이클릭 당을 형성하는 브릿지를 갖는 핵산 단량체를 의미한다. 상기 바이사이클릭 당의 예는 하기된 바와 같이 A) α-L-메틸렌옥시 (4'-CH2-O-2') LNA, (B) β-D-메틸렌옥시 (4'-CH2-O-2') LNA, (C) 에틸렌옥시 (4'-(CH2)2-O-2') LNA, (D) 아미노옥시 (4'-CH2-O-N(R)-2') LNA 및 (E) 옥시아미노 (4'-CH2-N(R)-O-2') LNA를 포함하지만 이에 제한되지 않는다.
Figure 112016006891241-pct00001
본원에 사용된 바와 같이, LNA 화합물은 상기 당의 4' 및 2' 위치간에 하나 이상의 브릿지를 갖는 화합물을 포함하지만 이에 제한되지 않고, 여기서, 상기 브릿지 각각은 독립적으로 -[C(R1)(R2)]n-, -C(R1)=C(R2)-, -C(R1)=N-, -C(=NR1)-, -C(=O)-, -C(=S)-, -O-, -Si(R1)2-, -S(=O)x- 및 -N(R1)-로 부터 독립적으로 선택되는 1개 또는 2 내지 4개의 연결 그룹을 포함하고; 여기서: X는 0, 1, 또는 2이고; n은 1, 2, 3, 또는 4이고; 각각의 R1 및 R2는 독립적으로 H, 보호 그룹, 하이드록실, C1-C12 알킬, 치환된 C1-C12 알킬, C2-C12 알케닐, 치환된 C2-C12 알케닐, C2-C12 알키닐, 치환된 C2-C12 알키닐, C5-C20 아릴, 치환된 C5-C20 아릴, 헤테로사이클 라디칼, 치환된 헤테로사이클 라디칼, 헤테로아릴, 치환된 헤테로아릴, C5-C7 알리사이클릭 라디칼, 치환된 C5-C7 알리사이클릭 라디칼, 할로겐, OJ1, NJ1J2, SJ1, N3, COOJ1, 아실 (C(=O)-H), 치환된 아실, CN, 설포닐 (S(=O)2-J1), 또는 설폭실 (S(=O)-J1)이고; 각각의 J1 및 J2는 독립적으로, H, C1-C12 알킬, 치환된 C1-C12 알킬, C2-C12 알케닐, 치환된 C2-C12 알케닐, C2-C12 알키닐, 치환된 C2-C12 알키닐, C5-C20 아릴, 치환된 C5-C20 아릴, 아실 (C(=O)-H), 치환된 acyl, 헤테로사이클 라디칼, 치환된 헤테로사이클 라디칼, C1-C12 아미노알킬, 치환된 C1-C12 아미노알킬 또는 보호 그룹이다.
LNA의 정의 내에 포괄되는 4'-2' 브릿징 그룹의 예는 하기식 중 하나를 포함하지만 이에 제한되지 않는다: -[C(R1)(R2)]n-, -[C(R1)(R2)]n-O-, -C(R1R2)-N(R1)-O- 또는 -C(R1R2)-O-N(R1)-. 추가로, LNA의 정의내에 포괄되는 다른 브릿징 그룹은 4'-CH2-2', 4'-(CH2)2-2', 4'-(CH2)3-2', 4'-CH2-O-2', 4'-(CH2)2-O-2', 4'-CH2-O-N(R1)-2' 및 4'-CH2-N(R1)-O-2'- 브릿지이고, 여기서, 각각의 R1 및 R2 은 독립적으로, H, 보호 그룹 또는 C1-C12 알킬이다.
또한 본 발명에 따른 LNA의 정의내에 포함되는 것은 리보실 당 환의 2'-하이드록실 그룹이 당 환의 4' 탄소 원자에 연결되어 바이사이클릭 당 잔기를 형성하기 위한 메틸렌옥시 (4'-CH2-O-2') 브릿지를 형성하는 LNA이다. 상기 브릿지는 또한 2' 산소 원자 및 4' 탄소 원자를 연결하는 메틸렌 (-CH2-) 그룹일 수 있고 이를 위해 용어 메틸렌 옥시 (4'-CH2-O-2') LNA가 사용된다. 추가로 상기 위치에서 에틸렌 브릿징 그룹을 갖는 바이사이클릭 당 잔기의 경우에, 용어 에틸렌옥시 (4'-CH2CH2-O-2') LNA가 사용된다. α-L-메틸렌옥시 (4'-CH2-O-2'), 메틸렌옥시 (4'-CH2-O-2') LNA의 이성체는 또한 본원에 사용된 바와 같은 LNA의 정의내에 포괄된다.
"캡 구조" 또는 "말단 캡 잔기"는 안티센스 화합물의 말단에 도입된 화학적 변형을 의미한다.
"cEt" 또는 "속박된 에틸"은 4'-탄소와 2'-탄소를 연결하는 브릿지를 포함하는 바이사이클릭 당 잔기를 의미하고, 여기서, 상기 브릿지는 하기 화학식을 갖는다: 4'-CH(CH3)-O-2'.
"속박된 에틸 뉴클레오사이드" (또한 cEt 뉴클레오사이드)는 4'-CH(CH3)-O-2' 브릿지를 포함하는 바이사이클릭 당 잔기를 포함하는 뉴클레오사이드를 의미한다.
"화학적으로 두드러진 영역"은 일부 방식에서 동일한 안티센스 화합물의 또 다른 영역과는 화학적으로 상이한 안티센스 화합물의 영역을 언급한다. 예를 들어, 2'-O-메톡시에틸 뉴클레오타이드를 갖는 영역은 2'-O-메톡시에틸 변형 없이 뉴클레오타이드를 갖는 영역과는 화학적으로 구분된다.
"키메라 안티센스 화합물"은 각각의 위치에서 다수의 서브유니트를 갖는 적어도 2개의 화학적으로 구분된 영역을 갖는 안티센스 화합물을 의미한다.
"상보성"은 제1 핵산과 제2 핵산의 뉴클레오염기간의 쌍 형성 능력을 의미한다.
"포함한다(Comprise)", "포함한다(comprises)" 및 "포함하는"은 진술된 단계 또는 요소 또는 단계들 또는 요소들의 그룹을 내포함을 의미하고 임의의 다른 단계 또는 요소 또는 단계들 또는 요소들 그룹을 배제하지 않는 것으로 이해된다.
"연속 뉴클레오염기"는 서로 바로 인접한 뉴클레오염기를 의미한다.
"데옥시리보뉴클레오타이드"는 뉴클레오타이드의 당 부분의 2' 위치에서 수소를 갖는 뉴클레오타이드를 의미한다. 데옥시리보뉴클레오타이드는 임의의 다양한 치환체로 변형될 수 있다.
"디자인하는" 또는 "로 디자인된"은 선택된 핵산 분자와 특이적으로 하이브리드화하는 올리고머 화합물을 디자인하는 과정을 언급한다.
"유효량"은 제제를 필요로 하는 개체에서 목적하는 생리학적 결과를 수행하기에 충분한 활성 약제학적 제제의 양을 의미한다. 상기 유효량은 개체 중에서 치료될 개체의 건강 및 육체적 조건, 치료될 개체의 분류학적 그룹, 조성물의 제형, 개체의 의학적 병태의 평가 및 다른 적절한 인자에 따라 다양할 수 있다.
"효능"은 목적하는 효과를 생성하는 능력을 의미한다.
"발현"은 유전자의 암호화된 정보가 세포에 존재하고 작동하는 구조물로 전환되도록 하는 모든 기능을 포함한다. 상기 구조는 전사 및 해독의 생성물을 포함하지만 이에 제한되지 않는다.
"완전히 상보적" 또는 "100% 상보적"은 제1 핵산의 각각의 뉴클레오염기가 제2 핵산에서 상보적인 뉴클레오염기를 가짐을 의미한다. 특정 구현예에서, 제1 핵산은 안티센스 화합물이고 표적 핵산은 제2 핵산이다.
"갭머(Gapmer)"는 RNase H 절단을 지지하는 다수의 뉴클레오사이드를 갖는 내부 영역이 하나 이상의 뉴클레오사이드를 갖는 외부 영역 사이에 위치하고, 상기 내부 영역을 포함하는 뉴클레오사이드가 외부 영역을 포함하는 뉴클레오사이드 또는 뉴클레오사이드들로부터 화학적으로 구분된 키메라 안티센스 화합물을 의미한다. 상기 내부 영역은 "갭"으로서 언급될 수 있고 상기 외부 영역은 "윙"으로서 언급될 수 있다.
"성장 호르몬 수용체 (GHR)"은 GHR의 임의의 핵산 또는 단백질을 의미한다. "GHR 핵산"은 GHR을 암호화하는 임의의 핵산을 의미한다. 예를 들어, 특정 구현예에서, GHR 핵산은 비-단백질 암호화 (즉 비-암호화) RNA 서열 및 GHR을 암호화하는 mRNA 서열을 포함하는, GHR을 암호화하는 DNA 서열, GHR을 암호화하는 DNA(인트론 및 엑손을 포함하는 게놈 DNA를 포함하는)로부터 전사된 RNA 서열을 포함한다. "GHR mRNA"는 GHR 단백질을 암호화하는 mRNA를 의미한다.
"GHR 특이적 억제제"는 분자 수준에서 GHR RNA 및/또는 GHR 단백질 발현 또는 활성을 특이적으로 억제할 수 있는 임의의 제제를 언급한다. 예를 들어, GHR 특이적 억제제는 핵산(안티센스 화합물을 포함하는), 펩타이드, 소분자 및 GHR RNA 및/또는 GHR 단백질의 발현을 억제할 수 있는 다른 제제를 포함한다.
"하이브리드화"는 상보적 핵산 분자의 어닐링을 의미한다. 특정 구현예에서, 상보적 핵산 분자는 안티센스 화합물 및 핵산 표적물을 포함하지만 이에 제한되지 않는다. 특정 구현예에서, 상보적 핵산 분자는 안티센스 올리고뉴클레오타이드 및 핵산 표적물을 포함하지만 이에 제한되지 않는다.
"질환, 장애 및/또는 병태를 갖는 동물, 또는 가질 위험에 처한 동물을 동정하는"것은 질환, 장애 및/또는 병태로 진단된 동물을 동정하거나 질환, 장애 및/또는 병태를 발병할 성향을 갖는 동물을 동정함을 의미한다. 상기 동정은 개체의 의학적 병력을 평가하고 표준 임상 시험 또는 평가를 포함하는 임의의 방법에 의해 성취될 수 있다.
"바로 인접한"은 바로 인접한 요소들 사이에 어떠한 개입 요소들이 없음을 의미한다.
"개체"는 치료 또는 치료요법을 위해 선택된 사람 또는 비-사람 동물을 의미한다.
"발현 또는 활성을 억제하는"은 발현 또는 활성의 감소, 차단을 언급하고 발현 또는 활성의 완??판 제거를 반드시 지적하지는 않는다.
"뉴클레오사이드 상호 연결"은 뉴클레오사이드간에 화학적 결합을 언급한다.
"길어진" 안티센스 올리고뉴클레오타이드는 본원에 기재된 안티센스 올리고뉴클레오타이드에 상대적으로 하나 이상의 추가의 뉴클레오사이드를 갖는 것들이다.
"연결된 올리고뉴클레오사이드"는 포스페이트 에스테르에 의해 연결된 데옥시리보스에 의해 치환되어 뉴클레오타이드를 형성하는 핵산 염기 (A, G, C, T, U)를 의미한다.
"연결된 뉴클레오사이드"는 뉴클레오사이드 상호 연결에 의해 연결된 인접한 뉴클레오사이드를 의미한다.
"미스매치" 또는 "비-상보적 뉴클레오염기"는 제1 핵산의 뉴클레오염기가 제2 또는 표적 핵산의 상응하는 뉴클레오염기와 쌍을 형성할 수 없는 경우를 언급한다.
"변형된 뉴클레오사이드 상호 연결"은 전연의 뉴클레오사이드 상호 결합(즉, 포스포디에스테르 뉴클레오사이드 상호 결합)으로부터 치환 또는 임의의 변화를 언급한다.
"변형된 뉴클레오염기"는 아데닌, 사이토신, 구아닌, 티미딘 또는 우라실 이외의 임의의 뉴클레오염기를 의미한다. "비변형된 뉴클레오염기"는 퓨린 염기인 아데닌(A) 및 구아닌 (G) 및 피리미딘 염기인 티민(T), 사이토신(C) 및 우라실(U)을 의미한다.
"변형된 뉴클레오사이드"는 독립적으로 변형된 당 잔기 및/또는 변형된 뉴클레오염기를 갖는 뉴클레오사이드를 의미한다.
"변형된 뉴클레오타이드"는 독립적으로 변형된 당 잔기, 변형된 뉴클레오사이드 상호 연결 또는 변형된 뉴클레오염기를 갖는 뉴클레오타이드를 의미한다.
"변형된 올리고뉴클레오타이드"는 적어도 하나의 변형된 뉴클레오사이드 상호 연결, 변형된 당 및/또는 변형된 뉴클레오염기를 포함하는 올리고뉴클레오타이드를 의미한다.
"변형된 당"은 천연 당 잔기로부터의 치환 및/또는 임의의 변화를 의미한다.
"조절"은 세포, 조직, 기관 또는 유기체에서 특징을 변화시키거나 조정하는 것을 언급한다. 예를 들어, GHR mRNA를 조절하는 것은 세포, 조직, 기관 또는 유기체에서 GHR mRNA 및/또는 GHR 단백질의 수준을 증가시키거나 감소시키는 것을 의미할 수 있다. "조절 인자"는 세포, 조직, 기관 또는 유기체에서 변화를 수행한다. 예를 들어, GHR 안티센스 화합물은 세포, 조직, 기관 또는 유기체에서 GHR mRNA 및/또는 GHR 단백질의 양을 감소시키는 조절인자일 수 있다.
"단량체"는 올리고머의 단일 유니트를 언급한다. 단량체는 천연에 존재하거나 변형된 것이든 상관없이 뉴클레오사이드 및 뉴클레오타이드를 포함하지만 이에 제한되지 않는다.
"모티프"는 안티센스 화합물에서 비변형되고 변형된 뉴클레오사이드의 패턴을 의미한다.
"천연 당 잔기"는 DNA (2'-H) 또는 RNA (2'-OH)에서 발현된 당 잔기를 의미한다.
"천연적으로 존재하는 뉴클레오사이드 상호 연결은 3'에서 5'의 포스포디에스테르 연결을 의미한다.
"비-상보적 뉴클레오염기"는 서로간에 수소 결합을 형성하지 않거나 하이브리드화를 지지하지 않는 뉴클레오염기 쌍을 언급한다.
"핵산"은 단량체성 뉴클레오타이드로 구성된 분자를 언급한다. 핵산은 리보핵산 (RNA), 데옥시리보핵산 (DNA), 단일가닥 핵산 및 이중가닥 핵산을 포함하지만 이에 제한되지 않는다.
"뉴클레오염기"는 또 다른 핵산의 염기와 쌍을 형성할 수 있는 헤테로사이클릭 잔기를 의미한다.
"뉴클레오염기 상보성"은 또 다른 뉴클레오염기와 염기 쌍을 형성할 수 있는 뉴클레오염기를 언급한다. 예를 들어, DNA에서, 아데닌 (A)은 티민 (T)에 상보적이다. 예를 들어, RNA에서, 아데닌 (A)은 우라실 (U)에 상보적이다. 특정 구현예에서, 상보적 뉴클레오염기는 이의 표적 핵산의 뉴클레오염기와 염기 쌍을 형성할 수 있는 안티센스 화합물의 뉴클레오염기를 언급한다. 예를 들어, 안티센스 화합물의 특정 위치에서 뉴클레오염기가 표적 핵산의 특정 위치에서 뉴클레오염기와 수소 결합할 수 있는 경우, 올리고뉴클레오타이드와 표적 핵산간의 수소 결합의 위치는 상기 뉴클레오염기 쌍에서 상보적인 것으로 고려된다.
"뉴클레오염기 서열"은 임의의 당, 연결 및/또는 뉴클레오염기 변형과는 무관한 연속 뉴클레오염기 배열을 의미한다.
"뉴클레오사이드"는 당에 연결된 뉴클레오염기를 의미한다.
"뉴클레오사이드 모사체"는 당 또는 당 및 염기를 대체하기 위해 사용되는 상기 구조체를 포함하고 예를 들어, 모르폴리노, 사이클로헥세닐, 사이클로헥실, 테트라하이드로피라닐, 바이사이클로 또는 트리사이클로를 갖는 뉴클레오사이드 모사체, 당 모사체, 예를 들어, 비-푸라노스 당 유니트와 같은 올리고머 화합물의 하나 이상의 위치에서 필연적으로 연결체를 포함하지 않는다. 뉴클레오사이드 모사체는, 예를 들어, 펩타이드 핵산 또는 모르폴리노 (-N(H)-C(=O)-O- 또는 다른 비-포스포디에스테르 연결체에 의해 연결된 모르폴리노)와 같은 올리고머 화합물의 하나 이상의 위치에서 뉴클레오사이드 및 연결체를 대체하기 위해 사용되는 상기 구조체를 포함한다. 당 대용물은 약간 광범위한 용어의 뉴클레오사이드 모사체와 중복되지만 단지 당 유니트(푸라노스 환)의 대체를 지적하는 것으로 의도된다. 본원에 제공된 테트라하이드로피라닐 환은 푸라노스 당 그룹이 테트라하이드로피라닐 환 시스템으로 대체된 당 대용물을 예시한다. "모사체"는 당, 뉴클레오염기 및/또는 뉴클레오사이드 상호 연결체를 치환하는 그룹을 언급한다. 일반적으로, 모사체는 당 또는 당-뉴클레오사이드 상호 연결체 조합 대신 사용되고, 상기 뉴클레오염기는 선택된 표적물로의 하이브리드화를 위해 유지된다.
"뉴클레오타이드"는 뉴클레오사이드의 당 부분에 공유적으로 연결된 포스페이트 그룹을 갖는 뉴클레오사이드를 의미한다.
"올리고머 화합물"은 핵산 분자의 적어도 한 영역에 하이브리드화할 수 있는 연결된 단량체 서브유니트의 중합체를 의미한다.
"올리고뉴클레오사이드"는 뉴클레오사이드 상호 연결체가 인 원자를 함유하지 않는 올리고뉴클레오타이드를 의미한다.
"올리고뉴클레오타이드"는 각각이 서로 무관하게 변형되거나 비변형될 수 있는 연결된 뉴클레오사이드의 중합체를 의미한다.
"비경구 투여"는 주사 또는 주입을 통한 투여를 의미한다. 비경구 투여는 피하 투여, 정맥내 투여, 근육내 투여, 동맥내 투여, 복강내 투여 또는 두개내 투여, 예를 들어, 척추강내 또는 뇌심실내 투여를 포함한다.
"약제학적 조성물"은 개체에 투여하기 위해 적합한 물질의 혼합물을 의미한다. 예를 들어, 약제학적 조성물은 하나 이상의 활성 약제학적 제제 및 멸균 수용액을 포함할 수 있다.
"약제학적으로 허용되는 염"은 안티센스 화합물의 생리학적으로 및 약제학적으로 허용되는 염, 즉, 모 올리고뉴클레오타이드의 목적하는 생물학적 활성을 보유하고 여기에 목적하지 않은 독성 효과를 부여하지 않는 염을 의미한다.
"포스포로티오에이트 연결체"는 포스포디에스테르 결합이 비-브릿징 산소 원자 중 하나가 황 원자로 대체됨에 의해 변형된 뉴클레오사이드 간의 연결체를 의미한다. 포스포로티오에이트 연결체는 변형된 뉴클레오사이드 상호 연결체이다.
"부분"은 한정된 수의 핵산의 연속(즉, 연결된) 뉴클레오염기를 의미한다. 특정 구현예에서, 부분은 한정된 수의 표적 핵산의 연속 뉴클레오염기이다. 특정 구현예에서, 부분은 한정된 수의 안티센스 화합물의 연속 뉴클레오염기이다.
"예방하다"는 분 단위에서 무한 단위의 기간 동안 질환, 장애 또는 병태의 개시, 발병 또는 진행을 지연시키거나 미연에 방지함을 언급한다. 예방하다는 또한 질환, 장애 또는 병태의 위험을 감소시키는 것을 의미한다.
"예방학적 유효량"은 동물에게 예방적 또는 미연의 방지적 이득을 제공하는 약제학적 제제의 양을 언급한다.
"영역"은 적어도 하나의 동정가능한 구조, 기능 또는 특징을 갖는 표적 핵산 부분으로서 정의된다.
"리보뉴클레오타이드"는 뉴클레오타이드의 당 부분의 2' 위치에서 하이드록시를 갖는 뉴클레오타이드를 의미한다. 리보뉴클레오타이드는 임의의 다양한 치환체로 변형될 수 있다.
"절편"은 표적 핵산내 영역의 보다 작거나 서브-부분으로서 정의된다.
"부작용"은 목적하는 효과 이외의 치료에 기인할 수 있는 생리학적 질환 및/또는 병태를 의미한다. 특정 구현예에서, 부작용은 주사 부위 반응, 간 기능 시험 비정상, 신장 기능 비정상, 간 독성, 신장 독성, 중추신경계 비정상, 근질환 및 불쾌감을 포함한다. 예를 들어, 혈청에서 증가된 아미노트랜스퍼라제 수준은 간 독성 또는 간 기능 비정상을 지적할 수 있다. 예를 들어, 증가된 빌리루빈은 간 독성 또는 간 기능 비정상을 지적할 수 있다.
본원에 사용된 바와 같은 "부위"는 표적 핵산내 고유 뉴클레오염기 위치로서 정의된다.
"느린 진행"은 상기 질환의 발달 감소를 의미한다.
"특이적으로 하이브리드화할 수 있는"은 목적하는 효과를 유도하기 위해 안티센스 올리고뉴클레오타이드와 표적 핵산간에 충분한 정도의 상보성을 갖지만 특이적 결합이 요구되는 조건하에서, 즉, 생체내 분석 및 치료학적 치료의 경우에 생리학적 조건에서 비-표적 핵산에 최소의 효과를 나타내거나 효과를 나타내지 않는 안티센스 화합물을 언급한다. "엄중 하이브리드화 조건" 또는 "엄중 조건"은 올리고머 화합물이 이의 표적 서열에 하이브리드화하지만 최소수의 다른 서열에 하이브리드화하는 조건을 언급한다.
"대상체"는 치료 또는 치료요법을 위해 선택된 사람 또는 비-사람 동물을 의미한다.
"표적물"은 이의 조절이 요망되는 단백질을 언급한다.
"표적 유전자"는 표적을 암호화하는 유전자를 언급한다.
"표적화"는 특이적으로 표적 핵산에 하이브리드화하여 목적하는 효과를 유도하는 안티센스 화합물의 디자인 및 선별 과정을 의미한다.
"표적 핵산", "표적 RNA", "표적 RNA 전사체" 및 "핵산 표적"은 모두 안티센스 화합물에 표적화될 수 있는 핵산을 의미한다.
"표적 영역"은 하나 이상의 안티센스 화합물이 표적화된 표적 핵산 부분을 의미한다.
"표적 절편"은 안티센스 화합물이 표적화된 표적 핵산의 뉴클레오타이드의 서열을 의미한다. "5' 표적 부위"는 표적 절편의 5' 최외각 뉴클레오타이드를 언급한다. "3' 표적 부위는 표적 절편의 3' 최외각 뉴클레오타이드를 언급한다.
"치료학적 유효량"은 개체에 치료학적 이득을 제공하는 약제학적 제제의 양을 의미한다.
"치료하다"는 동물에서 질환, 장애 또는 병태의 변화 또는 개선을 수행하기 위해 동물에게 약제학적 조성물을 투여하는 것을 언급한다. 특정 구현예에서, 하나 이상의 약제학적 조성물은 동물에게 투여될 수 있다.
"비변형된" 뉴클레오염기는 퓨린 염기인 아데닌(A) 및 구아닌(G) 및 피리미딘 염기인 티민 (T), 사이토신 (C) 및 우라실 (U)을 의미한다.
"비변형된 뉴클레오타이드"는 천연에 존재하는 뉴클레오염기, 당 잔기 및 뉴클레오사이드 상호 연결체로 구성된 뉴클레오타이드를 의미한다. 특정 구현예에서, 비변형된 뉴클레오타이드는 RNA 뉴클레오타이드(즉 β-D-리보뉴클레오사이드) 또는 DNA 뉴클레오타이드 (즉, β-D-데옥시리보뉴클레오사이드)이다.
어떤 구현예
어떤 구현예는 성장 호르몬 수용체 (GHR) 발현을 억제하는 방법, 화합물 및 조성물을 제공한다.
어떤 구현예는 GHR 핵산에 대해 표적화된 안티센스 화합물을 제공한다. 어떤 구현예에서, 상기 GHR 핵산은 하기에서 제시된 서열을 갖는다: 유전자은행 수납 번호 NM_000163.4 (하기로서 편입되어 있음: 서열번호: 뉴클레오타이드 42411001-42714000으로부터 절단된 GENBANK 승인번호 NT_006576.16 (서열번호 2로서 본원에 언급됨) GENBANK 승인번호 X06562.1 (서열번호 3으로서 본원에 언급됨) GENBANK 승인번호 DR006395.1 (서열번호 4로서 본원에 언급됨) GENBANK 승인번호 DB052048.1 (서열번호 5로서 본원에 언급됨) GENBANK 승인번호 AF230800.1 (서열번호 6으로서 본원에 언급됨) GENBANK 승인번호 AA398260.1의 상보체 (서열번호 7로서 본원에 언급됨) GENBANK 승인번호 BC136496.1 (서열번호 8로서 본원에 언급됨) GENBANK 승인번호 NM_001242399.2 (서열번호 9로서 본원에 언급됨) GENBANK 승인번호 NM_001242400.2 (서열번호 10으로서 본원에 언급됨) GENBANK 승인번호 NM_001242401.3 (서열번호 11로서 본원에 언급됨) GENBANK 승인번호 NM_001242402.2 (서열번호 12로서 본원에 언급됨) GENBANK 승인번호 NM_001242403.2 (서열번호 13으로서 본원에 언급됨) GENBANK 승인번호 NM_001242404.2 (서열번호 14로서 본원에 언급됨) GENBANK 승인번호 NM_001242405.2 (서열번호 15로서 본원에 언급됨) GENBANK 승인번호 NM_001242406.2 (서열번호 16으로서 본원에 언급됨) GENBANK 승인번호 NM_001242460.1 (서열번호 17로서 본원에 언급됨) GENBANK 승인번호 NM_001242461.1 (서열번호 18로서 본원에 언급됨), 또는 유전자은행 수납 번호 NM_001242462.1 (하기로서 편입되어 있음: 서열번호: 19).
어떤 구현예는 10-30개의 연결된 뉴클레오사이드로 이루어지고 하기의 핵염기 서열 중 어느 것의 적어도 8개의 인접 핵염기를 포함하는 핵염기 서열을 갖는 변형된 올리고뉴클레오타이드를 포함하는 화합물을 제공한다: 서열번호: 20-2295.
어떤 구현예는 하기 내에서 상보적인 10-30개의 연결된 뉴클레오사이드로 이루어진 변형된 올리고뉴클레오타이드를 포함하는 화합물을 제공한다: 서열번호: 1의 뉴클레오타이드 30-51, 63-82, 103-118, 143-159, 164-197, 206-259, 361-388, 554-585, 625-700, 736-776, 862-887, 923-973, 978-996, 1127-1142, 1170-1195, 1317-1347, 1360-1383, 1418-1449, 1492-1507, 1524-1548, 1597-1634, 1641-1660, 1683-1698, 1744-1768, 1827-1860, 1949-2002, 2072-2092, 2095-2110, 2306-2321, 2665-2683, 2685-2719, 2739-2770, 2859-2880, 2941-2960, 2963-2978, 3037-3052, 3205-3252, 3306-3332, 3371-3386, 3518-3542, 3975-3990, 4041-4087, 4418-4446, 4528-4546, 7231-7246, 7570-7585, 8395-8410, 9153-9168, 9554-9569, 9931-9946, 10549-10564, 11020-11035, 11793-11808, 12214-12229, 12474-12489, 12905-12920, 13400-13415, 13717-13732, 14149-14164, 14540-14555, 15264-15279, 15849-15864, 16530-16545, 17377-17392, 17581-17596, 17943-17958, 18353-18368, 18636-18651, 19256-19271, 19814-19829, 20365-20380, 20979-20994, 21566-21581, 22150-22165, 22803-22818, 29049-29064, 29554-29569, 30245-30260, 30550-30565, 30915-30930, 31468-31483, 32366-32381, 32897-32912, 33187-33202, 33780-33795, 34407-34422, 34846-34861, 35669-35684, 36312-36327, 36812-36827, 37504-37519, 38841-38856, 40250-40265, 40706-40721, 40922-40937, 41424-41439, 41999-42014, 42481-42496, 42700-42715, 43291-43306, 43500-43515, 43947-43962, 44448-44463, 45162-45177, 46010-46025, 46476-46491, 47447-47462, 47752-47767, 48001-48016, 48423-48438, 50195-50210, 50470-50485, 51104-51119, 51756-51771, 52015-52030, 52230-52245, 52588-52603, 53532-53547, 또는 54645-54660, 상기 변형된 올리고뉴클레오타이드는 서열번호: 1에 대해 적어도 90% 상보적이다.
어떤 구현예는 하기의 동등 길이부에 대해 100% 상보적인 적어도 8개의 인접 핵염기의 부분을 포함하는 핵염기 서열을 갖는 10-30개의 연결된 뉴클레오사이드로 이루어진 변형된 올리고뉴클레오타이드를 포함하는 화합물을 제공한다: 서열번호 1의 핵염기 30-51, 63-82, 103-118, 143-159, 164-197, 206-259, 361-388, 554-585, 625-700, 736-776, 862-887, 923-973, 978-996, 1127-1142, 1170-1195, 1317-1347, 1360-1383, 1418-1449, 1492-1507, 1524-1548, 1597-1634, 1641-1660, 1683-1698, 1744-1768, 1827-1860, 1949-2002, 2072-2092, 2095-2110, 2306-2321, 2665-2683, 2685-2719, 2739-2770, 2859-2880, 2941-2960, 2963-2978, 3037-3052, 3205-3252, 3306-3332, 3371-3386, 3518-3542, 3975-3990, 4041-4087, 4418-4446, 4528-4546, 7231-7246, 7570-7585, 8395-8410, 9153-9168, 9554-9569, 9931-9946, 10549-10564, 11020-11035, 11793-11808, 12214-12229, 12474-12489, 12905-12920, 13400-13415, 13717-13732, 14149-14164, 14540-14555, 15264-15279, 15849-15864, 16530-16545, 17377-17392, 17581-17596, 17943-17958, 18353-18368, 18636-18651, 19256-19271, 19814-19829, 20365-20380, 20979-20994, 21566-21581, 22150-22165, 22803-22818, 29049-29064, 29554-29569, 30245-30260, 30550-30565, 30915-30930, 31468-31483, 32366-32381, 32897-32912, 33187-33202, 33780-33795, 34407-34422, 34846-34861, 35669-35684, 36312-36327, 36812-36827, 37504-37519, 38841-38856, 40250-40265, 40706-40721, 40922-40937, 41424-41439, 41999-42014, 42481-42496, 42700-42715, 43291-43306, 43500-43515, 43947-43962, 44448-44463, 45162-45177, 46010-46025, 46476-46491, 47447-47462, 47752-47767, 48001-48016, 48423-48438, 50195-50210, 50470-50485, 51104-51119, 51756-51771, 52015-52030, 52230-52245, 52588-52603, 53532-53547, 또는 54645-54660 상기 변형된 올리고뉴클레오타이드의 핵염기 서열은 서열번호: 1에 대해 상보적이다.
어떤 구현예는 하기 내에서 상보적인 10-30개의 연결된 뉴클레오사이드로 이루어진 변형된 올리고뉴클레오타이드를 포함하는 화합물을 제공한다: 서열번호: 2의 뉴클레오타이드 2571-2586, 2867-3059, 3097-3116, 3341-3695, 4024-4039, 4446-4894, 5392-5817, 6128-6265, 6499-6890, 7231-7246, 8395-8410, 9153-9168, 9554-9569, 9931-9946, 10549-10564, 10660-10679, 11020-11035, 11793-12229, 12469-12920, 13351-13415, 13717-13732, 14149-14164, 14361-14555, 14965-15279, 15849-16001, 16253-16272, 16447-16545, 17130-17149, 17377-17669, 17927-17958, 18353-18368, 18636-18773, 19661-19918, 20288-20470, 20979-20994, 21215-21606, 21820-21837, 22150-22165, 22518-22536, 22803-22818, 26494-26522, 29049-29069, 29323-29489, 30550-30565, 30915-31191, 31468-31483, 32363-32382, 32827-33202, 33635-33795, 34138-34157, 34407-34422, 34845-34864, 35466-35485, 35669-35684, 36023-36042, 36266-36327, 36721-36827, 37032-37130, 37276-37295, 37504-37675, 38094-38118, 38841-38856, 39716-40538, 40706-40937, 41164-41183, 41342-41439, 42141-42164, 42700-42760, 43173-43537, 43765-46025, 46476-46532, 48423-48438, 50072-50210, 50470-50485, 50719-51234, 51747-51797, 52015-52143, 52230-52245, 52573-52652, 53466-54660, 54886-54901, 63751-64662, 64882-65099, 65363-65378, 65600-65615, 65988-66183, 66566-66581, 66978-67080, 67251-67270, 67662-67929, 68727-68742, 69203-69242, 69565-69620, 69889-70145, 70352-70584, 70925-71071, 71314-71329, 71617-71769, 72107-72241, 72584-72670, 73061-73076, 73350-73369, 73689-73723, 74107-74131, 74317-74557, 74947-75009, 75192-75207, 75979-76066, 76410-77095, 77292-77307, 77638-77869, 78122-78326, 79006-79021, 79478-79505, 80277-80292, 80575-80939, 81207-81222, 81524-81543, 81761-81776, 82233-82248, 82738-83198, 83330-83416, 83884-84063, 84381-85964, 86220-86392, 86554-86655, 86901-86920, 87181-87262, 88063-88082, 88293-88308, 88605-88967, 89160-89175, 89940-90255, 90473-90528, 91073-91088, 91273-91292, 91647-91662, 91930-92126, 92356-92371, 93190-93443, 93762-94111, 94374-94389, 94581-94653, 94839-94858, 95292-95583, 95829-95844, 96137-96503, 96793-97013, 97539-97554, 97800-97889, 98132-98151, 98624-98672, 98810-99115, 99258-99273, 99478-99503, 99791-99858, 100281-100300, 100406-100421, 100742-100828, 101080-101103, 101242-101320, 101788-101906, 102549-102568, 103566-103625, 104067-104086, 104277-104858, 105255-105274, 106147-106364, 106632-106647, 106964-107735, 108514-108788, 109336-109505, 109849-109864, 110403-110442, 110701-110974, 111203-111322, 112030-112049, 112499-112514, 112842-112861, 113028-113056, 113646-113665, 113896-113911, 114446-114465, 115087-115106, 119269-119284, 119659-119703, 120376-120497, 120738-120845, 121209-121228, 121823-122013, 122180-122199, 122588-122770, 123031-123050, 123152-123167, 123671-124055, 124413-124608, 125178-125197, 125533-125616, 126357-126434, 126736-126751, 126998-127236, 127454-127682, 128467-128482, 128813-129111, 129976-130013, 130308-130323, 131036-131056, 131286-131305, 131676-131691, 132171-132517, 133168-133241, 133522-133877, 134086-134101, 134240-134259, 134441-134617, 135015-135030, 135431-135519, 135818-135874, 136111-136130, 136282-136595, 136996-137152, 137372-137387, 137750-137765, 138048-138067, 138782-139840, 140343-140358, 140593-140701, 141116-141131, 141591-141719, 142113-142342, 143021-143048, 143185-143486, 143836-144109, 144558-144650, 144990-145078, 145428-145525, 145937-145952, 146235-146386, 147028-147043, 147259-147284, 147671-147686, 148059-148154, 148564-148579, 148904-149084, 149491-149506, 149787-149877, 150236-150251, 150588-151139, 151373-151659, 152201-152388, 152549-152771, 153001-153026, 153349-153364, 153831-154112, 154171-154186, 154502-154521, 154724-154828, 155283-155304, 155591-155616, 155889-155992, 156233-156612, 156847-156907, 157198-157223, 157330-157349, 157552-157567, 157927-158029, 158542-158631, 159216-159267, 159539-159793, 160352-160429, 160812-160827, 161248-161267, 161461-161607, 161821-161969, 162064-162083, 162132-162147, 162531-162770, 163019-163557, 164839-165059, 165419-165575, 165856-165875, 166241-166450, 166837-166852, 167107-167122, 168004-168019, 168760-168823, 169062-169092, 169134-169153, 169601-169711, 170081-170291, 170407-170426, 170703-170814, 171021-171036, 171207-171226, 171431-171568, 171926-171945, 172447-172462, 172733-172956, 173045-173756, 174122-174885, 175014-177830, 178895-180539, 181514-187644, 187857-189904, 190109-194159, 194425-195723, 196536-196873, 197326-197961, 198145-198170, 198307-198381, 198715-199007, 199506-199563, 199816-199838, 200249-200635, 201258-201861, 202079-202094, 202382-202717, 203098-203934, 204181-204740, 205549-205915, 206412-206764, 207510-207532, 209999-210014, 210189-210296, 210502-210583, 210920-211418, 211836-212223, 212606-212816, 213025-213044, 213425-213440, 213825-213933, 214479-214498, 214622-214647, 214884-214951, 215446-215508, 215932-215951, 216192-217595, 218132-218248, 218526-218541, 218734-21219037, 219342-219633, 219886-220705, 221044-221059, 221483-221607, 221947-221962, 222569-222584, 222914-222998, 223436-223451, 223948-224122, 224409-224430, 224717-224769, 225133-225148, 225436-225761, 226785-226898, 227025-227040, 227218-227251, 227485-227500, 227914-228837, 229174-229189, 229423-229438, 229615-229640, 230042-230057, 230313-230595, 231218-231345, 231817-232037, 232088-232408, 232823-232848, 232884-232899, 233210-233225, 233623-233646, 234447-234466, 234876-234918, 235258-235328, 235770-235785, 236071-236213, 236684-237196, 237585-237698, 237949-237557, 244873-244897, 245319-245334, 245701-245780, 246152-246523, 246936-247031, 247203-247240, 247431-247450, 247644-247659, 248223-248363, 248694-248762, 249494-249509, 250001-250020, 250693-250708, 251214-251233, 251601-251637, 251950-252060, 252665-252680, 252838-252863, 253140-253166, 253594-253819, 254036-254083, 254246-254345, 254641-254660, 254905-254920, 255397-255422, 255618-255633, 255992-256704, 257018-257092, 257317-257332, 257818-259305, 259500-259515, 261294-261656, 262021-262036, 262453-262779, 263338-266518, 266861-267131, 267375-268051, 268366-269447, 270038-271850, 271950-271969, 272631-274145, 274205-275747, 275808-276636, 276932-277064, 277391-278380, 278932-279063, 279303-281001, 281587-281610, 282229-283668, 290035-290474, 290924-292550, 292860-294408, 295475-297012, 297587-298115, 298161-298418, 298489-298738, 299082-299187, 299276-299669, 299723-299749, 299788-300504, 또는 300835-301295 상기 변형된 올리고뉴클레오타이드는 서열번호: 2에 대해 적어도 90% 상보적이다.
어떤 구현예는 하기의 동등 길이부에 대해 100% 상보적인 적어도 8개의 인접 핵염기의 부분을 포함하는 핵염기 서열을 갖는 10-30개의 연결된 뉴클레오사이드로 이루어진 변형된 올리고뉴클레오타이드를 포함하는 화합물을 제공한다: 서열번호: 2의 핵염기 2571-2586, 2867-3059, 3097-3116, 3341-3695, 4024-4039, 4446-4894, 5392-5817, 6128-6265, 6499-6890, 7231-7246, 8395-8410, 9153-9168, 9554-9569, 9931-9946, 10549-10564, 10660-10679, 11020-11035, 11793-12229, 12469-12920, 13351-13415, 13717-13732, 14149-14164, 14361-14555, 14965-15279, 15849-16001, 16253-16272, 16447-16545, 17130-17149, 17377-17669, 17927-17958, 18353-18368, 18636-18773, 19661-19918, 20288-20470, 20979-20994, 21215-21606, 21820-21837, 22150-22165, 22518-22536, 22803-22818, 26494-26522, 29049-29069, 29323-29489, 30550-30565, 30915-31191, 31468-31483, 32363-32382, 32827-33202, 33635-33795, 34138-34157, 34407-34422, 34845-34864, 35466-35485, 35669-35684, 36023-36042, 36266-36327, 36721-36827, 37032-37130, 37276-37295, 37504-37675, 38094-38118, 38841-38856, 39716-40538, 40706-40937, 41164-41183, 41342-41439, 42141-42164, 42700-42760, 43173-43537, 43765-46025, 46476-46532, 48423-48438, 50072-50210, 50470-50485, 50719-51234, 51747-51797, 52015-52143, 52230-52245, 52573-52652, 53466-54660, 54886-54901, 63751-64662, 64882-65099, 65363-65378, 65600-65615, 65988-66183, 66566-66581, 66978-67080, 67251-67270, 67662-67929, 68727-68742, 69203-69242, 69565-69620, 69889-70145, 70352-70584, 70925-71071, 71314-71329, 71617-71769, 72107-72241, 72584-72670, 73061-73076, 73350-73369, 73689-73723, 74107-74131, 74317-74557, 74947-75009, 75192-75207, 75979-76066, 76410-77095, 77292-77307, 77638-77869, 78122-78326, 79006-79021, 79478-79505, 80277-80292, 80575-80939, 81207-81222, 81524-81543, 81761-81776, 82233-82248, 82738-83198, 83330-83416, 83884-84063, 84381-85964, 86220-86392, 86554-86655, 86901-86920, 87181-87262, 88063-88082, 88293-88308, 88605-88967, 89160-89175, 89940-90255, 90473-90528, 91073-91088, 91273-91292, 91647-91662, 91930-92126, 92356-92371, 93190-93443, 93762-94111, 94374-94389, 94581-94653, 94839-94858, 95292-95583, 95829-95844, 96137-96503, 96793-97013, 97539-97554, 97800-97889, 98132-98151, 98624-98672, 98810-99115, 99258-99273, 99478-99503, 99791-99858, 100281-100300, 100406-100421, 100742-100828, 101080-101103, 101242-101320, 101788-101906, 102549-102568, 103566-103625, 104067-104086, 104277-104858, 105255-105274, 106147-106364, 106632-106647, 106964-107735, 108514-108788, 109336-109505, 109849-109864, 110403-110442, 110701-110974, 111203-111322, 112030-112049, 112499-112514, 112842-112861, 113028-113056, 113646-113665, 113896-113911, 114446-114465, 115087-115106, 119269-119284, 119659-119703, 120376-120497, 120738-120845, 121209-121228, 121823-122013, 122180-122199, 122588-122770, 123031-123050, 123152-123167, 123671-124055, 124413-124608, 125178-125197, 125533-125616, 126357-126434, 126736-126751, 126998-127236, 127454-127682, 128467-128482, 128813-129111, 129976-130013, 130308-130323, 131036-131056, 131286-131305, 131676-131691, 132171-132517, 133168-133241, 133522-133877, 134086-134101, 134240-134259, 134441-134617, 135015-135030, 135431-135519, 135818-135874, 136111-136130, 136282-136595, 136996-137152, 137372-137387, 137750-137765, 138048-138067, 138782-139840, 140343-140358, 140593-140701, 141116-141131, 141591-141719, 142113-142342, 143021-143048, 143185-143486, 143836-144109, 144558-144650, 144990-145078, 145428-145525, 145937-145952, 146235-146386, 147028-147043, 147259-147284, 147671-147686, 148059-148154, 148564-148579, 148904-149084, 149491-149506, 149787-149877, 150236-150251, 150588-151139, 151373-151659, 152201-152388, 152549-152771, 153001-153026, 153349-153364, 153831-154112, 154171-154186, 154502-154521, 154724-154828, 155283-155304, 155591-155616, 155889-155992, 156233-156612, 156847-156907, 157198-157223, 157330-157349, 157552-157567, 157927-158029, 158542-158631, 159216-159267, 159539-159793, 160352-160429, 160812-160827, 161248-161267, 161461-161607, 161821-161969, 162064-162083, 162132-162147, 162531-162770, 163019-163557, 164839-165059, 165419-165575, 165856-165875, 166241-166450, 166837-166852, 167107-167122, 168004-168019, 168760-168823, 169062-169092, 169134-169153, 169601-169711, 170081-170291, 170407-170426, 170703-170814, 171021-171036, 171207-171226, 171431-171568, 171926-171945, 172447-172462, 172733-172956, 173045-173756, 174122-174885, 175014-177830, 178895-180539, 181514-187644, 187857-189904, 190109-194159, 194425-195723, 196536-196873, 197326-197961, 198145-198170, 198307-198381, 198715-199007, 199506-199563, 199816-199838, 200249-200635, 201258-201861, 202079-202094, 202382-202717, 203098-203934, 204181-204740, 205549-205915, 206412-206764, 207510-207532, 209999-210014, 210189-210296, 210502-210583, 210920-211418, 211836-212223, 212606-212816, 213025-213044, 213425-213440, 213825-213933, 214479-214498, 214622-214647, 214884-214951, 215446-215508, 215932-215951, 216192-217595, 218132-218248, 218526-218541, 218734-21219037, 219342-219633, 219886-220705, 221044-221059, 221483-221607, 221947-221962, 222569-222584, 222914-222998, 223436-223451, 223948-224122, 224409-224430, 224717-224769, 225133-225148, 225436-225761, 226785-226898, 227025-227040, 227218-227251, 227485-227500, 227914-228837, 229174-229189, 229423-229438, 229615-229640, 230042-230057, 230313-230595, 231218-231345, 231817-232037, 232088-232408, 232823-232848, 232884-232899, 233210-233225, 233623-233646, 234447-234466, 234876-234918, 235258-235328, 235770-235785, 236071-236213, 236684-237196, 237585-237698, 237949-237557, 244873-244897, 245319-245334, 245701-245780, 246152-246523, 246936-247031, 247203-247240, 247431-247450, 247644-247659, 248223-248363, 248694-248762, 249494-249509, 250001-250020, 250693-250708, 251214-251233, 251601-251637, 251950-252060, 252665-252680, 252838-252863, 253140-253166, 253594-253819, 254036-254083, 254246-254345, 254641-254660, 254905-254920, 255397-255422, 255618-255633, 255992-256704, 257018-257092, 257317-257332, 257818-259305, 259500-259515, 261294-261656, 262021-262036, 262453-262779, 263338-266518, 266861-267131, 267375-268051, 268366-269447, 270038-271850, 271950-271969, 272631-274145, 274205-275747, 275808-276636, 276932-277064, 277391-278380, 278932-279063, 279303-281001, 281587-281610, 282229-283668, 290035-290474, 290924-292550, 292860-294408, 295475-297012, 297587-298115, 298161-298418, 298489-298738, 299082-299187, 299276-299669, 299723-299749, 299788-300504, 또는 300835-301295 상기 변형된 올리고뉴클레오타이드의 핵염기 서열은 서열번호: 2에 대해 상보적이다. 어떤 측면에서, 본 화합물은 하기 내에서 상보적인 10-30개의 연결된 뉴클레오사이드로 이루어진 변형된 올리고뉴클레오타이드를 포함한다: 서열번호: 2의 뉴클레오타이드 155594-155613, 72107-72126, 153921-153940, 159252-159267, 213425-213440, 153004-153019, 155597-155612, 248233-248248.
어떤 구현예는 10-30개의 연결된 뉴클레오사이드로 이루어지고 하기 중 어느 하나의 핵염기 서열을 포함하는 핵염기 서열을 갖는 변형된 올리고뉴클레오타이드를 포함하는 화합물을 제공한다: 서열번호: 20-2295.
어떤 구현예는 하기 중 어느 하나의 핵염기 서열로 이루어진 변형된 올리고뉴클레오타이드를 포함하는 화합물을 제공한다: 서열번호: 20-2295.
어떤 구현예에서, 성장 호르몬 수용체 핵산에 대해 표적화된 안티센스 화합물 또는 올리고뉴클레오타이드는 하기의 뉴클레오타이드 영역 내에서 상보적이다: 서열번호: 1: 30-51, 63-82, 103-118, 143-159, 164-197, 206-259, 361-388, 554-585, 625-700, 736-776, 862-887, 923-973, 978-996, 1127-1142, 1170-1195, 1317-1347, 1360-1383, 1418-1449, 1492-1507, 1524-1548, 1597-1634, 1641-1660, 1683-1698, 1744-1768, 1827-1860, 1949-2002, 2072-2092, 2095-2110, 2306-2321, 2665-2683, 2685-2719, 2739-2770, 2859-2880, 2941-2960, 2963-2978, 3037-3052, 3205-3252, 3306-3332, 3371-3386, 3518-3542, 3975-3990, 4041-4087, 4418-4446, 4528-4546, 7231-7246, 7570-7585, 8395-8410, 9153-9168, 9554-9569, 9931-9946, 10549-10564, 11020-11035, 11793-11808, 12214-12229, 12474-12489, 12905-12920, 13400-13415, 13717-13732, 14149-14164, 14540-14555, 15264-15279, 15849-15864, 16530-16545, 17377-17392, 17581-17596, 17943-17958, 18353-18368, 18636-18651, 19256-19271, 19814-19829, 20365-20380, 20979-20994, 21566-21581, 22150-22165, 22803-22818, 29049-29064, 29554-29569, 30245-30260, 30550-30565, 30915-30930, 31468-31483, 32366-32381, 32897-32912, 33187-33202, 33780-33795, 34407-34422, 34846-34861, 35669-35684, 36312-36327, 36812-36827, 37504-37519, 38841-38856, 40250-40265, 40706-40721, 40922-40937, 41424-41439, 41999-42014, 42481-42496, 42700-42715, 43291-43306, 43500-43515, 43947-43962, 44448-44463, 45162-45177, 46010-46025, 46476-46491, 47447-47462, 47752-47767, 48001-48016, 48423-48438, 50195-50210, 50470-50485, 51104-51119, 51756-51771, 52015-52030, 52230-52245, 52588-52603, 53532-53547, 또는 54645-54660.
어떤 구현예에서, 성장 호르몬 수용체 핵산에 대해 표적화된 안티센스 화합물 또는 올리고뉴클레오타이드는 하기의 뉴클레오타이드 영역을 표적으로 한다: 서열번호: 1: 30-51, 63-82, 103-118, 143-159, 164-197, 206-259, 361-388, 554-585, 625-700, 736-776, 862-887, 923-973, 978-996, 1127-1142, 1170-1195, 1317-1347, 1360-1383, 1418-1449, 1492-1507, 1524-1548, 1597-1634, 1641-1660, 1683-1698, 1744-1768, 1827-1860, 1949-2002, 2072-2092, 2095-2110, 2306-2321, 2665-2683, 2685-2719, 2739-2770, 2859-2880, 2941-2960, 2963-2978, 3037-3052, 3205-3252, 3306-3332, 3371-3386, 3518-3542, 3975-3990, 4041-4087, 4418-4446, 4528-4546, 7231-7246, 7570-7585, 8395-8410, 9153-9168, 9554-9569, 9931-9946, 10549-10564, 11020-11035, 11793-11808, 12214-12229, 12474-12489, 12905-12920, 13400-13415, 13717-13732, 14149-14164, 14540-14555, 15264-15279, 15849-15864, 16530-16545, 17377-17392, 17581-17596, 17943-17958, 18353-18368, 18636-18651, 19256-19271, 19814-19829, 20365-20380, 20979-20994, 21566-21581, 22150-22165, 22803-22818, 29049-29064, 29554-29569, 30245-30260, 30550-30565, 30915-30930, 31468-31483, 32366-32381, 32897-32912, 33187-33202, 33780-33795, 34407-34422, 34846-34861, 35669-35684, 36312-36327, 36812-36827, 37504-37519, 38841-38856, 40250-40265, 40706-40721, 40922-40937, 41424-41439, 41999-42014, 42481-42496, 42700-42715, 43291-43306, 43500-43515, 43947-43962, 44448-44463, 45162-45177, 46010-46025, 46476-46491, 47447-47462, 47752-47767, 48001-48016, 48423-48438, 50195-50210, 50470-50485, 51104-51119, 51756-51771, 52015-52030, 52230-52245, 52588-52603, 53532-53547, 또는 54645-54660.
어떤 구현예에서, 안티센스 화합물 또는 올리고뉴클레오타이드는 성장 호르몬 수용체 핵산의 영역을 표적으로 한다. 어떤 구현예에서, GHR 핵산의 영역에 대해 표적화된 그와 같은 화합물 또는 올리고뉴클레오타이드는 영역의 동등 길이 핵염기부에 대해 상보적인 인접 핵염기부를 갖는다. 예를 들면, 상기 부분은 본원에서 인용된 영역의 동등 길이부에 대해 상보적인 적어도 8, 9, 10, 11, 12, 13, 14, 15, 또는 16개의 인접 핵염기부일 수 있다. 어떤 구현예에서, 그와 같은 화합물 또는 올리고뉴클레오타이드는 하기의 뉴클레오타이드 영역을 표적으로 한다: 서열번호: 1: 30-51, 63-82, 103-118, 143-159, 164-197, 206-259, 361-388, 554-585, 625-700, 736-776, 862-887, 923-973, 978-996, 1127-1142, 1170-1195, 1317-1347, 1360-1383, 1418-1449, 1492-1507, 1524-1548, 1597-1634, 1641-1660, 1683-1698, 1744-1768, 1827-1860, 1949-2002, 2072-2092, 2095-2110, 2306-2321, 2665-2683, 2685-2719, 2739-2770, 2859-2880, 2941-2960, 2963-2978, 3037-3052, 3205-3252, 3306-3332, 3371-3386, 3518-3542, 3975-3990, 4041-4087, 4418-4446, 4528-4546, 7231-7246, 7570-7585, 8395-8410, 9153-9168, 9554-9569, 9931-9946, 10549-10564, 11020-11035, 11793-11808, 12214-12229, 12474-12489, 12905-12920, 13400-13415, 13717-13732, 14149-14164, 14540-14555, 15264-15279, 15849-15864, 16530-16545, 17377-17392, 17581-17596, 17943-17958, 18353-18368, 18636-18651, 19256-19271, 19814-19829, 20365-20380, 20979-20994, 21566-21581, 22150-22165, 22803-22818, 29049-29064, 29554-29569, 30245-30260, 30550-30565, 30915-30930, 31468-31483, 32366-32381, 32897-32912, 33187-33202, 33780-33795, 34407-34422, 34846-34861, 35669-35684, 36312-36327, 36812-36827, 37504-37519, 38841-38856, 40250-40265, 40706-40721, 40922-40937, 41424-41439, 41999-42014, 42481-42496, 42700-42715, 43291-43306, 43500-43515, 43947-43962, 44448-44463, 45162-45177, 46010-46025, 46476-46491, 47447-47462, 47752-47767, 48001-48016, 48423-48438, 50195-50210, 50470-50485, 51104-51119, 51756-51771, 52015-52030, 52230-52245, 52588-52603, 53532-53547, 또는 54645-54660.
어떤 구현예에서, 성장 호르몬 수용체 핵산에 대해 표적화된 안티센스 화합물 또는 올리고뉴클레오타이드는 하기의 뉴클레오타이드 영역 내에서 상보적이다: 서열번호: 2: 2571-2586, 2867-3059, 3097-3116, 3341-3695, 4024-4039, 4446-4894, 5392-5817, 6128-6265, 6499-6890, 7231-7246, 8395-8410, 9153-9168, 9554-9569, 9931-9946, 10549-10564, 10660-10679, 11020-11035, 11793-12229, 12469-12920, 13351-13415, 13717-13732, 14149-14164, 14361-14555, 14965-15279, 15849-16001, 16253-16272, 16447-16545, 17130-17149, 17377-17669, 17927-17958, 18353-18368, 18636-18773, 19661-19918, 20288-20470, 20979-20994, 21215-21606, 21820-21837, 22150-22165, 22518-22536, 22803-22818, 26494-26522, 29049-29069, 29323-29489, 30550-30565, 30915-31191, 31468-31483, 32363-32382, 32827-33202, 33635-33795, 34138-34157, 34407-34422, 34845-34864, 35466-35485, 35669-35684, 36023-36042, 36266-36327, 36721-36827, 37032-37130, 37276-37295, 37504-37675, 38094-38118, 38841-38856, 39716-40538, 40706-40937, 41164-41183, 41342-41439, 42141-42164, 42700-42760, 43173-43537, 43765-46025, 46476-46532, 48423-48438, 50072-50210, 50470-50485, 50719-51234, 51747-51797, 52015-52143, 52230-52245, 52573-52652, 53466-54660, 54886-54901, 63751-64662, 64882-65099, 65363-65378, 65600-65615, 65988-66183, 66566-66581, 66978-67080, 67251-67270, 67662-67929, 68727-68742, 69203-69242, 69565-69620, 69889-70145, 70352-70584, 70925-71071, 71314-71329, 71617-71769, 72107-72241, 72584-72670, 73061-73076, 73350-73369, 73689-73723, 74107-74131, 74317-74557, 74947-75009, 75192-75207, 75979-76066, 76410-77095, 77292-77307, 77638-77869, 78122-78326, 79006-79021, 79478-79505, 80277-80292, 80575-80939, 81207-81222, 81524-81543, 81761-81776, 82233-82248, 82738-83198, 83330-83416, 83884-84063, 84381-85964, 86220-86392, 86554-86655, 86901-86920, 87181-87262, 88063-88082, 88293-88308, 88605-88967, 89160-89175, 89940-90255, 90473-90528, 91073-91088, 91273-91292, 91647-91662, 91930-92126, 92356-92371, 93190-93443, 93762-94111, 94374-94389, 94581-94653, 94839-94858, 95292-95583, 95829-95844, 96137-96503, 96793-97013, 97539-97554, 97800-97889, 98132-98151, 98624-98672, 98810-99115, 99258-99273, 99478-99503, 99791-99858, 100281-100300, 100406-100421, 100742-100828, 101080-101103, 101242-101320, 101788-101906, 102549-102568, 103566-103625, 104067-104086, 104277-104858, 105255-105274, 106147-106364, 106632-106647, 106964-107735, 108514-108788, 109336-109505, 109849-109864, 110403-110442, 110701-110974, 111203-111322, 112030-112049, 112499-112514, 112842-112861, 113028-113056, 113646-113665, 113896-113911, 114446-114465, 115087-115106, 119269-119284, 119659-119703, 120376-120497, 120738-120845, 121209-121228, 121823-122013, 122180-122199, 122588-122770, 123031-123050, 123152-123167, 123671-124055, 124413-124608, 125178-125197, 125533-125616, 126357-126434, 126736-126751, 126998-127236, 127454-127682, 128467-128482, 128813-129111, 129976-130013, 130308-130323, 131036-131056, 131286-131305, 131676-131691, 132171-132517, 133168-133241, 133522-133877, 134086-134101, 134240-134259, 134441-134617, 135015-135030, 135431-135519, 135818-135874, 136111-136130, 136282-136595, 136996-137152, 137372-137387, 137750-137765, 138048-138067, 138782-139840, 140343-140358, 140593-140701, 141116-141131, 141591-141719, 142113-142342, 143021-143048, 143185-143486, 143836-144109, 144558-144650, 144990-145078, 145428-145525, 145937-145952, 146235-146386, 147028-147043, 147259-147284, 147671-147686, 148059-148154, 148564-148579, 148904-149084, 149491-149506, 149787-149877, 150236-150251, 150588-151139, 151373-151659, 152201-152388, 152549-152771, 153001-153026, 153349-153364, 153831-154112, 154171-154186, 154502-154521, 154724-154828, 155283-155304, 155591-155616, 155889-155992, 156233-156612, 156847-156907, 157198-157223, 157330-157349, 157552-157567, 157927-158029, 158542-158631, 159216-159267, 159539-159793, 160352-160429, 160812-160827, 161248-161267, 161461-161607, 161821-161969, 162064-162083, 162132-162147, 162531-162770, 163019-163557, 164839-165059, 165419-165575, 165856-165875, 166241-166450, 166837-166852, 167107-167122, 168004-168019, 168760-168823, 169062-169092, 169134-169153, 169601-169711, 170081-170291, 170407-170426, 170703-170814, 171021-171036, 171207-171226, 171431-171568, 171926-171945, 172447-172462, 172733-172956, 173045-173756, 174122-174885, 175014-177830, 178895-180539, 181514-187644, 187857-189904, 190109-194159, 194425-195723, 196536-196873, 197326-197961, 198145-198170, 198307-198381, 198715-199007, 199506-199563, 199816-199838, 200249-200635, 201258-201861, 202079-202094, 202382-202717, 203098-203934, 204181-204740, 205549-205915, 206412-206764, 207510-207532, 209999-210014, 210189-210296, 210502-210583, 210920-211418, 211836-212223, 212606-212816, 213025-213044, 213425-213440, 213825-213933, 214479-214498, 214622-214647, 214884-214951, 215446-215508, 215932-215951, 216192-217595, 218132-218248, 218526-218541, 218734-21219037, 219342-219633, 219886-220705, 221044-221059, 221483-221607, 221947-221962, 222569-222584, 222914-222998, 223436-223451, 223948-224122, 224409-224430, 224717-224769, 225133-225148, 225436-225761, 226785-226898, 227025-227040, 227218-227251, 227485-227500, 227914-228837, 229174-229189, 229423-229438, 229615-229640, 230042-230057, 230313-230595, 231218-231345, 231817-232037, 232088-232408, 232823-232848, 232884-232899, 233210-233225, 233623-233646, 234447-234466, 234876-234918, 235258-235328, 235770-235785, 236071-236213, 236684-237196, 237585-237698, 237949-237557, 244873-244897, 245319-245334, 245701-245780, 246152-246523, 246936-247031, 247203-247240, 247431-247450, 247644-247659, 248223-248363, 248694-248762, 249494-249509, 250001-250020, 250693-250708, 251214-251233, 251601-251637, 251950-252060, 252665-252680, 252838-252863, 253140-253166, 253594-253819, 254036-254083, 254246-254345, 254641-254660, 254905-254920, 255397-255422, 255618-255633, 255992-256704, 257018-257092, 257317-257332, 257818-259305, 259500-259515, 261294-261656, 262021-262036, 262453-262779, 263338-266518, 266861-267131, 267375-268051, 268366-269447, 270038-271850, 271950-271969, 272631-274145, 274205-275747, 275808-276636, 276932-277064, 277391-278380, 278932-279063, 279303-281001, 281587-281610, 282229-283668, 290035-290474, 290924-292550, 292860-294408, 295475-297012, 297587-298115, 298161-298418, 298489-298738, 299082-299187, 299276-299669, 299723-299749, 299788-300504, 또는 300835-301295.
어떤 구현예에서, 성장 호르몬 수용체 핵산에 대해 표적화된 안티센스 화합물 또는 올리고뉴클레오타이드는 하기의 뉴클레오타이드 영역을 표적으로 한다: 서열번호: 2: 2571-2586, 2867-3059, 3097-3116, 3341-3695, 4024-4039, 4446-4894, 5392-5817, 6128-6265, 6499-6890, 7231-7246, 8395-8410, 9153-9168, 9554-9569, 9931-9946, 10549-10564, 10660-10679, 11020-11035, 11793-12229, 12469-12920, 13351-13415, 13717-13732, 14149-14164, 14361-14555, 14965-15279, 15849-16001, 16253-16272, 16447-16545, 17130-17149, 17377-17669, 17927-17958, 18353-18368, 18636-18773, 19661-19918, 20288-20470, 20979-20994, 21215-21606, 21820-21837, 22150-22165, 22518-22536, 22803-22818, 26494-26522, 29049-29069, 29323-29489, 30550-30565, 30915-31191, 31468-31483, 32363-32382, 32827-33202, 33635-33795, 34138-34157, 34407-34422, 34845-34864, 35466-35485, 35669-35684, 36023-36042, 36266-36327, 36721-36827, 37032-37130, 37276-37295, 37504-37675, 38094-38118, 38841-38856, 39716-40538, 40706-40937, 41164-41183, 41342-41439, 42141-42164, 42700-42760, 43173-43537, 43765-46025, 46476-46532, 48423-48438, 50072-50210, 50470-50485, 50719-51234, 51747-51797, 52015-52143, 52230-52245, 52573-52652, 53466-54660, 54886-54901, 63751-64662, 64882-65099, 65363-65378, 65600-65615, 65988-66183, 66566-66581, 66978-67080, 67251-67270, 67662-67929, 68727-68742, 69203-69242, 69565-69620, 69889-70145, 70352-70584, 70925-71071, 71314-71329, 71617-71769, 72107-72241, 72584-72670, 73061-73076, 73350-73369, 73689-73723, 74107-74131, 74317-74557, 74947-75009, 75192-75207, 75979-76066, 76410-77095, 77292-77307, 77638-77869, 78122-78326, 79006-79021, 79478-79505, 80277-80292, 80575-80939, 81207-81222, 81524-81543, 81761-81776, 82233-82248, 82738-83198, 83330-83416, 83884-84063, 84381-85964, 86220-86392, 86554-86655, 86901-86920, 87181-87262, 88063-88082, 88293-88308, 88605-88967, 89160-89175, 89940-90255, 90473-90528, 91073-91088, 91273-91292, 91647-91662, 91930-92126, 92356-92371, 93190-93443, 93762-94111, 94374-94389, 94581-94653, 94839-94858, 95292-95583, 95829-95844, 96137-96503, 96793-97013, 97539-97554, 97800-97889, 98132-98151, 98624-98672, 98810-99115, 99258-99273, 99478-99503, 99791-99858, 100281-100300, 100406-100421, 100742-100828, 101080-101103, 101242-101320, 101788-101906, 102549-102568, 103566-103625, 104067-104086, 104277-104858, 105255-105274, 106147-106364, 106632-106647, 106964-107735, 108514-108788, 109336-109505, 109849-109864, 110403-110442, 110701-110974, 111203-111322, 112030-112049, 112499-112514, 112842-112861, 113028-113056, 113646-113665, 113896-113911, 114446-114465, 115087-115106, 119269-119284, 119659-119703, 120376-120497, 120738-120845, 121209-121228, 121823-122013, 122180-122199, 122588-122770, 123031-123050, 123152-123167, 123671-124055, 124413-124608, 125178-125197, 125533-125616, 126357-126434, 126736-126751, 126998-127236, 127454-127682, 128467-128482, 128813-129111, 129976-130013, 130308-130323, 131036-131056, 131286-131305, 131676-131691, 132171-132517, 133168-133241, 133522-133877, 134086-134101, 134240-134259, 134441-134617, 135015-135030, 135431-135519, 135818-135874, 136111-136130, 136282-136595, 136996-137152, 137372-137387, 137750-137765, 138048-138067, 138782-139840, 140343-140358, 140593-140701, 141116-141131, 141591-141719, 142113-142342, 143021-143048, 143185-143486, 143836-144109, 144558-144650, 144990-145078, 145428-145525, 145937-145952, 146235-146386, 147028-147043, 147259-147284, 147671-147686, 148059-148154, 148564-148579, 148904-149084, 149491-149506, 149787-149877, 150236-150251, 150588-151139, 151373-151659, 152201-152388, 152549-152771, 153001-153026, 153349-153364, 153831-154112, 154171-154186, 154502-154521, 154724-154828, 155283-155304, 155591-155616, 155889-155992, 156233-156612, 156847-156907, 157198-157223, 157330-157349, 157552-157567, 157927-158029, 158542-158631, 159216-159267, 159539-159793, 160352-160429, 160812-160827, 161248-161267, 161461-161607, 161821-161969, 162064-162083, 162132-162147, 162531-162770, 163019-163557, 164839-165059, 165419-165575, 165856-165875, 166241-166450, 166837-166852, 167107-167122, 168004-168019, 168760-168823, 169062-169092, 169134-169153, 169601-169711, 170081-170291, 170407-170426, 170703-170814, 171021-171036, 171207-171226, 171431-171568, 171926-171945, 172447-172462, 172733-172956, 173045-173756, 174122-174885, 175014-177830, 178895-180539, 181514-187644, 187857-189904, 190109-194159, 194425-195723, 196536-196873, 197326-197961, 198145-198170, 198307-198381, 198715-199007, 199506-199563, 199816-199838, 200249-200635, 201258-201861, 202079-202094, 202382-202717, 203098-203934, 204181-204740, 205549-205915, 206412-206764, 207510-207532, 209999-210014, 210189-210296, 210502-210583, 210920-211418, 211836-212223, 212606-212816, 213025-213044, 213425-213440, 213825-213933, 214479-214498, 214622-214647, 214884-214951, 215446-215508, 215932-215951, 216192-217595, 218132-218248, 218526-218541, 218734-21219037, 219342-219633, 219886-220705, 221044-221059, 221483-221607, 221947-221962, 222569-222584, 222914-222998, 223436-223451, 223948-224122, 224409-224430, 224717-224769, 225133-225148, 225436-225761, 226785-226898, 227025-227040, 227218-227251, 227485-227500, 227914-228837, 229174-229189, 229423-229438, 229615-229640, 230042-230057, 230313-230595, 231218-231345, 231817-232037, 232088-232408, 232823-232848, 232884-232899, 233210-233225, 233623-233646, 234447-234466, 234876-234918, 235258-235328, 235770-235785, 236071-236213, 236684-237196, 237585-237698, 237949-237557, 244873-244897, 245319-245334, 245701-245780, 246152-246523, 246936-247031, 247203-247240, 247431-247450, 247644-247659, 248223-248363, 248694-248762, 249494-249509, 250001-250020, 250693-250708, 251214-251233, 251601-251637, 251950-252060, 252665-252680, 252838-252863, 253140-253166, 253594-253819, 254036-254083, 254246-254345, 254641-254660, 254905-254920, 255397-255422, 255618-255633, 255992-256704, 257018-257092, 257317-257332, 257818-259305, 259500-259515, 261294-261656, 262021-262036, 262453-262779, 263338-266518, 266861-267131, 267375-268051, 268366-269447, 270038-271850, 271950-271969, 272631-274145, 274205-275747, 275808-276636, 276932-277064, 277391-278380, 278932-279063, 279303-281001, 281587-281610, 282229-283668, 290035-290474, 290924-292550, 292860-294408, 295475-297012, 297587-298115, 298161-298418, 298489-298738, 299082-299187, 299276-299669, 299723-299749, 299788-300504, 또는 300835-301295.
어떤 구현예에서, 안티센스 화합물 또는 올리고뉴클레오타이드는 성장 호르몬 수용체 핵산의 영역을 표적으로 한다. 어떤 구현예에서, GHR 핵산의 영역에 대해 표적화된 그와 같은 화합물 또는 올리고뉴클레오타이드는 영역의 동등 길이 핵염기부에 대해 상보적인 인접 핵염기부를 갖는다. 예를 들면, 상기 부분은 본원에서 인용된 영역의 동등 길이부에 대해 상보적인 적어도 8, 9, 10, 11, 12, 13, 14, 15, 또는 16개의 인접 핵염기부일 수 있다. 어떤 구현예에서, 그와 같은 화합물 또는 올리고뉴클레오타이드는 하기의 뉴클레오타이드 영역을 표적으로 한다: 서열번호: 2: 2571-2586, 2867-3059, 3097-3116, 3341-3695, 4024-4039, 4446-4894, 5392-5817, 6128-6265, 6499-6890, 7231-7246, 8395-8410, 9153-9168, 9554-9569, 9931-9946, 10549-10564, 10660-10679, 11020-11035, 11793-12229, 12469-12920, 13351-13415, 13717-13732, 14149-14164, 14361-14555, 14965-15279, 15849-16001, 16253-16272, 16447-16545, 17130-17149, 17377-17669, 17927-17958, 18353-18368, 18636-18773, 19661-19918, 20288-20470, 20979-20994, 21215-21606, 21820-21837, 22150-22165, 22518-22536, 22803-22818, 26494-26522, 29049-29069, 29323-29489, 30550-30565, 30915-31191, 31468-31483, 32363-32382, 32827-33202, 33635-33795, 34138-34157, 34407-34422, 34845-34864, 35466-35485, 35669-35684, 36023-36042, 36266-36327, 36721-36827, 37032-37130, 37276-37295, 37504-37675, 38094-38118, 38841-38856, 39716-40538, 40706-40937, 41164-41183, 41342-41439, 42141-42164, 42700-42760, 43173-43537, 43765-46025, 46476-46532, 48423-48438, 50072-50210, 50470-50485, 50719-51234, 51747-51797, 52015-52143, 52230-52245, 52573-52652, 53466-54660, 54886-54901, 63751-64662, 64882-65099, 65363-65378, 65600-65615, 65988-66183, 66566-66581, 66978-67080, 67251-67270, 67662-67929, 68727-68742, 69203-69242, 69565-69620, 69889-70145, 70352-70584, 70925-71071, 71314-71329, 71617-71769, 72107-72241, 72584-72670, 73061-73076, 73350-73369, 73689-73723, 74107-74131, 74317-74557, 74947-75009, 75192-75207, 75979-76066, 76410-77095, 77292-77307, 77638-77869, 78122-78326, 79006-79021, 79478-79505, 80277-80292, 80575-80939, 81207-81222, 81524-81543, 81761-81776, 82233-82248, 82738-83198, 83330-83416, 83884-84063, 84381-85964, 86220-86392, 86554-86655, 86901-86920, 87181-87262, 88063-88082, 88293-88308, 88605-88967, 89160-89175, 89940-90255, 90473-90528, 91073-91088, 91273-91292, 91647-91662, 91930-92126, 92356-92371, 93190-93443, 93762-94111, 94374-94389, 94581-94653, 94839-94858, 95292-95583, 95829-95844, 96137-96503, 96793-97013, 97539-97554, 97800-97889, 98132-98151, 98624-98672, 98810-99115, 99258-99273, 99478-99503, 99791-99858, 100281-100300, 100406-100421, 100742-100828, 101080-101103, 101242-101320, 101788-101906, 102549-102568, 103566-103625, 104067-104086, 104277-104858, 105255-105274, 106147-106364, 106632-106647, 106964-107735, 108514-108788, 109336-109505, 109849-109864, 110403-110442, 110701-110974, 111203-111322, 112030-112049, 112499-112514, 112842-112861, 113028-113056, 113646-113665, 113896-113911, 114446-114465, 115087-115106, 119269-119284, 119659-119703, 120376-120497, 120738-120845, 121209-121228, 121823-122013, 122180-122199, 122588-122770, 123031-123050, 123152-123167, 123671-124055, 124413-124608, 125178-125197, 125533-125616, 126357-126434, 126736-126751, 126998-127236, 127454-127682, 128467-128482, 128813-129111, 129976-130013, 130308-130323, 131036-131056, 131286-131305, 131676-131691, 132171-132517, 133168-133241, 133522-133877, 134086-134101, 134240-134259, 134441-134617, 135015-135030, 135431-135519, 135818-135874, 136111-136130, 136282-136595, 136996-137152, 137372-137387, 137750-137765, 138048-138067, 138782-139840, 140343-140358, 140593-140701, 141116-141131, 141591-141719, 142113-142342, 143021-143048, 143185-143486, 143836-144109, 144558-144650, 144990-145078, 145428-145525, 145937-145952, 146235-146386, 147028-147043, 147259-147284, 147671-147686, 148059-148154, 148564-148579, 148904-149084, 149491-149506, 149787-149877, 150236-150251, 150588-151139, 151373-151659, 152201-152388, 152549-152771, 153001-153026, 153349-153364, 153831-154112, 154171-154186, 154502-154521, 154724-154828, 155283-155304, 155591-155616, 155889-155992, 156233-156612, 156847-156907, 157198-157223, 157330-157349, 157552-157567, 157927-158029, 158542-158631, 159216-159267, 159539-159793, 160352-160429, 160812-160827, 161248-161267, 161461-161607, 161821-161969, 162064-162083, 162132-162147, 162531-162770, 163019-163557, 164839-165059, 165419-165575, 165856-165875, 166241-166450, 166837-166852, 167107-167122, 168004-168019, 168760-168823, 169062-169092, 169134-169153, 169601-169711, 170081-170291, 170407-170426, 170703-170814, 171021-171036, 171207-171226, 171431-171568, 171926-171945, 172447-172462, 172733-172956, 173045-173756, 174122-174885, 175014-177830, 178895-180539, 181514-187644, 187857-189904, 190109-194159, 194425-195723, 196536-196873, 197326-197961, 198145-198170, 198307-198381, 198715-199007, 199506-199563, 199816-199838, 200249-200635, 201258-201861, 202079-202094, 202382-202717, 203098-203934, 204181-204740, 205549-205915, 206412-206764, 207510-207532, 209999-210014, 210189-210296, 210502-210583, 210920-211418, 211836-212223, 212606-212816, 213025-213044, 213425-213440, 213825-213933, 214479-214498, 214622-214647, 214884-214951, 215446-215508, 215932-215951, 216192-217595, 218132-218248, 218526-218541, 218734-21219037, 219342-219633, 219886-220705, 221044-221059, 221483-221607, 221947-221962, 222569-222584, 222914-222998, 223436-223451, 223948-224122, 224409-224430, 224717-224769, 225133-225148, 225436-225761, 226785-226898, 227025-227040, 227218-227251, 227485-227500, 227914-228837, 229174-229189, 229423-229438, 229615-229640, 230042-230057, 230313-230595, 231218-231345, 231817-232037, 232088-232408, 232823-232848, 232884-232899, 233210-233225, 233623-233646, 234447-234466, 234876-234918, 235258-235328, 235770-235785, 236071-236213, 236684-237196, 237585-237698, 237949-237557, 244873-244897, 245319-245334, 245701-245780, 246152-246523, 246936-247031, 247203-247240, 247431-247450, 247644-247659, 248223-248363, 248694-248762, 249494-249509, 250001-250020, 250693-250708, 251214-251233, 251601-251637, 251950-252060, 252665-252680, 252838-252863, 253140-253166, 253594-253819, 254036-254083, 254246-254345, 254641-254660, 254905-254920, 255397-255422, 255618-255633, 255992-256704, 257018-257092, 257317-257332, 257818-259305, 259500-259515, 261294-261656, 262021-262036, 262453-262779, 263338-266518, 266861-267131, 267375-268051, 268366-269447, 270038-271850, 271950-271969, 272631-274145, 274205-275747, 275808-276636, 276932-277064, 277391-278380, 278932-279063, 279303-281001, 281587-281610, 282229-283668, 290035-290474, 290924-292550, 292860-294408, 295475-297012, 297587-298115, 298161-298418, 298489-298738, 299082-299187, 299276-299669, 299723-299749, 299788-300504, 또는 300835-301295.
어떤 구현예에서, 안티센스 화합물 또는 올리고뉴클레오타이드는 성장 호르몬 수용체 핵산의 인트론 1을 표적으로 한다. 어떤 측면에서, 안티센스 화합물 또는 올리고뉴클레오타이드는 하기의 핵염기 서열을 갖는 성장 호르몬 수용체 핵산의 뉴클레오타이드 3058-144965 (인트론 1) 내에서 표적화된다: 서열번호: (GENBANK 승인번호 NT_006576.16, 뉴클레오타이드 42411001-42714000로부터 절단됨)로 지정된다).
어떤 구현예에서, 안티센스 화합물 또는 올리고뉴클레오타이드는 성장 호르몬 수용체 핵산의 인트론 2를 표적으로 한다. 어떤 측면에서, 안티센스 화합물 또는 올리고뉴클레오타이드는 하기의 핵염기 서열을 갖는 성장 호르몬 수용체 핵산의 뉴클레오타이드 145047-208139 (인트론 2) 내에서 표적화된다: 서열번호: 2 (GENBANK 승인번호 NT_006576.16, 뉴클레오타이드 42411001-42714000로부터 절단됨)로 지정된다).
어떤 구현예에서, 안티센스 화합물 또는 올리고뉴클레오타이드는 성장 호르몬 수용체 핵산의 인트론 3을 표적으로 한다. 어떤 측면에서, 안티센스 화합물 또는 올리고뉴클레오타이드는 하기의 핵염기 서열을 갖는 성장 호르몬 수용체 핵산의 뉴클레오타이드 208206-26779 (인트론 3) 내에서 표적화된다: 서열번호: 2 (GENBANK 승인번호 NT_006576.16, 뉴클레오타이드 42411001-42714000로부터 절단됨)로 지정된다).
어떤 구현예에서, 안티센스 화합물 또는 올리고뉴클레오타이드는 성장 호르몬 수용체 핵산의 인트론 4를 표적으로 한다. 어떤 측면에서, 안티센스 화합물 또는 올리고뉴클레오타이드는 하기의 핵염기 서열을 갖는 성장 호르몬 수용체 핵산의 뉴클레오타이드 268122-274018 (인트론 4) 내에서 표적화된다: 서열번호: 2 (GENBANK 승인번호 NT_006576.16, 뉴클레오타이드 42411001-42714000로부터 절단됨)로 지정된다).
어떤 구현예에서, 안티센스 화합물 또는 올리고뉴클레오타이드는 성장 호르몬 수용체 핵산의 인트론 5를 표적으로 한다. 어떤 측면에서, 안티센스 화합물 또는 올리고뉴클레오타이드는 하기의 핵염기 서열을 갖는 성장 호르몬 수용체 핵산의 뉴클레오타이드 274192-278925 (인트론 5) 내에서 표적화된다: 서열번호: 2 (GENBANK 승인번호 NT_006576.16, 뉴클레오타이드 42411001-42714000로부터 절단됨)로 지정된다).
어떤 구현예에서, 안티센스 화합물 또는 올리고뉴클레오타이드는 성장 호르몬 수용체 핵산의 인트론 6을 표적으로 한다. 어떤 측면에서, 안티센스 화합물 또는 올리고뉴클레오타이드는 하기의 핵염기 서열을 갖는 성장 호르몬 수용체 핵산의 뉴클레오타이드 279105-290308 (인트론 6) 내에서 표적화된다: 서열번호: 2 (GENBANK 승인번호 NT_006576.16, 뉴클레오타이드 42411001-42714000로부터 절단됨)로 지정된다).
어떤 구현예에서, 안티센스 화합물 또는 올리고뉴클레오타이드는 성장 호르몬 수용체 핵산의 인트론 7을 표적으로 한다. 어떤 측면에서, 안티센스 화합물 또는 올리고뉴클레오타이드는 하기의 핵염기 서열을 갖는 성장 호르몬 수용체 핵산의 뉴클레오타이드 290475-292530 (인트론 7) 내에서 표적화된다: 서열번호: 2 (GENBANK 승인번호 NT_006576.16, 뉴클레오타이드 42411001-42714000로부터 절단됨)로 지정된다).
어떤 구현예에서, 안티센스 화합물 또는 올리고뉴클레오타이드는 성장 호르몬 수용체 핵산의 인트론 8을 표적으로 한다. 어떤 측면에서, 안티센스 화합물 또는 올리고뉴클레오타이드는 하기의 핵염기 서열을 갖는 성장 호르몬 수용체 핵산의 뉴클레오타이드 292622-297153 (인트론 8) 내에서 표적화된다: 서열번호: 2 (GENBANK 승인번호 NT_006576.16, 뉴클레오타이드 42411001-42714000로부터 절단됨)로 지정된다).
어떤 구현예에서, 안티센스 화합물 또는 올리고뉴클레오타이드는 성장 호르몬 수용체 핵산의 인트론 9를 표적으로 한다. 어떤 측면에서, 안티센스 화합물 또는 올리고뉴클레오타이드는 하기의 핵염기 서열을 갖는 성장 호르몬 수용체 핵산의 뉴클레오타이드 297224-297554 (인트론 9) 내에서 표적화된다: 서열번호: 2 (GENBANK 승인번호 NT_006576.16, 뉴클레오타이드 42411001-42714000로부터 절단됨)로 지정된다).
어떤 구현예에서, 전술된 화합물 또는 올리고뉴클레오타이드 중 임의의 것은 적어도 하나의 변형된 당을 포함한다. 어떤 측면에서, 적어도 하나의 변형된 당은 2'-O-메톡시에틸 그룹을 포함한다. 어떤 측면에서, 적어도 하나의 변형된 당은 바이사이클릭 당, 예컨대 4'-CH(CH3)-O-2' 그룹, 4'-CH2-O-2' 그룹, 또는 4'-(CH2)2-O-2'그룹이다. 어떤 측면에서, 변형된 올리고뉴클레오타이드는 적어도 하나의 변형된 뉴클레오사이드간 연결, 예컨대 포스포로티오에이트 뉴클레오사이드간 연결을 포함한다.
어떤 구현예에서, 전술된 화합물 또는 올리고뉴클레오타이드 중 임의의 것은 적어도 하나의 변형된 핵염기, 예컨대 5-메틸시토신을 포함한다.
어떤 구현예에서, 전술된 화합물 또는 올리고뉴클레오타이드 중 임의의 것은 하기를 포함한다:
연결된 데옥시뉴클레오사이드로 이루어진 갭 분절;
연결된 뉴클레오사이드로 이루어진 5' 윙 분절; 및
연결된 뉴클레오사이드로 이루어진 3' 윙 분절;
상기 갭 분절은 5' 윙 분절과 3' 윙 분절 사이에 배치되고 여기서 각각의 윙 분절의 각각의 뉴클레오사이드는 변형된 당을 포함한다.
어떤 구현예는 하기에서 인용된 서열을 포함하는 핵염기 서열을 갖는 10-30개의 연결된 뉴클레오사이드로 이루어진 변형된 올리고뉴클레오타이드를 포함하는 화합물을 제공한다: 서열번호: 918, 479, 703, 1800, 1904, 2122, 2127, 또는 2194.
어떤 측면에서, 변형된 올리고뉴클레오타이드는 하기에서 인용된 서열을 포함하는 핵염기 서열을 갖는다: 서열번호: 918, 479 또는 703, 상기 변형된 올리고뉴클레오타이드는,
10개의 연결된 데옥시뉴클레오사이드로 이루어진 갭 분절;
5개의 연결된 뉴클레오사이드로 이루어진 5' 윙 분절; 및
5개의 연결된 뉴클레오사이드로 이루어진 3' 윙 분절;
상기 갭 분절은 상기 5' 윙 분절과 상기 3' 윙 분절 사이에 배치되고, 여기서 각각의 윙 분절의 각각의 뉴클레오사이드는 2'-O-메톡시에틸 당을 포함하고; 여기서 각각의 뉴클레오사이드간 연결은 포스포로티오에이트 연결이고, 여기서 각각의 시토신은 5-메틸시토신이다.
어떤 측면에서, 변형된 올리고뉴클레오타이드는 하기에서 인용된 서열을 포함하는 핵염기 서열을 갖는다: 서열번호: 1800, 1904, 2122, 2127, 또는 2194, 상기 변형된 올리고뉴클레오타이드는 하기를 포함하고:
10개의 연결된 데옥시뉴클레오사이드로 이루어진 갭 분절;
3개의 연결된 뉴클레오사이드로 이루어진 5' 윙 분절; 및
3개의 연결된 뉴클레오사이드로 이루어진 3' 윙 분절;
상기 갭 분절은 상기 5' 윙 분절과 상기 3' 윙 분절 사이에 배치되고, 여기서 각각의 윙 분절의 각각의 뉴클레오사이드는 2'-O-메톡시에틸 당 또는 구속된 에틸 당을 포함하고; 그리고 여기서 각각의 뉴클레오사이드간 연결은 포스포로티오에이트 연결이다.
어떤 구현예는 하기에서 인용된 서열로 이루어진 핵염기 서열을 갖는 20개의 연결된 뉴클레오사이드로 이루어진 변형된 올리고뉴클레오타이드를 포함하는 화합물을 제공한다: 서열번호: 703. 어떤 측면에서, 변형된 올리고뉴클레오타이드는 적어도 하나의 변형된 당을 포함한다. 어떤 측면에서, 적어도 하나의 변형된 당은 2'-O-메톡시에틸 그룹을 포함한다. 어떤 측면에서, 적어도 하나의 변형된 당은 바이사이클릭 당, 예컨대 4'-CH(CH3)-O-2' 그룹, 4'-CH2-O-2' 그룹, 또는 4'-(CH2)2-O-2'그룹이다. 어떤 측면에서, 변형된 올리고뉴클레오타이드는 적어도 하나의 변형된 뉴클레오사이드간 연결, 예컨대 포스포로티오에이트 뉴클레오사이드간 연결을 포함한다. 어떤 측면에서, 변형된 올리고뉴클레오타이드는 적어도 하나의 변형된 핵염기, 예컨대 5-메틸시토신을 포함한다. 어떤 측면에서, 변형된 올리고뉴클레오타이드는 하기를 포함한다:
연결된 데옥시뉴클레오사이드로 이루어진 갭 분절;
연결된 뉴클레오사이드로 이루어진 5' 윙 분절; 및
연결된 뉴클레오사이드로 이루어진 3' 윙 분절;
상기 갭 분절은 5' 윙 분절과 3' 윙 분절 사이에 배치되고 여기서 각각의 윙 분절의 각각의 뉴클레오사이드는 변형된 당을 포함한다.
어떤 구현예는 하기에서 인용된 서열로 이루어진 핵염기 서열을 갖는 20개의 연결된 뉴클레오사이드로 이루어진 변형된 올리고뉴클레오타이드를 포함하는 화합물을 제공한다: 서열번호: 703, 상기 변형된 올리고뉴클레오타이드는 하기를 포함하고:
10개의 연결된 데옥시뉴클레오사이드로 이루어진 갭 분절;
5개의 연결된 뉴클레오사이드로 이루어진 5' 윙 분절; 및
5개의 연결된 뉴클레오사이드로 이루어진 3' 윙 분절;
상기 갭 분절은 상기 5' 윙 분절과 상기 3' 윙 분절 사이에 배치되고; 여기서 각각의 윙 분절의 각각의 뉴클레오사이드는 2'-O-메톡시에틸 당을 포함하고; 여기서 각각의 뉴클레오사이드간 연결은 포스포로티오에이트 연결이고; 그리고 여기서 각각의 시토신은 5-메틸시토신이다.
전술된 구현예 중 임의의 것에서, 화합물 또는 올리고뉴클레오타이드는 성장 호르몬 수용체를 인코딩하는 핵산에 대해 적어도 85%, 적어도 90%, 적어도 95%, 적어도 98%, 적어도 99%, 또는 100% 상보적일 수 있다.
전술된 구현예 중 임의의 것에서, 성장 호르몬 수용체를 인코딩하는 핵산은 하기 중 임의의 하나의 뉴클레오타이드 서열을 포함할 수 있다: 서열번호: 1-19.
전술된 구현예 중 임의의 것에서, 화합물 또는 올리고뉴클레오타이드는 단일가닥일 수 있다.
어떤 구현예는 상기 언급된 구현예 중 임의의 것의 화합물 또는 그것의 염 및 약제학적으로 허용가능한 담체 또는 희석제 중 적어도 하나를 포함하는 조성물을 제공한다. 어떤 측면에서, 조성물은 약 40 센티푸아즈 (cP) 미만, 약 30 센티푸아즈 (cP) 미만, 약 20 센티푸아즈 (cP) 미만, 약 15 센티푸아즈 (cP) 미만, 또는 약 10 센티푸아즈 (cP) 미만의 점도를 갖는다. 어떤 측면에서, 상기 언급된 점도 중 어떤 것을 조성물은 본원에서 제공된 화합물을 약 100 mg/mL, 약 125 mg/mL, 약 150 mg/mL, 약 175 mg/mL, 약 200 mg/mL, 약 225 mg/mL, 약 250 mg/mL, 약 275 mg/mL, 또는 약 300 mg/mL의 농도로 포함한다. 어떤 측면에서, 상기 언급된 점도 및/또는 화합물 농도 중 어떤 것을 조성물은 실온 또는 약 20 ℃, 약 21 ℃, 약 22 ℃, 약 23 ℃, 약 24 ℃, 약 25 ℃, 약 26 ℃, 약 27 ℃, 약 28 ℃, 약 29 ℃, 또는 약 30°C의 온도를 갖는다.
어떤 구현예는 인간에서 과잉의 성장 호르몬과 연관된 질환을 치료하는 방법을 제공하고, 이 방법은 상기 인간에게 치료적으로 효과적인 양의 상기 언급된 구현예 중 임의의 것의 화합물 또는 조성물을 투여하고, 그렇게 함으로써 과잉의 성장 호르몬과 연관된 질환을 치료하는 단계를 포함한다. 특정 측면에서, 과량의 성장 호르몬과 관련된 질환은 말단 비대증이다. 어떤 측면에서, 치료는 IGF-1 수준을 감소시킨다.
어떤 구현예는 인간에서 과잉의 성장 호르몬과 연관된 질환을 예방하는 방법을 제공하고, 이 방법은 상기 인간에게 치료적으로 효과적인 양의 상기 언급된 구현예 중 임의의 것의 화합물 또는 조성물을 투여하고, 그렇게 함으로써 과잉의 성장 호르몬과 연관된 질환을 예방하는 단계를 포함한다. 어떤 구현예에서, 과잉의 성장 호르몬과 연관된 질환은 말단비대증이다.
어떤 구현예는 인간에서 성장 호르몬 수용체 (GHR) 수준을 감소시키는 방법을 제공하고, 이 방법은 상기 인간에게 치료적으로 효과적인 양의 상기 언급된 구현예 중 임의의 것의 화합물 또는 조성물을 투여하고, 그렇게 함으로써 인간에서 GHR 수준을 감소시키는 단계를 포함한다. 어떤 측면에서, 인간은 과잉의 성장 호르몬과 연관된 질환을 갖는다. 특정 측면에서, 과량의 성장 호르몬과 관련된 질환은 말단 비대증이다.
어떤 측면에서, 전술된 방법은 화합물 또는 조성물 및 제2 제제를 공-투여하는 것을 포함한다. 어떤 측면에서, 화합물 또는 조성물 및 상기 제2 제제는 부수적으로 투여된다.
안티센스 화합물
올리고머 화합물은, 비제한적으로 하기를 포함한다: 올리고뉴클레오타이드, 올리고뉴클레오사이드, 올리고뉴클레오타이드 유사체, 올리고뉴클레오타이드 모방체, 안티센스 화합물, 안티센스 올리고뉴클레오타이드, 및 siRNAs. 올리고머 화합물은 표적 핵산에 대해 "안티센스"일 수 있고, 이것은, 수소 결합을 통해 표적 핵산에 대해 하이브리드화를 경험할 수 있다는 것을 의미한다.
어떤 구현예에서, 안티센스 화합물은, 5' 내지 3' 방향으로 쓰여질 때, 표적화된 표적 핵산의 표적 분절의 역 보체를 포함하는 핵염기 서열을 갖는다. 어떤 그와 같은 구현예에서, 안티센스 올리고뉴클레오타이드는, 5' 내지 3' 방향으로 쓰여질 때, 표적화된 표적 핵산의 표적 분절의 역 보체를 포함하는 핵염기 서열을 갖는다.
어떤 구현예에서, 안티센스 화합물은, 그 길이가 10-30개의 서브유닛이다. 어떤 구현예에서, 안티센스 화합물은, 그 길이가 12 내지 30개의 서브유닛이다. 어떤 구현예에서, 안티센스 화합물은, 그 길이가 12 내지 22개의 서브유닛이다. 어떤 구현예에서, 안티센스 화합물은, 그 길이가 14 내지 30개의 서브유닛이다. 어떤 구현예에서, 안티센스 화합물은, 그 길이가 14 내지 20개의 서브유닛이다. 어떤 구현예에서, 안티센스 화합물은, 그 길이가 15 내지 30개의 서브유닛이다. 어떤 구현예에서, 안티센스 화합물은, 그 길이가 15 내지 20개의 서브유닛이다. 어떤 구현예에서, 안티센스 화합물은, 그 길이가 16 내지 30개의 서브유닛이다. 어떤 구현예에서, 안티센스 화합물은, 그 길이가 16 내지 20개의 서브유닛이다. 어떤 구현예에서, 안티센스 화합물은, 그 길이가 17 내지 30개의 서브유닛이다. 어떤 구현예에서, 안티센스 화합물은, 그 길이가 17 내지 20개의 서브유닛이다. 어떤 구현예에서, 안티센스 화합물은, 그 길이가 18 내지 30개의 서브유닛이다. 어떤 구현예에서, 안티센스 화합물은, 그 길이가 18 내지 21개의 서브유닛이다. 어떤 구현예에서, 안티센스 화합물은, 그 길이가 18 내지 20개의 서브유닛이다. 어떤 구현예에서, 안티센스 화합물은, 그 길이가 20-30개의 서브유닛이다. 환언하면, 그와 같은 안티센스 화합물은 하기이다: 12 내지 30개의 연결된 서브유닛, 14 내지 30개의 연결된 서브유닛, 14 내지 20 개의 서브유닛, 15 내지 30 개의 서브유닛, 15 내지 20 개의 서브유닛, 16 내지 30 개의 서브유닛, 16 내지 20 개의 서브유닛, 17 내지 30 개의 서브유닛, 17 내지 20 개의 서브유닛, 18 내지 30 개의 서브유닛, 18 내지 20 개의 서브유닛, 18 내지 21 서브유닛, 20-30 개의 서브유닛, 또는 12 내지 22 개의 연결된 서브유닛, 각각. 어떤 구현예에서, 안티센스 화합물은, 그 길이가 14개의 서브유닛이다. 어떤 구현예에서, 안티센스 화합물은, 그 길이가 16개의 서브유닛이다. 어떤 구현예에서, 안티센스 화합물은, 그 길이가 17개의 서브유닛이다. 어떤 구현예에서, 안티센스 화합물은, 그 길이가 18개의 서브유닛이다. 어떤 구현예에서, 안티센스 화합물은, 그 길이가 19개의 서브유닛이다. 어떤 구현예에서, 안티센스 화합물은, 그 길이가 20개의 서브유닛이다. 다른 구현예에서, 안티센스 화합물은 8 내지 80, 12 내지 50, 13 내지 30, 13 내지 50, 14 내지 30, 14 내지 50, 15 내지 30, 15 내지 50, 16 내지 30, 16 내지 50, 17 내지 30, 17 내지 50, 18 내지 22, 18 내지 24, 18 내지 30, 18 내지 50, 19 내지 22, 19 내지 30, 19 내지 50, 또는 20-30개의 연결된 서브유닛이다. 어떤 그와 같은 구현예에서, 안티센스 화합물은 그 길이가 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 또는 80개의 연결된 서브유닛이거나, 상기 값의 임의의 2개에 의해 정의된 범위이다. 일부 구현예에서 안티센스 화합물은 안티센스 올리고뉴클레오타이드이고, 그리고 상기 연결된 서브유닛은 뉴클레오타이드이다.
어떤 구현예에서 안티센스 올리고뉴클레오타이드는 단축되거나 끝이 잘릴 수 있다. 예를 들면, 단일 서브유닛은 5' 말단 (5' 절단)으로부터, 또는 대안적으로 3' 말단 (3' 절단)으로 결실될 수 있다. 단축된 또는 끝이 잘린 GHR 핵산에 대해 표적화된 안티센스 화합물은 안티센스 화합물의 5' 말단으로부터 2개의 서브유릿을 가질 수 있고, 또는 대안적으로 3' 말단으로부터 결실된 2개의 서브유닛을 가질 수 있다. 대안적으로, 결실된 뉴클레오사이드는, 예를 들면, 5' 말단으로부터 결실된 하나의 뉴클레오사이드 및 3' 말단으로부터 결실된 하나의 뉴클레오사이드를 갖는 안티센스 화합물에서 안티센스 화합물 도처에 분산될 수 있다.
단일 추가의 서브유닛이 늘어난 안티센스 화합물에서 존재할 때, 추가의 서브유닛은 안티센스 화합물의 5' 또는 3' 말단에서 위치할 수 있다. 2 이상 추가의 서브유닛이 존재할 때, 부가된 서브유닛은, 예를 들면, 안티센스 화합물의 5' 말단에 부가된 2개의 서브유닛 (5' 부가), 또는 대안적으로 3' 말단에 부가된 2개의 서브유릿 (3' 부가)를 갖는 안티센스 화합물에서 서로 인절할 수 있다. 대안적으로, 부가된 서브유닛은, 예를 들면, 5' 말단에 부가된 하나의 서브유닛 및 3' 말단에 부가된 하나의 서브유닛을 갖는 안티센스 화합물에서 안티센스 화합물 도처에 분산될 수 있다.
안티센스 화합물, 예컨대 안티센스 올리고뉴클레오타이드의 길이를 증가 또는 감소시키고/거나 활성을 제거하지 않으면서 미스매치 염기를 도입할 수 있다. 예를 들면, Woolf 등 (Proc. Natl. Acad. Sci. USA 89:7305-7309, 1992)에서, 그 길이가13-25개의 핵염기인 일련의 안티센스 올리고뉴클레오타이드는 난모세포 주사 모델에서 표적 RNA의 절단을 도입하기 위한 그것의 능력에 대해 시험되었다. 안티센스 올리고뉴클레오타이드의 말단 근처의 8 또는 11개의 미스매치 염기의 길이를 갖는 안티센스 올리고뉴클레오타이드 25개의 핵염기는 미스매치를 보유하지 않는 안티센스 올리고뉴클레오타이드보다 도 적은 정도로 표적 mRNA의 특정 절단을 유도할 수 있다. 유사하게, 표적 특이적 절단은 1 또는 3개의 미스매치를 포함하는 13개의 핵염기 안티센스 올리고뉴클레오타이드를 사용하여 달성되었다.
Gautschi 등. (J. Natl. Cancer Inst. 93:463-471, March 2001)은 bcl-2 mRNA에 대해 100% 상보성을 갖고 bcl-2 및 bcl-xL 시험관내 및 생체내 둘 모두의 발현을 감소시키기 위해 bcl-xL mRNA에 대한 3개의 미스매치를 갖는 올리고뉴클레오타이드의 능력을 실증했다. 더욱이, this 올리고뉴클레오타이드 강력한 항종양 활성을 생체내에서 실증했다.
Maher 및 Dolnick (Nuc. Acid. Res. 16:3341-3358,1988)는 일련의 탠덤 14개의 핵염기 안티센스 올리고뉴클레오타이드를 시험했고, 28 및 42개의 핵염기 안티센스 올리고뉴클레오타이드는 토끼 망상적혈구 분석에서 인간 DHFR의 번역을 체포하는 그것의 능력에 대해 탠덤 안티센스 올리고뉴클레오타이드의 2개 또는 3개, 각각의 서열로 구성된다. 각각의 3 내지 14개의 핵염기 안티센스 올리고뉴클레오타이드 단독은 28 또는 42개의 핵염기 안티센스 올리고뉴클레오타이드보다 더 보통의 수준에서도 번역을 억제할 수 있었다.
어떤 안티센스 화합물 모티프 및 기전
어떤 구현예에서, 안티센스 화합물은, 안티센스 화합물 특성 예컨대 증대된 억제 활성, 표적 핵산에 대핸 증가된 결합 친화도, 또는 생체내 뉴클레아제에 의한 분해에 대한 내성을 부여하기 위해 패턴, 또는 모티프에서 마련된 화학적으로 변형된 서브유닛을 갖는다.
키메라성 안티센스 화합물은 전형적으로 뉴클레아제 분해에 대한 증가된 내성, 증가된 세포성 흡수, 표적 핵산에 대한 증가된 결합 친화도, 및/또는 증가된 억제 활성을 부여하기 위해 변형된 적어도 하나의 영역을 함유한다. 키메라성 안티센스 화합물의 제2 영역은 또 하나의 원하는 특성을 부여할 수 있고, 예를 들면, RNA:DNA 듀플렉스의 RNA 가닥을 절단하는 세포성 엔도뉴클레아제 RNase H에 대한 대체물로서 쓰인다.
안티센스 활성은 안티센스 화합물 (예를 들면, 올리고뉴클레오타이드)과 표적 핵산과의 하이브리드화를 수반하는 임의의 기전으로부터 유래할 수 있고, 상기 하이브리드화는 궁극적으로 생물학적 효과를 야기한다. 어떤 구현예에서, 표적 핵산의 양 및/또는 활성이 조절된다. 어떤 구현예에서, 표적 핵산의 양 및/또는 활성이 감소된다. 어떤 구현예에서, 안티센스 화합물의 표적 핵산에의 하이브리드화는 표적 핵산 분해를 야기하지 않는다. 어떤 구현예에서, 안티센스 화합물의 표적 핵산에의 하이브리드화는 표적 핵산 분해를 야기하지 않는다. 어떤 그와 같은 구현예에서, 표적 핵산 (점유)과 혼성화된 안티센스 화합물의 존재는 안티센스 활성의 조절을 야기한다. 어떤 구현예에서, 특정한 화학적 모티프 또는 화학적 변형의 패턴을 갖는 안티센스 화합물은 하나 이상의 기전을 활용하는데 특히 적합하다. 어떤 구현예에서, 안티센스 화합물은 1 초과의 기전을 통해 기능하고/거나 설명되지 않았던 기전을 통해 기능한다. 따라서, 본원에서 기재된 안티센스 화합물은 특정한 기전에 의해 제한되지 않는다.
안티센스 기전는, 비제한적으로 하기를 포함한다: RNase H 매개된 안티센스; RISC 경로를 이용하고 siRNA, ssRNA 및 microRNA 기전을 비제한적으로 포함하는 RNAi 기전; 및 점유 기반 기전. 어떤 안티센스 화합물은 1 초과 그와 같은 기전을 통해 및/또는 추가의 기전을 통해 작용할 수 있다.
RNase H- 매개된 안티센스
어떤 구현예에서, 안티센스 활성은 RNase H에 의한 표적 RNA의 분해로부터 적어도 부번적으로 유래한다. RNase H는 RNA:DNA 듀플렉스의 RNA 가닥을 절단하는 세포성 엔도뉴클레아제이다. "DNA-유사"인 단일가닥 안티센스 화합물이 포유동물 세포에서 RNase H 활성을 유도한다는 것이 당해기술에서 공지되어 있다. 따라서, 적어도 일부의 DNA 또는 DNA-유사 뉴클레오사이드를 포함하는 인티센스 화합물은 RNase H를 활성화시킬 수 있고, 이것으로 표적 핵산가 절단된다. 어떤 구현예에서, RNase H 를 이용하는 안티센스 화합물은 하나 이상의 변형된 뉴클레오사이드를 포함한다. 어떤 구현예에서, 그와 같은 안티센스 화합물은 1-8개의 변형된 뉴클레오사이드 중 적어도 하나의 블록을 포함한다. 어떤 그와 같은 구현예에서, 변형된 뉴클레오사이드는 RNase H 활성을 지지하지 않는다. 어떤 구현예에서, 그와 같은 안티센스 화합물은 본원에 기재된 바와 같은 캡머이다. 어떤 그와 같은 구현예에서, 상기 갭머의 갭은 DNA 뉴클레오사이드를 포함한다. 어떤 그와 같은 구현예에서, 상기 갭머의 갭은 DNA-유사 뉴클레오사이드를 포함한다. 어떤 그와 같은 구현예에서, 상기 갭머의 갭은 DNA 뉴클레오사이드 및 DNA-유사 뉴클레오사이드를 포함한다.
갭머 모티프를 갖는 어떤 안티센스 화합물은 키메라성 안티센스 화합물인 것으로 간주된다. 갭머에서 RNaseH 절단을 기지하는 복수의 뉴클레오타이드를 갖는 내부 영역은 내부 영역의 뉴클레오사이드으로부터 화학적으로 뚜렷이 다른 복수의 뉴클레오타이드를 갖는 외부 영역 사이에 배치된다. 갭머 모티프를 갖는 안티센스 올리고뉴클레오타이드의 경우에, 갭 분절은 일반적으로 엔도뉴클레아제 절단에 대핸 대체물로서 쓰이지만, 윙 분절은 변형된 뉴클레오사이드를 포함한다. 어떤 구현예에서, 갭머의 영역은 각각의 뚜렷이 다른 영역을 포함하는 당 모이어티의 유형에 의해 분화된다. 갭머의 영역을 분화시키기 위해 사용되는 당 모이어티의 유형은 일부 구현예에서 하기를 포함할 수 있다: β-D-리보뉴클레오사이드, β-D-데옥시리보뉴클레오사이드, 2'-변형된 뉴클레오사이드 (그와 같은 2'-변형된 뉴클레오사이드는, 기타 중에서 2'-MOE 및 2'-O-CH3를 포함할 수 있다), 및 바이사이클릭 당 변형된 뉴클레오사이드 (그와 같은 바이사이클릭 당 변형된 뉴클레오사이드는 구속된 에틸을 갖는 것들을 포함할 수 있다). 어떤 구현예에서, 윙 중 뉴클레오사이드는, 예를 들면 2'-MOE 및 바이사이클릭 당 모이어티 예컨대 구속된 에틸 또는 LNA을 포함하는, 몇 개의 변형된 당 모이어티를 포함할 수 있다. 어떤 구현예에서, 윙은 몇 개의 변형된 및 비변형된 당 모이어티를 포함할 수 있다. 어떤 구현예에서, 윙은 2'-MOE 뉴클레오사이드, 바이사이클릭 당 모이어티 예컨대 구속된 에틸 뉴클레오사이드 또는 LNA 뉴클레오사이드, 및 2'-데옥시뉴클레오사이드의 다양한 조성물을 포함할 수 있다.
각각의 뚜렷이 다른 영역은 균일한 당 모이어티, 변이체, 또는 교대 당 모이어티를 포함할 수 있다. 윙 -갭-윙 모티프는 빈번하게 "X-Y-Z"로서 기재되고, 여기서 "X"는 5'-윙의 길이를 나타내고, "Y"는 갭의 길이를 나타내고, 그리고 "Z"는 3'-윙의 길이를 나타낸다. "X" 및 "Z"는 균일한, 변이체, 또는 교대 당 모이어티를 포함할 수 있다. 어떤 구현예에서, "X" 및 "Y"는 하나 이상의 2'-데옥시뉴클레오사이드를 포함할 수 있다. "Y"는 2'-데옥시뉴클레오사이드를 포함할 수 있다. 본원에서 사용된 바와 같이, "X-Y-Z"로서 기재된 갭머는 입체배치를 가지며, 이로써 갭은 각각의 5'-윙 및 3' 윙에 바로 인접하여 배치된다. 따라서, 중재 뉴클레오타이드는 5'-윙 및 갭, 또는 갭 및 3'-윙 사이에 존재하지 않는다. 본원에서 기재된 안티센스 화합물 중 어떤 것은 갭머 모티프를 가질 수 있다. 어떤 구현예에서, "X" 및 "Z"는 동일하고; 다른 구현예에서 상이하다. 어떤 구현예에서, "Y"는 8 내지 15개의 뉴클레오사이드이다. X, Y, 또는 Z는 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 25, 30 또는그 초과의 뉴클레오사이드 중 임의의 것일 수 있다.
어떤 구현예에서, GHR 핵산에 대해 표적화된 안티센스 화합물은, 갭이 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 또는 16개의 연결된 뉴클레오사이드로 구성된 갭머 모티프를 갖는다.
어떤 구현예에서, 안티센스 올리고뉴클레오타이드는 하기와 같이 식 A에 의해 기재된 당 모티프를 갖는다: (J)m-(B)n-(J)p-(B)r-(A)t-(D)g-(A)v-(B)w-(J)x-(B)y-(J)z
여기서:
각각의 A는 독립적으로 2'-치환된 뉴클레오사이드이고;
각각의 B는 독립적으로 바이사이클릭 뉴클레오사이드이고;
각각의 J는 독립적으로 2'-치환된 뉴클레오사이드 또는 2'-데옥시뉴클레오사이드이고;
각각의 D는 2'-데옥시뉴클레오사이드이고;
m는 0-4이고; n는 0-2이고; p는 0-2이고; r는 0-2이고; t는 0-2이고; v는 0-2이고; w는 0-4이고; X는 0-2이고; y는 0-2이고; z는 0-4이고; G는 6-14이고;
단:
m, n, 및 r 중 적어도 하나는 0 이외의 것이고;
w 및 y 중 적어도 하나는 0 이외의 것이고;
m, n, p, r, 및 t의 합은 2 내지 5이고; 그리고
v, w, x, y, 및 z의 합은 2 내지 5이다.
RNAi 화합물
어떤 구현예에서, 안티센스 화합물은 이중-가닥 RNA 화합물 (또한 일명 단-간섭 RNA 또는 siRNA) 및 단일가닥 RNAi 화합물 (또는 ssRNA)를 포함하는 간섭 RNA 화합물 (RNAi)이다. 그와 같은 화합물은 표적 핵산을 분해 및/또는 격리하기 위해 RISC 경로를 통해 적어도 부분적으로 작용한다 (따라서, 마이크로RNA/마이크로RNA-모방 화합물을 포함한다). 어떤 구현예에서, 안티센스 화합물은 그와 같은 기전에 특히 적합하도록 하기 위한 변형을 포함한다.
i. ssRNA 화합물
어떤 구현예에서, 단일가닥 RNAi 화합물 (ssRNA)로서 사용하는데 특히 적합한 것들을 포함하는 안티센스 화합물은 변형된 5'-말단을 포함한다. 어떤 그와 같은 구현예에서, 5'-말단은 변형된 포스페이트 모이어티를 포함한다. 어떤 구현예에서, 그와 같은 변형된 포스페이트는 안정된다 (예를 들면, 비변형된 5'-포스페이트와 비교하여 분해/절단에 대해 내성이 있다). 어떤 구현예에서, 그와 같은 5'-말단 뉴클레오사이드는 5'-인 모이어티를 안정화시킨다. 어떤 변형된 5'-말단 뉴클레오사이드는 당해기술, 예를 들면 WO/2011/139702에서 발견될 수 있다.
어떤 구현예에서, ssRNA 화합물의 5'-뉴클레오사이드는 식 IIc를 갖는다:
Figure 112016006891241-pct00002
여기서:
T1는 임의로 보호된 인 모이어티이고;
T2는 IIc의 화합물을 올리고머 화합물에 연결시키는 뉴클레오사이드간 연결 그룹이다;
A는 아래의 식 중 하나를 갖는다:
Figure 112016006891241-pct00003
또는
Figure 112016006891241-pct00004
Q1 및 Q2 각각은, 독립적으로, H, 할로겐, C1-C6 알킬, 치환된 C1-C6 알킬, C1-C6 알콕시, 치환된 C1-C6 알콕시, C2-C6 알케닐, 치환된 C2-C6 알케닐, C2-C6 알키닐, 치환된 C2-C6 알키닐 또는 N(R3)(R4)이고;
Q3는 O, S, N(R5) 또는 C(R6)(R7)이고;
각각의 R3, R4 R5, R6 및 R7는, 독립적으로, H, C1-C6 알킬, 치환된 C1-C6 알킬 또는 C1-C6 알콕시이고;
M3는 O, S, NR14, C(R15)(R16), C(R15)(R16)C(R17)(R18)이, C(R15)=C(R17), OC(R15)(R16) 또는 OC(R15)(Bx2)이고;
R14는 H, C1-C6 알킬, 치환된 C1-C6 알킬, C1-C6 알콕시, 치환된 C1-C6 알콕시, C2-C6 알케닐, 치환된 C2-C6 알케닐, C2-C6 알키닐 또는 치환된 C2-C6 알키닐이고;
R15, R16, R17 및 R18 각각은, 독립적으로, H, 할로겐, C1-C6 알킬, 치환된 C1-C6 알킬, C1-C6 알콕시, 치환된 C1-C6 알콕시, C2-C6 알케닐, 치환된 C2-C6 알케닐, C2-C6 알키닐 또는 치환된 C2-C6 알키닐이고;
Bx1은 헤테로사이클릭 염기 모이어티이고;
또는 Bx2가 존재한다면, 이때 Bx2은 헤테로사이클릭 염기 모이어티 및 Bx1는 H, 할로겐, C1-C6 알킬, 치환된 C1-C6 알킬, C1-C6 알콕시, 치환된 C1-C6 알콕시, C2-C6 알케닐, 치환된 C2-C6 알케닐, C2-C6 알키닐 또는 치환된 C2-C6 알키닐이고;
J4, J5, J6 및 J7 각각은, 독립적으로, H, 할로겐, C1-C6 알킬, 치환된 C1-C6 알킬, C1-C6 알콕시, 치환된 C1-C6 알콕시, C2-C6 알케닐, 치환된 C2-C6 알케닐, C2-C6 알키닐 또는 치환된 C2-C6 알키닐이고;
또는 J4는 J5 또는 J7 중 하나를 갖는 브릿지를 형성하고, 상기 브릿지는 O, S, NR19, C(R20)(R21), C(R20)=C(R21), C[=C(R20)(R21)] 및 C(=O) 로부터 선택된 1-3개의 연결된 2가 라디칼 그룹을 포함하고, J5, J6 및 J7 각각 중 다른 2개는, 독립적으로, H, 할로겐, C1-C6 알킬, 치환된 C1-C6 알킬, C1-C6 알콕시, 치환된 C1-C6 알콕시, C2-C6 알케닐, 치환된 C2-C6 알케닐, C2-C6 알키닐 또는 치환된 C2-C6 알키닐이고;
각각의 R19, R20 및 R21는, 독립적으로, H, C1-C6 알킬, 치환된 C1-C6 알킬, C1-C6 알콕시, 치환된 C1-C6 알콕시, C2-C6 알케닐, 치환된 C2-C6 알케닐, C2-C6 알키닐 또는 치환된 C2-C6 알키닐이고;
G은 H, OH, 할로겐 또는 O-[C(R8)(R9)]n-[(C=O)m-X1]j-Z이고;
각각의 R8 및 R9는, 독립적으로, H, 할로겐, C1-C6 알킬 또는 치환된 C1-C6 알킬이고;
X1는 O, S 또는 N(E1)이고;
Z은 H, 할로겐, C1-C6 알킬, 치환된 C1-C6 알킬, C2-C6 알케닐, 치환된 C2-C6 알케닐, C2-C6 알키닐, 치환된 C2-C6 알키닐 또는 N(E2)(E3)이고;
E1, E2 및 E3 각각은, 독립적으로, H, C1-C6 알킬 또는 치환된 C1-C6 알킬이고;
n은 1-약 6이고;
m는 0 또는 1이고;
J는 0 또는 1이고;
각각의 치환된 그룹은 하기로부터 독립적으로 선택된 하나 이상의 임의로 보호된 치환체 그룹을 포함한다: 할로겐, OJ1, N(J1)(J2), =NJ1, SJ1, N3, CN, OC(=X2)J1, OC(=X2)-N(J1)(J2) 및 C(=X2)N(J1)(J2);
X2는 O, S 또는 NJ3이고;
각각의 J1, J2 및 J3는, 독립적으로, H 또는 C1-C6 알킬이고;
J가 1이면, 이때 Z는 할로겐 또는 N(E2)(E3)이외의 것이고; 그리고
상기 올리고머 화합물은 8 내지 40개의 모노머 서브유닛을 포함하고 적어도 일부의 표적 핵산과 혼성화가능하다.
어떤 구현예에서, M3는 O, CH=CH, OCH2 또는 OC(H)(Bx2)이다. 어떤 구현예에서, M3는 O이다.
어떤 구현예에서, J4, J5, J6 및 J7 각각은 H이다. 어떤 구현예에서, J4는 J5 또는 J7 중 하나를 갖는 브릿지를 형성한다.
어떤 구현예에서, A는 아래의 식 중 하나를 갖는다:
Figure 112016006891241-pct00005
또는
Figure 112016006891241-pct00006
여기서:
Q1 및 Q2 각각은, 독립적으로, H, 할로겐, C1-C6 알킬, 치환된 C1-C6 알킬, C1-C6 알콕시 또는 치환된 C1-C6 알콕시이다. 어떤 구현예에서, Q1 및 Q2 각각은 H이다. 어떤 구현예에서, Q1 및 Q2 각각은, 독립적으로, H 또는 할로겐이다. 어떤 구현예에서, Q1 및 Q2는 H이고 Q1 및 Q2 중 다른 것은 F, CH3 또는 OCH3이다.
어떤 구현예에서, T1은 아래의 식을 갖는다:
Figure 112016006891241-pct00007
여기서:
Ra 및 Rc 각각은, 독립적으로, 보호된 하이드록실, 보호된 티올, C1-C6 알킬, 치환된 C1-C6 알킬, C1-C6 알콕시, 치환된 C1-C6 알콕시, 보호된 아미노 또는 치환된 아미노이고; 그리고
Rb는 O 또는 S이다. 어떤 구현예에서, Rb는 O이고 Ra 및 Rc 각각은, 독립적으로, OCH3, OCH2CH3 또는 CH(CH3)2이다.
어떤 구현예에서, G는 할로겐, OCH3, OCH2F, OCHF2, OCF3, OCH2CH3, O(CH2)2F, OCH2CHF2, OCH2CF3, OCH2-CH=CH2, O(CH2)2-OCH3, O(CH2)2-SCH3, O(CH2)2-OCF3, O(CH2)3-N(R10)(R11), O(CH2)2-ON(R10)(R11), O(CH2)2-O(CH2)2-N(R10)(R11), OCH2C(=O)-N(R10)(R11), OCH2C(=O)-N(R12)-(CH2)2-N(R10)(R11) 또는 O(CH2)2-N(R12)-C(=NR13)[N(R10)(R11)]이고, 여기서 R10, R11, R12 및 R13 각각은, 독립적으로, H 또는 C1-C6 알킬이다. 어떤 구현예에서, G는 할로겐, OCH3, OCF3, OCH2CH3, OCH2CF3, OCH2-CH=CH2, O(CH2)2-OCH3, O(CH2)2-O(CH2)2-N(CH3)2, OCH2C(=O)-N(H)CH3, OCH2C(=O)-N(H)-(CH2)2-N(CH3)2 또는 OCH2-N(H)-C(=NH)NH2이다. 어떤 구현예에서, G는 F, OCH3 또는 O(CH2)2-OCH3이다. 어떤 구현예에서, G는 O(CH2)2-OCH3이다.
어떤 구현예에서, 5'-말단 뉴클레오사이드는 식 IIe를 갖는다:
Figure 112016006891241-pct00008
어떤 구현예에서, ssRNA에 대해 특히 적합한 것을 포함하는 안티센스 화합물은 정의된 패턴 또는 당 변형 모티프에서 올리고뉴클레오타이드와 함께 마련된 변형된 당 모이어티 및/또는 천연 발생 당 모이어티 또는 그것의 영역 중 하나 이상의 유형을 포함한다. 그와 같은 모티프는 본원에서 논의된 당 변형 및/또는 다른 공지된 당 변형 중 임의의 것을 포함할 수 있다.
그와 같은 모니프는 본원에서 논의된 당 변형 및/또는 다른 공지된 당 변형 중 임의의 것을 포함할 수 있다. 어떤 그와 같은 구현예에서, 상기 영역의 각각의 뉴클레오사이드는 동일한 RNA-유사 당 변형을 포함한다. 어떤 구현예에서, 상기 영역의 각각의 뉴클레오사이드는 2'-F 뉴클레오사이드이다. 어떤 구현예에서, 상기 영역의 각각의 뉴클레오사이드는 2'-OMe 뉴클레오사이드이다. 어떤 구현예에서, 상기 영역의 각각의 뉴클레오사이드는 2'-MOE 뉴클레오사이드이다. 어떤 구현예에서, 상기 영역의 각각의 뉴클레오사이드는 cEt 뉴클레오사이드이다. 어떤 구현예에서, 상기 영역의 각각의 뉴클레오사이드는 LNA 뉴클레오사이드이다. 어떤 구현예에서, 균일한 영역은 모든 또는 본질적으로 모든 올리고뉴클레오타이드를 구성한다. 어떤 구현예에서, 영역은 1-4개의 말단 뉴클레오사이드를 제외하고 전체 올리고뉴클레오타이드를 구성한다.
어떤 구현예에서, 올리고뉴클레오타이드는 교대 당 변형의 하나 이상의 영역을 포함하고, 상기 뉴클레오사이드는 제1 유형의 당 변형을 갖는 뉴클레오타이드 및 제2 유형의 당 변형을 갖는 뉴클레오타이드 둘 사이을 오간다. 어떤 구현예에서, 둘 유형 모두의 뉴클레오사이드는 RNA-유사 뉴클레오사이드이다. 어떤 구현예에서 교대 뉴클레오사이드는 하기로부터 선택된다: 2'-OMe, 2'-F, 2'-MOE, LNA, 및 cEt. 어떤 구현예에서, 교대 변형은 2'-F 및 2'-OMe이다. 그와 같은 영역은 인접될 수 있거나 상이하게 변형된 뉴클레오사이드 또는 접합된 뉴클레오사이드에 의해 방해될 수 있다.
어떤 구현예에서, 교대 변형 각각의 교대 영역은 단일 뉴클레오사이드로 구성된다 (즉, 패턴은 (AB)xAy이고, 여기서 A는 제1 유형의 당 변형을 갖는 뉴클레오사이드이고 B는 제2 유형의 당 변형을 갖는 뉴클레오사이드이고; X는 1-20이고 y는 0 또는 1이다). 어떤 구현예에서, 교대 모티프 중 하나 이상의 교대 영역은 단일 초과의 뉴클레오사이드의 유형을 포함한다. 예를 들면, 올리고뉴클레오타이드 는 하기 뉴클레오사이드 모티프 중 임의의 것 중 하나 이상의 영역을 포함할 수 있다:
AABBAA;
ABBABB;
AABAAB;
ABBABAABB;
ABABAA;
AABABAB;
ABABAA;
ABBAABBABABAA;
BABBAABBABABAA; 또는
ABABBAABBABABAA;
여기서 A는 제1 유형의 뉴클레오사이드이고 B는 제2 유형의 뉴클레오사이드이다. 어떤 구현예에서, A 및 B 각각은 2'-F, 2'-OMe, BNA, 및 MOE로부터 선택된다.
어떤 구현예에서, 그와 같은 교대 모티프를 갖는 올리고뉴클레오타이드는 변형된 5' 말단 뉴클레오사이드, 예컨대 식 IIc 또는 IIe의 것들 것 또한 포함한다.
어떤 구현예에서, 올리고뉴클레오타이드는 2-2-3 모티프을 갖는 영역을 포함한다. 그와 같은 영역은 하기 모티프를 포함한다:
-(A)2-(B)x-(A)2-(C)y-(A)3-
여기서: A는 제1 유형의 변형된 뉴클레오사이드이고;
B 및 C는, A보다 상이하게 변형된 뉴클레오사이드이고, 그러나, B 및 C는 서로 동일 또는 상이한 변형을 가질 수 있고;
x 및 y는 1-15이다.
어떤 구현예에서, A는 2'-OMe 변형된 뉴클레오사이드이다. 어떤 구현예에서, B 및 C 둘 모두는 2'-F 변형된 뉴클레오사이드이다. 어떤 구현예에서, A는 2'-OMe 변형된 뉴클레오사이드이고 B 및 C 둘 모두는 2'-F 변형된 뉴클레오사이드이다.
어떤 구현예에서, 올리고뉴클레오사이드는 하기 당 모티프를 갖는다:
5'- (Q)- (AB)xAy-(D)z
여기서:
Q는 안정된 포스페이트 모이어티를 포함하는 뉴클레오사이드이다. 어떤 구현예에서, Q은 식 IIc 또는 IIe를 갖는 뉴클레오사이드이고;
A는 제1 유형의 변형된 뉴클레오사이드이고;
B는 제2 유형의 변형된 뉴클레오사이드;
D은 그것에 인접한 뉴클레오사이드로부터 상이한 변형을 포함하는 변형된 뉴클레오사이드이다. 따라서, y가 0이면, 이때 D는 B보다 상이하게 변형되어야 하고, y가 1이면, 이때 D는 A보다 상이하게 변형되어야 한다. 어떤 구현예에서, D는 A 및 B 모두로부터 상이하다.
X는 5 내지 15이고,
Y는 0 또는 1이고;
Z는 0-4이다.
어떤 구현예에서, 올리고뉴클레오사이드는 하기 당 모티프를 갖는다:
5'- (Q)- (A)x-(D)z
여기서:
Q는 안정된 포스페이트 모이어티를 포함하는 뉴클레오사이드이다. 어떤 구현예에서, Q은 식 IIc 또는 IIe를 갖는 뉴클레오사이드이고;
A는 제1 유형의 변형된 뉴클레오사이드이고;
D은 A로부터 상이한 변형을 포함하는 변형된 뉴클레오사이드이다.
X는 11-30이고;
Z는 0-4이다.
어떤 구현예에서 상기 모티프 중 A, B, C, 및 D는 하기로부터 선택된다: 2'-OMe, 2'-F, 2'-MOE, LNA, 및 cEt. 어떤 구현예에서, D는 말단 뉴클레오사이드를 나타낸다. 어떤 구현예에서, 그와 같은 말단 뉴클레오사이드는 표적 핵산에 혼성화하도록 설계되지 않는다 (하지만 하나 이상은 우연히 혼성화한다). 어떤 구현예에서, 각각의 D 뉴클레오사이드의 핵염기는, 표적 핵산의 상응하는 위치에서 핵염기의 동일성과는 무관하게 아데닌이다. 어떤 구현예에서 각각의 D 뉴클레오사이드의 핵염기는 티민이다.
어떤 구현예에서, ssRNA로서 사용하는데 특히 적합한 것을 포함하는 안티센스 화합물은 정의된 패턴 또는 변형된 뉴클레오사이드간 연결 모티프에서 올리고뉴클레오타이드 또는 그것의 영역을 따라 마련된 변형된 뉴클레오사이드간 연결을 포함한다. 어떤 구현예에서, 올리고뉴클레오타이드는 교대 뉴클레오사이드간 연결 모티프를 갖는 영역을 포함한다. 어떤 구현예에서, 올리고뉴클레오타이드는 균일하게 변형된 뉴클레오사이드간 연결의 영역을 포함한다. 어떤 그와 같은 구현예에서, 올리고뉴클레오타이드는 포스포로티오에이트 뉴클레오사이드간 연결에 의해 균일하게 연결된 영역을 포함한다. 어떤 구현예에서, 올리고뉴클레오타이드는 포스포로-티오에이트 뉴클레오사이드간 연결에 의해 균일하게 연결된다. 어떤 구현예에서, 올리고뉴클레오타이드의 각각의 뉴클레오사이드간 연결은 포스포디에스테르 및 포스포로-티오에이트로부터 선택된다. 어떤 구현예에서, 올리고뉴클레오타이드의 각각의 뉴클레오사이드간 연결은 포스포디에스테르 및 포스포로-티오에이트로부터 선택되고 및 적어도 하나의 뉴클레오사이드간 연결은 포스포로-티오에이트이다.
어떤 구현예에서, 올리고뉴클레오타이드는 적어도 6개의 포스포로-티오에이트 뉴클레오사이드간 연결을 포함한다. 어떤 구현예에서, 올리고뉴클레오타이드는 적어도 8개의 포스포로티오에이트 뉴클레오사이드간 연결을 포함한다. 어떤 구현예에서, 올리고뉴클레오타이드는 적어도 10개의 포스포로-티오에이트 뉴클레오사이드간 연결을 포함한다. 어떤 구현예에서, 올리고뉴클레오타이드는 적어도 6개의 연속적인 포스포로-티오에이트 뉴클레오사이드간 연결의 적어도 하나의 블록을 포함한다. 어떤 구현예에서, 올리고뉴클레오타이드는 적어도 8개의 연속적인 포스포로-티오에이트 뉴클레오사이드간 연결의 적어도 하나의 블록을 포함한다. 어떤 구현예에서, 올리고뉴클레오타이드는 적어도 10개의 연속적인 포스포로-티오에이트 뉴클레오사이드간 연결의 적어도 하나의 블록을 포함한다. 어떤 구현예에서, 올리고뉴클레오타이드는 적어도 하나의 12 연속적인 포스포로-티오에이트 뉴클레오사이드간 연결의 적어도 하나의 블록을 포함한다. 어떤 그와 같은 구현예에서, 적어도 하나의 그와 같은 블록은 올리고뉴클레오타이드의 3' 말단에서 위치한다. 어떤 그와 같은 구현예에서, 적어도 하나의 그와 같은 블록은 올리고뉴클레오타이드의 3' 말단의 3개의 뉴클레오사이드 내에 위치한다.
본원에서 기재된 다양한 당 모티프 중 임의의 것을 갖는 올리고뉴클레오타이드는 임의의 연결 모티프를 가질 수 있다. 상기에서 기재된 것들을 비제한적으로 포함하는, 예를 들면, 올리고뉴클레오타이드는, 아래의 비제한적인 표로부터 선택된 연결 모티프를 가질 수 있다:
Figure 112016006891241-pct00009
ii. siRNA 화합물
특정 구현예에서, 안티센스 화합물은 이중나선 RNAi 화합물 (siRNA)이다. 상기 구현예에서, 하나 또는 양 가닥은 ssRNA를 위해 상기된 임의의 변형 모티프를 포함할 수 있다. 특정 구현예에서, ssRNA 화합물은 비변형된 RNA일 수 있다. 특정 구현예에서, siRNA 화합물은 비변형된 RNA 뉴클레오사이드 및 변형된 뉴클레오사이드 상호 연결체를 포함할 수 있다.
여러 구현예는 이중가닥 조성물에 관한 것이고, 여기서, 각각의 가닥은 하나 이상의 변형되거나 비변형된 뉴클레오사이드의 위치에 의해 정의되는 모티프를 포함한다. 특정 구현예에서, 이중나선 영역을 형성하기 위해 완전히 또는 적어도 부분적으로 하이브리드화하는 제1 및 제2 올리고머 화합물을 포함하고 핵산 표적에 상보적이고 여기에 하이브리드화하는 영역을 추가로 포함하는 조성물이 제공된다. 상기 조성물은 핵산 표적에 완전하거나 부분적 상보성을 갖는 안티센스 가닥인 제1 올리고머 화합물 및 제1 올리고머 화합물에 대한 하나 이상의 상보성 영역을 가져 적어도 하나의 이중나선 영역을 형성하는 센스 가닥인 제2 올리고머 화합물을 포함하는 것이 적합하다.
여러 구현예의 조성물은 핵산 표적에 하이브리드화하여 이의 정상 기능을 상실시킴에 의해 유전자 발현을 조절한다. 일부 구현예에서, 표적 핵산은 GHR이다. 특정 구현예에서, 표적화된 GHR의 분해는 본 발명의 조성물과 함께 형성되는 활성화된 RISC 복합체에 의해 촉진된다.
여러 구현예는 이중가닥의 조성물에 관한 것이고, 여기서, 가닥 중 하나는 예를 들어, 반대 가닥의 RISC(또는 절단) 복합체로의 우선적 로딩에 영향을 주는데 유용하다. 상기 조성물은 선택된 핵산 분자를 표적화하고 하나 이상의 유전자의 발현을 조절하기 위해 유용하다. 일부 구현예에서, 본 발명의 조성물은 표적 RNA 부분에 하이브리드화하여 상기 표적 RNA의 정상 기능을 상실시킨다.
특정 구현예는 이중가닥의 조성물에 관한 것이고, 여기서, 양 가닥은 헤미머 모티프, 완전히 변형된 모티프, 위치적으로 변형된 모티프 또는 교호 모티프를 포함한다. 본 발명의 조성물의 각각의 가닥을 변형시켜 예를 들어, siRNA 경로에서 특정 역할을 완수할 수 있다. 각각 가닥에 상이한 모티프 또는 각각의 가닥에서 상이한 화학적 변형을 갖는 동일한 모티프의 사용은 센스 가닥의 혼입을 억제하면서 RISC 복합체에 대해 안티센스 가닥을 표적화할 수 있게 한다. 상기 모델내에서, 각각의 가닥은 독립적으로 변형시켜 이것이 이의 특정 역할을 위해 증진될 수 있도록 한다. 상기 안티센스 가닥은 5' 말단에서 변형시켜 RISC의 하나의 영역에서 이의 역할을 증진시킬 수 있고 3' 말단은 상이하게 변형시켜 RISC의 상이한 영역에서 이의 역할을 증진시킬 수 있다.
이중가닥 올리고뉴클레오타이드 분자는 자가-상보성 센스 및 안티센스 영역을 포함하는 이중가닥 폴리뉴클레오타이드 분자일 수 있고 여기서, 상기 안티센스 영역은 이의 표적 핵산 분자 또는 이의 부분에서 뉴클레오타이드 서열에 상보적인 뉴클레오타이드 서열을 포함하고 상기 센스 영역은 표적 핵산 서열 또는 이의 부분에 상응하는 뉴클레오타이드 서열을 갖는다. 이중나선 올리고뉴클레오타이드 분자는 2개의 별도의 올리고뉴클레오타이드로부터 어셈블리될 수 있고, 여기서, 하나의 가닥은 센스 가닥이고 다른 가닥은 안티센스 가닥이며, 여기서, 상기 안티센스 및 센스 가닥은 자가-상보적이고(즉, 각각의 가닥은 다른 가닥에 뉴클레오타이드 서열에 상보적인 뉴클레오타이드 서열을 포함하고; 예를 들어, 여기서, 안티센스 가닥 및 센스 가닥은 이중나선 또는 이중가닥 구조를 형성하고, 예를 들어, 여기서, 이중가닥 영역은 약 15 내지 약 30개, 예를 들어, 약 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29 또는 30개 염기쌍이고; 안티센스 가닥은 표적 핵산 분자 또는 이의 부분에서 뉴클레오타이드 서열에 상보적인 뉴클레오타이드 서열을 포함하고 센스 가닥은 표적 핵산 서열 또는 이의 부분에 상응하는 뉴클레오타이드 서열을 포함한다(예를 들어, 이중나선 올리고뉴클레오타이드 분자의 약 15 내지 약 25개 이상의 뉴클레오타이드는 표적 핵산 또는 이의 부분에 상보적이다). 대안적으로, 이중가닥 올리고뉴클레오타이드는 단일 올리고뉴클레오타이드로부터 어셈블리되고, 여기서, siRNA의 자가-상보성 센스 및 안티센스 영역은 핵산 기반 또는 비-핵산 기반 링커(들)에 의해 연결된다.
이중가닥의 올리고뉴클레오타이드는 자가-상보성 센스 및 안티센스 영역을 갖는, 이중나선, 비대칭 이중나선, 헤어핀 또는 비대칭 헤어핀 2차 구조를 갖는 폴리뉴클레오타이드일 수 있고, 여기서, 상기 안티센스 영역은 별도의 표적 핵산 분자 또는 이의 부분에서 뉴클레오타이드 서열에 상보적인 뉴클레오타이드 서열을 포함하고, 상기 센스 영역은 표적 핵산 서열 또는 이의 부분에 상응하는 뉴클레오타이드 서열을 갖는다. 이중가닥의 올리고뉴클레오타이드는 2개 이상의 루프 구조 및 자가 상보성 센스 및 안티센스 영역을 포함하는 스템을 갖는 환형 단일가닥 폴리뉴클레오타이드일 수 있고, 여기서, 상기 안티센스 영역은 표적 핵산 분자 또는 이의 부분에서 뉴클레오타이드 서열에 상보적인 뉴클레오타이드 서열을 포함하고 상기 센스 영역은 표적 핵산 서열 또는 이의 부분에 상응하는 뉴클레오타이드 서열을 갖고, 여기서, 환형 폴리뉴클레오타이드는 RNAi를 매개할 수 있는 활성 siRNA 분자를 생성하기 위해 생체내 또는 시험관내 가공될 수 있다.
특정 구현예에서, 이중가닥 올리고뉴클레오타이드는 별도의 센스 및 안티센스 서열 또는 영역을 포함하고, 상기 센스 및 안티센스 영역은 당업계에 공지된 바와 같이 뉴클레오타이드 또는 비-뉴클레오타이드 링커 분자에 의해 공유적으로 연결되거나 대안적으로 이온 상호작용, 수소 결합, 반데르 발스 상호작용, 소수성 상호작용 및/또는 스택킹 상호작용에 의해 비공유적으로 연결된다. 특정 구현예에서, 이중가닥 올리고뉴클레오타이드는 표적 유전자의 뉴클레오타이드 서열에 상보적인 뉴클레오타이드 서열을 포함한다. 또 다른 구현예에서, 이중가닥 올리고뉴클레오타이드는 표적 유전자의 발현을 억제시키는 방식으로 표적 유전자의 뉴클레오타이드 서열과 상호작용한다.
본원에 사용된 바와 같은, 이중가닥 올리고뉴클레오타이드는 RNA만을 함유하는 상기 분자에 제한될 필요는 없지만 화학적으로 변형된 뉴클레오타이드 및 비-뉴클레오타이드를 추가로 포함한다. 특정 구현예에서, 짧은 간섭 핵산 분자는 2'-하이드록시 (2'-OH) 함유 뉴클레오타이드가 없다. 특정 구현예에서, 짧은 간섭 핵산은 임의로 임의의 리보뉴클레오타이드(예를 들어, 2'-OH 그룹을 갖는 뉴클레오타이드)를 포함하지 않는다. 그러나, RNAi를 지지하기 위한 분자내 리보뉴클레오타이드의 존재를 요구하지 않는 상기 이중가닥 올리고뉴클레오타이드는 부착된 링커 또는 링커들 또는 다른 부작되거나 연합된 그룹, 잔기들 또는 2'-OH 그룹을 갖는 하나 이상의 뉴클레오타이드를 함유하는 쇄를 가질 수 있다. 임의로, 이중가닥 올리고뉴클레오타이드는 뉴클레오타이드 위치 중 약 5, 10, 20, 30, 40, 또는 50%에서 리보뉴클레오타이드를 포함할 수 있다. 본원에 사용된 바와 같은 용어 siRNA는 서열 특이적 RNAi, 예를 들어, 짧은 간섭 RNA (siRNA), 이중가닥 RNA (dsRNA), 마이크로-RNA (miRNA), 짧은 헤어핀 RNA (shRNA), 짧은 간섭 올리고뉴클레오타이드, 짧은 간섭 핵산, 짧은 간섭 변형된 올리고뉴클레오타이드, 화학적으로 변형된 siRNA, 전사 후 유전자 사일런싱 RNA(ptgsRNA), 및 기타를 매개할 수 있는 핵산 분자를 기재하기 위해 사용되는 다른 용어와 동등한 것으로 의미된다. 추가로, 본원에 사용된 바와 같은 용어 RNAi는 전사후 유전자 사일런싱, 해독 억제 또는 후생유전학과 같은 서열 특이적 RNA 간섭을 기재하기 위해 사용되는 다른 용어와 동등한 것으로 의미된다. 예를 들어, 이중가닥 올리고뉴클레오타이드는 전사후 수준 및 전사전 수준 둘다에서 유전자를 후생유전학적으로 사일런싱하기 위해 사용될 수 있다. 비제한적인 실시예에서, 본 발명의 siRNA 분자에 의한 유전자 발현의 후생유전학적 조절은 유전자 발현을 변화시키기 위해 염색질 구조 또는 메틸화 패턴의 siRNA 매개된 변형으로부터 비롯될 수 있다(문헌참조: 예를 들어, Verdel 등, 2004, Science, 303, 672-676; Pal-Bhadra 등, 2004, Science, 303, 669-672; Allshire, 2002, Science, 297, 1818-1819; Volpe 등, 2002, Science, 297, 1833-1837; Jenuwein, 2002, Science, 297, 2215-2218; 및 Hall 등, 2002, Science, 297, 2232-2237).
본원에 제공된 여러 구현예의 화합물 및 조성물은 예를 들어, "헤어핀" 또는 스템-루프 이중가닥 RNA 이펙터 분자를 포함하는 dsRNA-매개된 유전자 사일런싱 또는 RNAi 기작에 의해 GHR을 표적화할 수 있는 것으로 고려되고, 여기서, 자가-상보성 서열을 갖는 단일 RNA 가닥으로 이중가닥 형태 또는 RNA의 2개의 별도 가닥을 포함하는 이중나선 dsRNA 이펙터 분자를 추정할 수 있다. 다양한 구현예에서, 상기 dsRNA는 전반적으로 리보뉴클레오타이드로 이루어지거나, 예를 들어, 2000년 4월 19일자로 출원된 WO 00/63364 또는 1999년 4월 21일자로 출원된 60/130,377에 의해 기재된 바와 같은 하나 또는 2개의 캡핑된 가닥을 함유한다. 상기 dsRNA 또는 dsRNA 이펙터 분자는 분자의 하나의 절편에서의 뉴클레오타이드가 상기 분자의 또 다른 절편에서 뉴클레오타이드와 염기 쌍을 형성하도록 자가-상보성 영역을 갖는 단일 분자일 수 있다. 다양한 구현예에서, 단일 분자로 이루어진 dsRNA는 전반적으로 리보뉴클레오타이드로 이루어지거나 데옥시리보뉴클레오타이드 영역에 상보적인 리보뉴클레오타이드 영역을 포함한다. 대안적으로, 상기 dsRNA는 서로 상보성 영역을 갖는 2개의 상이한 가닥을 포함할 수 있다.
다양한 구현예에서, 양 가닥은 전반적으로 리보뉴클레오타이드로 이루어지고, 하나의 가닥은 전반적으로 리보뉴클레오타이드로 이루어지고 하나의 가닥은 전반적으로 데옥시리보뉴클레오타이드로 이루어지거나, 하나 또는 양 가닥은 리보뉴클레오타이드와 데옥시리보뉴클레오타이드의 혼합물을 함유한다. 특정 구현예에서, 상보성 영역은 서로에 대해서 및 표적 핵산 서열에 대해서 적어도 70, 80, 90, 95, 98, 또는 100% 상보적이다. 특정 구현예에서, 이중가닥 형태에 존재하는 dsRNA 영역은 적어도 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 50, 75,100, 200, 500, 1000, 2000 또는 5000개 뉴클레오타이드를 포함하거나 모든 뉴클레오타이드를 cDNA로 포함하거나 다른 표적 핵산 서열은 dsRNA로 제공된다. 일부 구현예에서, dsRNA는 단일 가닥 말단과 같은 임의의 단일 가닥 영역을 함유하지 않거나 dsRNA는 헤어핀이다. 다른 구현예에서, dsRNA는 하나 이상의 단일가닥 영역 또는 오버행을 갖는다. 특정 구현예에서, RNA/DNA 하이브리드는 안티센스 가닥 또는 영역인 DNA 가닥 또는 영역(예를 들어,표적 핵산과 적어도 70, 80, 90, 95, 98, 또는 100% 상보성을 갖는다) 및 센스 가닥 또는 영역인 RNA 가닥 또는 영역 (예를 들어, 표적 핵산과 적어도 70, 80, 90, 95, 98, 또는 100%의 동일성을 갖는다), 및 그 반대의 경우를 포함한다.
다양한 구현예에서, RNA/DNA 하이브리드는 본원에 기재된 방법 또는 2000년 4월 19일자로 출원된 WO 00/63364 또는 1999년 4월 21일자로 출원된 60/130,377에 의해 기재된 바와 같은 하나 또는 2개의 캡핑된 가닥을 함유한다. 다른 구현예에서, 시험관내 합성된 DNA 가닥은 DNA 가닥의 세포로의 형질전환 전, 형질전환 후 또는 형질전환과 동시에 생체내 또는 시험관내에서 제조된 RNA 가닥과 복합체화된다. 또 다른 구현예에서, dsRNA는 센스 및 안티센스 영역을 함유하는 단일 환형 핵산이거나, dsRNA는 환형 핵산 및 제2 환형 핵산 또는 선형 핵산을 포함한다(문헌참조: 예를 들어, 2000년 4월 19일자로 출원된 WO 00/63364, 또는 1999년 4월 21일자로 출원된 미국 연속 출원 60/130,377). 예시적인 환형 핵산은 라리아트(lariat) 구조를 포함하고, 여기서, 뉴클레오타이드의 유리된 5' 포스포릴 그룹은 루프 백 양상으로 또 다른 뉴클레오타이드의 2' 하이드록실 그룹에 연결된다.
다른 구현예에서, dsRNA는 하나 이상의 변형된 뉴클레오타이드를 포함하고, 여기서, 당에서 2' 위치는 할로겐(예를 들어, 불소 그룹)을 함유하거나, 상응하는 2' 위치가 수소 또는 하이드록실 그룹을 함유하는 상응하는 dsRNA와 비교하여 시험관내 또는 생체내 dsRNA의 반감기를 증가시키는 알콕시 그룹(예를 들어, 메톡시 그룹)을 함유한다. 또 다른 구현예에서, dsRNA는 천연적으로 존재하는 포스포디에스테르 연결체 이외의 인접한 뉴클레오타이드 사이에 하나 이상의 연결체를 포함한다. 상기 연결체의 예는 포스포르아미드, 포스포로티오에이트 및 포스포로디티오에이트 연결체를 포함한다. dsRNA는 또한 미국 특허 제6,673,661호에 교시된 바와 같은 화학적으로 변형된 핵산 분자일 수 있다. 다른 구현예에서, dsRNA는 예를 들어, 2000년 4월 19일자로 출원된 WO 00/63364 또는 1999년 4월 21일자로 출원된 60/130,377에 의해 기재된 바와 같은 하나 또는 2개의 캡핑된 가닥을 함유한다.
다른 구현예에서, dsRNA는 이의 교시가 본원에 참조로서 인용되는 미국 가출원 60/399,998;및 미국 가출원 60/419,532, 및 PCT/US2003/033466에 기재된 임의의 dsRNA 분자 뿐만 아니라 WO 00/63364에 기재된 임의의 적어도 부분적 dsRNA 분자일 수 있다. 임의의 dsRNA는 본원에 기재된 방법 또는 WO 00/63364에 기재된 것들과 같은 표준 방법을 사용하여 시험관내 또는 생체내에서 발현될 수 있다.
점유
특정 구현예에서, 안티센스 화합물은 RNase H를 통한 절단 또는 표적 핵산을 유도하거나 RISC 경로를 통해 절단 또는 격리를 유도할 것으로 예상되지 않는다. 특정 상기 구현예에서, 안티센스 활성은 점유로부터 비롯될 수 있고, 여기서, 하이브리드화된 안티센스 화합물의 존재는 표적 핵산의 활성을 붕괴시킨다. 특정 상기 구현예에서, 안티센스 화합물은 균일하게 변형되거나 혼합된 변형 및/또는 변형되고 비변형된 뉴클레오사이드를 포함할 수 있다.
표적 핵산, 표적 영역 및 뉴클레오타이드 서열
본원에 제공된 화합물로 표적화할 수 있는 성장 호르몬 수용체(GHR)를 암호화하는 뉴클레오타이드 서열은 제한 없이 다음을 포함한다: GENBANK 승인번호 NM_000163.4 (서열번호 1로서 본원에 언급됨) 뉴클레오타이드 42411001-42714000으로부터 절단된 GENBANK 승인번호 NT_006576.16 (서열번호 2로서 본원에 언급됨) GENBANK 승인번호 X06562.1 (서열번호 3으로서 본원에 언급됨) GENBANK 승인번호 DR006395.1 (서열번호 4로서 본원에 언급됨) GENBANK 승인번호 DB052048.1 (서열번호 5로서 본원에 언급됨) GENBANK 승인번호 AF230800.1 (서열번호 6으로서 본원에 언급됨) GENBANK 승인번호 AA398260.1의 상보체 (서열번호 7로서 본원에 언급됨) GENBANK 승인번호 BC136496.1 (서열번호 8로서 본원에 언급됨) GENBANK 승인번호 NM_001242399.2 (서열번호 9로서 본원에 언급됨) GENBANK 승인번호 NM_001242400.2 (서열번호 10으로서 본원에 언급됨) GENBANK 승인번호 NM_001242401.3 (서열번호 11로서 본원에 언급됨) GENBANK 승인번호 NM_001242402.2 (서열번호 12로서 본원에 언급됨) GENBANK 승인번호 NM_001242403.2 (서열번호 13으로서 본원에 언급됨) GENBANK 승인번호 NM_001242404.2 (서열번호 14로서 본원에 언급됨) GENBANK 승인번호 NM_001242405.2 (서열번호 15로서 본원에 언급됨) GENBANK 승인번호 NM_001242406.2 (서열번호 16으로서 본원에 언급됨) GENBANK 승인번호 NM_001242460.1 (서열번호 17로서 본원에 언급됨) GENBANK 승인번호 NM_001242461.1 (서열번호 18로서 본원에 언급됨) GENBANK 승인번호 NM_001242462.1 (서열번호 19로서 본원에 언급됨) 또는 뉴클레오타이드 4410000-4720000으로부터 절단된 GENBANK 승인번호 NW_001120958.1 2296).
하이브리드화
일부 구현예에서, 하이브리드화는 본원에 기재된 안티센스 화합물과 GHR 핵산 사이에서 일어난다. 하이브리드화의 가장 공통된 기작은 핵산 분자의 상보적 뉴클레오염기 사이에 수소 결합(예를 들어, 왓슨-크릭, 후그스텐 또는 보존된 후그스텐 수소 결합)을 포함한다.
하이브리드화는 다양한 조건하에서 일어날 수 있다. 엄중 조건은 서열 의존성이고 천연 및 하이브리드화될 핵산 분자의 조성에 의해 결정된다.
서열이 표적 핵산에 특이적으로 하이브리드화할 것인지를 결정하는 방법은 당업계에 널리 공지되어 있다. 특정 형태에서, 본원에 제공된 안티센스 화합물은 GHR 핵산과 특이적으로 하이브리드화할 수 있다.
상보성
안티센스 화합물 및 표적 핵산은 목적하는 효과가 일어나도록 상기 안티센스 화합물의 충분한 수의 뉴클레오염기가 표적 핵산의 상응하는 뉴클레오염기와 수소 결합할 수 있는 경우 서로 상보적이다(예를 들어, GHR 핵산과 같은 표적 핵산의 안티센스 억제).
안티센스 화합물과 GHR 핵산 사이의 비-상보적 뉴클레오염기는 상기 안티센스 화합물이 표적 핵산에 특이적으로 하이브리드화할 수 있는 상태로 유지되는 경우 허용될 수 있다. 더욱이, 안티센스 화합물은 간섭 또는 인접 절편이 하이브리드화 반응에 포함되지 않도록 GHR 핵산의 하나 이상의 절편 (예를 들어, 루프 구조, 미스매치 또는 헤어핀 구조)상에 하이브리드화할 수 있다.
특정 구현예에서, 본원에 제공된 안티센스 화합물 또는 이의 특정된 부분은 GHR 핵산, 표적 영역, 표적 절편, 또는 이의 특정 부분에 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, 또는 100% 상보적이거나 적어도 상보적이다. 표적 핵산과 안티센스 화합물의 % 상보성은 통상의 방법을 사용하여 결정될 수 있다.
예를 들어, 상기 안티센스 화합물의 20개 뉴클레오염기 중 18개가 표적 영역에 상보적이고 따라서 특이적으로 하이브리드화하는 안티센스 화합물은 90% 상보성을 나타낸다. 상기 실시예에서, 나머지 비상보성 뉴클레오염기는 상보적 뉴클레오염기와 함께 클러스터되거나 분산될 수 있고 서로 또는 상보성 뉴클레오염기와 연속성일 필요는 없다. 이와 같이, 표적 핵산과의 완전한 상보성의 2개 영역에 의해 플랭킹된 4개의 비상보성 뉴클레오염기를 갖는 길이가 18개 뉴클레오염기인 안티센스 화합물은 표적 핵산과 총 77.8%의 상보성을 갖고 따라서 본 발명의 범위내에 속한다. 표적 핵산 영역과 안티센스 화합물의 % 상보성은 통상적으로 BLAST 프로그램 (기본 국부 정렬 연구 도구) 및 당업계에 공지된 PowerBLAST 프로그램을 사용하여 결정할 수 있다 (문헌참조: Altschul 등, J. Mol . Biol., 1990, 215, 403 410; Zhang; 및 Madden, Genome Res., 1997, 7, 649 656). % 상동성, 서열 동일성 또는 상보성은 스미스 및 워터맨의 알고리듬을 사용하는 디폴트 셋팅을 사용하여 예를 들어, 갭 프로그램 (Wisconsin Sequence Analysis Package, Version 8 for Unix, Genetics Computer Group, University Research Park, Madison Wis.)에 의해 결정할 수 있다(문헌참조: Adv. Appl Math., 1981, 2, 482 489).
특정 구현예에서, 본원에 제공된 안티센스 화합물 또는 이의 특정 부분은 표적 핵산 또는 이의 특정 부분과 완전히 상보성(즉, 100% 상보성)이다. 예를 들어, 안티센스 화합물은 GHR 핵산 또는 표적 영역 또는 표적 절편 또는 이의 표적 서열과 완전히 상보성일 수 있다. 본원에 사용된 바와 같은 "완전히 상보적"은 안티센스 화합물의 각각의 뉴클레오염기가 표적 핵산의 상응하는 뉴클레오염기와 정확하게 염기쌍을 형성할 수 있음을 의미한다. 예를 들어, 20개 뉴클레오염기 안티센스 화합물은 안티센스 화합물과 완전히 상보적인 표적핵산의 상응하는 20개 뉴클레오염기 부분이 존재하는 한, 길이가 400개 뉴클레오염기인 표적 서열과 완전히 상보적이다. 완전히 상보적이라 함은 또한 제1 및/또는 제2 핵산의 특정 부분을 언급하는데 사용될 수 있다. 예를 들어, 30개 뉴클레오염기 안티센스 화합물의 20개 뉴클레오염기 부분은 길이가 400개 뉴클레오염기인 표적 서열과 "완전히 상보적"일 수 있다. 30개 뉴클레오염기 올리고뉴클레오타이드 중 20개 뉴클레오염기 부분은 상기 표적 서열이 상응하는 20개 뉴클레오염기 부분을 갖는 경우(여기서, 각각의 뉴클레오염기는 안티센스 화합물 중 20개 뉴클레오염기 부분과 상보적이다) 표적 서열과 완전히 상보적이다. 동시에, 전체 30개 뉴클레오염기 안티센스 화합물은 상기 안티센스 화합물의 나머지 10개의 뉴클레오염기가 또한 표적 서열과 상보적인지에 따라, 표적 서열과 완전히 상보적이거나 상보적이지 아닐 수 있다.
비-상보적 뉴클레오염기의 위치는 안티센스 화합물의 5' 말단 또는 3' 말단에 존재할 수 있다. 대안적으로, 비-상보적 뉴클레오염기 또는 뉴클레오염기들은 안티센스 화합물의 내부 위치에 존재할 수 있다. 2개 이상의 비-상보적 뉴클레오염기가 존재하는 경우, 이들은 연속성(즉, 연결된) 또는 비-연속성일 수 있다. 하나의 구현예에서, 비-상보성 뉴클레오염기는 갭머 안티센스 올기고뉴클레오타이드의 윙 절편에 위치한다.
특정 구현예에서, 길이가 11, 12, 13, 14, 15, 16, 17, 18, 19, 또는 20개 뉴클레오염기 또는 그 이하인 안티센스 화합물은 GHR 핵산 또는 이의 특정 부분에 비해 4개 이하, 3개 이하, 2개 이하 또는 1개 이하의 상보적 뉴클레오염기(들)을 포함한다.
특정 구현예에서, 길이가 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 또는 30개 뉴클레오염기 또는 그 이하인 안티센스 화합물은 GHR 핵산 또는 이의 특정 부분과 같은 표적 핵산에 비해 6개 이하, 5개 이하, 4개 이하, 3개 이하, 2개 이하 또는 1개 이하의 비-상보성 뉴클레오염기(들)을 포함한다.
제공된 안티센스 화합물은 또한 표적 핵산 부분에 상보적인 것들을 포함한다. 본원에 사용된 바와 같은 "부분"은 표적 핵산의 영역 또는 절편내에 한정된 수의 연속(즉, 연결된) 뉴클레오염기를 언급한다. "부분"은 또한 안티센스 화합물의 한정된 수의 연속 뉴클레오염기를 언급할 수 있다. 특정 구현예에서, 안티센스 화합물은 표적 절편의 적어도 8개의 뉴클레오염기 부분과 상보적이다. 특정 구현예에서, 안티센스 화합물은 표적 절편의 적어도 9개의 뉴클레오염기와 상보적이다. 특정 구현예에서, 안티센스 화합물은 표적 절편의 적어도 10개의 뉴클레오염기와 상보적이다. 특정 구현예에서, 안티센스 화합물은 표적 절편의 적어도 11개의 뉴클레오염기 부분과 상보적이다. 특정 구현예에서, 안티센스 화합물은 표적 절편의 적어도 12개 뉴클레오염기 부분과 상보적이다. 특정 구현예에서, 안티센스 화합물은 표적 절편의 적어도 13개의 뉴클레오염기 부분과 상보적이다. 특정 구현예에서, 안티센스 화합물은 표적 절편의 적어도 14개의 뉴클레오염기 부분과 상보적이다. 특정 구현예에서, 안티센스 화합물은 표적 절편의 적어도 15개 뉴클레오염기 부분과 상보적이다. 표적 절편의 적어도 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20개 이상의 뉴클레오염기 부분, 또는 이들 값의 임의의 2개에 의해 정의된 범위와 상보적인 안티센스 화합물이 또한 고려된다.
동일성
본원에 제공된 안티센스 화합물은 또한 특정 뉴클레오타이드 서열, 서열번호 또는 특이적 Isis 번호에 의해 제공된 화합물 또는 이의 부분과 한정된 % 동일성을 가질 수 있다. 본원에 사용된 바와 같은 안티센스 화합물은 이것이 동일한 뉴클레오염기 쌍 형성 능력을 갖는 경우 본원에 기재된 서열과 동일하다. 예를 들어, 기재된 DNA 서열 중 티미딘 대신 우라실을 함유하는 RNA는 우라실 및 티미딘 둘다가 아데닌과 쌍을 형성하기 때문에 DNA 서열과 동일한 것으로 고려된다. 본원에 제공된 안티센스 화합물과 비교하여 비-동일성 염기를 갖는 화합물 뿐만 아니라 본원에 기재된 단축되고 길어진 버젼의 안티센스 화합물이 또한 고려된다. 비-동일성 염기는 서로 인접하거나 안티센스 화합물 전반에 걸쳐 분산되어 있을 수 있다. 안티센스 화합물의 % 동일성은 이것이 비교되는 서열에 비해 동일한 염기 쌍을 갖는 염기 수에 따라 계산된다.
특정 구현예에서, 안티센스 화합물 또는 이의 부분은 본원에 기재된 안티센스 화합물 또는 서열번호 또는 이의 부분 중 하나 이상과 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99% 또는 100% 동일하거나 적어도 동일하다.
특정 구현예에서, 안티센스 화합물 부분은 표적 핵산의 동일한 길이의 부분과 비교한다. 특정 구현예에서, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 또는 25개 뉴클레오염기 부분은 표적 핵산의 동일한 길이의 부분과 비교한다.
특정 구현예에서, 안티센스 올리고뉴클레오타이드 부분은 표적 핵산의 동일한 길이의 부분과 비교한다. 특정 구현예에서, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 또는 25개 뉴클레오염기 부분은 표적 핵산의 동일한 길이의 부분과 비교한다.
변형
뉴클레오사이드는 염기-당 조합이다. 뉴클레오사이드의 뉴클레오염기(또한 염기로서 공지된) 부분은 통상적으로 헤테로사이클릭 염기 잔기이다. 뉴클레오타이드는 뉴클레오사이드의 당 부분에 공유적으로 연결된 포스페이트 그룹을 추가로 포함하는 뉴클레오사이드이다. 펜토푸라노실 당을 포함하는 상기 뉴클레오사이드에 대해, 상기 포스페이트 그룹은 당의 2', 3' 또는 5' 하이드록실 잔기에 연결될 수 있다. 올리고뉴클레오타이드는 선형 중합 올리고뉴클레오타이드를 형성하기 위해 서로 인접한 뉴클레오사이드의 공유 연결을 통해 형성된다. 올리고뉴클레오타이드 구조내에서, 포스페이트 그룹은 통상적으로 올리고뉴클레오타이드의 뉴클레오사이드 상호 연결체를 형성하는 것으로서 언급된다.
안티센스 화합물에 대한 변형은 뉴클레오사이드 상호 연결체, 당 잔기 또는 뉴클레오사이드에 대한 치환 또는 변화를 포함한다. 변형된 안티센스 화합물은 흔히, 예를 들어, 증진된 세포 흡수, 핵산 표적에 대한 증진된 친화성, 뉴클레아제 존재하에 증가된 안정성 또는 증가된 억제 활성과 같은 목적하는 성질 때문에 고유 형태 보다 바람직하다.
화학적으로 변형된 뉴클레오사이드는 또한 이의 표적 핵산에 대해 단축되거나 절단된 안티센스 올리고뉴클레오타이드의 결합 친화성을 증가시키기 위해 사용될 수 있다. 결과적으로, 비교가능한 결과는 흔히 상기 화학적으로 변형된 뉴클레오사이드를 갖는 보다 단축된 안티센스 화합물과 함께 수득될 수 있다.
변형된 뉴클레오사이드 상호 연결
RNA 및 DNA의 천연적으로 존재하는 뉴클레오사이드 상호 연결체는 3'에서 5'의 포스포디에스테르 연결체이다. 하나 이상의 변형된, 즉 비-천연적으로 존재하는 뉴클레오사이드 상호 연결체를 갖는 안티센스 화합물은 흔히 예를 들어, 증진된 세포 흡수, 표적 핵산에 대해 증진된 친화성 및 뉴클레아제의 존재하에 증가된 안정성과 같은 목적하는 성질때문에 천연적으로 존재하는 뉴클레오사이드 상호 연결체를 갖는 안티센스 화합물에 우선하여 선택된다.
변형된 뉴클레오사이드 상호 연결체를 갖는 올리고뉴클레오타이드는 인 원자를 갖지 않는 뉴클레오사이드 상호 연결체 뿐만 아니라 인 원자를 보유하는 뉴클레오사이드 상호 연결체를 포함한다. 대표적인 인 함유 뉴클레오사이드 상호 연결체는 포스포디에스테르, 포스포트리에스테르, 메틸포스포네이트, 포스포라미데이트 및 포스포로티오에이트를 포함하지만 이에 제한되지 않는다. 인-함유 및 비-인 함유 연결체의 제조 방법은 널리 공지되어 있다.
특정 구현예에서, GHR 핵산에 표적화된 안티센스 화합물은 하나 이상의 변형된 뉴클레오사이드 상호 연결체를 포함한다. 특정 구현예에서, 변형된 뉴클레오사이드 상호 연결체는 포스포로티오에이트 연결체이다. 특정 구현예에서, 안티센스 화합물의 각각의 뉴클레오사이드 상호 연결체는 포스포로티오에이트 뉴클레오사이드 상호 연결체이다.
변형된 당 잔기
안티센스 화합물은 임의로 당 그룹이 변형된 하나 이상의 뉴클레오사이드를 함유할 수 있다. 상기 당 변형된 뉴클레오사이드는 안티센스 화합물에 증진된 뉴클레아제 안정성, 증가된 결합 친화성 또는 일부 다른 이로운 생물학적 성질을 부여할 수 있다. 특정 구현예에서, 뉴클레오사이드는 화학적으로 변형된 리보푸라노스 환 잔기를 포함한다. 화학적으로 변형된 리보푸라노스 환의 예는 제한 없이 치환체 그룹(5' 및 2' 치환체 그룹, 바이사이클릭 핵산(BNA)을 형성하기 위한 비-배종 환 원자의 브릿징, S, N(R), 또는 C(R1)(R2로 리보실 환 산소 원자의 대체를 포함하는)(R, R1 및 R2은 각각 독립적으로 H, C1-C12 알킬 또는 보호 그룹이다)의 첨가 및 이의 조합을 포함한다. 화학적으로 변형된 당의 예는 2'-F-5'-메틸 치환된 뉴클레오사이드(문헌참조: 다른 기재된 5',2'-비스 치환된 뉴클레오사이드에 대해 8/21/08자로 공개된 PCT 국제 출원 WO 2008/101157) 또는 2'-위치에서 추가의 치환과 함께 리보실 환 산소 원자의 S로의 대체 (문헌참조: 2005년 6월 16일자로 공개된 미국 특허 출원 US2005-0130923) 또는 대안적으로 BNA의 5'-치환(문헌참조: 11/22/07자로 공개된 PCT 국제 출원 WO 2007/134181, 여기서 LNA는 예를 들어, 5'-메틸 또는 5'-비닐 그룹으로 치환된다)를 포함한다.
변형된 당 잔기를 갖는 뉴클레오사이드의 예는 제한 없이 5'-비닐, 5'-메틸 (R 또는 S), 4'-S, 2'-F, 2'-OCH3, 2'-OCH2CH3, 2'-OCH2CH2F 및 2'-O(CH2)2OCH3 치환체 그룹을 포함하는 뉴클레오사이드를 포함한다. 2' 위치에서 치환체는 또한 알릴, 아미노, 아지도, 티오, O-알릴, O-C1-C10 알킬, OCF3, OCH2F, O(CH2)2SCH3, O(CH2)2-O-N(Rm)(Rn), O-CH2-C(=O)-N(Rm)(Rn), 및 O-CH2-C(=O)-N(R1)-(CH2)2-N(Rm)(Rn)로부터 선택될 수 있고, 여기서, 각각의 Rl, Rm 및 Rn은 독립적으로 H 또는 치환되거나 비치환된 C1-C10 알킬이다.
본원에 사용된 바와 같은 "바이사이클릭 뉴클레오사이드"는 바이사이클릭 당 잔기를 포함하는 변형된 뉴클레오사이드를 언급한다. 바이사이클릭 뉴클레오사이드의 예는 제한 없이 4'와 2' 리보실 환 원자 사이에 브릿지를 포함하는 뉴클레오사이드를 포함한다. 특정 구현예에서, 본원에 제공된 안티센스 화합물은 4'에서 2' 브릿지를 포함하는 하나 이상의 바이사이클릭 뉴클레오사이드를 포함한다. 상기 4'에서 2' 브릿지된 바이사이클릭 뉴클레오사이드의 예는 하기 화학식의 하나를 포함하지만 이에 제한되지 않는다: 4'-(CH2)-O-2' (LNA); 4'-(CH2)-S-2'; 4'-(CH2)2-O-2' (ENA); 4'-CH(CH3)--O-2' (또한 속박된 에틸 또는 cEt로서 언급됨) 및 4'-C-H(CH2OCH3)--O-2' (및 이의 유사체는 2008년 7월 15일자로 공개된 미국 특허 제7,399,845호를 참조한다); 4'-C(CH3)(CH3)--O-2' (및 이의 유사체는 2009년 1월 8일자로 공개된 국제 출원 WO/2009/006478을 참조한다); 4'-CH2-N(OCH3)-2' (및 이의 유사체는 2008년 12월 11일자로 공개된 국제 출원 WO/2008/150729을 참조한다); 4'-CH2-O-N(CH3)-2' (문헌참조: 2004년 9월 2일자로 공개된 미국 특허원 US2004-0171570); 4'-CH2-N(R)-O-2', 여기서, R은 H, C1-C12 알킬, 또는 보호 그룹 (2008년 9월 23일자로 공개된 미국 특허 제7,427,672호를 참조한다); 4'-CH2-C-(H)(CH3)-2' (문헌참조: Chattopadhyaya 등, J. Org . Chem ., 2009, 74, 118-134); 및 4'-CH2-C-(=CH2)-2' (및 이의 유사체는 2008년 12월 8일자로 공개된 국제 출원 WO 2008/154401을 참조한다).
바이사이클릭 뉴클레오사이드와 관련된 추가의 보고는 또한 공개된 문헌에서 찾을 수 있다(문헌참조: 예를 들어: Singh 등,Chem . Commun ., 1998, 4, 455-456; Koshkin 등, Tetrahedron, 1998, 54, 3607-3630; Wahlestedt 등, Proc . Natl . Acad . Sci . U. S. A., 2000, 97, 5633-5638; Kumar 등, Bioorg . Med . Chem . Lett., 1998, 8, 2219-2222; Singh 등, J. Org . Chem., 1998, 63, 10035-10039; Srivastava 등, J. Am. Chem . Soc., 2007, 129(26) 8362-8379; Elayadi 등, Curr . Opinion Invest. Drugs, 2001, 2, 558-561; Braasch 등, Chem . Biol ., 2001, 8, 1-7; 및 Orum 등, Curr . Opinion Mol. Ther ., 2001, 3, 239-243; 미국 특허 번호 6,268,490; 6,525,191; 6,670,461; 6,770,748; 6,794,499; 7,034,133; 7,053,207; 7,399,845; 7,547,684; 및 7,696,345; 미국 특허 공개 번호 US2008-0039618; US2009-0012281; 미국 특허 일련 번호 60/989,574; 61/026,995; 61/026,998; 61/056,564; 61/086,231; 61/097,787; 및 61/099,844; 공개된 PCT 국제 출원 WO 1994/014226; WO 2004/106356; WO 2005/021570; WO 2007/134181; WO 2008/150729; WO 2008/154401; 및 WO 2009/006478). 전술한 바이사이클릭 뉴클레오사이드 각각은, 예를 들어 α-L-리보푸라노스 및 β-D-리보푸라노스를 비롯하여, 하나 이상의 입체화학적 당 배위를 가지도록 제조될 수 있다(WO 99/14226로서 1999년 3월 25일에 공개된 PCT 국제 출원 PCT/DK98/00393 참조).
특정 구현예에서, BNA 뉴클레오사이드의 바이사이클릭 당 잔기는 펜토푸라노실 당 잔기의 4'와 2' 위치 사이에 적어도 하나의 브릿지를 갖는 화합물을 포함하지만 이에 제한되지 않고, 여기서, 상기 브릿지는 독립적으로 -[C(Ra)(Rb)]n-, -C(Ra)=C(Rb)-, -C(Ra)=N-, -C(=O)-, -C(=NRa)-, -C(=S)-, -O-, -Si(Ra)2-, -S(=O)x-, 및 -N(Ra)-로부터 독립적으로 선택되는 1 또는 2 내지 4개의 연결된 그룹을 포함하고;
여기서:
X는 is 0, 1, 또는 2이고;
n은 1, 2, 3, 또는 4이고;
각각의 Ra 및 Rb는 독립적으로 H, 보호 그룹, 하이드록실, C1-C12 알킬, 치환된 C1-C12 알킬, C2-C12 알케닐, 치환된 C2-C12 알케닐, C2-C12 알키닐, 치환된 C2-C12 알키닐, C5-C20 아릴, 치환된 C5-C20아릴, 헤테로사이클 라디칼, 치환된 헤테로사이클 라디칼, 헤테로아릴, 치환된 헤테로아릴, C5-C7 지환족 라디칼, 치환된 C5-C7 지환족 라디칼, 할로겐, OJ1, NJ1J2, SJ1, N3, COOJ1, 아실 (C(=O)-H), 치환된 아실, CN, 설포닐 (S(=O)2-J1), 또는 설폭실 (S(=O)-J1)이고;
각각 J1 및 J2는 독립적으로 H, C1-C12 알킬, 치환된 C1-C12 알킬, C2-C12 알케닐, 치환된 C2-C12 알케닐, C2-C12 알키닐, 치환된 C2-C12 알키닐, C5-C20 아릴, 치환된 C5-C20 아릴, 아실 (C(=O)-H), 치환된 아실, 헤테로사이클 라디칼, 치환된 헤테로사이클 라디칼, C1-C12 아미노알킬, 치환된 C1-C12 아미노알킬 또는 보호 그룹이다.
특정 구현예에서, 바이사이클릭 당 잔기의 브릿지는 -[C(Ra)(Rb)]n-, -[C(Ra)(Rb)]n-O-, -C(RaRb)-N(R)-O- 또는 -C(RaRb)-O-N(R)-이다. 특정 구현예에서, 상기 브릿지는 4'-CH2-2', 4'-(CH2)2-2', 4'-(CH2)3-2', 4'-CH2-O-2', 4'-(CH2)2-O-2', 4'-CH2-O-N(R)-2' 및 4'-CH2-N(R)-O-2'-이고, 여기서, 각각의 R은 독립적으로 H, 보호 그룹 또는 C1-C12 알킬이다.
특정 구현예에서, 바이사이클릭 뉴클레오사이드는 이성체 배위에 의해 추가로 정의된다. 예를 들어, 4'-2' 메틸렌-옥시 브릿지를 포함하는 뉴클레오사이드는 α-L 배위 또는 β-D 배위로 존재할 수 있다. 이전에, α-L-메틸렌옥시 (4'-CH2-O-2') BNA는 안티센스 활성을 보여주는 안티센스 올리고뉴클레오타이드에 혼입하였다(문헌참조: Frieden 등, Nucleic Acids Research, 2003, 21, 6365-6372).
특정 구현예에서, 바이사이클릭 뉴클레오사이드는 하기된 바와 같이 (A) α-L-메틸렌옥시 (4'-CH2-O-2') BNA, (B) β-D-메틸렌옥시 (4'-CH2-O-2') BNA, (C) 에틸렌옥시 (4'-(CH2)2-O-2') BNA, (D) 아미노옥시 (4'-CH2-O-N(R)-2') BNA, (E) 옥시아미노 (4'-CH2-N(R)-O-2') BNA, 및 (F) 메틸(메틸렌옥시) (4'-CH(CH3)-O-2') BNA, (G) 메틸렌-티오 (4'-CH2-S-2') BNA, (H) 메틸렌-아미노 (4'-CH2-N(R)-2') BNA, (I) 메틸 카보사이클릭(4'-CH2-CH(CH3)-2') BNA, (J) 프로필렌 카보사이클릭 (4'-(CH2)3-2') BNA 및 (K) 비닐 BNA를 포함하지만 이에 제한되지 않는다:
Figure 112016006891241-pct00010
여기서, BX는 염기 잔기이고 R은 독립적으로 H, 보호 그룹, C1-C12 알킬 또는 C1-C12 알콕시이다.
특정 구현예에서, 화학식 I를 갖는 바이사이클릭 뉴클레오사이드가 제공된다:
Figure 112016006891241-pct00011
여기서:
BX는 헤테로사이클릭 염기 잔기이고;
-Qa-Qb-Qc-는 -CH2-N(Rc)-CH2-, -C(=O)-N(Rc)-CH2-, -CH2-O-N(Rc)-, -CH2-N(Rc)-O- 또는 -N(Rc)-O-CH2이고;
Rc은 C1-C12 알킬 또는 아미노 보호 그룹이고;
Ta 및 Tb는 각각 독립적으로 H, 하이드록실 보호 그룹, 접합체 그룹, 반응성 인 그룹, 인 잔기 또는 지지체 배지로의 공유 결합이다.
특정 구현예에서, 화학식 II를 갖는 바이사이클릭 뉴클레오사이드가 제공된다:
Figure 112016006891241-pct00012
여기서:
BX는 헤테로사이클릭 염기 잔기이고;
Ta 및 Tb는 각각 독립적으로 H, 하이드록실 보호 그룹, 접합체 그룹, 반응성 인 그룹, 인 잔기 또는 지지체 배지로의 공유 결합이다.
Za는 C1-C6 알킬, C2-C6 알케닐, C2-C6 알키닐, 치환된 C1-C6 알킬, 치환된 C2-C6 알케닐, 치환된 C2-C6 알키닐, 아실, 치환된 아실, 치환된 아미드, 티올 또는 치환된 티오이다.
하나의 구현예에서, 치환된 그룹 각각은 독립적으로 할로겐, 옥소, 하이드록실, OJc, NJcJd, SJc, N3, OC(=X)Jc, 및 NJeC(=X)NJcJd로부터 독립적으로 선택되는 치환체 그룹으로 단일 또는 다중 치환되고, 여기서, 각각의 Jc, Jd 및 Je는 독립적으로 H, C1-C6 알킬, 또는 치환된 C1-C6 알킬이고, X는 O 또는 NJc이다.
특정 구현예에서, 화학식 III를 갖는 바이사이클릭 뉴클레오사이드가 제공된다:
Figure 112016006891241-pct00013
여기서:
BX는 헤테로사이클릭 염기 잔기이고;
Ta 및 Tb는 각각 독립적으로 H, 하이드록실 보호 그룹, 접합체 그룹, 반응성 인 그룹, 인 잔기 또는 지지체 배지로의 공유 결합이다.
Zb는 C1-C6 알킬, C2-C6 알케닐, C2-C6 알키닐, 치환된 C1-C6 알킬, 치환된 C2-C6 알케닐, 치환된 C2-C6 알키닐 또는 치환된 아실 (C(=O)-)이다.
특정 구현예에서, 화학식 IV를 갖는 바이사이클릭 뉴클레오사이드가 제공된다:
Figure 112016006891241-pct00014
여기서:
BX는 헤테로사이클릭 염기 잔기이고;
Ta 및 Tb는 각각 독립적으로 H, 하이드록실 보호 그룹, 접합체 그룹, 반응성 인 그룹, 인 잔기 또는 지지체 배지로의 공유 결합이다.
Rd 는 C1-C6 알킬, 치환된 C1-C6 알킬, C2-C6 알케닐, 치환된 C2-C6 알케닐, C2-C6 알키닐 또는 치환된 C2-C6 알키닐이고;
각각의 qa, qb, qc 및 qd는 독립적으로 H, 할로겐, C1-C6 알킬, 치환된 C1-C6 알킬, C2-C6 알케닐, 치환된 C2-C6 알케닐, C2-C6 알키닐 또는 치환된 C2-C6 알키닐, C1-C6 알콕실, 치환된 C1-C6 알콕실, 아실, 치환된 아실, C1-C6 아미노알킬 또는 치환된 C1-C6 아미노알킬이다;
특정 구현예에서, 화학식 V를 갖는 바이사이클릭 뉴클레오사이드가 제공된다:
Figure 112016006891241-pct00015
여기서:
BX는 헤테로사이클릭 염기 잔기이고;
Ta 및 Tb는 각각 독립적으로 H, 하이드록실 보호 그룹, 접합체 그룹, 반응성 인 그룹, 인 잔기 또는 지지체 배지로의 공유 결합이다.
qa, qb , qe 및 qf는 각각 독립적으로 수소, 할로겐, C1-C12 알킬, 치환된 C1-C12 알킬, C2-C12 알케닐, 치환된 C2-C12 알케닐, C2-C12 알키닐, 치환된 C2-C12 알키닐, C1-C12 알콕시, 치환된 C1-C12 알콕시, OJj, SJj, SOJj, SO2Jj, NJjJk, N3, CN, C(=O)OJj, C(=O)NJjJk, C(=O)Jj, O-C(=O)-NJjJk, N(H)C(=NH)NJjJk, N(H)C(=O)-NJjJk 또는 N(H)C(=S)NJjJk이거나;
또는 qe와 qf는 함께 =C(qg)(qh)이고;
qg 및 qh는 각각 독립적으로, H, 할로겐, C1-C12 알킬 또는 치환된 C1-C12 알킬이다.
이들의 올리고머화 및 핵산 인지 성질을 갖는 메틸렌옥시 (4'-CH2-O-2') BNA 단량체인 아데닌, 사이토신, 구아닌, 5-메틸-사이토신, 티민 및 우라실의 합성 및 제조는 문헌(참조: Koshkin 등, Tetrahedron, 1998, 54, 3607-3630)에 기재되어 있다. BNA 및 이의 제조는 또한 문헌[참조: WO 98/39352 및 WO 99/14226]에 기재되어 있다.
메틸렌옥시 (4'-CH2-O-2') BNA 및 2'-티오-BNA의 유사체가 또한 제조되었다(문헌참조: Kumar 등,Bioorg . Med . Chem . Lett ., 1998, 8, 2219-2222). 핵산 폴리머라제에 대한 기질로서 올리고데옥시리보뉴클레오타이드 이중나선을 포함하는 속박된 뉴클레오사이드 유사체의 제조는 또한 문헌(참조: Wengel 등, WO 99/14226)에 기재되어 있다. 추가로, 신규한 형태적으로 제한된 고친화성 올리고뉴클레오타이드 유사체인 2'-아미노-BNA의 합성은 문헌(참조: Singh 등,J . Org . Chem ., 1998, 63, 10035-10039)에 기재되어 있다. 추가로, 2'-아미노- 및 2'-메틸아미노-BNA가 제조되었고 상보적 RNA 및 DNA 가닥과의 이들의 이중나선의 열 안정성은 이전에 보고되었다.
특정 구현예에서, 화학식 VI를 갖는 바이사이클릭 뉴클레오사이드가 제공된다:
Figure 112016006891241-pct00016
여기서:
BX는 헤테로사이클릭 염기 잔기이고;
Ta 및 Tb는 각각 독립적으로 H, 하이드록실 보호 그룹, 접합체 그룹, 반응성 인 그룹, 인 잔기 또는 지지체 배지로의 공유 결합이다.
각각의 qi, qj, qk 및 ql는 독립적으로 H, 할로겐, C1-C12 알킬, 치환된 C1-C12 알킬, C2-C12 알케닐, 치환된 C2-C12 알케닐, C2-C12 알키닐, 치환된 C2-C12 알키닐, C1-C12 알콕실, 치환된 C1-C12 알콕실, OJj, SJj, SOJj, SO2Jj, NJjJk, N3, CN, C(=O)OJj, C(=O)NJjJk, C(=O)Jj, O-C(=O)-NJjJk, N(H)C(=NH)NJjJk, N(H)C(=O)-NJjJk orN(H)C(=S)NJjJk이고;
qi 및 qj 또는 ql 및 qk는 함께 =C(qg)(qh)이고, 여기서, qg 및 qh는 각각 독립적으로 H, 할로겐, C1-C12 알킬 또는 치환된 C1-C12 알킬이다.
4'-(CH2)3-2' 브릿지 및 알케닐 유사체 브릿지 4'-CH=CH-CH2-2'를 갖는 하나의 카보사이클릭 바이사이클릭 뉴클레오사이드는 문헌(참조: Freier 등, Nucleic Acids Research, 1997, 25(22), 4429-4443; 및 Albaek 등, J. Org . Chem., 2006, 71, 7731-7740)에 기재되었다. 이들의 올리고머화 및 생화학적 연구와 함께 카보사이클릭 바이사이클릭 뉴클레오사이드의 합성 및 제조는 또한 문헌 (Srivastava 등, J. Am. Chem . Soc ., 2007, 129(26), 8362-8379)에 기재되었다.
본원에 사용된 바와 같은 "4'-2' 바이사이클릭 뉴클레오사이드" 또는 "4'에서 2' 바이사이클릭 뉴클레오사이드"는 당 환의 2' 탄소원자 및 4' 탄소원자를 연결하는 푸라노스 환의 2개 탄소 원자를 연결하는 브릿지를 포함하는 푸라노스 환을 포함하는 바이사이클릭 뉴클레오사이드를 언급한다.
본원에 사용된 바와 같은 "모노사이클릭 뉴클레오사이드"는 바이사이클릭 당 잔기가 아닌 변형된 당 잔기를 포함하는 뉴클레오사이드를 언급한다. 특정 구현예에서, 뉴클레오사이드의 당 잔기 또는 당 잔기 유사체는 임의의 위치에서 변형되거나 치환될 수 있다.
본원에 사용된 바와 같은 "2'-변형된 당"은 2' 위치에서 변형된 푸라노실 당을 의미한다. 특정 구현예에서, 상기 변형은 하기로 선택된 치환체를 포함한다: 할라이드, 치환되고 비치환된 알콕시, 치환되고 비치환된 티오알킬, 치환되고 비치환된 아미노 알킬, 치환되고 비치환된 알킬, 치환되고 비치환된 알킬 및 치환되고 비치환된 알키닐을 포함하지만 이에 제한되지 않는다. 특정 구현예에서, 2' 변형은 하기를 포함하지만 이에 제한되지 않는 치환체로서 선택된다: O[(CH2)nO]mCH3, O(CH2)nNH2, O(CH2)nCH3, O(CH2)nF, O(CH2)nONH2, OCH2C(=O)N(H)CH3, 및 O(CH2)nON[(CH2)nCH3]2(여기서, n 및 m은 1-약 10이다). 다른 2'-치환체 그룹은 또한 하기로부터 선택될 수 있다: C1-C12 알킬, 치환된 알킬, 알케닐, 알키닐, 알크아릴, 아르알킬, O-알크아릴 또는 O-아르알킬, SH, SCH3, OCN, Cl, Br, CN, F, CF3, OCF3, SOCH3, SO2CH3, ONO2, NO2, N3, NH2, 헤테로사이클로알킬, 헤테로사이클로알크아릴, 아미노알킬아미노, 폴리-알킬아미노, 치환된 실릴, RNA 절단 그룹, 리포터 그룹, 인터컬레이터, 약역학적 성질을 개선시키기 위한 그룹, 또는 안티센스 화합물의 약동학적 성질을 개선시키기 위한 그룹 및 유사 성질을 갖는 다른 치환체. 특정 구현예에서, 변형된 뉴클레오사이드는 2'-MOE 측쇄를 포함한다(Baker 등,J . Biol . Chem., 1997, 272, 11944-12000). 상기 2'-MOE 치환은 비변형된 뉴클레오사이드, 및 2'- O-메틸, O-프로필, 및 O-아미노프로필과 같은 다른 변형된 뉴클레오사이드와 비교하여 개선된 결합 친화성을 갖는 것으로서 기재되었다. 2'-MOE 치환체를 갖는 올리고뉴클레오타이드는 또한 생체내 사용을 위해 전망있는 특징을 갖는, 유전자 발현의 안티센스 억제제인 것으로 나타났다(문헌참조: Martin, Helv . Chim . Acta, 1995, 78, 486-504; Altmann 등,Chimia, 1996, 50, 168-176; Altmann 등, Biochem . Soc . Trans., 1996, 24, 630-637; 및 Altmann 등, Nucleosides Nucleotides, 1997, 16, 917-926).
본원에 사용된 바와 같은 "변형된 테트라하이드로피란 뉴클레오사이드" 또는 "변형된 THP 뉴클레오사이드"는 정상의 뉴클레오사이드에서 펜토푸라노실 잔기(당 대용물)에 대해 치환된 6원 테트라하이드로피란 "당"을 갖는 뉴클레오사이드를 의미한다. 변형된 THP 뉴클레오사이드는 헥시톨 핵산 (HNA), 아니톨 핵산 (ANA),(문헌참조: Leumann, Bioorg . Med . Chem ., 2002, 10, 841-854), 만니톨 핵산(MNA) 또는 하기 설명된 바와 같은 테트라하이드로피란 환 시스템을 갖는 플루오로 HNA (F-HNA)로서 문헌에서 언급된 것을 포함하지만 이에 제한되지 않는다:
Figure 112016006891241-pct00017
특정 구현예에서, 화학식 VII를 갖는 당 대용물이 선택된다:
Figure 112016006891241-pct00018
여기서, 화학식 VII의 상기 적어도 하나의 테트라하이드로피란 뉴클레오사이드 유사체의 각각에 대해 독립적으로:
BX는 헤테로사이클릭 염기 잔기이고;
Ta 및 Tb는 각각 독립적으로 테트라하이드로푸란 뉴클레오사이드 유사체를 안티센스 화합물로 ㅇ녀결하는 뉴클레오사이드 상호 연결 그룹이거나 Ta 및 Tb중 하나는 테트라하이드로피란 뉴클레오사이드 유사체를 안티센스 화합물에 연결하는 뉴클레오사이드 상호 연결 그룹이고 Ta 및 Tb의 다른 하나는 H, 하이드록실 보호 그룹, 연결된 접합체 그룹 또는 5' 또는 3'-말단 그룹이고;
q1, q2, q3, q4, q5, q6 및 q7은 각각 독립적으로 H, C1-C6 알킬, 치환된 C1-C6 알킬, C2-C6 알케닐, 치환된 C2-C6 알케닐, C2-C6 알키닐 또는 치환된 C2-C6 알키닐이고; R1 및 R2 각각은 수소, 하이드록실, 할로겐, 치환되거나 비치환된 알콕시, NJ1J2, SJ1, N3, OC(=X)J1, OC(=X)NJ1J2, NJ3C(=X)NJ1J2 및 CN으로부터 선택되고, 여기서, X는 O, S 또는 NJ1이고, 각각의 J1, J2 및 J3는 각각 독립적으로 H 또는 C1-C6 알킬이다.
특정 구현예에서, 화학식 VII의 상기 변형된 THP 뉴클레오사이드가 제공되고, 여기서, q1, q2, q3, q4, q5, q6 및 q7는 각각 H이다. 특정 구현예에서, q1, q2, q3, q4, q5, q6 및 q7 중 적어도 하나는 H가 아니다. 특정 구현예에서, q1, q2, q3, q4, q5, q6 및 q7 중 적어도 하나는 메틸이다. 특정 구현예에서, 화학식 VII의 THP 뉴클레오사이드가 제공되고, 여기서, R1 및 R2 중 하나는 플루오로이다. 특정 구현예에서, R1은 플루오로이고 R2 은 H이고; R1은 메톡시이고 R2은 H이고, R1은 메톡시에톡시이고 R2은 H이다.
특정 구현예에서, 당 대용물은 5개 이상의 원자 및 하나 이상의 헤테로원자를 갖는 환을 포함한다. 예를 들어, 모르폴리노 당 잔기를 포함하는 뉴클레오사이드 및 올리고머성 화합물에서 이의 용도는 보고되었다(문헌참조: 예를 들어: Braasch 등,Biochemistry, 2002, 41, 4503-4510; 및 U.S. Patents 5,698,685; 5,166,315; 5,185,444; 및 5,034,506). 본원에 사용된 바와 같은 용어 "모르폴리노"는 하기식을 갖는 당 대용물을 의미한다:
Figure 112016006891241-pct00019
특정 구현예에서, 모르폴리노는 예를 들어, 상기 모르폴리노 구조로부터 다양한 치환체 그룹을 첨가하거나 변화시킴에 의해 변형될 수 있다. 상기 당 대용물은 본원에서 "변형된 모르폴리노"로 언급된다.
제한 없이, 2'-F-5'-메틸 치환된 뉴클레오사이드 (문헌참조: 다른 기재된 5',2'-비스 치환된 뉴클레오사이드에 대해 8/21/08자로 공개된 PCT 국제출원 WO 2008/101157) 및 리보실 환 산소 원자의 S로의 대체 및 2' 위치에서 추가의 치환(문헌참조: 2005년 6월 16일자로 공개된 미국 특허원 US2005-0130923) 또는 대안적으로 바이사이클릭 핵산의 5'-치-환(문헌참조: 11/22/07자로 공개된 PCT 국제 출원 WO 2007/134181, 여기서 4'-CH2-O-2' 바이사이클릭 뉴클레오사이드는 5' 위치에서 5'-메틸 또는 5'-비닐 그룹으로 추가로 치환된다)과 같은 변형의 조합이 또한 제공된다. 이들의 올리고머화 및 생화학적 연구와 함께 카보사이클릭 바이사이클릭 뉴클레오사이드의 합성 및 제조가 또한 기재되었다(문헌참조:, 예를 들어, Srivastava 등, J. Am. Chem. Soc. 2007, 129(26), 8362-8379).
특정 구현예에서, 안티센스 화합물은 천연에 존재하는 뉴클레오사이드에서 펜토푸라노실 잔기 대신 6원 사이클로헥세닐을 갖는 뉴클레오사이드인 하나 이상의 변형된 사이클로헥세닐 뉴클레오사이드를 포함한다. 변형된 사이클로헥세닐 뉴클레오사이드는 문헌에 기재된 것들을 포함하지만 이에 제한되지 않는다(문헌참조: 예를 들어 commonly owned, 공개된 PCT 출원 WO 2010/036696, published on April 10, 2010, Robeyns 등, J. Am. Chem . Soc ., 2008, 130(6), 1979-1984; Horvath 등, Tetrahedron Letters, 2007, 48, 3621-3623; Nauwelaerts 등, J. Am. Chem . Soc., 2007, 129(30), 9340-9348; Gu 등,, Nucleosides, Nucleotides & Nucleic Acids, 2005, 24(5-7), 993-998; Nauwelaerts 등, Nucleic Acids Research, 2005, 33(8), 2452-2463; Robeyns 등, Acta Crystallographica , Section F: Structural Biology; 및 Crystallization Communications, 2005, F61(6), 585-586; Gu 등, Tetrahedron, 2004, 60(9), 2111-2123; Gu 등, Oligonucleotides, 2003, 13(6), 479-489; Wang 등, J. Org . Chem ., 2003, 68, 4499-4505; Verbeure 등, Nucleic Acids Research, 2001, 29(24), 4941-4947; Wang 등, J. Org . Chem., 2001, 66, 8478-82; Wang 등, Nucleosides, Nucleotides & Nucleic Acids, 2001, 20(4-7), 785-788; Wang 등, J. Am. Chem ., 2000, 122, 8595-8602; 공개된 PCT 출원, WO 06/047842; 및 공개된 PCT 출원 WO 01/049687; 이들 각각의 내용은 이들의 전문이 본원에 참조로서 인용된다). 특정 변형된 사이클로헥세닐 뉴클레오사이드는 화학식 X를 갖는다.
Figure 112016006891241-pct00020
여기서, 독립적으로 화학식 X의 상기 적어도 하나의 사이클로헥세닐 뉴클레오사이드 유사체 각각에 대하여:
BX는 헤테로사이클릭 염기 잔기이고;
T3 및 T4는 각각 독립적으로 사이클로헥세닐 뉴클레오사이드 유사체를 안티센스 화합물로 연결하는 뉴클레오사이드 상호 연결 그룹이거나 T3 및 T4 중 하나는 테트라하이드로피란 뉴클레오사이드 유사체를 안티센스 화합물로 연결하는 뉴클레오사이드 상호 연결 그룹이고 T3 및 T4 중 다른 하나는 H, 하이드록실 보호 그룹, 연결된 접합체 그룹 또는 5'- 또는 3'-말단 그룹이고;
q1, q2, q3, q4, q5, q6, q7, q8 및 q9는 각각 독립적으로 H, C1-C6 알킬, 치환된 C1-C6 알킬, C2-C6 알케닐, 치환된 C2-C6 알케닐, C2-C6 알키닐, 치환된 C2-C6 알키닐 또는 다른 당 치환체 그룹이다.
본원에 사용된 바와 같은 "2'-변형된" 또는 "2'-치환된"은 2' 위치에서 H 또는 OH외의 치환체를 포함하는 당을 포함하는 뉴클레오사이드를 언급한다. 2'-변형된 뉴클레오사이드는 당 환의 2개의 탄소 원자들을 연결하는 브릿지가 2' 탄소 및 당 환의 또 다른 탄소를 연결하는 바이사이클릭 뉴클레오사이드; 알릴, 아미노, 아지도, 티오, O-알릴, O-C1-C10 알킬, -OCF3, O-(CH2)2-O-CH3, 2'-O(CH2)2SCH3, O-(CH2)2-O-N(Rm)(Rn), 또는 O-CH2-C(=O)-N(Rm)(Rn)와 같은 비-브릿지 2' 치환체를 갖는 뉴클레오사이드를 포함하지만 이에 제한되지 않고, 여기서, 각각의 Rm 및 Rn은 독립적으로 H 또는 치환된 또는 비치환된 C1-C10 알킬이다. 2'-변형된 뉴클레오사이드는 예를 들어, 당의 다른 부위 및/또는 뉴클레오염기에서 다른 변형을 추가로 포함할 수 있다.
본원에 사용된 바와 같은 "2'-F"는 당 환의 2'위치에서 플루오로 그룹을 포함하는 당을 포함하는 뉴클레오사이드를 언급한다.
본원에 사용된 바와 같은 "2'-OMe" 또는 "2'-OCH3" 또는 "2'-O-메틸" 각각은 당 환의 2' 위치에서 -OCH3 그룹을 포함하는 당을 포함하는 뉴클레오사이드를 언급한다.
본원에 사용된 바와 같은 "MOE" 또는 "2'-MOE" 또는 "2'-OCH2CH2OCH3" 또는 "2'-O-메톡시에틸" 각각은 당 환의 2' 위치에서 -OCH2CH2OCH3 그룹을 포함하는 당을 포함하는 뉴클레오사이드를 언급한다.
본원에 사용된 바와 같은 "올리고뉴클레오타이드"는 다수의 연결된 뉴클레오사이드를 포함하는 화합물을 언급한다. 특정의 구현예에서, 하나 이상의 다수의 뉴클레오타이드는 변형된다. 특정 구현예에서, 올리고뉴클레오타이드는 하나 이상의 리보뉴클레오사이드(RNA) 및/또는 데옥시리보뉴클레오사이드(DNA)를 포함한다.
많은 다른 바이사이클로 및 트리사이클로 당 대용물 환 시스템은 또한 당업계에 널리 공지되어 있고 안티센스 화합물로 혼입시키기 위해 뉴클레오사이드를 변형시키는데 사용될 수 있다: Leumann, Bioorg . Med . Chem ., 2002, 10, 841-854). 이러한 환 시스템은 활성을 증진시키기 위해 다양한 추가적인 치환을 진행할 수 있다.
변형된 당의 제조를 위한 방법은 당업자에게 널리 공지되어 있다. 상기 변형된 당의 제조를 교시하는 일부 대표적인 미국 특허는 제한없이 다음 미국 문헌을 포함한다: 4,981,957; 5,118,800; 5,319,080; 5,359,044; 5,393,878; 5,446,137; 5,466,786; 5,514,785; 5,519,134; 5,567,811; 5,576,427; 5,591,722; 5,597,909; 5,610,300; 5,627,053; 5,639,873; 5,646,265; 5,670,633; 5,700,920; 5,792,847 및 6,600,032 및 International Application PCT/US-2005/019219, filed June 2, 2005 및 published as WO 2005/121371 on December 22, 2005, 이들 각각은 전문이 본원에 참조로서 인용된다.
변형된 당 잔기를 갖는 뉴클레오타이드에서, 상기 뉴클레오염기 잔기(천연, 변형된 또는 이의 조합)는 적당한 핵산 표적과의 하이브리드화를 위해 유지된다.
특정 구현예에서, 안티센스 화합물은 변형된 당 잔기를 갖는 하나 이상의 뉴클레오사이드를 포함한다. 특정 구현예에서, 상기 변형된 당 잔기는 2'-MOE이다. 특정 구현예에서, 상기 2'-MOE 변형된 뉴클레오사이드는 갭머 모티프로 정렬된다. 특정 구현예에서, 상기 변형된 당 잔기는 (4'-CH(CH3)-O-2') 브릿징 그룹을 갖는 바이사이클릭 뉴클레오사이드이다. 특정 구현예에서, (4'-CH(CH3)-O-2') 변형된 뉴클레오사이드는 갭머 모티프의 윙 전반에 걸쳐 정렬된다.
변형된 뉴클레오염기
뉴클레오염기 (또는 염기) 변형 또는 치환은 여전히 기능적으로 상호 교환가능한 천연에 존재하거나 합성 비변형된 뉴클레오염기로부터 구조적으로 구분될 수 있다. 천연 및 변형된 뉴클레오염기 둘다는 수소 결합에 관여할 수 있다. 상기 뉴클레오염기 변형은 뉴클레아제 안정성, 결합 친화성 또는 일부 다른 이로운 생물학적 성질을 안티센스 화합물에 부여할 수 있다. 변형된 뉴클레오염기는, 예를 들어, 5-메틸사이토신 (5-me-C)과 같은 합성 및 천연 뉴클레오염기를 포함한다. 5-메틸사이토신 치환을 포함하는 특정 뉴클레오염기 치환은 특히 표적 핵산에 대한 안티센스 화합물의 결합 친화성을 증가시키기 위해 유용하다. 예를 들어, 5-메틸사이토신 치환은 0.6-1.2°C에 의해 핵산 이중나선 안정성을 증가시키는 것으로 나타났다(문헌참조: Sanghvi, Y.S., Crooke, S.T.; 및 Lebleu, B., eds., Antisense Research; 및 Applications, CRC Press, Boca Raton, 1993, pp. 276-278).
추가의 변형된 뉴클레오염기는 5-하이드록시메틸 사이토신, 크산틴, 하이포산틴, 2-아미노아데닌, 아데노신 및 구아닌의 6-메틸 및 다른 알킬 유도체, 아데닌 및 구아닌의 2-프로필 및 다른 알킬 유도체, 2-티오우라실, 2-티오티민 및 2-티오사이토신, 5-할로우라실 및 사이토신, 5-프로피닐(-C≡C-CH3) 우라실 및 사이토신 및 피리미딘 염기의 다른 알키닐 유도체, 6-아조 우라실, 사이토신 및 티민, 5-우라실 (슈도우라실), 4-티오우라실, 8-할로, 8-아미노, 8-티올, 8-티오알킬, 8-하이드록실 및 다른 8-치환된 아데닌 및 구아닌, 5-할로 특히 5-브로모, 5-트리플루오로메틸 및 다른 5-치환된 우라실 및 사이토신, 7-메틸구아닌 및 7-메틸아데닌, 2-F-아데닌, 2-아미노-아데닌, 8-아다구아닌 및 8-아자아데닌, 7-데아자구아닌 및 7-데아자아데닌 및 3-데아자구아닌 및 3-데아자아데닌을 포함한다.
헤테로사이클릭 염기 잔기는 또한 퓨린 또는 피리미딘 염기가 다른 헤테로사이클, 예를 들어, 7-데아자-아데닌, 7-데아자구아노신, 2-아미노피리딘 및 2-피리돈으로 대체된 것들을 포함할 수 있다. 안티센스 화합물의 결합 친화성을 증가시키기 위해 특히 유용한 뉴클레오염기는 5-치환된 피리미딘, 6-아자피리미딘 및 2-아미노프로필아데닌, 5-프로피닐우라실 및 5-프로피닐사이토신을 포함하는 N-2, N-6 및 O-6 치환된 퓨린을 포함한다.
특정 구현예에서, GHR 핵산에 표적화된 안티센스 화합물은 하나 이상의 변형된 뉴클레오염기를 포함한다. 특정 구현예에서, GHR 핵산에 표적화된 단축되거나 갭-넓어진 안티센스 올리고뉴클레오타이드는 하나 이상의 변형된 뉴클레오염기를 포함한다. 특정 구현예에서, 상기 변형된 뉴클레오염기는 5-메틸사이토신이다. 특정 구현예에서, 각각의 사이토신은 5-메틸사이토신이다.
접합된 안티센스 화합물
안티센스 화합물은 수득한 안티센스 올리고뉴클레오타이드의 활성, 세포 분포 또는 세포 흡수를 증진시키는 하나 이상의 잔기 또는 접합체에 공유적으로 연결될 수 있다. 전형적인 접합체 그룹은 콜레스테롤 잔기 및 지질 잔기를 포함한다. 추가의 접합체 그룹은 탄수화물, 인지질, 비오틴, 페나진, 폴레이트, 페난트리딘, 안트라퀴논, 아크리딘, 플루오레신, 로다민, 쿠마린 및 염료를 포함한다.
안티센스 화합물은 또한 예를 들어, 뉴클레아제 안정성과 같은 성질을 증진시키기 위해 안티센스 화합물의 한쪽 또는 양쪽 말단에 일반적으로 부착된 하나 이상의 안정화 그룹을 갖도록 변형시킬 수 있다. 캡 구조가 안정화 그룹에 포함된다. 이들 말단 변형은 말단 핵산을 갖는 안티센스 화합물을 엑소뉴클레아제 분해로부터 보호하고 세포내 전달 및/또는 국부화를 도와줄 수 있다. 캡은 5'-말단(5'-캡)에서 또는 3'-말단 (3'-캡)에 존재하거나 양쪽 말단상에 존재할 수 있다. 캡 구조는 당업계에 널리 공지되어 있고 예를 들어, 역위 데옥시 비염기성 캡을 포함한다. 뉴클레아제 안정성을 부여하기 위한 안티센스 화합물의 한쪽 또는 양쪽 말단을 캡핑하기 위해 사용될 수 있는 추가의 3' 및 5'-안정화 그룹은 2003년 1월 16일자로 공개된 WO 03/004602에 기재된 것들을 포함한다.
특정 구현예에서, ssRNA로서 사용하기 위해 특히 적합한 것들을 포함하지만 이에 제한되지 않는 안티센스 화합물은 하나 이상의 접합체 그룹의 부착에 의해 변형된다. 일반적으로, 접합체 그룹은 약동학, 약력학, 안정성, 결합, 흡수, 세포 분포, 세포 흡수, 전하 및 제거를 포함하지만 이에 제한되지 않는 부착된 올리고뉴클레오타이드의 하나 이상의 성질을 변형시킨다. 접합체 그룹은 통상적으로 화학적 분야에 사용되고 올리고뉴클레오타이드와 같은 모 화합물에 직접 연결되거나 임의의 접합체 연결 잔기 또는 접합체 연결 그룹을 통해 연결된다. 접합체 그룹은 제한 없이 인터컬레이터, 리포터 분자, 폴리아민, 폴리아미드, 폴리에틸렌 글리콜, 티오에테르, 폴리에테르, 콜레스테롤, 티오콜레스테롤, 콜산 잔기, 폴레이트, 지질, 인지질, 비오틴, 페나진, 페난트리딘, 안트라퀴논, 아다만탄, 아크리딘, 플루오레신, 로다민, 쿠마린 및 염료를 포함한다. 특정 접합체 그룹은 이전에 기재되었고, 예를 들어: 콜레스테롤 잔기(문헌참조: Letsinger 등, Proc. Natl. Acad. Sci. USA, 1989, 86, 6553-6556), 콜산 (Manoharan 등, Bioorg. Med. Chem. Let., 1994, 4, 1053-1060), 티오에테르, 예를 들면, 헥실-S-트리틸티올 (Manoharan 등, Ann. N.Y. Acad. Sci., 1992, 660, 306-309; Manoharan 등, Bioorg. Med. Chem. Let., 1993, 3, 2765-2770), 티오콜레스테롤 (Oberhauser 등, Nucl. Acids Res., 1992, 20, 533-538), 지방족 사슬, 예를 들면, 도데칸디올 또는 운데실 잔기 (Saison-Behmoaras 등, EMBO J., 1991, 10, 1111-1118; Kabanov 등, FEBS Lett., 1990, 259, 327-330; Svinarchuk 등, Biochimie, 1993, 75, 49-54), 인지질, 예를 들면, 디-헥사데실-rac-글리세롤 또는 트리에틸-암모늄 1,2-디-O-헥사데실-rac-글리세로-3-H 포스포네이트 (Manoharan 등, Tetrahedron Lett., 1995, 36, 3651-3654; Shea 등, Nucl. Acids Res., 1990, 18, 3777-3783), 폴리아민 또는 폴리에틸렌 글리콜 사슬 (Manoharan 등, Nucleosides & Nucleotides, 1995, 14, 969-973), 또는 아다만탄 아세트산 (Manoharan 등, Tetrahedron Lett., 1995, 36, 3651-3654), 팔미틸 모이어티 (Mishra 등, Biochim. Biophys. Acta, 1995, 1264, 229-237), 또는 옥타데실아민 또는 헥실아미노-카보닐-옥시콜레스테롤 잔기 (문헌참조: Crooke 등, J. Pharmacol. EXP Ther., 1996, 277, 923-937)가 있다.
ssRNA를 위해 유용한 것들을 포함하는 추가의 접합체 및 안티센스 화합물내 이들의 대용물에 대해, 예를 들어, 미국 출원 번호 61/583,963를 참조한다.
안티센스 올리고뉴클레오타이드의 시험관내 시험
본원에는 다른 안티센스 화합물을 사용한 치료를 위해 적당히 변형될 수 있는, 안티센스 올리고뉴클레오타이드를 사용하여 세포를 치료하기 위한 방법이 기재되어 있다.
세포는 세포가 배양에서 대략 60-80% 컨플루언시에 도달하는 경우 안티센스 올리고뉴클레오타이드로 처리될 수 있다.
안티센스 올리고뉴클레오타이드를 배양된 세포로 도입하기 위해 통상적으로 사용되는 하나의 시약은 양이온 지질 형질감염 시약 LIPOFECTIN (Invitrogen, Carlsbad, CA)을 포함한다. 안티센스 올리고뉴클레오타이드는 목적하는 안티센스 올리고뉴클레오타이드의 최종 농도 및 100nM 안티센스 올리고뉴클레오타이드 당 2 내지 12 ug/mL 범위일 수 있는 LIPOFECTIN 농도를 성취하기 위해 OPTI-MEM 1 (Invitrogen, Carlsbad, CA) 중에서 LIPOFECTIN과 혼합될 수 있다.
안티센스 올리고뉴클레오타이드를 배양된 세포로 도입하기 위해 사용되는 또 다른 시약은 LIPOFECTAMINE (Invitrogen, Carlsbad, CA)을 포함한다. 안티센스 올리고뉴클레오타이드는 안티센스 올리고뉴클레오타이드의 목적하는 농도 및 100nM 안티센스 올리고뉴클레오타이드 당 2 내지 12 ug/mL 범위일 수 있는 LIPOFECTAMINE 농도를 성취하기 위해 OPTI-MEM 1 감소된 혈청 배지 (Invitrogen, Carlsbad, CA) 중에서 LIPOFECTAMINE과 혼합한다.
안티센스 올리고뉴클레오타이드를 배양된 세포로 도입하기 위해 사용되는 또 다른 기술은 전기천공을 포함한다.
안티센스 올리고뉴클레오타이드를 배양된 세포로 도입하기 위해 사용되는 또 다른 기술은 세포에 의한 올리고뉴클레오타이드의 유리된 흡수를 포함한다.
세포는 통상의 방법에 의해 안티센스 올리고뉴클레오타이드로 처리한다. 세포는 안티센스 올리고뉴클레오타이드 처리한지 16 내지 24시간 후 수거할 수 있고, 이 시점에서 표적 핵산의 RNA 또는 단백질 수준은 당업계에 공지되고 본원에 기재된 방법에 의해 측정한다. 일반적으로, 처리가 다중 반복으로 수행되는 경우, 상기 데이타는 반복 처리의 평균으로서 제공된다.
사용된 안티센스 올리고뉴클레오타이드의 농도는 세포주 마다 다양하다. 특정 세포주에 대한 최적의 안티센스 올리고뉴클레오타이드 농도를 결정하기 위한 방법은 당업계에 널리 공지되어 있다. 안티센스 올리고뉴클레오타이드는 전형적으로 LIPOFECTAMINE으로 형질감염되는 경우 1nM 내지 300nM 범위의 농도로 사용된다. 안티센스 올리고뉴클레오타이드는 전기천공을 사용하여 형질감염되는 경우 625 내지 20,000 nM 범위의 보다 높은 농도로 사용된다.
RNA 분리
RNA 분석은 총 세포 RNA 또는 폴리 (A)+ mRNA에 대해 수행될 수 있다. RNA 분리 방법은 당업계에 널리 공지되어 있다. RNA는 예를 들어, 제조업자의 추천된 프로토콜에 따라 TRIZOL 시약 (Invitrogen, Carlsbad, CA)을 사용하여 당업계에 널리 공지된 방법을 사용하여 제조된다.
특정 징후
본원에 제공된 특정 구현예는 GHR에 표적화된 안티센스 화합물 또는 올리고뉴클레오타이드와 같은 GHR 특이적 억제제를 투여함에 의해 대상체에서 과량의 성장 호르몬과 관련된 질환을 치료하거나, 예방하거나 완화시키기 위한 방법에 관한 것이다. 특정 측면에서, 과량의 성장 호르몬과 관련된 질환은 말단 비대증이다. 특정 측면에서, 과량의 성장 호르몬과 관련된 질환은 거인증이다.
특정 구현예는 GHR에 표적화된 안티센스 화합물 또는 올리고뉴클레오타이드와 같은 GHR 특이적 억제제를 투여함에 의해 대상체에서 말단 비대증을 치료하거나, 예방하거나 완화시키는 방법을 제공한다. 말단 비대증은 과량의 성장 호르몬(GH)과 관련된 질환이다. 말단 비대증 환자의 90% 초과에서, 성장 호르몬의 과생성은 과량의 성장 호르몬을 생성하고 뇌 조직 주변을 압박하는, 선암종으로 불리우는 뇌하수체의 양성 종양에 의해 유발된다. 선암종의 증식은 흔히 말단 비대증을 수반하는 두통 및 가시적 손상을 유발할 수 있다. 일부 경우에, 말단 비대증은 GH를 생성하거나 GH를 제조하도록 뇌하수체를 자극하는 호르몬인 성장 호르몬 방출 호르몬(GHRH)을 생성함에 의해 과량의 GH를 유도하는 췌장, 폐 또는 부신 종양에 의해 유발된다.
말단 비대증은 대부분 통상적으로 중년의 성인에서 영향을 주고 중증 손상, 합병증 병태 및 조숙 사망을 유발할 수 있다. 이의 병리 및 느린 진행 때문에, 말단 비대증은 흔히 얼굴에서의 변화와 같이 외부 특징의 변화가 두각될때까지는 진단되지 않는다. 말단 비대증은 흔히 거인증과 관련된다.
말단 비대증의 특징은 손, 발, 코, 입술 및 귀를 확장시키는 연조직 부기 및 피부의 일반적 두터워짐; 심장 및 신장과 같은 내부 기관의 연조직 부기; 낮은 목소리 및 느리게 말하기를 유발하는 성대 부기; 두개골 확장; 흔히 눈 팽창과 함께 현저한 눈썹 돌출; 현저한 하악 돌출 및 혀 확장; 치아 공백 및 수근관 증후군을 포함한다. 특정 구현예에서, 말단 비대증의 이들 특징 중 어느 하나 또는 이의 조합은 본원에 제공된 GHR에 표적화된 화합물 또는 조성물을 투여함에 의해 치료되거나, 예방되거나 완화될 수 있다.
실시예
비제한적인 기재 및 참조문헌의 인용
본원에 기재된 특정 화합물, 조성물 및 방법이 특정 구현예에 따라 특정하게 기재되었지만, 하기의 실시예는 단지 본원에 기재된 화합물을 설명하기 위해 제공된 것이고 이를 제한하는 것으로 의도되지 않는다. 본원에 인용된 문헌 각각은 이의 전문이 본원에 참조로 인용된다.
실시예 1: MOE 갭머에 의한 Hep3B 세포에서 사람 성장 호르몬 수용체의 안티센스 억제
안티센스 올리고뉴클레오타이드는 성장 호르몬 수용체(GHR) 핵산을 표적화하도록 디자인되고 GHR mRNA에 대한 이들의 시험관내 효과에 대해 시험하였다. 안티센스 올리고뉴클레오타이드를 유사한 배양 조건을 갖는 일련의 실험에서 시험했다. 각각의 실험의 결과는 아래에서 보여진 별개의 표에서 제공된다. 웰당 20,000개의 세포의 밀도에서 Hep3B 세포를 5,000 nM 안티센스 올리고뉴클레오타이드에 의한 전기천공을 사용하여 형질감염시켰다. 대략 24 시간의 처리 기간 후, RNA를 세포로부터 단리하고 GHR mRNA 수준을 정량적 실시간 PCR로 측정했다. 사람 프라이머 프로브 세트 RTS3437_MGB (정배향 서열 CGAGTTCAGTGAGGTGCTCTATGT, 본원에서 서열번호 2297로 지정됨: 역배향 서열 AAGAGCCATGGAAAGTAGAAATCTTC, 본원에서 서열번호 2298로 지정됨: 프로브 서열 TTCCTCAGATGAGCCAATT, 본원에서 서열번호 2299로 지정됨) 을 사용하여 mRNA 수준을 측정하였다. GHR mRNA 수준을 RIBOGREEN®에 의해 측정된 바와 같이 총 RNA 함량에 따라 조정했다. 결과는 미처리된 대조군 세포에 대해, GHR의 억제 퍼센트로서 제공된다.
하기 표에서 새롭게 디자인된 키메라 안티센스 올리고뉴클레오타이드는 5-10-5 MOE 또는 3-10-4 MOE 갭머로서 디자인하였다. 상기 5-10-5 MOE 갭머는 길이가 20개 뉴클레오타이드이고, 여기서, 중앙 갭 절편은 흔히 2'-데옥시뉴클레오사이드로 구성되고 각각 5개의 뉴클레오사이드를 포함하는 5' 방향 및 3' 방향상에서 윙 절편에 의해 플랭킹된다. 상기 3-10-4 MOE 갭머는 길이가 17개 뉴클레오사이드이고, 여기서, 중앙 갭 절편은 10개의 2'-데옥시뉴클레오사이드로 구성되고 각각 3개 및 4개 뉴클레오사이드를 포함하는 5' 방향 및 3' 방향상에서 윙 절편에 의해 플랭된다. 5' 윙 절편에서 각각의 뉴클레오사이드 및 3' 윙 절편에서 각각의 뉴클레오사이드는 2'-MOE 변형을 갖는다. 각각의 갭머 전반에 걸친 뉴클레오사이드 상호 연결체는 포스포로티오에이트 (P=S) 연결체이다. 각각의 갭머에 걸친 모든 사이토신 잔기는 5-메틸사이토신이다. "개시 부위"는 갭머가 사람 유전자 서열에서 표적화하는 5' 최외각 뉴클레오사이드를 지적한다. "중지 부위"는 갭머가 표적화된 사람 유전자 서열인 3' 최외각 뉴클레오사이드를 지적한다 하기 표에 열거된 각각의 갭머는 사람 GHR mRNA에 표적화되거나(이는 본원에서 서열번호 1(GENBANK 승인번호 NM_000163.4)로 지정된다) 사람 GHR 게놈 서열에 표적화된다(이는 본원에서 서열번호 2 (GENBANK 승인번호 NT_006576.16, 뉴클레오타이드 42411001-42714000로부터 절단됨)로 지정된다). 'n/a'는 안티센스 올리고뉴클레오타이드가 100% 상보성으로 특정 유전자 서열을 표적화하지 않음을 지적한다. 특정 표에서 표적 유전자에 대한 서열 정렬이 보이지 않는 경우, 상기 표에 제공된 올리고뉴클레오타이드 중 어느 것도 상기 표적 유전자에 100% 상보성으로 정렬하지 않는 것으로 이해된다.
표 1
서열번호: 1 및 2의 5-10-5 MOE 갭머 표적화 엑손 영역에 의한 GHR mRNA의 억제
Figure 112016006891241-pct00021
Figure 112016006891241-pct00022
표 2
서열번호: 1 및 2의 5-10-5 MOE 갭머 표적화 엑손 영역에 의한 GHR mRNA의 억제
Figure 112016006891241-pct00023
표 3
서열번호: 1 및 2의 5-10-5 MOE 갭머 표적화 인트론 및 엑손 영역에 의한 GHR mRNA의 억제
Figure 112016006891241-pct00024
Figure 112016006891241-pct00025
Figure 112016006891241-pct00026
표 4
서열번호: 1 및 2의 5-10-5 MOE 갭머 표적화 인트론 및 엑손 영역에 의한 GHR mRNA의 억제
Figure 112016006891241-pct00027
Figure 112016006891241-pct00028
표 5
서열번호: 1 및 2의 3-10-4 MOE 갭머 표적화 인트론 및 엑손 영역에 의한 GHR mRNA의 억제
Figure 112016006891241-pct00029
Figure 112016006891241-pct00030
표 6
서열번호: 2의 5-10-5 MOE 갭머 표적화 인트론 1에 의한 GHR mRNA의 억제
Figure 112016006891241-pct00031
Figure 112016006891241-pct00032
표 7
서열번호: 2의 5-10-5 MOE 갭머 표적화 인트론 1에 의한 GHR mRNA의 억제
Figure 112016006891241-pct00033
Figure 112016006891241-pct00034
표 8
서열번호: 2의 5-10-5 MOE 갭머 표적화 인트론 1에 의한 GHR mRNA의 억제
Figure 112016006891241-pct00035
Figure 112016006891241-pct00036
표 9
서열번호: 2의 5-10-5 MOE 갭머 표적화 인트론 1에 의한 GHR mRNA의 억제
Figure 112016006891241-pct00037
Figure 112016006891241-pct00038
표 10
서열번호: 2의 5-10-5 MOE 갭머 표적화 인트론 1 및 2에 의한 GHR mRNA의 억제
Figure 112016006891241-pct00039
Figure 112016006891241-pct00040
Figure 112016006891241-pct00041
표 11
서열번호: 2의 5-10-5 MOE 갭머 표적화 인트론 1 및 2에 의한 GHR mRNA의 억제
Figure 112016006891241-pct00042
Figure 112016006891241-pct00043
표 12
서열번호: 2의 5-10-5 MOE 갭머 표적화 인트론 1에 의한 GHR mRNA의 억제
Figure 112016006891241-pct00044
Figure 112016006891241-pct00045
표 13
서열번호: 2의 5-10-5 MOE 갭머 표적화 인트론 2 및 3에 의한 GHR mRNA의 억제
Figure 112016006891241-pct00046
Figure 112016006891241-pct00047
표 14
서열번호: 2의 5-10-5 MOE 갭머 표적화 인트론 2 및 3에 의한 GHR mRNA의 억제
Figure 112016006891241-pct00048
Figure 112016006891241-pct00049
표 15
서열번호: 2의 3-10-4 MOE 갭머 표적화 인트론 2 및 3에 의한 GHR mRNA의 억제
Figure 112016006891241-pct00050
Figure 112016006891241-pct00051
표 16
서열번호: 2의 5-10-5 MOE 갭머 표적화 인트론 1 및 3에 의한 GHR mRNA의 억제
Figure 112016006891241-pct00052
Figure 112016006891241-pct00053
Figure 112016006891241-pct00054
Figure 112016006891241-pct00055
표 17
서열번호: 2의 5-10-5 MOE 갭머 표적화 인트론 3에 의한 GHR mRNA의 억제
Figure 112016006891241-pct00056
Figure 112016006891241-pct00057
표 18
서열번호: 2의 5-10-5 MOE 갭머 표적화 인트론 3-8 및 인트론-엑손 영역에 의한 GHR mRNA의 억제
Figure 112016006891241-pct00058
Figure 112016006891241-pct00059
표 19
서열번호: 2의 5-10-5 MOE 갭머 표적화 인트론 3-8에 의한 GHR mRNA의 억제
Figure 112016006891241-pct00060
Figure 112016006891241-pct00061
실시예 2: MOE 갭머에 의한 Hep3B 세포 중 인간 GHR의 용량-의존 안티센스 억제
GHR mRNA의 유의미한 시험관내 억제를 나타내는 실시예 1로부터의 갭머를 선택하고 Hep3B 세포에서 다양한 용량으로 시험했다. 안티센스 올리고뉴클레오타이드를 유사한 배양 조건을 갖는 일련의 실험에서 시험했다. 각각의 실험의 결과는 아래에서 보여진 별개의 표에서 제공된다. 세포를 웰당 20,000개의 세포 밀도로 플레이팅하고 아래의 표에서 구체화된 바와 같이 0.625 μM, 1.25 μM, 2.50 μM, 5.00 μM 및 10.00 μM 농도의 안티센스 올리고뉴클레오타이드에 의한 전기천공을 사용하여 형질감염시켰다. 대략 16 시간의 처리 기간 후, RNA를 세포로부터 단리하고 GHR mRNA 수준을 정량적 실시간 PCR로 측정했다. 인간 프라미어 프로브 세트 RTS3437_MGB를 사용하여 mRNA 수준을 측정했다. GHR mRNA 수준을 RIBOGREEN®에 의해 측정된 바와 같이 총 RNA 함량에 따라 조정했다. 결과는 미처리된 대조군 세포에 대해, GHR의 억제 퍼센트로서 제공된다.
각각의 올리고뉴클레오타이드의 반최대 억제 농도 (IC50)가 또한 제공된다. GHR mRNA 수준을 안티센스 올리고뉴클레오타이드 처리된 세포에서 용량-의존 방식으로 유의미하게 감소시켰다.
표 20
Figure 112016006891241-pct00062
표 21
Figure 112016006891241-pct00063
표 22
Figure 112016006891241-pct00064
Figure 112016006891241-pct00065
표 23
Figure 112016006891241-pct00066
표 24
Figure 112016006891241-pct00067
Figure 112016006891241-pct00068
표 25
Figure 112016006891241-pct00069
표 26
Figure 112016006891241-pct00070
Figure 112016006891241-pct00071
표 27
Figure 112016006891241-pct00072
표 28
Figure 112016006891241-pct00073
표 29
Figure 112016006891241-pct00074
표 30
Figure 112016006891241-pct00075
표 31
Figure 112016006891241-pct00076
Figure 112016006891241-pct00077
표 32
Figure 112016006891241-pct00078
표 33
Figure 112016006891241-pct00079
Figure 112016006891241-pct00080
실시예 3: MOE 갭머에 의한 Hep3B 세포 중 인간 GHR의 용량-의존 안티센스 억제
GHR mRNA의 유의미한 시험관애 억제를 나타내는 상기 기재된 연구로부터의 갭머를 선택하고; 그리고 Hep3B 세포에서 다양한 용량으로 시험했다. 안티센스 올리고뉴클레오타이드를 유사한 배양 조건을 갖는 일련의 실험에서 시험했다. 각각의 실험의 결과는 아래에서 보여진 별개의 표에서 제공된다. 세포를 웰당 20,000개의 세포 밀도로 플레이팅하고 아래의 표에서 구체화된 바와 같이 0.3125 μM, 0.625 μM, 1.25 μM, 2.50 μM, 5.00 μM 및 10.00 μM 농도의 안티센스 올리고뉴클레오타이드에 의한 전기천공을 사용하여 형질감염시켰다. 대략 16 시간의 처리 기간 후, RNA를 세포로부터 단리하고 GHR mRNA 수준을 정량적 실시간 PCR로 측정했다. 인간 프라미어 프로브 세트 RTS3437_MGB를 사용하여 mRNA 수준을 측정했다. GHR mRNA 수준을 RIBOGREEN®에 의해 측정된 바와 같이 총 RNA 함량에 따라 조정했다. 결과는 미처리된 대조군 세포에 대해, GHR의 억제 퍼센트로서 제공된다.
각각의 올리고뉴클레오타이드의 반최대 억제 농도 (IC50)가 또한 제공된다. GHR mRNA 수준을 안티센스 올리고뉴클레오타이드 처리된 세포에서 용량-의존 방식으로 유의미하게 감소시켰다.
표 34
Figure 112016006891241-pct00081
표 35
Figure 112016006891241-pct00082
표 36
Figure 112016006891241-pct00083
표 37
Figure 112016006891241-pct00084
Figure 112016006891241-pct00085
실시예 4: MOE 갭머에 의한 Hep3B 세포 중 인간 GHR의 용량-의존 안티센스 억제
GHR mRNA의 유의미한 시험관내 억제를 나타내는 상기 기재된 연구로부터의 갭머를 선택하고 Hep3B 세포에 다양한 용량으로 시험했다. 안티센스 올리고뉴클레오타이드를 유사한 배양 조건을 갖는 일련의 실험에서 시험했다. 각각의 실험의 결과는 아래에서 보여진 별개의 표에서 제공된다. 세포를 웰당 20,000개의 세포 밀도로 플레이팅하고 아래의 표에서 구체화된 바와 같이 0.625 μM, 1.25 μM, 2.50 μM, 5.00 μM 및 10.00 μM 농도의 안티센스 올리고뉴클레오타이드에 의한 전기천공을 사용하여 형질감염시켰다. 대략 16 시간의 처리 기간 후, RNA를 세포로부터 단리하고 GHR mRNA 수준을 정량적 실시간 PCR로 측정했다. 인간 프라미어 프로브 세트 RTS3437_MGB를 사용하여 mRNA 수준을 측정했다. GHR mRNA 수준을 RIBOGREEN®에 의해 측정된 바와 같이 총 RNA 함량에 따라 조정했다. 결과는 미처리된 대조군 세포에 대해, GHR의 억제 퍼센트로서 제공된다.
각각의 올리고뉴클레오타이드의 반최대 억제 농도 (IC50)가 또한 제공된다. GHR mRNA 수준을 안티센스 올리고뉴클레오타이드 처리된 세포에서 용량-의존 방식으로 유의미하게 감소시켰다.
표 38
Figure 112016006891241-pct00086
표 39
Figure 112016006891241-pct00087
Figure 112016006891241-pct00088
표 40
Figure 112016006891241-pct00089
표 41
Figure 112016006891241-pct00090
Figure 112016006891241-pct00091
표 42
Figure 112016006891241-pct00092
표 43
Figure 112016006891241-pct00093
Figure 112016006891241-pct00094
표 44
Figure 112016006891241-pct00095
표 45
Figure 112016006891241-pct00096
표 46
Figure 112016006891241-pct00097
실시예 5: MOE 갭머에 의한 Hep3B 세포 중 인간 GHR의 용량-의존 안티센스 억제
GHR mRNA의 유의미한 시험관내 억제를 나타내는 상기 기재된 연구로부터의 갭머를 선택하고 Hep3B 세포에 다양한 용량으로 시험했다. 안티센스 올리고뉴클레오타이드를 유사한 배양 조건을 갖는 일련의 실험에서 시험했다. 각각의 실험의 결과는 아래에서 보여진 별개의 표에서 제공된다. 세포를 웰당 20,000개의 세포 밀도로 플레이팅하고 아래의 표에서 구체화된 바와 같이 0.3125 μM, 0.625 μM, 1.25 μM, 2.50 μM, 5.00 μM 및 10.00 μM 농도의 안티센스 올리고뉴클레오타이드에 의한 전기천공을 사용하여 형질감염시켰다. 대략 16 시간의 처리 기간 후, RNA를 세포로부터 단리하고 GHR mRNA 수준을 정량적 실시간 PCR로 측정했다. 인간 프라미어 프로브 세트 RTS3437_MGB를 사용하여 mRNA 수준을 측정했다. GHR mRNA 수준을 RIBOGREEN®에 의해 측정된 바와 같이 총 RNA 함량에 따라 조정했다. 결과는 미처리된 대조군 세포에 대해, GHR의 억제 퍼센트로서 제공된다.
각각의 올리고뉴클레오타이드의 반최대 억제 농도 (IC50)가 또한 제공된다. GHR mRNA 수준을 안티센스 올리고뉴클레오타이드 처리된 세포에서 용량-의존 방식으로 유의미하게 감소시켰다.
표 47
Figure 112016006891241-pct00098
표 48
Figure 112016006891241-pct00099
표 49
Figure 112016006891241-pct00100
Figure 112016006891241-pct00101
표 50
Figure 112016006891241-pct00102
실시예 6: 데옥시 , MOE 및 cEt 갭머에 의한 Hep3B 세포에서 인간 성장 호르몬 수용체의 안티센스 억제
성장 호르몬 수용체 (GHR) 핵산을 표적으로 하는 부가적 안티센스 올리고뉴클레오타이드를 디자인하고 시험관내 GHR mRNA 에 대한 그것의 효과에 대해 시험했다. 안티센스 올리고뉴클레오타이드를 유사한 배양 조건을 갖는 일련의 실험에서 시험했다. 각각의 실험의 결과는 아래에서 보여진 별개의 표에서 제공된다. 웰당 20,000개의 세포의 밀도에서 Hep3B 세포를 4,500 nM 안티센스 올리고뉴클레오타이드에 의한 전기천공을 사용하여 형질감염시켰다. 대략 24 시간의 처리 기간 후, RNA를 세포로부터 단리하고 GHR mRNA 수준을 정량적 실시간 PCR로 측정했다. 인간 프라미어 프로브 세트 RTS3437_MGB를 사용하여 mRNA 수준을 측정했다. GHR mRNA 수준을 RIBOGREEN®에 의해 측정된 바와 같이 총 RNA 함량에 따라 조정했다. 결과는 미처리된 대조군 세포에 대해, GHR의 억제 퍼센트로서 제공된다.
아래의 표 중 새롭게 디자인된 키메라성 안티센스 올리고뉴클레오타이드를 데옥시, MOE, 및 cEt 갭머로서 디자인했다. 데옥시, MOE 및 cEt 올리고뉴클레오타이드는 그 길이가 16개의 뉴클레오사이드이고, 상기 뉴클레오사이드는 MOE 당 변형, cEt 당 변형, 또는 데옥시 변형을 갖는다. 화학' 칼럼은 각각의 올리고뉴클레오타이드의 당 변형을 기재한다. 'k'는 cEt 당 변형을 나타내고; 'd'는 데옥시리보오스를 나타내고; 그리고 'e'는 MOE 변형을 나타낸다. 각각의 갭머 전반에 걸친 뉴클레오사이드 상호 연결체는 포스포로티오에이트 (P=S) 연결체이다. 각각의 갭머에 걸친 모든 사이토신 잔기는 5-메틸사이토신이다. "개시 부위"는 갭머가 사람 유전자 서열에서 표적화하는 5' 최외각 뉴클레오사이드를 지적한다. "중지 부위"는 갭머가 표적화된 사람 유전자 서열인 3' 최외각 뉴클레오사이드를 지적한다 하기 표에 열거된 각각의 갭머는 사람 GHR mRNA에 표적화되거나(이는 본원에서 서열번호 1(GENBANK 승인번호 NM_000163.4)로 지정된다) 사람 GHR 게놈 서열에 표적화된다(이는 본원에서 서열번호 2 (GENBANK 승인번호 NT_006576.16, 뉴클레오타이드 42411001-42714000로부터 절단됨)로 지정된다). 'n/a'는 안티센스 올리고뉴클레오타이드가 100% 상보성으로 특정 유전자 서열을 표적화하지 않음을 지적한다. 특정 표에서 표적 유전자에 대한 서열 정렬이 보이지 않는 경우, 상기 표에 제공된 올리고뉴클레오타이드 중 어느 것도 상기 표적 유전자에 100% 상보성으로 정렬하지 않는 것으로 이해된다.
표 51
서열번호: 1 및 2의 데옥시, MOE 및 cEt 갭머 표적화 인트론 및 엑손 영역에 의한 GHR mRNA의 억제
Figure 112016006891241-pct00103
Figure 112016006891241-pct00104
실시예 7: 데옥시 , MOE 및 cEt 갭머에 의한 Hep3B 세포에서 인간 성장 호르몬 수용체의 안티센스 억제
성장 호르몬 수용체 (GHR) 핵산을 표적으로 하는 부가적 안티센스 올리고뉴클레오타이드를 디자인하고 시험관내 GHR mRNA 에 대한 그것의 효과에 대해 시험했다. 안티센스 올리고뉴클레오타이드를 유사한 배양 조건을 갖는 일련의 실험에서 시험했다. 각각의 실험의 결과는 아래에서 보여진 별개의 표에서 제공된다. 웰당 20,000개의 세포의 밀도에서 Hep3B 세포를 4,500 nM 안티센스 올리고뉴클레오타이드에 의한 전기천공을 사용하여 형질감염시켰다. 대략 24 시간의 처리 기간 후, RNA를 세포로부터 단리하고 GHR mRNA 수준을 정량적 실시간 PCR로 측정했다. 인간 프라미어 프로브 세트 RTS3437_MGB를 사용하여 mRNA 수준을 측정했다. GHR mRNA 수준을 RIBOGREEN®에 의해 측정된 바와 같이 총 RNA 함량에 따라 조정했다. 결과는 미처리된 대조군 세포에 대해, GHR의 억제 퍼센트로서 제공된다.
아래의 표 중 새롭게 디자인된 키메라성 안티센스 올리고뉴클레오타이드를 데옥시, MOE, 및 cEt 갭머로서 디자인했다. 데옥시, MOE 및 cEt 올리고뉴클레오타이드는 그 길이가 16개의 뉴클레오사이드이고, 상기 뉴클레오사이드는 MOE 당 변형, cEt 당 변형, 또는 데옥시 변형을 갖는다. 화학' 칼럼은 각각의 올리고뉴클레오타이드의 당 변형을 기재한다. 'k'는 cEt 당 변형을 나타내고; 'd'는 데옥시리보오스를 나타내고; 그리고 'e'는 MOE 변형을 나타낸다. 각각의 갭머 전반에 걸친 뉴클레오사이드 상호 연결체는 포스포로티오에이트 (P=S) 연결체이다. 각각의 갭머에 걸친 모든 사이토신 잔기는 5-메틸사이토신이다. "개시 부위"는 갭머가 사람 유전자 서열에서 표적화하는 5' 최외각 뉴클레오사이드를 지적한다. "중지 부위"는 갭머가 표적화된 사람 유전자 서열인 3' 최외각 뉴클레오사이드를 지적한다 하기 표에 열거된 각각의 갭머는 사람 GHR mRNA에 표적화되거나(이는 본원에서 서열번호 1(GENBANK 승인번호 NM_000163.4)로 지정된다) 사람 GHR 게놈 서열에 표적화된다(이는 본원에서 서열번호 2 (GENBANK 승인번호 NT_006576.16, 뉴클레오타이드 42411001-42714000로부터 절단됨)로 지정된다). 'n/a'는 안티센스 올리고뉴클레오타이드가 100% 상보성으로 특정 유전자 서열을 표적화하지 않음을 지적한다. 특정 표에서 표적 유전자에 대한 서열 정렬이 보이지 않는 경우, 상기 표에 제공된 올리고뉴클레오타이드 중 어느 것도 상기 표적 유전자에 100% 상보성으로 정렬하지 않는 것으로 이해된다. 표 54의 올리고뉴클레오타이드는 서열번호: 1 또는 2를 표적으로 하지 않지만, 하기의 대신에 변이체 유전자 서열을 표적으로 한다: 서열번호: 4 (GENBANK 수납 번호 DR006395.1) 또는 서열번호: 7 (GENBANK 수납 번호 AA398260.1의 보충물).
표 52
서열번호: 1 및 2의 데옥시, MOE 및 cEt 갭머 표적화 인트론 및 엑손 영역에 의한 GHR mRNA의 억제
Figure 112016006891241-pct00105
Figure 112016006891241-pct00106
표 53
서열번호: 1 및 2의 데옥시, MOE 및 cEt 갭머 표적화 인트론 및 엑손 영역에 의한 GHR mRNA의 억제
Figure 112016006891241-pct00107
Figure 112016006891241-pct00108
표 54
서열번호: 3 및 4의 데옥시, MOE 및 cEt 갭머 표적화에 의한 GHR mRNA의 억제
Figure 112016006891241-pct00109
표 55
서열번호: 2의 데옥시, MOE; 및 cEt 갭머 표적화 인트론 영역에 의한 GHR mRNA의 억제
Figure 112016006891241-pct00110
Figure 112016006891241-pct00111
표 56
서열번호: 2의 데옥시, MOE; 및 cEt 갭머 표적화 인트론 영역에 의한 GHR mRNA의 억제
Figure 112016006891241-pct00112
Figure 112016006891241-pct00113
표 57
서열번호: 2의 데옥시, MOE; 및 cEt 갭머 표적화 인트론 영역에 의한 GHR mRNA의 억제
Figure 112016006891241-pct00114
Figure 112016006891241-pct00115
표 58
서열번호: 2의 데옥시, MOE 및 cEt 갭머 표적화 인트론 1 및 2에 의한 GHR mRNA의 억제
Figure 112016006891241-pct00116
Figure 112016006891241-pct00117
표 59
서열번호: 2의 데옥시, MOE 및 cEt 갭머 표적화 인트론 2 및 3에 의한 GHR mRNA의 억제
Figure 112016006891241-pct00118
Figure 112016006891241-pct00119
표 60
서열번호: 2의 데옥시, MOE 및 cEt 갭머 표적화 인트론 2 및 3에 의한 GHR mRNA의 억제
Figure 112016006891241-pct00120
Figure 112016006891241-pct00121
표 61
서열번호: 1 및 2의 데옥시, MOE 및 cEt 갭머 표적화 인트론 및 엑손 영역에 의한 GHR mRNA의 억제
Figure 112016006891241-pct00122
Figure 112016006891241-pct00123
표 62
서열번호: 1 및 2의 데옥시, MOE 및 cEt 갭머 표적화 인트론 및 엑손 영역에 의한 GHR mRNA의 억제
Figure 112016006891241-pct00124
Figure 112016006891241-pct00125
표 63
서열번호: 2의 데옥시, MOE 및 cEt 갭머 표적화 인트론 2 및 3에 의한 GHR mRNA의 억제
Figure 112016006891241-pct00126
Figure 112016006891241-pct00127
표 64
서열번호: 1 및 2의 데옥시, MOE 및 cEt 갭머 표적화 인트론 및 엑손 영역에 의한 GHR mRNA의 억제
Figure 112016006891241-pct00128
Figure 112016006891241-pct00129
표 65
서열번호: 1 및 2의 데옥시, MOE 및 cEt 갭머 표적화 인트론 및 엑손 영역에 의한 GHR mRNA의 억제
Figure 112016006891241-pct00130
Figure 112016006891241-pct00131
실시예 8: 데옥시 , MOE 및 cEt 갭머에 의한 Hep3B 세포 중 인간 GHR의 용량-의존 안티센스 억제
GHR mRNA의 유의미한 시험관내 억제를 나타내는 상기 기재된 연구로부터의 갭머를 선택하고 Hep3B 세포에 다양한 용량으로 시험했다. 안티센스 올리고뉴클레오타이드를 유사한 배양 조건을 갖는 일련의 실험에서 시험했다. 각각의 실험의 결과는 아래에서 보여진 별개의 표에서 제공된다. 세포를 웰당 20,000개의 세포 밀도로 플레이팅하고 0.625 μM, 1.25 μM, 2.50 μM, 5.00 μM 및 10.00 μM 농도의 안티센스 올리고뉴클레오타이드에 의한 전기천공을 사용하여 형질감염시켰다. 대략 16 시간의 처리 기간 후, RNA를 세포로부터 단리하고 GHR mRNA 수준을 정량적 실시간 PCR로 측정했다. 인간 프라미어 프로브 세트 RTS3437_MGB를 사용하여 mRNA 수준을 측정했다. GHR mRNA 수준을 RIBOGREEN®에 의해 측정된 바와 같이 총 RNA 함량에 따라 조정했다. 결과는 미처리된 대조군 세포에 대해, GHR의 억제 퍼센트로서 제공된다.
각각의 올리고뉴클레오타이드의 반최대 억제 농도 (IC50)가 또한 제공된다. GHR mRNA 수준을 안티센스 올리고뉴클레오타이드 처리된 세포에서 용량-의존 방식으로 유의미하게 감소시켰다.
표 66
Figure 112016006891241-pct00132
표 67
Figure 112016006891241-pct00133
Figure 112016006891241-pct00134
표 68
Figure 112016006891241-pct00135
표 69
Figure 112016006891241-pct00136
Figure 112016006891241-pct00137
표 70
Figure 112016006891241-pct00138
표 71
Figure 112016006891241-pct00139
표 72
Figure 112016006891241-pct00140
표 73
Figure 112016006891241-pct00141
표 74
Figure 112016006891241-pct00142
Figure 112016006891241-pct00143
표 75
Figure 112016006891241-pct00144
표 76
Figure 112016006891241-pct00145
Figure 112016006891241-pct00146
실시예 9: 데옥시 , MOE 및 cEt 갭머에 의한 Hep3B 세포 중 인간 GHR의 용량-의존 안티센스 억제
GHR mRNA의 유의미한 시험관내 억제를 나타내는 상기 기재된 연구로부터의 갭머를 선택하고 Hep3B 세포에 다양한 용량으로 시험했다. 안티센스 올리고뉴클레오타이드를 유사한 배양 조건을 갖는 일련의 실험에서 시험했다. 각각의 실험의 결과는 아래에서 보여진 별개의 표에서 제공된다. 세포를 웰당 20,000개의 세포 밀도로 플레이팅하고 0.04 μM, 0.11 μM, 0.33 μM, 1.00 μM, 및 3.00 μM 농도의 안티센스 올리고뉴클레오타이드에 의한 전기천공을 사용하여 형질감염시켰다. 대략 16 시간의 처리 기간 후, RNA를 세포로부터 단리하고 GHR mRNA 수준을 정량적 실시간 PCR로 측정했다. 인간 프라미어 프로브 세트 RTS3437_MGB를 사용하여 mRNA 수준을 측정했다. GHR mRNA 수준을 RIBOGREEN®에 의해 측정된 바와 같이 총 RNA 함량에 따라 조정했다. 결과는 미처리된 대조군 세포에 대해, GHR의 억제 퍼센트로서 제공된다.
각각의 올리고뉴클레오타이드의 반최대 억제 농도 (IC50)가 또한 제공된다. GHR mRNA 수준을 안티센스 올리고뉴클레오타이드 처리된 세포에서 용량-의존 방식으로 유의미하게 감소시켰다.
표 77
Figure 112016006891241-pct00147
표 78
Figure 112016006891241-pct00148
표 79
Figure 112016006891241-pct00149
표 80
Figure 112016006891241-pct00150
Figure 112016006891241-pct00151
표 81
Figure 112016006891241-pct00152
표 82
Figure 112016006891241-pct00153
Figure 112016006891241-pct00154
표 83
Figure 112016006891241-pct00155
실시예 10: LLC -MK2 세포에서 레수스 원숭이 GHR의 용량-의존 안티센스 억제
GHR mRNA의 유의미한 시험관내 억제를 나타내는 상기 기재의 연구로부터의 갭머를 선택하고 LLC-MK2 세포에서 레수스 GHR mRNA의 효력에 대해 시험했다. 세포를 웰당 20,000개의 세포 밀도로 플레이팅하고 0.12 μM, 0.37 μM, 1.11 μM, 3.33 μM, 및 10.00 μM 농도의 안티센스 올리고뉴클레오타이드에 의한 전기천공을 사용하여 형질감염시켰다. 대략 16 시간의 처리 기간 후, RNA를 세포로부터 단리하고 GHR mRNA 수준을 정량적 실시간 PCR로 측정했다. 프라미어 프로브 세트 RTS3437_MGB를 사용하여 mRNA 수준을 측정했다. GHR mRNA 수준을 RIBOGREEN®에 의해 측정된 바와 같이 총 RNA 함량에 따라 조정했다. 결과는 미처리된 대조군 세포에 대해, GHR의 억제 퍼센트로서 제공된다.
각각의 올리고뉴클레오타이드의 반최대 억제 농도 (IC50)가 또한 제공된다. GHR mRNA 수준을 안티센스 올리고뉴클레오타이드 처리된 세포에서 용량-의존 방식으로 유의미하게 감소시켰다.
표 84
Figure 112016006891241-pct00156
표 85
Figure 112016006891241-pct00157
실시예 11: 사이노몰구스 1차 간세포에서 GHR의 용량-의존 안티센스 억제
GHR mRNA의 유의미한 시험관내 억제를 나타내는 상기 기재의 연구로부터의 갭머를 선택하고 사이노몰구스 원숭이 1차 간세포에서 GHR mRNA에 대한 효능을 시험했다. 세포를 웰당 20,000개의 세포 밀도로 플레이팅하고 0.12 μM, 0.37 μM, 1.11 μM, 3.33 μM, 및 10.00 μM 농도의 안티센스 올리고뉴클레오타이드에 의한 전기천공을 사용하여 형질감염시켰다. 대략 16 시간의 처리 기간 후, RNA를 세포로부터 단리하고 GHR mRNA 수준을 정량적 실시간 PCR로 측정했다. 프라미어 프로브 세트 RTS3437_MGB를 사용하여 mRNA 수준을 측정했다. GHR mRNA 수준을 RIBOGREEN®에 의해 측정된 바와 같이 총 RNA 함량에 따라 조정했다. 결과는 미처리된 대조군 세포에 대해, GHR의 억제 퍼센트로서 제공된다.
각각의 올리고뉴클레오타이드의 반최대 억제 농도 (IC50)가 또한 제공된다. GHR mRNA 수준을 안티센스 올리고뉴클레오타이드 처리된 세포에서 용량-의존 방식으로 유의미하게 감소시켰다.
표 86
Figure 112016006891241-pct00158
표 87
Figure 112016006891241-pct00159
실시예 12: Hep3B 세포에서 GHR의 용량-의존 안티센스 억제
GHR mRNA의 유의미한 시험관내 억제를 나타내는 상기 기재의 연구로부터의 갭머를 선택하고 Hep3B 세포에서 다양한 용량으로 GHR mRNA의 효능에 대해 시험했다. 세포를 웰당 20,000개의 세포 밀도로 플레이팅하고 0.12 μM, 0.37 μM, 1.11 μM, 3.33 μM, 및 10.00 μM 농도의 안티센스 올리고뉴클레오타이드에 의한 전기천공을 사용하여 형질감염시켰다. 대략 16 시간의 처리 기간 후, RNA를 세포로부터 단리하고 GHR mRNA 수준을 정량적 실시간 PCR로 측정했다. 인간 프라미어 프로브 세트 RTS3437_MGB를 사용하여 mRNA 수준을 측정했다. GHR mRNA 수준을 RIBOGREEN®에 의해 측정된 바와 같이 총 RNA 함량에 따라 조정했다. 결과는 미처리된 대조군 세포에 대해, GHR의 억제 퍼센트로서 제공된다.
각각의 올리고뉴클레오타이드의 반최대 억제 농도 (IC50)가 또한 제공된다. GHR mRNA 수준을 안티센스 올리고뉴클레오타이드 처리된 세포에서 용량-의존 방식으로 유의미하게 감소시켰다.
표 88
Figure 112016006891241-pct00160
표 89
Figure 112016006891241-pct00161
실시예 13: 사이노몰구스 1차 간세포에서 GHR의 용량-의존 안티센스 억제
GHR mRNA의 유의미한 시험관내 억제를 나타내는 상기 기재의 연구로부터의 갭머를 선택하고 사이노몰구스 원숭이 1차 간세포에서 다양한 용량으로 시험했다. 세포를 세포당 35,000개의 세포의 밀도로 플레이팅하고 0.04 μM, 0.12 μM, 0.37 μM, 1.11 μM, 3.33 μM, 및 10.00 μM 농도의 안티센스 올리고뉴클레오타이드에 의한 전기천공을 사용하여 형질감염시켰다. 대략 16 시간의 처리 기간 후, RNA를 세포로부터 단리하고 GHR mRNA 수준을 정량적 실시간 PCR로 측정했다. 프라미어 프로브 세트 RTS3437_MGB를 사용하여 mRNA 수준을 측정했다. GHR mRNA 수준을 RIBOGREEN®에 의해 측정된 바와 같이 총 RNA 함량에 따라 조정했다. 결과는 미처리된 대조군 세포에 대해, GHR의 억제 퍼센트로서 제공된다.
각각의 올리고뉴클레오타이드의 반최대 억제 농도 (IC50)가 또한 제공된다. GHR mRNA 수준을 안티센스 올리고뉴클레오타이드 처리된 세포에서 용량-의존 방식으로 유의미하게 감소시켰다.
표 90
Figure 112016006891241-pct00162
Figure 112016006891241-pct00163
실시예 14: Hep3B 세포에서 GHR의 용량-의존 안티센스 억제의 비교 분석
ISIS 532401은 Hep3B 세포에서 다양한 용량으로 시험하여 US 2006/0178325에 기재된 특이적 안티센스 올리고뉴클레오타이드와 비교되었다. 올리고뉴클레오타이드는 상기 출원에서 기재된 연구에서 설명된 효능을 기반으로 선택되었다. 세포를 세포당 20,000개의 세포의 밀도로 플레이팅하고 0.00 μM, 0.33 μM, 1.00 μM, 1.11 μM, 3.00 μM, 및 9.00 μM 농도의 안티센스 올리고뉴클레오타이드에 의한 전기천공을 사용하여 형질감염시켰다. 대략 16 시간의 처리 기간 후, RNA를 세포로부터 단리하고 GHR mRNA 수준을 정량적 실시간 PCR로 측정했다. 인간 프라미어 프로브 세트 RTS3437_MGB를 사용하여 mRNA 수준을 측정했다. GHR mRNA 수준을 RIBOGREEN®에 의해 측정된 바와 같이 총 RNA 함량에 따라 조정했다. 결과는 미처리된 대조군 세포에 대해, GHR의 억제 퍼센트로서 제공된다.
각각의 올리고뉴클레오타이드의 반최대 억제 농도 (IC50)가 또한 제공된다. 이러한 결과는, ISIS 532401가 US 2006/0178325의 많은 효능의 올리고뉴클레오타이드보다 현저히 효능이 많았다는 것을 나타낸다.
표 91
Figure 112016006891241-pct00164
실시예 15: CD1 마우스에서 5-10-5 MOE 갭머 표적화 인간 GHR의 내성
CD1® 마우스 (Charles River, MA)는 안전성 및 효능 시험에 대해 자주 이용된 다목적 마우스 모델이다. 마우스를 상기 기재된 연구로부터 선택된 ISIS 안티센스 올리고뉴클레오타이드로 처리하고 다양한 혈장 화학 마커의 수준에서의 변화에 대해 평가했다.
처리
8 내지 10 주령 수컷 CD1 마우스의 그룹에게 6 주 동안 1 주에 2회 25 mg/kg의 ISIS 올리고뉴클레오타이드 (50 mg/kg/주 용량)을 피하 주사했다. 수컷 CD1 마우스의 하나의 그룹에게 6 주 동안 1 주에 2회 PBS를 피하 주사했다. 마우스를 마지막 투여 48 시간 후에 안락사시키고, 장기 및 혈장을 추가 분석을 위해 수확했다.
혈장 화학 마커
간 및 신장 기능에 대한 ISIS 올리고뉴클레오타이드의 효과를 평가하기 위해, 트랜스아미나제, 빌리루빈, 크레아틴, 및 BUN의 혈장 수준을 자동 임상 화학 분석기를 사용하여 측정했다 (Hitachi Olympus AU400e, Melville, NY). 결과는 표 92에서 제공된다. 안티센스 올리고뉴클레오타이드에 대한 기대된 범위 밖의 간 또는 신장 기능 마커 중 임의의 것의 수준에서 변화를 야기한 ISIS 올리고뉴클레오타이드를 추가 연구에서 제외했다.
표 92
6 주에서 CD1 마우스 혈장 중 혈장 화학 마커
Figure 112016006891241-pct00165
혈액 분석
모든 마우스 그룹으로부터 얻은 혈액을 적혈구용적률 (HCT) 측정 및 분석, 뿐만 아니라 다양한 혈액 세포, 예컨대 WBC, RBC, 및 혈소판, 및 총 헤모글로빈 함량의 측정을 위해 Antech Diagnostics로 보냈다. 결과는 표 93에서 제공된다. 안티센스 올리고뉴클레오타이드에 대한 기대된 범위 밖의 혈액 마커 중 임의의 것의 수준의 변화를 야기한 ISIS 올리고뉴클레오타이드를 추가 연구에서 제외했다.
표 93
6주째에 CD1 마우스 혈장에서 혈액 마커
Figure 112016006891241-pct00166
실시예 16: CD1 마우스에서 5-10-5 MOE 갭머 표적화 인간 GHR의 내성
마우스를 상기 기재된 연구로부터 선택된 ISIS 안티센스 올리고뉴클레오타이드로 처리하고 다양한 혈장 화학 마커의 수준에서의 변화에 대해 평가했다.
처리
8 내지 10 주령 수컷 CD1 마우스의 그룹에게 6 주 동안 1 주에 2회 25 mg/kg의 ISIS 올리고뉴클레오타이드 (50 mg/kg/주 용량)을 피하 주사했다. 수컷 CD1 마우스의 하나의 그룹에게 6 주 동안 1 주에 2회 PBS를 피하 주사했다. 마우스를 마지막 투여 48 시간 후에 안락사시키고, 장기 및 혈장을 추가 분석을 위해 수확했다.
혈장 화학 마커
간 및 신장 기능에 대한 ISIS 올리고뉴클레오타이드의 효과를 평가하기 위해, 트랜스아미나제, 빌리루빈, 크레아틴, 및 BUN의 혈장 수준을 자동 임상 화학 분석기를 사용하여 측정했다 (Hitachi Olympus AU400e, Melville, NY). 결과는 표 94에서 제공된다. 안티센스 올리고뉴클레오타이드에 대한 기대된 범위 밖의 간 또는 신장 기능 마커 중 임의의 것의 수준에서 변화를 야기한 ISIS 올리고뉴클레오타이드를 추가 연구에서 제외했다.
표 94
6 주에서 CD1 마우스 혈장 중 혈장 화학 마커
Figure 112016006891241-pct00167
혈액 분석
모든 마우스 그룹으로부터 얻은 혈액을 적혈구용적률 (HCT) 측정 및 분석, 뿐만 아니라 다양한 혈액 세포, 예컨대 WB), RBC, 및 혈소판, 및 총 헤모글로빈 함량의 측정을 위해 Antech Diagnostics로 보냈다. 결과는 표 95에서 제공된다. 안티센스 올리고뉴클레오타이드에 대한 기대된 범위 밖의 혈액 마커 중 임의의 것의 수준의 변화를 야기한 ISIS 올리고뉴클레오타이드를 추가 연구에서 제외했다.
표 95
6주째에 CD1 마우스 혈장에서 혈액 마커
Figure 112016006891241-pct00168
실시예 17: CD1 마우스에서 3-10-4 MOE 갭머 표적화 인간 GHR의 내성
CD® 마우스를 상기 기재된 연구로부터 선택된 ISIS 안티센스 올리고뉴클레오타이드로 처리하고 다양한 혈장 화학 마커의 수준에서의 변화에 대해 평가했다.
처리
8 내지 10 주령 수컷 CD1 마우스의 그룹에게 6 주 동안 1 주에 2회 25 mg/kg의 ISIS 올리고뉴클레오타이드 (50 mg/kg/주 용량)을 피하 주사했다. 수컷 CD1 마우스의 하나의 그룹에게 6 주 동안 1 주에 2회 PBS를 피하 주사했다. 마우스를 마지막 투여 48 시간 후에 안락사시키고, 장기 및 혈장을 추가 분석을 위해 수확했다.
혈장 화학 마커
간 및 신장 기능에 대한 ISIS 올리고뉴클레오타이드의 효과를 평가하기 위해, 트랜스아미나제, 빌리루빈, 크레아틴, 및 BUN의 혈장 수준을 자동 임상 화학 분석기를 사용하여 측정했다 (Hitachi Olympus AU400e, Melville, NY). 결과는 표 96에서 제공된다. 안티센스 올리고뉴클레오타이드에 대한 기대된 범위 밖의 간 또는 신장 기능 마커 중 임의의 것의 수준에서 변화를 야기한 ISIS 올리고뉴클레오타이드를 추가 연구에서 제외했다.
표 96
6 주에서 CD1 마우스 혈장 중 혈장 화학 마커
Figure 112016006891241-pct00169
혈액 분석
모든 마우스 그룹으로부터 얻은 혈액을 적혈구용적률 (HCT) 측정 및 분석, 뿐만 아니라 다양한 혈액 세포, 예컨대 WBC, RBC, 및 혈소판, 및 총 헤모글로빈 함량의 측정을 위해 Antech Diagnostics로 보냈다. 결과는 표 97에서 제공된다. 안티센스 올리고뉴클레오타이드에 대한 기대된 범위 밖의 혈액 마커 중 임의의 것의 수준의 변화를 야기한 ISIS 올리고뉴클레오타이드를 추가 연구에서 제외했다.
표 97
6주째에 CD1 마우스 혈장에서 혈액 마커
Figure 112016006891241-pct00170
실시예 18: CD1 마우스에서 데옥시 , MOE 및 cEt 갭머 표적화 인간 GHR의 내성
CD1® 마우스를 상기 기재된 연구로부터 선택된 ISIS 안티센스 올리고뉴클레오타이드로 처리하고 다양한 혈장 화학 마커의 수준에서의 변화에 대해 평가했다.
처리
8 내지 10 주령 수컷 CD1 마우스의 그룹에게 6 주 동안 1 주에 2회 25 mg/kg의 ISIS 올리고뉴클레오타이드 (50 mg/kg/주 용량)을 피하 주사했다. 수컷 CD1 마우스의 하나의 그룹에게 6 주 동안 1 주에 2회 PBS를 피하 주사했다. 마우스를 마지막 투여 48 시간 후에 안락사시키고, 장기 및 혈장을 추가 분석을 위해 수확했다.
혈장 화학 마커
간 및 신장 기능에 대한 ISIS 올리고뉴클레오타이드의 효과를 평가하기 위해, 트랜스아미나제, 빌리루빈, 크레아틴, 및 BUN의 혈장 수준을 자동 임상 화학 분석기를 사용하여 측정했다 (Hitachi Olympus AU400e, Melville, NY). 결과는 표 98에서 제공된다. 안티센스 올리고뉴클레오타이드에 대한 기대된 범위 밖의 간 또는 신장 기능 마커 중 임의의 것의 수준에서 변화를 야기한 ISIS 올리고뉴클레오타이드를 추가 연구에서 제외했다.
표 98
6 주에서 CD1 마우스 혈장 중 혈장 화학 마커
Figure 112016006891241-pct00171
혈액 분석
모든 마우스 그룹으로부터 얻은 혈액을 적혈구용적률 (HCT) 측정 및 분석, 뿐만 아니라 다양한 혈액 세포, 예컨대 WBC, RBC, 및 혈소판, 및 총 헤모글로빈 함량의 측정을 위해 Antech Diagnostics로 보냈다. 결과는 표 99에서 제공된다. 안티센스 올리고뉴클레오타이드에 대한 기대된 범위 밖의 혈액 마커 중 임의의 것의 수준의 변화를 야기한 ISIS 올리고뉴클레오타이드를 추가 연구에서 제외했다.
표 99
6주째에 CD1 마우스 혈장에서 혈액 마커
Figure 112016006891241-pct00172
실시예 19: CD1 마우스에서 데옥시 , MOE 및 cEt 갭머 표적화 인간 GHR의 내성
CD1®마우스를 상기 기재된 연구로부터 선택된 ISIS 안티센스 올리고뉴클레오타이드로 처리하고 다양한 혈장 화학 마커의 수준에서의 변화에 대해 평가했다. 3-10-4 MOE 갭머 ISIS 539376을 본 연구에서 또한 포함했다.
처리
8 내지 10 주령 수컷 CD1 마우스의 그룹에게 6 주 동안 1 주에 2회 25 mg/kg의 ISIS 올리고뉴클레오타이드 (50 mg/kg/주 용량)을 피하 주사했다. 수컷 CD1 마우스의 하나의 그룹에게 6 주 동안 1 주에 2회 PBS를 피하 주사했다. 마우스를 마지막 투여 48 시간 후에 안락사시키고, 장기 및 혈장을 추가 분석을 위해 수확했다.
혈장 화학 마커
간 및 신장 기능에 대한 ISIS 올리고뉴클레오타이드의 효과를 평가하기 위해, 트랜스아미나제, 빌리루빈, 크레아틴, 및 BUN의 혈장 수준을 자동 임상 화학 분석기를 사용하여 측정했다 (Hitachi Olympus AU400e, Melville, NY). 결과는 표 100에서 제공된다. 안티센스 올리고뉴클레오타이드에 대한 기대된 범위 밖의 간 또는 신장 기능 마커 중 임의의 것의 수준에서 변화를 야기한 ISIS 올리고뉴클레오타이드를 추가 연구에서 제외했다.
표 100
6 주에서 CD1 마우스 혈장 중 혈장 화학 마커
Figure 112016006891241-pct00173
혈액 분석
모든 마우스 그룹으로부터 얻은 혈액을 적혈구용적률 (HCT) 측정 및 분석, 뿐만 아니라 다양한 혈액 세포, 예컨대 WBC, RBC, 및 총 헤모글로빈 함량의 측정을 위해 Antech Diagnostics로 보냈다. 결과는 표 101에서 제공된다. 안티센스 올리고뉴클레오타이드에 대한 기대된 범위 밖의 혈액 마커 중 임의의 것의 수준의 변화를 야기한 ISIS 올리고뉴클레오타이드를 추가 연구에서 제외했다.
표 101
6주째에 CD1 마우스 혈장에서 혈액 마커
Figure 112016006891241-pct00174
실시예 20: CD1 마우스에서 데옥시 , MOE 및 cEt 갭머 표적화 인간 GHR의 내성
CD1® 마우스를 상기 기재된 연구로부터 선택된 ISIS 안티센스 올리고뉴클레오타이드로 처리하고 다양한 혈장 화학 마커의 수준에서의 변화에 대해 평가했다.
처리
8 내지 10 주령 수컷 CD1 마우스의 그룹에게 6 주 동안 1 주에 2회 25 mg/kg의 ISIS 올리고뉴클레오타이드 (50 mg/kg/주 용량)을 피하 주사했다. 수컷 CD1 마우스의 하나의 그룹에게 6 주 동안 1 주에 2회 PBS를 피하 주사했다. 마우스를 마지막 투여 48 시간 후에 안락사시키고, 장기 및 혈장을 추가 분석을 위해 수확했다.
혈장 화학 마커
간 및 신장 기능에 대한 ISIS 올리고뉴클레오타이드의 효과를 평가하기 위해, 트랜스아미나제, 빌리루빈, 크레아틴, 및 BUN의 혈장 수준을 자동 임상 화학 분석기를 사용하여 측정했다 (Hitachi Olympus AU400e, Melville, NY). 결과는 표 102에서 제공된다. 안티센스 올리고뉴클레오타이드에 대한 기대된 범위 밖의 간 또는 신장 기능 마커 중 임의의 것의 수준에서 변화를 야기한 ISIS 올리고뉴클레오타이드를 추가 연구에서 제외했다.
표 102
6 주에서 CD1 마우스 혈장 중 혈장 화학 마커
Figure 112016006891241-pct00175
혈액 분석
모든 마우스 그룹으로부터 얻은 혈액을 적혈구용적률 (HCT) 측정 및 분석, 뿐만 아니라 다양한 혈액 세포, 예컨대 WBC, RBC, 및 총 헤모글로빈 함량의 측정을 위해 Antech Diagnostics로 보냈다. 결과는 표 103에서 제공된다. 안티센스 올리고뉴클레오타이드에 대한 기대된 범위 밖의 혈액 마커 중 임의의 것의 수준의 변화를 야기한 ISIS 올리고뉴클레오타이드를 추가 연구에서 제외했다.
표 103
6주째에 CD1 마우스 혈장에서 혈액 마커
Figure 112016006891241-pct00176
실시예 21: 스프라그 - 다우리 랫트에서 MOE 갭머 표적화 인간 GHR의 내성
스프라그-다우리 랫트는 안전성 및 효능 평가를 위해 사용된 다목적 모델이다. 랫트를 상기 실시예에서 기재된 연구로부터의 ISIS 안티센스 올리고뉴클레오타이드로 처리하고 다양한 혈장 화학 마커의 수준에서의 변화에 대해 평가했다.
처리
수컷 스프라그-다우리 랫트는 12-시간 밝은/검은 원 상에서 유지되었고 퓨리나 정상 랫트 차우, 다이어타가 5001가 임의로 공급되었다. 4 마리의 스프라그-다우리 랫트 각각의 그룹에게 6 주 동안 1 주에 2회 25 mg/kg의 ISIS 올리고뉴클레오타이드 (100 mg/kg 매주 용량)이 피하 주사되었다. 마지막 투여 48 시간 후에, 랫트를 안락사시키고 장기 및 혈장을 추가 분석을 위해 수확했다.
간 기능
간 기능에 대한 ISIS 올리고뉴클레오타이드의 효과를 평가하기 위해, 트랜스아미나제의 혈장 수준을 자동 임상 화학 분석기를 사용하여 측정했다 (Hitachi Olympus AU400e, Melville, NY). ALT (알라닌 트랜스아미나제) 및 AST (아스파르테이트 트랜스아미나제)의 혈장 수준 을 측정하고 결과는 IU/L으로 표현된 표 104에서 제공된다. 빌리루빈의 혈장 수준은 동일한 임상 화학 분석기를 사용하여 또한 측정되었고 결과는 또한 mg/dL으로 표현된 표 104에서 제공된다. 안티센스 올리고뉴클레오타이드의 기대된 범위 밖의 간 기능의 임의의 마커의 수준의 변화를 야기한 ISIS 올리고뉴클레오타이드를 추가 연구에서 제외했다.
표 104
스프라그-다우리 랫트에서 간 기능 마커
Figure 112016006891241-pct00177
신장 기능
신장 기능에 대한 ISIS 올리고뉴클레오타이드의 효과를 평가하기 위해, 혈액 요소 질소 (BUN) 및 크레아틴의 혈장 수준을 자동 임상 화학 분석기 (Hitachi Olympus AU400e, Melville, NY)을 사용하여 측정했다. 결과는 표 105에서 제공되고, mg/dL으로 표현된다. 안티센스 올리고뉴클레오타이드의 기대된 범위 밖의 신장 기능 마커 중 임의의 것의 수준의 변화를 야기한 ISIS 올리고뉴클레오타이드를 추가 연구에서 제외했다.
표 105
스프라그-다우리 랫트 신장 기능 마커 (mg/dL)
Figure 112016006891241-pct00178
혈액 분석
모든 마우스 그룹으로부터 얻은 혈액을 적혈구용적률 (HCT) 측정 및 분석, 뿐만 아니라 다양한 혈액 세포, 예컨대 WBC, RBC, 및 총 헤모글로빈 함량의 측정을 위해 Antech Diagnostics로 보냈다. 결과는 표 106에서 제공된다. 안티센스 올리고뉴클레오타이드에 대한 기대된 범위 밖의 혈액 마커 중 임의의 것의 수준의 변화를 야기한 ISIS 올리고뉴클레오타이드를 추가 연구에서 제외했다.
표 106
스프라그-다우리 랫트에서 혈액 마커
Figure 112016006891241-pct00179
장기 중량
간, 심장, 비장 및 신장 중량을 연구의 말미에서 측정하고, 그 중량은 표 107에서 제공된다. 안티센스 올리고뉴클레오타이드의 기대된 범위 밖의 장기 중량의 임의의 변화를 야기한 ISIS 올리고뉴클레오타이드를 추가 연구로부터 제외했다.
표 107
장기 중량 (g)
Figure 112016006891241-pct00180
실시예 22: 스프라그 - 다우리 랫트에서 데옥시 , MOE , 및 cEt 갭머 표적화 인간 GHR의 내성
스프라그-다우리 랫트를 상기 실시예에서 기재된 연구로부터의 ISIS 안티센스 올리고뉴클레오타이드로 처리하고 다양한 혈장 화학 마커의 수준에서의 변화에 대해 평가했다.
처리
수컷 스프라그-다우리 랫트는 12-시간 밝은/검은 원 상에서 유지되었고 퓨리나 정상 랫트 차우, 다이어타가 5001가 임의로 공급되었다. 4 마리의 스프라그-다우리 랫트 각각의 그룹에게 6 주 동안 1주에 1회 50 mg/kg의 ISIS 올리고뉴클레오타이드 (50 mg/kg 매주 용량)가 피하 주사되었다. 랫트의 2개의 그룹에게 6 주 동안 1주에 1회 PBS를 피하 주사했다. 마지막 투여 48 시간 후에, 랫트를 안락사시키고 장기 및 혈장을 추가 분석을 위해 수확했다.
간 기능
간 기능에 대한 ISIS 올리고뉴클레오타이드의 효과를 평가하기 위해, 트랜스아미나제의 혈장 수준을 자동 임상 화학 분석기를 사용하여 측정했다 (Hitachi Olympus AU400e, Melville, NY). ALT 및 AST 의 혈장 수준을 측정하고 결과는 IU/L으로 표현된 표 108에서 제공된다. 빌리루빈의 혈장 수준은 동일한 임상 화학 분석기를 사용하여 또한 측정되었고 결과는 mg/dL에서 표현된 표 108에서 또한 제공된다. 안티센스 올리고뉴클레오타이드의 기대된 범위 밖의 간 기능의 임의의 마커의 수준의 변화를 야기한 ISIS 올리고뉴클레오타이드를 추가 연구에서 제외했다.
표 108
스프라그-다우리 랫트에서 간 기능 마커
Figure 112016006891241-pct00181
신장 기능
신장 기능에 대한 ISIS 올리고뉴클레오타이드의 효과를 평가하기 위해, 혈액 요소 질소 (BUN) 및 크레아틴의 혈장 수준을 자동 임상 화학 분석기 (Hitachi Olympus AU400e, Melville, NY)을 사용하여 측정했다. 결과는 표 109에서 제공되고, mg/dL으로 표현된다. 안티센스 올리고뉴클레오타이드의 기대된 범위 밖의 신장 기능 마커 중 임의의 것의 수준의 변화를 야기한 ISIS 올리고뉴클레오타이드를 추가 연구에서 제외했다.
표 109
스프라그-다우리 랫트 신장 기능 마커 (mg/dL)
Figure 112016006891241-pct00182
혈액 분석
모든 마우스 그룹으로부터 얻은 혈액을 적혈구용적률 (HCT) 측정 및 분석, 뿐만 아니라 다양한 혈액 세포, 예컨대 WBC, RBC, 및 총 헤모글로빈 함량의 측정을 위해 Antech Diagnostics로 보냈다. 결과는 표 110에서 제공된다. 안티센스 올리고뉴클레오타이드에 대한 기대된 범위 밖의 혈액 마커 중 임의의 것의 수준의 변화를 야기한 ISIS 올리고뉴클레오타이드를 추가 연구에서 제외했다.
표 110
스프라그-다우리 랫트에서 혈액 마커
Figure 112016006891241-pct00183
장기 중량
간, 심장, 비장 및 신장 중량을 연구의 말미에서 측정하고, 그 중량은 표 111에서 제공된다. 안티센스 올리고뉴클레오타이드의 기대된 범위 밖의 장기 중량의 임의의 변화를 야기한 ISIS 올리고뉴클레오타이드를 추가 연구로부터 제외했다.
표 111
장기 중량 (g)
Figure 112016006891241-pct00184
실시예 23: 사이노몰구스 원숭이에서 ISIS 안티센스 올리고뉴클레오타이드 표적화 인간 GHR의 효과
사이노몰구스 원숭이는 상기 실시예에서 기재된 연구로부터 선택된 ISIS 안티센스 올리고뉴클레오타이드로 치료되었다. 간 및 신장에서 안티센스 올리고뉴클레오타이드 효능 및 내성, 뿐만 아니라 그것의 약동학 프로파일이 평가되었다.
연구가 착수된 때에, 사이노몰구스 원숭이 게놈 서열은 National Center for Biotechnology Information (NCBI) 데이터베이스에서 이용가능하지 않고; 따라서, 사이노몰구스 원숭이 유전자 서열과의 교차반응성이 확인될 수 없었다. 대신에, 사이노몰구스 원숭이에서 사용된 ISIS 안티센스 올리고뉴클레오타이드의 서열은 상동성에 대해 레수스 원숭이 서열과 비교되었다. 레수스 원숭이 서열에 대한 상동성을 갖는 ISIS 올리고뉴클레오타이드가 또한 사이노몰구스 원숭이 서열과 완전히 교차반응하는 것으로 기대된다. 시험된 인간 안티센스 올리고뉴클레오타이드는 레수스 게놈 서열과 교차 반응한다 (뉴클레오타이드 4410000-4720000 로부터 끝이 잘린 GENBANK 수납 번호 NW_001120958.1, 이것은 하기로서 지정됨: 서열번호: 2296). 인간 올리고뉴클레오타이드와 레수스 원숭이 서열 사이에 상보성이 클 수록, 인간 올리고뉴클레오타이드는 레수스 원숭이 서열과 더 많이 교차반응할 수 있을 것 같다. 하기의 서열번호에 대한 각각의 올리고뉴클레오타이드의 개시 및 정지 부위: 2296은 표 112에서 제공된다. "개시 부위"는, 갭머가 레수스 원숭이 유전자 서열에서 표적화되는 5'-최말단 뉴클레오타이드를 나타낸다.
표 112
레수스 GHR 게놈 서열에 대해 상보적인 안티센스 올리고뉴클레오타이드 (서열번호: 2296)
Figure 112016006891241-pct00185
연구 1
연구 전에, 원숭이는, 그 동물이 일반적인 건강 동안에 매일 관찰되는 동안에 격리를 유지했다. 원숭이는 2-4 년령이었고, 체중은 2 내지 4 kg이었다. 5 마리의 무작위로 할당된 수컷 사이노몰구스 원숭이 각각의 9개의 그룹은 원숭이의 캡슐내 영역 및 허벅지 바깥쪽으로 적당한 크기의 스테인레스강 주입 바늘 및 주사기를 사용하여 ISIS 올리고뉴클레오타이드 또는 PBS가 피하 주사되었다. 원숭이에게 첫 번째 주 동안에(1, 4, 및 7 일째) 3회 투여되고, 그 다음 계속해서 12 주 동안 한 주에 1회 40 mg/kg의 ISIS 올리고뉴클레오타이드가 투여되었다. 5 마리의 사이노몰구스 원숭이의 대조군 그룹에게 유사한 방식으로 PBS를 주사하고 그 그룹은 대조군 그룹으로서 쓰인다.
연구 기간 동안에, 원숭이는 병 또는 고통의 징후에 대해 매일 회 관찰되었다. 치료, 상처 또는 병에 의해 순간적 또는 약간의 통증 또는 고통보다 더 많은 경험을 가지고 있는 임의의 동물은 연구 책임자와의 협의 후 통증을 경감시키기 위해 승인된 진통제 또는 제제로 수의 스탭에 의해 치료되었다. 나쁜 건강 또는 가능한 빈사 조건에 있는 임의의 동물은 추가 모니터링 및 가능한 안락사에 대해 확인되었다. 동물의 계획된 안락사는 펜타바르비탈 나트륨의 투여 후에 방혈에 의해 86 일째에 수행되었다. 실시예에서 기재된 프로토콜은 Institutional Animal Care and Use Committee (IACUC)에 의해 승인되었다.
표적 감소
RNA 분석
86 일째에, RNA를 GHR의 mRNA 발현의 측정의 실시간 PCR 분석을 위해 간, 백색 지방질 조직 (WAT) 및 신장으로부터 추출했다. 결과는 RIBOGREEN®으로 정규화된, PBS 대조군에 대한 mRNA의 퍼센트 억제로서 제공된다. 'n.d.'는, 특정 올리고뉴클레오타이드에 대한 데이터가 측정되지 못했다는 것을 나타낸다. 표 113에서 보여진 바와 같이, ISIS 안티센스 올리고뉴클레오타이드에 의한 처리는 PBS 대조군과 비교하여 GHR mRNA의 유의미한 감소를 야기했다. 구체적으로, ISIS 532401에 의한 처리는 모든 조직에서 mRNA 발현의 유의미한 감소를 야기했다.
성장 호르몬-반응성 유전자, 즉 ALS의 발현을 간, 신장 및 지방질 조직에서 또한 측정했다. ISIS 532401에 의한 처리는 GHR 수준과 관련하여 30%까지의 간에서 ALS RNA 발현 감소를 야기했다.± 지방질 조직에서 관찰된 감소는 없었다. 간에서 IGF1의 발현을 또한 측정했다. ISIS 532401에 의한 처리는 GHR 수준과 관련하여 71 ± 10 %까지 간에서 IGF1 RNA 발현 감소를 야기했다.
표 113
PBS 대조군에 대한 사이노몰구스 원숭이 간에서 GHR mRNA의 퍼센트 억제
Figure 112016006891241-pct00186
단백질 분석
대략 1 mL의 혈액을 85 일째에 모든 이용가능한 동물로부터 수집하고 EDTA의 칼륨 염을 함유하는 혈관에 두었다. 혈관을 (3000 rpm 10 분 동안 실온에서) 원심분리하여 혈장을 얻었다. IGF-1 및 GH의 혈장 수준을 상기 혈장에서 측정했다. 결과는 표 114에서 제공된다. 이러한 결과는, ISIS 올리고뉴클레오타이드에 의한 처리가 감소된 IGF-1 단백질 수준을 야기했다는 것을 나타낸다.
ISIS 532401에 의한 처리 후의 IGF1의 혈장 수준은 표 115에서 또한 제공되고 7 일째 및 85 일째에 IGF1 수준의 감소에서 GHR의 안티센스 억제의 효과를 설명한다.
표 114
사이노몰구스 원숭이에서 혈장 단백질 수준
Figure 112016006891241-pct00187
표 115
사이노몰구스 원숭이에서 혈장 IGF1 수준
Figure 112016006891241-pct00188
내성 연구
체중 및 장기 중량 측정
동물의 전체 건강에 대한 ISIS 올리고뉴클레오타이드의 효과를 평가하기 위해서, 체중 및 장기 중량을 측정했다. 체중을 84 일째에 측정하고 그 체중은 표 115에서 제공된다. 장기 중량을 86 일째에 측정하고 그 데이타는 또한 표 115에서 제공된다. 이러한 결과는, 체중 및 장기 중량에 대한 안티센스 올리고뉴클레오타이드에 의한 처리의 효과는 안티센스 올리고뉴클레오타이드의 기대된 범위 내에 있었다는 것을 나타낸다. 구체적으로, ISIS 532401에 의한 처리는 원숭이의 체중 및 장기 중량에 대해서 잘 내성이 있었다.
표 115
사이노몰구스 원숭이에서 최종 체중 및 장기 중량
Figure 112016006891241-pct00189
간 기능
간 기능에 대한 ISIS 올리고뉴클레오타이드의 효과를 평가하기 위해, 혈액 샘플을 모든 연구 그룹으로부터 수집했다. 혈액 샘플을 48 hrs 투여 후 대퇴골 정맥천자를 통해 수집했다. 원숭이를 혈액 채집 전에 밤새 절식시켰다. 혈액을 K2-EDTA 항응고제를 함유하는 혈관에서 수집했고, 이것을 원심분리하여 혈장을 얻었다. 다양한 간 기능 마커의 수준을 Toshiba 200FR NEO 화학 분석기 (Toshiba Co., Japan)을 사용하여 측정했다. ALT 및 AST 및 빌리루빈의 혈장 수준을 측정했다. 아래의 표는 다양한 시점에서 ALT 및 AST 수준에 대한 결과를 제공한다. 이러한 결과는, 안티센스 올리고뉴클레오타이드가 안티센스 올리고뉴클레오타이드의 기대된 범위 밖의 간 기능에 대한 효과를 갖지 않았다는 것을 나타낸다. 구체적으로, ISIS 532401에 의한 처리는 원숭이에서 간 기능에 대해 잘 내성이 있었다.
표 116
사이노몰구스 원숭이에서 ALT 수준 (IU/L)
Figure 112016006891241-pct00190
표 117
사이노몰구스 원숭이에서 AST 수준 (IU/L)
Figure 112016006891241-pct00191
신장 기능
신장 기능에 대한 ISIS 올리고뉴클레오타이드의 효과를 평가하기 위해, 혈액 샘플을 모든 연구 그룹으로부터 수집했다. 혈액 샘플을 48 hrs 투여 후 대퇴골 정맥천자를 통해 수집했다. 원숭이를 혈액 채집 전에 밤새 절식시켰다. 혈액을 K2-EDTA 항응고제를 함유하는 혈관에서 수집했고, 이것을 원심분리하여 혈장을 얻었다. BUN 및 크레아틴의 수준을 Toshiba 200FR NEO 화학 분석기 (Toshiba Co., Japan)을 사용하여 측정했다. 아래의 표는 다양한 시점에서 BUN 및 크레아틴 수준에 대한 결과를 제공한다.
혈장 화학 데이타는, 대부분의 ISIS 올리고뉴클레오타이드가 안티센스 올리고뉴클레오타이드에 대한 기재된 범위 밖의 신장 기능에 대한 임의의 효과를 갖지 않았다는 것을 나타낸다. 구체적으로, ISIS 532401에 의한 처리는 원숭이의 신장 기능에 관하여 잘 내성이 있었다.
표 118
사이노몰구스 원숭이에서 BUN 수준 (mg/dL)
Figure 112016006891241-pct00192
표 119
사이노몰구스 원숭이에서 크레아틴 수준 (mg/dL)
Figure 112016006891241-pct00193
혈액
혈액 파라미터에 대한 사이노몰구스 원숭이에서 ISIS 올리고뉴클레오타이드의 임의의 효과를 평가하기 위해, 대략 1.3 mL의 혈액의 혈액 샘플을 K2-EDTA를 함유하는 혈관에서 이용가능한 연구 동물 각각으로부터 수집했다. 샘플을, ADVIA120 혈액 분석기 (Bayer, USA)를 사용하여 적혈구 세포 (RBC) 수, 백색 혈액 세포 (WBC) 수, 개별적인 백색 혈액 세포수, 예컨대 단핵구, 호중구, 림프구의 수, 뿐만 아니라 혈소판 수, 헤모글로빈 함량 및 적혈구용적률에 대해 분석했다. 아래의 표는 다양한 시점에서 혈소판 수에 대한 결과는 제공한다 n/a'는, 그 시점에 대한 데이타가 이용가능하지 않다는 것을 나타낸다.
상기 데이타는, 올리고뉴클레오타이드가 이러한 용량에서 안티센스 올리고뉴클레오타이드에 대한 기대된 범위 밖의 혈액 파라미터의 임의의 변화를 야기하지 않았다는 것을 나타낸다. 구체적으로, ISIS 532401에 의한 처리는 원숭이의 혈액 파라미터의 관하여 잘 내성이 있었다.
표 120
사이노몰구스 원숭이에서 혈소판 함량 (x 103/μL)
Figure 112016006891241-pct00194
C-반응성 단백질 및 보충물 C3 수준 분석
사이노몰구스 원숭이에서 ISIS 올리고뉴클레오타이드의 임의의 염증 효과를 평가하기 위해, 혈액 샘플을 분석용으로 취했다. 원숭이를 혈액 채집 전에 밤새 절식시켰다. 대략 1.5 mL의 혈액을 각각의 동물로부터 수집하고 혈청 분리용 항응고제 없이 혈관 내에 두었다. 혈관을 실온에서 최소 90 분 동안 유지하고 그 다음 3,000 rpm에서 10 분 동안 실온에서 원심분리하여 혈청을 얻었다. 간에서 합성되고 염증의 표시로서 쓰이는 C-반응성 단백질 (CRP)을 Toshiba 200FR NEO 화학 분석기 (Toshiba Co., Japan)을 사용하여 측정했다. 아래의 표는 다양한 시점에서 CRP 및 C3 수준에 대한 결과를 제공한다. 이러한 결과는, ISIS 532401에 의한 처리가 원숭이에서 염증을 야기하지 않았다는 것을 나타낸다.
표 121
사이노몰구스 원숭이에서 CRP (mg/L)
Figure 112016006891241-pct00195
표 122
사이노몰구스 원숭이에서 85 일째 (투여 24 시간 후) C3 (mg/dL)
Figure 112016006891241-pct00196
올리고뉴클레오타이드 농도의 측정
원숭이의 간 및 신장에서 전장 올리고뉴클레오타이드의 농도를 측정했다 사용된 방법은 페놀-클로로포름 (액체-액체) 추출, 그 다음 고상 추출로 이루어진 이전에 공개된 방법 (Leeds 등, 1996; Geary 등, 1999)의 변형이다. 내부 표준 (ISIS 355868, 27-mer 2'-O-메톡시에틸 변형된 포스포로티오에이트 올리고뉴클레오타이드, GCGTTTGCTCTTCTTCTTGCGTTTTTT, 이것은 하기로서 지정됨: 서열번호: 2300)을 추출 전에 부가했다. 조직 샘플 농도를, 대략 1.14 μg/g의 정량 하한 (LLOQ)으로 검정 곡선을 사용하여 계산했다. 그 다음 반감기를 WinNonlin 소프트웨어 (PHARSIGHT)를 사용하여 계산했다.
결과는 표 123에서 제공되고, 그것은 μg/g의 조직, 뿐만 아니라 신장 대 간의 농도 비로 표현된다.
표 123
사이노몰구스 원숭이의 간 및 신장에서 올리고뉴클레오타이드 농도
Figure 112016006891241-pct00197
연구 2
5 마리의 무작위로 할당된 수컷 사이노몰구스 원숭이의 하나의 그룹에게 적당한 크기의 스테인레스강 주입 바늘 및 주사기를 사용하여 ISIS 532401 또는 PBS를 원숭이의 캡슐내 영역 및 허벅지 바깥쪽에 피하 주사했다. 원숭이에게 부하 용량 / 주 (1, 3, 5, 및 7 일째)로 첫 번째 주 동안에 투여하고, 그 다음, 계속해서 한 주에 1회 (14, 21, 28, 35, 42, 49, 56, 63, 70, 77, 84, 및 91 일째) 40 mg/kg의 ISIS 532401을 투여했다. 5 마리의 사이노몰구스 원숭이의 대조군 그룹에게 유사한 방식으로 PBS를 주사하고 그 그룹은 대조군 그룹으로서 쓰인다.
표적 감소
RNA 분석
93 일째에, RNA를, GHR의 mRNA 발현의 측정의 실시간 PCR 분석을 위해 간, 백색 지방질 조직 (WAT) 및 근육으로부터 추출했다. ISIS 532401에 의한 처리는 간 및 백색 지방질 조직에서 GHR mRNA의 유의미한 감소를 야기했다.
성장 호르몬-반응성 유전자, 즉 ALS의 발현을 간에서 또한 측정했다. ISIS 532401에 의한 처리는 GHR 수준과 관련하여 30%까지의 간에서 ALS RNA 발현 감소를 야기했다. ‘n.d.'는, 수준이 특정 조직에서 확인되지 않았다는 것을 나타낸다. 간, 근육 및 지방 조직에서 IGF1의 발현을 또한 측정했다. ISIS 532401에 의한 처리는 GHR 수준과 관련하여 간에서 및 WAT에서 IGF1 RNA 발현 감소를 야기했다.
표 124
사이노몰구스 원숭이에서 mRNA 수준에 대한 ISIS 532401에 의한 처리의 효과 (PBS 대조군과 비교된 % 억제)
Figure 112016006891241-pct00198
단백질 분석
IGF-1 및 GH의 혈장 수준을 상기 혈장에서 측정했다. 결과는 아래의 표에서 제공된다. 이러한 결과는, ISIS 532401에 의한 처리는 감소된 IGF-1 단백질 수준을 야기했다는 것을 나타낸다. 혈장 성장 호르몬 수준의 증가는 없었다.
표 125
사이노몰구스 원숭이에서 혈장 IGF1 수준 (ng/mL)
Figure 112016006891241-pct00199
표 126
사이노몰구스 원숭이에서 혈장 성장 호르몬 수준 (ng/mL)
Figure 112016006891241-pct00200
실시예 24: ISIS 안티센스 올리고뉴클레오타이드 표적화 인간 GHR의 점도의 측정
상기의 실시예에서 기재된 연구로부터 선택적 안티센스 올리고뉴클레오타이드의 점도는 40 cP 초과의 점도를 갖는 안티센스 올리고뉴클레오타이드를 스크리닝하기위해 측정되었다. 40 cP 초과의 점도를 갖는 올리고뉴클레오타이는 점도가 너무 커서 임의의 대상체에게 투여될 수 없었다.
ISIS 올리고뉴클레오타이드 (32-35 mg)을 유리 바이알에 계체하고, 120 μL의 물을 부가하고 안티센스 올리고뉴클레오타이드를 500C에서 바이알을 가열하여 용액으로 용해시켰다. 일부의 (75 μL) 미리 가열된 샘플을 마이크로-점도계로 피펫팅했다 (Cambridge). 마이크로-점도계의 온도를 250C로 설정하고 샘플의 점도를 측정했다. 또 다른 부분 (20 μL)의 미리 가열된 샘플을 260 nM에서 850C에서 UV 판독을 위해10 mL의 물에 피펫팅했다 (Cary UV 기기). 결과는 표 127에서 제공되고 모든 안티센스 올리고뉴클레오타이드 용액이 상기 언급된 기준 하에서 그 점도에서 최적이라는 것을 나타낸다.
표 127
ISIS 안티센스 올리고뉴클레오타이드 표적화 인간 GHR의 점도
Figure 112016006891241-pct00201
실시예 25: 마우스에서 GHR의 안티센스 억제의 효과
영장류 모델에서 GHR의 안티센스 억제의 효과를 확인하기 위해, ISIS 올리고뉴클레오타이드 표적화 쥣과 GHR을 마우스 모델에서 결과를 되풀이하기 위해 이용했다.
ISIS 563223 (GAGACTTTTCCTTGTACACA, 이것은 하기로서 지정됨: 서열번호: 2301)는 표적 개시 부위 3230에서 5-10-5 MOE 갭머 쥣과 안티센스 올리고뉴클레오타이드 표적화 쥣과 GHR (GENBANK 수납 번호; NM_010284.2, 이것은 하기로서 지정됨: 서열번호: 2302)이다. 수컷 및 암컷 CD1 마우스의 그룹에게 부하 용량 (1, 3, 5, 및 7 일째에)을 첫 번째 주에 주사하고 계속해서 1 주 1회 용량을 (14, 21, 28, 35, 42, 49, 56, 63, 70, 77, 84, 및 91 일째에) 40 mg/kg의 ISIS 563223와 함께 주사했다. CD1 마우스의 하나의 그룹에게 PBS를 유사한 방식으로 주사했다. 마우스를 마지막 투여 48 시간 후에 안락사시키고, 장기 및 혈장을 추가 분석을 위해 수확했다.
mRNA 발현
GHR, GHBP, IGF1, 및 ALS의 간 mRNA 발현을 측정했다. 결과는 표 128에서 제공된다. GHR의 안티센스 억제는 GHBP, IGF1 및 ALS 유전자 발현 수준의 억제를 야기했다.
표 128
CD1 마우스 간에서 mRNA 발현 (% 억제)
Figure 112016006891241-pct00202
단백질 발현
IGF1 및 성장 호르몬의 혈장 수준 측정했다. 결과는 표 129에서 제공된다. GHR의 안티센스 억제는 IGF1 수준의 감소를 야기했고, 성장 호르몬 수준에 대한 효과를 갖지 않았다.
표 129
CD1 마우스 간에서 IGF1 단백질 수준 (ng/mL)
Figure 112016006891241-pct00203
표 130
CD1 마우스 간에서 성장 호르몬 단백질 수준 (ng/mL)
Figure 112016006891241-pct00204
SEQUENCE LISTING <110> Isis Pharmaceuticals, Inc. <120> MODULATORS OF GROWTH HORMONE RECEPTOR <130> BIOL0226WO <150> 61/842,302 <151> 2013-07-02 <160> 2302 <170> PatentIn version 3.5 <210> 1 <211> 4563 <212> DNA <213> Homo sapien <400> 1 cggcggcggc ggcggcagcg gcagcagcag ctgctacagt ggcggtggcg gcggcggctg 60 ctgctgagcc cgggcggcgg cggggacccc gggctggggc cacgcgggcc ggaggccccg 120 gcaccattgg ccccagcgca gacgcgaacc cgcgctctct gatcagaggc gaagctcgga 180 ggtcctacag gtatggatct ctggcagctg ctgttgacct tggcactggc aggatcaagt 240 gatgcttttt ctggaagtga ggccacagca gctatcctta gcagagcacc ctggagtctg 300 caaagtgtta atccaggcct aaagacaaat tcttctaagg agcctaaatt caccaagtgc 360 cgttcacctg agcgagagac tttttcatgc cactggacag atgaggttca tcatggtaca 420 aagaacctag gacccataca gctgttctat accagaagga acactcaaga atggactcaa 480 gaatggaaag aatgccctga ttatgtttct gctggggaaa acagctgtta ctttaattca 540 tcgtttacct ccatctggat accttattgt atcaagctaa ctagcaatgg tggtacagtg 600 gatgaaaagt gtttctctgt tgatgaaata gtgcaaccag atccacccat tgccctcaac 660 tggactttac tgaacgtcag tttaactggg attcatgcag atatccaagt gagatgggaa 720 gcaccacgca atgcagatat tcagaaagga tggatggttc tggagtatga acttcaatac 780 aaagaagtaa atgaaactaa atggaaaatg atggacccta tattgacaac atcagttcca 840 gtgtactcat tgaaagtgga taaggaatat gaagtgcgtg tgagatccaa acaacgaaac 900 tctggaaatt atggcgagtt cagtgaggtg ctctatgtaa cacttcctca gatgagccaa 960 tttacatgtg aagaagattt ctactttcca tggctcttaa ttattatctt tggaatattt 1020 gggctaacag tgatgctatt tgtattctta ttttctaaac agcaaaggat taaaatgctg 1080 attctgcccc cagttccagt tccaaagatt aaaggaatcg atccagatct cctcaaggaa 1140 ggaaaattag aggaggtgaa cacaatctta gccattcatg atagctataa acccgaattc 1200 cacagtgatg actcttgggt tgaatttatt gagctagata ttgatgagcc agatgaaaag 1260 actgaggaat cagacacaga cagacttcta agcagtgacc atgagaaatc acatagtaac 1320 ctaggggtga aggatggcga ctctggacgt accagctgtt gtgaacctga cattctggag 1380 actgatttca atgccaatga catacatgag ggtacctcag aggttgctca gccacagagg 1440 ttaaaagggg aagcagatct cttatgcctt gaccagaaga atcaaaataa ctcaccttat 1500 catgatgctt gccctgctac tcagcagccc agtgttatcc aagcagagaa aaacaaacca 1560 caaccacttc ctactgaagg agctgagtca actcaccaag ctgcccatat tcagctaagc 1620 aatccaagtt cactgtcaaa catcgacttt tatgcccagg tgagcgacat tacaccagca 1680 ggtagtgtgg tcctttcccc gggccaaaag aataaggcag ggatgtccca atgtgacatg 1740 cacccggaaa tggtctcact ctgccaagaa aacttcctta tggacaatgc ctacttctgt 1800 gaggcagatg ccaaaaagtg catccctgtg gctcctcaca tcaaggttga atcacacata 1860 cagccaagct taaaccaaga ggacatttac atcaccacag aaagccttac cactgctgct 1920 gggaggcctg ggacaggaga acatgttcca ggttctgaga tgcctgtccc agactatacc 1980 tccattcata tagtacagtc cccacagggc ctcatactca atgcgactgc cttgcccttg 2040 cctgacaaag agtttctctc atcatgtggc tatgtgagca cagaccaact gaacaaaatc 2100 atgccttagc ctttctttgg tttcccaaga gctacgtatt taatagcaaa gaattgactg 2160 gggcaataac gtttaagcca aaacaatgtt taaacctttt ttgggggagt gacaggatgg 2220 ggtatggatt ctaaaatgcc ttttcccaaa atgttgaaat atgatgttaa aaaaataaga 2280 agaatgctta atcagataga tattcctatt gtgcaatgta aatattttaa agaattgtgt 2340 cagactgttt agtagcagtg attgtcttaa tattgtgggt gttaattttt gatactaagc 2400 attgaatggc tatgttttta atgtatagta aatcacgctt tttgaaaaag cgaaaaaatc 2460 aggtggcttt tgcggttcag gaaaattgaa tgcaaaccat agcacaggct aattttttgt 2520 tgtttcttaa ataagaaact tttttattta aaaaactaaa aactagaggt gagaaattta 2580 aactataagc aagaaggcaa aaatagtttg gatatgtaaa acatttattt tgacataaag 2640 ttgataaaga ttttttaata atttagactt caagcatggc tattttatat tacactacac 2700 actgtgtact gcagttggta tgacccctct aaggagtgta gcaactacag tctaaagctg 2760 gtttaatgtt ttggccaatg cacctaaaga aaaacaaact cgttttttac aaagcccttt 2820 tatacctccc cagactcctt caacaattct aaaatgattg tagtaatctg cattattgga 2880 atataattgt tttatctgaa tttttaaaca agtatttgtt aatttagaaa actttaaagc 2940 gtttgcacag atcaacttac caggcaccaa aagaagtaaa agcaaaaaag aaaacctttc 3000 ttcaccaaat cttggttgat gccaaaaaaa aatacatgct aagagaagta gaaatcatag 3060 ctggttcaca ctgaccaaga tacttaagtg ctgcaattgc acgcggagtg agttttttag 3120 tgcgtgcaga tggtgagaga taagatctat agcctctgca gcggaatctg ttcacaccca 3180 acttggtttt gctacataat tatccaggaa gggaataagg tacaagaagc attttgtaag 3240 ttgaagcaaa tcgaatgaaa ttaactgggt aatgaaacaa agagttcaag aaataagttt 3300 ttgtttcaca gcctataacc agacacatac tcatttttca tgataatgaa cagaacatag 3360 acagaagaaa caaggttttc agtccccaca gataactgaa aattatttaa accgctaaaa 3420 gaaactttct ttctcactaa atcttttata ggatttattt aaaatagcaa aagaagaagt 3480 ttcatcattt tttacttcct ctctgagtgg actggcctca aagcaagcat tcagaagaaa 3540 aagaagcaac ctcagtaatt tagaaatcat tttgcaatcc cttaatatcc taaacatcat 3600 tcatttttgt tgttgttgtt gttgttgaga cagagtctcg ctctgtcgcc aggctagagt 3660 gcggtggcgc gatcttgact cactgcaatc tccacctccc acaggttcag gcgattcccg 3720 tgcctcagcc tcctgagtag ctgggactac aggcacgcac caccatgcca ggctaatttt 3780 tttgtatttt agcagagacg gggtttcacc atgttggcca ggatggtctc gatctcctga 3840 cctcgtgatc cacccgactc ggcctcccaa agtgctggga ttacaggtgt aagccaccgt 3900 gcccagccct aaacatcatt cttgagagca ttgggatatc tcctgaaaag gtttatgaaa 3960 aagaagaatc tcatctcagt gaagaatact tctcattttt taaaaaagct taaaactttg 4020 aagttagctt taacttaaat agtatttccc atttatcgca gacctttttt aggaagcaag 4080 cttaatggct gataatttta aattctctct cttgcaggaa ggactatgaa aagctagaat 4140 tgagtgttta aagttcaaca tgttatttgt aatagatgtt tgatagattt tctgctactt 4200 tgctgctatg gttttctcca agagctacat aatttagttt catataaagt atcatcagtg 4260 tagaacctaa ttcaattcaa agctgtgtgt ttggaagact atcttactat ttcacaacag 4320 cctgacaaca tttctatagc caaaaatagc taaatacctc aatcagtctc agaatgtcat 4380 tttggtactt tggtggccac ataagccatt attcactagt atgactagtt gtgtctggca 4440 gtttatattt aactctcttt atgtctgtgg attttttcct tcaaagttta ataaatttat 4500 tttcttggat tcctgatagt gtgcttctgt tatcaaacac caacataaaa atgatctaaa 4560 cca 4563 <210> 2 <211> 303000 <212> DNA <213> Homo sapiens <400> 2 gccatctact gagatggaaa tgtcacccac tgtgattgga gtatgtttaa ggagaaagaa 60 ccagagttca gatgtggaca tgtcaagttt cagaggtctg ttagacatcc aaatggagat 120 acccagttgt tagcctggag ctctgtggag agatctgggt tagagatata aatccaagag 180 atacaacttt tcattcaatt tgattattta ttggacgctt tataaactct gtaaatactg 240 ggcactaacc tagacattgc aggtacagat attaagaata tatagtttct ccctcagaaa 300 tctcttaatt aatgagaaaa gcagacatgt caacaaaact gcaatattta ataaaagaag 360 atataaaggc ctataaaggt gctgatacag ggagaattaa ttaattccac cctggggaat 420 agtcaggaag accttcagag agaaagtaaa caattgattg gaactttaag attaagaagg 480 atttctctgg gtggacaaag taggatcttc caagcagagt ggaaaccatg agcaaatgca 540 gtttcattct tcagaaggta aatgtgctct ggcatgcctt aacttataac aaattaatca 600 actcaatacc tgctacattt tccctcacaa tttggaatat ataaagaggc acatactact 660 atggaccaat acctggtcat atatgagatt gaaggacctt tacttacgag gcttaaaaat 720 aaagactgcc cttcatgtca gttgcaggtt tatatctagt tctatagtat taactgaggt 780 gtcttttcct atgttttctg tgcatgatga ctttttaaaa atcaaagaca gagcagcagc 840 cagagtagtc tagtttcatg gcacacagaa tggaggatat tgctgaaccc agatttaaaa 900 aaaaaaagaa gtcaattctt atttttttaa gtatggccct gagctcatct cagagcataa 960 acaatagaat ttagaatatc ttttatgact ccgtctggca cctcctaaac tagatcaaga 1020 ttctctagct cagggaagaa gggcaaagga tgagaaggca cagagaggat ataaacagag 1080 aggttggtag tgccaggctc tgaagaaggt ccaacttgga aggtcatttc agacaggcgt 1140 ggagtcagca tttgaggcct gtctggtctc tactcctgcc aggactaccc tgtcagccag 1200 cttggcaggt atggaccacc cagcaggagt ttttcttgac tgtgccctaa tcttttactt 1260 tcccaagttt ctctatatgg gtacctcccc ttttaaaagc tccagacaca gccaagcacc 1320 actattgctc cagcaaagta tgaagcccca gaaatcaatg gtttggggaa gagtcttagg 1380 ggaactaaat gcctccttat ttttagatgc catagaacaa gagcagttca ggatcaataa 1440 ccatcccacc ccatgataaa acacgcccct tccagaatct ttcctttttc gttcattcta 1500 ggtgtctgtc tggaacagct ggggtatttg agccacagct gagcttctga aagcattcta 1560 aggaacagtt tttcacttat ctgattcctt tgaaaatagg ggtatcttat gtgatatctg 1620 ctatcccaga gtctttggtc ctctgttcct tctcaagtct tggctcccgt gtactacttc 1680 aaagccctat agatatttta ttctaaagaa aagaaacttg gttcctttaa gttgtttaaa 1740 catttctttc tgggtataaa cttgggtttg tgtctgggag ctctgttaaa aaaaaaaagt 1800 ctttagtaag ccaaagctgt tagaagctta taagtaagtg acattacaat tgaccgtcag 1860 taaatagtgg aaagattgca tgactagcta ctccttcaga tctgagacaa cctggagcta 1920 gatttttgta ctctctactc agaaaagcat atagtgactt ggggtttgat gctgtacaaa 1980 aatgacatgc ttatgcacaa ctttaacttt ctgcaacact tttacaactt cttgtgaatg 2040 aagtaggcag ggctcgcatt tgacagatga gctatgtcca gcgtgaggca gagttaaaac 2100 ccttttcctg gctcaggaac ttcaggctgg ggcctgtgtc tgctctccct gcatccctgt 2160 cctctagcag atacctctct gctaacatgc tgagtgtcct tggtaaatta ctcattctct 2220 ctgtctccgt cttctaacct ccacaataaa gtccttcgta gttttaacta tcttttcact 2280 gtgccccagt gagcaggagt ttggaacttg attgttgatg gaaaggcaat atttggatgg 2340 ctaaacacgc tttccaaggt atctcgctga tcttcctctc attcctggag atagctaacc 2400 tttttgtaag tgtttctttg agtctgtgga ctgcacttaa cgctcttgta ggtcctgctt 2460 tcatttggaa cgggcaggcg gagaggaagg aagtgtattg caactaccaa tattttcctc 2520 taggaggagc cgcgcagctc agttgagagt gacacgcacc aactccagct cctcgccggg 2580 aagacttcat cccagcaact cggaatgctt ggcccgggcg gcactcggcc tctccgcagc 2640 agttctcgaa ctggcctcct tgaacgtccg cttcgccttc gcttctgcaa cctggatctg 2700 ggggactgcg ggccaggcgc ggcgtgaccc ctggtgaacg gtggccgcct tttcccaccc 2760 ctgccctccc atcctccctt cccgtttcac cccgccccct ctctcctccc caagcctgac 2820 agcccgcgag ctgccaagca gggcgcagcc atgggaagag gaggagggct agggagcggc 2880 ggcggcggcg gcagcggcag cagcagctgc tacagtggcg gtggcggcgg cggctgctgc 2940 tgagcccggg cggcggcggg gaccccgggc tggggccacg cgggccggag gccccggcac 3000 cattggcccc agcgcagacg cgaacccgcg ctctctgatc agaggcgaag ctcggaggta 3060 ctggagtggg gctccgggag tctggcttta ttttcctcct gttgtgccag ggggcctgag 3120 ggtgaaccct gggactctag ttgtttatga aaacgggagg atctgtctta tatatttaca 3180 cggataattt tttattccgg atgacttggc tgtgctcccc tcctccttgc gaagaagttg 3240 ttttctgctg gtgggttgtt gtaacccaat ctagtgtgtg tgtgtgtgtg tgtgtgtgtg 3300 tgtgtgtgtg tgtgtgtgtg tctggaagtt ggtgagggcg gcagggagtt gcgggcgaca 3360 gacgaaccat cacactctgg cgtctgctct ggcccgcgag tagtgtacgt ggaggggttt 3420 actccggaga cagttttgtt aaagtcataa aagttttgct agtgtgtttc tgtttgccat 3480 catctgcctg gctgcggcag gaactgccga ggctgctgct gttgcgcggg gaagaatccc 3540 cggcagcgcg actggagaga ctggggaggt cgagctgtgc gcgtggacac agcgcgcaga 3600 gcgcgcggtc ttttgcgcgt ttgtgcgggc cgcagccgca cgttggcacc gatggaactg 3660 gggtcagtag agtgacagcc accagtccgc atgaactggg gtaagtggaa attgtggcga 3720 gccgacctcc cccagctttt gacacactag tggttgtaaa atcaaccagg cttaaagttt 3780 tgacagaact gccagaggct gcgggtcaat ggggtggccg cgtgtctagg gagagggcgc 3840 tggcggcgca gagggtgcgg ggcagggcac ttgcgagtgc gtggggaagt ctatttgggg 3900 cgagtgcttt atatatagcc cgaggggatg cctgctgaga ccgagctgcg ggggctctcg 3960 gtctggcgcg gactgtgtgt cctgaatgag tgtacgtgtg cgctgtgtgt gcgcgcgcga 4020 gtgtgcgcct ggggaggcgt gtcggcgcct gagccagtag ggtgtgcagg gtggaagagg 4080 ccacagaggt gccgcctgtc tgtttgtgcc gccaggagac cttggaaggg acagagaaag 4140 gtaacggaag gccaaagtgt tgggaagtca gagtagtttc tgcataggat taagtattaa 4200 gggctttaaa ataactaaac gcattgccct gagtggctga ggactggaag tgaggttttg 4260 gggagttctc aggagaactg catgggaggg cgtttgggag gtctaaggga tgtgtaatat 4320 gtgtgagtac agaacttcgg agacagacac aggttggagc tatgaatttg aaattttcag 4380 ggtgctgctg tccacagtcc agggactggc tggtttcaga ggtattcagg ctccctggtg 4440 tgtgtgcctg ggaagacact catcttttct tgcagacatg ggatattgtg gcaggtcagg 4500 ctctgtttcc tgagcaactg gtgttccagg ctagtttcca cctgaatcac cctagaagtg 4560 tcttttttct gatgataaat gttgaaacct ttccagaaat taaaatgctg gatagaaaca 4620 aaattgatgc agcagacagg attgttgatt ctatttattc agtgattggg agctcttttt 4680 ccttttgaga aaagcaaagc tcagtgtttc cagattagat ttcaaggagt cttcagctat 4740 ctacagcttc ccttctgggc ctttggatgg agctggaagg atgtgttttg gcctaaagac 4800 ctttggaaga catcatgtgt agcttaaaga ggttgtcccg tctctcatca tcttcttcca 4860 cccttataaa ctttttgttt tgcattaatc taaggaaagt tggtgtgtca acatttagct 4920 tttttttatt ggagtaaata tatcacagtg aaattatagt tatggtctcc tgaagcccat 4980 ggaaagccaa cacttaatgg gcaaaggtgt gaaatgaaag tctataaatg caatgacaaa 5040 gtgacgagat gagtgcattc ttttttcaaa atgaacataa ctgtgctcac aaaaatttgt 5100 tttagccagg ctttgggccc atgtttttta ttattagttt ttaaacagca gactccacat 5160 cataaaccac tttaaaatgg atactagagg cctcctgtat gctatctctg gcgcctgctt 5220 aaacagatgt ttacagtgct tggtaaccta tgggattgtc atgttgagta tcttgttagc 5280 tcaggacata atgtttatag cataatataa taaatggagc cacagttgca gcgtgcttct 5340 tccaagtgca tgaagcaaat cttgcagcag ggaaacaaat cttgcagttg gtccaacttg 5400 gctagccttc tttggctatc tcctggtgag caatgttaat gtaaagataa atgtgagtga 5460 cgtagtgaga aagtgggaca gtaaattgtt tagcttagtg aaaaaagcat ggattatgtt 5520 ttttaaatct gctaacctga agattacact tctcaggtcg taccactggc aaattgcaca 5580 actatgggaa tttggtttgc ttttaaagag caatttttaa aaagtatgtc agtaatgaaa 5640 ataacttata tttcttaatg tgtttatgtg tgtccataca agccaatact ttttcttctt 5700 taaaaagaac cctataattt ctgtggtaat tatttaaata ttatgagcat tcaaatctcc 5760 taatcacctt ttcaatcttc aattgataag aatcgaagtt tggtaagact ggagtcatcc 5820 ctcagccaat tgtgtaaaca agacagtaca gaatgtcttt ctggcaagta atttttttca 5880 acctgaaaca gataatataa ataatatgtc ccataaaaga attacttaag atgataatta 5940 ctttagaggt aattatctgg tgcatgaacc tctatctgtg aaaatggtct agtctatctc 6000 ttattggaaa taatcagttg gaaatctccc tttttcattg gtcagtccat tctaggaaag 6060 attcatttct agaaagttct tatactgaat caacattttc ttccatccac ttgcctatcc 6120 ttcagcagct gaccacaatg aatctagtct cttttccctg tgtttaccat acttgaaaac 6180 aaatattatc ctccttgccg aatccccttt tgcctactct tggagcagtt tttcatccac 6240 tatagggttc caccctcctc tgccttgaac aagatgccct tgattgtaca ttctcattgt 6300 attagtctgt tctcatgctg ctaataaaga catacgtgag actgtgtaat ttataaagaa 6360 aaagaggttt aatggattca cagttccaca tggctgggga ggcctcacaa tcatggcgga 6420 aggtgaagga ggagcaaagg catgtcttac atgacagcag gcaagaaagc atgtgcaggg 6480 gaactgccct ttatagaacc atcagatctc attagactta ttcactatca tgagaacaac 6540 atgggaaaaa cccacttcca tgatttaatc aactcctact gggtcccttc caccacatgt 6600 gggaattatg ggaactacaa ttcaagatgg catttgggtg gagacaaagc caaaccatat 6660 cattccgctc ctagcccctc ctaaatctca tgttctcaca tttcaaaacc aatcatacct 6720 tcccaacagt cccccaaagt cttaactcat ttcagcatta actcaaaaat ccacagtcca 6780 aagtctcacc tgaaccaagg caagtccctt ccacctatga gcctgtaaaa tcaaaagcaa 6840 gttagttact ttctagatac aatggaggta caggcattgt gtaaatatgc ccattccaaa 6900 tgggagaaat tggccaaaac agaggggcta taggtgcaag tccaaagtct aatagggcag 6960 tcattaaacc ttaaagttct gaaatgaact cctttgactt catgtctcac atccaggctg 7020 ttttcatggc tggcattgac tgtggctttt ccaggcacat ggtgctaact gtcagcccct 7080 accattgggg gtgctgggga atggtggccc tcttctctta gctctactag gcagtgaccc 7140 actggggact ctgtgtagag gatccaaccc cacatttctt ttcctcattg ccctagcaag 7200 ggttgtttat gagggctctg cccctgcagg acaactctgc ctggacatcc aggcatttcc 7260 atacatcctc tgaaatctag gtggaagttc ccaaacctca gttcttgtct tctgtgcacc 7320 tgcaggacca acaccacatg gaagcttcca agacttgggg ctttcaccct ttgcagccat 7380 ggcctgagct gtaccttggc cccttttaga catggctaga ggggctggga cacagggtac 7440 caagtaccta ggctgcacct agcaggccca gaaaaccatt tttccctcgt aggcctctgg 7500 gcctgtgatg tgaggggctg ccataaaggc ctctgacatg ttctggagac attttcccta 7560 ttgtcttggt gaccaacatt tggcttctca ttacttatgc aaatttctgc agcagtcttg 7620 aatttctccc cagaaaatgg gtttttcttt tctatggcat catcagcttg cacattttcc 7680 aaacttttat gctcttttca cctcttgaat gctttgctgc ttctaaattt cttctgccag 7740 ataccctaaa taatctctct caagtttaaa gttccacaga tctctaggac aggggaaaaa 7800 tgccaccagt ctctttgcta aagcattaac aagagtcacc tttgctccag ttcccaacaa 7860 gttcttcatc ttcatctgag accacatcag cctggacttt attgtccata tcactataag 7920 cattttggtc aaagccattc aacaagtctc taggaagttc caaactttcc cacatcttcc 7980 tgttttctga gccctccaag tctctagaaa gttccaaact ttcccacatt ttcctgtctt 8040 cttttgagcc ctccatactg ttcaaacctc tgcctgttac ccagttctaa agttgcttcc 8100 acatttttgg gtatctttac agcagcacca actctaccat taccaactta ctatattagc 8160 ccattctcat gctgctaaca aagacatacc caagactggg taatttataa agaaaattag 8220 gtttaatggt cgcacagttc cacatggctg ggaggcctct caatcatggc agaaggtgaa 8280 ggaggaataa ggcactctta catggtggca gacaataagg catgtgcggg ggaactaccc 8340 tttataaaac catcacatct catgagactt aatcactatc gcaagaacag catgggaaaa 8400 actcgccctc ttggttcaat gacctcccac tgggttcctc ccatgacaca tggggattat 8460 ggtagctaca attcaagatg aaattggggt ggggacacag caaaaccata ttactgactg 8520 tccctcctaa tgtgtgtttt ctaaacaaaa gatttataat ttgtagttct gaacattcta 8580 tatctattaa gacagtttaa tattaatgaa attctttagc catttcatta cgctcttgat 8640 taatttcata cctataaaca agataacttg ttcttttcag attattaatc atccatagtc 8700 aaagcatttt tataatagct tcaaaacatt ttttcatgcc tgaatgtact ataaatttat 8760 ggaaagtata atactgtgtg ggtaaataaa attctataaa cagtgcaaat agtgacttaa 8820 tttctcccta tcaaggaata tcaaccccaa atataccgaa agtagaatgt tccaaagata 8880 aacaagttga aactacatgt tatagacagg tagggactat gatgtatttt tttcataggc 8940 ctcattgtgt ctgcttccat gaacatgagt cagtactagc aatcaggcat ttattgaagg 9000 cttgttctgc caaagtccca gagagtatgc catctggcct taaatgaagt gaaagtacat 9060 caaataaaga tacttccttg ggcaactggg atttaagatg tgcatgcagg acatgtctaa 9120 gtcagccatc tactttttct caggaggtaa atggcttgcc aatgccacag gaaagtctaa 9180 agtgttcaca ctccataagc aggtcccatg tcctgttgta ggtctggaca ggagctggac 9240 aaaggccctg ttactcttag cttaccaagt cttagctgcc ttggaagaag atagcaaatc 9300 tggcttatcc agaggagagg cctgaagtgt gcattgggca cctacctggt gtgactgatt 9360 tctcttttat gtatctgtct tgggcttcca gctaaattgt gaattcccct tgccaccaag 9420 ctaagaatct gccacagcat tgtcttcctg cacacacaca cacatacaca cacacaaaaa 9480 catatatgtt ggatgatgaa gagacaatgt cagtttttca gcaagtctga atgtgaaaca 9540 aatggctatg tttcttggtg cagtggggtg ggaggatgag agagaaaaaa caaacctgtg 9600 atataaactg acatctgagc ctaccaaaag ccctttgaga gacctttgat caagacaagg 9660 ggataatcat agtgttgtgc acttagataa aattgtccat gctagtcccg tgtgtgtgtg 9720 tgtgtgtgtg tgtgtgtgta tgtgtgtgtt tcttcacttt atccccagca ttatggtctc 9780 aattcataca catttgcttt tttgctttat tctagtctga tatgaaggga agaaataagc 9840 aatgattcag ttcctttttt tacatttcaa acattcattt cactactccc cacctcccag 9900 tcctcacccc ccaaaattac aagagaccca ttggcaagta cttggacatg caattttcaa 9960 accaaaggtt tactttgcta taagaaacgt ctaagttagg atgatataat atgaaataat 10020 agtaaattag atgtcaagaa acttgggtcc tctccaagct ctgcctttaa tgggctttgc 10080 agtttttgcc aactatttaa ccttcctggg cttcatattt cttgtatgtt aaaaacaagc 10140 aaaaaggaga agtaaacaaa atgacccctt agaattctct tcagggctat tgtttgaatc 10200 catttaatta tcaaatttct ctcttctttt aaatgtaagc atcaaaaaat gtttgcctat 10260 tttattctct catcattaat ttttaatcaa ttaaataaaa tagataaaaa ttttatcaaa 10320 accatgcttc ttgctttcat tctaaaacaa tgcaactcat cactatctga tgcagaaagt 10380 ctttctgaaa tattgttttt ctcttttgtt gttgtttttt tctttgtgct aaagaaaatt 10440 cattgatgag taccaggttc ttcaaagaag gatggaaaag tcattgtttt ttagtctcaa 10500 cttctttctt cagtgcttct tcctaccttt taatataggc aaataaagcc ttaggccagg 10560 cactaatttt acttagtaat gattcataag aaggtagtga ttttgtcaga aattgctggc 10620 tgcatgcttt taatcagcat ctaaacttac cttcaaatac tccattccaa aatcagcaga 10680 taacttcttc tacagagtct ttcaaacttc cagatgtgtt tactgttttg attagggctt 10740 tcttcttttg ttgttgataa gacttcagcc agttttcttt aggctaacat tattatattc 10800 ccaatgaatt atacttctta ggttgtgaat ttgtttaaag ataaatctat ctccagctgg 10860 ctggcttcta agtaaaaagg ggtatcctag ggaagaagtg cacttcacag ggattcagta 10920 caggtgtaga gaattccctg atagagaatt ggaacacatc aagagtttgc aaattgaaaa 10980 ggtactttta tgtacttatc catggtggac aacctgtgtc ctagggaaga agcgcatttc 11040 acagggattc agcacaggtg tagagaattc cctgataggg aactggaaca catcaagatt 11100 ttgcaatctg aacaggtact tttatgtact tatccatggt tgacaaccta ctgtgctaga 11160 catttgctgt agtaactcct tgattttttc ctcggttgtt tataaaatta aacatttgaa 11220 gtagcctatt gaaaagtctt aaaagaagca tctcctctat tcctttagaa tacagtatat 11280 taaacaagtg ataaagtcca aagaaaaatc cttattcttt tcttgcttta aaaaatgcac 11340 tttattttat taagcattat atctatcttt taaaactttg aattgccata tcaatgaaag 11400 tagagtgtta tcattacaaa acagaatcgc agatagttct ttccctgtgc ttattgagag 11460 aaaaggtgca taattgatgc tgtaaatgat catcttgaat ttgatgatgg ctggtgagaa 11520 acctcagtca gacattcaat tttgattgcc attggtcaga aaggcagcct ttgttcttcg 11580 tcactatgtg gcacatgatc ctaattcacc ctatcagctg cttctctgca cactttcaag 11640 ctatgtgatt gttatactag aaagcctcta agttggccaa actaatgaag actaatctga 11700 caaagcatat gtgaatgata aattctgtaa agaccgtgga gatagagcct ctgcagtggc 11760 ttcttcccct ggggatagaa gaagatacca gaatccctgg gcaagatgaa atagataaag 11820 gaaaggcatc atttttatac ctaggaaatc agaaagatta aagaaagaga agcaagaata 11880 aagaagaact actactttca tagttcattc tttcaatgta gcaccttatt tcccatagag 11940 acattggtga agccatgctt ttctttgcca tagaataggt gttcagtaaa tattttgcag 12000 gtggccttaa tatgtagtaa aacatacaga aatatggaag cattgacaag aagtttgtgg 12060 ataatttgag ggcaaaagga tgtagatagg atcaggttca taatgcaaat ttgctattat 12120 tctccttaga ttaatgatgt cactcaaact tcatgacctg ctttccaagg tgtatgctgt 12180 tcacagcctt ggaaacattt agaagttttt agtacttgga gcaagatgga tatatgtttc 12240 acattttatc taggacttag taggacttgg gagacatatc tactttgcca gatcttagta 12300 tacttattat ggagcatgac attttaattc tctttgcttt tgtcctacaa agtttagtgt 12360 tttaatttat ttttctcggt gcatataggg agagaattat ttatataatc tgaaaagtac 12420 tttgaaaact acttgggaaa atatgttgaa taaataagtt tttttttaaa ttagcctaca 12480 ggatgtaagt ctggccaggc tagtggtatt tttggtatca ttgtgaaaaa tcaaaaacag 12540 aacatgtatt tatcaatcca ttagtgtgtt cccaggaatg tgctagacac tagggaatta 12600 aaacatgact cttgacttta gtaccaagca ttcaagctag aaggcaacac tattaatgta 12660 cattcatggt gtgattatgg aacagtcgat gactgtacaa cttaatgaaa agttcattag 12720 agactataaa tgctacattt atttagagag aaggacaatc tgtttggact gagggattgg 12780 aagagtggcc ttcatgggca acatggctcc tgagccagta cttaagatat ggtatttttt 12840 tttttttttt ttttttttgg ttaggtagaa gggttggaga ggtttcatgc aaggagttag 12900 gaactgagga ccaggaggcg tatcttgagt tcactggggt tactggtaat agggaggagg 12960 cagagagtac caggctgtgg atttgttatc cgttggaagc tcttcccatt gcttattatg 13020 gtcgctgcat ataggctcat cccttgggta gggctattgg agtggccacc ctgaccctat 13080 tgctgattgg atagtggtgg ctgctgtgtg gtatttcagc acatttatct tttctgaaca 13140 ttatgtaaat tcagtctgaa aacttctttc ttaaacaatg ttccaagagg cctattaaag 13200 atgccaacaa tatgacttcc attcaagaat atgatcttga atgggcttta caatggcaga 13260 gctgacctga gattacctcc tctgctcctg ctctcaagcc atgtgctgat gctgacagtc 13320 ctggcccaat agagccatag ggcctcacag aacttgagat catctaccag tggctgtcaa 13380 ccaagccact cctttctgct aggtagtgca tagggacatt gggaaataca gttattataa 13440 gaactggaaa gagttgtagg cttttggtgc ctgaagtcag aaatgctaaa tttctgtgat 13500 gccaggggca gtcctatata agaaattatt gtgcctcctc aaatgccagt agatccctat 13560 tgaaatactt gagtctcata tcctcacttt atttataggt gaggaaatgg gaggccctga 13620 gaagtgacaa aactttcttc taggattaaa cttcacagtc tcagtgacag atttataact 13680 caattctttt agttttcttt caagagctct tgttgcagca ccacagtccc tcctattaac 13740 atgggctata actatggaat agcatgttgt ttatctctgc catttttata gaaggatgat 13800 agttagctat gttaactatc tgaatgggtg gaatgtgaat tgagataact ggtacttgac 13860 cagcagttct ttcgcctggg aacacacaca gattcacctg taaattaggg ttggcagatg 13920 cctgttgaga tgtcaaccat agccaaagct tacaaattgg ttgacttttt ggaaagggca 13980 tggagtaggc tttggattca cacaaatctg cttgtctgac cggatttgaa tacaaccctt 14040 cttatcttta ctatctttgt gactctcagc caattaaact ctctgagctt tatctgcaaa 14100 aaaacagttg attattctta tttcacaagc aatgagtcaa aatagtgcct ggcacatatt 14160 gggcactgca gatatagaga attccctaca gtatcttttt gagcataaag acttgaaacc 14220 ttcacttata aaagaccctc ttgataacag tcgctatttt tttctcctcc tttccccaaa 14280 caacgaaact agggcttcag tgagtccctg aagtgtttac tttgtttgaa ctgttgagat 14340 ttccctcctc cagaagagtc ctgctggcca gagatgagtt ccttttgact tctctgtcaa 14400 cgtgcctgta ttattgtcac atagtaaaaa tgaaagatat atctagatga ttattagcag 14460 gttatgaaac ttagatttta aagtcaataa taaaagccat tcctgggtag agaagttttt 14520 cagagagatt tctaccttgc cagcgatgag agagcctact taggtgaggt gaatacttta 14580 ggcaagttaa gggataacac aatataattt atttaagtaa gttttttatc tgggactaat 14640 ttcaggtttg cagaaaagtt gcaaaaattt tagaggtcct gtatattcct cacctagttt 14700 cccatgttga catccataat catgatatat ttgtcaacac taagaaacca atgttagtac 14760 agtactatta actaaaatcc agacttcatc ctaattcccc cagagcttcc actcacatct 14820 tcttttctgt tccaggattc aatccagaag cgtgcactgc ttttgatttt atgattttta 14880 aatactgtgc atgtgctttt ttaatttggg ccctctcatg tgttaaactt accggccttt 14940 gtaaccagat agcaagttct gtaacagaaa atacaatgat gttgaatcca acatcatgct 15000 gggcacaaag tatgttctcc aaactaatta aatttatcac agcaacaaga acaaagtttt 15060 actcagcgta catatgtagc tgagtcctca ttggtaagct aagaggtagt cataagagtg 15120 ggataacttg gaagaaattt gattttgaat gtgtgccctg aacattggta taaaacagga 15180 ccccctaaat catatatgaa ctgagtctgt acactgtgcc tagcattgtg tgtgcatatc 15240 acacttactc ctgataactg taaggcacat agccttgagt aacttagctg aggaaatgag 15300 accaagggaa gttaagttac ttggccaggg attcacagct agtaacacag ctgagattaa 15360 aacatatgtt tttctggctt cagagcctac actcctaatg ctgtattcaa ttactcccac 15420 acttctccac ttgcttaacc cctattcttg gtgtcctttt tctaggtata cagaatttga 15480 aaactatatt gtcaaactac agcagacctg gatgcatggt atacacttct ttgtgagctg 15540 gattaagttt cagccttgaa tttgtggatt attttcaaaa cctgcctaac atctgtaaaa 15600 catgttgttt ttttaatatg tagatatcca cataaattga ccacaatgct cttcagaaag 15660 tcccataatc caataataaa taaatttttg atacatggct aataacaggc acagaagcat 15720 ctccaaagga caggacattg atattgtgta ataatttaaa gtattttatg attgtataat 15780 gtgcctgagt tttggatagt tgacctctat ttctcagtct ttacatagtt actgcttttt 15840 taagtgttac atgagggatg tggaatattc agtgtaacat ttgactaatc tttatgtttt 15900 gagtggccca actgaaaatt acccttggtt gccttggaac tctgggcatg atgttcaaaa 15960 ctagaaattc ttgcaaatta tttgagcttt ggctctggga agataaacaa catgaataac 16020 taggttaacc agggctgaaa tttctctaac ctataattct aaattcagaa aagaatgggc 16080 tttagggttt tttgtttatt tttgctttga ttacaagttg ttggaagcct agagttagta 16140 tctaataaca caatctatgt aaaacacaaa ttattggctc agaatgatat ctaatttcta 16200 agaagatatg aggaggcaat catgtaaaaa cgtgcttttc ttcctagaag gaataagctg 16260 ggattggcca aaaggtaatc cctttagagt ctaatgttta gagcattgca tatttttaaa 16320 gaagacatat taccttttag aacatatgta ggaaaccatt ttctttgctt atatggctac 16380 ataaagttgt catggtttta aaccgtgacc ttagatacct tatagaagta attacaggca 16440 caatctgtga atgaagattt gcaaactatg cttcaccaag cctcagggac tattggatgt 16500 ccagaggaca gagccatgtt ggatgtctta tgggccttca gtcctgcaaa gtggtgtgct 16560 ttcatgtttt acacacagca gttctgagaa aatttaagtt gaaaaaacag cctctcttct 16620 tattattttt atatttattt atttatttat ttatttattt atttatttga aacgaaatct 16680 tgctgtgtca ccaggctgga gtgcagtggc gtgaacttgg ctcactgcaa cctctgcctc 16740 ccaggttcaa gcgattctct tgcctctgcc tcctgagtag gtgggactac aggtgcaggc 16800 caccacgccc agctaatttt tgtatatatg tatttttaat agagacaggg tttagccagg 16860 ttgcccaggc tgatcttgaa ctcctgagct caagtgatca gcccacctca gcctctccaa 16920 gtgctgggat tacaggtgtg aggcaccgtg ccgagccatc ctgtcttctg aaaaaaaaaa 16980 aaaagcaaac aaaaatgttt aagcctggta tatattttct tatattgcat aagctacttt 17040 tctgactgcc tctctttaga aattcctctg atttctagag aaaaaaaaat cgcattagct 17100 ttttggtttc taaattcagg ctcactttag taactgctag attataaact cttagaaggc 17160 aaagggctat gtattctcta cttgtggaca ctcaattagt ttgcttaagc aattacttct 17220 gtgtaagcaa cattaatgaa gtgcttacta tgatcaaggg ctataccaag tcctttttta 17280 tattatttaa tcccacacaa aacccatgat cgacctaatt gtacacttgg tgaaactatg 17340 atgtagggag gttaaataat ttgttcaaga acccacagct ggtaagtcgc acagtgtatt 17400 caaacccaga tcttcctaat tgcaaatgtg tccaactccc atgcttctaa ccactgccta 17460 tgtgatggtt ctttgaaatt cctccctcca agaagtggaa tttaattccc cccgtccatt 17520 gaatgtgggc caaactcagg tgactcattt ctattaaatg gagtaaagtg gaagtgaaga 17580 tgtgtggctt tagcgactag gtcattcaaa gtggctcctg tcttggttgt tctgtctctt 17640 atacctattg ggcatttaat ctggggaaaa ccagctgcca tgttttgagc tgctctgtgg 17700 aaaggctaac atgaaaagat actgtggatc ctacagacag cttcaaatga ggacctgagg 17760 ccctcagacc agtagccagt atgaaactga agcctcttga ccacagcctc catgagagta 17820 atggaatctt gaccccctag tgaaccacag cctccatgag agtaaaattc aagatggagc 17880 cttgacaccc agtggagcct cgagatgact gcagtcttcc accaacagct tgattcatga 17940 aagaccatca gccagagcca cccagctaag gtgattctag gcccctactc ctagaaaata 18000 aatatttgct gttttgactg ccaagtgttt gattaatttg ttacgcagca atagataaat 18060 aatgcagcct aacactgtcc tggtcatttt taaaaaagaa attgttttaa ttttactaaa 18120 tcacaaattt taaaacattg atacagcaag gagaaacttt ccagaaaaaa aatgctgcca 18180 aatttaagta gtaaaatatt aatgtccaaa aaacatcata gttacaatga catctctagg 18240 attgaggatt ttgtaagtca aaggtcagct gcttaaaaaa cccataattt taaaaggaag 18300 gatattaata ataactgcat tattgaacat agatagcatt ttgaactttt aagaaatcct 18360 catgggaaaa ctcaggaaat aatctgtttg gtaagttatc actcataatc ttaaattgtt 18420 aggtgcatgt ttgcactttc catgatttga agaggaatat aaagcaaagt tgaattttaa 18480 cctcttccct aatgatttta ctcagctttt caaaggggtc ctaaaagctc agaggtcaag 18540 tcatttcttg gtttgctcta cctgacaaat tgcattaact ctgctttata gccacttgca 18600 gtttaataaa tgacttggac tttgattaat atctttagtg cttaagccca agaatttgta 18660 taagactttg ggatatagta ctgtaaattt atctaaagat ggacactgga aggtagaagg 18720 agatatatta gtgttggttt gggtacatgt ctaggtactg aatttggatc atcataagtc 18780 cttacagaag atacttgttg acttgtcttt taaaaaatat gtgaaagtga ttttttaata 18840 tatttacaaa gtgatctaag tgatttaagg aattcattca tgaagtggat atgactagtt 18900 cttgtttagt attcagaatg actgtaaaat agaaatgctg attttccttg cccagattgt 18960 agaacacaga tcaaaccctc ctagtccttc ccttaaatgt tttttctcca tacagcttat 19020 gccctgagtt ctcaaaacat tttttatatt gaactggact gtatagtata tgcctgaccc 19080 tgattcatgg gattatgctg caagggaata taaagatgaa tattgatagc ctgagtgtga 19140 aaattcatca ttactctcat cctcattcat taattcattt gttcattaac tcataaacac 19200 actaattgat tcaacagata tttattgaac gtttacactt tgcccagtgg agcactggac 19260 taggtgctag catagtataa taagcaaccc agaaatagcc tctgccttgc tgcatttcat 19320 agtctaggac ggagaaaggc attaaccaag tataatttaa aattgtttta agtaatgtga 19380 aataaacata tatgagaact tgactcaggt tggtatattt gatggttagg gaaagcttca 19440 aaaatgggat atttgagatc taagtaagag ggaaaagaaa gagcataatg ggtagagaaa 19500 aaataggatc caggaagata cttagtactt ctgagaacta aaaacagtca agtcagtgta 19560 gtcagagttc aaagaaggag aaagaacatg atccaagaag aagccagaaa agtaagcagg 19620 gactacatct tacacgatga tgtaggctgt attttagttt ttacttatct taagagcaat 19680 agaaaaccat tgaagggttt gaagcagggg agtgacataa tcaggtctgc attttaagga 19740 ggtcacctgc tctattatga agcatgaatg gaggaggatg gaaagagata ttcagggagc 19800 tggtttatga gtctgttgta ggccagaggt attggtagct tggaccaggg tgatgatgct 19860 gaagattgaa aggagttaat agatttataa tatatttgtg aagtaaagtt gactgtactt 19920 agtgctgact tagatagtac tggtgaggga tgtcatggta aactccaagg tactgggctt 19980 cttcaactga gtggaaaaca ctagagggag accaggtaaa ggttgaagga aagtgaggaa 20040 cagtagttca gtttggggat attttgattt ggaggccttt ttaagacttc ctcaaagaga 20100 cacagtgcag tcttgagtcc tggatcagag gagatacctc aatgtataaa tttgtaagac 20160 aatggtttat acacactatt aaagccactg aggtaagtga gatcatgtac agagtgaaaa 20220 tgaagtgaga gaagaaagca taagtctgag ccatgagaac tccaacattt aaaggccaag 20280 tggaaaagtt gacaagagtg ggaattgtga ctggggtaga tgctagaggg gcatctcaga 20340 ggccaaggaa agagaatcat ttaaggtgct gatgaggggt aaagtaagaa ggtcctgtaa 20400 atgtcctctt ggattaataa atttgatgtt ttgaaggact ttagggagaa tgagtttgtt 20460 gtagtgatgg gggcagaagc cagaatgaag tgtcatggga aatgggtgga agtcttgaaa 20520 gagagacaat gaatatagat aactcaagat atgtggtcaa gggaaacaaa aaggataagg 20580 ctttaactag aggaggaaat ggagttaaag gaggagtttt tttttttttg agacggagtc 20640 tcgccatgtc gcccaggctg gagtgcagtg gcacgatctt ggctcactgc aagctccgcc 20700 tcctgggttc acgccattct cctgcctcag cctcctgagt agctgggact acaggtgccc 20760 tccaccacgc ccagctaatt ttttatattt ttagtagaga cggggtttca ccgtgttagc 20820 caggatggtc tcgatctcct gacctcatga ttcgcctgcc ttggcctccc aaagtgctgg 20880 gattacaggt gtgagccacc actcccagcc aggaggagta ttttttaaag atgggagact 20940 tgagcacatt tgaacaataa tggggaagac cagtggggag gatcaggggt ggcctgaaga 21000 tagacagagg gtggataaat aatcatgtag gattcctgag aagatagaag aagttggatc 21060 cagagcacag cagggggaat tagctggcct tggagaggag agatgatctc tatcctctat 21120 tctagaagga agccaaaggt gatgtgtgca gatgcagagg tgtgtttgat gtggtgaagc 21180 caagtcaaag gagtttttgt tcgatgcctt atatctgctc cagaaagcag ttgagtcacc 21240 aactgagaca gggagagaga aaggggctgg catactagga aggaaagggg atcatttcag 21300 atatttgagg aggacagagt aagttggaat atgaaaggga ataaatgagt gaaatttagt 21360 aggactgcta gtcactgctt gaaggctcag ctgaggctga tgatcatgaa ttcatggtac 21420 tactgttaga attattataa aatatatgag cctttttgga ggtgctcagc agtttaccag 21480 acacagaaaa acaggttcat ctaggcttag gattttgtca gagaggtatg atgaaaagat 21540 tgcaaaggag tttaggatat tggcatgggc aagggagctt ctggagtgat aaaccaggaa 21600 tctaagcctg ctagggaggg acatatagac aggagaagga gagtatagag atctttctga 21660 aggttagagg aaatttgtaa tcaaagtggt tgattaaaca agacagaagt atagcagtca 21720 gtgatcagcc caggatgctg caccccagat caattaaatc tgtatttctg ggtgtagggc 21780 ccatcccagt ttctcaggag attccagtgc tttccttaag ggagaatatt gatataactg 21840 ttattaagac tattgtgaaa aaacatatta gcaatgtgaa atcaagacaa aaacacaaac 21900 acagaaagaa gttagacaaa aacaaaaaac actgaaatta cacattttct ttttcacaaa 21960 tcaaagtcaa attcacggac cttcttccct gactcattct ccctgacatt agaagtccaa 22020 agggagcaag taaagtcttt atggggaaga tggtataatt aagcaccaat tacctaggga 22080 ccagatgctt tgggatttga ctgatgaaaa cagattagaa gcatggtgaa tttgttcact 22140 actgtctttt tggaggggca acactcctgg ctcacttggc atgaggtaat gtcagtctgg 22200 ctacaaagat ttgaatgtgg ggcttgagtt tctaaaaggg gactgattgg acttctctta 22260 gccaggatac ttggacttgg tggctatatc atggctcaca gtgtcttgga atggtcttga 22320 gcctagttga aatttgttga aattacatat gaatattcat taatgtatta cttggaactc 22380 agtgagaagg atcatcactg ccagatttcc tagttaggaa aacttacctt cattccttcc 22440 agttaaatag aagaccattg tatagttcat tttgggctaa gtggagtgtt tatgaaatgt 22500 gtagggctta taggcataac tattgctaaa gaaagcccag taaagcttga catcccctct 22560 gttgcccttg tctgtcattc cataaattta atgtcaaggg catttttaga gaagatgatc 22620 acaggatgat tcaggtagac atggagcagg ttgtgaaaac actggcatgt ttcaccaatg 22680 tattagggtt tccagagaaa caggaccagt agggtgtgtg tgtgtgtgtg tgtagattta 22740 ttttaagaga ttggctcaca caattatgga gactcgcaag ttcaaaatgt gcaaagtggg 22800 ctagtaggtt ggagacccag agaagagctc atgttgcaag tcaagtccaa gtccgctgca 22860 gaatttccct ttgcttggga ggtcagtctt tggctctatt aaggcattca actgattgga 22920 gggcagttta ctttactcag agtacatcat ttaaaatttt aatatcatct aagaacactc 22980 tcatagaaac atttagggta atgtttgaca acatatctgg gcaccatggc ccagccaagg 23040 tgatatagat atagatatag atagatatag atatagatat agatatagat atagacatag 23100 acatagatag atatagatat agatatagat aatggatata tataatggat atataatggt 23160 tatataatta aacattacac ctgggaagtt acagcactat cttctctgga ttaaacaaca 23220 acaacaaaaa tactcagtcc aattcatgat ttgttgaggg tctgtgtaga atatagaaat 23280 tatactacaa gtttggtttt ctttaggatg gtgagcattt tataaaatat gtatatataa 23340 agagaggcat tctcttgtaa cacttagaat agtcctgtac acatagaagg cacacagaat 23400 gtccagtgcc agtgacatga gacttcataa tgagtttgaa gccaaagctt tgtgtagtaa 23460 aaagccatga gcagttaata aatttccatt tgatggcagc tataaatatt aaccagaaga 23520 ctcataactg tgttttcaac tcacatacct gggttggggc agaagcaata gtttcagcag 23580 cttttattta tctgctttta attccatctc accattgtta aatttacctg aaataattgc 23640 cattttgaca atgccctcaa aaatcatctt attgcctggg gactgatttt cagattcctg 23700 agcccagtat tcagaatcct atatattccc tcaacctatc tttccatgtg tattttctgt 23760 tgagcttcaa actgaactac ctctttgctc tcaacatatt ctatttgtta acttttgttc 23820 atgttattcc ctctaaaatg acttttctct aatttttttc attctctcat tcttcttgtc 23880 tttcgaggtg gaactcaaat gccacaacgt caaatgccac agtatctgct atgatccttc 23940 ccctttccag ctacaaattc ctctttcctc taccacttct ttggcacatt tattaagact 24000 cgcgatttct ctcatctaag tctcttgtgc aatgtcttac tgtatgtggc ctgaattcag 24060 gatctatgtc tacagcctcc cctttagcct cactccagta tcttgcaggt gggcagtcct 24120 ctgtaaacac ttgttaaaaa agtcaaaaca catttttcaa atcagaaaga acctaacata 24180 caaagcctca ttgtcatttt taaatttcat cgaagagcta tacattgaat tttttgtgtg 24240 ttctctatag tacctagcca tgtgctggac agtggaccca cagtggacat tcagtaatta 24300 gtaatagatg gatttattct gtatttaaca aaattttctg gatgctttta gactgaagga 24360 gattggtttg atgacacaag tttcaaaaga caatgttatt gctaatgcac attatgaggg 24420 aactatgata tattttgaag tccaacaaat agaaaaatga atcaatcacg agtcagattt 24480 attgatggaa ttgtgccacc atcaagtcct aaagcattag tagtgatgtt atcagaaaat 24540 atcccactct gagatcatct gtagccagct ttatactcta aaagaatagt ctgagtatgt 24600 tctgcctgga aaagggctca gtggtctagg aattattgtt tttacttttt caaagtttat 24660 aaacttggca tgactgtgct tttctgtggc ttccaatctc tggtgataag ttttctcaaa 24720 atattcctga tttatcctga tgtaaatcac aattcataaa tatcaagaga gactgcctac 24780 agtaccatct tctgatttaa aaacacattt gaatcaatat ttacttatat ataatgcatt 24840 ctgctgaata aggaagttct gacttgttaa gctcagtatg cttcgataag aaagcaaaat 24900 ttttttgttg ggtttttaaa atgtatttta aggtccttgt ctcttggtga tagttcttta 24960 catattgaag tgccagggaa taactgtcca gtagctggac aagagagact cataatatgg 25020 cagttgaagc caaagcatta agcaaaaaca gttattaata ttaacaggct cactgtagag 25080 agaagccata gttgtcaggg gaggcagaac tgcccaggaa acccatcttt gtccttttgt 25140 ctacacaggt tggggcaaaa gcagcagtta tttgaactca gcaaacctgt gttccatatt 25200 gaaggcctgc ataagtcagg gaccagggat gtaatgaaga ccagacatgg actttaggag 25260 cacaaagtgt agagataaaa ctgcactcat aatgtaagct aatgggaggc aggaacgatg 25320 gaagcagcaa agactcgcta cagtgggagg agttatgaga gacttcccag aagatatggc 25380 atctgagctg attcttaaaa gttctgtaag aggccaacag gcagagaaaa aatgaaaaaa 25440 tgctattaaa cagtatagcc cataaccgtg gggatatacc agaggatgat gtgttaggga 25500 aatggtaagt actttaaagt ggctagatca gagaatgttc gagggcaggt gaagggaaaa 25560 gtaggcaggg ttcttatatt tatatcagtg atcttggact ttgtctgggg acctgcaggt 25620 agctgctacc agaatttctt atgtcagtaa gtaacatgat cagatttgtt attttagcaa 25680 gacaacttac actataaagt atagagaggt gtttggagtg cactgattga acagtagtgt 25740 ggagatgtgt tttttaataa taaaccaaat gagtaataac atgtcttact cttacataat 25800 tagtaagatc ttgccagcat ctttgttgga tgaaaggaag cctagtgttt atcaccaaat 25860 cttttgagat gtcagtataa cacaacactg tattccactt ttgaaaacag ccatccctat 25920 agtgtgtgaa gagaatactt aaagtgcaga cagacaagtg aacaccgcac ttctttgtca 25980 catgcagtca agaaaccaga caagatattt aagctatgat tattagtgtt ggcaagggtt 26040 cagctccagg gaaaataaat acattgagtt agtggtggtg atgagattga cacgaataga 26100 gttgtatttt ccttttcatg ctgttgcaag ggaaatgaag ctttaaacat aatgaaattg 26160 gttcttgtga acagcaaatc tgctatttct tcacttttta tggctttgtc aacagtgatc 26220 taagttttgc tttacttatt tattttaaat tttgttttat tttaatagtt tttggggaag 26280 aggtggtttt tggttccacg aataagttct ttagcggtga tgtctaagat tgtggtgcac 26340 ccatcaccca agcagtatac actgtaccca gtgtgtagtc ttttatcctt caccccctcc 26400 cacccttctc cctgagttgc caaagtctat tatattattc ttatgacttt gcatcctcag 26460 agcttagttc ccacttacaa gtgagaacat acaatatttg gttttccatt cctgagttac 26520 tttcagctcc atccgggttg ctgcaaatgc cattattttg ttcgttttta tggctgagta 26580 gtattccatg gtatatatat atcacatttt ctttatccac tcattggttg ataggcattt 26640 aggcttgttc catatttttg caatggcaaa ctgtgctgct gtacaaatgc atgtgcaagt 26700 tgtgcaactg cctccctccc tccatctctc tctctttcct ttcttccttc cttccttctt 26760 ttcttctttc cttgttttct ccctccctcc ctccctccct ctatctctcc ctccctccct 26820 ccctctctct ctctttcttt ctttcctttc tttctttctt ttctttctct ctctctcttt 26880 ctttcctctt tctctagccc tgccacccag gctggagtgt ggtgccatga tctcagctca 26940 ctgcaacgtc caacctctgc ctcccaggtt caagcaattc tcctgtctca gcctctggga 27000 ttacaggtgc ccacaaccat gcctagctac tttttctatc tttagtagag atggggtttc 27060 atcatgttgg cctggctggt ctcaaactcc tgacctccag tgatccaccc acctcagtct 27120 cccaaagtgt tgggattaca agcatgagtc accatgcccc gcacaagtgt ctttttcata 27180 taatgacttc ttttccttcg agtagatacc cagtagtggg attgctgaat cgaatggtat 27240 ttctactttt agttctttaa ggaatctccc tactgttttc catagcggct gtactagttt 27300 acattcccac cagtagcgta aaagggttcc cttttcacta ccttcatgcc aacatctatt 27360 atttttttat tttttaataa tggccattct tgcaggtgta aggtgatatc acattgtggt 27420 tttaatttgc attttcctga taattagtga tgtcaagcat ttttttccat gtttgttggg 27480 cattcgtata tcttcttttg agaattgtct attcatgtcc tttgcccact ttttgatggg 27540 attatttgtt tttttcttgc taatttgttt gagttccttg tagattctgg atatcttgcc 27600 gattctggat attagtactt tgtcagatgc atagtttgcg aagattttct cccaatcggt 27660 gggttatctg tttactatta ttattattat tattattatt attattatta ttattgctgt 27720 gcagaagctt tttaattaat taggtccaat ttgtttattt ttatttttgt tgcatttgct 27780 ttggggtttt tgctcatgag ttctttgcct aagccaatgt tgagaagagt ttttttgatg 27840 ttatcttcta gaattttaat gatttcaggt tctagattta catctttggt ccatcctgaa 27900 ttgattttta tataaggtga gggatgagga tccagtttca tccttctaca tggggcttgc 27960 caattatccc agcaccattt gttgactagg gtgtcctttc cccacttcat gtttttgttt 28020 gctttgttga agatcagttg gctgtaagca tttgccttta tttctgggtt ctctattctg 28080 ttccattggc ctatgtgact atttttatac cagtgccatg ctgttttggt gaatatggcc 28140 ttatagtgta gtttgaaatc aggtagtgtg atgcctccag atttgttctt tttgcttagt 28200 cttgttttgg ctatgtgggc tcttttttgg ttccatataa attttatgat ttttgttcca 28260 gttctgtgaa gaatgatgat ggtattttga tgggaattgc attaaatttg tagattgctt 28320 ttggcagtat gttcattttc acaatattga ttctacccat ccacaagtgt gggatgtgtt 28380 tccatttgtt tgtgtcatct attatttctt tcagcaatat tttgtagttt tccttgtaga 28440 gatctttcaa ctccttcgtt aagtatattc ctaagtattt tatttttatt tttgcagctg 28500 ttgtaaaagg aattgagttc ttgatttgac tctcagcttg gtcattgttg gtgtatagca 28560 atgctactga tttgtgtaca ttgatttttg atcctgaaac tttactgaat tcatttatca 28620 gatctaggag ctttttggag gagtctttag gattttctag gtatacaatc atgtcattgg 28680 tgaacagtga cagttggact tcctcttttc tgatttggat gcctttattt ctttctcttg 28740 tctaatcact ctggctagga cttctagaac tacgctgaat agaagtggtg acagtgggca 28800 tgcttgtctt gttccagttc tcaggcagaa tgctttcaac ttttccctat tcagtacaat 28860 gtgggtttct cctagatggt ttttattact ttgagttatg tcccttctat gccaattttg 28920 ttgagggttt ttatcataaa agtatgctgg attttgtcaa atgctttttc tgtgtctagt 28980 gagatgatca tatgattttt gtttttaatt ctgtttatgt ggtgtatcac atttattgac 29040 tcgggtatgg taaacctaca tccctggtat gaaaccacta tatccctagt atgaaacccg 29100 cttgatcatg atgtgttatc ttttttgaaa tgctgctgga ttcagttagc tactactttg 29160 ttgaggattt ttgcatgtat gttcattagg gatatttgta cttttagttt tctgttatgt 29220 cctttccaag tttaggtatt agggtgatac tggcttcata gaatgatttc ctctttttct 29280 atctttttga atagtttcag tatccaattc ttctttaaat gtcagataga attcagctgt 29340 gaatccatcg ctcttggact ttttttgttg gcacttgttt ttttattact gtttcagtct 29400 cactacttgt tattggtctg tccagagttc ctgtttcttc ctgatttaat gtaggagggt 29460 tgtatatttg caggaatttg tccatctcct ctagattttc tagtttgtgt gcatataggt 29520 gtttataata gccttgaatg atcttttgta tttctgtgat atcggttgca atatctcgtt 29580 tcatttctta ttgagcgtat tcggatcttc tctcttcttg gttaatttca ctaatggttt 29640 ttcaatcaat tttatttata ttttcaaaga accagctttt tgtttcactt gtcttttgca 29700 tttttgttgt tgttgttgtt gtttcagttt catttagttc ttctcttatt tggttatatc 29760 ttttcttctg ctttgtttgg gtttgttttt ttcttgtttc cctagttcct tgaggtgtga 29820 ccttagattg tctatttgtg ctctttcaga ctttttgatt taggcattta aaactatgaa 29880 atttcctctt agcatcactt ttgttgtatc ccataggttt tgataagttt tgtcatcatt 29940 atcattttga aagaattttt aattttcatc ttgatttcat tgttgaccca aagatcattc 30000 aagagcagat tatttaatgt ccatgtattt ctatagtttt gaaggtttct tttggagtta 30060 attttcattt ttattccgca gttgtctgag aggatactta atatgatttt gtttttctta 30120 aatttattga gactcgttta gtggcctatc atatggtctg tcttggagaa tgttccatgt 30180 gctgatgaaa agaatgtata ttctacattt ttaggtagac tgttctgtaa gtacctatta 30240 agtcaatttg ttccagggca tagtttaagc ccattgtttc tttgttgact ttctgtcttg 30300 atgacatgtc tagtgttgtc aatggagtac tgaaatccca cactattatt atgttactgt 30360 ctatcttgtt tcttaggtct agcagtaatt gttttattaa tttgggagct ccactgttag 30420 atgcatatat atttatgatt gtgatatttt cctgttggac taatcctttt atcattatat 30480 aatgtccctc tttgtctttt tttttttcca ctgttgttgc tttaaagtct gttttgtctg 30540 atataagaat agctactcct agactggccg cagtggctca cacctgtaat cccagcactt 30600 tgggaggcca agatgggcag atcacaaggt caggagttct actaaaaata caaagaaatt 30660 agccaggtgt ggtggtgtgc gcctgcagtc ccagctactc aagaggctgt ggcaggagag 30720 tcacttgaac ccaggaggtg gaggtcatag tgagccaaga ttgcaccact gactccagct 30780 tgggcaacag agcaagactc tgtcaaaaaa aaaaaaaaaa acctactcct gctcactttt 30840 agtttccatt tgtgtgaaat atctttttcc acttctttac cttaagttta tgtgagtcct 30900 tatgtgttac gtgggtctct tgacaacagc ggatacttgg ttgtcggatt tctctccatt 30960 ctgtcattct gtatctttta agtggagcat ttaggccatt tgctttcaat gttagtattg 31020 acatataagg tactgttcta ttcattatgt tagctgttgc ctaatacttt ttaaaattat 31080 gttattgctt tataggccct gtgagattta tgctttaaga aggttctgtt tgggtgtatt 31140 tcaaggtttt gtttcaagat ttagaacacc cttaagcagt tcttgtagtg ctgatttggt 31200 agtggcaaat tccctcaaca tttgttagtc tgaaaaagac tatctctcct tcatatctga 31260 agcttagttt tgctggatgc aaaatttttg actgacaatt attttgttta agggggctaa 31320 agataggacc ctgctccctt ctgattggca aggtttctct tgagaagtct gctgttaatc 31380 tgataggttt ttctttatag gttacctgat gcttttgtct cacagctctt gattttttcc 31440 tttgtcttga ctttagataa actgatgact gagtgtctag gtgattatct ttgcaatgaa 31500 ttttccagga gttctttgag cttcctgtat ttggatatct aggtctccag caaggccagg 31560 gaagttttcc ttaattattc ccttaaataa gtttttctaa tttttagatt tcacttcttc 31620 ctcaggaaca ccatttattc ttaggtttga ctgtttaata tagtcccaaa tttcgtggaa 31680 actttgttca tttttaaaaa ttcttttttc tttgtctgat tgggttaatt caaaagtctt 31740 atctttgagc tctgaagttc tttcttcttc ttgttctagt ttgttgctga aactttccac 31800 tgaattttat atttccctaa gtgtatcttt catttccaga agttgtggat gtttttcttt 31860 atgatatcta tttctctgga gaaaatttcg ttcatatttt gtactagttt ttaaatttat 31920 ttaaattgtt ttttgccttt ttctggtaac tccttgagta gcttaataat tgaccttctg 31980 aattctttgt ctggaaattc agagatttct tcctggttcg gatccattgt tgtggaacta 32040 cagtaatctt tgggggtttt atagaactct gttttgtgat attaccagaa ttacttttct 32100 ggttccttct catttgggta gactattact taaaattgtt tttgtggact gtgttttttt 32160 tttaatttct tattttttct ttcttaagaa tcagactcta atgtttattt tagcctaatt 32220 ggagtcttgg tgcttgtagg ggtgaagact ctgtacgaga tccttagtta cagaatcttc 32280 ctgcactggt tttccccaat gctgatttta gtagttacat acttggtgtg tgggtgaatt 32340 ctctgtctcc tgtgaagctg gaatggcagg gatcccttga cgcttatgtc ctcctctcat 32400 ggtatacagt ttatttactg gtcttttatt tactgagttg atgattcagg cttcaggaca 32460 attggggagg tatcccccgg caggcaccag ttgtggctaa ggcaagtggg tagatgtaat 32520 acccaatggc gagccgaggt cacagccttg atgagggtgg ctggaggagc tctcaattag 32580 gtgtgctgaa attttatcaa ggtgaaaagt gggagcttcc tcagctcccc tgccaagtca 32640 gaaagaaaac tattcacctc acagcctcac tcctgtccta gcatttcagc tattcagatc 32700 agacaggcat ctcttttcat ctataggaat gttgttgttc caagtaggga ggaactgtga 32760 ctctgcctct catgcaggcc tgaatctggg gtttgctcct cttgtgggcg atactcaccc 32820 tggagtgttc cagaaaggct gtctacaggt gtatccatgt gtgttcctgt gggggaagcc 32880 ccagctgtgt ctgcagtgga gtgccagggg gaacaaggac tccttttcca aggcccttca 32940 tggtcacaga ggctgcttgc ctattggggt ataggtgcag actttcccta ctgcacctgg 33000 cactgcaatt gggtctctgc tgtgagaaac tacccactag cagaaagatc tgaaactcct 33060 actattcaga ttattttgtc tcacttagtg attccttgat gtggtgttct cctctttccc 33120 ctagggatgg gcttcctgag agccagattg cagtgactgt tattgttctt ctgggtctag 33180 ccacccaatg gagttaccag gctctgggct ggtgctggcg aatgtctgca aagagaccgg 33240 tgatctgatc agtcttcagg tctcctagcc atgtatacca gcacctgctc tggtggaggt 33300 gacaggatag ggatgtagac tctgtgagaa tccctgattg tagataggtg tagtgtgctg 33360 gctttctcaa atgctagtta tgctagtatt gaagttgcca cgtggacaga ctaaggacct 33420 ctggttagcc aggatgttgc aggcagtgat attagctgtt gttttctcct tcctgggagc 33480 aatattattg tcatgagtat ggcctgagtt ggttggcctc cagccaggag gtggtgtctt 33540 ttgtgttcgg ctgccaaggc agatagaaaa ataccatcaa gtgggggcag gattaggcgg 33600 gtctgagctg agactcttct tgggctagtc ttgccacagc cactatgtag gatggggagg 33660 atggttttca ggctgatggg gttatgttcc agaggggatt atggctgcct ctgtggcaca 33720 gaatagttca ccagggaagt ggagaatagc cagtagtgaa aggcttcacc cagctcccac 33780 acagttggtg agcccaatct cactcttgca atgctgtgtt aacagcacca agtttagatc 33840 cacgcctcct gcttgtggaa ctcagtctta ctccaggcca tacacttccc cactgagaaa 33900 gcaagcaagg ctttcaggcc acacccctcc ctgtctgccc acaaggttcc tgtgctcata 33960 tctgctgcag ttcccattca cccaccagat tctgttcacg caggttcatg ccccctcaaa 34020 attatcacaa aattcatttg gaagcttctt tcaccttgtg ccccctccct aattctgctg 34080 gctgccttcc ctgagggccc ctgtgagata tagtcaggca tggcttccct gggtttgagc 34140 tggagactgg gagtgcctac aagactcttc ctgctgctgc ttctactttt gtgtttcacg 34200 tggctcccta aatctgttcc agctctaggt aaggttaaat ccttctctca tgatctggat 34260 tttcagattc cccagtgagg atatgtgttt ggaggcaggt tttcccccat tcacactttg 34320 ggaactcatt gctttttgcc tgtctcacag agtttgcagc agcctgtcac ttctttcaaa 34380 ggatctgtga attctttcca ttttcctgat atgatcctgt ggtggttctt ggaaaaaagg 34440 ttcacagtct gagtctccac acactgttct gtccatccaa gcaggagatg tatgttagcc 34500 ctgcctgcta tctgccatct ttcttctgtc cccaatcctt ctctttagat agctgagata 34560 ccatcttttg tttcttctga cttggttcta ttcactgaca ttcctctcta tcaagtagat 34620 ttttgaactt tcatggaaat ttattcccaa tttatatgga aataattccc aatttatatg 34680 aaaagcttat aaagtgattc attaaccaag tatttactga ggtgctaaaa gtatactctg 34740 aagcaggagt ggcaagtcct ttgccttcat ggagattgca ttctcttgta aatcttacat 34800 gatggtcact agatttagga ataaaggact ccagcataaa acactgacac ttctgctgga 34860 gaaatatttt acaaactata tatattgaag cccaaactct ggtttattgg taaaggagta 34920 gcactgatac tagaattttg tgatcaacat gttggaataa gaagtcagaa gacttagatc 34980 tgtgttcttt ttctcccgct ggctataggt tgctttaatc tctgagctgc agtttcctca 35040 tctacagaat aggttagacc agattagtgg tcttcaactt tggctgtata ttagaattat 35100 cttactcttg accaattagg ttagaaattt cgggccacac acaatggctt acgcctgtaa 35160 tcccagcatt ttgggaggca gatacgggca gatcacaagg tcaagagatg gagaacatcc 35220 tggccaagat ggtgaaaccc catctctact aaaaatacaa aaattagctg ggtgtggtgg 35280 tacacacctg tagtcccagc tactcaggag gctgaggcag gagaatcgct tgaacctggg 35340 aggcggaggt ggcagtgagc cgagatcgtg ccactgcact gcagcctggt gacagagcga 35400 gactccgtct caaaataaat aaataaataa aaattaaaat tagaaatttc ctggtggaga 35460 ggaaagcaga ggtattttta aagctctcag gtgatatatt tctgttttaa ggtaggacta 35520 aaaatcatgg gactacgtca gaagttctaa ttataaatct ataggttagt tttctccagg 35580 catgggtata gtgcttaaat gccttttaaa tttgttacca acatagaaaa aaaaaggttt 35640 ccggcttctc ttgaaaaatg gaaatattag gcaacagttg ggcttatgtt tctgagtggt 35700 aaaaattaaa caaagtaaac gagtctccgt ttcatttgtt cctgttgcct tcctggctct 35760 tgaaggcatt gtcatttgtg aaaactaaac tagatggtct ttaaaatctc caattatttg 35820 aattgcttat ttccacatcc agaaaagaga cggtaaacaa actatacctt tatctgtaag 35880 ctagttggtt tgtgaaatca aagggaactt aatctttgaa tatggaaaaa tcccagggtc 35940 caatggaaga gaaactccat ctcattaata gcaggactcc acagactgct atggaaaaga 36000 cacccacccg gggctaagag ggagggaggc ggaagaggac ttaattcatt ttctgggcat 36060 ttttaatgaa gctttcccct ctttcattat ttcttatttg ggagctggat cattagttgg 36120 gatgtgactg gctttccctg gggagcaaaa aggagattaa cagaggtttt gctcgcttct 36180 tcctgtgatt tactgtggga agtctcccag gttcttccct tcgcttctct gtggccttca 36240 tcttcatggt ttcttgctgt gtctctctga gagcaagtac ctgggtgaaa aaggctgagt 36300 gtgtggtttt ttggcaactg cctggcattg gatttaagtg ggtatatttg aattactaga 36360 attttacatt ttataggttc aaaatatgca cttgaattct gtaggacctc ttacccaaat 36420 tgaataatcc tttgtgcctt gttaaatttt aaaaagtcac actatcaaca ttatgacata 36480 tggcatatat gatggcaata ataaaaataa cacacttatt gtccacttta atgtgccagc 36540 agtgttccaa gtgatttgcg taaatatcaa atttgttcca cacaattatc ctatgaacta 36600 aatgttatta tttcctggtt tataggtgag gaacacagag gctcaaagca gctatttgat 36660 ttctcttatt tcaaaattag gggaagtgag atacattaac ctgtataacc agaccttgtt 36720 aactgttttt ggtaaattcc aatgtgtatt gattttcaca aagacaaatc acaccattgt 36780 tatattaaat attaattttt tcatagtccc tcaaggtgct tactggctat attgttactg 36840 tcttttgatg ttgtttatac atggtggatt acagaattcc atgaacataa aaaatcttga 36900 ctttatccta gcctatttcc tattcttacc ccctgcaaag taaaaagttc aaaatagcgt 36960 tagtaagcca agcaaactac ttactagcca catgaaccta ctagcctctc tgcctcagtt 37020 tctttgttgg gaaaatggac aatacctaac tcaactcata aggatatttc tagaatcagg 37080 tgtaatatca aataaaaata tatttccttt ttcctagaag atacccatgt atatcttagg 37140 tactgatgta ttcatagtga tgcagaacat aaaatgttta ttcttttgct tagcaacaac 37200 tatccataga gatttttcca ctttagagat ttaatcccat taaaggtttt tagattgatt 37260 ggacaatgag aatgtttttg tctctctgaa actgaggctg aaagttgatt tcattctctc 37320 acttcaaatc atactacaag gctacagtaa ccaaaacagc atgtcactgg cacaaaaaca 37380 gacacataga caaatggaac agattagaga gcccagaaat aatgccacac acctacaaca 37440 atctgatctt tgataaagtt gacaaaaaca agaaatgggg aaaggactct ctattcaata 37500 aatggggctg ggaagctagc tagccatatg cagaagattg aagctggacc cctccttaca 37560 ccatataaaa aaatcaactt gagatagatt aaaaacttaa atgtaaaacc taaaactata 37620 aaaaaccctg gaagataacc taggaaatgg cattctcgac ataggacctg gcaaagattc 37680 catgacaaag atgtcatgac aaagatgtca aaagcaattg caacaaaagc aaaaattgag 37740 aaatggaaac agattaaact aaagagcttc tgcacagcaa aagaactatc aacagagtaa 37800 acagcctaca ggatgggaga aaatatttgc aaactataca tccgacaaaa gtctggtatt 37860 cagaatctat aacaaacttg aacaaatcaa caagcaaaaa acaacccaat taaaaagtga 37920 gcaaaggaca ttaacagaca tttttcaaag gaagacatac atgtggccaa caagcatatg 37980 aaaaaatgct caatatcact aatcattatg gaaatgcaaa tcaaaaccac aatgagatac 38040 catctcacaa gtcagaatgg ctattaccaa aaagtaaaag aaaaacagat gcctgtgagg 38100 ttgtagagaa aagggaatgc ttatacactg aaaagggaat gcttatacac tgctggtggg 38160 aatgtaaatt agttcagcaa ttgtggtaag cagtttggta atttctcaaa gaactcaaag 38220 tagaattacc attagaccca ataatcccat tattggatat aaacccaaag gaatataaat 38280 cgttttacca taaagacaca tgcatatgta ttttcactgt ggcactataa cagagacaca 38340 ataacaaaga catggaacca aactaaatgt ccttcaatag tagactggat aaagaaaatg 38400 tgatacatat ataccatgga ataccatgca gccataaaaa gaaatgagat catgtccttt 38460 gcagcaacat ggatgaagct ggaggccatt atcctaagtg gactaacaca ggaacagaaa 38520 accaaatacc acatgttctc atttataagt ggaagctaaa cattgggtac atatgaacac 38580 aaagaagaga gcaacagaca gtggggccta cttgtgggta gagggaggga agaggatgag 38640 gattaacaaa ctacctatca gatactatgc ttattacctg agtggcaaaa taatctgtac 38700 accaaacccc tctgacatgc catttaccta tgtaacaaac ctgcatagta cccccgaact 38760 taaaagttaa aagaaaaaaa aatgattaat gagcgtgata ccagaacaat attatgatgc 38820 agggctattt tttgtgtgtt tgctagctgg gcttgagatt tgataaataa gtcccattgt 38880 cctaatccgc tagtgatgat gttctagcct ttgaaattca aactactact actccacttt 38940 gagagagact gcatgagaat tggacccagc ctggggcttt agacaccatg gttcaaatct 39000 tggctcttat cattttttag ccacgtgtca tggactcaat gtttttgtct cccagctccc 39060 cagattcaca ggttgaagcc ctaacctcca atgtggctga atttgagatt agggcctgtg 39120 aggagctggt aaaagttaaa tgaattctta aggataggtc tccaatccta tagagttggt 39180 gctcttacaa gaagaggaac agacacccga gttctctctc tttgctatat gaggacatgg 39240 tgaggagtgg ccatctgcaa gctcagaaga gagccctcac caggaactta agtgtctggc 39300 accttgatcg tggacttccc gacctccaga actgtgagaa ataatttttt gttgtttaaa 39360 tcacccaaac tgtagtattt tgttgtggca gcccaagcca attattatac catgtaagca 39420 ggttacttaa atttactaaa tatgtaagtt acttaaaatt tcaaatcctg gttctaactt 39480 tactagctat cacttttact agctaacaca ttacattttc ttcaacttgc cgcatgcttt 39540 tgctgtgagt tttaaatgaa attgcttaag tactttgctt atcatactgc tgatccatag 39600 taagcactta aagttagttt ccaggaagtt tggaatggat ctcacttatg caaatggttg 39660 actttgacgg tgcttgttcc tctctggaaa gggttcacct cccattagaa tagtcctgtg 39720 actgcagtaa ttttgtatgt taaacttaca tgtatatctg cagaatgtta aatctgcaaa 39780 caccatccat caacccaaaa gcaaaaaaag agtgtttcct aatagttaat agttggtagc 39840 ttaataggaa atctagaaaa aaaatgttta ataatgaagg ctatattaat accaagtctc 39900 atttgagttc ctgtcagtaa ggaaatagtt atctttcgtt gttaatcaat gaagaccagt 39960 tgccataatt agggctctgg tgtgttttct tcacatggtc ttctaggacc taatgtaata 40020 tcatttgaga ggctcaaaga ggatcccata ttcccaaagg tatcttagag tccttagctg 40080 cccaacatcc caccattaat catgctttgc agatgaaaaa ttgaagactc cttgtctctg 40140 aatatctggg atatgctttc attcctagga tggacatttt tcttcttccc caataaggaa 40200 gaaaaaggga cagaggtgat ttataagagc agttctactg agtgaaatgt gggtcctagc 40260 aaaggaggac acagctgccc cttgtaatag tggagggaag gaaggaggca ggctggctgt 40320 actttgccct cctcaaccct aaaccctatc tgtttaccac agtggacctt ttttctgaac 40380 tctaacctca ttatttcatt cattatccac gtaatattca ttaatgttct ccaaggctct 40440 tagaataaat ctttaacatt tccccaaaaa gtcacaaggt ctgacacctg ccttcctttt 40500 tccagcttcc tatcataatc ctcctttttg gcagtggcca cactgatctt ctttcaggtt 40560 cccaagctca gcatttgctt ttcattggga gccccttaca tcatgactgt cagcctgatt 40620 gtcatttctt tggggaggcc ttccctgaac cctggaactg gatcatatac ccctatcatg 40680 tgctttcata gcaccatgaa tgtctccttg gtggcagtcc ccagtaggag aattctgtgt 40740 ttatctgtat ggctgtttca taaatgttta tcttcctccc aatagtctgt cagcactttg 40800 gcagccagtt gtgttttgct gttgattcta cctccagcac agaatgtctc ttagtattta 40860 tggaagggga catgaaaaaa gaaaaagtcc actgcatgaa gatttaatcc agcgacactg 40920 aggcctgaac atctagcttt agggaagcca gcttctagca ggacagactg gtagggacta 40980 ggtaaggaga atggaaaaac acagggaatg agcatcactt tctttaagac tttgcctctg 41040 gcagacccct ccaagtaaca gattccaaag agattgtgaa tgttctccct ctggtatgca 41100 gtctcctgtc ctgtcagaaa catggtaccc agaggccaaa gctgctgcat aagcaagtta 41160 tcatgaaact attccaggac aggtttcaga agcagggtct taaaaatgag tattaaatct 41220 aatgttcacc cagatacatt tccaacccac atatagacac cgaatttaac gatgaaagtg 41280 gaagttactc tgttgaggat ttatttgaaa tgttggtttt ctcttgtcca tctgatacag 41340 gtcatagctc tgtttctgtc attagattga ttttcatgtt tctcagcaca gactctctgt 41400 gagtcagaga taagtttaat ttttcagcat ggccatagga atgatgaagt cattcctcat 41460 taaaatgaag ctaagcaaaa tttaatagta cttgtttaag attccttatt tacttttcta 41520 cacaaaaaga gttgcaaggg gaaaacaaaa actttagctt tgagtaattt ccttaattca 41580 aatatagatt taaaccactt tgtcataata tgtaaatgaa ctattgcttt tttcaccaca 41640 ggtctgtttt caaatagata atgagattat ataaataatt accttatata aacataaggt 41700 tactcattat tgaaagcaat tttctttttt tgtttctggt ttattatggt taagagtgag 41760 cctttgtttt agatatttga aaacaaaatg tgtgtgtgcg tgtgcttttg tgtgtgtgtg 41820 tggatatgtg tatctaggga ggtcctcaaa ttcaaaaatt ataatacaag gttgtaatgt 41880 cagcacttcc tattgcatag ttttataatg gggatatata gctatgcatt aaaatgcatt 41940 attgaaatgg aaaatcagga tgtgttaaaa atgaattagt aattatatta agatctgaat 42000 gggaactagc atacaatgta acttaagctt ttgaaaaata aaaaaaaaca gaaaataatt 42060 aatgataagt tagtttcagt attacattga taaatatttc cagaataagc tataaaaaat 42120 aaggaggtag atttattatt ttaaggttca tactaaaaga ttgtaatatt tacttaacct 42180 ttctttattt aatttagaat aagattactg tcatctctct aagcatctat gtaatagtgt 42240 tttatttact tttccattaa atattactga gataaataag gagtcctggt gaatgaaata 42300 taatttaata agcagagttt tcttaggtga aaactaatca tgtcctgcta taaatgtata 42360 ttgagagaga agctgaatag acaagctcca tgatttagtc aatgatacga cttcagggaa 42420 aatgttttta tgccttgttg gccatatctt ttaatacttg cattgaaaat aaaattacat 42480 cccaagatta tgagggttgt gaaattttat aattagatat ttaagtcctg aattgattag 42540 cagcagtata aacatagaca tggattttgg gttaaatctg agaactattt ttttgtacta 42600 aaatttgcgt gcagatgaca atgggaaaat caaatgtttt cctggaaaat tttcaaatgg 42660 gacaaatagt catctttctg gaaatatgaa ataaagggag tggtagtggt tggactataa 42720 acctctttga aggcctttta atctttagct gtaattcatg ttttatcacc attggatttt 42780 caaaacggaa aataccttag aaataattta gtgggccggg cgcggtggct cacgcctgta 42840 atcccagcac tttgggaggc cgaggcgggt ggatcacgag gtcaggagat cgagaccatc 42900 ccggctaaaa cggtgaaacc ccgtctctac taaaaataca aaaaattagc cgggcgtagt 42960 ggtgggcgcc tgtagtccca gctacttggg aggctgaggc aggagaatgg cgtgaacccg 43020 agaggcggag cttgcagtga gccgagatcc cgccactgca ctccagcctg ggcgacagag 43080 cgagactccg tctcaaaaaa aaaaaaaaaa aaaaaaaaga aaaagaaata atttagtgtt 43140 accttgttga tattaccaaa aaaaaaaaaa aagtgctcag agtcacataa cttgattcag 43200 tcagagctgg tactagatgc tcagtcttct gacttctaat ttagtttgct ttcattatct 43260 acttactacc tgctgctgac tcagagctcc tcagctatct gcaagtggat gtgtttattg 43320 aacatttacg atgtacatga actgctctca atgcgaagct cccatggtga atgggagctt 43380 actttctgac tcaaaaatta gttttctctc tttgtgttct aaatgaaagt gtccttttgc 43440 tttatctgaa gcagaaagtt gtaagtttgt ttattttact tttgaaattt tggagaattg 43500 gcagtggggt catgccatca gaaacacata catgcaatgc atggatgcac ggtgtgaatg 43560 agctctctgg aagatggtag attatgggaa agaaggaagc tcagaaagag agtggaccaa 43620 gtcaagagga aagagagaag aaacaggcaa gtgtggagca gaggaaaagt aggagggtca 43680 tgaatccatt ctgcaggtgt gtgctgagtg actggaagaa ggaaaagaac caaggaagtc 43740 tctgccatgt tatcttagtt ttgttaaggg tataaagaga ttgaagagag tttaactagg 43800 ccatctttaa ccctaggaca tccctagagt ccctggcaga actaataatc taaattatga 43860 atggctgtgt gtgcacacac acaggatgca cttactaatg tctatcatta tgagtatctt 43920 ctgacttctc cactacaaag aaaggaaggg aatgtgaccc tctttccagg ttagaagtaa 43980 ctagggcata gtaacacaaa tggatgaatt aaactgttta aatggtgcac tggaatatat 44040 ttattttggg gcaaatcatg aagaaataaa aaaggaagag attctctttt gagaaaaagt 44100 ttgtttccta ttgtcaattg agcaactctg tgaacatctt aaagataaag aatgattatt 44160 ctgtaaagtg ctgggatttc tggtgctgtg tgacaaagtc cggttccttt tgtctaagtt 44220 agttataata atctttaatg aaaagcagag gggtcccatg gtttggaaca agtatctgag 44280 tcaagagttg acaagtagaa tagctgggcg cagaggctgc tgtcaagttg acaaagccag 44340 aacagtacat ttggacagaa agaatttgat tttcttatac tgaatgtgat gatcttgaag 44400 aacagatttt ttttttgcat gaaaataaat ctttattttc agttattacc caccagtaag 44460 agaaagttag gttaagggta taaagggatt gaagaggttt ctacttttgc ccagtcctta 44520 ttttgaatag ccttccactc atccaaagtc atctcttttg gaccctcctc ttttacctct 44580 tcaacttcat tctccttatt ttcagtgtct gccactggat gatgttcttc accttcaggt 44640 gtttcctcag tcacatttga ttgatccaag tcactgcaat tataagatat ttgtttctga 44700 atgtatttgg gggactctgt taattcatct ttgacaattc cccagttgtg agatctgcta 44760 cctccacgtt acaggtcctc gtgcttcagg ccactgtaat gtgaaaaaaa agatctatca 44820 cttccactat acctatcaaa ttcacgtttg ccacgagaat caaatccatc tccttggccc 44880 atttcacgtc cactgccctc tcgacctctt ccaagaccac catgaccttg aataggtcgg 44940 tcaataatca gtctatcaac tgaaaattcg cctccttcac ccctttcatc aagtggcttt 45000 tcaagtcttc gttcacaagg tggtctcctt tctggtcttc tatcagttat tttcccttca 45060 ccgtgaagtt gttgagcagg tcttcttcca acttgtctta ttccttcttc tttttgtgtt 45120 ttttattttt cctctaggca agctttattc tttgattcct ctatccagga agggggctgt 45180 tggttgcatc ttacccaaat ggaatgcaat gggaattggg agcttgagtt gtgtggagga 45240 ggagttgtca atcttaacaa atgactatag ctggcgtgtg gtgtccatca atccttgagg 45300 gcttggccat gcacactagg gaatggtcag aacagactca acagaggtct ccagagcttt 45360 acaatatcta caatatcaag gttcaggggg tatagacagt aaggaaaaag gccatttcct 45420 gtttctgtcc atttttggta cagtagacag ttaaggtttt ttcttttgac tagcttttaa 45480 aaaattactt agaaaatgga aagcttataa acattcataa gtgaattgtt gaattgctac 45540 cccaagtggt ttccttacct agtcaccact taaccagaaa tactagaata cacggttcaa 45600 ccagaattca accaggcaga taacctgcct attgctcaag caatcatcag agtttttaaa 45660 aacaaaatta agcaaaaaag acctttcccc aaatacaatc attactttgt atgacccatt 45720 cctaagaaag ctacattcca tttcagaaaa catgaccact taaggtacag ttaaaacaaa 45780 gtcgttgcct tcaggtgctt actttctgtt ttctttaaat taactgctga aatgtttatc 45840 ttgtgttttg tgctgcattc ctgaaaactg taacttttaa ggacataggc ctcatcttta 45900 taaaggaaga agaaaacagc aaagaggtgt ctcatttggg aggcagaagg ttatgaccaa 45960 tgctggaagt cttcctcttc cttacttgtt gttcaacaag atgggttctg tggtgtcgca 46020 tgaggtgtga gttggaaatg aaagctgcac cacacttctt atattcatag ggcttctccc 46080 cagtgtgggt tctctggtgc accgtgaggc tcaacctctg tctgaaggcc ttcccacact 46140 cattacacat gtaaggtttt tctccattat ggattctctg atgaataagt aggtatgagc 46200 tacatgtgaa ggccttccca cattcattac acacaaaagg aagatctcca ctgtgaattc 46260 tctggtggac aaaaaggcaa gagagctgac tgaaggcttg cccacattca ctgcagtcat 46320 aaggtttctc tgcagtgtga attatctggt acataataag gtgtgaaaaa caactaaagg 46380 ttttcccaaa ctcacactca tatggcttct caccagtatg gcttcgctga tgtacaataa 46440 gatttgcaat ctgcgtaaag gctttgccag aatcgttaca ggcagagggc ttctccccag 46500 tgtggatcct ctggtggaca atatggtttg agctcccagt aaatgttttc cgacactcat 46560 tacatttaca gcatttttct gtaatgtgga gtttctggtg ccgagcaagt tgtgagctat 46620 aactaaaggc tttctcacat ttactacgcc taaaggtttt ttctaaggag aggttttttt 46680 gatatacagt cagatttgaa ctctgattga aggctttccc acattttgag caaacataag 46740 gtttctgtcc agtgtggatt ctctgatgca catcgagctt tgcactctga atgaaggcct 46800 tcccacactc atgacattca aaaggtttct ccccggtgtg gattctctga tgcacaacga 46860 ggtttgcact ctgactaaat cctttcccac acatgctaca atgtaaaaga ctttcgccca 46920 agctgggttt tcggattgtt aacagtgtca gaattaaggc tgtattttcc cacagatttc 46980 ttacatttct ggtcttcctc ttctttgaag ctttcaggta agtgacagtc attcactatg 47040 acttatctga aatctttcct ttccctcctt attctctgcc tctttaacat gttttctttt 47100 tcacaagcct ctcttaactc aggtccttaa ggatcagctt tctggattct tcctaatatg 47160 atgcgggggt tttcagcttc ctcacgtatc tcagtttttg gaaccagtaa ctgaaggttc 47220 ttggtttcag caccttttct tcctcttctg atccatcaag gcctgtctga cgaaactccc 47280 ctggggccca gactttgatg ttctcagagt gcacttgttg gctggatgcc tgatctggga 47340 agttttcttc ttcctcctcc tcctttttca ccttcactgg gcggcatggg cctagggcca 47400 tggcttctct caattctgca gtcatcttct ctgctcagca ggggaacgcc tatagctggg 47460 agctgcccag cacaggtcaa accccatcta agctttatgt ttcaaaagct tcttcttgag 47520 tttcctccca gggccaagat gagtattgcc tacgtgcgca gctgagaggc ccgaccagag 47580 ttcactggct ctgcagcagg aggctggggg accaggacct cagctcctac tggcacgaga 47640 acaatgaccc ttattccttc tttcttaagc accatggacg gctgcgtctc ctctttcctg 47700 tcaaccacgc caacgctgga gggcagcggg ttcttgctgt ctttctggga ctccttgcgc 47760 agctagctat ttgcctgccg ccttggagtt ggtctgggtc gcagcctgag ctgccgctct 47820 tggccccaga gacgccgccc ccgccagctt cttttttctt gttctctcct gccttcagca 47880 cctcgaaggg gtccgattag ttgtcaaata actggtcgaa tcggttggtg accaggcagc 47940 tgaagccttc ctgtaactgc ccaggcatga tggttgctcg gcggcacatt cctccacgga 48000 ttgcagcggg ctgcgccgag ccaagagcgc gtgcttcagc tcttcccaga agatcgaaga 48060 acaatttttt tgaaatccgc ctgtaaatgt caggcaaggt aaatttcaaa atgaattttt 48120 aaagtctcta aaatggagtt atgtttaatt atgactttat gacaaattaa aagatagttc 48180 tagataatac tattgtagaa agaagcttct cttgttctgg gaaagagaga cagtttggaa 48240 acttgagaca agacccttat tgtctgtttt attatttact gctaacaaac tgcattctct 48300 cactgttcac tggaataggt gggtccaggg aacttaggaa agcctaatgg gaagtgagaa 48360 aagtaaatta tttcttatat ttttatgtat acaaatagtt gataaaggag gaagtgtagt 48420 ggtggggtgg atcatgcaga ttgggataca agagacagta taattattca caattataga 48480 taaggagatc taggcttcac attttcactt ctggaatatt ccactttgac agaacagtct 48540 actgtctgcc tcagcctatc ctggagatgt ccttgtggtg ggagaggacc tgctttctcc 48600 ttgctgtgct cctacagttt gtctctgcca gtcatgtcca agccccttgt cttagtgcct 48660 cacaagacct cttcctctga ccaggattca ggcaccttct cagaaccttc attcccctga 48720 cagcaggacc agccagtctc ccagacccgg ggtagtgcga agaggagagc agactcctta 48780 gacccagagt cccaggacac ttggcctcaa ttcccgtgac acctatatca cccagacaac 48840 tgggaaatgg aggtgctggt gccagaacaa aagcataagc tgtgtttctc aagtttggac 48900 tttacctggg ctgttgcttt attttctagc tgtttactga tttttagaag cataaaggtt 48960 tctttctgtg aagttcctag ggacacttaa cggagtgggg acaggtattc cttttgtctt 49020 tcagaaaggc atgttaagag ttagtctcac agtaatttaa gtctcacctc ctaaatgggg 49080 taagagtggg gagaaatata tgtgtgtata tttgtgtgtg tatataaata atatatatat 49140 actactaata taattaataa tgtgtgtata aataatatgt aaataacata ttatattata 49200 tgtcaataat aaaatattat attaatatat gttattacat taatatacta tatattataa 49260 tatataagat ataattatat attatatact attatattat atctataaca taatatatta 49320 tatatttata tatcattata taatgtatta catgtattaa tatatattat ctatatagta 49380 aatatatggg gtgtgtattt gtgtatacac acacacacgc acatatatat cctgcattgt 49440 ttgcttagaa tcatgctttg caattattaa ctgctttttc ttccttccct tcatctaata 49500 cacctgaaga atatttcagt tagccaaagg tgagaatccg aattcatatt tgtattccca 49560 atagatttcc cgcagaatct tgggttatca tttcatcaat aacagttatg cagatgttct 49620 attgctgtgt ccaatgcttg cttcgttcat atgaaatttg acttttggcc attcaaaaag 49680 caatcagtgc cttcttgttg attagcacta atcaccacaa gatccttcca atagtaaatt 49740 ttccagagca aaattctaaa cttacagatt agtttgccgc agcccctagc cctacactgt 49800 aaggatcttg ctttccatga ggtccattgt taaatggaaa tgttcccctg gctctatgca 49860 gtgctcaggt gtttcttact cagctgaagg actaatgaat ttagtttgaa tctaaatttg 49920 gagtaaaaaa tgccactcag gagagctgct tctgtgactg cattgccttc caacctgctt 49980 ttccattttt ccttattact ccatgtcctt gaggagttta ttcctttata gcttttgtga 50040 tctggctgta attattttga aaaaaatttt cattatactg gacattttgg attaagtcct 50100 ccaaattttc ttatttgtga gagtacaagt cactatttac actatggtaa actgcatgca 50160 aacatctgag tacctttctg ttcctgtctt cagctgggcc agcactaagc tggaatagcc 50220 tatactttga tgtttttctg aggaagtaca ttttcctttt ccctcagatt cctggtgcct 50280 ggtatagcac ttttttgatt tgctcttgtt ctggcaatag gtcaactggc tttcatggtc 50340 cttaacgttt caggtaaata attccaacag ttgtgactgg aaggaattca aatcaactca 50400 aggcatccac tctatgttca aaatgccatg ttttgagtga tttgtccttt ggttagtaac 50460 tttaaaaaat atgaggactg gaaggagaag ctactatttg aggaactaat ggaaaatcaa 50520 gcagtttttg atgtactaac atatacactt atgatgcaag gagtgtgatc gttgaccttc 50580 ctacttatct aaacattatg ctctcagagc atgtggatag gtagcatagc ctagtggtta 50640 acacacatag aaaagtcaga ctgcctagtt cgaatcccag cttcatcact tgctagctat 50700 ataatcttta ttaaattagt taactttcct gtgcctcagt ctggttttcc tgaggattaa 50760 atgattttat atttgttaag tgcctagaac tgtagctggt ctgcaacaag tactatacgt 50820 ctttgtttaa ataataaata aaatgacagt attgttcata tggagaaaca ggggtcttag 50880 gcagcttagg agtttttcta aagtaacaga atcatttaat ggcaggaaca acaatattat 50940 cactgcccag aaccctaatg gagaactata gctcttaagg gtgatgtggg gagaaataca 51000 ctgatgaaaa acaatcaaca ttattaaaga caggatggga gagagtggga actcgtcatt 51060 catttatcta atggcttagt cagcaagtaa ctaatgccta ctttgggcct tgacactata 51120 ccaacattgt gcagaaagtg attaaaatgc aaaagaacat tcacttaggc tgggataaac 51180 aagaggtctt ttgcaaaatc tgatgatgag cttgttgatg ttgagttgac aaactatgca 51240 gcaggtcagt gggggggtga ttatcataaa attccatccc ttaaacatct acaggaagat 51300 gattatttta agatgcttta cttctggaga tgtatgcttt acttctactt agagaatctg 51360 gcttatgttc tcatgttctg gttttatatg taattggtca tgagcttaat ttgagccaag 51420 catttgacac agttgccccc agaagttaac tcatttgtgg attgtataaa tgctattgca 51480 caaaaaagaa gtatatatat acaaatagtc atagtagacc acatctcagt taatggcttc 51540 aagtctagat gaaatgtttt aagagggata ttgacaaatt agagaacatt agaagcattt 51600 gccagaatac tggcagggca agaaattatg ccaaatagta gaaagagaat tagatgccta 51660 agtggaacat ggtgtatagc ccataagaat ttgaaggatt gtcactggta gaataagatg 51720 ttattcttgg ctgcttccag ctgaggagtg gtggatgggt gactaaggcc tataagagag 51780 caaatataag gaagagtttc tagatattaa aatcaatttc caaagaaaca gcctggcctc 51840 taagggaaag agcttcttgt gagtagatgt gtttaggtgg ggccagatga acaagctcct 51900 gagctctagg gattagactc cttctgctgg ataggaggta caaccaggtc atcccagagg 51960 ttccttgtgt tccaagattc tgttactcta tgatttcatg acttggatgt cacctccctt 52020 aggttggtta ctctaaataa tgttaaaagt cagtgtatgc cttaagattg ggtgaattgc 52080 tatgacagaa tgagatttac cagagaagca gttaagtcta agaatgaaac tactgtttct 52140 aagtgaaaga ggtatgaata acctaaagat aatatttttc tctgtagata gaaagaattt 52200 gtattataag tctgtgttgg gtgtatagta gggcatcacc agaattcacc ctaactgggt 52260 gaattcatgg cagtgatcag tagaatatgt agtttaacaa tgaggcctta tcatttctaa 52320 gtagtttctt tttgagacgg agtctcaccc tgtcaaccag agctttgccc tggaactctt 52380 ggagtgcaac ggcgcgatct cgggtccctg caacctccgc ctcccaggtt caaacaattc 52440 tcttgactca gcctcccgat ttctaagtgg agagttatga atggcccaaa gataatattt 52500 ttctctatag atagaaataa tttgtatgct aggtatgtgt tggatatata gcaggacatt 52560 accagaattc agcctaactc ggtgaattca tggcagtgaa cactgcaata tgtggtttaa 52620 taatgaggcc ttattcttaa ggcaaagctc agaaaagctg ataagcaaat tagaaaggtc 52680 tattgaaaag tgtctgttgg ccgggcgcag tggatcacgc ctgtaatccc agcactttgg 52740 gaggctgagg cgggtggatc atgaggtcaa gagattgaga ccatcctggc caacatggtg 52800 aaaccccgtc tctactacaa atacaaaaat tagctgggca tggtggcatg cgcctgtagt 52860 cccagctact cgggaggctg aggcaggaga atcgcttgaa ccatggatgc agaggttgca 52920 atgagctgag attgtgccac tgcactccag cctggtgaca gcaagacttt gtctcaaaaa 52980 aaaaaaaaaa aagaaaagtg tctgtctagc caggcgtggt ggttcatgcc tgtaatccta 53040 gcactttggg aggccaaggt gagtggatca cttgaggtca ggagttcaaa accagcttgg 53100 ccaacatggc gaaaccttat ctctactaaa aacacaaaaa attaacagga tgtggtggtg 53160 cacacctata atcccagcta cttgggaggc tgaggtagaa gaatcgcttg aaccgaggag 53220 gcagaggtag tagtgagcca agattgtgcc acagcactcc aacctgagca acagaacaag 53280 actcagtctc tgaaagagag agagagatga aagagagaga gagagaaaga aaaagaaaga 53340 aagagagaga aagacagaca gaaagaaaga aagaaagaaa gaaagaaaaa gagaaagaga 53400 aagaaagaaa gaaagaaaga aagaaagaaa gaaagaaaga aaagaaataa agaaagaaag 53460 caaagtgtct gtctgccaac ctgcttccac aaaggcccct cttctgattg tagaagtgcc 53520 tggtttagga tggcagtgtg ctctacctgc tgtctggtga gtagtcagga ttggacttct 53580 ataagacacc ctctgagagg cttgcaaata ccttcagaat caggcagagg tctttggcca 53640 gttatttctg aataaagcat atctgcgtgt ctgtctgacc taagcctggg aaccacgatg 53700 gaagatactg tttgaacaac aacaacaaca aaaaaaggca gggaacttaa gagagaaatg 53760 gattttagtc actaagaaca cgaagaggaa cattttgata atatgtactc tatacaaaca 53820 gaatgcttat acaagacaat caaagaggaa tgggtagttt tctaaagagt aaaacctgta 53880 tttttaggaa catatatttg tttacaatat attttttctt ttttcaccct tgatttttaa 53940 ctatttaata attttctaca acattttttt cttttttttt ttttgccctt tttttttttt 54000 ttttaaacag agtctcgctc tgttgcccag gctggagtgc aatggtgcta tcttggctca 54060 ttgcaacttc cgcctcctgg gtttaagtga ttctcctgcc tcagcctccc gagtagcttg 54120 gattataggc acctgccacc acacctggct aatttttgta tttgtagtag tgacggggtt 54180 tcaccacgtt ggccaggctt gtctggaact cctgacctca aggcccacct tagcctccca 54240 aagtgctggg attacaggtg tgagccaccg cgcccagcct gcccttgatt tttaactatc 54300 cctcctgtga aaatttaagt ctttctgtgg gttaaaggga actggtaaag agcactggat 54360 ttatgcttgg gctggaattt ccctctaggt ttggatgtaa tgaaggcagt agagatttgg 54420 gtttataaca gaggcagatt tgtgaaacta taggagttga agcctgaggg tccctcactt 54480 gcagagaccc cttccagggt cctggaagga accctgctaa tgtgttatta tggtcatttt 54540 ttttataaaa attgcaaaac ataatgtgtt tcagccatga ctggttaaga tcattgtctt 54600 cttccaattc aactttccct cctttctcct tccctttcta gttgggtggc attaaagtgg 54660 tcatgcgcat tttgtatttg taattatgta tttttttttt ttcttaaaaa ggaccccccc 54720 accaaattgt ataagtttca ggccctaaaa acatggatct tccactgggt gtaggaatgg 54780 aatgagtaac aatttggaaa ttgcctgtgt agcagaatca gcgaaaagtc agagtcagca 54840 gtcaaaatgt gatggggaga gtgagagtaa attggaatcc ataatcccaa cagcatttga 54900 cagtgggaaa atggagcttt ttcccccctc tttagggttc attttaaaga attccatgca 54960 aaggatatca tgaattgaga aatatacatc agattcatca gattaaaaat tttttttttt 55020 tttttgagac ggagtctcgc tctgtcacca ggctggagtg cagtggcggg atctcggctc 55080 actgcaagct ccgcctccca ggctcacgcc attctcctgc ctcagcctcc cgagtagctg 55140 gaactacagg cgccaaccac catgcccggc taattttttg tatttttaat agagacgcgg 55200 tttcaccgtg ttagccagga tggtctgatc tcctgacctc gtgatttgcc cgcctcagcc 55260 tcccaaagtg ctgggattac aggcgtgagc caccgcgccc ggctttttgt tgtgtttttt 55320 gtttttgttt ttgttttttt gagatggagc cctgctctgt cgcccaggct ggagtgcagt 55380 ggcacaatct cggctcactg caacctccgc tcccaggttc aagtgattcc cctgcctcag 55440 cctcccgagt agctgggatt acaggcacgc gccaccatgc ccggctaaat tttttgtttt 55500 ttagtagaga cagggtttca ccattttggc caggatgatc tccatctcct gacctcgtga 55560 tgtgcctgcc ttggccttcc aaagtgctgg gattacaggc gtgagccact gcacctggcc 55620 taaattcttt ttaaaaatag caaattctta aaaataatgc aaattgatga tgaattatga 55680 aaatcatgat gagaaactcc tgactgaaga gagaaattgt tggaaaatga ttctcctttt 55740 cctctactac tttatgtaat tataaagcct ttttctaaag ttcctttctg acacagaaat 55800 actggccaac agaaattcaa aggaaagttg agacttttga agttcaggca atttatatgg 55860 tgtttcaggt gttactacct ctaatagtct atcagtaaaa ccctgatagg ggatggtctc 55920 tcctttttgc cttctactcc atctcttctc acacacactt gtgattcttt ttcttttttt 55980 aaaaaatttt attattataa tactttaagt tttagtgtac atgtgcacaa cgtgcaggtt 56040 tgttacatat gtatacatgt gccatgttgg tgtgctgcac ccattaactc gtcatttagc 56100 gttaggtgta tctcctaatg ctatccctcc cccctccccc caccccacaa cagtccccag 56160 tgtgtgatgt tccccttcct gtgtccatgt gttctcattg ttcaattccc acctatgagt 56220 gagaacatgc ggtgtttggt tttttttcct tgcgatactt tgctgagaat gatggtttcc 56280 agtttcatcc atgtccctac aaaggacatg aactcatcat ttttatggct gcatagtatt 56340 ccatggtgta tatgtgccac atttgcttaa tccagtctat cattgttgga catttgggtt 56400 ggttccaagt ctttgctatt gcgaatagtg ccacaataaa catacgtgtg catgtgtctt 56460 tatagcagca tgatttataa tcctttgggt atatacccca gtaatgggat ggcaggttca 56520 aatggtattt ttagttctag atccctgagg aatcgccaca ctgacttcca cagtggttga 56580 actagtttac agtcccacca acagtgtaaa agtgttccta tttctccaca tcctctccag 56640 cacctgttgt ttcctgactt tttaatgatc gccattccaa ctggtgtgag atggtatctc 56700 atagtggttt tgatttgcat ttctctgatg gccagtgatg atgagcattt tttcatgtgt 56760 tttttggctg cataaatgtc ttcttttgag aagtgtctgt tcatatccct cacccacttt 56820 ttgatggggt tgtttgtttt tttcttgtaa atttgtttga gttcattgta gattctgcat 56880 attagccctt tgtcagatga gtacattgca aaaattttct cccattctgt aggttgcctg 56940 ttcactctga tggtagtttc ttttgctgtg cagaagctct tgagtttaat tagatcccat 57000 ttgtcaattt ttgcttttgt tgccattgct tttggtgttt tagacatgaa gtccttgccc 57060 atgcctatgt cctgaatggt attgcctcgg ttttcttcta gggttttcat ggttttaggt 57120 ctaacatgta agtctttaat ccatcttgaa ttaatttttg tataaggtgt aaggaaggga 57180 tccagtttca gctttccaca tatggctagc cagtattccc agcaccattt attaaatagg 57240 gaatcctttc cccatttctt gtttttgtca ggtttgtcaa agatcagata gttgtagata 57300 tgcggcatta tttctgaggg ctccgttcgg ttccattggt ctatatatct gttttggtac 57360 cagtaccatg ctgttttggt tactgtagcc tagtagtata gtttgaagtc aggtagcatg 57420 atgcctccag ctttgttctt ttggcttagg attgacttag cgatgcaggc tcttttttgg 57480 ttccatatga actttaaagt agttttttcc aattctgtga agaaagtcat tggtagcttg 57540 atggggatgg cattgaatct ataaattacc ttgggcagta tggccatttt cacaatattg 57600 attcttccta cccatgagca tggaatgttc ttccatttgt ttgtatcctc ttttatttcc 57660 ttgagcagtg gtttgtagtt ctccttgaag atgtccttca catcccttgt aagttggatt 57720 tctaggtatt ttattctctt tgaagcaatt gtgaatggga gttcactcat gatttggctc 57780 tctgtttgtc tgttgttggt gtataagaat gcttgtgatt tttgcatatt gattttgtat 57840 cctgagactt tgctgaagtt gcttatcagc ttgaggagat tttgggctga gatgatgggg 57900 ttttctagat atataatcat gtcctctgca aacagggaca gtttgacttc ctcttttcct 57960 aattgaatac cctttatttc cttctcctgc ctcattgccc tggccagaac ttccaacact 58020 atgttgaata ggagtggtga gaaagggcat ccctgttttg tgcccgtttt caaagggaat 58080 gtttccagtt tttgcccatt cagtatgata ttggctgtga gtttgtcata gatagctctt 58140 attattttga gatatgtccc atcattacct aatttactga gagtttttag catgaagcat 58200 tgttgaattt ttacaaaggc cttttctgcg tctattgaga taatcatgtg gtttttgtct 58260 ttggttctgt ttatatgctg gattacattt attgatttgc atatgttgaa ccagccttgc 58320 atcccaggga tgaagccagc ttgatcatgg tggataagct ttttgatgtg ctgctggatt 58380 cggtttgcca gtattttatt gagaattttt gcatcaatgt tcatcaagga tattggtcta 58440 aaattctctt ttttggttgt gtctctgcca ggctttggta tcaggatgat gctagcctca 58500 taaaatgagt tagggaggat tccctctttt tctattgatt ggaatagttt cagaaggaat 58560 ggtaccagct tctccttgta cctctggtag aattcggctg tgaatccatc tggtcctgga 58620 ctttttttgg ttcgtaagct attcattatt gcctcaattt cagagcctgt tattggtcta 58680 ttcagagatt caacttcttc ctggtttagt cttgggagga tgtatgtgtc gaggaattta 58740 tccatttctt ctagattttc tagtttattt gcgtaaaggt gtttatagta ttctctgatg 58800 gtagtttgta tttctgtggg attggtggtg atatcccctt tatcattttt tattgcgtct 58860 atttgattat tctctctttt cttctttatt agtcttgcta gcattctatc aattttgttg 58920 atcttttcaa aaaaccagct cctggattca ttaatttttt tgaatggttt tttgtgtctc 58980 tatttccttc agttctgctt tgatcttagt tatttcttgc cttctgctag cttttgaata 59040 tgtttgctct tgcttttcta gttcttttaa ttgtgatgtt agggtgtcaa ttttggatct 59100 ttcctgcttt ctctggtggg catttagtgc tataaatttc cctctgcaca ctgctttgaa 59160 tgtgtcccag agattctggt atgttgtgtc tttgttcttg ttgctttcaa agaacatctt 59220 tatttctgcc ttcattttgt tatgtaccca gtagtcattc aggagcaggt tgttcagttt 59280 ccatgtagta gagcggtttt gagtgagttt cttaatcctg agttctactt tgattgcact 59340 gtggtctgag agacagtttg ttataatttc tgttctctta catttgctga ggagtgcttt 59400 acttccaagt atgtggtcaa ttttggaata ggtgtggtat ggtgctgaaa agaatgtata 59460 ttctgttgat ttggggtgga gagttctgta gatgtctatt aggtccactt ggtgtagaac 59520 tgagttcaat tcctgggtat ccttgttaac tttctgtctc gttgatctgt ctaatgttga 59580 cattggggtg ttaaagtctc ccattattat tgtgtgggag tctaagtctc ttagtacgtc 59640 actaaggact tgctttatga atctgggtgc tcctgtatta ggtgcatata tatttaggat 59700 agttagctct tcttgttgaa ttgatccctt taccattatg taatggcatt ctttgtctca 59760 tttgatcttt gttggtttaa agtctgtttt atcagagact aggattgcaa cccctgcctt 59820 tttctgtttt ccatttgctt ggtagatctt catgcgtccc tttattttga gcctatgtgt 59880 gtctctgcat gtgagatggg tttccttaat acagcacgct gatgggtctt gactctttat 59940 ccaatttgcc agcctgtgtc ttttaattgg agcatttagc ccatttacat tcaaagttaa 60000 tatcattatg tgtgaatttg atcctgtcat tatgatgtca gctggttatt ttgctcatta 60060 gttgatgcag tttcttccta gccttgatgg tctttacaat ttggcatgtt tttgcagtgg 60120 ctggtaccgg ttgttccttt ccatgtttag tgcttccttc aggagctctt ttagggcagg 60180 cctggtggtg acaaaatctc tcagcatttg cttgtctgta aagtatttta tttctccttc 60240 acttatgaag cttagtttgg ctggatatga aattctgggt tgaaaattct tttctttaag 60300 aatgttgaat attggccccc actctcttct ggcttgtaga gtttctgccg agagattagc 60360 ttttagtctg atgggcttcc ctttctgggt aacctgacct ttctctctgg ctgccctgaa 60420 cattttttcc tgcatttcaa ctttggtgaa tctgccaatt atgtgtcttg gagttgctct 60480 tctcgaggag tatctttatg gcgttttctg tatttcctga atttgaatgt tggcctgcct 60540 tgctagattg gggaagttca cctggataat atcctgcaga gtgttttcca acttggttcc 60600 attctccccg tcactttcag gtacaccaat cagacgtaga tttggtcttt tcacatagtc 60660 ccatatttct tggaggcttt gttcatttct ttttattctt ttttctctaa acttctcttc 60720 tcgcttcatt tcattcatct tccatcactg ataccctttc ttccagttga tctcatcggc 60780 tactgaggct tctgcatttg tcacgtaatt ctcgtgcctt ggttttcagc tccatcaggt 60840 cctttaagga cttctctgca ttggttattc tagttataca ttcatctaat tttttttcaa 60900 agtttttaac ttctttgcca ttggctcaaa cttcctcctg tagctcggat tagtttgatc 60960 gtctgaagcc ttcttctctc aagtcatcaa agtcattctc catccatctt tgttccattg 61020 ctggtgagga gctgctttcc tttggaggag gagaggcact ctgattttta gagtttccag 61080 tttttctgct gttttttccc catcttggtg gttttatcta cctttggtct ttgatgatgg 61140 tgacgtacag atgggttttt ggtgtggatg tccttcctgt tcattagttt tccttctaac 61200 agacaggacc ctcagctgca ggtccattgg agtttgctag acgtccactc cagaccctgt 61260 ttgcctgggt atcagcagcg gtggctgaag aacagcggat attggtgaac cgcaaatgct 61320 gctgcctgat cgttcctctg gaagttttgt ctcagaggag tacccagccg tgtgaggtgt 61380 cagtccaccc ctgctggggg gtgcctccca gttaggctac tcaggggtca gggacccact 61440 tgaggaggca gtctgcctgt tctcagatct caagctgcgt gctgggagaa ccactacttt 61500 cttcaaagct gtcagacagg tacatttaag tctgcagagg ttactgctgt ctttttgttt 61560 gtctgtgccc tgccctcaga gagggagcct acagaggcag gcaggcctcc ttgagctgtg 61620 gttggctcca cccagttcga gcttcctggc cgctttattt acctaatcaa gtctcagcaa 61680 tggtgggcgc ccctccccca gcctcgctgc cgccttgcag ttcaatctta gactgctgtg 61740 ctagcaatga gcgagactcc atgggcatag gaccctccga gccaggtgcg ggatataatc 61800 tcctggtgtg ccatttttta agcccattgg gaaagtgcag tattagggtg ggagtgacct 61860 gattttccag gtgccgtctg tcaccccttt ctttgactag gaaagggaat tccctgacct 61920 cttgcgcttc ccaggtgagg cgatgcctcg ccctgctttg gctcgcactc ggtgtgctgc 61980 acccactgtc ctgcacccac tgtctggcac accccagtga gatgaacccg gtacctcaat 62040 tggtaatgca gaaatcaccc gtcttctgtg tcacttatgc taggagctgt agactggagc 62100 tattcctatt tggccatctt ggctcctccc ccagatcaca cacttgtgat tcttgctggc 62160 attcacactt actctctctt tattttttga gacagggtct cactttgtca tccaggctgg 62220 agtgcagtgg tgccatctca gctcactgca gcctccacct ctggagctca agggattcga 62280 gtagctagga ctacaggcgt gtacctccac ccctggctaa tttttgtatt ttttgtagag 62340 ctggggtttt gccatgttgc ccaggctgat ctccaacacc tgggatcaag cagtctgccc 62400 accttggcct cccaaagtgc tgaaattaca ggtatgagcc tccatggctg ggcacttact 62460 gtctttttaa ttatcagctt gcaaatgaga aatctgccca aggagcctga gcttggtgaa 62520 tacaagttca tttcagcccc attggtgagt ttatgattct atgagacttt aaagatgtat 62580 tttatttgga catgttaaaa aaaaaaaaaa agaaccgtgt gtttcttcac aacatccaaa 62640 ataattattt tattggtatt gataattatt attgaggaat agggaagtca tgtatgttat 62700 caaccacttc ctaaatgata cctagttaac acgttagggg agggaatcga atctgaaagt 62760 gatacccatt tagtgaagcc aagcaatgta gcaagagttg agaaaaactt ataaagggac 62820 ctcttagccc atgtccataa cattgtcgtt aacataaaga taggttgcca gagaaagggt 62880 aactgtatgg tcaatttagc caggtctgaa ctctcaaaaa tcaagcactc tcattctgtt 62940 agggtgaagt cagagaaaag aaccttcaca aggtttgaaa acacagttgt aacatactgg 63000 gctgtgttcc agggctagca tttgactctg atttttatct tgtgcttaga accagcctac 63060 tgttgtctct gtgcagagag agtactaagt aggtactgaa taatacttgc tgtccagcac 63120 atagctctgt gcagaacgag cactaagtag gtacttaata atgcttgctg gccagcacat 63180 ggatggatca tgtttataag tgtgtatcat aaacactttg ccttgaggaa attgttttct 63240 ttttagagtt ttcatactgt ggacatcctt aaaaagccca gaaaatgtat ctttatggat 63300 tgacatgtga cttcttacat atgaagttag aagccaatga aatgctgttc tttggactga 63360 actttcaaga ctcatgtgtg tggtgtctaa ttcattaact aaaaatatga ttcatattta 63420 ccttatgtag gactacaggt atccacatat ccaccattag gatattcttt aaatctggta 63480 gtttggaaga tttccagaca ttgtaaagag taaatgcatc agaaataagc attttccaga 63540 agagggaggt atgaaattgt aatgattagc ctgttgctta gtcctggaaa tgtgaaatca 63600 gataaaaatg aaaaagatgc tttccttgca ttctcttcca gaaatatgca gcctgctgct 63660 cttttgtctt cagtgtgacc atgctgccct gaggagagcc cagaactgtt tttaaattca 63720 aaaggacagc tgctttctgc tcactcaggt ccactgaggc atgctccaag acaggaaaaa 63780 ggtgcttagc ggggctcttt gatagagatt caatatatga attttacttt gagaataaaa 63840 agctcaccca cttttaaaag gttaatcaaa agctcattgt agtgtattct tcctttccta 63900 tgcagtttcc tatggaaatg gaatcagttt aaattctggc ctcagaacag caatattttt 63960 cacagaggca gtccttctgc caagtggctc tagaagtacc cgtaatatcc atgtcaggag 64020 tatgaaaaat gaaagggatg aacacttcct tcagaaatta tacctttgat tcctttactt 64080 tacggccagg caggaagaat cctgagagag gtctttactg aaagttcagt atttatgaac 64140 tacatactga aaaatgaaaa acgattccta gcactgagtt gcttaccctg tcaagtttac 64200 ccattatttt caggctgttg agcattgttt gaaaaatcga tctgagagct aaatgagact 64260 ctgtccctta ccatggtctt gctgttataa attcacactg ggctatttcc attccctaag 64320 tttgctttgc cctttcctac cctttacctc tatggtcttc catccggtaa attttctctc 64380 acccttcctg gtctagctct atttcatctt cacttatgaa ggcttccttg ttttcctttt 64440 ttagaattaa ttgctaattc ctcactgctc tctaagcatt aataccccca tcatagcctt 64500 catcataata tgttttgtgc tgtagttatt tatgtactta cttgtttttc ccccttcttt 64560 gctctttgat taaatgcatg ccagatccaa ctttacagat gagaaaaatg agctctgaag 64620 ttcaataact tgcccaaggc tacccagtta gaagagttat ggacttcact ctgaatatgg 64680 tgacttttgt tctagtgtgt tgccttctct agtcttctta agaaaaacct tgtcttcttt 64740 tcttttttcc ttaggttgac ttattctata cattagaagt ttctaaattt taatcaaact 64800 gtcattccag ggtcatagtc agccacatgt aaatcagaat gcagttttac atagattcat 64860 tattactgtg catggagatt agaagccagc tcacaagaag acttaatttg gaaagatatg 64920 taaccaactt cacgtaagtg ctagcctttc attgatttct cacctccatt ctatattcct 64980 cctggcactt gttttaaatc tgttctactg aagtccatac tctaccccct tgctctcagc 65040 cgatgatctg tttacctgct ctgagaagat ttagatcagt agttctcaaa ctttaatatg 65100 tataaaaatc acatgcagag ctctttctaa catagtttcc cgggactttt cccaggaatt 65160 ctgatttcag caggtcaggg tggggctcat gaatgctcca ttctaacaag ctcccaggtg 65220 atggcaacac agctggtctg aggactacac tttgagaacc tctgatttag gccatcctct 65280 gcaataggat gtcttctcca atacatcttc tctggatatt tatccttcct ctccttctat 65340 gagaattcag tcgttctatt ctcaggctga accctctcac cacgagcttt tatcccatct 65400 catttcatct atttcaggac cttgcttcaa cttggctctc tttgaatctt ttatatcacc 65460 ctctcaattg ctttttattc tctactgctt tactaataaa actgttcctt tctcagttgt 65520 actatttaag atacatctaa tgattgtaag caaaattatt ttctctaaga atggtcgaca 65580 atttcagatt caactcagct ggctaggaac taagtttctg taatttggga attggcttgt 65640 agagagcaaa attaagaaac caagtttggc cgggcacggt ggcttacgcc tgtaatccca 65700 gcactttggg agtccgaggc aggtggatca cgatgtcagg agatcgagac catcctggct 65760 aacacggtga aaccccgtct ctactaaaaa tacaaaaaat taaccgggcg tcgtggcggg 65820 cacctgtagt cccagctact cgggaggctg aggcaggaga atggtgtgaa cccaggaggc 65880 ggagcttgca gtgagcggag atcgcgccac tgcactccag cctgggcgac agagcgagac 65940 tccgtctcaa aaaaaaaaaa aaaaagaaac caaatttaac tttttttaat ggatgtgagt 66000 ggaagagact aatgagataa cacaaaagag ttaacttctt acatttctgt agtctaatac 66060 gagatagttt ctccaggaat taacacagca catctggttc actgacctga gtttgtttcc 66120 tggtgaggca ttgcagtatc atccatatct caggcaaagg tactccagca ttttgtagtt 66180 aagcagttgg aggaggagta gggagaactg ctgtactttg aaacatttca cagtggacta 66240 ctttgcattc taatgatgtt ctccttactt aaggactttg ttatgtaagg atactttgtc 66300 cttctgataa tcacttacac ttttcttctg tgttcatgtc acttcattaa tcctgattac 66360 ttgtaatgaa tcataatctt acccacttat tcttgtgtga ctcattccta cttgtattct 66420 taatagtatt ttctatgtct gataacacat tgtcaattga ctatgctatt tttaacgtaa 66480 gcgttggcaa aaaggtttac ttagagaaaa gctctacatt taattccccg gtgcctcagt 66540 tcccaaattt gctaataaag attatactta gctgtcactc cacgtttcat cagtaggatt 66600 aaaatgaata gagatcatga aataagacaa tgaaaaaaga taattataat ggaccagatt 66660 gagaaatccc tacaaatcaa cagaagcgac ctgccatgtc agattcctag atgcagttta 66720 tttactcagt gggccatatt tcttccttat tctttctttt tccatgatgc cttccaaaac 66780 tatattttaa ccaggaggga aataccattt gtcttctgat ataggaagat cctactgaga 66840 gattatattc atatatttcg tccatcggcc tgtaggtgga attgtattta aaatactaat 66900 aaaggttatt attgcttata tatctaaaaa tgctccaact gtccaaacaa agcttatact 66960 gttgatgata tttatcagtg gctctgaaca cttgcatatc ataaaattct ccctcaaaat 67020 ttaaccttaa actctttcag gcttgtcttg gtcacagtgg gaactgagga cagctgctca 67080 tgttttttga tagaacagct cttaacatgc ttttgctctt gcctcccact gcccaacacc 67140 agctgcatac acacagtcta cttgctgtgt gcatgctctg gctcctgtct ccttttcctt 67200 cagcctagtt agcctggttt tgtttggttt catcatacaa tgtatctatt agtaaaactt 67260 ttatgaactc tgattatagt actaaactca taataaagta atcagaactt catttattaa 67320 aacactgtct tgagcttatt ttttaattta gtacacatga caatttggta aggtaggaat 67380 tttcattccc cttttataga tgggaaaact gaggtccagg atataggtaa cattttcaaa 67440 gttaactcgt aagtaaatgg cttagctgga atttgaaccc aggtttctgc aattctaaag 67500 cccatccttt taactgctat gctatgcgca caattactgt attcttattt gctctctgaa 67560 atacaacacc ttattctcat ttcatctgct ctttctgccc tgtacacttc agtttctgct 67620 ctatagatac ctgctcgtat tgtgacatct caattttttt tgtaccttgg cagggttttg 67680 attgatgtat tggtgttctg aactctttag catatgtatt aatagggaag acctaccaaa 67740 tatttcatgt aatagggatt attttgtcta cctattttat ctttctttat aatgtaagtt 67800 tgtagagggc agaaactata aattgctcag ttagggactc cacattgagc caagcacata 67860 catacttgac ccagagaagt catcaccatc tttatcgcca cagctaacat atgggtagtg 67920 ctcaccatct accaaacatg tgcatggatt attttattta ctcttcacaa taaccctata 67980 aagtagacta tgttgccatc cccaaggtta aaaaactagc ccaagttcat cgagttactg 68040 catgatagag tttgagtcta accaacacca atctacacgt ctgtcaacac agttaactat 68100 cccacacttc tcagtggaat ctagagttcc acttatttcc tattccttcc attcttcact 68160 atatgtcctc tttgccttct tatcctgttt ctctacttct cactttctgc cctatacgta 68220 tctgctcaat cttcaatctt ctctgcctta ccctctcttt ttcaattttg ttctcgttct 68280 gtcctatcct gcctccccac tcttcttacc tcattttcct agtcctcttt tcttcttttt 68340 ttcacctttt tacctcttac atatttcttt tttaaaagta acttcaagct tgataataga 68400 ttcttcaacg ctcttagcaa tatcgtatcc taaccataat aaaatgatag tgtgctaggt 68460 gtaaacagaa gtagaatatg aaattgaaat gaagaatctc tttacttttt ctattagaaa 68520 cataaataat gagtgactgt aacatcttgg tctccataat ttctaagtgt taaataaaac 68580 acatttcttt ttttatttaa cacacacaca tccacacaca cataaacttg ttttatgcat 68640 tgattgccat ttattgagca gcatattttt ggaaatgcaa caactacaaa agaattttta 68700 agttattatc atacagtgac attaataggc tcatcacttt gccttctttc cttgttctat 68760 catgtagagg gttgctttag agatcattgt gtattgatat gaattatcat tgaagtttta 68820 ttagtctgga tgtctcatct tgggcatttt gataaatttc ttttgctcca aatccagaag 68880 ttatggccat tcatctttat aaataagact ttttaaaaaa ggtaaagtca taaaataaat 68940 atttcaaagc agtgttggat atagccagct gaataaactg ccctttctag ttaactttga 69000 actctaaacc ttatttaaat atcctccctt tttttctgta aagaagacga gaaaaaaaaa 69060 caatttcagt agattctaaa agaaaatata gcaagaacat tttcataaga gatatctcac 69120 ataaaaagct gtaaaaattg ggcaagtatt tgcacctaac cagtagaact tagaagagaa 69180 aacatgaaat gaacttctta gcttatggaa tggtgtggat aggtttgcat tacttagatg 69240 ttcacagagc tctagcattt acttactgaa acactggaat ggttcatatc cctgtggttt 69300 ccaccttatt tcttccagaa ggattaggtt ttatgctgcc agagaccaca ttgactctta 69360 gtaatgggat cactaaattc tggttcacaa ttttgtgcat agagagattg cactaatatc 69420 tcaaaattgt agctatgatt ataaccctgg catagaaatc tgagctatgc tggcagtgtc 69480 atgctgtaca atcgaatcca cctgattatc tctgcatttg tgacagctgg gctggccttc 69540 attggcatat gcctctttgc tgtgcccagg gctttgaatg caaaatgaaa gatcagcatg 69600 atattagggg cccatgatcc atagatggag cttcacaagt gaacagcgtc tcagctttaa 69660 catggccccc agtatcctgc tttatctttc tggactgaag ttcctatgac agatttgttg 69720 ctttaaaaaa gtaattttgc agatttgtcc ttttttaaaa gaaataaaga ttgccttcca 69780 tttcctactg aaagtgatat ggtagtatcc atcttataat tgcacagatt caaaaataag 69840 ccacaagtat gtgtgctgaa gtataactgt ggactataaa atacagatat catagcctat 69900 aatatggagg gtagtgtgat gttataaagc catttttctg tgttttacat tatcataaaa 69960 tttaactact gaagggaaag tgaaggtttt aatatttaac taagcctagc acttgaagag 70020 aaacacatat attttacttg gaaaaaaagg aagttccatt ttggacactg caaatgacag 70080 tgccagctgt tgtcataata tttctaacat ccgctgagga ttaattccag gcccagcaaa 70140 ttcactggat gagcagaaac agccaaagaa gtaaacactg gagcttatgc tgtgatatta 70200 ttaaattagg catgagactt ctacagagtt ggatatgtag tgaacactgg attatcatgc 70260 ctgaggatcg tttgctttgt gtatatctgc agaaaattga atcctgaact tgctttcttc 70320 tgcctcttgg ccctcttcct ctgtagaggt atactcagaa aatgtgatct catttgaata 70380 taaacttttc tattaatatt cattaagtac tcatacaata taagctgagg aaacaaagtg 70440 gtgggtgtaa aacacaggcc tcatgtaaag agcttacttt cactacagag gcaatgtagc 70500 ataatgaagc agagatgggt ttcagaggca ggtagaccag aattcaaatc ctacttctcc 70560 taagtatggc cttgggccca tcacttaaat ttctgagact cagtttcctt ttctatgaaa 70620 ggtagatact aatcatgcta cagagttcta ttaagaatta gaaatattta aagatactta 70680 gaccactaca aggtagctat ttttctagaa caggcatacc ttattgtata cattctatgt 70740 ttctagaaca ggcatacctt attgtataca ttctatgaaa cagaatatgg aaagtgctaa 70800 atgaaaggca caatcagaga attccccagg ccctcaagaa ggaaggcgga atggatgagg 70860 aagtctgctg tccaaggggt gggccagagc taaggcaaga tttgtgggtg ggccttcact 70920 aaccaggcac agggagaggg cattccagga gcagatgtag atctggccaa ggaattaaga 70980 caggaatgca agtggcgttt tccaggcaaa agattaggaa gttttagatc agcctggata 71040 tggagacctt gaatagcaag ccgactgagg aatgcatgaa agaatgacta ctagctggaa 71100 taagagataa atctcaaggc ctcttttctc tttcacctct cctcttgccc acatcatgga 71160 cagatagttc tggcttttcc ttatactctg tttctgtaag caattttaag aaggcagagt 71220 gcataatggt attactttta tgtctgcgtg tgtattgcca ccatgaagcc tatagttttg 71280 cttttcaaac tactagattg tgaccttgta atgatctggc aaaaggctga atttttaaaa 71340 gcagtaaatc catatagtgg ataatattgg gaaaaaatta gggctaatac tgaggaatga 71400 gaagattagg aaagagataa ataaaatatg ggtggtataa ataaaaatta aagtgaaaat 71460 gtggggaaag gactgcttat gattcacctt acaaaatttc taccttatgg ggtctgtttt 71520 cactgtcagt tctttctgtg aatgcatgtt catgaagata ctgaaggctg tttttctata 71580 ggcagctggt ggttttctgc tgtaggcaga agtggttgag gtaatcctag ggaggtgatg 71640 ctgaatgggg ctgtggttct actttatgta aggttattat atgtgaaaga aagagtaatt 71700 tttaaaagta attaactagt ggtagattct gaactaacat tagcaaaggt tgattataaa 71760 tcagatttta tttttactac tgatttagaa aaaatctttg gagaaataga tttggaatgg 71820 ttaaatatca ctttagggag cacattttgg tatcacagct taaaggtact cttaagagaa 71880 agctttacaa atggggcaac ctgaaaagac acatttcatg tgcattcaaa ttcaagataa 71940 gacccaaagc tctgttgcca aggtaaaggt tttgagagtt aaatgggaat ttggaaaata 72000 atatgcaaaa attgacttaa aatgtagata agcctacaag tatttacagg gtggagacat 72060 cagagaatgt aagaaatagt ttggatcact aacaggaatg tgtaatggga agtcaaaatc 72120 tatgctgtca ggaaaaattc atattattgg atagaaactg tattatttgg tacatttaag 72180 ataaaatgaa aattgtgttt tcaaagggtt acgcctcgca gtggatgagt gattggggcg 72240 ttttctggtt tcagtgattc tgtaggcaga aaacagtttt tactgccaag tgtgtcagtg 72300 gaggtgggga gacagagacc ttgctgtgtt aagtgaaatc tgttgcttaa gaataaagct 72360 gggatttctg tagaatggag aaggagtttg gtattatcat attatcaaaa ataactgctc 72420 tttgaaaagt agatttttta aagtttgatt atcaagtatt tatttaaaat actgcctaag 72480 tatttaaaca ctttcaggct ctgattttgt tttttttaca aaggaaacct atgcctaaaa 72540 attattttaa gtagttatat ggatacatga gctacacagt ttcagacctg tgtatatgac 72600 tttctaagag gtctatggta tccaataata aatgatttta tgcagggatt taacacataa 72660 tgggtcatgc attatctata ccttgttaat gggatctata tagagtgata gcagaaaaga 72720 aagttaattt taggatcctt taatgcctat aaatttagag caaaagaaat atttctaaaa 72780 gttcaacttt tgtatacata tgcccaatca caagttttac agacattttt acacgtttag 72840 gcctgaaata tttgattccg ctcttatttg tcaagataca atataattac attagtaaaa 72900 tgcaaacagg gcagataagt tttccttctt tttcctatgc tatagtcatg ctgcaaaccc 72960 tccattacag ttttttggct gaggtaggtc tagatgtcta gaggccaact aatacagttt 73020 tatataatca acatagggaa gtcatttcag agactggcat tgagctcttg gagggaagaa 73080 aatgaacctt aaagcttctt gggaatatcc ctcactgcag cagagtttat gtgctctaat 73140 ggatgctccg taaatgcttg agagaatata agtcccatag gttagcatat acttaattct 73200 acctatcatg gaaacctctc catacattct atagctgaaa tattttagga gctcaaaagg 73260 agtaacagaa actaaaggga acaccagctc caagattgga tttttaggct ttctttctag 73320 tgtaacactt cccttcctgt tgggccatcg gcaaccatat cctggctaat tagaagtgat 73380 tttcagggga aaggaagagg tcataagttc ttgcctccct attttccttc ttgttgggtg 73440 ctagtaactt accttaagaa gtaatgaagt cctagtaaaa ctcctaatat tcagaaacca 73500 actctcatta ttcaaacatg ttgaggaaaa aatgtctcct tgcgtcctct tctgcttaaa 73560 actcccccag taccatcaag catggacgga tatatgatag tggcagtatc cagaagacac 73620 accatctatg taacaaaccc tggaaataaa gtatggtata atcctaagca ttcgctcagc 73680 actcttgctt ctgggaattt gctatgagtc agccacaggc atctctgtgt accttcaagc 73740 ccagattagc acgtatggga ggataagaga gaaagtgtac ttcctgaata catcttgggt 73800 agagtaaact aatccttagc taggttgatg acatccttac ccagaattta aaagttcagt 73860 agagactctt cttgaaatgt tgaattttta tttctgcttg ttgccctcta tagatgagtg 73920 aaatgcaatg aagatattca tggctactat aaaaatgcat tagttctttt tggtgagcta 73980 cttgactatc agagccaaat atgtaggtag ttggaattaa atttccaatt tagcatcccc 74040 cttagaaggg tgatggaagc tcccatatct tggtatttct ctttctgagt atctgctgtc 74100 tcactgaggc aacatgctag cctccatgtt gtattatttc acaggtatag aactaagtga 74160 cacattgcca attcccacgc ccccccccca ttttctttga tggaggtaga ttacatttat 74220 aaggtgtaga tattgcttga aggtacttgt tctttcttat aagtaagcaa gaaagagagc 74280 agcaaataat agctaggagg aagatgtgcc cacaccacat tcaggccact tagtctatct 74340 agtaagatag agtgtttcag gcatcaagca tgtactggga gacatgcata cagaaaaaga 74400 acaagcaata gactcctttg agagtgacat ggtaggtctg aagagtgaat gtaacttttt 74460 gtctccatcc cctcagtgat tcattaatta ttcattagct gtttttttcc accaggatta 74520 caatcatttt acctttgctt gccagcctag tgggttatta acagtggtta ctctatttat 74580 ttacacattt tccttgtgta tgttattcat cctgtattag ttcaccccca cccctagtca 74640 ccattctttt ttcttttgtt tggcctttca tggctaccat attaccatgt gatcagaaaa 74700 aaaatgcact ggtgtcagaa ttaggccaac acagacatat gggatggtag gttcatttgg 74760 gttggataga gagctgtttg aaacttgtat acacattttt caatttcaag aagaaacatc 74820 tgcagtaaag gaagaactgc atagtttgca gtggtctaat ggaggtgaac tcaggaatct 74880 cagatgcatt tagctctaca agtctccatt atacaaatga tgttgaatgt ttcatctctt 74940 gctacagatt agttttgggc catcatgaaa aactttcctg aagattaagt caaacttatc 75000 tatgcatgcc ttctttggat acatagatcc acctttgaca gctactctgt ccactaattc 75060 tgtcaagtag gactgagctt tcttgaacac ctctcctttt gttaacaaga aggagaagaa 75120 gaaaattaaa cactcctggc atctgcctgg ctgtgattta gcccttggta aaaagtatta 75180 caaattgaga cggtgccaga ctgctcctgt gattcatctc ttctcctgtc aagaccagtt 75240 gaggcgatgc aattgggaac ctctctagtt tgtgaagaga cactttatgt tggaagcaac 75300 agcataagca caatagtact taggcattca aagcagagag aattggttcc tcctgattgg 75360 gtgaacaatc actgcaaatt aaggtcaaaa gtattgtcaa ccaattcagt gtactaggct 75420 tcttcatcat ttcccatgac ttgttctctc ttaggagaag gtttagcaaa ttggagcaat 75480 tttttttttt aaatcttggt gcagcgttag tgataaaaca caagaaagtt taaggctgga 75540 tatagcatgt gcatctatat caagatgaag atccatagag agatgtgctt gatcttggga 75600 tgctggatga aaatccaggc actgtgttgt gggagcctga tttctgaaag ttggggcatc 75660 attgtttggc ttatgacgtt tataagtgtc aggtacgtct tgtcccacag aatacttgtt 75720 atagctgtta aaggacagat tgtcttcaag acaactggta cccatgccag agtagggtat 75780 attctgacag aaaatccatt tactctcatc tgtaatttat ccccttagtt gaaacatgat 75840 cccagtgtag ggcatttact tttcacactc cgtttaaatc agtgtggttt cttcctacct 75900 taatgaattt tacctcattt ctttgtcttg caaaaaccca gggcagaatg gtaaaatttc 75960 aaaacaaatc tttcacaagg ctggaactag acactctgtt gggtcacatg caagttattt 76020 gcagaagagg aacactttgc atgtgaataa gagaaagcaa agcacttaca ccagtattca 76080 gtgctcttgg ggccaggagt gaggggcctt ccatgtttgc aggacatctg tttgggcctt 76140 aagttctgct acagccccaa gtccttatct catatctgcc tggtgtccta tttttctgct 76200 taaagagtca aagactgaaa ttcttatcct tgtttcccat tcattcctaa gttactttag 76260 ccttcacatg gagccaccat gctgtggccc acagagtgtg ctattcactt aaacttattt 76320 atcttaacct ttttgtgaaa tatggttgca ttctttgact ttccttgctt gtcacagttt 76380 acattaatcc tggaactttt gagtcttaag cgctacatga tagtactctt tctaatggtt 76440 tctaatgtta cacgaatgcc tctctttccc atttcatccc tttctctctg ttggttttga 76500 ctttaagctc tctggctgtt tcatggcaat gattattggt gacagtatta tctattacca 76560 agtgtttctt gttcagtttt gcatagtttc aatgtccttt taagcaagga ttgccaaact 76620 acaggccacc tgtttttgga gatgccattt aattggaaca ctgccatacc cattcattta 76680 catatcacct atggctcctt tctcactaca agggcattgt ttagtagttg aaacacagac 76740 cttatgtacc ttcacctcaa aacctagaat atttactatc tgactcttta cagaaaaagt 76800 ttgctgatct ctactttgaa gaagagaaag tcgtcagata catacaatgc caaagaactg 76860 ctggctatga aagggatatt gtagaattct gcaattttct taaagaatgg aaaacattgg 76920 aaaagagtca cctgtttaca ggtgatttgc atttctatag gtatcagaat aatgtgggtg 76980 cttgtaggtt ggggaaggaa tggcaggcct tctctctctg tcagtatctt caggccctga 77040 agtcatacaa tcaatggatt gcttttcctc ttcacttttc cattttgcca taattttgcc 77100 aagggggagg ttggaagtgg gttaatattt tgcgttagaa gagcatttgg atacatcctg 77160 ataattactt tatctcagat attcttagat tctctctagt gaaggccaca ccttctctgt 77220 gcctcaggct ggcatggccc aactgtgcta cttaccttgg gttcctgctg ctcagcttaa 77280 agggaatctc tttcatatgc ctagagcctt gtttactcag ttcaggtctg taccagttga 77340 caccaagtca aaaagcactt tagacagaag cctgctttga aagtgctagc tagcagcaaa 77400 taagtctggc ttaattctcc cttgagtctg gagatctgat tggaagggta aaagggagaa 77460 agggatgatt tatttgttga ctggattgac tactttatat tagtaattat gaggcaattc 77520 tacccacatt atctcattta actccccata aaaaccctac aagggaggta atatactttg 77580 gaaaactgag actcagagaa attaagtaaa ttgcaaagtc cccatgctat aagcattata 77640 gtctcataag caaatgtcat gagcttcttc tagctttttc ttcatgctca caaaatggtt 77700 gaaggagatc caagcatcat gtttctagtt aaaaagaagg tgcagagtaa aaggcaaaag 77760 gcaaacggac aagccaacca agtttgttct ctttcctaga tgttctactt ggtgacttca 77820 gcttatatct cattaatgtg catcatagga ttatctctgc aagggaacct ggaaaatata 77880 gaaatttgtt tgtgttaagc tgggcacctt gccacctcca taaaaatgtg ctctataggt 77940 acagagcagg agataatcat tattaatagg caacttatag tctctgtttc aagaggtcat 78000 tctggtacct gagaaaattg acaatctctg gtctaaactc ttacaggcct ctcttgcctt 78060 catttaagat gaacttgata gaataaagat tattgttgtt ctctaatctc ctgggtatga 78120 gacagagagg taacagatgg aatgatttct ttctggcttc catagcaaac caaagcatgt 78180 gccagtgaag agtggcaact gctacaaata cttagccaaa cgtggggaag agtgttgatg 78240 ctgtaagtct cctagctatg tcgaggcagc aggtgtctct gtagatcagg gcagcaatcc 78300 ctttggtaag ggcatgaaga gggcacttgg gactactgga ttgcatcatc ttggcagaga 78360 aaaatgtagc atatactgga actctagctg ggtagggaat tgacaagttg aaccacaagt 78420 tgactactgt tcagtcagca ctagctttta tcttccagtc accattccct gtggctcttc 78480 attgatcgtc cacaagctcc aggcctgggt ggtgcctgtt gtgatataag aagggaagag 78540 tgatggtttc caaaatgtga acactcatgt gtacagtttt catgttgata atgaaatgct 78600 agaaggggaa cagctagctg atgcctatgt ctttgtccat acctggctac ccatgacaaa 78660 gttgttgttg ttgtggttgt tgtttcactc caggcacagg cacagagccg caagagtaga 78720 aaacaagaat tccatcctgc aaaagaaaac tgaatccccc ttgcttggtc acttagggaa 78780 tcaagttcag gagggctgga catgttttct gttgctctgt aataggggct gaaacttagt 78840 tcaattatgg tgcttagctg aagcaccatg actgaatctt tttttgagaa ggagaaagga 78900 gaagatttta aaatgaaatg ccataagtgt aacatagtac atatagaggt cacaaacttg 78960 gaaagcctgt ggtgtcttgg aaggtcacat aaatgtgtga aacacgccag ttgcacacag 79020 gcaagcatat gtcccttcta gagaaattat tgccactgag gaatgctggt tctaatctcc 79080 accctccctt cccctcccct ccactcctgt aaaaaccaga ggtttggaat tttgcgtgaa 79140 taactcagtt tgttagtgtt gacaaccagg catgacagta gctcatttgg accctttgtc 79200 caaatcagga aacagcagcc cttccttcat ggcagccctg tagctacgcc agtcgagtgt 79260 gggctggatt tcagccctta ctctcctcct tagctgagac tttgtgccag acacaagctg 79320 cccagctgta gacagtgggc ccagaagtta tcagtgttac atgagcaaaa caaaacatat 79380 ctacgggcca tactcagccc atggattatt attttgcagc ttctgtagct gcggttaaaa 79440 caaagctctg gggccagatc acctgggttt aaatctgggt tctgcccttc aggcaaatga 79500 ctcagtattt cttggcctca gcctcctcta tctgtaaaat gaagataaat acttgtactt 79560 acttaacagg gttgttacga ggataaaatc aatactgtgg ggcaaacact tagctctaca 79620 gagggtgaca catagcactt aatgttatat aataccaaaa tcatgtgaaa atctgatttt 79680 ttcacactta gagaatatac agcatataaa atgatgggag agtgcatgtc agaccttcat 79740 gattattttc tgcttcttgg ggaaatgctt atgcctcttt ggtcactgtg aagacagaga 79800 actcaaaata gtaagcatca cttactagct ggcctactaa ggccacaaga acaaatgaag 79860 taaacactct gcttgaacca ctgattttgt ttgcctgcat gaaacacttg cacaggttga 79920 cagctgacat ccgtaacaat gacatcctaa aaccattaag aaatgattaa attaagttca 79980 gtattatctg ttgcaaaaga caaagatgtg tgaggtacgt tttagaataa cttacaatga 80040 aaacaactaa aaagtgagga agtttaaagt ggtgagtatt caattgcttg agttcatctt 80100 ctacactggc tcattatctg gaagctgggc cacagagtta atactccatc tttaaagact 80160 gtcacaggtg tttgcaccta agatgcatca ggttctgcag taaaaatttg gttcctggca 80220 ctgagacaat gctaggagga gggtgttaac ttagtactga ccataatgaa atctgtggtt 80280 gactgcaagg acctgggttg aaataagact aaatccagta gtattgctcc ggtaggttca 80340 atcatattca agtgttcaat aatgattata aagaagtgtc aagctgtcat gcttacttta 80400 aaacatatcc agaaaagaga atccaaggaa gtgtatttag ttctacctgc atttaaatta 80460 gctttttttt ttatcattac atcaatgtca ttaggcccta aatgatatta agagtgtcta 80520 tgagacccca aagacaaaga ttgtccccta aacttctatt cttatttgtt taacatggac 80580 ttggcccagc tacctccaat ctaaagcttc tttctctaga gtaaggtatc tcaatctatg 80640 cactgttgac attttgggcc agataattct ttgttcttgg ggctaccctg tgcattttag 80700 gatgtttagc agcatctctg gtctctaccc actagatgct agtgacttcc ttcccctcaa 80760 ctcatgacaa ccaaaaatat ctgtatacat tgctgtaatg tcacctgggg agaaaatctt 80820 cctggtgaga aacactactc tagactaaga aaagtagcca gatttttaaa cacaaaagtg 80880 tttttcctcc cagaggcaaa aagtgcccta gagatggaag aattttgaaa ataagctctt 80940 ccacaaacta tactgccaaa atggttagag aaagatccta taatcaccat gcttgacaaa 81000 tggtgttttt gctaagcctc acagcagctt tgttcatgta ttgtgttaat tgcaattaaa 81060 taaactagtc tagaagtgcg ggtcatcatc cagcccattc atatccctcc tttacagtac 81120 acatccagac ttctttcaga gttttgcttg cccattggtg ctcacatata aaaactccgt 81180 gggtgggagt tagggattca tagagcagag agggacctca gctcttcatg tccacttttc 81240 ttgttttaaa ggacaaggca ctgaggtcca gaaagtggaa tttgcagcac aaattgctat 81300 gataaacctc agtgattcag cccctgggat cttcaatgat ataggcacag aacatataac 81360 tattactgag taaaatgttt aaaattatgt tcttatggca atgttcaagg ttttaggcat 81420 aagtaagaca aagcagagaa aaaataaaaa atatttttca aattgaaggc ttaaaaaatt 81480 aaggataccc tctatgtgcc ttctgcttta ggatccagaa tcttatgttt gtttgctctt 81540 tataacacat gactgtgtaa tatcagtcaa ttgtgactgg taaatttcca ttaatttgcc 81600 taatcatatt tagaaattat gcctactaaa taaattatgg ttggaacttg aaaggaataa 81660 tggcttaaat aagtgatttg ttctttagtc agaaaaatat tctcacgctc tctctcatac 81720 cctcatgaag cactgtcatc tccatctagt ttataattaa ggcaatggga ccaaagtcat 81780 cctgttggca caggatggcc atctctgcat ccaaatttct tttactaatt ggagaaaacc 81840 actaattgta cattttaaac tcaaaatgtc tttatgtata tatatattta aaatatattt 81900 tattattttt attaatttat taattataat tatatttatt aaaataataa ttatttttat 81960 taatttatac atatgtataa tttatgtttt ctccatgtgg ctagctgttg atctaaagga 82020 gaaggagcaa ggcaggaaaa ttatcaggtt cagtgtttaa ctgggagatg aggacatcac 82080 taaaagaaag gtacagcagg ttctactggt atgtacaagt tttgattaca aggtgtactc 82140 ttgccacctg gtgtggtgtc tcagctaact ttagtttctg attaccgggg tctctgagac 82200 aactctccag ggtcaggtat agagctcctt ttgcccttgg catgttccaa atcgcttcct 82260 tatgctcaac cttctgagca atacaaggaa aaattccttg tattggcatg ttatgaaggt 82320 tattgaaata ctttaggaaa tgcctttgac cttgttttgt acttagagga tgatctcatt 82380 cagaaatggg tagtgtcaaa atatggaatg tgctagtaaa ataagcacac aattcactta 82440 aagaaacaaa aacaagacaa gacaaaacaa aacaaaactt gtttgggatg ggtgaaaggc 82500 atggggctgc aattcatcct ggattttaag gttagaagtg gttgaaagaa atgtgatatt 82560 tttacctaaa ccgtggtcaa ctatactttt actttttagc aatgatgtga atgaagaatg 82620 gctttgaaga ctgttggtgg atttgacaaa tatttatcaa gagcctgcta tgagtgtcac 82680 cattataggt ggtagagatt ccacaatgaa caaaacagag tcctttctta cattttgtga 82740 agggagacca cctctaaaca aatatatatc atgtcaggta gagataagtg ccatggggaa 82800 aaacaaaata gggtaagggg ctaggtgggg caggatcaga ccaaggaatt tatattttat 82860 ataagattgt cagggaatgc ctctctaatt agatgacttt ttttttaata gaactgaagg 82920 acataaaagg acgaggctta tggatatctg ggggaagatg tcagaggctg ttataaaagt 82980 tgcaacagga aactgattag gactcttagc agacttatat gtgcttagaa tgaaagggat 83040 tgggataaaa gaaaagaggg gagctttggg aaagcattaa actgtggcca tagcactgat 83100 tggataaacc ataacattgg attatgggtc tgcaaatttc ttacattttt tttaaagtgt 83160 cagacccata gccctagtaa taagcaacat ggtcttttct ttgagcatag ctgtaatgaa 83220 catgttattc ttttggagtt atcctgcaaa gcttatcaaa ctcaagaagc aatagtttat 83280 atgcattgcc caggttgaat attattaatt tgggttggga agtgatatga ccacattctg 83340 actgactata ggccctagtt cagtttacct gattttatgc ccaattttta atgagaaggg 83400 agcttgctag gccaggcagg aagaaagaaa tggggacagt gtcaagcagg aaatgcagaa 83460 gagttgagtg taggtaaatc ccatctttcc tggctttacg ttgccttcac atccctcata 83520 atgatcttct acctcagtct tcagtataag cagtatgttg ttctaaaggt atgaagtctt 83580 ggccaggcac cgtggctcac gcctgtaatc ccagcacttt gggaggccga ggtgggtaga 83640 tcacgaggtc aggagattga gatcatcctg gccaacatga tgaaacccca tctctactaa 83700 aaatacaaaa attagctggg agtggtggtg cacacctgta gtcccagcta ctcgggaggc 83760 tgaggcagga gaatcgcttg aacccaggag gcggaggttg cagtgagccg agatcgcacc 83820 actgcactcc agcctgagaa cggagcgaga ttccgtctca aaataaaata aaataaaata 83880 aaagtaaagg tatgaagtct tttccaagct aaggcaagaa tgctgaaacc tcaatcatag 83940 cacttttcca aaagagtctt accttatatt ctggatctct tcattatctc aagaggggct 84000 tctttctctt taaatgtgaa aagaagagag gcatcagcta gccctattag cccagggcta 84060 agaattgctc cagatttttg aatgcttaac cttaaacaaa gtcacatgta ccagtggaaa 84120 gtggctcccc tgttttcaag gacaggtcag attttaacta cgtgcctctt aggcttgccc 84180 tgtcttcgga gttgttaaac atgcatgttg ggagctgttg actgtttttt tttttttttc 84240 tttctttctt tttttgcctt ataatttact tttattttaa atctattata ctttgaactg 84300 ttgactgtta gagaaagcag tactggctta ggatcagcag agaatatggt tgaattctat 84360 ttcttaaact gaggagaatt tctgtttgag cccagtccaa gtcattactt gagcaatttt 84420 ttgcgcattt tgctgcttaa gtgtttattt tttttttgct tttacaagta atttttttta 84480 aaaaagttat catacactca gcaaacattt tttgagcacg tacacaatgc ccagccctgt 84540 gccatgcatg ttcaaaaaaa aaaataggta acattatatc tgtgcttgtg aaattaatac 84600 atttgttaga aagataagac ttcaatcagt aaagcaatcc aagaaggaac aagtacaaat 84660 ccaggaagga gacattagct cagtggaaag agtccactga ggtaggtaga cttgggtttg 84720 agtcagaagc aagagattgc ttttgtgaga tttcgcttat cctgtgtggg cctcagcttc 84780 ctgttatgta aaatgggata atagtaccta ttacattgtc acattggatt gctgtgatga 84840 cttgataata tttatataca aagcaaccag tataatgcgt gctcatagta agcacttatt 84900 atattattat tatttattgg acatataatt agaaggtctg ggttataatc ttgattctac 84960 aattatttag ttttggtaag tcacttaact ttatcatacc attcatgcat attacctata 85020 aagtgaaagg aacagaggtt ctacaattta tctcccaaat tccatggtat tttgaaccaa 85080 aatgtattga ataagtattt gatgtttgct tccccttctt gttagtgata tttacaatag 85140 caataaaaca tcaatattta tttaggactt gctctggagc cacgagccgt ggtgtgttct 85200 tgacattatg ttatttactc catgctgcat actcagtgag acagataacc ttgtcttgtt 85260 tcctagatcc taggccatat tttatccagt ttaatatttc tgaaatcaga atgtattatg 85320 tagtattatg tagttaataa atatatttaa tgtggaattt ttttcccaaa agccctttct 85380 aagtgagatg gaccctctta tgatttaatg aggatgtctt ccaagggaaa taaatatttt 85440 ttctatattt ctgatggtaa agttgaagca tagagaggat aatttacatg accaagatta 85500 atgaactaac aaaagcaaat tcaggacttg aacttaggtt tgttttattt aacaatgctc 85560 accctaccgt acttcttggg agcaaaaaat ttaaaaagtt tctaacatat attcattagt 85620 tctttccatt ttttatagca aaatatattt gatctgtctc tagaatcaat gatagattca 85680 ctatttgtta acttttaaca ggaatatatt ttagtccctc tagcctgact ttataggcta 85740 tgtacccagt acatgaaaat atatagtagc ctcagtttaa tgttgatgtt tatttgatgt 85800 cgacatcact agtgacactg gtcaagcgta tccttttaga taagagccta ttagaattat 85860 atattccctg tagaaatctt accttgacca tagtacattt aacagcagat ttttctcaga 85920 ctttcaaaat cctgaaagtc tgggtcatta caagaaaaca aggatgtggt cataaacagt 85980 tgattattaa gcaaattcat tgaaaattaa cagcagtatt ctttgacctc actctttata 86040 gccaaactgc taatcttggg taaattataa gattatatta ctaatccatt gacatttagc 86100 acaaattagc tatcaaatgg gtcagttgtt actgttggaa acttatgaaa atacattaaa 86160 gttcttccca tttcctgtat gtttctttct ctgacacaga atcttagagg cttttattag 86220 gctgggagaa cttcccaaat aatctaatga ctagttgaat aattgtttat gatataaaat 86280 cagctttgtt gtcagaatga ttacagtttc agggtcatag ttaatagaaa aatatttcag 86340 tgaaggttac cattagtcgt tgtaagtatc ccttgattca agaagtgaaa cttttattga 86400 aaaaactatt tgcagagctg gagccctgat gggcctttct gaagttttta aaattaagaa 86460 atcctatctc tacttttaac aagacatgaa tgttagtata ttcacccaga ctaaatgaat 86520 gaatgaatga tcacattaca catgcttggg atttgatttc cttcctctgg tgttcactgg 86580 actagcagct tcagtactca agtgcgattg taaaattaca catggtggaa ttcaaaatgg 86640 tgtacatcag tcaggtcctg gaaagacaca caatctaact cagaagtttc aagagacttc 86700 aaggggaaat gtacagaagt atgggtagga ttaaagtagc tagcaaggaa tgctgagtca 86760 ctcggaccct agctgccatg agaagctatt atctcttctg gacctggagc tgcagaagaa 86820 ggaaaccgtg ttactctagt cctgagaggg ccggagccat ggaggagggg tcttgtgaca 86880 gaagctaaag ttctggagag acataggcta ggccagagca taggaatgtg gggaagacat 86940 ccctgacctc tctgtcaacc ttctaatctc cattgttcaa acccagtagg aagttatcca 87000 gcattgagcc tggagagtca gcccgcagca gtcagcctcc tgagtgcaga gcagaggaag 87060 acctggaatg gatatgctat aggaggaggg ccaaacagag agtaactagt ccagatggga 87120 aatgctattt tagacctcat acactgccaa aaaagaatgg catattcaag gaatccagga 87180 ccttgacctc atttgatctt ggatttgcat ccattttctg atactttctt ccaaatactc 87240 ttgtaagcat ctgacagcag ccaggagaat tgctggtcag ttcagcctgt cccagcttca 87300 ttgctgaggt acatatgtgg ttaaggagct gagagaactg gtctgatagc tcaccaaagg 87360 gggcctttcc caaggaaaat aaaataaaga gaaaattcat tgagaatctg tccagaaagg 87420 acagtaagta ggcatggaat catagtagta aggaagcatg gaggaggcag gtgcataaaa 87480 atgacttgtg atatttttga agctatatga taatgttctg acccacactc ttgccagcct 87540 ctgcaatctt ctggaggctt catatgaaag caggattggt atgctgttta ttataaatag 87600 tgagacctga gagatgatta ctgtcagcat aaatggatat tacacattgc acctatctcc 87660 cagcaggaag tttgtttgtt tgtttgtttg ttttagacgg agtcttgctc tgtcgcccag 87720 gctggagtgc agtggcacga tctcggctca ctgcaagctg cgcctcccga gttcacgcca 87780 ttctcctgcc tcagcctgcc aagtagctag gactacaagc gcccgccacc acgcccggct 87840 aattttttgt attttttagt agagacgggg tttcactgtg ttggccagga tggtcttgat 87900 ctcctgacct tgtgatccac ccggctcggc ctcccaaagt gctgggatta caggcgtgag 87960 ccaccgcgcc caaccagaag tttgtgtttg atgtcactgt tgtttcacca atttaaaaga 88020 aaatgaatat ttttaaagga aaagaaaaaa gttatcacac tatgtgatga aatttgtatc 88080 tatgggtggt tatttgctac ttggtaaata attaaagcct gtactggtta cctttccttt 88140 agcagctgac aacaaataaa catcctcacc tcacacctta tacactttac tccatggttc 88200 attttcagta ttattttgta cttctcttgc ttcatcatac tattgcctgg caaaattcca 88260 acccagattt aatcctgctt tccatctata ccctgcctac acctgagagt tcaatgttac 88320 tgtggaaaat gcacactgtg gtgacttgtt tcactttaaa tgcatgggcc ctaacctcac 88380 tgagccattt attagtaatg attggcaact ctccatattt cttgaatcca ctcactttcc 88440 tagtctcctg gacaactatg tgacaactcc tctatcctca agcctccaac aattacttct 88500 cataccctaa ctctgcgcag ataacctttt ttcctatttc actgcaaaaa gcccagaagt 88560 aatcaaaagt gaatctacaa gcttccacca ccacatctac tcctcccagt ctcagtgacc 88620 atatggtttg ccttccttct gttaacagag agcttctatc aaagatgaac ctctccactt 88680 ggcactttat ttccctcttg catattcaag gacattagct cagcaatttt ctttctttct 88740 cctttcttgc attatttatt ttctccctcc accagaagtt gtcaccccaa cttctattag 88800 aatgacttag gaagtgcagg cctcaaacct tttttttttt tttttacacg tctacctcta 88860 ttagcactcc ctgctcctat tttaggaatc caggctttaa cgctaacagt tacaaattaa 88920 gccacaagct ttgtaagtat ttgcctgtgc tctagctgct agtgggtttt tggaaaatca 88980 gtatctgatg ggcatttgaa tacatttgct cttgtggctt taaacaatgt ctgtacaata 89040 aaaacttgag aatttatctc ctctgaattc tagacatttc tattcaacta cctagctggc 89100 atttccactt gcatgcctta aaggccctca atcttatctg tactgaatcg atcacccccc 89160 taactgcctc atccgtcagt tatccccatt gcagttggtg acattccatc ctttggttgc 89220 ttgggttaaa aaatgttgga gtcccccttg actcctttct ttctctcatt tcccaaagcc 89280 aattctttgg caaatagtaa ccatttatca cattttccac tgctactgtt ctggtccaag 89340 ccaccatcct cattcacttg gattattgca aagaccttta cctgttctat atgcttttat 89400 atttgctcat ttttctccct tcacccctat tttgctttca gcacagtata tcatctcatg 89460 catctactca aagccttcta atgccttccc atttcatgat ggcctataaa gccctttgtg 89520 atctggttcc ctgaaatcct tgacttcatt tgggcagatg tttctgctat aacgctattt 89580 atgtgttctg taaaactttt tggtctgcaa gatgtacttt gaaaaataac aggtcttatg 89640 gtaaaattac gattggaata gaacactcat atcttataca acataaaaaa ctgtagcaat 89700 aaccaaagca ataatagata ccttgggaga taacaggaag gcaggcagct cagattgact 89760 gaaggcgact caaggaatat taaaaatgca caaaaacagt agcatggaga tgccggctgg 89820 ggagctgaga tgagacagat gaatggagct ctgagccaga gggcctacca caaaagtggt 89880 cataggaaga agttcagcct gccttgagca gatagctttg cctggtggga gagggcgtat 89940 ttcttgggag acacctctgg gtgcaggcgc tcatctttaa ttcccttaag agagctgaaa 90000 tcactgcagt ctgtgcagca gccaacttca gggatttttc ctttcctgct aaggttataa 90060 ttctgttctt gctattctta ctcctcttgc ctaagaaaaa tcttgtttcc atgtaatacc 90120 aatattatcc cactatttac cagtagcata tgagctgctt gctgttacag aaacacatgc 90180 tgtaatagaa cagactgcac tccttgggtc atctttgtta tttcccatgt gtcaggtgag 90240 cacccacctt gtgacttttg ctactggtct ttccctgcct ggaatgcttt ccctccagaa 90300 gtcctcacgg atttcttctt ctatttcagt tctttattta aaaatatttt tcatagtttg 90360 aacctctcta accagctgat ttaaaagaac aacaccaccc caacaacgtt ctctacttta 90420 catcatagtt taattttctc catagtattt atcatcatct gatatattat aatactcatg 90480 tattggctga accacatcca taagtattaa gatccgtgag ggcaagactt gtgggttttt 90540 aaacttgttt tcctcctttg tttttctcta ttatatcttt agtgtctgga ataaggttca 90600 gcacatacaa ggcatttact aaatgttgaa tgaatgaatg aatgaagctc aagctccatc 90660 tacaaacagt cctctgtttt ttgttttttg tttgtttgtt tgttttttgt ttttgttagc 90720 tgttatctgg ctgtttttta ttagataata atttgtcttc ctttacttac tgattttgtt 90780 tatgtgtttg caggtgtgtg tgtgtgtgtt tgtgtgaaag aggagaatga cttttatcaa 90840 acctggtttt atgtcttcct taggatgcat cagagtttca tgctgttcac actacccttc 90900 ggggtattca gacatttaaa gtcttaatat ttcagcaata aagtcttaat atttctggcc 90960 tggaaaaata ctgtgatatg ggttgaattc atctttttgc acccctctat catcataacc 91020 actccctgct cccattctag gaatccaagc tcttatgcta acaattaaaa attaagtcca 91080 cagactgcag atagacccta cgcttgagct gccggtgggt tgctgaaaaa ttaatatttg 91140 atggaaattt gaattaattg cctctttacc ccctaccaat ccctgtgtat ggtcaaaaaa 91200 taggacattc caatactcca cagtgatggc cacagtgctg gtttgtgctg atgttataaa 91260 ggagcaggaa gatggtaatg aactccctct ggtgctggac aaggcttcac aagggtgctg 91320 atgaaaacaa tgtgagaaaa tggactcagg ggttctcaag gcagagaatg gtggggggat 91380 ccaggaatcc acatattcaa agacacaaag aagtacagat ttctgaggtg ttcagggaat 91440 ggtgattcat taggtatggg gctgggggtg gggcacaggg taggcagagg agagagcagt 91500 aggtgtatat gccatgaaga ttttggaatc gatccaacta tacagctatc aaaggttttt 91560 ggtgatacaa ccagattcgt cttctcactc cttacctttc tcacctgatc cctccctggc 91620 ttttccaaac tgtcaactat aaggctgtgt gaccagagag catgcccctg tccccagtac 91680 tcagataagt gcctgacata tatatatata catagacaac ctacttgttt atgtgtctga 91740 acaaactatc aatattcatt tctgcatttt cttttcagca atgcttacac tgtcttcaaa 91800 tcctttaggg ccctacactt gactatcagg ctgcctattg aaaactaact ttacaggttg 91860 ttcattggtt accatgatgg cacaagtaac cattcagtaa cttttttttt ttttttaact 91920 agaattgaaa gctttgatcc attctctttt tctggtctca tttcccttct accagatctg 91980 attcatggtg caacttttgg tggcatcacc ccttaatcca gcaacatttt tgtataccct 92040 gaggttatta ctttgatgtc ctgaacttat ggctctgggg gatatttttt taaaggggtc 92100 agagaaataa ggttgaatta gagagattct tagaagttta tgattaaaac actatcccct 92160 ctgatctgag tcccagctct gccattgaca ggttgtgtat cattagcaat agcaagctac 92220 ttcacatttc tgaatctcag ttgattgagc aaaatttaga taatcaaaga ctactggaga 92280 tgtgatgctt tgacacaaag aaatctacct ctttggtgaa atttcaattg tgtaggagca 92340 gttatttggg agaaaagtgc cctctcacct tcttaaatca tctcctaggg ctataatagg 92400 aaatacgcag cttttgctga gaacccaaat gacattgtgg attatccagc tctagtcttc 92460 tctctcccat atagaggccg gttatctttg tcacttcaca gctcattagc agccccactc 92520 agggccatgg agaggaaata gatgagatga agcttaaata tgtcacattg gttatttctt 92580 agcagctctg ataaaaggct tagcaggggc caggcgcggt actgtacgtc tgtaatccca 92640 gcactttggg aggccgaggt gggccgatca cctgaggagt tccagcccag cctgaccaac 92700 atggagaaac cttgtcgcta ctgaaaatac aaaattagcc aggcgtggtg gtgcatgcct 92760 gtaatcccag ctactcggga tgctgaggca ggagaatcgc ttgaactcgg gaggcggagg 92820 ttgtggtgag ccaagatcgc gccattgcac tccagtctgg gcaacaaaag caaaactccg 92880 tctcaaaaaa aaaaagcttc agcagggtga ggttaaaact caaataaaga ggtctgagga 92940 ttatctgtga tgttagctca tgtgtgttac cttcctgtct tcccttcttt gttcttattt 93000 ctagggatta gttgactgca aacattaatg ggttaaatat aaaaatgact gcaaacatta 93060 atgggttaaa tataaaaaat cttttctatc ctgaaggtct ttgaaaaaat gattttatta 93120 cttactggaa aagaaaaata aaacaaagct tgcttcaccc agaatttatt ttttcttcta 93180 gttaaaatga gcaacttctt taaccagaac tgaccttgaa gacaaatggc taaaataaaa 93240 catttgctga attcactggg cgcatcttac aagtaatttt tggattctgc attgactacc 93300 tacaagtgcc ttctgggtgc aagtccacag gcaagatttg ttctgcaaat cttccatgac 93360 caaggtcacc tctttggatt ggcagaccca gggagtccat attgggaaga taaattcaca 93420 cttcacccct tgttgagatc tccagccttg ctcctctgat aaccaggtct ctcttctgtc 93480 ctattataat ttatgacctt tgaaaagtta cttatatctg gggctattca aactcccagc 93540 tatctatgac catatgcata aatggttcta gatttaaaaa aaaaaagaag ctattcagag 93600 atattgggat accctataac caatataaat gggtaattca gcagaaccag atgctggggt 93660 tgagaaatag atgtggacaa ttggggcagg gcctaagaaa gatcggaggc aaagacagtg 93720 actagatggg gagctctgat aaggtaatgc ccaggcctgt gcttggaatt ctgccacagt 93780 ggggacatta gtgggggtct gtagtcattg cagggtgaga ggaggataga aagaaaagat 93840 tgtgtgaagg tcagtggaag gtcccccatt tcattgctaa gagaactatg tatgcacgtt 93900 ttcctgtgtt tagtctcaca cataattgta cctttaagaa ctgatcacac actgcatttc 93960 cctggcagtt tttggcatct cagatgagga agagtgatgg gcgacaggtg atggtgacaa 94020 ctattaataa gatctgaaag taaacagtct catgaaaggt ggccaggaga gggcagtcac 94080 cttttatcag gagcacagac tgaatttgca aagggtactt aagctacaag actataaagc 94140 atgatgcagg cttaaccaaa atgcagtgtc ttgagcatag tagactctta gtgtatgttt 94200 gctaaatata ccttagctgc tgctgttccc cagagctcat cagagttcca tagaaacctg 94260 gtcccttcca gaaaaccaaa gaatgactaa agaaaagtga ttgcaaatcc agaaagcagc 94320 tttgccttac tggttggtaa cagcaggatt ttcttttcct tgtagtttat tttggcttag 94380 gctagtgtct ctttcatgaa gacagctact atttacaatt gttgttaaca tgtttttcct 94440 ttttcatctc ccaatatact ctcttcctgt cgttaaacac agtcaattta ccaatggaat 94500 ctgctttata agctcctgca ttttcttttt ccacagatgg gattaatgcc attatgttct 94560 atgtcatcca catagtcttg gcttctaggc accaaggtgt tgttctagag gaaagaagag 94620 taatggtcga cacaggcagg ctgagggcta acctaatgat ttcatgcatt tagtggtaat 94680 tcttaattaa gatcccaatt ttattctgtt ggatttagtc tataacccgc tgaaaatcat 94740 tcttgaatta acactgggtg gatataaaag cagaaagcca aggactttgc actgttctca 94800 gctgtagctg tttatttagc tggagaaaat ttagtgggtg gtccaacctt cataaccagg 94860 aagaataaaa tagaggtgta aaggccttgg tggaaggagg gcagtagcaa cctttccatt 94920 tcttcagttt tatcgcagcc tatgaaatta gttccttagg tatgttgatc ttgtaggagc 94980 tagtatttta acatttgctc catcaagttg tttggtttaa atctaagaat aagcccactg 95040 aaaactattc ctaatttgtg aaacgaataa caataataga tgttaataga aacaaagact 95100 tcatttggtt agtttttaga gggggcacag agaatgtagt aacataataa gttagatttt 95160 tgttgttttc tttttcttag ttctttgtag tctttataat ctctaattgg catttgctcc 95220 tgacttttct cagtgtactt ccacatggaa gagacaaaag tctcaaagct ggtgtagaaa 95280 aacccttaat aaattgccca ttaattagcc accttgattt ccacctttaa agcagttaat 95340 tgaagtaaga atttgttaga tttttctcaa gcatagcaga aattaagatt aatttcttag 95400 gtgtcattgc tacttgccta cttaaaccac cagttcatct ttatcataaa tacttaagcc 95460 aaaagtcaca ttagaggcaa tatggcacag tgattgtgga ccccggagtc aggtgagctg 95520 gttgaaatcc tggcttggct acttcccagc tatgtgatcc tgggcttcag ggttcccttt 95580 tgcaacatga catgattgct gagctgcttc ttagggttgt gtgtggctcc ggtaagataa 95640 tacaggaaaa gagctgaaag cagtatctga ccctggagag aaagtaggga agagacaata 95700 gaggaaagag gacaaggaag tgggagatga agagaaagtt caagaaggaa agtggaagaa 95760 tctcaaatag aaagttaatt ttcagttttt cctgagaaga gatatataga catcttcatg 95820 tggctttgga gagccttgga gcccatcagc aagacggttg gaaattatac tgaaacagaa 95880 gtgtagacct atgtgactta tgtcctggcc agttgcctca tgtcctctgt ggtcaggttg 95940 atctctactg gcactgtcaa aagatttttt atggacagct ggttggggta aactttgaaa 96000 cctgattgtt tgcacttgag tgccagagtg tgtaattatt taccggtgtt cactaaggat 96060 gtcagtgtag atttttaggg ggagaaaaaa cttaaattta aaatttggag gcatcttttt 96120 cagtctgcct gccctggtgt ttgttataac acttagtttg gcatgtaaca gctgaagcta 96180 ctggttaaat cattaagcat ttattatttt aaaactcctc ttctcaaagc aaaaaataac 96240 tatcatgttg aagttctttc ctctaagaat gacatttact gtgagtttta taccaatgga 96300 ctaattggag ggttgagaaa ataaattttg gaaagacaac aataacttca gaattttcct 96360 tggatggagg tttccttttt aaaacctgaa ctgagcttta tcaaaacagt aactgaactt 96420 tgaaacgaaa caagagtgct gaattgaaag ctccaggaag gcagggatgt gtctgtgttg 96480 tttatgacta taacctctgg gcctaaatca gtacctatcc catggtaggc actcggtaaa 96540 tactgaagga atgagtacag tatgaaaatt agcatggctg atccttggaa aaaatataag 96600 tcaaaaggga atagcatgca tgtgtaacta aaacatcagt ccacatgctt gaaatgtcat 96660 cactttttta tggtcaggac ctgttttttt ctgctccaat taaagaagaa aattgtaatg 96720 tgaaagaagc aagaagtgaa gtatttggta ttcatgtgtt ttgacatctg cagtaagttt 96780 aaaataaatt tctaaatctt attgtattga aattgtatga gtttcttaag tggtattatt 96840 cattcagact taaagtgaag ttaggttgct gtcactcata gtggactttt ttttttttgg 96900 cattattaaa acaacatgtc ttctgggtgt tgtcttgtat tacaaaagct tgcgtgtttt 96960 ctcttgatgc tgtgccctgt ctgttgccat tgaggggtct aaggaccaaa tgaggtcttg 97020 tttccttcct gatattcttt tgaccagttt agaatatgcc aggtccattc acacaactaa 97080 gcggctcagt tctctcagtt ccctggtctt ctcatattag attgttatct atgagcttga 97140 agtttagaca tgaaaaagaa tggttgtaat cctcttcctt ctctcaccct cttccctttt 97200 tttcttaagt tagccttttg aattcatgat tctaataatt aatatatatt attatataat 97260 atagtatata ttcataataa tgattaatga tagtattaat aattctgtgt gtgtgtgggc 97320 agctactcat acagaggaaa acagattgat tagtggaaat tacattaatt tcataacttc 97380 ttattaaaag agtttgtgtg tgtgttgttg gttgtttgtt ccctttgcaa ctcaacatgg 97440 tcttcttgag gtgtagggaa aacatatgct taggaaacag agccttcttt tctccttttg 97500 gtatggaaga catatgcaaa aagaatgaag gaactaattg tctctagcca gggctctgca 97560 aaaatagtac tggtagagaa aaagctctaa aagaagtaaa agtttatagt gctttctcct 97620 ggcagagtta acctcatctt catcagcttt tcccctgcct cagagaggca gttttggaat 97680 gaccaaagca gagtgcccaa cctctctgtt cagagttagc gagcatttgg atcactctct 97740 ctctctgcct cagtatgagt ggaatattgc atgaccattt ctgatttctg ccatgagcgc 97800 actcggccta gatgaataaa tcctccttga agaaggcggg gcattttggc attcacaaga 97860 aaccatgttg atatctgatc ctcccactgg agaaatgtgg caaagtgaga aagactcact 97920 ctttgggact ccaaaaatgt aaacacaagt aagcatgcaa gctgaagaag tcacttgaaa 97980 tagaaaaaaa aagtgttaaa ctctctgtta gtcatgtgac tttttcttgg tattcgagag 98040 ccaggaggct cttgtggtct aatctggaaa gagtcgctaa tcgctgtgtc accttggcaa 98100 attggttgat ctccctgtgc tggagtgttt agtccagctg ctggatggga tgaaagcaag 98160 acctcactga aaccagatgc tgtctctctg aaaagatttc agcaataaat aatatcgtat 98220 atactttgtt cctggcagca aatactgaac tgctataacc ctctgttttc acttgcttct 98280 aaatttctgg aaatatctcc tttgggcttg aatttttcca tgcttgtctt cagcccaaaa 98340 ctttttggaa agtttgacca aaatttcact tagctgtttt tcctgaatta tgggagaata 98400 agggcaatgc attgtttttc agctcataaa ttctcatttt tcccattatt cctcagaaaa 98460 atagctgcta catttaaagt gtttagaact agtaaaagaa tcttggtatg gtaaagaata 98520 ctggcagaag acaaatttaa gtctctcagt atttccttct aactttaaac atgactgcac 98580 acaatcaggg cacacataaa aagctctgat gtagttttat agatggccaa agagaagatt 98640 ctgcaaattc tctcagtaac tcatcccaag ttaccaagag gcaactttag ctaccatcag 98700 ttgttacctt tctcaaccac ttgctctgtc tgtggatctg atttctaaaa aaatgtcatg 98760 gttatatgtt ggcattgacc ccttatctac attttaaata aagttgacca tttcttttag 98820 gtagccttca tgtgtgatga cctcagtcat atctgctgac ctactagact caaaattcct 98880 ttacagcagg gcctaggtct gtctacctca ccattgacac tgtagtgctc agcagggtat 98940 gacacatgta gtaaaaactg attgttgaat gaattaaatg aacataagta cagttgtttt 99000 tgctgcaatt tgttcattga tttgtccact aagacatgca tgcatgtatt cagtgagtat 99060 cactgagtct ctactttatg ccaggtattg gtatgaatgt tgtgaatatt tctttgcttt 99120 gatggataac acagaagttt tgctgataca caacaaaata attatattat ttgagtacaa 99180 ttactatgcc tatagttgga atattagtcc aatatagcta aaggcaatcc cagggaattt 99240 atcacttact gagcgtccat gatgtgcctg gccctgtgtt aggtactgag aagagatcaa 99300 ttagacagtt tctgcaggaa gtcacacata ggttaacagt gccaagacaa atcctaaagt 99360 acctattata caaggggaac tataataaag agccaggtga gttgaaggca ggagaggtat 99420 cattgtacca caagatacct tgtgatcttg tgtaaatccc ctgaacaatc aggaaaagct 99480 ttatggcata gctttatggt cagagatctc atggggacag gcagttagtt gcaatgcctt 99540 ttatagccac atccttcact ccttaaccct gcactgtctg ccattcattc tctctgtgct 99600 ttcagccttg agaagctggc caaatttctc aggactggaa aataaactgg aatgacactc 99660 aggcacttga tatcaagatt attagggtca tgattgtgtt taagacccta agacctcttg 99720 atgcttttac aagaatgggt actttttttg tccctgtttt cttcttttgc cccaagtttc 99780 aagagcatgt tacagcagca gtataagcat acacaatcaa aggtgattga agtgaggaca 99840 actggctcaa tgagctccag ccacttcaac tctcctccta gtccctgtcc ccttgcccgg 99900 aatgcttcac cctcagactt tgacatagca ggcttctttt tgtcattcag atctcagctc 99960 aactgcaagg atttctctga cctgaagtta catatgtgtc accccttctg gtctccgttg 100020 ctctctatca catcacctat tggactacct ttatagcatt tatctccacc tgattgtgtc 100080 cttttcactg tttttcttta aactttttat tgtcaatttt ctttcactag atgccagttc 100140 catgaagtag gaaaccttta ccactggtct tgagtgctct tgaaagtgta cgtgtgcaat 100200 aggcactcaa aaatgtttat ggaatgatca gctggatgcg tatatggcaa gtggcgagaa 100260 gccaagggaa taggacaaga gtcctattgt gctccttgcc tgaagaaaac ctcttgcaag 100320 aatcataggc tgttcttgag ggtgcctttg ccttggattc gccaaaaatt cttctgtttc 100380 ttttgtgtga aaattttccc ctcatacaca gcaatgggca ctaagaatgc atatatccag 100440 acttttcagg ttacaggatg gcatctcaga tatagtcttc ctttgatcta tatactatga 100500 agccataatt gcttagccag tatctttttc aggatttact ccatatttct tattctaggc 100560 ctttcaggtg gcagctgcac tggctttcag atataattta gaatttagtt tcggatttgt 100620 aaagctactc atgctgcaga tcttctctga aacatttctg tcacatttta gaaagcttta 100680 cattttcatc tgctaacgat tttcatctgc caaagagccc atctacttaa aaagcagatc 100740 actgaagcca cacttggcac atattacttt ggcttatttt cttttgattt ttttgctttg 100800 ctgggattac ttatttatga agaaagagag aatattgact tcttatttta gaagagagga 100860 tattacttgg gttgagagtt ctagttatat aaaatgtatt tatctaagtt gttaactata 100920 tcaaaaatgg agcagtcaat ctttggaaat agttcagggt gaaatgtttt tagcatgttc 100980 acatattctc tttgctgttt ttaaataatt tggcaaagct tatttgcatt tcccaaatta 101040 acaattttgg ccaagaggaa aagctaaagt gttggttttt ctcagctcaa ctttttgggt 101100 gtaattaatt tataagcaag attttatgaa gggagaacag ataggacctt tctacaaagt 101160 ccctgagcca aaataaacac cccattgttc catcgttttg tattgcacat aggaaaacat 101220 ccatccctat cattattctg ttaaagggac acagattacc agatttgtaa ttttaaaaaa 101280 ggccatttgt tgattgagcc actttgcgta taaagggtgg tatatgttgc ctgccgaatt 101340 tctgtacaag aaaaaaatca tatatcaaaa aaatttttct cattcatcat ataagaaatt 101400 tatgcatttt agtatgtacc agaagaaatg gctttggcat tttctgtttt tagcagtctg 101460 ttgaaatttc ttcattaaag acattttctg tttgaaggtt aaaatgacca tataaataca 101520 gattaattca gttttaatag gtgcatcttc ctgtcattta ccactttctc tcctcaatat 101580 cagctacagt gatcaacata tatttagcag tgaaactgat atattctgtt tatcttcaaa 101640 tcataagctt tttgtttaaa tacaaaggaa aatcttatac ctctgatttt aatatgacaa 101700 atcaaaaagt ccacaccaaa ctcccaactc atcccaaaaa agagattgct atctactcat 101760 cactgttctc tgcttctaag atttgtttcc cttggggtta ctgtttgagc aacttttctt 101820 acttccaaga ttgtttttgt ggttttaaga aagaatctga attccaagat tatttttctg 101880 gttttaagaa agagtctgaa aatctagaga ttacttacct tgtggtgagg tggttgtcta 101940 tgcttctgtt caacaaaggc ctcatgtact gaatggaaaa aaagcatcag gacctataat 102000 tttctaggca ttatgcaaga taatagagga gacaaaaatg atgtcttgct tcaaagtctt 102060 agatctattt ccctttgggg gttgaggaat gagaaagaga tttttagatg aaaaacagga 102120 agcccaatga ggacgtgtgg caatagttcc taaaatgagc aaagagataa atttactctt 102180 ttatatgatt acaaccaaat cacacactgg tgagtttcaa aacagtagtt ttcatttaga 102240 aagcaaatta agtggaataa ttcaactgag tttcactgca atgggattca ttctagatgg 102300 ttcaactctg gaattagaaa caatatctaa ggatgttgct gatagtagtc agcagataaa 102360 taccagtaag tcgtatacag gtatacatca ttttattgtg atttgcttta ttgtgttttg 102420 tagataattg tgtttttaca aattgaaggt ttgttgcaac cctgtaacga gcaagtcttc 102480 tggctccatt tttccaatga cttgtgctca ttttgagtct ctgtgttaca tattggtaat 102540 ccttgcaatg tttcaaactt ttttattatt attatatctg ttttggtgat ctgtgatgag 102600 tgacgtttga tgctattatt atgttgtttt ggcacaccat gaattgcacc catataaggt 102660 ggggaactta atcactaaat gttgtgtgtg ttctgactgc ttcactgaat ggctcttccc 102720 ctatctctct ccctctcctc tggcttccct attccctgaa acacaacaat attgaaatta 102780 ggagcgttaa taatgctaca atgacctcta cgtgtctgat atggtttggt tgtgtcccca 102840 accaaatctc aacttgaatt gtatttccca gaatttccat gtgttatggg aggcacccag 102900 ggggtggtaa ttgaatcatg ggagccagtc tttcccatgc tattctcatg attgtgagta 102960 agtctcacta gatctgatgg gtttatcagg ggtttccact tttgcttctt cctcattttt 103020 ctcttgccac caccatgtaa aaagggcctt ttgcccccag ccatgattct gaggcctccc 103080 aaggcatgtg gaactgtaag tcccattaaa gctatttttg ttcccagttt ctggtacgtc 103140 tttatctgca gcatgaaaac aaactaatac agtaaattgg taccagtaga gtggggtatt 103200 gctgaaaaga tacccaaaaa tgtggaagtg actttggaac tgggtaactg gcagagtttg 103260 gaagagtttg gagggctcag aagaagacag gaaaatgtgg gaaagtttgg aacttcctag 103320 ggacttattg aataactttg acccaacagc ctgataacga tatggacaat aaagtccagg 103380 ctgaggtggt ttcagatgga gatgaggaac ttgttgggaa ctggagaaaa tatgactctt 103440 gttatgtttt agcaaaaaga ctggcagcat tttgccctag agattcatgg aactttgaaa 103500 gtgagagatg atttagggta actggcagaa gaaatttcta aacaacaaag cattcaagag 103560 gtgaatgctt gggtgccatt aaaagcattt cattgtgaaa gggaaacaga gcataaaagt 103620 tcagaaaatt tgcagcatga caatgcagta gaaaaggaaa acccattttt tgaggagaaa 103680 ttcaagccgg ctgcagaaat ttgcatgagt agcaaggagc ctaatgttaa tcccctagac 103740 catggggaaa atgtctccag gccatgtcgg agaccttcat ggcagacctc ccatcacaga 103800 cccagaggcc caggaggaaa aattgttttt ctgggccagg cccagggtcc ctgtgctgta 103860 tgcagcctaa ggacttggtg ctctatgtcc cacctgctcc agctgtggct gaaaagggcc 103920 aacacagagc tcaggctgtg gcttcagagg gtggaagccc caagccttgg cagcttccat 103980 atggtattga gcctgtgggt gcacaaaagt caagaactga ggtttgggaa cctccgccta 104040 gatttcggaa gatgtacgga aatgcctgga tgcccaggca aaagtttgct gcagagttgg 104100 ggccctcatg gagaacctgt gctagggcag tgcagaaagg aaatgtgggg tcagagcccc 104160 cacacagagt ccctgctggg gcactgccta gtgaagctgt gagaagaggg ccactgtcct 104220 ccagacccca gaatggtaga tccaccaaca gcttgcactg tgctgctgga aaagccgcag 104280 tcactcaatg ccagcccatg aaagcagaca ggagggagac tgtactctgc aaagcctcag 104340 agtagagccg cccaagacca tgggaaccca cctcttccat cagcgtgacc tggatgtgag 104400 acatggagtc aaaggagatc atttttgagc tttaaagttt gactgccctg cggcatttca 104460 gacttgcatg gaccctgtaa tcctaatcct attgttttgt ccaatttctt ccatttggaa 104520 cagctgtatt tacccaatac ctgttgtatc taggaagtaa ctagcttgct tctgatttta 104580 caggcttata ggcagaaaag atttgccttg tctaaggtaa gactttggac tgtggacttt 104640 tgggttaatg ctgaaatgaa ttaagacttt gggggactgc tgagaaggca ttattggttt 104700 taaaatgtga agacatgaga tttggagggg ccagggccag aatgatatgg tttggctgtg 104760 tccccaccca aatctcacct tgaattgtat ctcccagaat tcccacaggt tgtgggaggg 104820 acccaggggg aggtaattga atcatggggg ccagtctttc ctgtgctgtt ctcatgatag 104880 tgcataagtc tcctgagatc tgaggggttt atcagaggtt tctgctttcg cttcttcctc 104940 atttttctct tgccgccacc atgtaagaag agtcttttgc ctcctgccat gatttggagg 105000 gctcccatac atgtggaact gtaagtccaa ttaaacctct ttttgtttcc agtttcagat 105060 atgtctttat cagcagcatg aaaacaaact aatacagtgt ccaagggaaa ggaaaagtca 105120 catgtctctc actttaaatt aattaagctt agtgaggaag gcatgttgaa agccaatata 105180 ggctaaaagc taggcctctt gcaccaaaga gttatccaag ttgtgaatgc aaaggaaaag 105240 ttattgaagg aaattaaaag tctactccag tgaatacata agttattaaa aaaaaaaaag 105300 tgacacagcc ttagtgctga tatggagaaa gtttgagtgg tctggataga aaatcaaacc 105360 agccacaaca ttttcttaag ccaaagccta atccagagca aggccctgac tctcttcagt 105420 tttatgtaag ctgagagaga aagctacaga agaaatgttg gaagctagca gaggttggaa 105480 atttaagaag ccatctgtgt aataacataa aagtacaaga tgaaccagca ggtgctaatt 105540 tagaaggtgc agaaagttat ccagaagata tagctaagat cagtgatgaa gattactaaa 105600 caacagattt tcagtataga taaaatagcc ttctattgga agaatacgtc aatagaagat 105660 ctaagacttt catagttaga aagaaaaagt caatgctggg ctttaagact tcaaaacttc 105720 aaagggaagg ctgatccttt ttttatgagt tgatgaagtt ggtgacttta agttgaagcc 105780 attctcccca gccttgctag agaaaccaaa agtcaaattc aggaaataca gagaacccct 105840 gcaagattct acacaagaag atcatacccc agacacataa tcatcagatt ttccaaggtc 105900 aaaataaaag aaagaatgtt aaaatcagct agagagcaag ggcaggtcac ctacaaaagg 105960 aaccccatcg ggccaacaac agacctctca gctaaaaccc tataagccag aagagattgg 106020 gggcctatat tcaacattct taaagaaaca aatcttcaac caagaatttc atatccagct 106080 gaactaagtt tcctatgtga aggagaaaga agattcagag aagcaaatgt tgtgggagtt 106140 tgttagtacc agacctccct tataagagat cttgaaagga gcactaaata tagaaaggaa 106200 agacagctac catctaatac taaaacacac ttaaatacac agaccagtga cactataaag 106260 caaccacaaa agcaagccag cataaccagc taacaacaca atgacactat caagttcaca 106320 catatcaata ctaaccctga atgtaaatgg gctaaatgcc tcacttaaaa ggcacagagt 106380 ggcaagctgg ataaaaaaga aagacccaat ggtatcctgt cttcaataga cccatctcac 106440 atagcctcaa aataaagggg tggaggaaaa tctaccaggc aaatggaaaa caggaaaaag 106500 caggggttgc aatcctaatt tcagacaaac agactttaaa ccaacaaaga tcaaaaaaga 106560 caaagaaggg cattacataa tggtaaacgg ttcaattcaa caagaagacc taactaccct 106620 aaatgtatat gtacccaaca caagagcact gtattcataa ggcaaggtct tagataccta 106680 caaagagaca tagactccct cacaatatta gtgggagact tcaacactcc actgacagta 106740 ttagatcatc aaggcagaaa attaacaaag acatttagga cctgaactca acattggact 106800 aaatggatct gatagacctt tacagaactc tccacctaaa aataacaaaa tatacattct 106860 tctcatcacc acgtggcaca tactctaaga ttgatcacat aattggaaac aaaacaatcc 106920 tcagcaaatg caaaagagct gaaatcatac aatttcaaaa atcagagggc ccttaagaat 106980 tatgctaaat ctactctgtc tatactctat aaatggaaca caatacatgt gtaatagtac 107040 acctgtttac agtatggctt gctgaatatt ttaaggccac agttgagacc tcctgcacag 107100 aaaaaaaaga tttttttcta aatattagtc ctcattgaga aagcacccag tgaccaaagg 107160 gctctgatgg agatgtacaa ggaggttaat gtagttttcg tgcctgttaa cacaatgtcc 107220 attctgcagc ctatgtatca aggagtaatt ttggccttta agtcttatta tttaagaaat 107280 acatcttgta aggctatagt tgccatagat agtcattctt ctgatggatc taagaaaaat 107340 acattaaaaa ccttatggaa aggatttacc atcctagata ccattaaaaa catttatgat 107400 tcataggagg aggtcaaaat atcaacctta acagcagttt agaagaagtt gattccaatt 107460 ctcatagatt actttgaatt gattcaagac ttcagtggag aaagccgctg caagtgtagt 107520 ggaaatagca agaaaacttg aattagaagt ggagcctgaa gatgtgactg aattgctaca 107580 gtctcatgat aaaacttgaa cagatgagga atcacttctt atggatgaac aaaaaaatag 107640 tttcttgaga tggaatctac tcctggtgaa gatgccatga acactgttga aatggcaaaa 107700 gatttagaat atgacataaa cttagttgat aaagcagcag ccagatttga gaagattgac 107760 tccaatttta aaagaagttc tgtgggtaaa atgctgtcaa ggagtatcac atgctacaca 107820 gaaatctttt atgaaaggaa gaatcaatca gtgtgtcaaa ctttactgtt gccttatttt 107880 aagaaattat cacagccacc ccagacttca gcaaccacca ccatgatcac tcagaaggtg 107940 tcaacattga gacaagactc tccaccggca aaaagattat gactcactaa aggctcagat 108000 gatgattagc atttttagca ataaagtatt tttaaattaa agtatataca ttgtgctctt 108060 tttagacata atgctcttgc acacttacta gactacaaca gattatacac gtaacttttt 108120 tttttttttt tgagacagag tcttgctctg tagcccagtc tggtgtgcag tggtgcaatc 108180 ttggctcact gcaagctctg cctcccgggt tcacgccatt ctcctgcctc agcctcccga 108240 gtagctggaa ctacaggtgc ccaccacaat gcccagctaa ttttttgtat tttcagtaga 108300 aacggggttt caccatatta gccaggatgg tcttcatctc ctgaccacgt gatccaccct 108360 cctcagcatc ccaaagtgct ggtattacag gtgtgagcca ccgcgcctgg ccagacataa 108420 cttttatata cagtaggaaa ccaaaaaatt gtgtggcttg ctttattgag atatttgctt 108480 cattgcagtg gtccggaact gaactgcagt atcttcaagg tatgtctgta ttcaagttta 108540 tattttgaca tacattcttc tttacttgtt aaaatcatgg tcacctcatt attatatgac 108600 tgatcagaat ttgcagggtt gctttgacca tataccattg ttctacaact acgcagatgt 108660 ctgagtccta aaggtgaatc tgtctggcca gttctgggtt taacggccta tataaaaagt 108720 agatgttaca caccttgtat aactgaagcg ccctatcacg gacacagctt aactcttggg 108780 tgggtcactt agtctgcttg gttgaggttt cagtgctttt cacatctaca gaaatgtcct 108840 atttgtctaa ggcaatttta tgaagtaaat ttactcttgt catcctttcc aacctgaaaa 108900 tagaggatat ataattttta gcattccatt attacctagg ggatggtctt cagtcattct 108960 tccctgaatt tattacactg gccctatctt cttcacctga aataagttaa atgtagaatt 109020 agcactaaag agaaatagaa tgaacttctt ccggaatggg aataggaaat gaaagagagt 109080 aaatcagaag tgaatcactt cttttttttt tttttttttt tttttgcttt gcaaatctat 109140 atttttttcc agctttattt aggtatgatc agcaaataaa agttgtatat attcaaggtg 109200 tatgacatga tgatttgata tatgtgtaca ttttataatg atcaccatga tcaaattaat 109260 taacacatcc ttcaccacac agttaccatt tgtgtgtgtg tgtgcaagag gaggtaaggg 109320 agtttaatca tttttgaaca ctagctacaa cataattcaa ttaaaattct gagaaagaag 109380 aaaaattgtc atgcagctgt ttaattttag aagcattaac tgacaaaatc caagtcttat 109440 gatgaatact cagtcaaatt ttcatgaatg aatgggagcc tttacctctg aaattgttgt 109500 catggaagaa aacactaaca ctgtcttaca cagtaattca agttaccaat tgagttaaag 109560 tagcaagatg agccatggtt gtaattgaga atggcaacta tggtgttctt atctaatctg 109620 ctacctagtt tgcctttttg ctctaaaatg gtgactatgt tagaattcaa agaataaaag 109680 gcctttatcc tttcagggga aatacaagta acaagcttaa tttttttttt cttaacactg 109740 atgaaactca tttggggctg tggaaattgc tgctagcatt gaacctctta ttaacattca 109800 aggtgtgcca gttttgcaca agctgtgtca tattcagaga tagattgttg gcacaaacta 109860 aggcacttat tctcttgttt tttcacttct ttcaataaga acagataaat atactatttc 109920 tagataagca gttgaaactg ttctgctcat ctctttggaa taggtttgtg ggggtatcac 109980 tgtatgacat gccgaagaaa tatacaaggg aaatgctccc gcatacattg agatataaat 110040 gaatgcctat tttagaatac gtcatttctt aaaagtaaaa taagttttgg ctgggcgcag 110100 tggctcacgc ctgtaatccc agcactttgg aggccaaggt gggtggatca cctgaggtca 110160 agagttcaag actagcctcg ccaaaacagt gaaaccccat ctctactaaa aatacaaaaa 110220 ttagccagac atggtggtgt gcgcctgtaa tcccagctac tcagaggatg aggcaggaga 110280 attgcttgaa cccaggtgat ggaggttgca gtgagctgag atagcaccat tgcactccag 110340 cctgggcaac agagtgagag tccatctcca aaaaaaaaac caaaaagtaa aataagtttt 110400 taaagtcact gattctgttt ctaaggaatt ctcagctggg gcttctgagt caattctcga 110460 tggttagaac ttatgagtag cagaaaaaga aaactactat ggattttctc tacaatgatt 110520 tgagacagtg aatggggctt tctggcaggt tagcagttag gaactcagat gaccatagac 110580 tttttttttt ttagagtggg tctcggtctc actctatcac ccaagctgga gtgccgtggt 110640 gtaatcatag ctccctgaag cctcgacctg ggctcaagca atccacagat ttttgaagtt 110700 caccctggat tgttgtgttc tacacagagg ttccaccttt tgctgccttt tatggttact 110760 atattattat tttgatgttt cttaaccagc tgaatcacat tgtagtatat gaaatatgtt 110820 ttggctcttg ttttaatggt tatttgctag cagatttcac aatggcccaa tgaaacaacc 110880 cattcattgc tatttgttgc aattcatggt gactaaacat gactccatgg tacggctcac 110940 caaagtcttg gtttatgtgt gacttccagg ggagagagat tgagaaccat ctgttaatca 111000 ttttgtccct aaactagagt ttttcaatgg agtacttggg cagttgaatt agtatgtttc 111060 tcgtaggcta gtgagaaaaa tagctttttt tttttttggc attaatcaga ctgctgaccc 111120 acatctctgg gaatacttgt gacaagatcc agcctgacaa tatcacatat gatttgcttt 111180 tcttcttgga agggacacat tgtggctttt ctctggaatc tgtgaagaaa atgctcctga 111240 gcctagaaac tggaactgag aaagctcttc ctgatcatat aacaataagt cttgtgaggg 111300 tcaacccttg agccatgagg gcagcttgaa ggaacatggg gttgagagtc aagtcatcag 111360 aacttctgtt tatttttctg tgtaatattt agggacttgt tatgtttaac tctaggcaaa 111420 ggtatagatt tggaggtctt tgatatagat gatagataga tagatagata gatagatgaa 111480 atatatttta gcatacaaag gaggctacaa tacacactca tgtacctgtc actccaatga 111540 attcatcaaa tgtaaacatt ttccccaaat ctgcttctta gctgttattc gtaaagaaac 111600 aaattgtaca gaaaaatttg aaggcccccg ttttaccttc cccagtctca ttattttctc 111660 tgccacccca gagaaaacaa ctgtcttgca taggtattta tataattctg ttttatactt 111720 tgccactttt actacatata tgaagcatgc ttgttacata catgaacata aaatatacat 111780 gttttactgt aagtgtggaa tgtattctag aatttgctac ttttactaca aatattttat 111840 tttcagaatt tacccttgtt attatataac cctagttcat tttttaattg ccatatatta 111900 ctccatctta tgaaaatacc acaatttatt tattcccata ctaatcagaa tttgaattga 111960 tacaattttt aattaaaatt aataatgctg aaagaaatgt tctttttata catttccctc 112020 agggtgcatg tgatagagtt cttctcacat atatatcagt gtacttgctg tgtcttagga 112080 tatgtacaat tgcatgtcta ttagatatgc caaattgctc tgcaaagtac tcataccagt 112140 ttccactcct accagcaatg aatgagaact ttgtttcgca ggtcattgcc aacacttgat 112200 tattatcaga tttaattatt tgccagttga tggatgtgaa ttgctctatc actgttttaa 112260 tattcattac tttgattatt tataacatta ggtatacttt tcatagggcc atttaaattt 112320 cctctcatct gaattgccta tttctcctct tcgttgattc ttctattatc ttttcttctc 112380 tttattaatt tatagaaatg tatgtgtgat cctaatatgt gtcataatat ctatgttcat 112440 atttcatata taaatataat gaaatacttg tctctgttat atataggttg aaaagtttgc 112500 tccctatctg ctgattgcat tttaattttg ttcatggcat cttttaacac acgtgatttt 112560 taattttgat atagttaata ttttttatta ctctagattt tgagaattgc tcaagaaatg 112620 actttatttt gcatagtcat atgctctaat ttttttaatc tacttacaat agttttatgt 112680 taaatatgtc aacctttgtt tcacccggaa ttttttatat gtatggtata aagcataaat 112740 caattttttt tactattgag aatgctttta ttatattata tcttattcta ttctattttt 112800 atttttccat aagttattgg ggtacaggtg gtatttggtt actttagtgg tgatttgtga 112860 gattctagtg cacccatcac ccaagcagta tacactgcac catatttgtt ttcttttatc 112920 cctcatcccc ctcccaccct tcccccaaag tccccaaatt ccattgtatc attcttatgc 112980 ctttgcatcc tcatagctta gcccccacat atcagtgaga acatatcatg tttggttttc 113040 cattcctgag ttacttcact tagaataata gtctccagtc tcatccaagt cactgccatt 113100 aattcattcc tttctatggt tgagtagtat tccatcatat atatatagta tatgtatgta 113160 tatatatgta cgtatgtata tatgtatata tgtaagtata tatgtacgta tgtatatatg 113220 tatgtatata tatgtacata tgtatatatg tatgtatata tatgtacata tgtatatatg 113280 tatgtatata tgtacatgtg tatatatgta tatatgtata tatgtacatg tgtatatgtg 113340 tatatatgta tatatgtaca tgtgtatatg tgtatatatg tatatatgta catgtgtata 113400 tgtgtatata tgtatgtata tatgtacatg tgtatatgtg tatatatgta tgtatatatg 113460 tacatgtgta tatgtgtata tatgtatgta tatatgtaca tgtgtatatg tgtatatatg 113520 tatgtatata tgtacatgtg tatatgtgta tatatgtatg tatatatgta catatgtata 113580 tgtgtatata tgtatgtata tatgtacata tgtatatgtg tatatatgta tgtatatata 113640 ctatagtttc tttatccact cgttgattga tgagcatttg ggttggttcc atgatttttc 113700 aattgcaaat tgtgctgcta taaatgtgtg caagtatctt tttcttataa tgacttcttt 113760 cctctgggta gatacccagt agtgagattg ctgaatcaaa tcgtagttct acttttagtt 113820 ctttaaggaa tctccacgct cttttccata gtggctgtac tagtttacat tcccaccagc 113880 agtgtagaag tgttccctga tcaccgcatt catgccaaca tctactgttt tattattatt 113940 ttttttatta tggccatcct tgcaggagca acatggtatc acattgtggt tttgattgca 114000 tttcccttat cattagtgat attgagcatt ttttcacata tttcttggcc atttgtatat 114060 cttcttttga gaattgcctt agcccacttt ttgatgagat tgcttgtttt tttattttct 114120 tattgatttg tttgagtttg ttatagattc cagatattag tcctttttca gacgtataga 114180 ttgtgaagat ttttctccta ctctgtgggt tgcccattta ctctgctgac tgttcctttt 114240 gctgtccaaa agctctttag tttaagtccc aactatttat cttttgtttt tatttcattt 114300 gcttttgcgt tcttggtcat gaaatccttg cctaagccaa tgtctagaag agtttttcca 114360 atgttatctt ctagtatttt tatagtttca cgttttagat ttaagtcctt aatccatcct 114420 gagtagattt tttgtatgag gtaagagatg aggatccagt tttattctcg tatatgtgac 114480 tagccaatta tccaagcacc atttgttgaa aaggtgtcct ttccccactt tatgtttttg 114540 tttgctttgt ctaaaatcag ttagctgtaa tatttggatt tatttctggg ttcaatattc 114600 tgttccattg gtctatgtgc ctattttcat accaatacca tgctgttttg gtgactatgg 114660 ccttagagta tagtttgaaa tcaggcagtg tgattcctcc agatttgttc tttttcctta 114720 tttcttgctt tggatatgca ggctcttttt tggttccata agaattttag aattgttttt 114780 tctaattctg tgaagaatga tggtggtatt ttgaaggaga aggttttgaa tttgtaggtt 114840 gcttttggca gtgtgatcgt tttcacaata ttgattctac ctatccatga gcatgggatg 114900 tgtttccatt tgtttggtca tctacgattt ctttcagcag tgttttgtag ttttccttgt 114960 caaggtcttt caactctttt gttaagtata ttcctaagta ttttattttt tatttttttg 115020 gcagcaattg taaaaggggt tgagttcttg atttgattct ctgcttggtc gctgctggtg 115080 tatagaagag ctactgattt gtgtacatta atcttgtatc tggacatgtt gctgaattct 115140 tttatcagtt ctgggaactt tctggaggat tcttcagggt tttcaagtta aatgatcata 115200 tcatcagcag acagtgacag tttgacttcc tttttaccaa tttggatgct ctttatttct 115260 ttctctcatc tgattgctct ggctaggact cccagtacta tgttgaagag gagtggcgag 115320 agtgggcatc cttgtcctgt cccagtttcc agagggaatg ctttcaactt ttccccattc 115380 agtattatgt tggttgtggg tttgtcataa atggctttta ttacattgag gtatgcccct 115440 tgtatgccaa ttttgctgag agttttaatc tgaaagggat gctggatttt gtcaaatgct 115500 ttttctgcat cttttgagat gatcatgtga tttttgtttt taattctgtt tatgtggtgt 115560 atcacattta ttgacttgca tatgttaaac catctctgtg cccctggtat gaaacccact 115620 tggtcatggt ggattatctt tttgatatgt tgtcagattc agttagctag tattttgtta 115680 aagagtttag catctatgtt tatcaaggat atcggtctgt agttttcttt tttggttatg 115740 tcctttcctg gttttggtat tagggtgatg ctggcttcat agaatggatt agggagggtt 115800 ccctctttct ctatcttgtg gaatagcatc aaaaggattg gtatcaattc ttctttgaat 115860 gtctggtcaa attctgctgt gaatccatct ggtcctgggc tttttgtcgg taagccttta 115920 attaccattt ccatctcact gcttgctatt ggtctgttca ggttatctaa tttttcctga 115980 tttaagctag gagagttgta tttttctagg aatttatcca tctcttctag gttttctagt 116040 ttacgtgcac aaaggtgttc atagtactct tgaatgatct tttatatttc agtggtgtca 116100 gttgtagtat cccccatttt gtttcttaat gaggttattt ggattttctc tcttctattc 116160 ttggttaatc ttactaatgg tctattgatt ttatttatct tttaaaataa ccagcttttt 116220 gttttattta tcatttgtat tttttctttt aattttattt agttcttctc tgttcttggt 116280 tatgtcctct cttctcctcg gtttgggttt ggtttgtcct tgtttctcta gttccttgag 116340 gtttgacctt agaaagtcac tttgtgttct ttcagtcttt ttgacatagg tgttagggct 116400 atgaactttc ctcttagcac tgcctttgct gtatcccaaa ggttttgata ggttgtgtct 116460 ttactgttgt tcagttcaaa gaatttttta acttccatct tgacttcatt tttgacccaa 116520 tactcattca ggagtaactt atttagtttc tatgtatttg catggttttg acggttcctt 116580 ctggagttga tttccaggtt tattcaatgt ggtctgagag agtacttgat ataatttcaa 116640 ttttcttaaa tttattgagg cttattttat ggcctatcat atggtctatt cttggagaaa 116700 gttccatgca ctgttgaata gaatgtgtat tctgcagttg ttggatgaaa tgttctgtat 116760 atatttgtta agtccatttg ctccaagtac agtttaaatc cattgtttct ttgttgtctt 116820 tttgtctgga tgacctgtct agtgctgtca gtggaatatt gaagtcccca ctattattgt 116880 gttgctgttt ctctcatttc ttaggtctat tagtaattgt tttataaatt tggaacctcc 116940 agtgttaggc gcatatatgt ttaggattgt gatattttcc tgttgcacaa ggctttttac 117000 cattatatag tgtccctgtt tgtctctttt aactgctgtt gcttcaaagt ttgttttgtc 117060 tgatacaaga attgctaccc ctgctggctt ttggtgtcca tttgcatgaa atgccttttt 117120 ccaccccttt actttaagtt tatgtgagtt cttatgtgtt aggtgagtct cctgaaggca 117180 gcagatactt ggttggtgag ttcttatcta ttctgctgtt ctgtatcttt taagtggagc 117240 atttagggca tttacattca atgtcagtat gagatgtgtg gtactgttgc attcatcatg 117300 ctgtttgctg cctgtgtacc ttggtttttt gtttttggtg tttggttttt aacttgtatt 117360 tttgtttata agtcctatgt gatttaggct ttaaagaggt tctgttttaa tgtttccagg 117420 atttgtttca agatttagag ctccttttag cagctcttgt agtgctggct tggcaggggc 117480 caattctctc agcatttgtt cgtctgaaaa tgactgtatc tttccttcat atatgatgct 117540 tagcttgctg gatagaaaat tttggactaa taattgtttt gtttgaggag gctgaagata 117600 ggggcccaat cttatctagc ttgcagggtt tctgatgaga aatctgctgc taatctgata 117660 gattttcctt tataggttac ccagtgcttt tgcctcacag ctcttagaat tctttctttt 117720 gtcttaactt tagataacct ggtaacaatg tgcctaggtg atgatttctt tgcgatgaat 117780 ttcccaggtg ttctttgtgc ttcttatatt tagatatcta ggtctctagc aaggctgggg 117840 aagttttcct caattattcc ctcaaatatg ttttcccaaa cttttagatt tctcttcttc 117900 ctcaggaaca ccaattattc ttaggtttgg tcgtttaaca taatcccaga cttcttggaa 117960 cctttgttca tattttctta tttttttctt tgtctttgtt gaattgggtt aattcaaaga 118020 ccttgtcttc aagttctgca tttctttctt ctacttgttc aattttattg ctgagacttt 118080 ccagagcgtt ttgcatttct ataagcttgt ccaatgtttc ctgaagtttt gatttttttt 118140 ctttatgcta cctatttcct taaatttttc tcctttccct gcttgtatca tttcgttgta 118200 tcagatttcc ttgcgttggg cttcaccttt ctctagtgcc tccctgatta gcttaataac 118260 taacctcctg aattctttct caggtaaatc agagattttt ttcttggttt ggatccattg 118320 ctagtggact agtattactt ttggggggtg ttaaagagcc ttgctttgtc atattaccag 118380 agtttgtttt ctggttcctt ctcatttgga agctctgtca gagggaaggt ccagtgctga 118440 aggctgttgt tcagattctt ttgtccctta atgtagtact ctccctattt tcctatggat 118500 gtggtttcct gtgagctgag ctgaagtgat tgttatctct cttctgggtc tagccacaca 118560 accagtctac ctggctctga gctggtactg agggttgtct ccacagagtc ctgtgatgtg 118620 aaccatctat gggtctctca gccatggata ccagcacagt atttggggtg tctcctgcat 118680 cctgcaggag cagtccactt ccttctgtgg gtcctctcgg gattcctgtt tcattcttga 118740 agtctagatc tattttttga cagtctaatc ctaacaccat ttactgagga acactctttt 118800 tttcattgtt ctgtaatgcc tcctctgttg taaattaaga tcccataaat gccttggtat 118860 ttgctagact ttctttttct tctgttgttt taaaattttc tctcccaaca agataaaata 118920 ttgtgtaaat attatatgtt tatactaagc atttttatct tgtactgaat aatagtgaga 118980 atgcttcaaa atttcactgt ttttgctatt aagtatgata ttaagtacgc tattaagtac 119040 tgtataggtt tttggctgac ttatttttgt caggttaaga aaactgctct ctatttctag 119100 tttattaaga cagtttatca caagtattag cctataaata atggtttttc tgcacattcg 119160 aataatcatt tgattcccac ttttaaatta ttaatgctgt agattatatt gatagatctg 119220 cctgatatta aactatcctt gcattcttga tctaaatctt acttgaatgg gatgtgttac 119280 tgtattctct ctctctctct ctctctctct ctctctctct ctgtatctct cttcctctct 119340 tcatctctct tctgcaacat cttaaagcat attttggtaa atttgctttt tatagttatt 119400 gattttcaga aatatttctt tgagaagcta aaaatgcaaa ggttttattt caccttgttt 119460 caaatatagt aattatctag gaataagaat tgtccatttt ctacctattg agaatcaaaa 119520 cattcacaga acataaacct acttgtttca aatatggtag ttatctagga ataaggattg 119580 tccattttct acatattgag aaaaaaacat tcaaagaaca taagcctaaa acctctcttt 119640 cttttgtttc taacctacgg gaagcctgtc acttttctaa aagttatgat caggctgagc 119700 ttcactcccc cttcctgggc tctctggtag aatatgccct cccaagtcct ccctagtgtg 119760 agtccgcccc tgtccccacc catcccctct atccaccacc gcccccgctc tcaggctgcc 119820 ctgcagttgt ttcttaatgc agcagaaggc tgcaacaacc acaaactaca ttgcccatga 119880 tcaacccatg cccatgtcct tctgcacccc ccagtcagac tacccactcc cacaacaacc 119940 aatatcagtg ttcccatatt tcatgcatta tctatccttc tctcaaataa agcagatcta 120000 gcacatttta attatccttt gtgacagtct ctagtatttt ccttgttttt ttttttttgt 120060 ctagaattta ctttcatctt ctgattcaca ggaaatttgt tccatattgt ttttttacaa 120120 gcaatatcta gttgaattac ccaccatgtt ttactttttt cctcaccatt agttcattca 120180 cctaataaat tcttattgca tgccttgtgt tttcctgcta ttgtacatgc ctggaaatat 120240 aggagtcaac caaatcgtct ctgagctcat gtagttgaca atctagttag agaacagaga 120300 tgataaacaa gtaaatatat atcaaaaata attgccatgg agaaaaatta agtagtataa 120360 ggattattat ttatctaggt tgtcaggcaa gagcttacag atgggtgaca tttgaatgca 120420 tacttgaaag aagtctggga gaaaagtatc ccaggtagag ggaatagcat atactatttg 120480 ggatcttcaa ggaacatcaa agaggccagt ttgttggagc aggatgagca agaagaacgt 120540 agtggtaaat ggaggcagag atagtgggtg agagtggggt tgggaaaaaa tcagatagga 120600 ctttcagacc actgtaaata cttggtcatt tactctaagt gagataggat accatgacag 120660 tgtcctggaa aaaaaaaagg gacatgttct tattttagtg agaccaattt gggtgttggg 120720 aataaggaga ttcaaaagca aaagcaggta ggccattaag aaactgttat aataatccag 120780 ataaatgttg gtgccttggt taagggagat aaagatggag atggtaagaa gtgatcgcat 120840 tctggatgta atttgaaggc atgtctgaga ggattagttg atggagtgtt acttatgggg 120900 tatcagtgaa agaatagagg aaaggcctga gaatctggaa agatgaaggt gatatttact 120960 gaaatggcct acactcttga atgaatagat taggaagtaa aattgaaagt ctggttatgg 121020 gttttataag tttgagacgc ctataaaaca ttcaaagaaa ttattaaata gtgaactgga 121080 tatatgagcc tgtagttcaa gaaagaggtc tggattaaag ttatgatttg gacaacatca 121140 tcatatatgt ggcattagtg tcatgattcc aaatgagata atccagggaa taactataga 121200 gaaaagagga gaggaggata atttctggtg atatttcaat gctaagtggt tgggaaaatg 121260 aagagaacac agtgaagttg accaggatga agtacttact gaggtggaag aatcaatgga 121320 gaagggtgtt caagatacaa aattaagaca gtgtgtcaga gaagtgggga gtgatccatt 121380 gtggcaagtg ttattcattg gttaaataag atgattaaga atttgccaca atgtggaagt 121440 cattggtgac tagagcaaaa gctattccat tgatgtagtg gagattaaag cctgatttca 121500 ataagtttaa gaaattgggc aaggaggaat taaagaaagg agaataagac aatttcttca 121560 agaagttttg atttagaggg gagcagagaa atgggtcagt aacttcatga gcagtaactg 121620 aaataggaga aattatcctt tttctaaaag gagataattt tagtgcacac ttaaggtgat 121680 tcttatcttc ctgcaaaaat agctccttta ggtatttttc aaaattttat acatgtatat 121740 ttctattcca atcatttttg gggtacaagt gatttttggt tacaaggttg aattgtatgg 121800 tggtagtgaa gtctgagatt ttagttcatc catcacccaa gtaatgtaca ttgcacccaa 121860 tatacacctt tttttatccc tcagccaccc ctaccccctc ctcagtctcc agtgtccatt 121920 atatcactct gtatgccttt gcatacccat agcttacctc ccacttacaa gcaagaactt 121980 catggtattt ggttttccat tcctgagtta cttcttttag aatagtggcc tccagctcca 122040 tccaagttgc tgcaaaagac attatttcct tcttttttat ggctgagtag tattccatgg 122100 tgtgtatata tcacatttta tttatccact cattgtttga tgggcattta agttgtttct 122160 acatctttgc aattgtgagc tgtgctgtga taaacataca tgagcaggta tctttttgat 122220 ataatgactt attttccttt aggtcgattc ccagtagtga gattgctgga ttgaatggta 122280 gatctacttt tagttctttg aggaatttcc atattgtttt ccatggaggt tgtactaatt 122340 gacatcacta ccagcagtgt ataagtaatc ctttttcact acctctacac cagcatttat 122400 tgtttgtttt tgggattttt ttgtttttgt ctttttataa tggccattct ggctaggaaa 122460 aggtggcata tcattatggt tttaatttgc atttccctcc tttaggtatt atttaatgag 122520 agtcttttgg tggtaaagta tcttagtttt catgtgtgct cacacacaca tacacagagt 122580 ctttagtgac aggctagttg ggtatcaaat tctgaattga tgtttttttc tctaatactt 122640 ttaaagttta tttgtgttct ggcatctgtt gttactaaat aaaaatcttc caccagtcca 122700 tttgagttca ttagcaggta atctgcctct tattttaagc acttttaaag atttttctgt 122760 atcttgatgc catatgatag atctaccttt tattatactt tactcagtaa ttactgtggg 122820 cttttaatct gcaaactcaa tcaattattc gattttataa aattatcagt aataaccttt 122880 tctataactg attatttgca gttgaattaa atcctctctt tctggaattc caatcatatg 122940 tgtgttggag cttctcaatc tgccctccaa ggctcgtaac tgctctttta aatttttcag 123000 tactactctc aatttttttt ttaaaaaaac aacctaatat tgcagtgttt ggcacagaag 123060 aagttcaaag tacaactttg cactgccacg ttgaccagct attctggcac tggttattct 123120 ttaaagttat ttttaaggtt aacgtacctt atcaggcagc aggtctcaaa acctagggaa 123180 gcttaaaagc ctaaaggcag cctggcaaaa atcaagctga ttaaaatgct ctttcccatt 123240 ttcttgtcct cctatgccct catccctaaa gaatagtgag agggccttcc ttaaaaagat 123300 atgtataaaa tagcagaaag aaaaagggga tccagcaagc gtgagaagac atacttagat 123360 aattcacagt aaatgttcca aataatattc agcctcacta attctcaaat aaatgtaaaa 123420 caatggcaga tcatttttat ccattaaatt agtgaaaata ggaggaaaag aacattttgc 123480 tgacaattgt taacagtgaa actgaaattc tcttcttgtc tagtttgaat ctaaattagg 123540 acagtttgaa agcaattggg tgatatctat gaaaaatctc ataaacattc tacccttcca 123600 tgtagcaaca ttgcttctgt gaatcaacca ttaggcaaat aaatggaaat aacaaaccaa 123660 atttcccccc acctcccaag agatgtttat tgtaacatta ctgataatat tgaaaaacta 123720 gaagcgatct atatcagtga tccacccttg ttttgactgt cactcaccgt aagaaaatat 123780 taggtataca aagtaaccca acagacacac ccatgcatca aaaagttcca tataaggaaa 123840 ccgttcaatc cattccattt atttaaacaa gccaatgaac aaagctggct ttgatccact 123900 aaattgatcc tacaacctaa gagtaggtta tgactcagtt tgaaaagcac caatctgaat 123960 gtcctataaa agatatatga tggaatatga attaaatttg atattcacaa ttttttactt 124020 ttttttgttt gagggtagtt ggaggggtac tatgtttctt cagccagcaa ggaagataat 124080 gtttctagat aactccatat aatggagatt tactgtaatg ataccagatc tgttctacta 124140 tgcccagcca ttcttatgta tctgtctctc aatgcatcat gggtccttta tggattcttt 124200 tgtgatgtcc tcaagcttcc tgtccactcc ctagcaactt gcccaaactg atagaaccgg 124260 cctgaatcag tcaacatctg atttcaagca ttttctcttg gtcagccttt ggtattagga 124320 ctttattctc aatctaatca attaatatta gctgagctag gttgatttca tttgaatcaa 124380 caaagaattg ctaaaagctg catttcctag aaaatgtggc aatataattg gcaggtactt 124440 gagagtcttt aatgttaaat ggaaaaaaaa taaaaaataa taagagacaa ctttttatac 124500 ggagcatgtt ttcggttttc tttagatatt ttgttagaga caaaaaagga atccagaatt 124560 tattttatac tacattagta cttaacagat ttctacataa gcaagtatta tgcatttgta 124620 atcagaaaaa aatatcaaaa ttagctctgt ggaaaatgat catcttgcaa gcaagcatca 124680 tgtaccccta cttttgattt agctcatctt cttgatgtaa atatgaagtg tctgcgcttg 124740 aaattctgtt tgaagtggaa atcttcatgt ttgtcttaca aataccatct cagagtacat 124800 tgctcagtat aaaacttgtt ttggggggtt gggtacaaaa acctgcaaag atatagtcca 124860 ggctcctttt cccaaagtcc ttcactttcc tactcttagt ataaccatta ttttgtaaaa 124920 tttaataagg cccctaataa cttggggttt gggaatttga tttgaggtaa catgcctcag 124980 agtatcacct attttttatt aaaccaacaa atttctatct gacaaagatg tgcatttatg 125040 tgggccttaa taattccccc aaataaaact attcgtaagt tctaacagtt ccaaatactt 125100 ttggtttcag cacactaata ggatttatag ctgtcttaga taaggagcag tatcttctaa 125160 agctcatgaa aaagccatat cagaatgcca tgtgttcagg tatatttcct tttctttatg 125220 gtatcaagaa taaaatctca gcttatgttt tcactcaagt gttgtgtgat tactttttcc 125280 cattactctt tcgattgagc ctgaaaaatg aggtgaaaaa atctttctct ttcaaggatg 125340 aactagaagg atctaggctg gctggtcacc aaaccactga ctagttggcc ctttgtcttt 125400 ttataacccc tcattgtctg ggatccaaca tcatagtgag tctcagacat gttccacaag 125460 tctagatagc cctcatccat gtgttcagtg gtccagccca tcagcatcca agccagcagg 125520 gtgaggaggg gaagtgtagg ggatgctcat tgccctgaag gatgcatatg ccacttccat 125580 tcaggtcctg cttgccagaa catagtcatg tgaccacagt tagctgcaag gttggctgag 125640 aaatgccttt cactgggttc tattactaac tgaaaatggg aagagtgaaa gttggggata 125700 actagtaaat attagttagt ccaagtcatg gattgtggta ttaattccat gtgctaggaa 125760 ggtcatttaa atgttttatg cagaaggatg ccatgatgat aattatgttt caaagcatat 125820 ttgtgtgtga gagagagaga ctgaaagaga aagtgagata aatggattgg agagaatttg 125880 tctgagtgtt aagaggccat tctcaaaccc aagtgggaaa tggtggctag taacagtagt 125940 gaggataaag ggggatggaa tggactcaaa agatacagaa gagataacat caaaagatga 126000 aacaggggca gaggaggaag aaaagacatc cagataactc ctaggtttct gatttatact 126060 gcaaattctg gggatcaggt gtttatggac cactgagttt agttttagaa acgtgattta 126120 gaggtatttg tcagataggt ggtttctaca cattcaaaat aagatttcaa aacatattag 126180 ccacaattca caatcagcaa aattctcaaa tctagtcatt gtcaactaaa ctattaaaat 126240 gaattttccc ctctaagtgt ttctcatctt aaagggtttg tatgtattac atgtcacagt 126300 atggtttatt gcatataaac atgggaaagc aagccaggca gaaggagtct tgtaaccagc 126360 taaaggccca gctaattctt gaagcagtca taaatcatga acggtcttct tgtgttaata 126420 gtgtggacag gactgttggt cacacacagg aaaatgagtc acacagtctt gtgtgtacag 126480 caactcactc cacactcaat gatgggaatg gtcatgattg ttctaactgt gtgagcagct 126540 acaagaatta tggcaaagct ccagagctag aaagctggtt ttttttttat gtcacccgag 126600 tatgtaattc actaaatgtt tagtatttta taccttttag ttgacttgtg agccctttct 126660 aaaggagatc tatttccctc tactagaagg taatcagaaa aaccctaaac tacgttttct 126720 aaatgctgtg ttcttctgcc caattgacca aaatatactt agttgattag gactttgaag 126780 ggatgagatg aggggactaa attaagatgc aggaatttca gttttctagg ggttttctgt 126840 aaactacttt atactgctga caaatggtta aatgtttcca atgaaactaa gtatgctagg 126900 atttctaatg agcaatgaaa ttttagaatt catttactca ttaatttctt catttacaag 126960 atgtacaatg tgctatcttc tgggcatttg gggtacttta atgaggtagc agtgagtacc 127020 acaaatggtc acttctgcct ttgttcttat actccttaga gaagggaaag gaccagattc 127080 agatacccta tcactgcttt ctacccatcc agatcagagc ctttgctgag ttctaacgct 127140 tagccctctt ctcagctgat ttggctgcct ccattgtaat aggcctcatg agactccagc 127200 ctaggcctgg ccttcagttc agcaggcaga gcccagagat gtactgggca aaggtcaggg 127260 gatttattat atgagacaat ggtctgatgt gatttaattt actcctctgg taccagatat 127320 gtgtgtgtgt gcatgagaga gagagattga gaatgactga tttgggaggg attttgtgaa 127380 ggtttatata tcaaagcaga aagaccaaga atttagagat taatacatgc caagtggtaa 127440 ccaagaaact tctgtgggat cccacctcca acccctccct ctctgtcaga ttttaaccaa 127500 atcagtgtga tgtgatctgc ttgcatatat gagtgaaaga aaaaggaaat ttaaaaagtt 127560 cttgatataa agcctggagg aaacaatacg aaaatccagc ctctatttca gcaatatctg 127620 ccggactatt ggttagtatt cccttactgt tacttattgt ttgattaaaa ggctgatagt 127680 cagggttttt tttttcttac ttttgcattt tttagatata aatctttaat atatggctgt 127740 ggccagatgt tttcctttct cctcccactt cgttcttccc tcttctgggt taatttctca 127800 ttgttctctc ttccccttac ttctctgccc ttttcctttc tactctaagc gaaacttctt 127860 tttttctgtg ctggagttta taaagtattc ttttaggcaa agaaagcctt tggctgcctt 127920 cctccttgtc tggtcaccat caagatataa ttttggtttt caaaggttgt tctctgaagg 127980 aaggactagt tttctgagca tttagagagc agatacattt tgagaaagtc aacagagata 128040 gtaatttgca ctcaggaaat acttaagggt tttaattctg ttccatgtgt tacatttcaa 128100 cagtttacat taagaaaagt attgtaaaga gaagtgatac cacaattgca tgtttatttt 128160 gcatctttag tctgagagat ggtcagtact ttgaaggaaa gagaaatagg gctttgtctc 128220 cttctgcttc ttgctatacc tcttttcaga ttaactctga tgctttgggt ttcttactgc 128280 atgcctgatt aaaacccatc ccataatgcc tgatgtgatg ggaaccacca cttattctat 128340 ctcaatggaa agtattcaca tgagctttca acagaaggac attctcccac ctcttccaaa 128400 cacctctttg aaaaccgtgt ccatgggcct ttattcatgt cttcaacaat ttgtttaaaa 128460 ctggttgtgc taggtagtgg gcaatataaa gatgagccac aggagagaga tgacaatatc 128520 actgattcct tatagtgctg taataagggt ttattaaggc tgtgatagaa gtagagagga 128580 gaggcacctg acttcacttg ggagtggggt tgttgctaag gtgtttctaa gttgaaatgt 128640 ccttgagctg aggtttaggg gaatgagtag caaagatgga ttaagtgaga agagtatagg 128700 aggcagcagg gccagaggtg tgaatagccc agaaccttct gagaagattc ctttgtggac 128760 ggaagaaagg ggaggtttgt ggaaatggtg gaagataagg taggaagagg ccacatcaga 128820 tcacacatgg ctggatgtac ctctctaaaa gtactggggg gtttgaaaca gaggctataa 128880 attggcagtt taagaaaatc actgtggtgt cagtgtgaag aatacatttt tgcaagattc 128940 taacgaggat tattttcaga aatttaggcc caatttagtc cagatgtcag ggctagtttg 129000 gagtaaattt ctttctttaa ttactccagg gctcttgtat tgcttcaaag aaagtagaaa 129060 gtggaactca ccctcattca gggagggtgg gcaagcgacc agccagctgg ggaaggccaa 129120 agagccaggt caccttgtgc ccgcacttgt tatgatttgt ttgtattgtc tgcctgatga 129180 tcaatgatat tagctatgac agcacgtatg agcctggggt aagtgtgtct tcttgctact 129240 tgaagtgctt cttgaaaata gtggcaggct gaagacaaca aggaatactg aaaaagccca 129300 ttggactggg gacaggagac ctggtgctgc tcccagcttg gccggcacca gctccggggg 129360 cttagacaca ttacttcacc tctctgggct taacttaccc catttgtaaa atgcaacctt 129420 tagactaaca ctgttctcgg ggccatgttc agcctctggc ttctgtcatt gtgatcctgc 129480 ctccccaagg ttcccctggg ccccatcact actaacccta ggcttctaga cattctgatt 129540 catagagaaa taggaaagcc catttatctt aagttaatgt cagccagaag tacagttgtg 129600 tcttaaggaa tctaatctag tgaacatgga aaataatttt ctaaggaaaa aaattgtgat 129660 tggtgttctg tcctgaactg atggcaaaag ggaagcagaa ccacttcaca catctcaatc 129720 tctctgtttt ttccttttta tcctcttgaa tttttctgcc tgtttgtctt tcaaaagtag 129780 agaggagttt gaatggggat gctgaggaga ctgagggtag ccaccgatgg gggaagctgg 129840 actgtgggaa gccgagttct gccacctgac aaaggggcac gtgtttagtg tttatttggc 129900 atagcagctg ttcaggtgga gcccaggcag aattttgatg tcgttgggac cttccatacc 129960 tttctgaaat tctcttgcac caacacccgg caccctcagg ttatgttctg ctgcccaaag 130020 cctgaggctc aacttctagc cctctctttt ctcttttacc ggaactaact tctaaaaatc 130080 cagaaatgac aagtagatgg tggtctggat gttcctgagg tggaaagaga acctctagtg 130140 cctctggctg acattatatc cactgacaga tcccctcccg cacgcataca tgtcacatgt 130200 ttctgctcat ttatcaaata cagcccatgc tttggtgatt gagagcagag tggggattat 130260 aagttgatgc agtaggcctg tgtcttgccc ttagaagttt acaaacagca acacaggcac 130320 caagagctca tctgttacac ccacagggat ttatcatctt gtgacttgga tattgtggaa 130380 tgttttatag taaaggttaa aaaaaaacaa tgtaggcaca gaggagttaa cagctaagtt 130440 gcggtgggga gtctggaagg cttcatggac gtggtgatat ttgaacgtga ctttgaaggg 130500 taggtagagt cctgatttgt ctaacagtag ccttgaaagt aaaggaaact tgaccatgaa 130560 gaaggctgtt gaaagtctgg agaaaagaga aggtaggaga ctaagactct aggagaaggt 130620 actacgttcc agggagaatg cagaggtaga atcctccctc atggtgacaa gttaaatgtg 130680 agaagggatg gagtaaccaa ctgggtgaac cctgatctca ttaagcaaaa taagaaatag 130740 aagaaatgaa tctgcatgct cataatgtag ggatcagaag caggtaggaa atgctgactt 130800 tattttagac agaggttatt ttaggtacct gtggacatcc aggtgtatta tttccctatg 130860 tctgaagcac atgtcctttg gttctttagc attttgatga tgatgctcca tgtaaactgc 130920 cccctaggat tttctataag ttttcttcct catttgagag taaagtttta actggtaaca 130980 tgatcacaag tggttgaaaa gttaaaatgt tattcatata gctttccaat gaggggagca 131040 tgaatggttt ggtactgttt tacaagatgt gaaaactgat ttcacttaag tagactgtaa 131100 cataaagttt atgtgtctgt ccctttggct tcctggtagg tggacagtct ctctgaatca 131160 atagtggctc aggcttctga tttcaaacct ctttggccag ccaactggtt taggagaaac 131220 atggccaggt cattgaatta taatttcctg agttatgttg tggtggtccc gtaggacagt 131280 aaacataagc ctcctgggaa ctgaactttt aattcaggag gactgaaaac aagctcttct 131340 gagccaagat ttgcaaggac atgttacaaa gatagactgg ccttcctgct tccacaccat 131400 tttttcctcc ataaatacat gctccttttc cgtatttttc ttctacccta gtctgttgta 131460 gattttgacc ttggctgtta ctttcctacc aacacattgc ctatttttaa gtttcctggt 131520 ttgacctgat gttaagatgg aaagcaaagc tagcaaactg atggagatag ggccttccag 131580 cctttctaac tttccctggg atcatcttat gttgatttac atgttcaaaa aatttttaaa 131640 aataaataaa ttgtatcagt tgatccagaa gtgattagac tctaggggcc tgatttatct 131700 tagccaaact taagagatga gccaatacac caaaatgcca atatatttgt ttgttctcta 131760 tggcactgtc aagcaatttc atttcatctg attactgtgt tcattttcct gaaagatagt 131820 gaacccagaa aacaagaatc agaaggtcat ttgacaactg tggagttgga atagagggaa 131880 ctgaatgacc ctctattggg tcatgaggga gagcatcatc aagctttgag aaattattgc 131940 acctgtctct gtgttgggac atttttttgg tcccaggtag ttggaagaga caaagctgta 132000 aattatttac tagtttttca acatttcctt atcacttatc gttaactgat ggaactaagt 132060 tttctctaaa gtcccttatg aataaaattg ctagacattg caaaaatgcc cctctcaata 132120 ttgacatgct tcagtggtga ttatcttcct gattaatgtt tacagtcaat ctcaagctct 132180 ataatggact cttaaaggct gtagtagttt tctattgctt ccataacata ttaccacaaa 132240 cttagtggct taaacaatac ccatttattg tcccacagtt ccatatgtga gaagtctggg 132300 cacaccatgg cccaactggg ctcttgctta gagtttgcaa ggcagaaatc agtgttgtta 132360 gggcctctag ggatgaattt tcctccaagc tcattccagt tgttttcatg aactgagttc 132420 cttgtcattg ttggaccatg ttccccattt ccttgctggc tgtcagctgg gagccagttt 132480 ttgctcctag aggctatctg cattgcatct catggtttct gtgtgccccc ttccagcaac 132540 aagattctat gtaccccctt ccagcaacaa tattctatgt accctcttcc agcaacagaa 132600 gatcaagtcc ttttcaagtt tctagtctct ctgacttccc cttctgccat atctcattct 132660 gcttttacag gctcaggtga ttacatcggt ttgtgcagat aatccaagat aatctccctg 132720 ttttaaagcc agtgggttag ccatcttaat tacatctgca aaattccttc acagcagtac 132780 ctagattagt gtttgaataa cccaggatgg taatcttgcg ggggatcttt tagcattcca 132840 tctacccagt ctcatcagca acactttgaa atattgtcgt tgagtgatca tttctgtggc 132900 cggctgattt catctataca agtgtattct ttttatttgc cattttatag gataatattt 132960 tctgatctta attccatatt tcagtattaa aattacttga catagatcca taaatcatca 133020 tctgttgcaa aaaagcacat taattgattg gttgaatggg gagattgaga tatttctttt 133080 ctcttcttct gctcaggtgg gggcaacttt tgggggcaga tgagttctgt tgccacaaaa 133140 gttatatagc acatttggtt tgcactgaat cagcgattct caatcctggc catgctttag 133200 aattatacaa gaaaaatctt caagtatcaa tactcagtcc ctatcctact gatccaattc 133260 atctatgata aagccagagc attgattttt aagttctgca agtgattcta atatacagcc 133320 aaggctaaga actactgata tgttccaaac actctatttt ggagataaag aagttgaggc 133380 tgaggatgag aacttagtca cataaagttc cataactagt aacagacaga agttctgtcc 133440 tacaaaaaaa aaaaaatttg atgctttaat tgtatgtaga gttcagtgct cagtaattat 133500 gtacaaagtg agtgttgaga cgatctggaa caccctactt cttgctttag taggaagact 133560 atttctttct actactttaa aaaattatca gatcttgcaa aataactgta tgaaggtctc 133620 ttctcagcag ctttggcctg ccttgtgagt aataataaac acagatctat tctacactaa 133680 ctagggagct ggccgcttgg acttctacta cctctctgtg ttccagagct tcatggtaca 133740 atgcagtagc cactagccac atgtagctat taaacacttg aaatggaact agtttcaact 133800 gagatgtatg tgagtgtaaa aggcatacta gaatcaaaga tccagtatga gaaaaaaggt 133860 gcaaaatatc tcattaatac ttacattgat tacatgatga aataatattt gaatatattg 133920 agttaaataa gatacattat taaaattaat atatcaattt ttaacttttt taatgcagtt 133980 gctagagaat ttacaactat gtatgtggtt ggcatttgtg gctcacatta tatttctgtt 134040 agcacttttc tagggagtat tttctattaa agctattaac aatgaatggt ccaagtccaa 134100 gctattacac ctcctttgat cctgaagagt gaaggggtac actgtaaact tcctggagat 134160 gagacatgat attgatctgc cctgtgtttg ccatctatct ggcagccagt cagtctggcc 134220 aaatagactt ctatttttac atagaagctt aaaggaggca ggataatgcc ccatgtcatg 134280 gagagagcac actgcatagc tcttgagtaa tgtacccaaa agtagaccag gtgctattgg 134340 aggttctaag gcatagcgat aaatattaca tcccttgagc aatgtaatac agcccttgaa 134400 gaaactgcca tgtcagcact tatgaattat cactgtcttt gacaggccct atgcactgaa 134460 aatattatgg tgtctacctc tctttataat tcacatccaa atattactct gtctttttct 134520 tgctccctgt agtttgttct gattcactgc taccctgatt gtgtgtttag tttgcctagt 134580 tcacaattga agaagcatgg gaaagtaaag gcaggccttg gaaagatcaa gcacagttcg 134640 aaaccctacc cagaattatt ctgtctgtgt gagcttggga gatttactta acctctctga 134700 gctcctctaa acttccattt tctcatttgt gaaatgagcc tttctcttgc aaggtctgtc 134760 tgagggttga atgaaataag aaggtacctg gcacacttat tttttgggta gatgttgtag 134820 tgaacatcta ctctgtggca agcctatggc taattgttag gatgtaatcg tgagtgagac 134880 acagctactg cttccagcta agagaagaga aagacaagga gcctggtaac gtcgggacat 134940 gaatagccgt caatgaaagg cagctattat tacactgcac agtgcaggat ttggcttata 135000 acaaaatttt agaagggtgt tcaggtgagg gaattgagac ccatagtgat taaatgacta 135060 cctgagtcac cagctcggac aatgctgggc tgatgtcagg ttacgggatt gctgactcct 135120 cctctagtaa tgcctttcct gggagatcac attgcctcac tcttggtttc ccaacttgtt 135180 taccttcaaa gaataacttt accatgttgg actcgataaa aggaaagagg ggtttcctcc 135240 aatttttgct ccatttgtta ttagggcatg ctagtaacta actgtctttg aaaacctacg 135300 cttctgttaa ctccaaagaa ggcaggaata catgcacttc tttaagatat aaaaagtatt 135360 tagtatacta taaattatta tagtaatcat tgttagatta tatctcacca agataatgaa 135420 tgtttttgtt tgaagacttc actgtatgag aaattgtctc ctatacctta tttatctcct 135480 tttagattag gtaaaacaaa attttcaaat ttgagtctga agaaaattcc aacatcttta 135540 aatttgttta aggaacattt tccatgatct atatgatcta tcatagtaat ttaaaaaatc 135600 agattttaga atgagccacg tgtagaaaga gaaaaaaagt agaaagtcaa taagaggttt 135660 catttttcaa attttgtttt ggaaaaaact acttggtagg gacaatggtg taaagtaaga 135720 tataagaagg aatatactgt tcaaataagc ggccatgcaa ttgattttct ctttcatgta 135780 acaatcacat ctgcattgtg aatccgttag tgcaccaagt gaatcaagct tagtgagttg 135840 acaaacatcc acagggatag ttgcggggag gcattataaa gtgcaatgtg gtcctagtga 135900 aacagaatgc ttcgttcttt gagaaagttc cactctgaat agaataacgg tgcataccaa 135960 tatcggagta tggccaagca tttggctact gacatgcccc ttcttctttc actcctccat 136020 aaaggaagag acagagactc aggttcttgt aactcagttg ccttttttga gttctcccaa 136080 gaaaagttct aacttcaagc caagcgtctt gtcactggga tttctgtatc taatttttag 136140 ttctagaaat ccatgatttc acaaaacaaa ttatccaaac ctaacgacaa ccacatagaa 136200 ctttcttaaa gtagacgagg gaggaattag cccctaaagt atttcctgca caattggaac 136260 tcactataga agatgtacaa ttgcctgtac acccaagcac aaataggctg tattattgcc 136320 ttatcctagg agatatacac tttacattat gatggtcctt ccctttcctg gaccttcata 136380 tgatgtaagt gcttgattta ggaatagggt cttacatatt gtggctggcg aagagcacat 136440 ttgctgattg ctctaccaca tgcctagatg tcctcttcat gatatataaa tgagggtccc 136500 tactctcaat ataccccata ggaacataat aaaacataaa tagtctattt gttactacta 136560 ccaagaagac ttcagtaagt gtaataacta acccttttgg atacatgcag agggaatgcc 136620 aaatgcttta aataaattat ctcatctaat cctgattttt ttattaaaaa gggaaaatct 136680 tatcatatga atattagaga tgagtaaact gaggtttggt agagctggga tttgaaccta 136740 gccctctgtg actccaaagc acattcactt aaccccaagc ccaccctctc tgtaaatgaa 136800 gattaatgat agcatctgtg gtagaagcta atgtctcctg acctgggaaa atatctttca 136860 atgattatta actaaatgtg atcagctgcc agtggatcag atgtcatcaa ataaaatcga 136920 gtgtccaggg tttactcaac agtactgtct cttacatttt ttatcaatgt tagtagattg 136980 cttaatcttt gtacctgtta cctcacatga agcctagata gcatcagtcc cttccccagc 137040 cagtttgtgc tgggttcagc ttctggcttg tgaatccagt cagtgaatta atgttggtag 137100 cttaaaaaca gccctgagag aggtatttac atcacagaaa ttggcaaatg atacaaatca 137160 tgaccctttt tttaaattcc agggagacag gtgttaaaca tttaccagta caccactgtc 137220 tatgattcaa atcgggacat aataattgta tttctgaagg taaacaaatg cacactgagt 137280 acccttggaa aaaagcaacc ttccacagat acaatcacac ctaagtcacc taagtcttta 137340 gtgaattttt tgtccccatc attctgcatt tgggaggacc ttttacaaca taaccataat 137400 gattttatat gtcatttgaa attttaaaaa attactttat ttgttcattt ttgttatgaa 137460 agcaaatatg cccatagtaa gcatttaatg tttttgaatg taagtgcaga catataaacc 137520 ataaaatgta tatacgaatg ctaccagtag aaataaaatg caagccacat atgtaattta 137580 aaattttcaa ctatagtcat gcaccacgta atgacttttc aatgatggac tggtcccata 137640 aaattataaa atcatgtttt tatgacatct tttctatgtt tagatatgtc tagatacata 137700 aatacttaat attgtggtaa aattgcttat actattcaat agagcagtaa cctgctgcac 137760 aggtctgtag cccagagcaa taggctatcc catatagcct aggtgtgtag taggctatac 137820 catctaggtt tgtgtaaata cactctgtgg tgttcacaga accatggaat tgcctaatga 137880 tgcatttttc agaatgtatt cctgtcatta agtgatgcat gactgtaatc acatttaaaa 137940 aataagaaat atttgtttta ataatggatt ttatttaatt cagcagttaa aaatatgatt 138000 tcaacttgta gtcaacgtga acattatcaa gatattttgc atcttttctt cttgtactaa 138060 gctttcaatt ctgtgtatat tttatactta tagcacatat gaatttagat gctaaatttt 138120 aatcataaat acttgatctg catttacatt tcataaaatg taaagcttaa aaagtgggtt 138180 catatatcca atctgttata gacttacata tttaattaaa ttaaatttaa attgtcattg 138240 aattcctcaa ttgcattagc cacattttaa gtgctcaata gccacatgtg acttattgta 138300 acataattgg tcattgcagg tacataccat atatccttat tttataaaat tggaaaccta 138360 ggctggatgt ggtggcttat ggctataatc ccagcacttt gggaggccga gacggaagga 138420 tcaggtgagg ccaggaatta gagaccagcc tgggcaacac accaagacct tgtgtataaa 138480 ataaacaaat aaataaaaat agctaggtgt gttggcacat gcctatggta caagctattt 138540 gggaggctga cgaaggagga tcccttgagc caaagagttg gagactgcag tgagctatga 138600 ttatgccact gcactcccaa cctgggtggc agagtgagac ccatgtctct tcaaaaagta 138660 aaaatacaaa taatataaca aataaataaa taaaattgga ggcctactat atatacaact 138720 cccaaaagtc ttttcccccc tcacacgtta cacatttaaa attcccatcc tgcattccct 138780 gctggatctc caagaggaga gaaatctcag caaaagtagt tatatcaaaa ctgtctgtga 138840 gctttttctt cctcactcat aggaaggaaa taaattcaca taaggcattt tggatctgac 138900 cattttccaa attatcatca ccataaaaag ttggtaacaa catgaactct gaaagcaagc 138960 tgtttcaatg catgcctggt gctaatgaaa accagcagtt ttaaatgccc ttttgggtta 139020 gcttcttcct ttttctgtgc tgtattatta gaaaagcttc accaaggaga tcaactagat 139080 ataatttcac aatatttctt agtaatcaat gttggcattt actcttccca tatattaatt 139140 tattaacatc atgcttctaa ggatgcttta atcacttttt taaaaaaaat acttgataca 139200 aattagaggg tgttagttat tttaggtggt gatttgtttt gtttctgcaa aattacaaac 139260 cagatatgag catattattc cctgtgtggc ttaataaact gttttttctt ttttgagaca 139320 gagtctcgct ctgttgccag gctggagtgc aagggcataa tctcggctca ctgcaacctc 139380 cgcctcctgg gttcaagcga ttctcctgcc tcagtctccc gatcagctgg gactacaggt 139440 gtgcgccacc acacccagct aatttttgta tttttggtag agacggggtt tcaccatgtt 139500 ggccaggatg gtctcaatct cttgaccttg tgatccacct gcctcggcct cccaaaatgc 139560 tgggattaca ggtgtaagcc accacgcctg gccaatacac ttttaatata atttttgata 139620 aaggtgttat ggagacttgt caccaaatag tctagtcttc acattaaatt cacatgatac 139680 tcctcatctc tatttagctc tctctcacct ccagtaatga cctcccttgt ctctcagtct 139740 ttggtctctt accttcagct tcccactagc cgtttctcac atttccaaaa gtcttgtaat 139800 tgccttaaaa caccaagtat ccaaagcagt cctatgacct tctcctcctg ctaaccaact 139860 cagatcccca aatcctgatt tctttcacta gcactatctc tcatccacac atactcagtt 139920 atttgtgata gacatgtctc tatcatctct catatccaat catcaccaaa tcttatcaat 139980 acttctcagt gatattaagt taagaagtca tgaagggcgg ctgtacccta aggaaaaccc 140040 acttttgcac aaatctgagt ttctgatcaa tctgagttca gaatgctgtt ttaatctggt 140100 cctacctcgc caatctaatt ttaggccctt ttattcgtga atttgaacct tgttctctat 140160 tcaccagctt cctcagaata ttgtccaaaa catactcaga attcatactc atatccagaa 140220 catttgctct gagcttttac catacaagtt caccacagtt tctctccctt ttccatatcc 140280 accaaagcct tatctgtcat ttagttttaa ttttaagccc ttcagtttga tagctgattt 140340 ttccctagtc tgaccttcta ttttcgggta tgctccttct tttcacagtt tcatgtgttt 140400 gtactgcctt attcttgaag aaccattatt ttgattgctt ttgcattaat ctccatagtg 140460 ccttgctcag tgttagcagg aactagtagt ttaacaaata cttgctaatt ctaaattaaa 140520 gagcatgaaa catattgttt tctttgcctg gagttggtta tagcatgctg gaaaaagtat 140580 tatatctaac cttcatcttt tctcatgtgt ttatgaactg ttttatagcc aaagaataag 140640 ttagtatatc atgggcctaa ttatgtaatt tggaggcctc ctctgctggg cagtctacag 140700 atttaaaatt catgccagct gcattacgct ggttttgaac ttgctttttc ttgagaaaga 140760 tggggagcag acaaaatgcc tcaggctttg agggtagaaa tggtgtgagt tccattatgc 140820 aagaatagaa ccccattttt taatccctcc tgctgaaaat cttgccatga ggctatagcc 140880 aaagaatgtg taaatatcaa aagaaattta gagagggatt ttccctagga aaatattgca 140940 agcttaaaaa acccagtggg ctaaggtcca atttagtaga ttcctccgaa caatgccatc 141000 ctctacttag attgttacag aacttcttat gacagcattt gagtagactc ctgtacctct 141060 gggttaaaag gtacatgtaa taagtttagg tacctgggca aaaagggctt ggcagagggg 141120 aatagaggga ctttcttatt ctcacatcta gtatatcatt acattgtaat gttagataac 141180 attaaagttc caaacttcat gtgtccgcac tctgacgttt cctagggaca ttttgtctca 141240 gctagaatct aatagagaag gattccctca tctagaagct tccatatggg gctctgtgaa 141300 gatgatgtgg acagtgtaca atccaattga atgtcacgtc tcgtggcctg gctcatgtga 141360 gggcactaga gagagttctc cagaggagtg cagatggggc tacttttgga atcattccca 141420 ctgagccaac atcagtggaa gagaagggga ggagttagat tctaataaag cccttatctt 141480 ctgctgaatc catccacatt tttttatcct cctcctggcc cctgcactta gttagagtcg 141540 ggtccctatg cagtgttcca ggcggcagtg aactgcattc acctcctgtt tgggagcatg 141600 gcaattttaa atactttttt ctgctgtaag agtatgcaaa cagatttctg gttaattttg 141660 tgttgaggat tcttgtttgt tttttgtttt gatagagcac attctatgga catatgttca 141720 gcttgtaaag gaagtgttat agttcctttt tttttttttt tttttttttt ggagatggag 141780 tcttgctctg tcaccaggct ggagtgcagt ggcgcgatct cgactcactt caacctccac 141840 ctccctggtt caagcgattc tcctgcctca gcctcccgag tagctgggat tacaggcatg 141900 cgctgccatg cccagctaat ttttgtattt ttagtagaga cggggtttca ccatgttggc 141960 caggatggtc tcaatctcct gacctcacga tctgcctgcc tcggcccccc aaagtgctgg 142020 gattacaggc atgagccacc acgccccacc tagttcttta tttggaagaa gtgaagttca 142080 tttgcaggca gctgctttca aaagtttggg gattggagga aggtcatctt ctattcaact 142140 gaagcaaatg ccacttgttt gtggcatctg ccaggcatcc ttgagatgtc tgaagaggtg 142200 acttccaaac cagaggatgc agccttccga gaaatgcaaa cctgttcaca ttcttgctca 142260 gatgggaagc agaaaaggct gcgtgggaat tggggattta ctgttatact ctggcattgg 142320 aatagcaggt gctactggaa acttctttac ctgacactaa gtgtcttggg agataacaag 142380 taaaattaac acagcatcca gttcttcagt gctttctcca cttaaaaaga atcaggctgg 142440 gcacggtggc tcatacctgt aatcccagca ctttggaagg ccaaggcggg tgggtcactt 142500 gaggtcagga gtttgagaca agcctggcca acatggtgaa accccgtctc tactaaaaat 142560 acaaaaaaaa ttagccgggc gcggtggcgg gcgcctgtag tcccagctac tcgggaggct 142620 gaggcaggag aatggcgtga acccgggaag cggagcttgc agtgagccga gattgcgcca 142680 ctgcagtccg cagtcccgcc tgggcgacag agcgagactc cgtctcaaaa aaaaaaaaaa 142740 aaaaaaaaaa aatacaaaaa ttagctgggc atggtggtgc acacctatag tcccagctac 142800 ttggaaggct caagcaggag aatcgcttaa acctgggagg cggaagttgc agtgagctga 142860 gatcgtgcca ctgcactcca ggctgggcaa cagagtgaaa caaaaaaaga aaagagacag 142920 aatcaaatgc aaagtaaata tttagttacc aacaggatgg catttttagc ctataacttt 142980 ttttcagcct tttaatatat ttctgctgga ggtttccagc tttgattaca tagcctgttc 143040 acctaggagt aaaggacatt gggagggaga gatgctcagt ggttctcatt tgcaaagtag 143100 acgaggatga tgaaaggcca tcagctcaag gccttccagg ttaggaatta aaaacatgaa 143160 tgttgtaaaa accacaactc atatttattt gaaatctcac aaagtgtgag atttatttga 143220 aatctcacaa agtgtgagat ttatttgaaa tctcacaaag tgtgagattt atttgaaatc 143280 tcacaatgtg tgagatttat ttgaaatctc acaaagtgtg agatttattt gaaatctcac 143340 aaagtgtgag atttatttga aatctcacaa agtgtgagat ttatttgaaa tctcacaaag 143400 tgtgagattt atttgaaatc tcacaatgtg tgagatttat ttgaaatctc acaatgtgtg 143460 agatttattt gaaatctcac aaagtgtgtt catctgcatg tttctcacgt gaaatctcac 143520 aaagtgtgtt catctgcatg tttacactca atcctatgaa cgactccatg aagtagtgta 143580 tgaaggagag ttcctcatgc atgtggattt gcacatgggg attcagatac aagaagacaa 143640 tttagtttac atagagatgt gcttttttaa agaaattttt aagaatacaa aattatatgg 143700 aacaaaaaag ataggtcctc tgctgtctag aaattaaagt acgtcaagaa ttttatccct 143760 atgtagaatt acacagccat tgccgggggc cacatctgta ggcccatgga aaaaaacatc 143820 tttgctcatt atttcagcct gattagggat accatgaagg gctattccat taggtcaggt 143880 ttgcacagta ataaaaatga agccagtaga ggatctcgtg gagctcctgg tatgatgata 143940 agtctctgag taacttgtaa atagtgcaat tttatggaaa tgttgcagct aagctttaaa 144000 gtagttggca ttagttgtca gacacagcaa cagctctaca aaaggcaata cgctgagttc 144060 attttcaacc agcccaaact tgcctcagaa gatccgggat gtggacaccc tggtatattt 144120 tttctagaaa agcttatttc cttcctccag ataaaggtgt atggtcactg aggtgttgtg 144180 ctgacagaag tgttgatcta ctctctccgt tagactgaag ggctccaggt gtggccacac 144240 tgggcttcta aatggctagc aaagccacag acgcatccct cttggtgtct gaggtgttca 144300 cattcctggg tctttcagat ctgtattcct catgaaaata aaacctctct acgacacact 144360 gtgtccttgt gggtttttag ttttactagg gagtttttgt ttccttttgc ttccctcctt 144420 ctttctgctt cccttctagt taaacctctt taggatggct cattagcaac tcgttttgag 144480 tggtttgagc tcttttgttc actgggaaac agatttatga aatgttacta ttaccatgat 144540 tgttatgttt ttccttttat ggcctgtcca gctcaaggcc ccatgctttc tgatactgct 144600 gataaggttt tctatttcca gatcaaatta aagcaaacct tactggccct gttactgaag 144660 ctgtgcatgg gggtcgtttg ctgtgaggtg tttctatggc tttgagccag ggtatgaaca 144720 tctctagtgt tcatgttatt tcctgagact agcactcacg ggaagtagaa tttattacaa 144780 cctgctgttt gagttcatga aaagtaggac aatatgagac tctggggcag tgaaagactt 144840 accaggattc cttctggaac tgactcgtca gctcattcat gtcttaccca gtctttaaac 144900 agtatttcat gataatggtc tgcttttaat tgctgggctt taccttaccc tttttgtgat 144960 tgcaggtcct acaggtatgg atctctggca gctgctgttg accttggcac tggcaggatc 145020 aagtgatgct ttttctggaa gtgagggtga gttctgcttt tccatttcca ccctcagtgt 145080 tttgaaacaa cactgaactg tattcgctac atccaagttt tttggatgat tttattaaaa 145140 gatgcaagtt ttacatagca gcaaaaagga aacttgactt agctttaaaa tcagaaacta 145200 gtaggacttt tctgtggatg tttaggagga atgcagtagt cagtcaactt tggcatctga 145260 tgttttcata tcaaaaatta atactacaaa tcatgctgag gacatttatg ttgaagacaa 145320 gccaggtctc ttgttctcag gctttgggag agatattgaa attacactga agggttatta 145380 gcttactgtt cactcagctc atctgtgact aaggatatct aatctatttc cagagctcag 145440 aattcaggct tgttaatcat attctcagag aaaagaaatt gcaggtttca aatgaatttc 145500 acttctcact ctctgggtga ttaccatttg gctaagttga ggaaagagac acctgaaata 145560 gttgaatgat atacccagaa attatgagct tccttcccca tctctataat tctccctccc 145620 ttttttatat ccctctcctt gtagagaagt ctcaatatgt ttaaactatg tttcatagca 145680 gacctaacta aaacaaggaa gagtaataga agggaaaggg aagaggaact tttctgtcag 145740 aaagaaaact gtgctctcta acgggtggga gacttttttt tttttaatga gtacttgatg 145800 tttttccttg cctgggcttc tacagaagaa agaaagaata tatttctccc atgctatgac 145860 actgaattta gttgttgctt taagagtgtc agactcccct tctcaccatt cagctcatgt 145920 tggaaaacac agtttaacag cagacttagc gccttaagat gtcctccctg accttctagc 145980 caaaaataaa tccgtagtag tgagctgctg agggtgacca cagtcactta gaaaatgaga 146040 agagtaaaat atgttatttt atctcttaaa gcaatttaaa aatatttata gaaaagagtc 146100 ataattgttg gaaatatttt ttggtctctc tggcgttata atgtcaacat tatgcaagtc 146160 aaacatggag agaattgcag gctccatttc agcagctttt cccatggctg gttttagacc 146220 ttggttctga gccaaagaat tgcagctgag atcctctgct gttccaaagt catggtggct 146280 taatctctcg tttcttcatt aaggtgactt tcactccact gggcaagatt tgaggaattt 146340 aaaaaacttg tgaaatgaaa agtatggcat aggaaatctt taaagaaaat taaaaatgca 146400 tccccagctg agagattaga gctcaaatta cattttagaa ctagaaagtc tgcaaggagc 146460 atctgtttca gctgcttcga cattttacta aaactttgag ttcctgagtg aagagaaaac 146520 atcactagtt gcttttaatg tttgcttttt gtttttcttt ttaatagttt tgtttgattc 146580 atttatttgt tcagggagag cagaatataa gcaaatgcaa tagtttatac taaacacaaa 146640 tcacatatcc taccagtact tacgcataag aagtaattta acaaagaaga acatttttgt 146700 ctcttttttt tttgtcttat tgaactaacc aatatttctt tttcctttgg aatatgtgca 146760 tattccagaa tcctttctta aaatggtcta aggattaagg atggggcatg atgtttatgt 146820 aagaaggcat atgtaagcac gttccagtgt gtgtgtgcat gcttggctct gtgtgtgtgt 146880 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgttcta gttctggcca cttatctaat 146940 gaatgggttc atgggttcag ccaaagttac tgcataacat gacatgggtc agtctcagat 147000 aatatttatg gaccatgtgt ttgtttttct gccaggtctg gattgtagcc aaatcatttt 147060 atttttattg tgtctcctat tgaataaggc agactaaaaa tatagattaa atttttaaaa 147120 agaaaagata ctactattga attcagtttg ttcagtgaaa gatgtggcat tgatgggtaa 147180 gtgatcttgg aagcatcacc tggagaaaag tcacccagga gctggtagaa gatgacagac 147240 ctgtatgcgt agggaagggt agcacttgag cagggatttt cttgcttggg cagatgagca 147300 attagaaata tactggccct gaaaggattt ttttttatta aatctaattg ccctgtggga 147360 aatttaatga gaactaaatt tgaacagtgc cgttattgtg ttagctaaag tgttgtaata 147420 gatgttttct gtctctcatc cttaatatga agttctcatc cttaatatga agctctatat 147480 ctgctcctca aagccagtta catagtctag aggagaattt tttattccaa aatcaggaat 147540 gatccacaat gccttgtttt caaagggctt cacatggttg acctatcaac tgattgtatc 147600 aaaattgctg ctgctggaat aatgttgcta atgagaaatg tgcataaaga tctaatggat 147660 ataagtattc ttccaaggag tgcctgttat aaattaggtc gtatatctct actatttcaa 147720 tcagtctacc cttgaatata ccctttgacc tcagtaacct aaggtggaag taagcaagcc 147780 cctgccttgt agttcagtct agctgggaca tgaggaatgt cttgaaatta atgagagcct 147840 gtataccttt aaagtctaga ttgtgtgatg aagagaaatg gtcaagatgc cctgaaaaag 147900 aatagatcaa ggtggactag aatagttaat tcaacaaatt cagtgtactg ataattctta 147960 agagcttcct attttcaaag cctgcaccta tggctatgag gaatacattg attcttccct 148020 caaggaactt ttcatgggtt aataaatcag gcatgtacac caagaattac aatatcaggc 148080 attgtatatt aactatcaaa atggcttgaa tcacacttta tagaagtgat gatgacgtga 148140 gggatacctc agctgtggtg aattacagct tcatgaagga ggttgacatt gtttctctag 148200 agactagaat gtcaggttta agattttaaa aggctgagaa gaacagaagg ctattacagg 148260 aataacttat gtgataaagc aacaacataa acagaagtgt acagatgtag atatgagatg 148320 tctatggaca acaattcatt cacttactgt gctagtcaat ggatggttct attttatgca 148380 tttaacattc aacaagcatt tcttgagcac ttacttcgtg gaaggcatag gattaatttg 148440 gccagggtgt gtggtacata ggtgctatat ttgtaattat tccctttgga agcaaactta 148500 ggtcagtagg tttgagtcaa attatagaag gcccagagat agcaaaggca ttatggaaaa 148560 ggcaagactt gctgggccct tgaaaaatcg gtagcatttg gagaggaaga aaagaaagag 148620 gaagtgtatg ccatatccag ccagtaatag tcctcaatat tggaggccag acaaaagcgc 148680 tacctgcatg atggaatagt gtgtgtgtgt gcatatgtgt gatattcata tgtaacatat 148740 atagtatcta catgtaatat tgatatataa tatttacata caacatattt atatttgtat 148800 gtgtgtaata catacactat atgtacacat atacatatac atgtatatat atgtacacta 148860 tatgtatata gtatatgtat gtgcacacca gtgaggtgtg gcttgcaggc aaagcacata 148920 attgacatca ctcaaattct gcaaaaggtg ttatatcatt ctgtaccatt caaagtaaga 148980 gacttaggaa tgagatgcca catcctaagg gaaccaagag ccccaaaata attttttctg 149040 tatattttga acatttttca taaacctatg cacactgaca aaacacttac ttgaaaggaa 149100 agacacccct gttctcattg ctatcagaca gcaacaattt attttttaaa ataaactcta 149160 ttccaccaca gttgaggttc cacagagctc tgagaggatg tcaagacatg tcagatatat 149220 ttcacacaag tattagagtc atggtttcag ttagtaaaca gtaatgaatg catctgttaa 149280 atgtgttcaa gaatgaacac ttcaaggctt tccattcaca gtgaaggtgg ggaaaaaagc 149340 cacagagctt ttgattgctg ctgtcttcac cataatccag aggcaagaag aaatcttatg 149400 gtgtgttcta gtgcaatggc ctgcgtccat gtacatcagc aatcctctgt ccccttgtcc 149460 tcctgatatt gcagaattta tttgatgttg gagttcagca ggtcacagca agctggatta 149520 atctagatgg tgccaatgta gataatgaca cataaaaagt ctttcaagaa gcttttatta 149580 agtcatttta cagattcaag gaggaatttc atgtatttat ttatttattc attcaatttt 149640 gcatgcatgc atttattcat ttttttgttt tagagatagg aacttgctat gttgtgcagg 149700 ccccaaacag ttctactagc ttcaaacaat ccttcttcag cctgcagagt agttggcatt 149760 ataggtatga gccactgtgc ccagcccaag gaagaatttt gaatgtatat tcctgctttt 149820 aaggagctca cagtctttag aagagaaaac agagaaataa acataattta attgtgatcc 149880 tcttagatta ttaaagggtt ttaatctagg taataatact gttagatttt tactttgtca 149940 gtaatactag taataggata aaagtgaatt tgaaagggat gaattagagg aggaagttga 150000 tgacaatagg tcaggagaga gataatctaa gtgtgacagg gatgataaaa aatagatgga 150060 tcacaaacac ggggatgtta agaagacaga attaccagta ctcagagtct aattaacctg 150120 tggatttttg actcggggaa ctatcagtgc cttcttttcc atccatttct aagtttctgc 150180 atttttaatt aatgtgatca tcagcaatga ctcacgttta atgcagtgaa gtcctggtgc 150240 acagttcagc ctattagcac taaagtggca cttgcacaga acaactctgt aggggaggaa 150300 acatgctgag gctggatgac agcagagtgt ctaagctacg cttcttttgt actatttctc 150360 tgaactcctc atgcctgtgt ctaccctggg tcctgcagct gtctgctcag ctctgcagta 150420 tggctgtggt atggctcagg ctactatgca gtgagggtct acagcaagga caaaggtctg 150480 aactccctcc tcattgtagt ctctggacat gtgtgactct atcccaaaac cttgacaatc 150540 ccccagatat tttgtcattg ctagagtatg tacttactca tgggatacaa taaaatatat 150600 gcaggatgag ttgagaacag cagagccatg tgctgggcag agtctgggag gttggttagg 150660 ctcccacgga aaatgagtga cctaccccta caaagaagct ggcagtgtga gtgattagat 150720 ttgtgccaca gctaattagt aaattgaagg agtgggacca cccaagaata ctcagaaccc 150780 tgaatgttag ttaaattcac acatgccagt gatagagtat atttctggtc ttccgcctta 150840 gatgccagct cttacgggaa cagagccagt cctggttata taatagaatg tttccacacc 150900 actttggttc agtatcctaa attgtggctc ttgttatggg gtagacagga atgaggttga 150960 cataacgtat ttggtgtttg gtgatggcaa agagtacctg ttcatagaca cacctggttg 151020 tccacctctg gctagagacc aacccaagtt caactgtgca gaagtccatg ttggccttta 151080 ctggcccagc cagcctctac ctgagatcat tccctacaac aaggggccca ggattcctca 151140 gtcaccccag cagcttttcc caaggaaaac catctcatga agaatttgcc attgatgatt 151200 ttctcctcac tgtgcatcga agtcaatggg tttattactg agagttggtt ccttttaaac 151260 cttaacctta cactgtatat gatatagaac tgtaggcagg ccagggtcat caataaagac 151320 atttttgggg cctctacttg gcttgtaacc acctgcttat ccacagtact gtgcacctag 151380 cttgtcatca ggcagagtca ccagcagcca caacaaaagg gtgcaccttc gtcttttcca 151440 agcagcaggc aatgtggctc cattttaact tttctggcaa tactcacatg gattgttaaa 151500 taatgctgtc aacagtgtca tcttcaaacc caaagcaaac ttcctcatca tctgtagtta 151560 gcagcatgaa gacggtgatg atgtgtaaca taaacacact ttgaaatctg atgcaattga 151620 ccctacgaag agagtattcc ttagtgccct gtctggcaac ttctggacag accaggaggc 151680 cttggggctt agagcacttc ttcagcctca gctgcaaatc cattttttct tgtcccttgt 151740 tcccaggatg aagccacagt gtttcatcag gtacatttat caggaatctc tgtttctgtt 151800 tatataacaa tttaacttaa gcctcaacct tcacagtgta cgcatcacat ttccatggaa 151860 ggattgcagg tattagaaga tggtggatca tgtcttaacc acaggggaaa tgtttcagga 151920 tgtttttata gaaactttca ctaacaagca ggacacagga ttggcagaga ggtgggggta 151980 ggaggcaggt gaagggtggc atttgttgtg tttccctctt ctaaatgaag ttataatgac 152040 atctgtgttt caagagtgtg gcaagtttgg actgagcttg aaataaatac agtttaattg 152100 gtttcaaata actgaacaaa atgaccattc catgccctgt gtaataaaat gttatagaat 152160 taaaacttat tagacgttaa aatccatgaa ggatattttg ctggatgccc atccttcagc 152220 attctgatga ggatcttcgt gtatttgttc aatgaataag tgaatcagca gctaaatcct 152280 gacctttgat ttcctcagtt ctctcctgca attgtcactg atgctctcat ctccagtcct 152340 gagcaaggca ggagttgaat tagtatcccc ttatagtggg aggggtctag aaatagctgt 152400 gccactttag aagctaggct ttgtgggctt ttccggggga tggaatgatt tcattttcct 152460 gctttctact ccacatacca ccaagatcag aattctgccc taaacactaa tgtgtgggag 152520 cctgatgtcc tgcctaagtc ttgtcaacct ctttccaggt gactgaactc cgaaccccat 152580 gcaccagtca ctggccaaca ttctgcatta agtgacccgg tcacccagca ccatccccct 152640 gacaccacct ttatctctac accacctgcc tcctgcctga ttaaatctcc tcaaatattg 152700 acagacataa tgatacctga agatcccaaa tccaaatttt ctttgcccct ttggacattg 152760 aactttagat tacaaaagac cctgactagg gatcctgtgg atagctgagt caattttctt 152820 agccccattc cttaaatatc aagtctttct aattttccaa tgagagcaca tgaaactctc 152880 aaggttaaaa gtcaatttat attaataaaa tctttaattt cttgatttct gaatatgaaa 152940 aaatgatact ttgtgtattt tttaattttt tggcaaaacc ttccaaattt gtggaaagag 153000 aaataatatt gactactgga taaccatgtg ctatgtgtaa atattaacgg attcacctta 153060 gtgggcactg acttgatgat gtttgccaca ttatattttc cagagccttg gctctcccaa 153120 aaaatgagag gtcatttttc aggggaggac cattttgtgt ttggctaaca tttaggacat 153180 ataatttctt ctcctctaca tgccactgac ccactgcatc cctggttgga gcaagaagag 153240 ccatgctttc cttaataata gctaatggtg aaaggatgtg ttgtaacaag agcagaggaa 153300 tagggaaaca ggagaaagac agtcagttga agagtcctgc cctgtgtcag ggcaccgttt 153360 ggccagctgg gcttgctagg agtagaatat agaaagtaca tgaagtgcca tactcagaca 153420 gctctggcta cgttgacaaa ctggtatatc atggtgccca actttctttg ttagctgggc 153480 cagcatcata ccctctagta tttgctctga acttcgtaag cacggttgac tagctttctt 153540 ttcctctgca gttatcattc agactgaata gtttctaaga ggctcttaat gagaaataga 153600 aggaagtaag ttaacttctg tgcatacctt ggccatattt gcttgacaaa ctgatgtgta 153660 tactaaagcc attatgggtg tgaaaggcaa aagtataagt gctccccagt atgacctggc 153720 tattttgtct tacttctata tttgattgct aaaaatatat gttcttgggt caaaaaactc 153780 actttaaggg aaaaaaatgg aagaatatta ataaccaaaa tagaagaata ttaagaactt 153840 taacatgaga tgtatttaga tcaaaaccat ctctttttgg atttttgcgg gtgatttctc 153900 caacatgttt agaactgggt tgctattcac ccaaaggtgg aaacttttga tgttggggaa 153960 taccactgat gccttaaagc agagggtaaa aggaaaagac tgaaattcca ggctaaaatg 154020 aggagagcat ggccaccact gagcccaagg tagcattcaa taaatactat ataaattact 154080 gatttatttc tacagttggt tgatagaagc ttactatgat ctgcctaagg gtgcatcaaa 154140 ttcctctggt acttatccta ttcttgacta tcacttcctt gggggcagca gttaatcagg 154200 tagaggctta tcctgtcaag agagtaaagg gagctatgga ggaactcgct gggaggagaa 154260 gctggtcctc agagatgctt agggtttagg accagtaaga ggcagtctcc acaccaccca 154320 catctgattc ttgtctcctt cttctctgct gtggtcagga gaaacagttt agattaggga 154380 tttcagagca gtggtgttga actttgtcaa aactgcattt gaatcccatt tatgaattgt 154440 gtgatttttt taaggttgag ttccccagaa gtaggatgct gagacaagga ttcctatgaa 154500 agtgaattat tagaaaatgg tccagggaga aagcgatagg agagtcagaa aatgagacgg 154560 ggaaggtaaa gaaaccagac aaggatacaa tatcaagtag aatccaacag tggtgtgggt 154620 gggtagaagt atctgtctca gcagattttg agttgtccag attatcctca gttggtggtt 154680 aaggttaaat ttgcatcctc acgaggatgc aaatttctac acactatcag ttgtccaagt 154740 gcaggtaaag ctggctccag cagcctgagg gcagccgaca gagagacacg ggtcctgggt 154800 gtgggagtga aaccacacat gaagcctgca tgtaaaaaaa aaaaaggtaa agaggggctg 154860 ggcgcgatgg ctcatgcctg taatcccagc actttgggag gccaaggcgg gtggatcgag 154920 aggtcaagag tttgagacca gcctggccaa catggtgaaa ccctatctct actaagaata 154980 caaaaattag ctgggcaggg tggcgggcac ctgtagtccc agctgctcgg gaggctgagg 155040 caggggaatt gcttgaaccc aggaggcaga agttgcagtg agctgaggtg gtgccactgc 155100 actccagcct ggtcaacaga gcaacactct gtctcagaaa attaaaataa taaaataaaa 155160 taaaataaaa taaaataaaa taaaataaaa taaaataaaa taaataaaat aaaataaaat 155220 aaaataaaat aaaataaaat aaaatagtaa agtaaaataa aataaaggca aagagatcaa 155280 tctacatcac caaagcactg acagcatctg ctacagtgac tttggtagtt tcttacattc 155340 tctgagcctc agttttctta tctcttaagt cagaggaaaa tgacttgttt aaaaaggctt 155400 caatgaggta acacaagtaa agcatgtatt gagattacta cacaggaaaa gcagttgctg 155460 aatacaatta gtcaactggt aattggtaat aattatgtaa aattcctata attataggga 155520 gcgctataca attattatat ataattccta taattggaat taccaatagg ctaattgtat 155580 tcagtaacta ctcttattgt cctcaagttg agttattatt gcaagccctg agggctgaat 155640 aaacatgcaa actaaactga catgtagaat tttatttata acaatatatg cctaaaagaa 155700 gcggtttatt tgcacaagga aattttggaa gctacagata attttaataa tgactacaga 155760 aaactatctt gaagatgttt ctaatgttta agacataata gcataagcct ttataaaatg 155820 ggatactgtt atgtagttat agttgtaaga atcagtgttt aaaggatggg tttgatgaaa 155880 ttgtactact ctagttcctg tgcttctaat aaaattaaat ctgattaata cagcaagtag 155940 gtctttggtg agttgattct gatgctggga gtgattttct taattcttgc tcagaaagcc 156000 atccatgaga attaaatgag atagcatgta caatacctgg tatagttact ggtaagaggt 156060 tttcagtaga gaccaatctc ctctttgttt accttctcat caagagagga agaacaagga 156120 aaattaggtt gcttttttga gaaaatactt taggccaatt acaattatct gaaagtagaa 156180 tgaatttcta ggttaggcaa gactagagtt aaaacgtggg tgtgcagggc tgacctgcca 156240 gggtactctg tatggaagta catggaaatg tatgcccaaa tacagcttca tataattgtt 156300 ttgatcatac acagtttcca catgagatta tatttgaatg actaattcag caaatataaa 156360 aaaggagaaa accagtggac aagatgattc ctaaggttcc tttcttcctg gtctatgccc 156420 tagtgtatta tgaattgata ttcactggaa cacacagtta ctgctggaga ttgagttata 156480 aaaacattca aatgggttac tccattatat ctacttagga aatttttttt taaaataact 156540 gatagatgtt cagttatgcg aaacgaaagg tatttctggc taccccttta tagttgtgta 156600 catgactgca gagccatcat ttcatgctta cttccccaca ttcatgtacc attttctcaa 156660 aggaaaatta ttgaatgaac ttgctagttt tgattctggg gtttgtttta aacaactgat 156720 atttaaatcc acctagtcct ctttagctgt tctcctagga actttaatat taacaaacag 156780 ctgaacttat acattttgta aaagagttca gacaatgaat tcattcttct tgaaatgcat 156840 ggaagtaccc aggtgctagc tacacccaag agccttttct aaatacaaaa aggattgaca 156900 aaccaagcat tcatcctgtc tgcgtccaac agttcggaat caaaccatga acttgctgtt 156960 cctctgtttg tggttagctt gtttgtatat ttttaaggaa gatgattcaa tgcaagaagt 157020 agttttatat agtacgttaa gtaaatttcc tatacgatat acttaatcag aaaaatattt 157080 ttgaactaga gctcacagaa catatgatta caatagtttt cagaaagcaa ggggctaaat 157140 gaggatttct caaccttggc actattgaga ttttaggtta atttatctat ggtgggaggc 157200 gtgtcctgtg cattgtagca tatttatcag cagttgtgac ctcgtaccca ctagatacca 157260 gtagtccccc ttctcagttg caacaaccaa aacaactata gacattgcta agtgttctct 157320 aggggtcaaa atggctcctg cttgagaacc acagtctaga tctggtagtt gcatattgaa 157380 ctgacagtcc ccaggattgt tgtggggatc aaattagata aaacttgttt atatttttta 157440 aaaagtaaaa ctaatacata tagttacatt acacctcttc ttttcatttg ttactcatct 157500 aagatttttt gagccagatg atggagaccc ataaataaat taaccttaag aggctcaaag 157560 gtttgccagg taaacaaaga gttagaagaa aaagagagat catgtcagat gtgccttaat 157620 gaatgtgtgt gtaacatgta caaaaagtta tgggaacccc aagaaagaaa agactccttt 157680 tgaatgaaat cagagaaaac caactggacc atacagttga agctctataa caggaattac 157740 caattaacta attgtaacta aatactcttt tatacaatgt catatattca tgtagttttt 157800 aaatctagaa gtagttaagg ttcataattg tcatttctca gggacactac tgaagtggta 157860 tcaaatctaa atgagcaact taagaattga agttgtcaga cagctgttaa ttcccctttt 157920 tcatacctgc tccaatgata gccaacaatc aaacaaaaat aataaaataa aaacgaaagc 157980 aaaaaataca actcagattt cactacgtac agcaataaat atcagagaca ttagggaata 158040 ataataggtc aaagcagaaa ttcattcctc agcatgttct tcaagtggaa gaattaggtc 158100 tgttttagtt ctgttgattc taaaagaaac attcaggcta tcaagaaaac ctgttttaaa 158160 ctctaaatct gacactatag atagatagat agatagatag atagatagat agatagatag 158220 atagatagat agatagatag atgatagata gatatagata gatagataga tagatagata 158280 gatagataga tagatagata gacagataga tagatataat tctgcctaag taattatctg 158340 ctggtaccaa agagattgac aaagagattc actaacctac cagaatttcc caaccttgtt 158400 ccagggtatt ctacattaaa tactcattac caaggaaatt ccacataaaa gctgtcatgc 158460 ttgatggagc catatttaca tgaaacgttg cagcattttc ttctttaaac ctcttctaca 158520 atttgaccaa ttccatgttc cagggagtac tcagaggctg attaggacat gagttgttag 158580 catgtgctgc actaatggtt atgagtcaca tttgttttgg aagatcaccc ttaaagcctg 158640 tcactcatgc ttgtttatgg gaaatacaac aacttaaaca tcagttaaca aatccccatg 158700 aatgcatggt catatttgag tgcttctaac aaatgcttcc tttcatttct cccttgacag 158760 ccctaagaat taaaggctgg tagagcaaac tgggagacat ccatgaacat ttattaaagg 158820 aagcatagga gagtatgata actgcaaagc cagctgttta tattattggt gtgagattaa 158880 atttcatcag tcttaaaacc tgctttttac cactagagaa atcaatctgc catatttaag 158940 gttacattaa cgtggaacat tccacgtact gaactgtcac atgcctttaa aataaccatg 159000 ccatgctgtt tttttttttt aaaatcatta cacatgaaac aaacagctga caggtgggga 159060 tctattggta tattcaagtt tttcatgtga aaatttcccc caatattagt ggtaatcaca 159120 atttgattat gagaaacaaa cataccatat ataggcagaa ctatatatca gtagccttta 159180 tatttgacag ctcactgtaa aatccatact atgattcagt gaacatattt atgtcttata 159240 tctgggttga tctggttgcc ttcagctttc ctcacttgaa aaaactatac ttaaaaaact 159300 gtaatttaat gttaaagtta attaacacag caaatactta ttgatgacct attatttact 159360 gggtactatt ttcggtgctt gcaatgcctc aatgaacaaa agagataaaa acctctatgg 159420 tcatgctgct tgctttagtg agatatatgt gtgtttgtgg ggtggaggac atgaatgtga 159480 ggcagacaat aggctacaaa aataataaat tatctagtat tttataaggt ggaaagagct 159540 atggaaaact gccccatttg ttcctcatct gagtataccc aaaagttgat ctttaatatt 159600 ttatatgagt ctcctaggtt ctaaatgtta gaaactaatt aaaaataaat tgaaactaaa 159660 ctaaatatct ttgtgatctc tctggctaga agcctcagga ccagtcctca ctgtttactg 159720 atgaggaagc cgaggcccag agaattaaac gatgtagcca agatttcaag cagttactgt 159780 cagaggtagg accaagacac acaacctcct tctctagtgt gtttttctca atcggttggc 159840 atttaacagc aagtgtttta gttgaaaaaa tttatttgaa aatctgtttg aaacatgaca 159900 aaataggaaa tacctgctta ttccctcact gcagagtggt cctcagcaga aagaagattt 159960 tgaagtttat gaattatgtt cagacaagac ccttataaaa tcactctcct ctctccagtg 160020 gcagaagcgt ggcccctgac tcctcaccca ccttcattca tctttcgtat tccttgaaaa 160080 ttaccactga gtattttcct tctgcttcct gcagcaccag cagaaaagat gaggatgcgt 160140 ctcttgattg ccattacaaa tctctttctt atgcttgttt ccattcttat tctgcacata 160200 acttggactt ggccatcatt cttagagctc ctctaaattg tttgattaaa agattgttta 160260 taagtccaga gtcagaacgg aattgaaaag gcactgcaca ttatgatgga gaggaataaa 160320 ctccagtcaa aagtcatggc ttctggactc accaccctaa ggcagcctca ctggaacttg 160380 cttttccaac tgtcagtgga gttttagaat tttcctactt gcaagcttgt tgtgaggatt 160440 aaacggttaa gagagattgt gtctgttatg gaattgtgaa aactgtaagt tgcagtccac 160500 actgtagaaa tcttagttac ctctgccctt tctttctcta gagacaggtt gctagtggaa 160560 tagacaagtt tgccattaat ttgaaggttg cattaagcat atattatgtt agtgaagttg 160620 gtcttctgaa agttggaagg gacctcagag gtcctgtatt agaccaactg tggctgttcc 160680 ttagaataag ctggaagttt tctgaaaaat acaaattctg aagcctcata catagagatt 160740 ctgatgtgga agatctggaa ttgatggcag cagcggccca tctggagccg ctgctgtgaa 160800 gatgccggct gtagtggggg aggtgcggct gtggttgtgc cctccacaga gctgccaggt 160860 gggaagcctg acccttctga gttggcaggt ctgaagccca gtgctcttca ggcacagttg 160920 cagctgccca tctgtgcctc tagacctggg catccccgtg ctctcggggg cccaggaagc 160980 accccctgct cctgcaggct tggaagtgcc tgctatcact ccctggcctc tccctgcacc 161040 tgcacccagc acccgctccg gggtgaagca aagtcatggc caagcctgga tgctgtcatg 161100 acctggtcag gtgtgcacac actcggagca gtgctgacac accagccccc tggcacatag 161160 gcactctctg gactttggac accaaccagc atgggaggga gactgagagg gcactaaggg 161220 gtggttcagc gcaggcctgc aggcgcccct tggcatgaac agcctgggtg ctgtggatga 161280 catgtagatg gtggcagaag gcagacaggc tcctgggcag aaagaggcca gtccccagtg 161340 aagctccacc ttcaagccag ggatggccgg aagccttgtg gctgagctat cagttccagg 161400 tggagtcctt ggctgggagt gagaacttat ggtgctttat ccaggccttc ccatagccac 161460 ccatggacca ataagcacac ccttcctccc ttctgatctc ataaaatccc tggacttatc 161520 caaactcggg cagatgtcgg gatgacctgc ctatggataa gagctaccca cttcaggtct 161580 cctgagaact gtactgtcac tcagtaaagt atttcttcac cttgctcacc ttccagttgt 161640 ctgtgtatct cattcttcct ggatgtggga caagaactca ggacccactt aatagcagga 161700 ctgaaagagc tgtaacacga acagggctga gacatgcctt ccctgcccac cacattgtag 161760 gtgacaagaa cagaagagct acagcccttt ggggagccca gacctgtgtg acaccctctt 161820 tgggggctct gcggtttctg tcatctccat gctcccaggc gtcaccacat tcccctcgtc 161880 cagatgcagt tgcccacggt ggaagccatt tgcgtacatc agatgcagcc gcaggcttgc 161940 atggagctgg tgcctgtgct ggtgcctgga gctgctcacc ccaccacggc agctggtgta 162000 cctggctgta cacagtggct gaaccccatg cttacccact cacgtatccc tcattgctcc 162060 acgcctggct tgcccttggc aggcatgggg tccaggctgg tagcgcaacc cgagcatagc 162120 ctaccaggcc gttggcagaa caagcccatt gggcccgagc aaaacttggg caaatgtgcc 162180 accagccaca aaaaggaaac acaaaagttt ccagctggaa aagcaagacc tgaagaatcc 162240 tgcaacagaa tgatgctctg gagtgttttc tgtgttaggt gtgcttgttt gtttgactaa 162300 acctccaaac atgagtctga agattaacca gtttgggaag ccttgcttca gctttctact 162360 gacattaaac tccttctcct ctcccatttc tgtcttcact tagaaatgga aacccactaa 162420 ttactcaaga tcttaccttt tccattcagt caactaggcc cttgcacccc cattactttg 162480 cgttccacct tgacaattgc tattgccaaa catcggcatt aatctatttt gacatcttct 162540 ttccacctgc tgccctctag tggaagtgct gacaagcagc aaaatattta actgggaaca 162600 gcaggaaagt gaccagtttg agctggccag ttcacacaag tcagcgcagg tccccagcat 162660 gatgtctaca gactacagct atgccagaaa tcgttaggat ggcctccagc tgtttggaca 162720 ctatttgcac acaagttaca tttagagcag aactttgtaa agaccctggc atttattcaa 162780 gggcttttta aaggtttcaa aaatctacct ggaaaacatt acccttggga tatttttgtt 162840 tctttgtccc tcattttctt cttttgtcat ttacccaaat tcttcttctt gcaaaagaag 162900 gtggttcttt cctgccttcc ctaacctttg aattttccaa atcttgcaaa aaataaagat 162960 atatatatct ttaaataaag atatatatat atatatataa attcttacag tttagaagct 163020 tccagtcacc aggtgaaagg aattcacatg aactgaaaat tgacaatgta aaggacactg 163080 tgttctccta ctgttcctcc aagtctcttt gcggtccgtt agtagtcttc ttttttccag 163140 gagacactga agttaagaga gtttaagaag attgtagtat gtcacaaagc aagtggaaaa 163200 gctagcacta gaactcaggt ctggctgatg gaaaaccctt atgtattttt tttaatgtgc 163260 ttctttggtg tttagtgatt atttagtctt ccgtgaagta ataaataata acttgcatgg 163320 taaatgttat taaggctcga ggtactaaat ttatagcaaa agtcattcag ctttttttta 163380 aatgaatgtt taataatcag tgtgtctctg cataatctcc aattactcct tttagcagag 163440 gaacatggca ggaatgcagg taagtttggg tgggaggaaa agacagcaaa agccacagca 163500 ctgatgcaaa gttgagacta gatttcacag ggcagatgcc gtatactccc tcaagctttg 163560 aagaaactaa atagttatct atgttaacca atagggcaga actcgtactc caaacaccga 163620 cataaaccgt gtgtgtgttt tgtgtatgtg tgtgtcttcc cccacagcat tctgcacaat 163680 tattaaccct ttttgtgtag tggtttttca taattttatc cttgattgtt aatatcatgg 163740 taagtgatgt gttataaata tatttttcct taagtatcat aaacaatcta agatttcatt 163800 tggctgattt ttcttttctt agtattgcat atcattattg ctgttagaac actcatacag 163860 attattcagc ttcttaacta gaatgtatac acacacacac acacacacac acacacacgt 163920 gcatgtacag aactgccttc tttctctttg atggtagaaa atacagctct ctatagtaag 163980 caaatttgct ttcagtctca gacataccct tcattctctg catgactggt aaagagcgga 164040 aagagtaata cttaggatct ggattccagt tccctgttct ctgaccattt aaaaattttg 164100 ttaccttggc caggtaaata cagttctatg aacgtcagtt gtgcctcaat tgagcaggct 164160 tgtccaaagg attcctcaag gatgaggtat cctttcagct gtatgagctg aaccttgatt 164220 tgtgcaatag tttaagcccc tgaatagtca gataaaaatc atgttaatta aaattaaata 164280 gctattggta ggatctggtt ttccactggc ttgcatgaat gatgttttgc cctcctttct 164340 gatactcagc tcagaggatt ccttccattg ggttttcttt cttgtagttt ttctggttca 164400 taaatagcct atagacaaac actaaactgt tacaggtaaa aggaccctag attaagcctt 164460 ttataaaaca aatagtcctg tgtaaataat gacatcttat tttatgtgtg tgaatttgag 164520 ttttaggatg tagggcatgt ctgactagat agctaaaggc tgagctccag gcagccagct 164580 gctatccaat ctccacacct ggaatgttcc aaaaaacctc ctgtgttttc tttctgcagc 164640 taagcactga tgagcaggat ttaagaagta cagccacaca ctttttgctg cacgtttttt 164700 aaagtttgtt atttttgtca tagattactt gttttgaatc aaaaattttt aaagaaaact 164760 taatctccca aattttaacc cccttgaagt ttcaggattc caaggaatat ttttatttta 164820 agatgcataa aatactcagt acatgtacaa aggtaatgct tataagaaac ttagaaaaaa 164880 aaaaggagct agtaagattg agaaggggaa gaatatctaa gctaacatta ctaacctggc 164940 aactattata ggtggctgga tagcatgaag gcataaagct gaaggcagtt aagaaaatag 165000 actggatttg aatcctggct ctacctggat tagttttgtg acctcagaga agttgcttcc 165060 cttctctgtg cctcagtttc ttcatatgta aaaggagata actatagtgt ctaacacaca 165120 gaattattgt gaggattaaa taagttaata catataaaga aagtccaaaa ctatggcaca 165180 caaatgttta atatatgtaa gctattattg ttataaaact aaagaaagag aacccagaag 165240 acattcagtt tggtgggatt cagatatatg ttttcctttc ctcctcctcc tcctcctctc 165300 cttctctaac cccactatgc ttgcctccca atctatccct gactcctatt tttcttcctc 165360 ccaacttaag aattgtcact aaaaatattt agaagaaaag aaaatgtgca tacttcaggg 165420 ggtgccaagc ttttgggtaa agtacacttt tcagctaaca tgactgtatc caacagtaat 165480 gggctttatg gcaagaaaaa gcttttttct caataaatgg gttttaactt tgtaatggat 165540 tattctcttt gcatgggtaa ttcttctgga agatggaaat tggctcgatg ataagatagg 165600 acagttggat ttagggatct agattaaggg actatcatgt atgcttttag gagagaagtt 165660 taatctgcaa aacctacttg tcttatttaa ttaattgttg ctcttagctg ctcaattttg 165720 tacaggtgac ttgcatgaaa gcaaaatgta tgtcaaaatc caaaagcaga gtgaagcctc 165780 gggacttcag tgcttttggg tgtctttcca gacctctgct cttcccccac cctcaccaag 165840 gccccactga cctcaaaggg cccttcttgc caggccgtga attacgtctg agccagaggg 165900 ctgggactac agccaaagcc aaatgaaggt gcagaattta ggactaaaaa aagcctgagc 165960 acgtggcact gggtatagca gataaatttg ttggagaaat ggtttataaa taacatgaaa 166020 agggaaaggg gatagagggt caaaatattg agctgttgag agttgttcaa tatttgaggt 166080 cagtctcacc atttttaata ctgaacccaa aagtaataca cactgaaaaa aaaaaaaaac 166140 tcactgaata aaattaacta cagctgggct tattttttct tatcaagaca tttgtaagtt 166200 tggcagcaag catttttaaa caggatctct attatatgaa ataaatttaa aaacatgtgt 166260 ctacagtcag gacaaacaag tgaacaaaaa caaagcaaaa gcaataaaga agccccatga 166320 aggcattatg cttttctgag gacagtataa ggctaggata ctgcagaaac tgaaatactt 166380 agggatctta ttgaaatagt tttcttttcc tccaaacaaa gcaaccatct cagagggata 166440 gatgggctaa aagacaagga ataaagtaaa cagaagattg gtaacttggg aggttttctt 166500 ttcccctttc tctttttggt tttgatttgc ttttcccttg ttaaagccag aaaggataaa 166560 ttttggtcca gaactcccaa gaccagaggg tcagggaaag ccaccccgag gctggaagct 166620 atgaacttat cgctagtcta aactccacct ccttcttccc tgggagtcct gcacaaatat 166680 aactgcctga tctttctgtt tactggcaaa ggttttgctc ccttctcttt cgtatcggaa 166740 tgtgaacttg gggaaagatt tggggttttt tttgtttttt ttttgttttt ttaagaaaca 166800 gagacttgac ttattcctcc cacaaactct taccctggca cagggagacc acaaactaag 166860 tgaaaacaag gtaagaagct tagagaaatg ggaccatatg ccctccccgg agctgaaccg 166920 tgttccctgt ccaccatcac cttgtcttcc catgctacta ctccactcct gtctcttcca 166980 cactctgggt cacatgtcta ccccttactg tgagttataa tcgcccagga agggtaaccc 167040 attgactgag ggccaagctt ctgataagtg aatgaacttg tcttttctcc tggccagata 167100 tctgtctttg ccagagaggg ctgagtcagg gagactaaga ttttcaaggt caaattgtat 167160 attgtttaaa attgtgaaaa tttgctttgt gcattgaatc tcattttcaa aataaaatta 167220 tgccttaagt cagatcatac tgatgcagat tctgcagatg ttaagaggct tccatgattg 167280 tatttgccag ctgcaggtca ggcagtggtg gatggtggta agaagtaacc tatacttttg 167340 gctgggagct gtggttcatg cctgtaatcc cagcgcttta ggaggctcag gcgggcagat 167400 cacgagatca ggagattgag accatcctgg ctaacacagt gaaaccccgt ctctactaaa 167460 aatacaaaaa aattagccag gcttggtggc acacgcctgt agtcccagct acttgggaga 167520 ctgaagcagg agaatcgctt gaacctggga ggcagaggtt gctgtgagcg agatcgcgcc 167580 attgcactcc acactccagc ctgggcagca aaagcgaaac tccatctcaa aaaaaaaaaa 167640 aaaaaaaaaa aaagtgacct atagttttgc agtagaattt tgaattcaaa ctcaggcttt 167700 atattttctc caaagtaaat tgtattttgt tcattttaat ccattggttg actctaatga 167760 gatctttctg actggaaatt ctgccctttt tttcctccat aactgtatta ccagttatct 167820 ctcatccatg tgtttgataa atccatatga atgtcttttt ttgttttcta ccaaaacctt 167880 tataacaaaa caaaattcat agctttgtca actacacttg aaaattatgc cccaggcttt 167940 tcaggattct gtaattaact tattgagtca tttgtttaac cattggtgaa ttcatttatc 168000 tttactcggg ccacagtaat gtattttact tacaacatat tatgagaaac tacatcacct 168060 gcttcaccga aattgaaaaa cattagatga acaacactgc cctaaaccat atttcaataa 168120 tcctttcatg aaaggaaagg aagtacattt cctataatga tttgttctta gtgaagccat 168180 gttgactcca agtgacctgt tgtttccttt ctgggctcat agaaataatc taaccattct 168240 aaaatattga tggggattca ggtcaaaggt atagttttaa aaattcacca tatttaacct 168300 gttaaacatt cagtatctcc taccttctgt cttccaaaaa tccaaagaaa taaccattta 168360 ttgttccgtt tatgctttca gtgtctagga catagctaat ctgatactga acatttgaac 168420 ttatcgttag ctttgaaaat atgccctatt gtcctattgg ctttatacta aagttttatt 168480 aatacattcc ctcaatagtc tccagtcttt gcccaagaag aagaaaattc tgtaagagtt 168540 tctttttacc ttcctttctt ctctgagtgg aataatcttt tttgttgtct tcatagtatt 168600 ttagagtttt gtgagatcag acaaaattta cctcagctta taactttatc ttttaagtgg 168660 aaaaactctg aactattgat tattgtgtca tcttgaaaaa atagtctatg gaatatatat 168720 aagtagttgt gttatttttt tcagtgttaa gttgaccttt ttcttttagt gcattgtgaa 168780 tatttaaaag gtcatttgtg caacatataa gaggattgac aggtttccat gcatgatgct 168840 taatgtggag atgatttctt tccatcaagt tattatgctt ggaataagta acacatctta 168900 aaattacaac cttgatgtag caaatcatca gatgggttac cattacatgg aaagagccag 168960 tgaaataaag accattaagt tcaggtagac agagatggcg gtgagaaatt cacagccaaa 169020 gagggccata tggaggtgaa aacactggta aatggctctg ggaccctagg agtctacagt 169080 aagtcattgg gaagttggag tggagaaagg caacattagc taggtatttc attcattcct 169140 ccataaatgc ttattgggag catgttgtgt gcctggcatc atcctagctt cactgaaaag 169200 aatgaggaac atataaaatg tgaaggtgag aataagtgag aagtaattgc tctttactct 169260 caattatagc tgggcaagta catatatgaa tatgcttttg tgttctgaac acacactaag 169320 cagttggtca aagtattaag ctagagacaa cttctacttt caaatgtagt gtttcaaaat 169380 aataataata ataaagattt caggacagtt tacatataac catttagaga tttaaggatt 169440 aaaatcagga gggaaggaga aatgtctctg ctggggaaat ttttttaaac tagtgttttc 169500 tactcagcta ctcaatgtga tttcttttat tttcttcctt ccattgctta ttggcattta 169560 ttgtggggaa gactgctgtg ttggcagcat gagagagatg ggaatcaaga aaatggaaac 169620 accattcaat attcaaaagc cactatcccc ttaaaagcaa ccacagatca ttcagttttg 169680 ccacatactc agattgcaca ctaactggag gatgttaaaa agtgttctat tacaaccagt 169740 tatccagttt ttgccactta aactctgctg tgagaaatgt gactgtagag cagccttaaa 169800 aagagatcat cttgatatta agcagtgtta ctcatacatg cttgttgaca ttctaacagg 169860 tgactttgaa tggatcttca ggctcagaaa catggttgtg tccctagaac tggtgaggct 169920 ggaacaaggt gtacagaagt gaaatgacca cttgctttct ctattggatt tctttatcca 169980 gctgtgcaat tgtttcaggg actacagttg attttcctga tgcaagccta gcaacttgtt 170040 tttcagttca gcacagtaaa atatgaacag gagagaactc cctgttggcc acccacctca 170100 caatctttaa aagggaactc tgtacagaag cattctgcat taggcaaatg tacacttctg 170160 caatcaaaat gaaaaacact tgagctgaat cgtttttcgt tagctttagt ttccagccct 170220 gattaaaaag aacacaggga accctgcaag tttaagcggt tttggcagcc gaggaaacag 170280 ctgtgacatt gtcaagggtt gtctgtagga gctgtgcagg ctgctgacag cactgataat 170340 gcccagaaat ggggcagacg cttttcgcat ttggtcatca aaggagtggc agcagctagg 170400 ttcaagaagt gaacttttga ccctgtctga gacaactggc tctcgtggat cttgttctgt 170460 cattctccag tctgattttc tctttcagaa caagtgggta ggatctttgg tttttaaact 170520 gtttgactgt tattaaaagt aagctagttc ttatagctgc gattggaagg gatggaaggt 170580 gaggaagaag agctggtatt tcccactatc ctgcaggggt ggggaaatct atcaacgact 170640 gttccactaa tctgcggatg agttatctag ggaatatcat gcagttgcca aagttttcag 170700 catctaaaag cctccaaagt tctctctgtg agggtctacc tcccctgtct ccagatcctt 170760 cccatgcccc tcagactcag cacttgtcca ctgtccttgc taccagggaa tccctctgca 170820 gcccccttac cctcctgccc ctcccaaaag agctccagac tttgaccttt ctcttccacc 170880 tcaacatctg tttgtgtctt aaactgatgt ccattgaaag aaacagataa actaattaat 170940 gctgagatat gacttatgaa gtattatgaa tgtgctaact ctctcagggg tatgtgcatt 171000 ttaatagagg accagcagtc caaaggccgg tctcactcca ctgtgcccct ctaacagcac 171060 cgagtctatt tccaggcagc cagagaccag gcctgagaac ttgccccaga ccaccagcgt 171120 ccccactgag aaagcaagca gactcaacag tttttcagtg tttcagggag cctgcagcag 171180 caatacagtt ccttcaaagg gtctgtggat tctctcagct ttcctagtag gttgctgtgg 171240 tagtttttgg agcaaaagtt cacgatgtga atcttcacat gctgctcttt gtgccgagca 171300 ggtgcttgca agctagttct gcccctatct gccatcttaa tcctaacatc tcccatgttt 171360 ttttaattta acttctattt tggtttcaga ggtacatgtg caggtctgtt atatagataa 171420 attggatgcc atgggagttt ggggcataca tgatttcatc acccaggtaa taaacatggt 171480 ttccaatagg ttagttttta tgtcctcacc cgcctcccat cctccacccc caagtgggtg 171540 ccagtgtcta ttattccctt atttgtgttt atgtgtactc agtgtttagc tcccacttat 171600 aaatgagaac acgcagtgtt tagttttctg ttcctgtatt agtttgctca ggataatggc 171660 ttccagcact atccatgtgg ctgcacagga catgagctca ttttttatgg ctgcatagta 171720 ttccatggtg tatatgtatc acattttctt tatccagtct actgtcaatg ggcatttagg 171780 tttatcctgt gtctttgtta ttgtgaatag agcctcagtg aacatacgtg tgtgtgtgtc 171840 tttatggtag agcagtttat attccttgga ttgttgggta aaatagcagt tctattttaa 171900 gttatttgag aaatcttcat cctgctttcc atagtggctg aactaattta cattcctaca 171960 agcaatataa atattccttt ttctctgcaa ccttgccagc atctgttatt tttttgagtt 172020 tttaataata gccattctga ctggtgtgag atggtattca ttgtggtttt gatttgcatt 172080 tctctagtga atagtgatcg tgagtatttt ttcatatgct tattttccat gtgtatgact 172140 tcttttgaaa agtatctgtt cagggacatc attcctatga aaatgctagt taattataca 172200 agtattactt gtttccaata atcgattttt taaaaaacct tataatcaat attgcattaa 172260 aattttcagc tgtgtgattc cttatcattt tcttggatgc aaatgccttg tgtcacgtac 172320 tatatctcat aaatctatat tgcatctaac aaagtgcttt gtgtaaagta ggcaattaat 172380 aaatgcttgt ttaatgagta gatttgtttt tgttttattt tgctttctat gttttcctaa 172440 ggatgtgggg cattaggcca atggaaactg tctctcaaaa gttcttatat ataaatattg 172500 atgtcaaagt cactattttt gtacaaataa acacatttac ctaatttggt gagcatttat 172560 agagtcctgc ctatattcaa ggtccctgtg ctgatcagtg ggcaactgaa gaagtatgag 172620 gcactgttac tgctgtcttc cttccctaat tgggtcctat accttatctt ggtacagcta 172680 cctcctaagg aggcccatct gtgctgttga gggtacatct gaaggcagtg cactggaatg 172740 tatagcctag gactggaatt tggagtgagg ccctgagaga tcatacacat ttttcacttg 172800 tgggggaatg tccttaagta gaaatagatg gtgatttcag atatttgatc caaacctaac 172860 ttcctcattt gaattgagta tgctaataac tattcttgag gctctggaat agtgatgaca 172920 tttcctggtt gggaaatcag atgctgattt ctgaagcaga gttttaaagt tgaaagatga 172980 aaagggaaca aaacaataaa cacaacctta gactgaaggg tcatttttct agtccaactt 173040 ccctccacct agctgccacc caagattgtc cctcagccat ccttagaata ttaaaataaa 173100 tccattgcag tgctcaaatg acttgtttct atttgaaaat ccttgccatt ggagaatttt 173160 tctatatatc ttaccttaat ggctctccac gaattttgtc aacagtttgt cagcaatgta 173220 ctcatgaaaa tatctcatat ctatgtatat tctatcactt tagcctcctt gacttctaga 173280 ccagcagttc ccaaactttt caaatgtgac cccttttagt atcaacttct gtttataaaa 173340 gtacaaaagc cctcacatct tatactttct tttatgcttt tatttattga gatattagac 173400 aacacatact tgtaggtgac atggattctt agatctaaat aactccactc tccatggtca 173460 ctgtcacttc aacacaggtt gatgcagtcc ttagtttgga aaacagtttt ggcataaata 173520 atcccaaacc ttcctatcac ttcttggagc ttttttcttc atgctttcct tgcatctttc 173580 ttaaaatgtg aagactacat tggatatatt attaaaataa tgtcattatt agtgctatgt 173640 ttaaagctga ccttttcttc ctagccactg atatagcagt gccaactgtg gactctcttt 173700 agaatgaaca ctttagtaat aataagtcct tagaacacaa acactgtcac ttgtaaaaca 173760 cttttctata cttggtaacc tacacagaac agcggttccc agactttttc ttttttttgt 173820 cttgtgggtc ctttatatat tcttacaaat tattaaagac tccaaagagc ttttgtttat 173880 gtgaggtttt gttattgata cttactgtct tagtaattaa aactaagaaa attgtaaaac 173940 aacacatccc attagctgtc agagcatcat catgtcttgt aggctctgga aaactccact 174000 gtacactcat gaagaatgag tgtgaaagag ccaaatagta gcttaatatt attataataa 174060 tagtttaact ttgtgagctc accaatataa tacatattca tgacacagtc cctaacatct 174120 aaaaacttac aatctaaggc ccaacataaa tactaataga tgatgctaaa ttctggcttc 174180 acagtgcttc ctacaataat actaaaaata tatgaattta gacagaggcc aaaatgtgtt 174240 tattaaccac ttggctttgc ttagtatttt gttacccacc ttggagaatt gcctctgctg 174300 atttacactt tataagaagc agccctatga aattttttat cataagttta acaatgatgt 174360 agaacatact gtttcatttt ataatgatcc ttgggcaaaa tgtataatat ctgtgggaga 174420 aatgctcaat gctgcagtaa aaactatact tctcctcaga atcaggtatg ttcttatatg 174480 gtcagtataa atcttataac tgtgctttct gatctccttt ggccaccagg aagacaggag 174540 ctgacaatcc aacttactat aaattcttca gggtctgatg tcattatttc tataagattt 174600 tccctggcat tatcttattt ctcaggtctc acttttcctt tgttctgatt tatttttctt 174660 aatatgtttt attgtgtatt tgttaatatg ttttgttgtg tatttaattg ccaatgggga 174720 tgaatgaata agtgagaaag aaagatactt gatccatttg agtgggactg cttgagtacc 174780 tggagtggtg cagaccaagc agggtaactg tatcaggttt cattaatgaa atgggtctta 174840 agtggagatt aggaaggaaa ggaagtgggt tgctggagag gcggggtgtt ttatgtgaca 174900 gattggctgt aataaagatg cagctgtgga gtgagtgagt gatgtcctga gcacagtaag 174960 gagatctggc tgacgtggca ctgcacctca ttgccttaat atcttttcat ttgattgaag 175020 aggcagctga gggataggtg ctcttggaaa gtggagtaac catttccaat taaggaagga 175080 ctctcacttc agtttctaaa ataaattaga agggagaaaa tatgaagtct gagagatcaa 175140 ttaggagaaa gttctggtgc tacatataga aataggctta tccgcatatg caggtgagag 175200 tacgaagaag aatctgtgaa tggcagtcat tttttgtagc tggttccaat taaaattgat 175260 tctctataat gactacttat tggctgctgc tcaccaggtc tgcctttttc atcattgtct 175320 gcagaacata tcacagtata cagcatagag taggtgcttc ataatgtgtt aaatggatga 175380 aatgggttcc tacctccaaa ggagatggaa aaaaaaaaac aggcaagtaa ataaagtaaa 175440 atatgtataa attgctttaa gaatgtttta taaaaaagga cagtagccca acagcattca 175500 cagtaggctg gctggagtag cagtcattga agaaacccat gaaaacagcg gcagaagcaa 175560 atgtgcagct gctctgcctt ttcacactgt agggcagcac acgaatagtc ctggagcacc 175620 agggccctta gactgtggga tttttaagtt acctagttgg cacagcattg actcctcctc 175680 tggtgtgatt aggggccagg atacaataaa catatgttat gttggaactt tgatgccagc 175740 ctaaacttgc cagttcagtg tttgtggttg caggtagtat cagctcctct cctgatatga 175800 ttgagagact gaggtccaag gcttcaggtt gaacagaatt gatggcccta aggattgggt 175860 tagaactctt ccaaagcact tagcaggaag ccagtttact tttcttggat gccagcttcc 175920 aagaaaagat cagtcttgag caaaatagtc cttcactctc agctcagaag cctaattgag 175980 agggtatcct ataagtaaca cagcccactc tgctagtaac ctgttctact tcaacctgta 176040 aggcccatga ggctagccag tgacatcact acaggacaca gtggaggatg tttaggaatg 176100 gctgggtgat gaccagggtg cagattgtgt ttactcaagg ctgattgaga aatactgttt 176160 tcagtggtgt gcttataaat gtttaacagt ggtgggtgga aggggggctc tggcttgtag 176220 catttttcta gtgcccatgg tgtaaatact cccaacatga ccaactttaa gttaccaatg 176280 tgattgaaag tagagtttgg aagcgaggca cagtagccca ctgttatgta gtatttttgc 176340 catacagatg cataagagac ataagtaacc tgaagaacat agataattat taaatgtagt 176400 aaaatgatca tgaagtgaca gatcttgagt gttttatcac atttgttttt aatataattt 176460 aattttaagt tgccataatt taatttgtaa ttaagactat gttaataatt ggcttatgga 176520 atttctgaga attcaaaaac cagtgcccat aggtggatcc agtacaccac taggtaagaa 176580 cagcctagaa gtacttctag gctcttgttc tgaaaggtgc caagactggc atccatggtt 176640 ccagtgccag ggtcgaggaa agacttacta ggtcctgcag tattgctccc aaatctcttt 176700 cagtggccag ggaaattatc agcctgaagg caggctgaat ggcttgctta cattcaggtc 176760 ccagtatcta cgattgacaa tcggcttcat ttgtaagtac cagatagtgc aactccatgt 176820 atccaggagg ctgggaggta ctgagagcag actgatagtg tcaagagaca ctgaaatgac 176880 tgccagctct ctcctgccat atccactact aagtgagaaa ttcagtgaca tagtcactga 176940 ggactccacc actgctgggt gttggggagg gcacactgag tatttcaaga caatccgggt 177000 aagatttttc ttggagggat tcaagtacaa aatagttaat atgcagaaat gaagcagaaa 177060 ttattatacc tcagaaatga gtcagataat actaaagaaa ggaagaaagg aaagcatgac 177120 ttgattcatg tctttaatga tgaccaaaga agttgggtct ttaaagatga caagagaaga 177180 ctgatcaggt agcagtgagg tggaagggga aagatgagag aggggacatt cctggtagag 177240 gaagcaaggt agacaaagtg taggaatgtg aaagagcata atgtatgtaa gtattgttca 177300 ggtgacttct tgggtaccta gatagtagag agaaattaga ggtaagaatg gaggaagggg 177360 agactcaggg ccaggttgtt gagggcattt tatgccatgc taaggagttt ccaatttttc 177420 ctttcagtaa tagcaagaaa cttaaaatga gcaggggttt gtgtttttga aagaactggg 177480 aaaacacctc tgggcaatcc attacctggg gataatgggt gaaatttccc aagttagtgc 177540 acaggctgct gggtagggct tgaggctttc ctcttgcctc ctatttcaac actgtggtct 177600 tttaggactt gtcctcaaca tgttcttaaa aggaatgttt gctaactgcc aaaacagtag 177660 tcttcatatt tattctgttc ctttccaaaa ggtaaattga aaaagcaaca taccctcagc 177720 caagagaatt aatcttttat cacctaagtt actgcccact gcctttcagt tttaaagtta 177780 atttagtgtg cataaatggc tatgagcccc tggaactctc tttatgtttg catcttaaat 177840 ttaccagacc ctccttctgc ctctagttcc agaattttct ttgtcttatt ttcttcaaga 177900 aatgtatttc tttaaattgg attgcaaatt tggaatacac acagtcaaag ccttttaaaa 177960 ccattctttt aaaaaaggac aagtttcttg agaacatttt taaaggaaaa agttaaaata 178020 gatgtcaatg gaagatgcaa atatgaatat aaaatatgaa aagcatctat aggctggagc 178080 ttctcagtag agctctactt catttaaagt catattatct ggcaccattt caaagctttt 178140 ggttacttga ttttgtagtt agaaaaaaag tataaagttg aaatattggg ctctttacat 178200 gaccattttg ctagtagcag tggatgaagc ttttctctaa gagatcaata gctttagtgt 178260 aaacttggtc aataccttat tggaagaggt gactatgtca gattaggtag aaactttaaa 178320 agccagcaag tttccaaatg tccttctgga attggcctcc tagggccatg tggaccagag 178380 agatcttatc acagaagtca taaactgata tccgtgagcc aaatctagct catgggcatg 178440 ttgtttggcc tacagcacat tttttttttt tttttttttt tttgagacag agttcactct 178500 gtcacccagg ccggagtgca gtggcacaat ctcagctcac tcaacctctg cctcccgggt 178560 tcaagcaatt ccctggctca gcctcctgag tagctgggat tacaggtgcc caccaccaca 178620 cctggctaat ttttgtattt ttagtagaga tggggtttca ccatcttggc caggctggtc 178680 ttgaactcct gacctcgtga tccacccccc cgcctcttgg cctcccaaag tgctgggatt 178740 acaggcgtga gccaccacgc ctggcccaca ccacatttgt aagcagatga attggttatt 178800 tttaaaaatt tgaagaattt aacaacaaaa acaacaacaa caacaacaaa cttttgtgtc 178860 cagcttcttt ttttttattg tcccaatagt taaggacaat cctgggcctg cattctttga 178920 acagttggct agacttaagt agctgctgcc ccttttagat ggggcaaaca ttctctactt 178980 tttcacagtc cccttcaagg gtgcttcagc catttttgct actcacttgt cttcaataaa 179040 ccaaggtcat gtttaaaaga ttaaataaca gttattgcat gctcaccaaa ccgtcacaag 179100 gaaccagact tgtgtaccag aacagagtcc tggagcatat ctctgttagg ctagacatca 179160 ctcttttagt tatgggatca tggaaaggtg cagaaagttc cagggaaggg gtcgggaggg 179220 atttggtgag tgaggcactt ggaggcatgg gtcaatagct tttcaccagc tagcatggaa 179280 gtacttttag tgtttaaaaa cctatggcac agtgggatct tctaggaaag tagaccctgg 179340 agatggagat tcacatgtag cacatttatt aggggatgcc actaggatca atatctgtaa 179400 aagagagaga aaggatgtaa gagtgggcag agggagaagt tgagctgcaa agcaggccca 179460 gtgccagcct caactggctc cataaggagc tctggctctg gaatgccctt ttatatttgt 179520 ttcccatggg accaggatgg ctaggccatt ctactctgac atgcatcact cactgaaagt 179580 gggaagagtc ttgctcttga gtgaggaaat cccctgctac tgaggcaatc cctcaaagga 179640 gtaagaagtg aaagctcctg gcctggagca cctgcaacat ctgaaacaag aaatccttca 179700 ttgaacagga tctgggcagc acaccagagt gatcacagtc agcagctata ccagtgacaa 179760 cagatgaata tcaactctgc ctttagcccc tagggtatga cacctggcct accaaggctg 179820 tgcctaaact ctttggactg attcagaatc aagcaagtcc tagcctaaag agaggagttt 179880 aatgtcatgc tacgctctag cccaatattt gctgacttgt aattcagtca ttaaaaaaat 179940 tctttttatc ttcacatagt tttagattgt caaactgtta ccgttctgtg tccagaaatt 180000 aaaatctatt ctttctattc tttttttttt tttttttttt tttttgtgac ggagttttgc 180060 tcttgatgcc caggctggag tgcgatggtg caatcttgtc tcactgcaac ctccgcctcc 180120 tgggttcaag caattctcct gtctcagcct cctgagtagc tgggattaca ggcgcatgcc 180180 accatgctca gctaattttt gtgtttttag tagagatgag gtttcatcat attggtcagg 180240 cttgtcttga attcccgact tgaggtgatc cgccccgctc agcctcccaa agtgctggga 180300 ttacaagtga aatctattct tatattttat tgtaacctca gaaaagaatg cttttttgag 180360 gactagagtt ctgtctcttt tattgtcttc tcctttctct ttcccaaacc tataactcta 180420 ttttgcttag cacacaatga ataatcagat gtcttaaatt gtggcttaca taattactag 180480 tataactttt ttgctttttt ttatttcatt ttaatctgtt catgaggact gttacccagg 180540 tatttaaaaa atctcactcc attgttttaa ggttagtggt tccaaaggga ttttagagac 180600 cctgacccaa taatagttat atttttctaa gtggttctga agcaatggtc acaagtaaga 180660 aactgcagtt caaaacacat cataggtttg ttattttcca aattcttatt aaagcattaa 180720 tgcaaatgga attttcctac tagtattctg ctttctctaa tccttgacag gactaattgc 180780 taaactataa tatgatttat tataatttta tgtttatatt aaaaatatag aatatgattg 180840 ccctttgatg tcaaatacta aagatcctgc tactatttta gttgtgctgg ttcttttctt 180900 ccttatcttt cattcacctt ttcaattcat ctcataaaca tttaatgaaa aacttattgt 180960 gtatcaaggg ttgtttatta tatgatttgt aattcaaaaa ctttctttct ctggtctgag 181020 aattttagaa acatgaaaag aaagagggag ggagaccaac tgagagtata aaaataaatc 181080 tggcatttat taacagttaa ccaatttctt ttttctataa taatttatct actaaactgt 181140 attttttaaa ttattgtttt agtttttgtt gcatatattt aaggtataca acatgatgtt 181200 ttttataatt actagagtga aacaaattaa caaactcatc tcctacatag ttatcttttg 181260 cgtgtatgtg tgtggtaaga gctccagaaa tctactctat taacaaattt ccaatatgca 181320 atacaatatt attaatgata gtctttctgc tgtacgtcag attcctagac ttattcatcc 181380 ttcataactg ctactttgta ccatttgaac tacgttttca catcccctgt gaaaatggga 181440 ggggggccgt accatttgca tggaatatct ttttccatca cttacctttt actgtatgta 181500 tgtactcaga tctaaactga gtttcttgtg gaaaccatac agttggatct tcattcttta 181560 cccattcagc cattctgtat cttttttatt gaggagttta gaccatttac aatttaagta 181620 attattgata gggacagatt taagcttgcc attttgtcaa ctgttttcta tttgtttata 181680 attctttttt ctcttgctct cttcttcagt gttttgttgg atttttatgc tgataggttt 181740 tgatttcttc ttttgtgtaa cttctatata ttttttcttt gttgtcacca aagggcttac 181800 ataaaatatt ttagagttgt aactgtccaa tttatgctga tagcaactta gcttcctttg 181860 cttataagaa ctctctgctt ttacctcttc tcccccatta tatgctacta atatcccaat 181920 gtacatctgt ttatattgtg tatgtagtaa cataatttag ttatagttgt tttaatactt 181980 gtcttttagt ttttatagta gaatgaacat atttacctac cactgttata gtaatacagt 182040 attctgtatt attttttacc aatgtgttcc ctactctgct gctttctttt tgtttcaatt 182100 ttaagagcta tctttggcat ttcttataag gcaaatctag ataaactctc tcaacttttg 182160 tttgtctgag aaattattta tcttgccttt atttttgaag gacaggattg ctgggtatag 182220 ccgtctttgt tgttaggttt tgtgtttttt ttttcttttt tcagcacttg gaatatatca 182280 ttcaactccc ttcaggcctg caaggtttct gcagaaaaat cgtctgataa tactacagag 182340 atttcattat aagtagcaag tcacttctct cttgctgctt tcaaaattct ctttgtcttc 182400 aacttttaac aattataatg tgtcctggcg tgggtctctt tggattcatc ttacttggtg 182460 tcgtttgggc ttcctggatc tggatgttta ttttcttccc gggactggaa aatattcaac 182520 cattatttct ttgaattttt ttctctctct cttctccttt tgtatattcc gtaatatgta 182580 tatgggttca cttgatgtta ttccaaaatt cccttaagct atctttactt ctcttcattc 182640 ttttttcttt ttgcttctct gactggataa tcatcaataa tctgtttttg agttagctga 182700 tcttttcttc tgtttgattt agtcttctct tgaatacctt ctgagtaaaa acaaacaaac 182760 aaactgtttt tcctctgctt tcacagttca acagcaatca gtaaagaagc cctttgtgac 182820 aaaatgtgtg tttagggaag gggtggtttc cttcacacaa caagtaagca atcagttctg 182880 cagtaaatac cagtttggtg tcctctaatt caattccaac acttctactg agagatccta 182940 cagattgggg gctcagtccc cgagactgtc ttcctcaacc aacttccaat gccaattgca 183000 aaccccaggt tattttgcct gtacttctta ctgactggct ataaactgag gttcccacaa 183060 cccccttctg aggttcaatt aatttgcaag agtggctcat ggaacttgga aacacttgct 183120 tatgtttatg agtttattat aaaggatatt ttaagggata caaacaaaca gccagaagaa 183180 gagatgtcta gggtaaggtc aggaagggtc atgagtacag gagcttctgt ccttgtggag 183240 ttggggtaca caacccttcg gacatgtaga tgagttcttg ttcaccttcc tgtaagcctt 183300 cacatgtata gctgtctaga agctctctaa atcctgtact ctttggccat ttatggagac 183360 ctcattggat aggcatgatt gacaatcatg tggaaatgtg attggacaaa aagagtatta 183420 gctagtgcta acagactgaa tggaaaaccc agaaaggcct gtctgttcag attcttcctg 183480 gtctctctct gcagcattct ttcctccagg gaatggggca ggaccttttt tgaaatgaaa 183540 atcttatgac ctacaatcag acaaagtagg tcagagaatt tctttatggc cagaggcagg 183600 ggaagactta agtgtatttt tagtttctgt tgcctgcctt atggagaaaa aggaacaggt 183660 gaatagaggg taagagaaag tcatagagag atttctgttt tttgaggcct gcttctaatg 183720 tctaaagcac cccagcatta taataaaaga ctgtaataag agctaaggaa gttatgagcc 183780 aggaactgtg gacaaagtaa tatcacaccc ctctattttt tttttttttt tagtttactt 183840 actgtattat ttatttccat gatttctgtt tggtactttt taatattttc tatctttttg 183900 ttgaaatctc actttgttca tgcattgctc acataaactc agtgagcatc tttatggctg 183960 ttatttttaa ttctctgtga aatcagttac ctccatttca ttagggtcag tttatagagg 184020 atttatctag ttcttttgtt tgaaatatat tttcctattt ctttattttc cttgactacc 184080 tagagctttc tttaaattat atgaaatagc catctctccc agtcttgtca aactggcttt 184140 gtgtagcaga ggtacctcac caatcaactt gaccagagat ttgtggtgcc tctttttttt 184200 tttttttttt ttttttgaga cagagtttca ctcttgttgc ctaggctgga gtgcaatggt 184260 gccattcagc tcaccccaac ctccacgtcc cgggttcaag tgattcccct gtcccctgtc 184320 tcagcctccc gagtagctgg gattacaggc atgcaccaac acgcccggct aattttgtat 184380 tttttttagt agagatgggg tttctccatg ttggtcaggc tggtgtcgag ctcccgacct 184440 caggtgatcc gtctgcctcg acctcccaaa gtgctgggat tatagatgag agccaccgcg 184500 cccggcctgg ggtgcctctt aaacttttgt gcttattcaa accaccagtt ttgttcttag 184560 tggccctcgg taggaatgtc ccaagtccta agttagtgac caaggtagag aaacctgtcc 184620 ctcaagaagc agctagaaat attggggctc tagatgagtg gtccatcttc ctctctcctc 184680 agggataagc tgggagctgg actttatacc ccactcactc tgcagtccag atagaggatc 184740 tgtgccaaat gcttgtgctc tatttcagac aatgctctct ttaaacattt actttgctct 184800 ctcaaatggc aggtctcatt agctgtcctg gataagtgaa ttagctggaa gcttggttat 184860 gtttctggag tgaggagctg caggaagtgc cctcatgcct gttcagactc ccggagttct 184920 actaattgcc tgctccatca gctccctgat gcaggctaat taatagctta atccacggac 184980 agcagctagg aaagtcagaa tattatgtat gcagtctaac tccgtccagg gagaaactga 185040 gagctgggtg tttttgcttg ctcactcttc actgagcttg gggaactagc tgctggtagt 185100 gcacatgagc tcatttaaaa ccacttcttt gttccttgtg gtcttggggg acacataaat 185160 gccagtcccc catagctccc agagctaggt gatttcagag ccagtctctc aggtgggagc 185220 tgtaaaagtt ggggtgctca atgtatggac aaactccttc caggagagat tagatgcttg 185280 attttatcat tggattgagc tgggggagaa ggcacaggaa gtgcccacac actagtgccc 185340 acatacatac cctttcaagc tcccagaggt cttactaatt acctgcccca ctggctctta 185400 gtccacttag taatgctata aggaatacct gttgctgggt aatttatgag gaagagaggt 185460 ttatttggtt catggttctg caggctgtac aggaagcatg atgctagcat ctgcttccag 185520 tgagggcttc aggctgtttc cactcatggt agaaggttaa ggggagttgg catgtagaaa 185580 tcacatggca agagatgagg caagaaagaa agaggagaag gtgccaggct cttttcaaca 185640 atcggttctc tcgtagaaac taagactgag aacttaacca ctgccctgac aagggcacca 185700 agccataaat gagagatcat tcttatgacc cagacacctc ccacaaggtc cacctcccac 185760 actggggatc aaatttcaac atgaagcttt ctggggccaa acaaactgca tcaaaatcgg 185820 gctcccagtt ttagactatg tagaacttta atccttgggc agcagctggg aaagtgcaat 185880 aaaaccccta ccagagagaa actaggagtt gggcaatatc gcctgttcac tctgtactaa 185940 gcctgaggga attggggtag gaagttcttg cacacctgtt taaaattgcc accttgttct 186000 ctgtggtcca gagataattg caaatgctga gcctatctgc ttccagagct aggtgaattg 186060 gtgattatgg tttggctctg tgtccccacc caaagattga tcatggggac ggtttcttcc 186120 aagcattctc atgatagtga gtgagctctc acaagagctg atgaagtttt aaaggtgttt 186180 ggcagttccc cctttgctca ctttccctct ctcctgccac catgtaagat ttgccttgct 186240 tccccttcac cttccaccat gattataagt ttcctgagcc ctccccagcc atgtggaact 186300 gtgagtcaat taaacctctt tcctttttaa gttacccagt ctcaggtagt ttctttctag 186360 cagggtgaaa acagaataat ataaggagca agtccctcag ggaggagctg taaaagttga 186420 ggtgctatat gtgtggtccc aaccctttaa cttctaagaa ggtaaagcta ggagttgggt 186480 ttccttcctg attacaaagt gatgtgcctg ggtggtgcta ttggtgtgaa ttaaccaatt 186540 tcttaaacat caactaggtg ttccaaactg tgctaagggc tagggaaaag gctttgttat 186600 ccttattctg agagagctta tagtctgatt aggaataaga aaactgacac aaaataacag 186660 caaataacaa ggcaacataa tcagttgcta catgttatgg tggtatataa atgatggtag 186720 aatttagaaa actgaaaggg gacaggatag acaagagtgg tcaggaaggc tgcatggaag 186780 agaaggaact tgatttggga tagaagaagg ggctgggatt tgggaagaca aaacaaaaga 186840 agagggccat tccagtatcc aagtaatgac agatagaggc acagggcatg tattaacacg 186900 agaatagcag aagtttgatg ttggttagaa cttactacca acttcttaca gaactttcct 186960 ctaagaatta tgagtttgaa aacattcaac acctcaatct actttcaaga tttcctggca 187020 aagtgaagga agcaaatacc tttattattt tacaactgaa gttacctgtt ttgtcagtta 187080 tgatctaggc tgattctaac tacctatggg caacctagaa cagtcaaaag agctaggaat 187140 tcattcaaaa gaccaaaatc tgcattgtct ggtagtgtga gcatgagcaa atcacttcat 187200 ctccttgagc cccagttttc tcatctagga atgaaaagta gagccttatc tatctgacca 187260 ggttattatg ctattaagtt atataagtaa atgtgaaaat tcttcttaaa caataaaaca 187320 atataaattt tagttggtac ttttgttaac atctacacta gaccacgttt atataggtaa 187380 tttaaaaata aaaaagaatg gggaattcat tcttatgtca tggatttata ttttttttgt 187440 agtacaaagt taatcgctca gcagtgtttg ttacatttca agtagcaacc atcatattgc 187500 catgaaattt atttagtaac ccctaactac ttttttttta atgaaatagc atagaatgaa 187560 agtatagtgt atattgtact ttttagggca gtagattata tcatttgtca taaagatgag 187620 tgtcgtttag tgacacacaa aggcataagt gacatacaca ctggtcaaaa tgtaaaatat 187680 atttcttttt gtggattgtt gtcaaagaag attgaaagac actaattaat aatatagtat 187740 ttcaaatata aaatcctcag tcttcatatt ttgaaccctc aaattaaact aaccaaaaag 187800 ataaatttca gagaaaagtt attttatgta aagaaagtga gattttgatg aaatgagaca 187860 tgctaccaca tattctttat tttcttctta tgtctcttgc tgaaacccaa attctgtctt 187920 cacttctgct gcccaagtat acaaagcaaa gggatttttt gtgtgtgttt ccatcaaaag 187980 ctacatgcct agaaactcat tgtactctat tttttctggt agctcttgag ttgtttattt 188040 taactatcaa tcaatattat ataatttaaa aataaaaact taatttgtga caaagtaagt 188100 tttcagtctg ggttcaggaa agaaagggat ggcatatgca aaaatgatgt aaccaggaag 188160 aatgcaataa tatgtctatg tacaagaggg gtgatagaat taaggaaacc aaccaaagat 188220 ggtgaagaac ccagagctaa gaaaagggta ctagctccca ggcctgaaag gtcacagtgt 188280 tctaggttcc agaagtgaca ctgagcagtg ggagaggagc aatattacta gtgccatcat 188340 gggaaaccag tcttttcagg aaagagagag gcatggaggg gacaggtgcc aatggctgaa 188400 cccaatgaag accaagggtt ctgggcaatg tcatctgtaa tggccaactt cctggggcac 188460 agagcaggga agacgagagt ggaaaatgag tgtggagcaa caaatgggga gtaaccagca 188520 acctattata tgaatgatca tttttcatgt cagatggtgg catatagctt ttctactcaa 188580 attcagtttc cttcctctgt ttgctaactg gcctagacca atcctgatct agcccatggt 188640 agtttacttt ggttcctagc tgttgggtag ccaaccagtg gtgtcttcct gcaggaactt 188700 cttagaaggg ccaaagataa aggatgaagt gtcctcattg atttcataga cacaaccagt 188760 tctagatcac tggttcaaag agggtaataa attagtaaag tgggagaaca cgaaattagg 188820 aagattcatt tctgctttat tgtgaactgg gtcaattttt gctttcttaa tattaatctt 188880 gaaaaagata tcctttgaaa tctcaaaatc cttttctgta atttaaaaac aaccttacca 188940 tctgtgtcct ctgtcatatg gtacaatatt caagagggtg aaataatggt ccagtgacta 189000 agaaaaacct taaaggataa attggcctta gtgactgtca ctaaaatgta aacatggctt 189060 taaaaagtaa atcaggaggc atgaaagggc cttgacagct aaggctctca ggaagggtct 189120 agaaagacat gaagcacaat tttataagtg tgatatagga gttactcttc tttttttatt 189180 catgtgtcat agaagggaaa ggaaatttct aaaggagtaa gaccagccag atatcacaag 189240 aatatacagg aatgtaagga tagcatgttc aagggcaaca tgaggagtca aagaaaatgt 189300 cctggatgcc aagactagct gtgttcttgc agctgctggc tcctccttgg caaacacacc 189360 attggcaatg aactgatctg atgtgaaccc ctctaagtcc ttgagactct ctttttattg 189420 caaagcttgc cagcctcttt acccagtaca tgtactccac tctaagaaga aaaaacaaaa 189480 ctaagtgact gctaagctca tggacaatgt ttttgggtct ctccagcagc cagctagtgg 189540 ctgactaggt aaaatcattt atttttctca agatgttgtg attctgggaa tgcagggttt 189600 ggctgccatg ttagcctgga ttttctgaga tgcatccctg caagagattc actgggaaat 189660 tagatgtgca agagatttat ctggggaaat gcctatgagg gaaaatggag aaggagctgc 189720 agaaggctgg aagagatgac cactgcagta caggtctaat cccagtggaa aaaaaaaaag 189780 gagagaagga atgagaaaag ggaaagagag aaggagggaa gaaaggaaag aggtagggag 189840 ggagggaaag tcttagacat cagtgcagtg ccaagaaagt tttggcaagg ctgatgggga 189900 gtcttcaaac caaagtcact tgaaagagga atcccctcat catccctcta ggaatgggcc 189960 tgccttggtg tccttgtcat gcaaagtcac tggctgggtg gatttcagag catagcagct 190020 gagggcatag gccagttaca ctctgccata ggaggcttga gagatgcatt ttcatagctg 190080 ccacatttgc cactgaaacc ttctgggagt gatgggttgt gctggaagaa tttgaagata 190140 ctatcttatg ctccagataa agaaatgcat tgatgaaggc ccttcactat tagatttatt 190200 tttgtgtgtc ccaactatta tataaattcc cctatcaagg aattttcagt gttttctcct 190260 tgcccttaga tatgtgatct tatatcccag gtttgctgag acattcctct tacagatagt 190320 tctactggct catgagtgta atgtgtctaa atgtatggtt ggaaaaatgt ggttattaga 190380 tctaaatttt aagtccaaat ttccttagcc tgaagtttag agtcttccac agtctagtcc 190440 caaccacttt ttccaacctt aattaccatt gcactttatc ctgtatttca attcatttga 190500 aatatttgct cctttctaaa ttactcttgc ttacccacca ctatctcttt gttcatactg 190560 ttctcttcaa ctaaggttaa ttaatcaaca tgtatttatt gcccccttcc catgggccaa 190620 gccctgtgct tagaactgta tgttagggga caaaacgcac atggtttctg tcttcttaga 190680 gtttgaattt agtagaagag gaacagacaa atacacaggt caatggacag tgcatgctta 190740 caaatcatgt gacagtgtca aaagtaaaca aagagggttc cctgacagag aattagagga 190800 aggttttatt ttagatagag ctatcaggaa agaaatggca tttcagctgg aacttgaatg 190860 ataaagggaa tgtagttact aaggacttaa gtcctgcagg taccagttcc atcatcttca 190920 agatattgcc atgatcttca caaaatcttt actgactcat cattggactc tcaaccaatt 190980 ttagccctgt gctatctgca tcttttatat cacagaaagt gttgaagttc atactatata 191040 ctaaatgtgt ttgtctccaa tcagactata agattgtgga atgttagacc catgtgtgat 191100 gtatgccttt gtatcctatc agattatatg attttggaag gttagagcta tgtctgtatc 191160 cagcataata tttatctctg tatctgcatg atacttagga taatagtatg tggccacatc 191220 caacaaatac ttgttgaatg aataaacagt attccactct ctgcaaattt ggtctttctg 191280 acatttgtct gaattataga aggagaagga ggctttacat aatagttgaa aattactgtt 191340 catgtaatac agagttctga acttcaacca gaagcaagtc tacagcagat gaaaacattt 191400 gtaatgaggg aattagctgt ggataacttt cggataggat gttataagtt tagcatttgt 191460 attaaaatcc attattatat gcataattaa gttttaggaa gaaaatctgg ctgaatagta 191520 aacaattact attttcaaac agttcttcag cagttagtta ccactggctt ctagaattta 191580 actgttgttt tttttaatat atcaaactag catgtgggtt gagacacaac atcacattac 191640 aaatgggtag tcccttcact tgtagatcaa tcagtaataa tatagatact gatttttaca 191700 gtttgtaaaa ttattgtcat ttctttctct tattatctgt attctcagaa acaaagagta 191760 taaacaaaga gaaagggcat gatgtatttt tgataggcta ccatctcaaa ttttcatttc 191820 aatgtttatt tggagaaaca cttttatcta aaatggacct tttccatttt acaattgcac 191880 ttgctctcag aatgagaact gcaccttcca ggagagattt caatctgact ccaaagcctt 191940 gaccctcaca aacagtgttg tttgtaatgg cccctggtta gaaactctca gcctaacaag 192000 catgcagcat agcccctgaa gtctctcctc ctatctgcat aaattgggga tgtagaactc 192060 ctgcatatcc agcctcactt actcataaaa tgctgggaat cattccaaat tgctcttcca 192120 gaggagggtt tgtttttaaa attatttcag atagagatgt ttcaaattct acataaatgc 192180 ataatattat ttctgattgt gctttcttgg tatttctctt cctgtaacac ctacttagcc 192240 attctccagg gaccacttca aggacttttg taatccatat agctttccta agctgttcta 192300 actttcagca atcccaacca catcactgac cgagtttgta atgactcacc agacaatgtg 192360 ttgggtcctc tagtaatact ttgttaattc caagttatcc ttgctgctgt tgtttctccg 192420 tgtgtgtttc tatctgcgct ctccagttaa gctgtaatca acttaaccac tgggctttgt 192480 cttatactct acttctcaca acccttgcct cttaaattgg ttaatgtatg tttgatgact 192540 aattgtacac ataatagcta cttgataaat gttcttaaga aagggacaaa ttaagtattt 192600 tccctgataa tcctctatac caggcatcgc tgtggaaagc tgcacagttg ggaaagcgtc 192660 atttcaaaaa caggaaaaat cacctgtaaa ttatttcagg gatttgactt tgacattatg 192720 ttgacataaa agaggcttaa gaacagctat tagaaaatag aaacagataa atgaatgagt 192780 gaatggcata cctaaatggc atgaaatgtg aaaatgatac aaaatgttaa ggtaatcctt 192840 ttttcttctc taattaatct ccactgggta tggggaatag ggaacaactg gggtattcgt 192900 aacaggcaaa cattcctgat tcttgcccta ctaaaggtag ggacattagg agaaaggatc 192960 atctacttgg aaaataaact ggcattgcta agtctaaatg attgagtcaa gtgcaaattt 193020 tataggccaa atagaatttt cacaagtcca ttgactgttg aaaactactt gtaccctggc 193080 tcaaaggaca ttttcttgct gtctgtagta agcggtctgt aaactgtgtt taggacctga 193140 accgaatgct ggcctttcac ttctcaaact atagcttagt aatcccagct cagaagtccc 193200 tccatacaca atttagtaaa attaacatca gagcataacc atgctttgtt ccctccagaa 193260 gtaaaatgtg aagtttcttc ccattggaag tctatttatt attagtttca gatgttgtga 193320 caccgttttc atccaaatgt tagagaacag aaagaagcct tttttaaaag cgtaactttc 193380 attattcatc taggtttttt tcagggtcct tgagaaatgc taagattatg ccttgtgttt 193440 gagaagtaga aaaggaaaaa gggaggaaaa ccacctagag aagtgcttct caaactttaa 193500 ggcacacatg aatcacctgg ggaccttgca gattctgatt ctgaaggtca gaggtggggc 193560 ctgacatcct gcatttctaa cgagcttcca ggggatgctg atgctgctgg cccacagacc 193620 atactaccta gagcagcaag ctttataggc catagaggac attttttttt tttttttttt 193680 tttttttttt tttgcatgga gcacagatta ctgctctact ctaggttaca attccaagga 193740 aataatgact aaagaaaaat actgctgttt caacatttct gagtcattta gtaagaatgg 193800 aaggttaaca ttagcaattt aacatttcaa atgtggtggg agtatttatt gatgtactaa 193860 tttgcatttt gttcctgcca aatcttttta ctctgttggc tccagggagt ttgaaagtct 193920 aggacagaat ttttcttcct aggtttgttt acatattgtg gaaaagaagt gagcatcttt 193980 ggagttaagg agagttaaga cccaaggaga agaaagaaaa agactatgaa agatttttaa 194040 aatgtttatc cctgtgtaag atctccaaag cccctccctt gacccagtag tagcaaatgg 194100 agccacagtg atggctgaaa ttgaatatcc cactaacttg gtaaaagttg ggcaggctcc 194160 cagtcagact taaatcattt tagagaagta caataatgtg gcattccttg caccctggtg 194220 atatgcagaa aatacatacc tgcttccgac gaaatttaaa catggactgt taacaagaat 194280 gtacccttaa agttttgtaa actctacagc aaagaaaaaa aaaactgcta cagaaaaaat 194340 aaggattttt tttctagctt taccagcgac ctatactttc atttcttcat gttactaatt 194400 acagaaactt tcagcagaaa tgtatcactc ttgggcatca gttagttcta aacattttag 194460 ctcttaggag cctctgatga catctgttct gttgttagtt ttgctccctg actagattgt 194520 aacttctaag ctcaggaatc atgtctgcaa ctacttttct ttagtcctaa cctaaccaag 194580 agctaggcat ttaggaaatg ctcactataa atgtattgac aaatgattat gtataattag 194640 ctcttcatca caatattttt catcatcaag aaatagattt aaaggagata ttttcaaaca 194700 gtatggatgt atcatcccct tacctttatg tatgtgtctg gttgtgaata gtcagcacat 194760 attatggtta aactcaagaa acaagggagg ttattttcta agcctgcatc atagcagtag 194820 aaatttggaa aaaaacaaaa aacaaaaaaa aaaaaacata gaattaattg agttgtaatc 194880 aaagaaaatt atgtgactat aaattgtaat atttctaaaa tatacccaca tatgccaatc 194940 tattgtaaga aaatgttcgc agagggaaaa caatggaaat tcctagaagc tttagataga 195000 ttctaatgat tggaaataag tattacaaat ggtccacatt ttaatgtgac ttctagaatt 195060 ttttagaagt catagtatcc tttcacgctc ttatgctgct tgcttacaac atacacttgg 195120 gtcacgtttt tctgttagga aatatcatac taatgatttg tgatcatatt taccacttgg 195180 ggatcttggt ggccatgata aggaatttgg actttattct gattacatgg gaagccacta 195240 gagaatttta gccagtgagg tagcatgatc ttacttatgc cttaaaaagg ttaattgttt 195300 tggtagttaa ttgaaggaag gcaaaagtgg aagtaggaag tctagttagg aaactatttg 195360 attgttcggg aaaaaggtgc tggatgcatg ggctataata atagcaaagg agatggagag 195420 aagtgaatgg attgagatgg aactgaaaga acttgttgat ggttaaatga gttggaagga 195480 gttagagaaa gcaaagtgac aaagatgact cagaagtgtt tggcttaagt acctgagtgg 195540 atggtgaaac aattttcaga catagagaag aatttaggaa gaacagtttt tttcagacat 195600 tgctcgagag ttctgtgtta ggattgagat acctattaga taccaactga agatactgaa 195660 gaggctgagt agagtctgaa gttcaatgga gaggctcaga ctaagataga aatttggaac 195720 catcaatgtg tagatgatat ttaaagccat gagactcgat gagattccct ttgcagggga 195780 aaaaaaaaaa aaagctagaa tattggaggg aagagttttg taacaggaca atatttatgg 195840 gtcgggcaga ggaaaagaag ccagtaaagg agaccaagaa agaacagtcg gtgagctaga 195900 agggacacca agtggctcag gcatcctcaa agctaagcaa agagcatatt tttaaaagac 195960 agtaatgtac tgggtcaaat gcctctgaga agttaagtaa tataagaaat aagaagggac 196020 tattgaattt gatatgaaca ggtttagtgg aatggaagga ttagaagtaa aaccaaagta 196080 gattcagaag aggagaaatt aggaagtaga gacagccatt cagacaagga cttaaaagat 196140 ccaggaatgg aaaggaaatt cctgggagcg caacccctaa gaagccaaaa atagagtatg 196200 ctttccatgt aggtttttaa ttcttttttg gtggtgttct ttagaaagag aaatgtctgt 196260 tgggattatt gtttgaaatg gtgttggggg cccaaccatt tctggcttct atagatcccc 196320 tttttgtaca tgctcattcc cttaaaaaaa aaaaagaaga agaagactag attttctaat 196380 ttagggcaag gggctaatag caaaccaaac tcatttgtaa tctaaatggt cacatattat 196440 tttggttgct cttcagtggc actagctgct gctaggaagt tcattttaca cacacacaca 196500 cacacacaca cacacacaca cacacacagc atttgctgca gatcctaaac ttgaagccct 196560 ggatcttcct tacatcattt acccagaagt atctttgtca accttcttaa cttacatcca 196620 ccagaaagta gaacaaggca gaagttgtgt gggagttctg ttcctcccca tttcccccct 196680 cacctgctgg cgtcagcaca ataaatactg tgttcagaac ttggctaact gcttcttttc 196740 ccacattcga tcagggaata cttaaagcca tacagtgtcc ttgttctgcc aaaaagcata 196800 tggggcaggt tgccccttca ggctgacaca aagacacact gtgcaagaca tctatggcca 196860 gtggagtggc cgtgtatggg ttatcaatga gacttttgac ttttttcttt atgtcatatt 196920 gtcatcacat taaatagaat tcaaacaagg aaacaaaatt tatattctag acttttaagg 196980 cattgcctgc cctatagcta tgaaactttt ctttttcata cctggtataa ttttccactt 197040 taaacaatgt tgtgtgattt gattaccgtt ttgactctca tttaattgtc cattttaaaa 197100 attttaactg aagttagatt tagatttaaa gttcaatacc cataaaggat acttctcaat 197160 agagccgaga acttcagaag gcacaacaaa aaaagggcaa agttcaaaaa actaagcatc 197220 aggtagctac tttttactgc ccagggacat gtctaggtaa actgtcacca tatccatcta 197280 catttgcttg ctagtagagc ttccattttc tactgcaaaa tagtttctgg aaccacttcc 197340 atgttggcca aaagagagtg tcaacaattc ctttccaaaa ttgaccttta gaaagtgaat 197400 ctaaaatgtt tgattcaagt atgtgagggg agctgcatca aagttttcat ttttactaca 197460 tacaaaagtg acagataaat ccgtaaaatg tatgcatttt tctgctaaga ctgctaatta 197520 atttaaaaag agattgttag aataaaaggt cagagagtaa acatattaca gatatttatt 197580 gagagcctgc tgtgtgcaga gttggaaaaa ataaaatgag gttgctcctt tcaacagact 197640 tacaatctaa ttgagggagc gacagcataa atgtatgcaa agcaaataat gcaagataca 197700 gcataagaca taattaacta tcagatgagt gacatatata ataaatacca ttaattcaca 197760 ggcaatcgta atcagaagca cttaacttac tatgtgccag gcattctgct cagtacttca 197820 catacattat ttcatttttt tgaaatatta tttctacttt atagatggga attggctctg 197880 atcttccccc tattctggag aaagcaagga taatggtgta aggtagacaa agacccaagc 197940 agacatgttg gtctggggca aaggtccatt taagggaatg gagagaaatg aaccctgggg 198000 ccagcattag tctgtttaca accatatccc agtgcctagt atagtgcctt gcacataata 198060 agtgctcaat aatatgtctt gaaaaaacaa atggccctct ggtctgtgcc tgtaatccag 198120 atcaagtacc atggaataaa gttaattagt gaattaaagc cacataccac atagcttaag 198180 gacccatccc caagacctcc caattcccaa ctatgacaat aaaggattgc agtggaaaag 198240 atacatcata aggggaatag caatagcaat tccagctcac tggggtctat ttcatggaat 198300 ctgacatggt gaacagttca taagtttatt tccaggctgc aagaccctgc aacatctggc 198360 ctcttgcacc tccacaacct caaatccttc tattcttctc tcactctctc tactcctgcc 198420 acacatacct cccttctact cctcaaaccc atttcagggc ctatattctt gcttcatatt 198480 gcctggaatg ttcttccaca aaacatctgt gtggctcatt accatacctt cagatctata 198540 acagccactc tccccacatc ttcccagctg cctgacatta taatacacat ctatttcctt 198600 atgtgttcat ccccgtacac actagaacat gggcccagga aggcagaatt ccatctgctg 198660 tttttgccat tgaatgccca gcaactagga cagtgcctgg cacattgtaa gtactcacac 198720 acagcaactc taactcagga ttactttttc tagctctgaa atacctactt ccaagagaac 198780 gaaatttatt caagaaatgt tggatggaaa ttgaagagtg agcttggaaa cgagacacag 198840 agtggcagga gcccagacca acctgtttat gaaagatgcc tttgcccata gagggaaaaa 198900 tacaccttaa aacctctgcc aaagtatatg ctttcttagg acacctctga catgctgaat 198960 tgcacctggt ctgaacaaga tctatgaatt tgccaaaaca actaattcct gtgatttaag 199020 agtcactact accagtatca gcctagtaaa caagtaccaa gcaacgagca ccacatatgt 199080 cagtatccaa agacaaacat gctgctgcat gcaaaaccag acaaatgcat tcacgcgggt 199140 gacagtgagt ggaagaaatt aatcttattt ttattatttt ttcccttatc aaacactagc 199200 aagggactag atgtcataaa tctagttaaa atatgttgac tttgcctcaa atttgagcat 199260 tcatggttcc aaaaggacac ttgttatagg atctgatgat gtactttaga atcttctttt 199320 gtgcaaattg agacttcaga gaactcaaaa tatatggtaa attcaaagta atattataag 199380 taaaatcata atgcctcaca acattttttg aaagttaaat atttagtaat tttacaaata 199440 tgtattgagc actccctata tttaaggaac tatgctaatg ctgtgatgga tcaaaaggag 199500 aataagccat gatccttacc ttcagacttc aagcttatta ttcattgggc agttagataa 199560 ctaacatatc agacatggaa taataagtgc cattgtccag atattaaaaa caaaattggt 199620 gttgtggaag caaaaagaat gtagagatgg atcccaacta ggagaaagaa aaattgcttc 199680 ctaaagaaga cacagattga ccatgaaagg tggatggttc tacacaggac tagaaggtag 199740 gaattcttca tttgttggac ttgctaattt tttttggtgt aaatataccc actgttgttg 199800 atttaaagtt gataacgtga tgcaactgaa cacagaactg ggaagagaag gtggctccag 199860 cacgctacct atgagtcacc agctgagctc cagacttaat taaatcaacc tcctcactac 199920 tattttgaat gagtgaattc acaagtctta aaaagatcta tgataacatt ataagggaag 199980 agatagtcac ttctgtcatt ctcccttaca tctccatctc accttccaat attctgtttg 200040 aatatccttc caatttcagt catatgttcc tggctggcct acctaggatt aatattggcc 200100 cagtgccaaa atgtgattct atttattcct tttagcattg ctgtgattaa tctgcgctcc 200160 tgttatccca tggcatagca aactctctta ctgattatgg cctggtattg acacctctgc 200220 tgttctccat aacgaaaagc agcttttggg gtggctagct gggcaggatg ttttgctgct 200280 cttgtaacag taggaaggaa aagctggagg aattactggg aagctttgca gaaggaagat 200340 acaggccagc tgagagccag cattcatatt gcctgttcct ttcagtattc tttgtgaaaa 200400 caccaccacc aatgtgttcc ctggacgtca ctactgcacc tttaactggc cttattatgc 200460 tagggactgc atttgaaaag ccaaactcta gtatctgtct gtaattgcaa gcggatatct 200520 cagcacatgc acaagcttat gtcaggagga tgtttatgaa aaactcacca agcagaacac 200580 tgctagacag gaaataaata tgtgaagctt gaagttgtta ggaaacttcc acatttgtcc 200640 ctctaagcca gagataggac ctgtgagaaa agaaggtctt tatcattgcg cattgattct 200700 tgctgaaccc ctgctattct caaaatacat ttacagcaaa atgtggctac tgcagatgta 200760 tttaaacatg tgctttttta aatgacactg gtttatcttc caagtttgtt atctactatt 200820 ttactgtaaa gcattaaaaa gtgtttgaaa ccaccagcac catttcacag ttcctgtttt 200880 atttgtttaa attctctagc tcatgtaata tgctgtatga tttactgttc aagtagagaa 200940 gaaatacact ccctcatgga gatgtgggga ggtaatactg tctcttggaa gggctcagag 201000 atttcctgtt tagattacac aggcttcttt agagctgcca agagtcataa catgtacgag 201060 ataatacact ttggttcagg aaaaactatg gataggaatg taattaattc actgagccac 201120 aaaagatatt ccagcttaga aatgtcactg cactcaggcc tggtggactc agtatgccaa 201180 ggggtagcca tgaccaaaaa gaggattgct gcctgaggac ccactgagta gtatccaacc 201240 acagagcaaa aggagggggc ctggctgcta aggacatcac acgtctcacc tgcttctttg 201300 agaattgatc cctgaagggt atttctgccc aaagcctcag caacctggct tcatcaatat 201360 aactttgtga tgcttgtgac attgagatca atcaatcagc atgtacttta tcaagtgcct 201420 cctcatgagt accaattgtg gcacatagtg gggaaaccct agaggcagag ccctgcagag 201480 gatatggtga ttctgaccag agcaagaagg tatagtgaaa agtttcctaa atatattttg 201540 tgtcttgtca taagaatcac ctggcaggga ggggtatgga agggcaaggt aagcatacac 201600 attcccagga cctttccaaa atgtagagtg accagggact tagagattca gactctatca 201660 atctggggca gggccctaga cttggtatat ttaataactg ctgtgtgagg ccctttacat 201720 gcatgacctc ctgtaattgt atagcttggt tgctgtatat ggtactatgt ttacttgtgt 201780 ttgcactgtc tattcagggg tgtttctaaa tgccattgct acacaactgg tgaattatga 201840 ttcttgccag aacattgatt ctcctactct tgcttcctta atgacacact agagaactgg 201900 gattggctgc atttagtctc aggatgaatc attgccataa gtagatttcc atcccctact 201960 ccaccaactc atttgccaaa cacccttaaa gaacagaacc cactgcctac atgcagcctg 202020 caccaggagg gcctaaatgg tctagctggg tttatgacaa catcccgtct tcacatcagc 202080 aaaaccctaa gtgcacaaag tctaatgtaa acacaatgtc aagttctcca taggaaaaga 202140 catgtccctg ctgtcaaggt agtgactagc aataataata atgacaaaaa caataacaat 202200 gataagcata tataacactt acttatcact aattatattg taaatgaaat gatttgcatg 202260 tactaactga tttaaatctt atatatatat agatactttt actctctcaa ttttaaacac 202320 agagaaacca agacctagat acgtgtttct gttgagaagt tgagtacaag gttgagtgta 202380 agtagggaaa gttcaactgc agtcagttct agtcttggta agtacactgt gaggcgctcc 202440 accccaagca tagcaaatta atggttcccc agtgtttgca gaatcaaaat taagttcttt 202500 ggctaggttc tccctgatgt gcccctgctt cttccctaat tcaacacatc cccagctcca 202560 tccatgcatt cccaacacat cacagctctt tacatgccca ggctgtgtct tctgcacctt 202620 tgtaccttct gcacctttgt ttccttggcc ccaactgccc tttcttttcc tccacattac 202680 cctttatccc aaatttagca cctgtctcaa ggagtcacct tcccaaggaa gtttctccaa 202740 atttgttaac agatattcca ttgttcctcc aatgcttgac cactcttcct ttatagatcc 202800 ctgcctagaa aaatgtgggc tcactgaggc caggggctgc agctagttta ttttataacc 202860 cagcatttaa aagtgcctat ttattgattt gttgggaata gttaataaat ggagtccttg 202920 cagatcataa ccaagaccac agttcgtaat ggtttcatta actttgttac tattggatgt 202980 gattctctgc ttatggtctt cctttacttg tttttccctt actgctcagc acctctagac 203040 attaggtaca tggctctgat gctaattaaa attgatgact gagaatgaca cttccatttg 203100 ctaagccagc gcagttttgt tcattgtgct ttacttttta accagcaccc ttagcataaa 203160 tctgtagtct ttccatgagg gtaccatttg ttccttttat gtctcgattc attacatatt 203220 ttcaggactg ttagctgact aagacttttt gctttgtgaa aatgtcacca aatgcacgat 203280 aaaggcaaag tcacaagatg tctgtttgca aaaagaatta aatgctggtt tgtgaagatt 203340 caaggctggc cagggctccc caagcatttc caggccagag ctttggctct gcactctcct 203400 taggatctca taactgaccc ccacattcca tttctgccat cgtggaaaaa tttgtcaact 203460 ttactgctga tgttaggcct ggaaattgtc atccattagt tttctcagat tcaagctgaa 203520 aattgagaca aacttcctac gtaattttga ccaaaataac acatatgttt atgtgctatc 203580 ccatgattaa catattttta aaaccacttt attgaggtat ggttggcata caaaaatctg 203640 tgcatattta atgtatacag cttcatgaat ttggagataa gtatacatcc atgaaattat 203700 tactgcatgt atgccataaa cctatcacct acaaaaattt cctttcactt tgttattatt 203760 ttgattaact taattttttt cttcctttga actatcaaaa ctttctcaag taatacatag 203820 ttgtcagtta tacaaactta ctgaaccttg accaaaggtc ctcttttagt gctcatctta 203880 gagaaagaat taatgaaaca aagtgttctc tgatttgtag caaagatctg tgatggtggt 203940 gggaatggtt ctagaaaata atggtaataa taaaaactta gagtatcaaa gcagcaagta 204000 gatttgaagg aattgttaca atgcaatttt gctttcccgc cactttaaaa tcaaggtgta 204060 gtactttatt tactttagga aaatgtttgc tttttgtcat aattccttat tgcatatgag 204120 agtaaatgat ctatagatga agataataat aaaatttaga gagagaataa aaaagaaaca 204180 ctttcacagc tgaaaggctg cttcccagtt agctaactgg gaggagttac tgaaaaagta 204240 cattgaaaag cggctcaggg gcaggtgaat tggactcacc aggctctgac attcagagag 204300 atgggaatga gtcagctcac tgtccagcac atctttattt tatttctctt tcttgtttta 204360 tatcagaaat agatttcttg gcattgttac tgtgggtttc tattaaggac tgaaacaaaa 204420 gtattaataa tctgagagta tgtaaaaaaa aaattcattt tctcctacta tactctcata 204480 acacagaata ttttggtgac cagagatcac caaaatgtgt gtggtgtcaa cgaaaagagt 204540 caaactctct aaaatatttg aagagatttt ttctgagcca aatgtgagtg aacatggcct 204600 gtgacatagc cctcaggagg tcctgagaac atgtgcccaa ggtggtcagg gtacagcttg 204660 gttttatata ttttagggag gcataagaca tcaatcaaat acatttaaga aatacgttga 204720 tttggttcag aaaggcagga caactcaaat ggggggcttc caggctatag gtaaatttaa 204780 acattttctg gttgacaatt agttgagttt gtctgaagac ctgggattaa tggaaaggac 204840 tattcaggtt aagatatgtt tcttattgga cctaaaactg tgcctggctc ttagttgatt 204900 actgcctgga tctgggaagg aaggaaggaa aacaaagggg gaaggggatt ctctatagaa 204960 tgtggatttt tcccataaga gactttgtag ggcaatttca aggcatggca aggaaatata 205020 ctttggggct aatatttttt ccttgtctca taatgttatg ccagagtcat attgaaaagc 205080 aagtcacaat atacaaggtc aaataaaacc catcctgatg agaacccatg gtttgtaggg 205140 catgactccc cagaaccctt aggtaggaat ttgggcaaga taaaaaatcg gaacttagtc 205200 ctcggtggga atctctcccc acacaaattc tccaacagat tcttcagtgg gacaccaact 205260 gggtgttctc aaattcaatt caattctgac aatctaccta tctacctgga aatagcatca 205320 gataaccaca ggtttacggc tcattccaac aatactgtcc cccacttcag atgccaactg 205380 caagtaatag gttgttacct atacttctag ccagtcagct gtaaattggt gttcccacaa 205440 cctccccctc cggtttgata atttgagaca gcttgcttac atgtaccagc ttattagaaa 205500 ggatattaca aaggacacag atgaagagat ggatagggta aggtatgtgg gttggagttg 205560 cagagtttcc atgacctctc tgagtgcagc atcttcatgt gttcagctat ccagaatctc 205620 tcggattaag acattggcca ctggtgatca aattaacctt gagtccctct ccccttcctg 205680 aggttggaga gtggggctga agtgtctcaa cctctaatca actcttggtc tttcctgtga 205740 ccatgcccca tcctgaggct ctccaggagc ccccaggcat cagtcaactc attagcatac 205800 gaaagacact tatcactaca gagattcgaa ggattttagg aactgtgtca agaaacggag 205860 acaaggtcaa atatgtattt cacaatatca ccagtagttt cactgggagg taaaactcag 205920 tgtttactgt gggcctgagc catgctgacc ctctaagaat aacttagagg taacgtgatc 205980 agatgtgggg aattctggag aaacaccttt caccaccaag cccagacaag agatgcatac 206040 ttttctagct gggatgctta caaagcaacc cactctaata cttcaaggta gagtgacact 206100 acattcatca tttttcattt tttcctgttt tttatgccat ctactactaa tgtcaatcaa 206160 attacgactg tgtttatagt ggatgaatta tggaccatct cacaccataa agttctgttt 206220 ctctcatgtt gagcttttca cctcccttca ttccctccct acttccagga tcattcacat 206280 gtttatttct aaaaataaac tttttttact gaactttttt tcatactgtt taaaaagaat 206340 ttatatttct cttcattctt acagataaga ttcaagttta aactcaaata atgtaggaaa 206400 tcttttttta aaaaattgtt ccctactgtg tctaggcgtg agaccaaaag taattaagac 206460 caggttttca tttgctgtga tttgtgtgag ttctttttag aggttaggtg caattttaat 206520 ttttaaaagg gggattatta tgagaggaga aatcatactt tatcatttga aaatgatgcc 206580 ataacaggtg ttagcagaaa aatcaaactg taaaatattt taaagagatt tattctgagc 206640 caatataagt gactgtggcc ccattgaaat gagcgagttc cctgatccct ctcacagagc 206700 ttgcgacagg gatgtggctc acctgttcag ttgccccact gctcaaaccc ctagggggag 206760 aatacagacg gtcaggtgca aaggctgggg caagtgcctt ggccccttgg ccccttagcc 206820 ccgaggtagt gtctaggggt ggggtgcctg caaccccagt gttacaaagt tctttcagct 206880 ttgcagtcca cggacagctt gagtgttaat cagctcaatg gaccctctgc cttatagcaa 206940 aggcagaggg ccagtgtgac agctttctgt atcccaagct cttgcccagt gtcctagaaa 207000 aaacagatca tacaggggct cgaaggatga gtgcaaggtt ttattgagta gtggaggtgg 207060 ctctcagcaa gatggatggg gagtgggaag tggggatgga gtgggaaggt gaacttcctc 207120 tgaagtcggg cagcccagtg gctggactct tctccaacct cccccaggca agctcctctc 207180 agcgtccaga tgttcctctt ccctctctct ctctgccgca tcatttcacc atctgtctgc 207240 tggtcagctg gcttgctggt gtgctggtct gttggtctgc tggtctgctt ctggaacctc 207300 aggttcagag tttatatgag tgcacgatag ggggtgtttt gggccaaaag gtagcttttt 207360 ggacatgaaa acggaaatgc ctgttcccat ttagggctgc aggtcttcag gcttgagggt 207420 ggggcctttg cccaggaact accctcttct acccagtgtt tccctgtctc ctgtccatat 207480 caccagtatt cacagtctca aggagtcttg agaaagtgtg cccaaggccg tcagattcag 207540 tttggttctg tatgtttcag ggaggcagga attacaggca aagacataaa tcagtacatg 207600 gaaggtatac attggttcac tctgaaaagg caggatgtct tgaagtgggg acttgcaggt 207660 catagtttgg ttcagagatt ctttaatctg cagttggtta aaggaacaaa actgtacaga 207720 agcttcgagt tagcaaaaag aaatatttaa attaagataa ggatgctatg tcagagtcag 207780 ccacaaaatg acctgtttag caagattaat ggcctatagg tgtgacttaa cccttgcctt 207840 gcatggccta aggtcttgtt tataatttag tatcttattg cccaaagagt ctatttagtc 207900 agtcttatga tctctacttt aacattaatg ctggtcactt gtgcctaaac tccaaagggg 207960 aggtatatcc aacctgcctt cccattgtgg ccaggaacct ttctctggag tccccttggc 208020 caagaagggg tccattcggt tggtttggga agctgaggat tttgttttta gtttacacag 208080 ggtcatatca gattgttttg atggggatga ctaatggttt tcttctcttt ctgtttcagc 208140 cacagcagct atccttagca gagcaccctg gagtctgcaa agtgttaatc caggcctaaa 208200 gacaagtaag aatttcagtc ctttttcttc cttcaatgat attttccatg ttttagtgta 208260 attaagctac tatcctttct ctattttatt tgggatggta gtaactggaa tagtgactga 208320 gttgaaattt tataggcaag caaaacattt tttaaggatt tattttttaa cttctgatat 208380 agtttggatg tttgtccctt ccaaatctca tgtaatcccc aatgttggaa gtggagactg 208440 ggaggagatg tttgggtcat gtgggcagat tcctcatgaa tggtttagca ccctcctctt 208500 tgtgctgtcc tcaccatgag tgagttctca tgagatctgg ttgtttaaaa gtgtgtggca 208560 cctccccctt caatctcttg ctcccactct cgccctgtga gacacctgct ccgcttcacc 208620 atgattatag gcttcctgag gctttcacca gaagcagatg ctaatacagc ctgcagaact 208680 gtgagccatt taaatcattt ttctttataa attacccagc ctcaggtact tttttatagc 208740 aatgaaaaca aactaataca acttctgtgc aaggctgctt ttttttctat tttttgcttg 208800 tgcttggagg ttaagtaagg ccaaattaat gaaggaggaa aaaagaggaa atgatacatc 208860 atggatcaac aattatttat tgaatttagg aaactgcctc tttttataaa ttctttttaa 208920 aattattttc attattatct tgaagtattt atctaaggtt tacactggta gaaagttaaa 208980 cttgtctctc caaccaaatt gccttaagct tcaaaattat gccttattgt aagctctttc 209040 ttaaccttaa aatgacttta cacattcccc gctggtcctt tgacaatctc ctcttcaacc 209100 acaagacaga accccaccat caactctgtg gggaagcgtc tccaaattct ctagtcctga 209160 acaacattct gccttctctg cttccatgga actttgtcct ttacaacatg atagcgtttg 209220 cctcctgaca ttttagtgtg tgtgttagcc ctgcatatag aactcaccag attgtgtgga 209280 ctgcatgaat gaattaattc tattgaactt taaggcaaag cctaaacttt atgcttcttc 209340 taaatccctt acatctccta aaaaaattct gatccatagt agtaggtact tgtttaatta 209400 aattttaggg atggatattt ttcatcagtg gaagtatatg ctagagtcca tattatgcaa 209460 taagggaagg gaagacagtg tacctaaatc agttaagata ttgctattct tgttgttatt 209520 ctagagtcac gaaatcataa tttgaatttt atgactaaat tgcagaatta atttccaatg 209580 tgagatttta acattatttc cttggaggtg accaaaaagg agagctggta ctgtttttaa 209640 caactgtcat tcaattgtca gttgtgccag accacaaatc ctttatagcc ctcctgttta 209700 agaagcatct gacatgttaa gctgctccct aattaacaca gaggttgtaa aagaagtggc 209760 tgtttggttc tgtttgggtt tcccagccag tatattccaa agcctttttt cactcaacag 209820 atgagttatg tgctttatat tctgtaagga aatgagaagt aatcagttga aaatgtgtta 209880 ctaatggtac atgcttcaca ttgaaaccat cctcctgaca caaacataat actttgccct 209940 ccactgtccc ccaaagtggc agtaggattt ctctaagtaa ttttctttac ttatatgagt 210000 gcaggatagg gggtgttttg ggccaaaagg tagctttttg gacatgaaaa cggaaatgcc 210060 tgttcccatt tagggctgca ggtcttcagg cttgagggtg gggcctttgc ccaggaacta 210120 ccctcttcta cccagtgttt ccctgtctcc tgtccatatc accagtattc acagtctcaa 210180 ggagtcttga gaaagtgtgc ccaaggccgt cagattcagt ttggttctgt atgtcacagg 210240 gtctaagaag cgtaaacatt gtgtcttgtt gaaatacagc ctctaggtat ggaggatgtg 210300 ttgaacaact tcctaccagt catttggcat atgttgattt cctgtcttca tgatacgtaa 210360 gacgactagc taattatcat tcatatgtgg taagtcacat agatactgac ttcccctatc 210420 tttccagctt tttcttatca aaagtcacct gctctctgtc ccaggaacga ctggctaaag 210480 taacctatat cagtgtctgt aacagtgggc acctatcata gtgcacatgc ttgaacatat 210540 cattgccttt tatcatcacg agcctcacat ccagatgtga cagactcaag tgctcacatc 210600 acctcactct gtcactgtat acattgttac cgtgtcacaa atatttaaca gtctgctgtg 210660 tactcagtct ttagctgtgt gccctgaggg agacagagta agatactgcc ttgacatcaa 210720 ggagctcaca ttctccctaa agagataatt tcacatgaaa agttagtgtt taatatgaaa 210780 agttagtgtt taacatgaaa tgtcctgaga atatacaatt ataatttaca cgtttcctgt 210840 gtgtactttt ctaagttctc agactcaaaa caaagcccca tggaagaaaa aatgaaataa 210900 aaaccctgtc aggacaaatc ctagccagaa ctgaccaaac ataaaaaata aatgccactg 210960 ccctctccaa gctaccttta ctttatactt gggtccaaga agcccaaaca ttgtgcctca 211020 ttgaaatata acctctaggt atggaggatg tgttgaacaa cttcctacca gtcagtgcag 211080 tgcagtgacc atttagcagc atctccctcc tctctccttc caccccctgc cccatctctc 211140 cttccttgca tctatcttcc cctgccaaca ataattttct tatgttctaa gtaaatatct 211200 ttagtgctct ccctactacc taaacattaa acttcaaacc tttcccaaga ccctgaacac 211260 ccaccccagc ttgtaagttc aggctactta ccattcccca ggcacactgt attttccctc 211320 ctctggtaca ctgctcatgt catcgaatct atcttcctcc caccccatcc tggattctgt 211380 aaatataaat cagtcctgcc cacctttaag tttcagtcaa aacctgatac tcatggcctg 211440 aagcaatccc tcccttctcc atgctggtct gagagaggtc atgatatttc agtagctctg 211500 gagagacaca tatggtcaaa ccagaccagc taaaattaac ccatgctatg cacaacctaa 211560 agaatcacct cttgctgtaa cctctttctt ctcttgctca ccaaaaactg tctgtcacat 211620 ttgctaagta agcccttagg gctttgctgt gctggcaaaa ggtcttaatc catgtgaatg 211680 tgcatttttg tgttagtgag cacatgctaa catgccttcc acagattagt ttcttaagaa 211740 acattttctg ggggaaaaaa gacctgtttt tggttagtaa ccccaaaagg acctttcagt 211800 tcacatacgt ggtagcagca tactccactt atgcaaaggt cagcccaggg taaatatggg 211860 caaaaacaca gacttaggat aagaagaatg ttaagggagt ttacagttta aagagatatc 211920 caaacaactt ttttatattt taaagaagta atgctataat tttactacaa agaaaacttc 211980 tttatatttc tggggagaag aataggaaga gttacaatct cctagagaaa agcaaaacat 212040 ttttagtatt cccaaataag acaggcacct caactagggt gctgtggttg cacgttcttt 212100 gtagtttttc aagaatttta tttctctgtc atgattattt attggcagaa gatttgttgg 212160 gccaaacatg taagactttc ttaaacacat atagagaaaa aaattagatg attgcacatc 212220 tttctgaggg agatttttcc cctattttta aaagtcattg cttttcactg aatttgtctt 212280 gtattcctat aaaagtgtaa attttgtgat tgatagcatt tttacctcaa aatgaaatga 212340 atatccaact ggagcaagtt ttattgactg cttattggag cataaattag tctaagtttt 212400 catgaaaata ggcatttgaa catgagtatt aatggctgag atcagaggca agttttgaaa 212460 ggattccaaa atattatcat attagatagg caagcaaatg aattgcttga atgctagaag 212520 ttcacaaaca ttcaaacaat tgtgagttac attaacttca ataaaaactt ttgcaggaca 212580 aaaatttaat atagtaaact tcatcttgct tgtccaggtc cgtatacatt cttagctgga 212640 ctcttgtcct agcttcctaa tttttcttcc tatctcctat ttttccctat tccaagccac 212700 catactctgt tcttgattaa ttcttcctgc ctacctctga ttcagtgatt catctgccca 212760 atcatctata gtagctccaa actcttttct aaattatgaa taaacttatc tccctggcat 212820 tcagaaaatt caacagcatt catcttacac acttttctag ccttatctcc cttttctctt 212880 atgtactcct atgtttatat tccctgcagt cttgcttcat tatatccatt tacaatgacc 212940 cttttaccag taatttcctc ttctttcctc tcagtctgaa acaatccttc atagattttg 213000 tcctgtgagc catatttcaa atacaacttt atccacaaag ctttgcccag ttcccacaag 213060 aggattctgc ttttgcttta gaattgtagc ctttttttcc tctctcgcaa ggagagagag 213120 cgtagcaccg cagtttaagt actcagcctc tggagtaagc tttagtttaa gacccagttc 213180 tactgcttac ttcctgtatg atcttctcta aattttatga tctctttgtc tttttttttt 213240 catctctaaa ataaagatgc taatagtacc tacctcataa gatggttgtg agaattataa 213300 gtgttgatat atttaaagta gttagaatag tatctggccc tacagtaagc ttacgtggta 213360 tttattgtat tctcttatgg ctcttatttt attccaatgt gtattaaatt gaaccgtatg 213420 aaattgccca tgtcaactct atattggacc ctaaaatcat tatgtctttt ggttcaacca 213480 aatgtagtgc tttttgcacc cccccttaat aaattgaact atctctaaag atagggacaa 213540 tatcttacac atcattatat cctacagtac ctgctacata cttgacatat gctgagtatt 213600 tcacggatgg ttattgaatt ttgcacacac acacacacac acacactgca aaaaataaac 213660 agaagccaag ccctccccag tatcttaagt actctttggc taccagggag tttactccat 213720 gctgttcagc agtcatttat gaaaggagag tgataaagat atagaggagg agaattttat 213780 cttgtctatt gctgagtata aatactatgc ctttccgaaa agccttccac agaacctttc 213840 cttcaggtca gggacctagt gtcatgggtc ggtcttggat aacgttgcag gacatatcag 213900 ttcaactgcc aagggaatca taaatagtcc tactcctgcc tgcggcccac cactgcctct 213960 ctgctttcat tcttttttat cagatatttt caacatcaag aacttattag ctgataattt 214020 aactaaatta agtataacat aagggaaatg tgtcctggca gagatggcat cttagagtga 214080 atgcacagtc tttattggtt accaaaaaca aaaaaaaaaa aacttgagct ttggacaagc 214140 agtagagagc agatttgata ctgggttctg acatggaagc tgacattaaa ttattgacag 214200 tctacttgtt tataaactat tcaataaaca atttagtaag taaacataga ttcttgcaat 214260 cccttttaag gaaacagtgt ttatgttggc tctctcttgt acccaaccta gtgctcagcc 214320 tttcctgact cacataagca ctaatctcca gataacacca agcaccctag ggttattatt 214380 tatccccctt ccttgttctc tgaaataaga gaaaggcagg ttaaattatg cactttatgt 214440 aagaagaaat ggaggtacag agaaaacagc ttaagtctct taacagccca agagagtgaa 214500 gaagatattg ccaatgcaat gagttgtatc tgtccctagg taagtaaaat attaattaaa 214560 gcatacaact atattaataa ttaaaacaac agtctttact tatatggact ttgcagtgac 214620 ttttttccag cctgaaatac tcagataatg actgccatta gtttcacacg ttagtgcttt 214680 attatatact gctttgtttt cacacaaaat cgttgagagg taagaatttt ttgaaagaaa 214740 tatttggtct taactttttt atcccccttc aacttcaagc aattttctga gcaatgataa 214800 gtggtaagta gatatttacc acttagttta caagagacct gtttctctct gtgcattgac 214860 ttaggcacta ttaatgaaac ctttggaatg caggtccctt ctggttgtaa acatatactg 214920 aggtcttcta tttcttttgg aactcaaaca ataagaaaat agttagaaat ctgtttgtgg 214980 gcataggtct ctaaaagcct taatcttaga agtgagtaaa aaaaatttta ggccagacgc 215040 ggtggctcat gcctgtaatc ccagcacttt gggaggccga ggtgggcgga tcacgaggtc 215100 aggagatgga gaccatcatg gctaacacag tgaaatcccg tctctactaa aaatacaaaa 215160 aattagccgg gcgtggtggc gggcgcctgt agtcccagct acttgggagg ctgaggcagg 215220 agaatggcgt gaacccggga ggcggagctt gcagtgagcc gagatctcac cactggactc 215280 cagcctgggc gacagagcga gaccccgttt caaaaaaaaa aaaaaaaaaa aaaaattaga 215340 gcctaagaag gatgattaag catcttactt aaattttcag tatgcctatg tacactctat 215400 atactgactt ctagcatggt ttctttgcca aagcataaca cacatttttt aaagggataa 215460 ttcaagacaa acattctttc accctgggtg accccaatgg gtggtgaaca ctttttagta 215520 actcttgaaa gttaaagcat ccaacagttg gttgtgacct ttttggttgt gacctttgag 215580 ttcttctagc ttgtagccca ctgatttgct gcttaattcc acagcttcaa aaccaactct 215640 aatcactgct cccgagagag ccctagcttc tgcacacatg agtctctcac caggaaagga 215700 tacctgaagt ccagaaaagc cctttgttca cactggctcc tcctagtggg gaacagtttt 215760 tttaaataat gtacatttat gcactgggaa aatatcttga atttattatt taggtgtaac 215820 cagactttaa tacaacttaa cctacacact gagaaagcag acatttacaa aaagatttat 215880 ggctttgaca aagcgttcaa atgtagttac cattaaatag tagttcaagt aattgtgtgt 215940 ctcatggcaa atacatgcaa tataaggtaa tatatattta agccaaaaat aacaagaggt 216000 gatcatttgc taaacaaaga acttattact taggaaaaaa tgttacacaa ctttcaaagg 216060 acttttgaaa atatagtatg atttatagga aatttatttg catataattc acaatatctg 216120 gtacaaggta agctacctct gtgttttttt tctttaggtc aacaaatatt taaaccaagg 216180 gttggcaaac aggccctcag accagatgct tgtttttgta aataaagttt tattggacca 216240 cacccatgcc tgtttgtttc agattgtgtt tactttaggg ctacagtggc agagtggagt 216300 agctaagaca cagagcatag gtccacaaac ctaaaatatt tactctctgg ccctctaaaa 216360 aaaagtatgc caaaccattc taaacagcaa agcaattaat tctttttttt caactcttat 216420 tttagattta gggggtacac gtgcaggttt gttacatggg tcaattgcat gtctctgagg 216480 tttggtgtac aaataatccc cttacccagg tattgagcat attacttgat gtttttcaac 216540 tcacaccccg ctcccaatct tcaccactct agtagtcccc tgtgtctact gttgccatct 216600 ttatacccat gtttatccag tgtttagctc ctgcttataa gtaagaacat atggtatttc 216660 gttttctgtt cctgcgttaa ttcacttatg atgatgactt ccacatacat ccatgttgct 216720 gcaaaggaca tgattttgtt cttttttatg gctgcatagc ttttcatggt atacgtgtac 216780 cacattttct ttatccagtc caccatcaat gcgcatctag gttgatttta tgtttttgct 216840 gttatgaata gtcctgtgat gaatatatga gtgcgtgtgt cctttttgta gaatgattta 216900 tttttctttg ggtatctacc cagttatggg attgctaggt tgaatggtag ttctgtttta 216960 atttccttga gaaatctcca cactgttttc cacagtggct gaactaattt acattcccac 217020 cagcagctat aatatggttg tttgtttgtt tgtttgtttg agacggagtc tcgctttgtc 217080 gcctgggctg gagtgcagtg gtgcgatttc ggctcactgc actctccgcc tcccaggttc 217140 aagcaatttg cctgcctcag cctcctgagt agctgggatt acagtcgtgc accaccacgc 217200 ccggcaaatt ttttttattt ttagtagaga cgggatttca ccgtgttggt caggctggtc 217260 tcgaactcct gacctcgtga tctgcccccc tcagcatccc aaatactata ctgccccctc 217320 agtataatat agtattttaa ggaactaatc atcaagtttg tactggttac cctcttttag 217380 tctcctgtta tcttcaattt cataattggc attaatgaca atacagtgtt cactttataa 217440 atttgcttca tagtaaactc ttctgaaata aattacagtc atgcatcact taacagtggg 217500 gataggttct aagaaatgca taattaggta atttcatcat tgtgtaaaca tgaagtgtac 217560 tcacacaaac ctggatggta cagtctgctg cacaccagcc tttatgatat agtctattgt 217620 tcctaggcta caaatctata cagcatgtta ctgtactgaa tattctcagc aattgtaaca 217680 caatggtaag tatttatgta tctaaacata gaaaatgtac agtaaacata tagtattgta 217740 atcgtatggg acgactatca tatatgcagt ctgtcgttga ccaaaacatc attatacagc 217800 acaagactat agttgaaaat tttaaattac atatgtgggt tgcactgtat ttctgtttgc 217860 agcattgata tatacattta atggtttgta tgtttgtgct tgcattcata aatattaaac 217920 tgttacaggg agcatatttt cttgtgtaaa aaaataaata atttttattt ctaatgacat 217980 ataaaattat tatggttatg tttaaagagg cttgaagagg tattatggtt atgtttgaag 218040 aggcaacgga aacgtcacct ttgtcattga ccaaaacatc attgtgtggc tcacgactgt 218100 aatagtgtaa agtaaggatt caatgtatcg gctaatcaat gtggacatat cattcagtat 218160 tattaaagat actccatcca atgaagactg aacacctgta aatgcttggt gatggatgga 218220 aagggcaatt atttgcagct ggactgtctg agacgtgtca tcattattgc ataatattta 218280 tttaatgaag gatcaatgca ccatacagct ccagtttgag aacacacttg acattgtagt 218340 ttgtagatct tttataaact aactgctatc actgaatttt tgctgaagaa taaagacaaa 218400 agattctctc tttaggaaat tgtgcacttt aaagactcat aaacctgaaa cctcacagaa 218460 tcataataga tgtattttca gagacaattt ctgagtcctt gacatattct caaatgtcat 218520 tcatgtcttc actgccgcag gttatctttt tatttttatc tgtcatggaa aagcagcctt 218580 ttttcttttt ttatctccta ctatgcctta ataaatagaa tttaaaaccc cgaatttgaa 218640 ttattgtgaa agccaatatt tgtagcaaat ccatctatgc tctgtgttgt cagcacatat 218700 ggttttgtgt acctgctacc atgaaactct gccagggtta tcctcagaga aatggagaga 218760 cacctgatgc catccttact ctgacagaag tttttctttc tgtgaattcc aaaaactttt 218820 gaagttatgc atctcttgca ttgaacttca gtggcttgtg tacacatggt atcttccttt 218880 ctagattgta agttctttga gggcagggac tgaacctttc tcatctttat atgctctgct 218940 cctccaccct tggtttagcc agggccttac aaaaagtaga agcttaaata atgtttatta 219000 ggtgaatatc atactaagtt ccagaaatta cctgagagca attgaagaag ggaagtgtgg 219060 agggagaggt gttagcatag atttcatagt gtttgagttt ggcagtttgg catccttttc 219120 ctcaacacta atactgacac agataagtaa cctaactgcc ttctcaaatc tgagagcagt 219180 agatgcattt tctcttttgg gacttttcta tctcatgtgg gaaaagcaaa caagaaggtc 219240 ctgcaaaagt cttgtgggta tttattctta tcagtggttg tggcaaactc tcttactggt 219300 ttcaattggt cccacaggct atgtgatgag gactttgggg tttggggagc tgggaaccat 219360 gagttgtctc ttaagtatga cctaacatac tgctaatacc ccacaagctt caatttatcc 219420 atctcgaaat ggagatacta acatctatct caaagggtca ttgtgaggag cgagtaggaa 219480 catagaaaag ttcctagcac aaagtagata tggaagatat ggaataaggt gttaggtatt 219540 ttattatttt tactgctgct gctgctgtta ctactactgc tattattatt actactcctg 219600 gaagagtagg acttgcctgg gacactgacc ctacttaccc cttcacctca ttcaccaaaa 219660 cttatctcct atataaattc atgtatattt ttctggaagg ataagaaaaa tccttcatct 219720 aggtagcgta ttttgtattt gaatagttta tgtttcaaat cccagagaag gcctatacag 219780 ccaaatttgg aaaaaaaata aatttaaaaa taaatattca gtgtttcata tataataaaa 219840 tacctaacat cttattccat atcatatatg tgtgtgtgtg tgtgtatctt ttaattgcca 219900 tgtatttcta ccaaaaaata caaaacttaa ttttgcgtcc tgaaagaccc tcgtttgaga 219960 atccctgctt ttatgttctg ctttagtcca ggcaacagat agcttaggtt gtcactttac 220020 aactggagca gcaggtaggg ctgagaggct cgccatactc caaattacca gtgccagtcc 220080 catggcacca agacaggaaa ggcaggcact caaacagaaa ggtagtgcaa ttaattgctt 220140 caaattcttt actcagggct gcccttagtc atgatcaaat aaaatgtaca cattgtttgg 220200 cacttggtaa aatgttgttt cctttccttc ctccttcccc tgatagactc tccttaggta 220260 caaaaaagat gaggctgtac acagagctaa aagtgtacac ctttgaaaaa ggtgtctttt 220320 tcaaagagca ccttcacccc ttactggact aaactcaatc caaagctctt ttctctaagc 220380 tttataacac ttactgcctg gatgagtcat ttgtcaataa atacagaatg tttgtatagg 220440 tggggttctt gtatatatgt acgagcccct agagtctcta acttaaaatt tatttttgct 220500 ttagaagttc aggaataagg aggctttgat gatcaatttt aacaaccgca atatataata 220560 cagtaactaa tggttaggtg tccaggctag cccagggcag cctgtgtgat tcatgctgct 220620 ggtgaaccat ggctggctgg gcgaactaga tctggaattc tgtggtgcct aagggaggga 220680 agggaatatt tcccacacta tctcatcctg ccctcactat cgctaccccc aatctctctc 220740 tacattctac cccacctact ttgctttttc tgtgaaagac cagctggggc aaatattttg 220800 gattaagtaa aatttgtctt gggtaacttc cctaaaattt agtttttaat tgaataatct 220860 tggttaatcc atgagtaaat aagcttgtag agtatagtca gcctcactgt gagaagctga 220920 caaaccagaa aaccagagga atatacacca attccttcct gtcctgcaaa cctctgcttc 220980 ttgaggtttt taaagagtgg gtgcctaatt gattagtcat tagttattga caggaccaaa 221040 gagatatgcc tggctcctct tggaaaaacc aaaagactga gagggaaaag tacaccaaaa 221100 agatacctaa ggaggcagac tgctataaag aaaataatta ggagaagaaa tcatatgttt 221160 tcagatgaaa agaatctgag gatgaaaaaa gcagcctttt caggccgatg atggaaagat 221220 agaaactaaa ttcagaagga tcagaagacg attagaaggg caagaagtca tagaagacca 221280 agatttccca aattaccaaa agaaatcaag cccagtcttg ttcaggctgc agaatgagaa 221340 cgcccttcta gtaagatccg tacaatgaat ttcacaaatg ttgatttctt tctgtcctct 221400 ttgagcccat aatcacctcc ttctacttgc acaaccttga ccatcaccac tacctataac 221460 taataaccag ttcttatgtt cccctcaagg cataacacaa aaatattttc tttatgatta 221520 ctttctctac aaaaaagagg gagagagaga gaaacaagtc aggggacttc gttggtgagt 221580 gtagaccaca gcaagaacct aaaatcctag tgggttgtta gtatagacag gctgaaacca 221640 ctatcctgaa gtggtggttc taggtaggta tgcccatcag aatcatctgt ggataagtat 221700 tttcagtaaa tacacatgca ggacctctac ctcaaatgta ctgaattgaa cttcattgct 221760 ggagcttagg catttcatat ttgtttccta agctgctata acaaattacc acaaacttgg 221820 tggcttaata agagaaatgt attctgtcac agttctggag gccagaagtc caaagtcaag 221880 gtatgaccag gattggttcc ttctggaggc tctgaggaaa ttctgttcca tgcctctctc 221940 ctagattttg gtgactgcca gcaatctttg gtgttctttg atttgcagaa acatcattcc 222000 aatctctggt tctgtcttca cttgaccttc cctatgtctg cgattggtct cctttctgtc 222060 tcttttaagg acacctatca ctgaatgtag agcctatcct aatgcacaag gagctcaatt 222120 ataccttaat tatatctgta aagacccttt ttccaactaa agtcatattc acaggtacca 222180 aggtttagga cttgggcata tctttggagg atacagttca acccattaca catatgcatt 222240 gaagggaaaa attcacgcca caactgatta tcctataaag aatgttggct taacttaacg 222300 catttaacgc accatttctc cagcacttag gaaatgctag gagatgcaaa gctgaagcta 222360 aataggcttc tttattgcag aacctctcag aggctctcat ctgtttgtgt gcattataaa 222420 tgtccaagag aaagaaaaga atcacaacat ttcctggaaa tacttgacca gggaacttct 222480 tttcaaggga ttacctgtta actacctcaa tggacactaa tgactaaagg aatacatgct 222540 gctggtgatc atggcacttc caaactatgc tcaatggtgt gggcatgagt ctaccacagt 222600 gtctaaacac taagattgtt aatgtctaca cgacctctcc ctggatatga gcacacatcc 222660 ttcatcaaat atccacagtg gtttccctag aggatttgca tatgtgcatg gatttttaga 222720 tgtctagtct ctactcttgt cttcagccat ttttgtagag agaaattggc aaaatattag 222780 catgaatgga agggaaaggt ggccaagata atacattatg cctttttttt tttccctgaa 222840 aacagcccag aatatctgaa aagggagaag tgacttaatc atttctattc ccacaattct 222900 ggtcctacaa aattgatatc agtatatgat tcatccagag aagttcacag tggtattttt 222960 ttaaaaaaaa cttttagagg ttaccagggc atctcactat tttaaaattt aatacctcaa 223020 gggaaataag caactacctt gaatttttgc atgaattgca tttgagaata actgaatagt 223080 tggtggaata aagttgtttt tttaaaagta ggcatattct agttaataaa tataaaagaa 223140 atggtaggat tagaaaaatc actacattac aaactctaat gacataatag atttaagcaa 223200 gatgatcagt gaatgataaa atatttaggt atgctgtctt ctaggtgaat caagctgaca 223260 ataccttgga cccacgttaa tcttaccaca tgatattata tgtctcctga tacttaaaat 223320 aaatatcaaa taaatcttga taattgttga aaattgttga tgaacatata gttcacagca 223380 ccacccatga tgtattcttt ccatgagaat tgatctgaat caaagtaagc ctctaggtct 223440 aactgccagt gtgtaggaaa taccagggat agagaaacat ttttaaagtc tttaagattg 223500 cagtaagctg aaagaaattg tctggtttct gcaataacag caacaaagtt atgtaataag 223560 aagagagagg gagaatcacg gatttataca aacttaagag acactgtgtg aatctagttt 223620 gtatcctgat caaacaaatt aactgtcaaa agatgtcttt tgaaacatga tgggaaattt 223680 gagcataaac taagtattct acgatattca ggaatcatta ccaatttgtt agatatgatg 223740 ttggtatgtt tttttaaatg agaaagtttt tagcttttag agatacatac ctagatagtt 223800 atgggtgaaa gcatatcatt aaaaaaaaga tagtggaagt acacaaaaca ggattgctat 223860 atgttgataa ttgttgaacc ttggtgatga acatatagga attaattaaa ccatattttc 223920 tatttttatg tttattttgc aaattccaaa ataaaaatag aataatccct catgaacaga 223980 tggtctcaaa tttcatcctc aagtaaacac aattcacatt ctcaggggaa cccatgagaa 224040 tattatgaag tatatgtcta tctcatttca ttatatatgg aatcctacca ttccttttgt 224100 ctttattact agtggccaga gttctatctt gaaaggtggg aaatgtcctt atatgaacag 224160 attagtttag agaattattg tgagaaaacc agaaaatatt tgagttctag ctaactggat 224220 attgaatgag ttgtgctgaa gtatgtggtc ataaagggtt gataatgaaa tacttgcttt 224280 ccagtggcaa ggaaaaataa atgtcttaga atttacaagg tcattcttga aatcaatcaa 224340 cgtgggctga agatctcatt gcttctgtta tctggcacga tggtatttgt ttgtgcacag 224400 ctctgttgat gtgagctatc aaatatttct tagagctgaa atcatctaat agcaaacatt 224460 gctatgtccc aatggagatt ccaagactct ttggccatgg aacatttaca ttctatcccc 224520 tttcatcact cctgaacaaa caaaaacaaa aaaaggaaag ataaccaata ggctttttat 224580 ttaattgaaa accaaagaga gagagaggaa agaaccagtt agttgccatt ttctaaatgc 224640 aggcttttgt ttgtttctgc cttctaattc tttgctcttg aagctatagc tttcaagctt 224700 gtgtatacag gcccagagag aacatttgaa atgtggccac cctacccatg tccatgccac 224760 tcttcctgcc tttctctctg cctacttctg ctccaccatc ccaggtcagg ggcttggagg 224820 ctgacagcat tacaagtaat atagtcgttc aagctcatat aaacaagatg aaatccaaat 224880 aataaccaaa atgtatttta tttcaaggac tggactactc agttccctca gtttcgctga 224940 ccgatttcta ggagccctag gctcagctct tggttgtctc agaactgagg agagtactca 225000 tttgcaccat atgcatctgc ttgttagcct gtgctaccaa aattgattca ttacttggcc 225060 ttctctgaaa agaaaaatga aaacaaaaat gcactcttaa aaataattat taaaatacaa 225120 ccaggaggta tgtgcctaga catggctcac cttctaccaa atcatacttt atgattttcc 225180 acaatattat cttctattcc tcctgcccct aaggttccat ggagcagagc aagttgaaga 225240 atgttaaggt tttactaaac ttttagaaca gaggctttgg ggaagcaaga gagaggtaca 225300 ctgaaaatga agtgtctgtc tctgcttcta ttaatgtcat aggactagaa gttgacctca 225360 tagctgatta caaatgaacc ctgcaaattg aaccccagca catgcctctc attatccatt 225420 cttctctttg caggatgggg tccatgctca catatcaaga aaatggtggg tttcagtctg 225480 gctcactggg tgaggttttg gcatgaaaac taatacgggt tagtgtacat cacccataat 225540 aaaagtaaaa gctttttttt ttatttaccc aggtaaataa gcaaaaggca gatctaaaat 225600 acattagagt taagttccat ggggacagaa atgtctgctt tgtttgttgt tatacaattg 225660 acacctagaa tggtggctgg accatagtga ctacaaataa aatatttctt aagggaatga 225720 atggttctgc aggatagatg ttctctgcat ttggataagt gatgatacta tagactcaga 225780 gcctagatag aaaatattgt cccactttca gttctgcaaa ctgacttgag gtgcttggtg 225840 acgtcctgca gcaagcaaac caaatgaagg catctctgag accccatagt caccaccagc 225900 atgctagcct cccattacct tgcccaccct agattttcaa attgggaatc actgtggtac 225960 cagactggga atcgtgactt gcatactttc tcatattggg gcttgggatt ttgagatctt 226020 atttcctttt ttggcttctt gagatctgaa attgttgttc agagaaggat attaagacaa 226080 tgactcttcc attaccatgc atttctgtta ccaacagagg aggtaagtga atcacttaaa 226140 atgatacaat tccatccact tcagtacacc ataaacatat ccttagcttt gactataatt 226200 atagtatgtg ggtgatgccg ctgagaaaat ggtataatta taacattatg gttgagaatt 226260 gtctgagtag aaaacactga gctgtactgt gcaaagttta aggcggaatt gtgggtccct 226320 tttcaatatg aataaaattg attagccaat tgcaactgag agctttgtgc aatgatatta 226380 ataatataaa aatcggccgg gcgttgtggc tcacacctgt aatcccagca ctttgggagg 226440 ccgaggcggg tggatcacga gatcaggaaa tcgagaccat cctggctaac acagtgaaac 226500 cccttctcta ataaaaataa aaaaatatag ctgggcgtgg tggcaggtgc ctgtagtccc 226560 agctactctg gaggctgagg caggaaaatg gcatgaaccc gggaggcaga gcttgcagtg 226620 agctgagatc ctgccactgc actccagcct gggcgacaga gcaagactgc gtctccaaaa 226680 aaaaaaaaaa aagtcaaggg ccaaagtaac aatgtaggaa aaatttgatg actttaattt 226740 catttacttc taggagtctt acatgcaagc ctaatgcaga gtagagaagc tcaccaactt 226800 gaaggaagca tgaatgaaat tacaaggaaa tctagcttag aaaaattaac cctgtagctt 226860 ggtttttcca ctctttgctc ttggcaaaag gatcttacgt atgtatacca aatgtctatt 226920 tgaaaatttt gtttctctga atatagcttt cttttctctt taacacactg gtccagtggt 226980 tctagatttt atgctcccat aaattaagta agacagcatt ctatatcatg actgaggtgt 227040 taatgacatt atgcagttgt cacattttga aatataaact taaatgcgag cttttcactg 227100 tgtgtaaagt ttctctgtat ttttttaaaa aatttttaaa gaccagagat tttcagcaac 227160 aagaaacata aagaagtaaa aagagcgtag aaaccctgcc ctagaggacc tgctccacca 227220 cttaaaagcc atgtacctct tgaagcctgt ttcctttatt tccaacacag gaatttttat 227280 atttacaccc taaccatcac atgggtcaca tgtgataaca atgtgcaagt ttcttacaag 227340 tgttctagga atctgtaagt cttagagttc tgaggtttat tcccaaagga caggaaattg 227400 tgggttacac caaacagtta aacagggtgg cagggaatcc ctgtcacgta cccaggcctt 227460 tgggttattt tctagggtga ggggacatgg ccagtagtac aaagagcatg tgaacgcatg 227520 gatgtgggtg tgtgaggtca tgagtgggtg tgtatgttta tgtacaacac atgtattgga 227580 ggataaaagg gaaaataatt tgtcttcctg acttcttctc tattcctggc ttttcttaga 227640 ttgttattcc tctctaaaca aagcttcaaa acagaaaccc ctccccttct ttattatatc 227700 ggaaatctgg gaattcagtt atccttgtct tatcctactc cctgttctgt tctaaatata 227760 taataacaat aagtaatagt actactacta gtactagtag tagtagtagt agtagtggtg 227820 gtggtagtaa tggtagtaat agtaagagga tgaaaagatg gaggaggtga attggaaata 227880 gggaggtttc ctgtagctga ctgacagttt atatagcaac cgcctgcaga tttaggtttt 227940 ttctgactgc gcttatttta tagcaacctc aacaagctgt gacaacctgc aatatcttta 228000 gcccttaaga tactgtctct taaacctgac caatatttct tatttctcaa agagtaatga 228060 tagtcttttc tgtctgataa gttcaaaagg cacaactgat tttcctaaca ttttcctcaa 228120 atgaagggag tatttgaaaa atggaactca aatgaggagc cacctcagaa gcctaactgg 228180 agcattcaga ctgcatcaga cagacttggc ttcagttctg acactgatac ttactagctg 228240 tgggattttt ggacaagctt ctcatctgta aacaagtata aatactacct actttataag 228300 ctcgtatgaa aattcccaca aagtttgatg ttagtttcct ttctttttgt gctcagctct 228360 aaaaatatgc agtgtagtga gtcactaata tttcattaac ataagggaaa actatatacc 228420 caacccaaaa gctgagattc ttcagaacat tttttaaaga ggttctaatt aggaatttta 228480 taaatggaat acagagtact ttttaaataa taataacaat gattaattta agttactaaa 228540 caaaatacct taatgaattt gagaaaaata aactgaagat aaatattaat tattaaaaga 228600 gaaaattatt aaagtaataa catgcaagtc acttgatact tgcaaagtaa cacagaatta 228660 gacataaagc cacatttaag aggcagcaaa gccaaaatgg ctggccccct ttaaaaggct 228720 cttggcaaca gacatatgga aaactgtcat ctcttccctg ggcctttctt cctactctgg 228780 ataagcagca tccttcacac aaaagaacat ccaggataac taagaaagag atgaaatgat 228840 ttatcggaac tagttaaaat aattaaatct taaaagcatg ttctcctggg catagagtgg 228900 ggtgatttct gcaaacattt tgaaaataaa gtacccctaa aacaaggatt tggtttaact 228960 gctagaaaac aaggtgacag gttgagaaaa ctgaaaattt tcttaaaatc ttgtttactt 229020 gaatggtgag ccagccaccc agggaagaaa ccagagctct ttcctttaag aaatatagac 229080 ttcagttgga agaaaaaatt agtaggtttt aaccttcaac cttctagtga agtgagaata 229140 ttgattgagc acctattatt agaataaatt tatcttaagt gacccaggga agggtcgtgg 229200 gtgacgggaa ctgtcaagaa agaaaaaaaa tatggctgtg gatcttaagt acttaaaatc 229260 tactgagggc tcttgtctcc attttcctta gaccgtgatg ttgctcaaag tcacataaga 229320 gggcacataa atttactgaa tagtattaca gaaagcagca gtgacactga aatgcttgca 229380 ttatattcac tatcccagtc atctgcagtt gcctgaggga tttgcaagca aggacaggaa 229440 aatgctagta ccaaccagtt ctagataaag aatttatttg ctccaaaaac tttcactgta 229500 ttaaattaaa ttagattggc tggaattaaa aggtaataag gcccattttc ttatgtaggt 229560 catcaattaa tttaactcta aagataattc caaaagaaga ggtttaaaaa ttgtttgagt 229620 agtagtaaca tcattggaat ttatgtaaaa cttcccaatg tactcacttt tacagataac 229680 atatatatat atatatatat atatgtatgt ctatgactgc tggcataatg atcaaaatga 229740 tcagttttat tactttgtaa tcacatcagg cggcactgat ggttgaaata aaatgtgtta 229800 gatgagtgaa tgcaaagata acatatagca aatgaaagtc tttgtctatg aagcacatga 229860 ttgttataat tgttgctgcc cttttgggat cctgaaccag attccccaaa taagtaggta 229920 acacagaatt tgtcttgagc actttttcaa gcattgtaat ccatgcattg aagtaggctt 229980 tatcagccta cagctataaa ctccaaggtg attttaaagt ctgaaggttt ataggtcttc 230040 attaggataa gctgggctta ccatataaat ctatgaggac tttgctagaa aaatagtgga 230100 attgttgaat agggaaaaga gataatggta acgggatttg cctgatgtct tcatcctaga 230160 aaaaaagatt tctgcttggg cattaaggac cccagtgatg attctgggag actttcagga 230220 atgctgacaa ggctggagct actcaggatt tgatgccaaa gaagccacac tgcacatgtg 230280 ttcctctaag gtgtacttgg ttctcatctg agaggcaaag gctctacttc tttttaattg 230340 tttggtccta agttaccttc aaactccacc taaccacatc tctaatcctg tgtatagcct 230400 ttccaacatc ttgtaaattc caaggggttg ggggaacctt taggttccaa ggctgagcta 230460 agttataaat gaataccctg tgcagtgttg agaatgaaac agaagctttg gtgcgtggta 230520 gcccactgtg agtggggttt caaaggagca gtccaggggc cctacatgaa taggcatata 230580 tgggccaaga gacaggcttc tctcagccat accatagtat actggaacaa tgagaaatgg 230640 gagaggacat acttcttaaa gtgacacact gacctgtttt cattctctcc tctctctgct 230700 tctccatttc cacttattgc ccctattgca tctgtccagt aactgtttct ttaacagttt 230760 tccaaactga cattattaat ccagaagatg gatggtggtt ttttaattaa aagagaaagc 230820 tgattttatt tggtgagact tctgctatca tcttcagtgt tatatcccaa tatgagtact 230880 ttttttaatg ttctactaaa tccaatagta tattcacctc actctcgagt taaactcttg 230940 gctttaaaaa aattagccag aaaaacttct taagaaaaaa tacagtattt taaattctat 231000 aaatgaacta tatcttaaaa tatttggggg cataattcaa ttgtatccat tttactttaa 231060 gatcatgcaa aaagggaaag gtatagatgc tattttattg atatgctgct ccatggattt 231120 caaattcaac atcataagcc aagatttgtg ggaccagagg aatgttcaaa agtataatct 231180 gatacattat ctgctgcagg aattaagtaa aatattgcat acatctcact tcctatacca 231240 aatagagaga atgaaagtac tagattttgt attacagata gtttagacaa ctatagggaa 231300 ttctgaactt tcaaactttt atatcctaaa ctcaagattt gggccttgaa aaataaaact 231360 gataaaactg ctacagtgta gatttttaaa attacattca tgtggtgaag ttgacacttt 231420 ctgttggtat ggctagaagt cagatagatg cttaatttga aagaccatgt ttttatttct 231480 tctctttttc ttaccctatg atttcattga cctgaagtgg cttttagtgc cattcaattc 231540 acacagaagc caaaattggt tactgtgtta agaagaaacc aagatgtttt atttagttta 231600 tgaaacacta gcaaaattac tatttgatgc aaaactgtga ggaagttttg tagtcattga 231660 aaggagcaag aatatagact gcttgcagtt ccagtgtcga gacattcatt atcagattta 231720 ccacttgaaa atattatcaa gatagtattt atattgtgtt taccaggtaa actaagcact 231780 ttagttctga gcactttaca tattttaaat cattaatagt gctgtaacaa gcctctgagg 231840 taggtactgt tatccctctt taacagataa agagactgag gcacaaggaa gagaagtgac 231900 ttgctgaaat cacacacagc tgaatgtgga ccctgattca aatccacaca tcctgactca 231960 agcatccttg ctctgtacta ctgtgctaca gtgcctcttt acatcctcct gatgtagaaa 232020 tcttcttcta gaataatgag aagcagtgtg aactttgaag taggacttcc tgggcatggt 232080 gctttccatc tctgggccaa agttttctca tctttacaaa aggattacga tcaaccccca 232140 tctcatactg tggttaggag aattgagcaa gaccatatac taaaagatgt cagaacaggg 232200 cctgacagat catagtgccc aataaacatt ggctcttgtt atcatcataa atatgttaaa 232260 atgagcttta gtatgtggat aatagtagca gaatttcctg aatgagacat gttaaacatt 232320 tattaagcag gcactttttg gagtttatct tataataatt cagtaaggtt actcttgtca 232380 tccctatttc actgaatttg aggaatctca ggctgcaaga taacgtatta gttttctaga 232440 atcaaataag caaggattca aactcaggat atattgaccc caaaacctca gatctttctg 232500 ccatccctat cttgttctaa accccaggtt tgctcatccg ggccctagtc attgatcaaa 232560 aagcaccaat acaaatcaga gtagagaaag tcatattgag cttgtgaggt tgtattatgg 232620 gcatggtaac aaatgtaatt cagctgtatt ggcacagtgc ataacaacca cacttaattt 232680 ctgtcctaag acctgtctga gcccataaat aaagttacat taataattac ggaatggtaa 232740 gggaccactc agaaaatctt ggttgatata ggaagtggca tctgtggctt ctaattgaga 232800 gatattgctt cttgaatcag tgctagacca ttgctctagg gggatattaa gccttctctg 232860 tccatggaag atgtgaaatt caacagctga cctgactgct tgtcgctgtt gatgatccta 232920 taaaatttcc tctaagatac gaactctgtg ttctagtcca aatcaagtga atatttcctg 232980 ttggttgacc tacaacttca agggtatgag gtcataagtt taaaaagatt ccttttctcc 233040 ccagtgttgt aagagttatt ttagttctat caaatgctcc cagtgagtac tgcatatttc 233100 ctttttgcca gatacattag ctattcactc ttttttccta tctcttctat gcttttattt 233160 tttccctcat ctgtttaacc aatggtaccc tgaattttag aaccagacag gtagtaggac 233220 aaggcaggtg aaaatgcaca ggttgtaaat ttcagaatgc acattcaaat tccatcgttg 233280 tctcttacta actgaatgaa tgtaggtaag atgctttacc tctcagagtc ttacttaccc 233340 catctataaa atgagaataa tacaaactgt cttctgtggt tttcttgagc attaaacgtc 233400 tctatttatg gaacatagtt tcacatagta actgattctg taccaatgcc ctgcccccca 233460 tgtaggcaaa tgcatgtccc gaaagaccca aaacaagttg tccctctttt caagatgaag 233520 atttgtaatc tctccttaaa cttatccagt tctggtgttt aatttccttt ataagccaga 233580 agttgtttta cgtctcacca aatcttataa catgaatatt acactgtctt ccaaatgtga 233640 gcctctaatt accttaggcc aatagcagag cctctgatct tgtcttttct ccttttccgc 233700 ttaccagaca gcacattctg cctgagagtt gagacccaaa aagatataaa tcaactaggg 233760 ggcaaaaatg gagtttccta agcttgtccc agagtttgac tcagtagcct gaggtggagt 233820 tcaggggctt gatgttaaaa acaagctacc ccagtggttt tgctgcaggt ggaccagact 233880 cccaagacca cattttgcaa gcactggcat ttaggaagag cacgtaccta ctctagcaga 233940 gtttatgcag actatgattg cagcctagtt tgtgcagact attgattgca gccacttggc 234000 aaggctctat aagaaaaagc gagccaacat gtaagtaaat tatcatggcc ttgaaactcc 234060 tcatctgaaa gggtttcctc tcatcccctc atccccttgt gtctgcccct gaatgccaga 234120 ctatcttctc cagccccaag tcaacctctc atttttaagc cattcctcat tctcctatat 234180 agtccaaaat agcgaataca tttttaggaa ttctcttgct ttatggacgt tcatccaaaa 234240 atatttcatt atgagaataa gtgcttagct tatcctgtag tgtctttctg ctctaatatt 234300 tgggcccttc ctttccacat agttgcattt tctttgacgg gcagatgctg ctcctttaat 234360 atttttcaca cctttgtgct tctaacagag caattatttc aggatgaggg cacttggaga 234420 gctgtaagag gataaggagc ccagggctct gccttggatt tgtgtaccta aatgttacct 234480 aattagataa acctgaggaa gatgtggaag caaagtagaa tggaacagaa agtgtttgaa 234540 taataagaat ttggacattg ctgctccgtg gtgacattgg cagactctaa gcctcttgcc 234600 tcattttatt cattcatgta tgacggggtt atgctcagtc ataagtcact aaaatttgta 234660 ttctacatcc cattagtaaa gtaatttttg aacacatgat acatatgttt acatatttgt 234720 aagttatata tatgtacaag gttctaatat attctgttca ttgtcaaaca taaaatatat 234780 ataaatttgg tttaatataa aatataaaat tggcattagt agacactgtc taccgaaatg 234840 agacactgtc tcatttctga aaaaagcaca atgtatacta agttaaaggt tcattcttaa 234900 cagcagtagg agtagatctt tatttcaaat agtctttggg ataatttcct attttggaag 234960 acagcttatc agatttggtt agagttgatg aaagcttatt ctagggttaa gaaaagtatt 235020 agcccagcca ttttcttatt gttgatttgg gcttgcataa ttagttttac cttcagtatg 235080 aagtttcttt acatgaatct ttttaactca cttatttgtt atacaattat tagttaaatc 235140 aattttaaat cagtataatc tatccacaaa atcagtcata cagaacctgc aaaaaacatg 235200 ttctaacatg ttacatgaag aggtaactaa agatactaca aacaacccct ctgaacggta 235260 acactcccac tcttcctgca aaattcctct catagcaaat gcaacatgtg actcagacac 235320 aggctgactg aaggctttat gcaactctta catgctcaat attagaaaac tttcatttgt 235380 ttcctatttt atataaacaa cacatataaa taaacatttt agtatcttct cattacccag 235440 tggattgtct tgcatggtcc attttgaaga cagtaaactg tagcctctat ttttatttaa 235500 tttcaaatac ctgtttgcca atattcacag ccagctcttg ttaatgttct tttctgtcct 235560 gtgaatcctg atgtcgtatc ttgcaacatc acctctaaag cctatctttg cactcctgtc 235620 catcccccat tctctattat tatgctgcct ctgatggcca gagaaaaaaa tcttgaaaat 235680 atatattgta ttgccctacc tggcgaggaa tcagcagtta tacaattcaa agttgcagca 235740 attcaccaca ttgtttagca ccctactatg tgtaaggagg aagcttgatt taaaaaatat 235800 atacaatcat gccttcttca agaatgtttt ggagcatgca agagcttaat gctcatggac 235860 atttacttta ttccagcaaa tttagaccca atctctgtgt agtttcattt tgttttccat 235920 ttcctgatta actgactata tatctagcta cttatttgct gccatctagt gtaataaagt 235980 atgttgatta tacaaggaat tttgagccca ttatgtagtt gaatatcagt actcaaaatg 236040 attctttttt tctggtttct tataagttta caaaatgcct agtcagggac ctttcttatc 236100 actgtaaccc tgaacatggt cttaatcttg tgtcatagaa tctagggctc aggatcaacc 236160 ttcgttcatt ttctataaat gtgacatttg gaaactgggt aggggcttag cagttggtgg 236220 atatgaagta aatatataag agtaatcatt aagagatcat ctcagtttag tgaccatgat 236280 tttttcctca tggaggcagc aaaacacagc atggattctt accagtagtg tgaccatggg 236340 caatttattt ctctcttgga ggcatcattt tcttcatatc taaaatgaaa tggtaggtcc 236400 aggtgactgt taaggtctct tctagctcta agagtctgtg tctacatata aatgattttc 236460 tctgccaaag tagtgttttt agagtccttt ttaatgccag aaatgaatac ggcttctcta 236520 gttcttctaa gtggccatct atcctttggt gatggttaga agtaagcaga gatcctggct 236580 agaaagagag agaggaaaat gtggaccatg attttattcc ttttattctt gagagttgtc 236640 caatgggata ttgtccacta gtggataagt agatacttgc caatatgcac ctgacctctt 236700 ctcttcactc ataatgggaa tttagaagta taatacctgt tataatcaac ttcctaatct 236760 ctatcccttt tttgtcactc tatttcctac tgtaacttct ctatgaagta ctataagtct 236820 acagtaacat actggtgttt ccctttcctt atgaagtttt atatagctac tccagtatat 236880 cctaaaatgt tcctttttct tgcttttata gtggagtctt gcttgttggc caggctggcc 236940 tcaaactcct gagctcaagt gatcctccca cctaatagta gctgggtatt cttctgagta 237000 ggtggtccta aaatgtttta ttttcagctt atttcatagg tataagtctt attttcccaa 237060 ccaggctgaa aacttttcag aatcaggact tgtctttagt ttctcatttt ttatgagggg 237120 atgtggcatt attgcttagg gaattcagat atttctgata ataaagatgc ttttctgttt 237180 gttcatataa attagggtaa aagaggaagt acaaaactat ctcaaatcaa gtacaggact 237240 cttaattatt actagctatc taacagctca tagaaaccga taagtttctg aacctaatgc 237300 caaaaaaaag caaccttacc ataaaaagaa aatccaaata aaactgaaag aggcagtggg 237360 cagtgctacc tatgggaaga aaactttgaa gtgggaaaaa tctggattca catcccagct 237420 ttgctactta ttacctttgt gttttggcta aaaattatct aactttcctg aagttaagtt 237480 tccttctctg taaaatgagg gttataataa tatatacagc atactccaca gaagagttgt 237540 gaagatggaa tgagaaagca aatggcaaaa acttagcaca aagtaggagc tcaatcaatc 237600 atggttaaaa agaactttta tccattgtta tttttgctta tatacagtaa gaattatcca 237660 atgcaaatgt aatcagagca tctgcaattg agctttataa agtgaattat aattctcata 237720 ccatagtggt tctcatcaag ggtgattttt ttccccccag gggacatttg gcaatgtcta 237780 gagacatttt acttgtcaca ctggaaaaga gggggtgcta ctggcatcta gtaggtagag 237840 agtaggaatg atgataagca ttctctaatg cacaggacag cattccacag caacaaatga 237900 tctgatccaa aataccaata gtgtggaagt tgagaaaccc taccataaag cctagggagt 237960 ccattacttc tgacctaaat ttgttttata tttaagagtg gatgtggatt aaaagtagct 238020 tccattttgg taggttatga agagagttgt ctaatctgtg ctttagattc taattttgag 238080 gcatattttt aggctaaggc attgcaatat ataaggcttt ctaagtttca gacattttct 238140 tggaggtcaa caaatgaagg cttggggatc tattaaccca ctagagtagt gtaataatgg 238200 tggtggttgt ttattgaaga ctaaccaagt gccaagtact ctataataat ctgatttatt 238260 tttcagcaac tgtataagca ggtattttgc tctcatttta cacaggggaa aactggagct 238320 tagagaactt atgtaacatt actagcaagt tgcacagctg ggattcaaac tgaaatccag 238380 ctagcttcaa agactgtgtt ctttctgctg ctgcatacta cccctaccta ccaaggctct 238440 gagattagaa agcaggatgg gtgtgtttta aaggaaataa ggtaggaaag ttttcaaata 238500 ttagaaactc tgcacaagaa gattaggtca agtttcccac tgaggggccc ttgagtatct 238560 atgaactcga tgaaaactct gagcttctca ggaaggtaga ccaaagggaa aggattcatc 238620 aaaatggatg ttagcactat gccatgtgta ttactccatc ctcacacggc caaaaggaca 238680 tacctgagac tgggtaattt gtaaggaaaa agaggtttaa aaaagttctc ttcgatggcc 238740 aaataggaac agctccggtc tacagctccc agcgtgagcg acacagaaga cgggtgattt 238800 ctgcatttcc atctgagcta ctgcattcat ctcactaggg agtgccagac agtgggcccg 238860 ggacagtggg tgcagcacac tttgcaggag ccgaagcagg gtgaggcatt gcctcactca 238920 ggaagcgcaa ggggacaggg agttcccttt ccgagtcaaa gaaaggggtg acagatggca 238980 cctggaaaat cgggtcactc ccaccctaat actgcgcttt tctgacgggc ttaaaaaacg 239040 gcgcaccagg agattatatc ccgcacctgg ctcggagggt cctacgccca cggagtctcg 239100 ctgattgcta gcacagcagt ctgagatcaa actgcaaggt ggcagcaagg ctgggggagg 239160 ggcgccaggc attgcccagg tttgcttagg taaacaaagc aggcgggaat ctcgaactgg 239220 gtggagccca caacagctca aggaggcctg cctgcctctg tagactccac ctctgggggc 239280 agggtacaga caaacaaaaa gacagcagta acctctgcag acttaaatgt ccctgtctga 239340 cagctttgaa gagagcagtg gttctcccag catgcagctg gagatctgag aacaggcaga 239400 ctgcctcctc aagtgggtcc ctgacccctg acccctgagc agcctaactg ggagacaccc 239460 ctcagtaggg gcagactgac acctcacacg gccaggtact cctctgagac aaaacttcca 239520 gaggaacgat caggcagcag cattcaaggt tcatgaaaat ccgctgttct gcagccaccg 239580 ctgctggtac ccaggaaaac agggtctgga gtggacctct agcaaactcc aacagacctg 239640 cagctgaggg tcctgtctgt tagaaggaaa actaacaaac agaaaggaca tccacaccaa 239700 aaacccatct gtacatcacc atcatcaaag accaaaagta gataaaacca caaagatggg 239760 gaaaaaacag agcagaaaaa ctggaaactc tgaaaagcag agcacctctc ctcctccaaa 239820 ggaacgcagt tcctcaccag caacggaaca aagctggacg gagaatgact ttgacgagct 239880 gagagaagac ttcagacgat caaattactc cgagctacag gaggaaattg aaaccaaagg 239940 caaagaagtt gaaaactctg aaaaaaattt agaagaatgt ataactagaa taaccaatac 240000 agagaagtgc ttaaaggagc tgatggagct gaaaaccaag gctcaagaac tacatgaaga 240060 atgcagaagc ctcaggagcc gatgcgatca gctggtagaa atggtatcag tgatggaata 240120 tgaaatgaat gaaatgaagt gagaagggaa gtttagagaa aaaagaataa aaagaaacaa 240180 agcctccaag aaatatggga ctatgtgaaa agaccaaatc tatgtctgat tggtgtacct 240240 gaaattgacg gggagaatgg aaccaagttg gaaaacactc tgcaggatat tatccaggag 240300 aacttcccca atctagcaag gcaggccaac attcagattc aggaaataca aagaacgcca 240360 caaagatatt cctcgagaag agcagctcca agacacataa ttgtcagatt caccaaagtt 240420 gaaacgaagg aaaaaatgtt cagggcagcc agagagaaag gtcgggttac ccagaaaggg 240480 aagcccatca gtctaacagc taatctcttg gcagaaactc tacaagccag aagagagtgg 240540 gggccaatat tcaacattct taaagaaaag aattttcaac ccagaatttc atatccagcc 240600 aaactaagct tcataagtga aggggaaata aaatacttta cagacaagca aatgctgaga 240660 gattttgtca ccaccaggcc tgccctacaa gagctcctga aggaagcact aaacatggaa 240720 aggaacaaca ggtaccagcc actgcaaaat catgccaaat tgtaaagacc atcaaggcta 240780 ggaagaaact gcatcaacta acgagtaaaa taaccagcta acatcataat gacaggatca 240840 aattcacaca taacaatatt aactttaaat gtaaatggac taaatgctcc aattaaaaga 240900 cacagactgg caaattggat aaagagtcaa gaaccatcag tgtgctgtat tcaggaaacc 240960 catctcacgt gcagagacac acacaggctc aaaacaaaag gatggaggaa gatctaccaa 241020 gcaaatggaa aacaaaaaaa gtcaggggtt gcaatcctcg tctctgataa aacagacttt 241080 aaaccaacaa agatcaaaag agacaaagaa ggccattaca taatggtaaa gggatcaatt 241140 caacaagaag agctaactat cctaaatata tatgcaccca atacaggagc atccagattc 241200 ataaagcaag tcctgagtga cctacaaaca gacttagact cccacacaat aataatggga 241260 gactttaaca gcccactgtc aacattagac agatcaacgg gacagaaagt taacaaggat 241320 acccaggaat tgaactcagc tctgcaccaa gcggacttaa tagacatcta cagaactctc 241380 catcacaaat caacagaata tacatttttt tcagcaccac accacaccta ttccaaaatt 241440 gaccacgtgg ttcgaagcaa agctctcctc agcaaatgga aaaaaacaga aattataaca 241500 aactgtctct cagaccacag tgcaatcaaa ctagaactca ggattaggaa acccactcaa 241560 aaccactcaa ctacatggaa actgaacaac ctggtcctga atgactactg ggtacataac 241620 aaaatgaagg cagaaataaa gatgttcttt gaaaccaaca agaacaaaga cacaacatac 241680 cagaatctct gggacgcatt caaagcagtg tgtagaggga aatttatagc actaaatgcc 241740 cacaagagaa agcaggaaag atccaaaatt gacaccctaa catcacaatt aaaagaacta 241800 gaaaagcaag agcaaacaca ttcaaaagct aggagaaggc aagaaataac taagatcaga 241860 gcagaactga aggaaataga gacacaaaaa acccttcaaa taattaatga atccaggagc 241920 tggtttttgg aaaggatcaa caaaattgat agaccactag caagactaat aaagaagaaa 241980 agagagtaga aaaataaaaa atgataaaga ggatatcacc actgatccca cagaaatgca 242040 aactaccatc agagaatact acaaacacct ctacacaaat aaactagaaa atctagaaga 242100 aatggataaa ttcctcaaca catacaccct cccaagacta aaccaggaag agttgaatct 242160 ctgaatagac caataacagg ctctgaaatt gtggctataa tcaatagctt accaaccaaa 242220 aagagtccag gcccagatgg attcacagcc gaattctacc agaggtacaa ggaggaactg 242280 gtaccattcc ttctgaaacc attccaatca atagaaaaag aaggaatcct ctctaactca 242340 ttttatgagg ccagcatcat cctgatacca aagcctggca gagacacaac caaaaaagag 242400 aattttaggc caatatcctt gatgaacatt gatgcaaaaa tcctcagtaa aatactagca 242460 aaccgaatcc agcagcacat caaaaagctt atccaccatg atcaagtggg cttcatccct 242520 gggatgcaag gctggttcaa tatttgcaaa tcaataaatg taatccagca tataaacaga 242580 accaaagaca aaaaccacat gattatctca atagatgcag aaaagttctt tgacaaaatt 242640 caacaacact tcatgctaaa aactctcaat aaattaggta ttgatgggac atatctcaaa 242700 ataataagag ctatatatga caaacccaca gccaatatca tactgaatgg gcaaaaactg 242760 gaagcattcc ctttgaaaac tggcacaaga cagggatgac ctctctcacc actcctattc 242820 aacatagtgt tggaagttct ggccagggca attacgcagg agaaggaaat aaagagtatt 242880 caattaggaa aagaggaagt caacttgtcc ctgtttgcag atgacatgat tgtatatcta 242940 gaaaacccca ttgtctcagc ccaaaatctc cttaagctga taaacaactt cagcaaagtc 243000 tcaggataca aaatcaatgt gcaaaaatca caagcattct tatacaccaa taacagacaa 243060 acagagccaa atcatgagtg aactcccatt cacaattgct tcaaagagaa taaaataact 243120 aggaatccaa cttacaaggg acatgaagga cctcttcaag gagaactaca aaccactgct 243180 caatgaaata aaagaggata caaagaaatg gaagaacatt ccatgctcat ggataggaag 243240 aatcaatatt gtgaaaatgg ccatactgtc caaggtaatt tatagattca atgccatccc 243300 catcaagcta ccaatgactt tcttcacaga attggaaaaa actaccttaa agttcatatg 243360 gaaccaaaaa agagcctgca tcgccaagtc aatcctaagc caaaagagca aagctggagg 243420 catcacacta cctgacttca aacaatacta caaggctaca gtaaccaaaa cagcatggta 243480 ctggtaccaa agcagagata tagatcaatg gaacagaaca gagccctcag aaataacact 243540 gcatgtctac aactatctga tctttgacaa acctgagaaa aacaagcaat gggaaaagga 243600 ttccctattt aataaatggt gctgggaaaa ctggctagcc atatgtagaa agctgaaact 243660 ggatcccttc cttacacctt atacaaaaat taattcaaga tggagtaaag acttaaatgt 243720 tagacctaaa accataaaaa ccctagaaga aaacctaggc attatcattc aggacatagg 243780 catgggcaag gacttcatgt ctaaaacacc aaaagcaatg gcaacaaaag caaaaattga 243840 caaatggggt ctaattaaac taaagagctt ctgcacagca aaagaaacta ccatcagagt 243900 gaacaggcag cctacaaaat gggagaaaat tttcgcaacc tactcatctg acaaagggat 243960 aatatccaga atctacaatg aactcaaaca aatctacagg aaaaaaacaa acaacaccat 244020 caaaaagtgg gcaaaggaca tgaacagaca cttctcaaaa gaagacattt atgcagccaa 244080 aaaacacatg aaaaaatgct caccatcact ggctatcaga gaaatgcaaa tcaaaaccac 244140 aatgagatac catctcacac cagttgttag aatggcgatc attaaaaagt caggaaacaa 244200 caggtgctgg ataggatgtg gagaaatagg aacactttta cactgttggt gggactgtaa 244260 actagttcaa ccattgtgga agtcagtgtg gcgattcctc agggatctag aactagaaat 244320 accatttgac ccagccatcc cattactggg tatataccca aatgactgta aatcatgctg 244380 ctataaagac acatgcacac tatgtttatt gcggcactat tcacaatagc aaagacttgg 244440 aaccaacccg aatgtccaac aatgatagac tggattaaga aaatgtggca catatacacc 244500 acggaatact atgcagccat aaaaatgatg agttcatgtc ctttgtaggg acatggatga 244560 aattggaaat catcattctg agtaaactat cgcaagaaca aaaaaccaaa caccgcatat 244620 tctcactcat aggtgggaat tgaacaatga gaacacatgg acacaggaag gggaacatca 244680 cactctgggg actgttgtgg gggtggagga gggggaaggg atagctttag gagatatacc 244740 taatgctaaa tgacgagtta atgggtgcag cacaccagca tgccacatgt atacacatgt 244800 gactaacctg cacattgtgc acatgtaccc tgaaacttaa agtataataa taataaaaga 244860 aaaaaaaaga aaaagaggtt taatggactc acagttccac atggctggtg aggcctcaca 244920 gtcatggtag agggtgaatg aggagcaaaa gcatgtcttg catggcggca gaaaagaaag 244980 catgtgcagg ggaactgccc tttataaaac catcagatct catgagactt attcactgtc 245040 atgagaacag cacaagaaaa acctgccccc atgattcaat taccttccac cagctccctc 245100 tcatgacaca tgcggattat gggaggtgca attcaagatg tgatttgtat ggggacacag 245160 ccaaaccata tcaccatgac atacaatttg ccgattcagc aacagttttc aggtcttcta 245220 tttttaagcc taatgcaata tattttatga attcttccta tttatgtttt tccttttaaa 245280 taagttctac tatcttaact atcactttca aatataatgc aagctacata tgccatttta 245340 aattttttag tagttacatt taaaaagagg gtgaaattaa ttttaacaaa gtaggttatt 245400 tatcccaata tatccaaact attatcattt tgacatgtag tgaagctaat aaaagcattc 245460 attgttaatg atctatctct tacattattt tttcctaata aatcttcaga atctgggtgt 245520 gcattttaac tttccagcac atctcaactg ggatgtgaaa ttttcagcaa ttaaagtgaa 245580 atatagccct atcaaaacta ttaatgttgc atttaggaaa aagatatttt tcactctttt 245640 tatttttaaa tttgagttta aattaattaa aatggaataa aatttaaaat tcaattctct 245700 gtcacactag ccacatttca agtgctcaat acctacgaaa gacccatggc taccatattg 245760 gacagcacag atctaagctc ttattgctca gaatgtggtc cccagagcag aatcaacagc 245820 atctgtgaac ttatcaaaag tgcagtattt cagttcacac ctactgaatc tgcattttaa 245880 cacaatcccc aggtgatgct tgttcacatg aaagttgtgt ctctctaaat cgcagatctt 245940 ttcaacaaag agcccagaaa aagcacatga atcaataact gtgaggaata aggaaacttg 246000 ccacaggaga atggtgccag ggttggcatt aatgatgtgc tctggtgaaa agtcgtaggt 246060 ttcccacaaa ggcaaccatg gctattctat tgtttgaact gacacagagc cattctagag 246120 cttggagttg gctctgctcc cagaatctac atcaaagaat ctaacactaa cttccatgac 246180 taccacaatt aaggcagctg cacaccccac cactatatat atttgaaatt gcaactttag 246240 aacccctgta acacagccgt gagcatgttt ctgctataca caagtggaat ttaaggtcga 246300 acctccctgg gagaccccag gaagatcacc cacaagagtg gcttttgttg tctgcctcac 246360 tgtcatcctc tgagagctaa cacagacaca gtcaacatcc tcttatatgg aggttggccc 246420 agatgcccct ggggattcaa tgtattctgc ttcacctcac taatccttat ttggtttgtt 246480 tttcacagaa ctcagtattt gatgggcctt tcaatatttt cctttaagga attcattgta 246540 ctaatataac atagaagctc attgttctaa taagtggtcc ccaatgttgg ctgcacatta 246600 gaatcacctg gggcattttg aaaaatacca atgcccaggc atcaccccaa tctaattaaa 246660 ttaaacctgt ggaaggtatt ttgttaaaga tccccaagtg attacaatgt gcagccagag 246720 ttgaaatcca ctggtccaat tagaaggagg ccttagctag cggtcaggtg cccaaggaaa 246780 ggcatctcaa gttttaatgc gcatacagat agcttgggat ttgttaaaat gcagattctg 246840 atccagtagg tatgggtgga aataaaccca tgtttgtgta cagatgtttc tcttgtggta 246900 tgtggttggt aatcatcctc agtatgtttc catttccggc aaactgggtt gagttgatga 246960 ccctattctt actcctccct gaaacctttg tctctccctc aggctcccag ttctcattaa 247020 tcactacttt ctgtgatatt ctgaagcaat tattatcttt aactgccttt tttcattagc 247080 tacttctcta tctgcttatg tacgtgagtt atttcctcta ctggattacg atcttcaagg 247140 tagatccaaa tatcatgtca tttttataat tctcactgca cctaaagagt gccttacaca 247200 caaatgccac ttgttgatta attgaaacag ggaatagctg atgtgatcat ctcaaaaaat 247260 atccaaaaga cttaaaaatg caagatattt ttctttgttg gacagaaaaa gaaagtttag 247320 ataggcaagg gggtaggaga tattgaggct ttcaattttt atttcactcg gtacatattt 247380 aaattttgaa gaattatttt gtaatttagt gattttaatt atttgttggg aatagggcac 247440 tattgacatt ttggactaga tcattctttg ttgtggctgt catcctgtgc attgtaatat 247500 gtttcacagc atccctggcc tcaacccact agatgccagt atcacccttt accccagtct 247560 tgagaaccaa aaatgtctcc agtcattgca aaatgtctcc tgggaaactc attcatggtt 247620 gagaaccctt agtttagaaa aatggaagtg tgacacagct gtcttaccgc actaatatag 247680 acctgaaaaa aataaaaaat taaaaacatg cacataagag aatgacaagc tatgttctga 247740 gcaatatgtg tatatataaa tattaatata aaaatgttct ctgttcctgc gttttggagg 247800 ccatgtgctt gtagaccata tttatctttg tatttgtcat cttggtcatt ctctttataa 247860 aaatagaggt atattgcatg ccaatgctcc tcagcttatg aggttacatc ccaataagcc 247920 tgttgtaaat ttaaaaaatc ataagttaga aatgtcaaaa cttgaaaatg catttaatac 247980 cctgataaac acatcataaa gttgaaaaat cctaagtcaa tccatcatga gtcaggaact 248040 atttgtatat gaaacatttt taaaatctga acatagactt aggaatttta atatgtagtg 248100 gtagtaattc caccaagcaa gagaatacat agagcaaaaa tcattaagaa acagtgactg 248160 agatgattct cattctcagg aaactggtcc agccccttta cataaaatat tctgttcagt 248220 gtgctgtgat ccttggactg aatatactgt tttagcaagc agagttgtta agctaaagcc 248280 tgcacatcaa caggtgttca atgtctgctg aataaatgaa gaatgaatga atattaactg 248340 cacctctaaa ccctaaaatt aaaaagcttt aatgtgctca tcacaaaaga ccctattttg 248400 ttgcatttga aatttcaagc ttcaaaaatg aaattacatg caaaagtata ttatcatcaa 248460 tgagaataaa tggcctcaac aaaattacaa gatagaaaac aaagtttcat ttgtcagttg 248520 gtttcttctg gcaatagaag gctcccctta gacttcatta gcttcagata tttcagtgac 248580 agaaatttaa tgttggcaaa gcattgctat actttcaggc ttggattgga atgccccaca 248640 tttacttttt cctaccattc ctggctaaaa acttgaatgt gagaaccaga cacaaggctc 248700 tagtggtagc aagcagaatg tctcctaagc tccaagggga aaaaatgata taagtcagtg 248760 gttcccaaat taaccatcaa atgctaccca ttaaaatcac tggggaactt ttaaaaatta 248820 aatgcccaac taacaacaaa ctgtatgaaa aagaaattta gaaaacaatc ctatttttaa 248880 aagcagcaaa aaagtaaaat acttaggagt aaatttaacc aaggaaggga aatatctgtt 248940 tactgaaaac tatgaaatgt tgatgaaaga aattgaagat ggtaaaaata aatgaaaaga 249000 taaatatgta tggattggaa gaattaatat tgttaagaga tctatactac ccaaagcaat 249060 ctatagattc aatgcaatcc tatcaaaatt ccaaagtcat tctttatagc agtagaaaaa 249120 aatcataaaa ttcatatgga accacaaaag actctgaata gccaaagcaa tcttgaccaa 249180 aaagagcaat gctggaagca tcacattatc agatttcaaa atatattaca aagctacaat 249240 attcaaaata gcatgctact ggcattaaaa cagatctatc aactactgaa acagaatagt 249300 gagcccagaa ataaacccac acatctatga tcaattgatt ttcaacaaag ataccaagaa 249360 cacacaatgg ggaaagacag tgtcttcaat aaatggtgct gagaaaactg gaaatccaca 249420 tgctgaagaa tgaaattaga tccttatctc atcccttata caagaatcaa ctcaaaatag 249480 attaaagact taaacataag ccctgaaact ataaaactaa tgcagaaaat atagggggaa 249540 atctacatga tattaatcta ggcagaagtt tcatggatat gacctcaaaa gcacagacaa 249600 caaaagcaaa aatagacaaa tggcattgca tcagactaaa aaacttctgt acagcagatg 249660 aagcaacaaa tagagtgaag agacaaccta cagattagga gaaaatattt gcaaatcata 249720 tattagataa ggggttaata ttccaaaagg tacaaggaaa tcaaactact caataacaag 249780 aaagccaatt accctattaa aatataggga tagcattggg agatacacct aatgctagat 249840 gacgagttag tgggtgcagt gcaccagcat ggcacatgta tacatatgta actaacctgc 249900 acaaggtgca catgtaccct aaaacttaaa gtataataat aatttttttt aaaaaaaagc 249960 aaaaattaaa aaaaaaaaaa aaatatatat atatatatag gcaacaaact taaatagaca 250020 tttctcaaaa gaagcaagta tcaccctgat ttaaaacctg gcaaagacac aatgagaaaa 250080 caaactacag gccaacatct ctgatgaaca tagacacaaa aatccttgac aaaatactag 250140 caaactgaat acagcagcac atcaaaaagt taatttgcca tgataaacta gtgtgttagg 250200 gtgttctagc atgctattaa aaaataccca agactgagta atttataaag aacaaaggct 250260 taatttgttc atggttctgc agcctgtaca agcatggtgc cagcacctgg ccagcttctg 250320 gggaagcctc atgaaatttt tattcatggc agaaggtgaa acaggaacag gcacatcaca 250380 caggggaagc aggagtaaga gagagtgtga gggaggtgcc acacacttaa acaatcaggt 250440 ctcacaagta ctcactcact actgcaagga cagcaccaag ccataagggc ccacccccat 250500 gattcaaaca cctcccacca agacccacct ccaacattgg gcattatatg tcaacatgag 250560 atttgaacag atacaaatat tcaaactata tcaagtaggc ttccttcttg ggattcaagg 250620 ttggttcaac atacacagat caataaatct gactcaccac ataaacagaa ttataaacaa 250680 aaaccacatg atttcaatag gtgtgggaaa agcttttgat aaaatccaac ctcccttcat 250740 gttaaaaaaa aaaaaaaaaa ccttaagaaa ctaggcggcc gggcgcggtg gctcacacct 250800 gtaatcccag cactttggga ggccgaggtg ggcggatcac gaggtcagga gatcgagacc 250860 atcccggcta aaacggtgaa acccagtctc tactaaaaat acaaaaaatt agccgggcgt 250920 aggggcgggc gcctgtagtc ccagctactt gggaggctga ggcaggagaa tggcgtgaac 250980 ccgggaggcg gagcttgcag tgagccgaga tcccgccact gcactccagc ctgggcgaca 251040 gagcaagact ccgtctcaaa aaaaaaaaaa aaaagaaact aggcattgaa ggaatatttc 251100 tcaaaatagt aagagccatc tgtgacaaac ccacaacaac ataataataa atgggcaaaa 251160 actggaagcg ttccccttga agacaagaaa aggatgcctt ttctcacctg ttgtattcat 251220 gacagtactt gaagtgctag ccagagcaat caggtaaaag aaagaaataa aagacatcaa 251280 aatagaaaaa gaagaaatca aactacctct ctttactgac tatataattc tatgcctaga 251340 aaaacctaaa ggctccacca aaaaagctct tggaactgat aaacaacttc agtaaagttt 251400 ctggatacaa aatcaatgtg caaaaatcag tagcatttct atacagcaat agtgttcaca 251460 ttgagagcca aaccaagaat gtaatcccat ttacagtagc cacaaaagaa ataaagtaca 251520 actagggata catctaacca aggagatgaa agatctcata atgctgcaca agtacagcca 251580 tttaatcttc aacaaagatg acaaaattag caatggggaa aggactctct agtcagtaaa 251640 tggtactggg ataaatgtaa atgtcagtaa atggctagtc agtaagtgat actgactagc 251700 tatatgtaga agaatgaaac tggaccccta cctttcacca tatacaaaaa ttaactcagg 251760 atggattaat tattcaaatg taatatctca aactataaga atgtaatatt caaatatatc 251820 tcaaatgata tacaaactat aagatatata ttatatctca agctatatac aaactataag 251880 aatgtaatat tcaaatgtaa tatctcaaac tataagaatc ctataagaaa acctaggaaa 251940 caccattctg gacatcagcc ttggaaaaga atttatgact gagttctcaa aagcaatttc 252000 aacaaaaaca aaaactgaca agtttttctg tgtagaagct cttagtttaa gaaaaagaaa 252060 ccagcaacag agtaaacagc ctacagaatg ggtgaaaatc ttcacaaact gtgcttccaa 252120 ccaagatcta atatctggcg tctgttagga acttaaacaa ttgagcaaac aaaaaacaac 252180 cccatttaaa aatgggcaag cagcatgaac agacagttct caaaagaagg catataaaca 252240 gctaacaaac atgaaaaaat gtctcacatc actaatcatc agagaaatgc aaatcaaaac 252300 cacaataata tgctatatca caccagtcag aatagctatt atcaaaaagt caaaaacaac 252360 agacgctggc aaggctgcag aaaaaaaagt gaacgctcat acacggttgc tgggaatgta 252420 agttagttca gccactgtga aaagcagttt ggagatttct caaagaactt gaaacagagt 252480 taccattcaa cccagcaatc ccactgggta tatatccaaa agaaagtaca ttgtttcttt 252540 tggatattgt tctacccaaa agacacatac actcacatgt tcattacaac actgttcgca 252600 atagcaaaga catggaatca acctaggtgc ccaacaaagg tggattggat taaaaaatgt 252660 ggtacatgtc caccatggga tactacacag caataaaaaa gaatgaaatc atgtcctttg 252720 cagcaacatg gatgcagctg gaggccatta tactaagtga ggtaatacag gaacagaaaa 252780 ccaaatactg catgttttta cttataagtg ggagctaaac attgggtaaa catggatata 252840 aaggtggcaa caatagaaac tggggactaa cagagtaggg aggtagggag cagagagagg 252900 actaaaaaac tattaggtac tatgctcatt ccctgggtga tgggatcaat cataccccaa 252960 acctcagcat cgtgtgatat acccaggtaa caaacctgca catttgttcc ctgaatctaa 253020 aataaaagtt gaaattacaa tttttaaaag gatagaaact agtcatcagc gtgtttttta 253080 attttccagg tgactctaac attcaataat tattttaaat aattatttct gtctgtagac 253140 cttctgccag ctactaagtt tcaggaattt tgatggtctc attaaagaga acctgacaac 253200 cccacttaca agtgcttcag ctaagtttca tttataatat tttcatattg ccaaggatcc 253260 agtagtgtct tttttacagt gagttacaaa ttcctgtttt tgtgacagtg acaggccaaa 253320 attaatgagc tgtgattttt aaactgaaaa agtgactgtc caatagaggc taaaaagaaa 253380 actaaaatta tattttgtca attttagtgt taagtgtgat tttttgcttt gtatgtttta 253440 gatagttttt ttattgagat aaaacccaaa tagcataaaa tccacctttt taatctcaaa 253500 gtggtttttg gtatattcac aatgttgtgc aacaatcact actatctaac tctagaacat 253560 tttcattact tcctcatgga accctgtacc cattagtagt cactcccagt ttcccattca 253620 cctcatttcc tggcaaccac taatctactt ttctgtctct ctgtatgtga ctattcttaa 253680 catttcatgt aaatcagata ctataatatg tggcctttta tgtctgactt ctatcacata 253740 gcaacatatt ttcaaggtca ttcgtgttgt agcatgtatc agtattttat tcctttttaa 253800 gacaatactt tattatagga ttataccaca tcttttttat ccactcatca gttgatggac 253860 ctttgagttg tttctacttt tctgttattt taaataatgc tgttatgagc attcttgcac 253920 atgtttttgt gtgatcatat gtgtttgctt ctctgggcat atacctagga gcagaattgc 253980 agggtcatat ggtaactctg tatttaacat tttgaggaac ccccaaattg ctttccccag 254040 tagctatacc attttacatt ctgaacagaa gtgtgtgagg gtttctatta cttcacatcc 254100 tcttgctttc tattttaatt atttaattat ttaatttaat tatctaagat gccttttacc 254160 ctaaccaacc agaaaataaa cttgactgaa tttagtgcta attgtttttg catagtcatt 254220 cagtataatt gtctttgaca tctcaaaaca ctgcttatgc agaatacact tttttaaaac 254280 agtgaaatca tagcaattct atttcctaag tcagttcttc ttcagggtag taagttatag 254340 gtctttgagg tcatgttcct gtttccatct tccaaaaggc aacattatta aaatcttgtt 254400 gctgtatctg ccttggcata tccccctctc tatccagaga aaagatcact gacagaatag 254460 tgtccccacc tttctatctt agaggtctca ttacgagtca gtatgctttt aaaagaatta 254520 atggataaag agctagacat caagaagaag agagaaaatt ttaaataaga cagaggagtg 254580 tatgatcact ctttctaaga tgattaaatg aaataatttg aaaggcaata aactaactgc 254640 accaagtaaa tcttgtgaaa gcgaaaggaa agaggagaag gaagatttga gtgctgaaaa 254700 ccaggataaa ttgtattcaa ccaccagcat taagggaagt tatacaatac attttatgaa 254760 gaaagtgttc catgaaaata aaacaacaaa aagaaagttt ggtgaaggtt taaatgataa 254820 atgccaatag tagtatatgt gcaattatct actgacactg ctatacaaat gagctatcta 254880 tataggctgt gaccacataa cctcacctgc caaaccacag tactataaat aaatactttt 254940 cccagacact acagagctca gttgacttga gattcatctt atggtaactg gaaatgtaga 255000 ctgtgccttt atttgggtca atcctacaat tttctttaat gtaccagcaa ttcattattt 255060 aaagtttact agagtttaat ttaaaattat aaaaaaggaa gaaattggct gggtatggtg 255120 gctcacgcct gtaatcccag cactttggga ggccaaggcg ggaagatcat gaggtcagga 255180 gatcgagacc ctcctggcca aaatggtgaa acccagtctc tactaaaaat acaaaaatta 255240 cctgggcatg gtggcacacg cctgtagtcc cagctactca ggaggctgag gcaggagaat 255300 cgcttgaacc tgggaggcgg aggttgcagt gagccaagat ctcaccactg cactccaact 255360 tggtgacaga gcgagactcc atataaaaaa aaaaggaaga aattaatagt tcaggtgaga 255420 acttgtgaat ttttattctc aactctaagc tagtaagtgc ttaaatagaa gactttacaa 255480 cgagctgtac cttcttaatt ctacagagaa tcatgaggaa aatcaaatat aaatgtgaat 255540 ttcttatgtt cagtattgtc caaaaagaaa atattttatt aaattttttg tcagttgcca 255600 tcattattta aagccttcct gccagtagcc tatactattt ttggaatgga gtgtttgcag 255660 tttcataacc acttgataac accataggtt aaaaaaaaag tctaccagtc tttttcagat 255720 ggcctctttg acaatgcatt atttataggg aagttcagtt acttttaaca ataaagacaa 255780 gccaaaagaa attacagatc tcttttacca tattttgata tactagcagc atccactcag 255840 gacaggacct ttattaaaag ggggcttaag gtacttttaa ttggaggaat tactgaattc 255900 ctgaagctct tcaaacaaaa tagcacttgg gatatgacaa gagtactttg gagaaggctg 255960 cttggtccca aagcagagat tcaagaggag gactccagct agctgggtaa ggggttcctt 256020 cctctcaacc taagtgttta tgtaagcctg ctgggggcca ggaactgcgt aaaactcagt 256080 aagctcagta cttctcagca cagaatccag tcccaaggaa gcacccagca aaaatttagg 256140 ttgaattttc tttaaaataa aataaagaaa aaagtaaaat taaaaaaaaa atacaattca 256200 actactcagc ccattccatt ccgggtagtt ttggctcaga atgctggaag agttggatag 256260 gctattagtg agagaactca aaactcccca aactccactt cattactctt cctttatatt 256320 ttttctgaaa agagtattgc caatatatca ataaagcttt ttgctatgac ttcagagtgc 256380 ccaggtcact agggaaaagt atcaagtagc atcctgaatc cacaaatcct ttgagagcca 256440 gccacacagt atctgcgtga gtgtggtaat tctctaccct tacgagtgtc atcacagaat 256500 tgcagcattc tcttttcatt gtttctcagg aaaacataga caaaggctct gcttggattt 256560 ttttaattta acactaatat gtaataatat agcaacatct cctagttatc tagaactcag 256620 gctttgatag ctgtgactgt ctagaataca accacagaaa atcacctctg aacagtgagg 256680 gaaatagctg ccacagtatc accacctact ccaagcttga acctctcaac ccgcaaccaa 256740 cagactgcaa gtagttcagt acagctttga atgcagccca agacaaactc gtaaaccttc 256800 ttaaaacatt atgaaatttt tttgcaactt gttcatcagc tatcgttagt gttagtatat 256860 tttttgtgtt gctcaagaca agtctcttct tccagtgtag cccaggaaag ccaaaagatt 256920 ggacacctat actttggatg tttcatctag taccgatata cttataatta catgtttcaa 256980 ctagtactaa tgaacttata gttacaggat gaaatttcaa attagcaatg ttcatcattt 257040 gctcttccta ggtaacaaca gttaacaaat cataggttga caatcacaac tgattgtgag 257100 gatggaaata ataacaatga gcatttatat aatgcttact ctataccagg cacttttcta 257160 agaactttac atagattagc tcacttaatc tttacaataa ccctgtgaca taccattatt 257220 atccccattt tacaggtgag gaaactgaag aagttaagta atttgcccaa gattacagat 257280 tgtatgtgat tgaggtagga tttgaactca gcagtctggc accaaaatca gcactctcag 257340 cctctaccca gtattatcaa aagtaatttc ctggtagctt ctttcaattg tcatggcaac 257400 tctcaagata aagaattatt gtttttaata aataatgtca ttcccagaaa tgaattatgt 257460 gtgaatcata ctaagctgca gtgagagaat gaatatcacc atcacagtgg tgaatctact 257520 tagtgtaggg gtaaaaggcc agtctctccc agcagccctg cacataggta caccgtaatt 257580 cactaggata atccctgatc gccatgctgt cataaaaaaa cgttaaatga tgtttaacag 257640 gtttcattaa tgattcagag aatcttataa tatgtcttag gaaaaataat ttcaggagta 257700 actttcagtt agctagacaa tacagttctg ttgagcatct cataatctat gccagacaaa 257760 ggaaacattc ttgcctttct ttgagggaat tatagaccaa caattttatt aattttcaac 257820 tttcatcgag gcaagattag cttcatgaac aatgtttctc aaactgaaag tagtgacctg 257880 tattagtaaa tcaatttata gggttgcaag cagcatcatt tataaactga aatcagaatt 257940 cattgcaggc agtaattttg agacatttta ttttacatgt gcgtgtgtat atctatcata 258000 taaataagta tgtgagaaca ttttaaaaca tttaaaatat atttatatat ctaaagttta 258060 aatgtaaata tatatttata ttaataatat aattaatatg aattaataac atattaattc 258120 atattaactt atattaattt atattaacaa tatgtaaaca atatattaat tagtaatata 258180 ttatactaat attagtatgt attaatatat tattataata tattatatat taattaatat 258240 attatatatt gtatattata tattaattaa tatattatat attgtatatt atatattaat 258300 aacatactat tattaatatt ttaaatatat tttaatatac ttaaatttat acttaaaatt 258360 tacatataca tataaataat tttcctgaaa gtcactttca aaaactttga aagccaccag 258420 tgcagtggtt aagaatacaa attttgggct gggcatggtg gctcacacct gtaatcccaa 258480 cactttggga ggccgaggtg ggtggatccc gaggtcaaga gattgagacc atcctggcca 258540 acatggtgaa acattgtctc tactaaaaat ataaaaatta gctgggcacg gtggcacgca 258600 cctgtagtcc cagctatgca ggaggctgag gcaggagaat cacttgaacc caggaggtgg 258660 aggttgcagt gagccgagat catggcactg cattccagcc tggcgacaga gcgagactgc 258720 atctcaaaaa aaaaaaaaga atacaaattc tgaagcacag ctgttgagtt ggaatcatgg 258780 ctgtgccact taataaccaa gtgactttgg gccagttatt ttacttctct atgcctcagt 258840 gtcatctatt cagtagtgag aataatagta cctaactcat tctagttttg agaatgaaca 258900 ctttttatat tacatataaa atgtgtagga cagagacccc aaagaagccg tagttgctgt 258960 catattgtta ttctgttcct gcttaagaag gggacttgga aaaataatga tgttgaatgc 259020 agtaacttct ttcactcatg gaagaattac atattcacat cttctttgct catcaaacct 259080 ttgaagatca tgcatgtctc attctgtaac atcgccttaa ccaaatataa aggctaaata 259140 caaaggtgtt tttaaataac tgatacattt aggccagtca cacaaagatt ttacccaaag 259200 cctatgcagg catagtccaa gaagtagact tgttctactg caatcaccat ctcttgttta 259260 ttatttgtga aaggaacatt atggtttcac cacagttggc ctggccaacg tgcttatgca 259320 gtcctcagaa catatgaaag tgatttcggc tgacaataag tatttcctca ctttggctta 259380 tgttcaataa tagccattct ttatccagat cagggtgact gagcatgctg taaccattct 259440 tctcttctaa aactgaccct tgtttgactg catatgcaga ttgcttagca gaacccatat 259500 ccaccataac gggccaaaag tcatttgatc caatgtgctt ttcttttttt ttcttttttt 259560 tttaattcca tgaaatttta ttaagataaa ttaattataa acattgcaaa acactttttt 259620 ttttagacag agtctcacta tgtcacccag gctggggtgc agtgacacga tctcagctca 259680 ctgcaacttc cgactcccag gttcaagtga ttcttgtgcc tcagcctctc tgagtagctg 259740 ggattacagg tatgccccac cagacctggc taatttttgt atttttagta gagacggagt 259800 ttcactatgt tggacaggct ggcctcgaac tcctggcctc aggtaatcca cccgcctcag 259860 cctcccaaag tgctggaatt acaggtgtga gccactgctc ccagccccaa acatgatttt 259920 ttgattgaat gcttaatgtc tttctattat tattattttt ttttattata ctttgttctg 259980 gcatgcatgt gcacaacgtg cagatttgtt acataggcat acatgtgcca tgttggtttg 260040 ctgcacccat taaaaattaa ttcaagatgg attaaagact taaatgttag gcctaaaacc 260100 ataaaaaccc tagaagaaaa cctaggcaat accattcagg aaataggcat gggcaaagac 260160 ttcatgacta aaacaccaaa aacaatggca acaaaagcca aaattggcaa atgggatcta 260220 attaaactaa agagcttctg cacagcaaaa gaaactacca gcagagtgaa caggcaacct 260280 acagaatggg agaaaatttt tgcaatccgc ccatctgaca aagggctaat atccagaatc 260340 tacaaagaac ttcaataaat ttacaagaaa aaaaaaaaac catcaaaaag tgggcaaagg 260400 atataaacag acacttctca aaagaagaca tttatgcagc caacagacac atgaaaaaat 260460 gctcatcatc actggtcatc agagaaatgc aaatcaaaac cacaatgaga taccatttca 260520 caccagttag aatggcgatc gttaaaaagt caggaaacaa cagatgctgg agaggatgtg 260580 gagaaatagg aacgctttta cactgttggt gggagtgtaa attagttcaa ccattgtgga 260640 agacagtgtg gcaattcctc aaggatctag aactagaaat accatatgac ccagtgatcc 260700 cattactggg tatataccca aaggattata aatcatgcta ctataaatac acatgcggcc 260760 gggcgtggtg gctcatgcct gtaatcccag cactttggga ggctgaggca ggcagatcac 260820 aagttcagga gatcgagacc atcctggcta acatggtgaa accccatctc tactaaaaat 260880 acaaaaaatt aggcaggcgc agtggcgggc gcctgtagtc ccagctactc gggaggctga 260940 ggcaggagaa tggcatgaac ccgggaggcg gagcttgcag tgagccgaga tagcgccact 261000 gcagtccagc ctgggcaaaa gggcaagact ccgtctcaaa aaaaaaaaaa aaaaaaaaga 261060 catatgcaca cgtacgttta ctgcagcact attcacaata gcaaagactt ggaaccaacc 261120 caaatgtcca tcagtgatag actggataaa gaaagtgtgg cacatataca ccatggaata 261180 ctatgcagcc ataaaaaagg atgagttcac gtcctttgca gggacatgga tgaagctgga 261240 aaccatcatt ctcagcaaac gatcacaaga gcagaaaacc aaacaccaca tgtgtgttcc 261300 aacttaactc attgttctta gtgataattc acttaggggc aaagttaggc tctcttgtta 261360 attgcaacat tcctttcaga ggtgctataa atggatgttg aactatacta tttttagatt 261420 taatctttaa aaatcataag aaagcaagaa atattactag ttcagaaatg attttctgtt 261480 cctggctaat cagagaagac ctaagagtct atagtagtca tttgttgtct tcgtagtaaa 261540 agtaagattc taataggatt tttagacata gtgagaaagg tgttcatttt aagattatgg 261600 tagttcctct cagatttaga aagccttaag atgacactaa ggagttggac tttaggaatg 261660 ctgagtgtct tcagccacag cggcacaatg gtactagatg tgacaggatg tgattaagga 261720 gaaactaaac ggccaggcac aatatagttc ttcttgcctc caaaagagga gtcacccact 261780 ttctcacact cactgtgata cattccattt gctaagaaaa gtggcttgtg tcattcttga 261840 gcactacttt taagttctga tatattaaat tcatttactc tgtattaata gcattcaaat 261900 atttagtaaa gttaatatac ctctcacact ttttccaaag taacccacca gctgtgtcct 261960 gtgcttcaag ctatcttata agactgcaat caaagtgtca gccagggctg tggtctcatc 262020 tgaaggctgg atagggaaag attggttccc atgcttattt acattgttgt tggcaggatt 262080 cagttcctca aaggtttttt ttatttttat atattttttt ttgagatgga gtcttgctcc 262140 atcaccagac tggagtgcag tggcgcaatc ttggctcact gcaaactccg cttcccaggt 262200 tcaagcaatt ctcctgcctc agcctcccag gtagctggga ttacaggtgc atgccaccat 262260 gcccagctaa tttttctatt tttagtagag atgggatttc accatgttgg tcaggctggt 262320 ctcgatctcg tgacctcatg atccacctac ctcagcctcc caaagtgctg ggattacagg 262380 catgagccac cgcgcccagc cagttcctca agggttttta tactgagggc ctctacttct 262440 tgctgagtgt tggccagagg ccatgcttag ttctctgctg tatggttctc accacacagc 262500 aacgtacttc atcaaaacca gcaaaagggt gagtctgcta gttaaaaaga agtctcaatc 262560 ttttgtaacc taatcataga actgccatcc actccatgct gccatattct tctgattaga 262620 agcaagttac tcaagggaag gaaatacata aggctgtgaa tgagagaaga caggaatcat 262680 tggaggctac tttaggggct gtctgccaca gcacttaaca gcacataccc agccataaaa 262740 tttaaaaaag ccggaaagag agaaggaggg tgcagggtaa aataaagaaa agaggaaggt 262800 ggaagggaag aaaggaaggg aaagaaagac atttaaaaag acaagaacaa aacagctctg 262860 ctgcacaaca tctgtatcgg agttccatgt gcagacacac acgtcatcac atcagcacca 262920 cacccataaa tttcctattt cttatttaca atgagaaggt aataaggact ttctatgcat 262980 ctggagttaa aaggaaacaa taaatctaag aatactaagt ttaagtaatc aaaatgtgtt 263040 tcagattagt tattttttct ttttaagttt ttttttttgt ttcagctgac aaagtttttt 263100 atttctttct gtttcaagtt ttgaagttga gtttattatt cttgctatta tgtaacaggc 263160 atattttaca gagaatatag gaacctgatt gacatttgta tttggtgttc tattgttgtt 263220 tcaattcaaa tgccaaaatt atgtttttgt tgtgtacgtt attgttcata attatatatg 263280 cctcttaatt gtaaaagcga agctgtaaaa ttgtaaagta ctttgtgtct catctattcc 263340 aggcattcta ctaaggaaat caagaccaaa tggcttggga aggtcaacgt taaatagtgt 263400 cagagccaga actagagtac acatctctca atttctaatc tagtgcattt ccttttctta 263460 tttctgtgca aacgaacagt tagaatgtga aatagtctcc tcagatatac cagcattaaa 263520 acagttgtgg tttaaatatt tagttttaat aattactaac tttgtagaag gacctaaaat 263580 agtgtttgtt ttcagtgctt caactaatag taaaaaggaa tattttcagt gctttactgt 263640 atgagaggtg cttgcctaac gaaatacaca tctttttcac tgtactcatt tgtaacagat 263700 aatgtgggct cgtacacctc agtgttctga gaggggttgg taaacactga ccacatagag 263760 agagctgccc atctgccctc agtaccaagg cacatcccat ccatgcccta aaactcttgt 263820 aaatttctcc attcatacag gaaaatgagt atttcttaca acaatatgac cgtggaattt 263880 gattacaaaa acactcctgc tatccccaac ctgtgctccc agggctaaag acatatttgc 263940 aactcaggat tttctgaaga ttcacttgtt tgtactattg agggcaacag ttgttctcaa 264000 acaaggatgc agttcctttc ttcttaccct gcttattttt ctttttatta ttattattat 264060 tatactttaa gttctggggt acatgtgcag aacgtgcagg tttgttacat aggtatacat 264120 gtgccatggt ggtttgctgc acccaccaac ccgtcatcta tattaggtat ttctcctaat 264180 gttatccctc ccccagcccc acagccctca acaggcccca gtgtgtaaag ttcccctccc 264240 tgtgtatgtg tgttctcatt gttcaactcc cacttataag tgagaacatg tggtgtttgg 264300 ttttctgttc ttgtgttagt ttgctgagga tgatggtttg cagcttcatc catgtccctg 264360 caaagaacat gaactcatcc ttttttatgg ctgagtagta ttccatggtg catatatgca 264420 acattttctt taaccagtct atcactgatg ggcatttggg ttggttccaa gtccttgcta 264480 ttgtgaacag tgctgcaata aacatacatg tgcaagtgtc tttatagtag aatgatttat 264540 aatcctttgg gtatataccc agtgatggga ttgctgggtc aaatggtatt tctagttcta 264600 gatccttgag gaattgccac actgtcttcc acaatggttg aactaattta cactcccacc 264660 aacagtgtaa aagcgttcct atttctccac atcctctcca gcatctgttt tttcctgact 264720 ttttaatgat cgccattcta actggtgtga aatggtatct cattgtggtt ttgatttgca 264780 tttctctgat gaccggtgat gacgagcatt ttttcatgtg tctgttggct gcataaatgt 264840 cttcttttga gaagtgtctg tttatatcct ttgcccactt tttgatgggg ttgttttttt 264900 tcttgtaaat ttattgaagt tctttgtaga ttctggatat tagccctttg tcagatgggc 264960 agattgcaaa aatattcccc cattctgtag gttgcctgtt cactctgctg gtagtttctt 265020 ttgctgtgca gaagctcttt agtttaatta gatcccattt gtcaattttg gcttttgttg 265080 ctattgcttt tggtgtctta gtcatgaagt ctttgctcat gcctatttcc tgaatggtat 265140 tgcctaggtt ttcttctagg gtttttatgg ttttgggtct tacgtttaag tctttaatcc 265200 atcttgagtt aatttttgta taagatgaaa ggaagggatc cagcttcagc tttctgcgta 265260 tggctagcca gttttcccaa caccatttat taaacaggga atcctttccc cattgcttgt 265320 ttttgtcagg tttgtcaaag atcaaatggt tgtggatgtg tggtgttatt tctgaggcct 265380 ctgttctgtt ccattggtct atatatctta tttggtacca gtaccatgct gtctttgtta 265440 ctgtagcctt gtagtatgaa gtcagagaca caataaaaaa agaaaatttt agaccaatat 265500 ccctgatgaa cactgatgca aaaatcctca ataaaatact ggcaaaccta atccagcagc 265560 acatcaaaaa gcttatccac cccgatcaag tcggcttcat ccctggaatg caaggctggt 265620 tcaacataca caaatcaata aacgtaatcc atcacagaaa cagaaccagt gacaaaacca 265680 catgattatc tcaatagatg cagaaaaagc cttcgacaaa attcaacagc ctttcatgct 265740 aaaaactctc aattaactag gtattcatgg aatgtatctc aaaataataa gagctatttt 265800 tgacaaaccc acagccaata tcatactgaa tgggcaaaag ctagaagcat tccctttgaa 265860 aaccggcata agaaaagaat gccctctctc accattcctt ttcaacatat tattcaaaac 265920 tctggcgagg gcagtcaggc aagagaaaga aataaagggt attcaattag gaaaagagga 265980 aattcaattg tctctgtttg cagatgacat gattgtatat ttagaaaacc ccatcgtctc 266040 agcccaaaat ctccttaagc tgataagcaa cttcagcaaa gtctcaggat acgaaatcaa 266100 agtgcaaaaa tcacaagcat tcctatacac cagtaacaga cagagagcca aatcacgagc 266160 aaactcccat tcacaattgc tacaaagaga ataaaatacc taggaataca acttacaaag 266220 gatgtgaagg acctcttcaa ggagaactac aaaccactgc tcaaggaaat aagagaggac 266280 acaaacaaat ggaaaaacat cctcatggat aggaagaatc aatatcatga aaatggccat 266340 attgcccaaa gtaatttata gattcaatgc tatccccatc aaactaccat tgactttctt 266400 cacagaattg gaaaaaaact actttagatt tcatatggaa ccaaaaatga gcctgcatag 266460 ccaagataat cgtaagcaaa aagaacaaag ctgaaggcat cacgctacct gacccagctt 266520 atttttctac ataggatccc cacatccctg cttttgctag aatggaaact agacaaggac 266580 caacttttat caacttgttc atttctctat tcctagaaca cagcctggta caaaatttgc 266640 gtttaataat gtttgttgaa tgaatttgaa tgatggattt gtttagaagg tttataacat 266700 cccatgcctt atgagtttgt tgccagagga aaaaagaagc ctgtttttgg ttcataacat 266760 caggtatgta acctggaatt tggaatcatg agtttttatg catttgcttc atattattta 266820 tttttaagag atctttcaaa gtattgacaa agatacttta agattgagag cctccctgat 266880 aacccaggaa tgagagtttt agattaagtt tacaatatga ttgaaggcta atcatataag 266940 gagaaaaaaa taagaaaaag aagagaaatt tgaaaagaaa tctccaaaat ggccatggac 267000 atcagaacac tgagaattca tacacaaaaa tgtgttttgc ttcatacctg tctgttgcac 267060 atctatacat ttcatagatg cagaggaatt ttggctaaat tcctaacaca tgagaggcat 267120 tctgcactta cttctcaaat tagaattaac acatgagtat gtataagttg tttagagtgg 267180 gcatctattt aatgagttta ctggctgaat cttttaaaag aatgcaaaca taagtgcctt 267240 ttatcaaaaa tcaatgaaaa gataaaaggc cctgtagtgc atgctgtggt tcccacacta 267300 catcccccac atccacctga tgtcatcaca actgtctatg gtgtccattt gccactatgc 267360 accctgccgg gcagactcag gtgcctgcct cggcaaagac cctcagctca tgtgcaggta 267420 cagcctagaa gtgcatgggg gtgaacatct ctgaggcacc cttcaaccag tgagtactgg 267480 gagcggtaga taaatatcct agcctctcat ctttctacac aacagtggtg gtgcatattc 267540 tacacagctt ctcaaaggag cctcagaggg attgggcccc attagccact gtgataacca 267600 gctcagaaca cacacatatt agttgttctc cctttccttc ccaccctccc cattccctga 267660 ctgctagatc cagaagtcat cttccagatg aactacctat atccaaatcc taatctctag 267720 ctctggtttc ttaaacaggt cctatgaaat gcttgaaata aaaggcaaaa tggtttgtgt 267780 ctagaatcaa aggctgacaa tggcaagcaa caggcactaa aactatgacc caggaaaaat 267840 gcttttctgg aagacatcgg cattacctcc tagacacgga atacactggc ttcatcccag 267900 tagtttcttc acacacttta gatacgtgtc tcattaggat cacatatgac tcacctgatt 267960 tcatgccttg ccttttcttt ttattctgca gattcttcta aggagcctaa attcaccaag 268020 tgccgttcac ctgagcgaga gactttttca tgccactgga cagatgaggt tcatcatggt 268080 acaaagaacc taggacccat acagctgttc tataccagaa ggtgccacca tcatgccttt 268140 ctgattttcc tctccatgga tgtacctact aaagtacact gagtcagatg tactgtggga 268200 atggaagtga tttgttgtga tttatgcaat caatgaatat tcattcactc atttattgaa 268260 aaaaatatta atcaagccca tcctatgtgc tgagtactat tttaggccct ggagatatag 268320 cagtgattac aaaagacaaa atccctggtc tcatggagat ttccttccaa tgcagggaga 268380 caggcaataa aaattgaatt aaatgtcagc tagtaatata ggttattaag aaaaataaag 268440 ccagaaagca gcatatcagc agtgtgtggg agtttgtgta tgtgcatgag aatgtgtgag 268500 agtgtgtcaa agtgtgagtg agagcatgta tggatacacg tgggcatgtg catgtggatg 268560 agagtgtgtg taaaaggctt gaatgatgct gaaatgcgtg gtcctaggag gcctctctat 268620 tgtggtgtcc tagaccagag acataagtga aacgggacag gccacgtgag tatctggggg 268680 aaaggctatg caggcagagg aaattgcaag tacaaagtcc ctgaggcagt cttggcatat 268740 ttgagggatg aaaaaggcca gcactgaagg cacaagattg aaagtgagga gagtgatatg 268800 ggaagggatc agagagttac ttagggactg accatgccaa acctcatagg caagggcaag 268860 gctttgaatt ttactttatt tgtggtggaa agctgtaggt gtttttgaaa agatatatgc 268920 tttaaaagat gtagctttgt ttctaaccag ataatacact ccttctctta aatatattca 268980 gtaaaagact gtagtacttt ttcattttta ccagtgaccc tctaaaataa cagaggaagg 269040 gtgaaacaaa gacctctcaa tataggtacc atccaagttg tttatttctt ccccttcacc 269100 tggcattatt ttcatttttg tttactctca ctgtgtatat ttttcccttt tttacatttt 269160 aggcttaaac acttcattat ctcctgtttt ccacccaacc cccagagaag gcctaagcca 269220 agatgcaggg ttagtgagga ccctttatcc ttggctcaag gtgttcgtta gtcagaggat 269280 gacattgtct atccaaccga agagctggaa tagggaagga agatgcagcc agcagttaag 269340 ggtatgagct cagggctaac aaacctgcac ttcagtgtag ttctgcactt tctcaccaag 269400 gaatactagg gaaattagcc agtttgtgta caactcagcc tcctcatttg cagaaaggag 269460 ataatggact tgcctcatga cttcttgtga ggatcatatg agataaccca tgaaaaatac 269520 ttggcagagt acttgacaca taataagtac tcactaaatg gtagctggta ttcttcttat 269580 cggtagtata gtgataattt taaaataatt atgatataga aatccagttc ctggactata 269640 aaatgactat aaattgtata agaccattta taccagtaaa ttgttataat tattttaatt 269700 attggtataa gagcatttta atgcagagct gctgcttaat ttgcagataa aaaaatactt 269760 ggagttagca accaagcaga ccttccccac ctttcagtat aagagaggtc tcttggatga 269820 agtgaagtga agatgaaatg tttgggcacc aagtatacta tatttttcct taaggctgac 269880 accacagaga ggttggggcc agtaaacaga gttgatttct ataaatacat tcagacatga 269940 agttagtatg tttgatgaca cttttgaaat gtgtggaatc attaagttat ttgtacaggc 270000 acaattagcc aaactgtaaa gaaaagtagc agaataacct cttaagctgg gcccacttta 270060 tgaaaataat tttttgctac ctcaatattt accaaatttg atgagcaaaa agagaaatcc 270120 aaaggaatga agccttgata aatatatatc ccttgccctc atcaatcagg gtcacataac 270180 tctgtccaca ggcatcttat gcacactcca gtcatttcag catctctggt tcaaatccag 270240 gatctacact accaaggatg ctgctgaaag tgtgactggg taaagggaaa cgttcagaca 270300 tattcagaaa gatgtcttag attttgccct ggtagtgttt ggaatcccag gagggtaagt 270360 acagcttcat gattaagtgc caacccaaac ttacaaaatt agatatttgt gttttttcta 270420 taaaatataa ctattttgaa tatcttagcc aaactactat gagcccacag cccagtttat 270480 ccaagaagga taaaactgag ggattaggag tatcaggact ggactggact gattagtgta 270540 cagttatatt tgatttctca ttgcccactt cacagagaag acaatacaaa tgcactttct 270600 gactcttatc actgtttctt agaactcagt tgccaggcaa ctcctgaaac tatagaaaca 270660 tgcttctcat ccctgacaca taaataaaac tctgagatga ttttatccaa agtcagagtc 270720 agtgggcagt gcagttgttt cagtttgctg gcctggcctc agtatctaaa gcacaacaga 270780 acgtgaacat gtcaggctgt caacaggaca gttcaggcac agccctacag gcagttgtgt 270840 gttttgcctg gctctgctcc ttgccaggtg gctggcagaa aaggcagcct ccacatgtta 270900 gagcagcaga ttcaaaacag tgtctgccat cctgtgatga cgatagtgcc aaattcagcc 270960 tctgagcttg caggggactc aggatgaatg cacattacag gcatggtaaa aagaggctct 271020 gggaagcatg ttcgagctgc tctgctctca gctccttgca tgtaaatgct gtgtttttaa 271080 aggaagtggg catgtgaaca ctcagtcctt aaggctgtat cccccacctc ttccataccc 271140 attcaacccc acttcaaaaa ttaccctggt cttaagagaa atttcatttt ctatacaagg 271200 ttgtgtggaa aatcagtagg gagaaagggc attattactt tcatttttct ttaacaaaag 271260 tattaaattt aaagccaaaa acgtgcgctt tctgtcatga aaacagctgc ccttaaaaac 271320 ataaatgatg ttttattttt attactttta tctagttggt tgtctttaga tgaaaaacat 271380 ttcttctgct ctttattctt atttttaatg atagtctctt tctatggttc tcaccccttc 271440 catttcacaa gatagtctgg gagcaaacct aaagcactta acttttggga gtaagagcag 271500 aggggagctt ccatacattg attttggtca tctgtagaga cattcaaccc agagaaggca 271560 agtgacacag tatctgtttt atgagctaat ttgggttctt gtctacattt aatagtttaa 271620 aatataagtt ataaatattt atttaaaatg aaattcaaca ttggttcatg aagaaagagg 271680 ttggaagtag tgttttgaac tagctgtttc tgatccatca tgcttaaaat aaatgctctg 271740 tttgtcctgt ggagttcatg gatttgggat aatctaaaca gggtttttta aacagtcctc 271800 atggggaaca aggtactgac atgcactgtt gagaaattct gtgaatcatg aaagagctaa 271860 tcttttagaa atccagacct gttaagcact aatctacatc tttggaatat cttaatactt 271920 tgagttttct aacttttata ctatcactta tgctaagtac atttgatatc ccttctatta 271980 tgtgaaagcc tcattttctg ggcaattttc ttacaactac tctctttaat gcactcttac 272040 ttaatttgaa agtaaatatc aaattaagca tactatagtt caatgaacca cccacctatt 272100 cctaattttt ttaacatttc tcttctgact ctacatacac acatacttac acacacacac 272160 acaaacacac cttatctttt cttctgcctt ttgcccattt actttttgca tcagagatga 272220 atctctcatt caagcatatg caactttttt tttttttgag atggagtctt gctttggcac 272280 ccaggctgga gtgcagtggc tcgatcttgg cttactgcaa actttgcctc ctgcgttcaa 272340 gcaattctcc tgcctcagcc tacctaccga atagctggga ttacagaagc atgccatcat 272400 gcccagctaa tttttgtatt tttagtacag atggggtttt accatgttag ccaggctggt 272460 ctcaatctcc taacccatga tccgcctgcc tcagcctccg aaagtgctgg gattacaggc 272520 atgaaccacc gtacccagcc agcatatgca acttttaaga gtctcaacca aagcagcaat 272580 tcactgtctc agaccctgga gtctctgcca tttaaatccc aatttccttc caacagctga 272640 ggagcagctg tctcaaggac cctctgatac tacacaagtt ttctcctagt gccaagcaga 272700 ccagcctgag aaacagctat aagaaggaaa taggcgtctt ctcccagctt ggcatccttt 272760 ccttccaggc cctgccttcc ctacaacctg cattgtcttc attgtccact gctgcccagc 272820 acccatccca cagagggatg gtcccaaacc tccacagtct ggcctgtgag ccacaggcgc 272880 ctctgcctgc acagggccat tcctacctca tcttccacaa ccacagatta catggtttta 272940 tgtccctttg acttatatat tgtcttctca attaataggc tagtgaataa catggagatg 273000 atgaactacc tcacccaagt agcaattcta atttaagaaa attttcctgt cattccattg 273060 ccttttactt ccattaccac actcatgccc atacttcctt acctcaatcc ctttgacctc 273120 tctgtttatt cccttccttg ccgtattgcc atctattaaa cttttaccca tccttcaaga 273180 atgctaaaaa catacctcca ccttgaagcc ttccatgaag agccagagca atcattccct 273240 cttctgaact tttaaggacc ctagagagca ctactaatga gcacttaccc acattgcttt 273300 gtaatatggt tttttactct ttccttctga ggcaggagga attccttaga catctatgaa 273360 tcccatagtg tctgtcatta tgttttagac ataaccaatt ctcattaaat gtcaatagaa 273420 tgaatataag aggcccaaaa aactactcag atgggaattt gagtcttatt ttagcctgaa 273480 attaggggac cacatcttac ttatctttat atctgcacag cgttggtgct ggatataatg 273540 catcactctg cctggagcac acatcaactt gtctcctcag tttctttcac cataggctgg 273600 tgaaacagcc aggtctaaac cttcactgtt ctctgggaat ctctagtttg ggggtgattc 273660 tctgtactgt tttaatgaac atttttaaaa tgtccctaag tctcagaacc ttcatctata 273720 caactggcat aataaagtac ctaccatagg aatcgattta tgagcaggca tagcatattc 273780 attcaataaa cggaagtttt accataggca gaagtaccaa acggcctcgt agcagtcgtc 273840 agacactgat gatactgtcc actgatgtga tatgtctcgg aaatgatgtt actaaaatac 273900 ctcttcacaa aatatttgtc ttccaattta ttgaatcaga ctatcaagca ccttacttgg 273960 acttaagcta caacatgatt tttggaacaa ttaatctttt tttaaccctt cattttagga 274020 acactcaaga atggactcaa gaatggaaag aatgccctga ttatgtttct gctggggaaa 274080 acagctgtta ctttaattca tcgtttacct ccatctggat accttattgt atcaagctaa 274140 ctagcaatgg tggtacagtg gatgaaaagt gtttctctgt tgatgaaata ggtaaatcac 274200 aggtttttgt ttcatttgac atagttttag actaaataaa tggggaagcc tgcaaggtcc 274260 aagtataatc aagtaggaag actttgtaac agtgttctat agatacatgg agatctgttt 274320 tacaggagat gggatcagct ggtgaacaag aggaaaaggg cagggggaac ttaagttgac 274380 tttaacataa agtagcctgg cagtaaatgt tgtgaagaag agaataggaa ccttgtggag 274440 tcttttcctt taggatatct ttgaagctgc gttgtgtttt tatgttccac tgcaaagggt 274500 gaacttaata tattcttagg atttcttact tcctaattat ttgataggat ccttatattc 274560 aaattcactg aaatacgttg gcctttgacc tctaccattg ctgtaatcaa agcctagatt 274620 ttctttatca caaagcataa tcattctgga attttacatt tacaaaacag ccacagttac 274680 tttaaagaca tgtttattag atctcagaac aaatactgga gacaatcagc tcagtgaact 274740 aagtgaaaga tccaaacaga ggatcctttg cccatcatat ggacacaagg tggaaacaaa 274800 acaaataaaa caaacaattg taattagaat agtcatgttt ataccttaat agtataaata 274860 gcaaaataga aagaatcaaa gaaggacttt gagtagctga aattagtgcc tcaaaatcta 274920 tccacaaaag ctcatttgtt gcttatagga atttctcgtt gcttctccca aatgtattgt 274980 tctttttatg tggttttcta ggcataagct gactggaaga cataggagta tgtggctaga 275040 acttacagat agaaacaaat aaaatctaat aggctgactt taagggagaa gattaagaga 275100 actgtatcaa gcagtaaaga taacccaatt gctttgcaaa gacaatttag tatgtgtcct 275160 aacatcactg ggtatagctg ttgagttgaa actaaatggg atagcagaat gggatagtag 275220 caagaacact gggttaaaac ccatgttcta gccctgttct ctgccaatag ccagtcctac 275280 tcatttacct ggctgacatg cctgtcatgt gtcacgcact gttctggtgg tggtggttat 275340 agaataagta caatacagtc aaagagggaa gtcaggcatg ttcacaaata attgcagtgc 275400 agcgtgatag gtgttagcct ggaaatacgt ggaatgcaga gctgcaaagg tggtggccaa 275460 aggcgtgaat gactgacagg cctgagggat gaggaagggc tgcacagaga tggtgacagt 275520 ttagttacct ctgaactgga attggactct ccctattttt aaaaaagtga tgacccacag 275580 tggtcaaaag catgagtgag tattgtcagg taccacagtg gacttgcctt tcagtaacta 275640 ctaagttcca acagtaactt agtagttact tagtaattac aacagtaact tagtagtccc 275700 aacatgttca gggactcagg agcagttagg aagccctcct agtcagctgg agaaatcatc 275760 agtagttgtt tgtgccccaa aaaggaattt ggactttaac tgtcacgagg tacctttgag 275820 gatgtttaaa tagggaaatt acttgaggat actaatagtt aacagtcaca aaagtcttac 275880 catgtgtcag gtataaaaac catcttttgc aatcacactt tacagataat gaaaccgagg 275940 cacagagcag ttaaaggact agttcaagtc aaacagctag tagatagagc tgggatttga 276000 acctccagcc tccatgctct tactcttgag gctttgcagt accacttgtc tctttattaa 276060 tgctcagaga aattaatctt gttgcaatgt gaaacgtaga ttggagtggg acggactaga 276120 ggtagaagag gttaaaagac tgagatgatc aaggtaaaag attatgacag gtagctacaa 276180 ctagcacaat agttgtgggg caaggtgctg agagtgaaag agaacaaaga actaatgtaa 276240 ccctggtaga tcttgagaaa gttgtcaatc attataagcc tcagcttcct cataaaatat 276300 gtatgtatgg tactacctca cagggctatt ctttggattt gaagtactat attagttaga 276360 catttgtcat tcattcaatt cattcagcaa atatttatta tgctcttctc tcaggccagt 276420 caatgttctc catgctgggg atagaaactg tcttccctgg tgggatttaa tcccaacgag 276480 gatggaaagc gacaatgcta tggagaaata taggaaagga gaataggagt gttggagagg 276540 ttgcagtgtt gagttttcag gattggcatc cctgaggcag tggcatttga ataaagaagg 276600 attggagagg ataattatgt gtgtgtctca gggaagggca tttcagcaag ggggcacgcc 276660 agaagaaaga tctcaaagta ggagcatgct tttcctcact caatgaacag caggccggcg 276720 gtggagtggg cacagagtga gcgaggagac tggtatgaga ccaaatcgca cagacaagac 276780 agtcaaatct acccaaccat tgccaaagac tttggctttc acttggagtg aggtaggcag 276840 cctttggagg gttttagatg atgagcgatg tgatctaacg taagtgttag gataatcact 276900 gtgtcagttc gcttgaggat tgcatggaga atagactgga gggggacaaa gaccaaaggg 276960 gtacagtggg gagacaaatg aagcaagaag aatgaaaaag gataatggcc aggaccaggt 277020 tattagtggt gcaggcggtg ggacatggtt ggattctgtt atatcttgaa agtacagctg 277080 acggaatgtg gattagtgag gaaaagatga gccaaggaca agttcattgt ttttatcctg 277140 agcaactaga ggaattgagt cctcgttaac agagatggaa aagaggaaag gagagcaggt 277200 tttggagagg aagagcaagg gtttgtttgg ggatatatta agtttcagat attttttaaa 277260 tatctcacag gagttgtcaa tatagcatgt agatttatgt atagagataa aggagaggtc 277320 attattatgc ctgtaatggt atctcacagg aggtcattgt tatgcctgta atggtggtac 277380 caaatctttt ccaaaaggac cttgtctcat atcctctatt tttcaaatgc agcataagta 277440 atgagttata gaaaatcttc cattaaaaac aattttatag tttggtcact ttaaacggtt 277500 aagctttgat tatcaggatt cctgaatctc caacaaatcc agaagggtga ggaattattg 277560 ccattatatc ggcatatgta gtttggccat tttgcatatc cttccaattt aattttcaaa 277620 atgtagtcat gattcatcaa attttgactc tccctgtttt taaaaaggtg gtgtcgaccc 277680 cacagagggc aacagcatgc tcctccacca taaggcctgt tttcactgtg ggtgcacaca 277740 agagcttccc tctttggcca acagatttga cagccagtaa gagctcctca ctgtgtatat 277800 ctgtaaagtt atctccagtc aacgctaggg atgcacactc tgcaacactc taggtggcct 277860 tctgtatata tggcagaaaa agaaagtaaa ttttactctg tatctgcaag tgattttcaa 277920 aaccctcagt aatgagatcc aactagcaaa aatttaccag gaactctcta gaatataaat 277980 ttagacatag ttcctagctt tggaatccat atttttcttc atcagcctct gagaaattgt 278040 ggtctttgag gtcctactaa gcagaatgca acaaattttc gtggaactgt agagtatatc 278100 aatagaacct gaggaaaaca atgtttcaag ttgttcatgt gacagtcaaa aagacagaaa 278160 acactgaatt gtcaccattt gtgagactag cataatgctt tcttccttct tatgtcagaa 278220 gaaaatatca catgtggcta ggaagatcac aaagctaggg agcattagca gagtgtgcag 278280 gaagattgta tgagaagatt gaagaagagt aaaaaaggat aatggctagg accaggttat 278340 agtggtgcag gcggtgagat atggttggat tctgttatat cttgaaagta cagctgacgg 278400 aatctgacgg aatatggatt agtgaggcaa agatgagtca gggaacaaca cagaaatgag 278460 gtaaacaggg tctctgcccc caggccatac atagttgcaa gaaaaaaggt ttctctaccc 278520 ctagttccga agcagcccca tgtctaaatt ctgtaagtct ttctgactct ctgttttttc 278580 agtttcaagt gaaaataaat tcctttgcca aaatcctgat gcatttatga tatcagagca 278640 aaaagaaata tacaacatgg cagatcttgt aaatagtgat cagatgtttt actccaaaag 278700 gaatttttgt aagggcttat ttagaagtta aaaacaagtc atccttgagt taaaaaaaaa 278760 agttactctc ttataaagtg aaagttataa taagaaaaat attggaagaa ataagagcat 278820 gaatgatcaa aaatgtagaa agtaatttgg tcttctgaga agaatgcctt ccattaatat 278880 taaattgtgt ctgtctgtgt actaatgctc tgttgaattg cacagtgcaa ccagatccac 278940 ccattgccct caactggact ttactgaacg tcagtttaac tgggattcat gcagatatcc 279000 aagtgagatg ggaagcacca cgcaatgcag atattcagaa aggatggatg gttctggagt 279060 atgaacttca atacaaagaa gtaaatgaaa ctaaatggaa aatggtaaga tgttgctaca 279120 ccttacactt tgacttttct ttctatttca acaaactctc tctcatttat cattagactt 279180 tcctttgacc taataccaca tgttcatgct gtatgctcca taatttctta attgagaaaa 279240 cattatttaa ccggtaaaat attgtcttga aattctgtaa gacaggagat gcttatgtat 279300 atatggaggc ctgtggaagg aaaggaaaac tatttctcca ttcattcttg ctgtccagtt 279360 taactttaga gcaaaattat agactggcca cttagctgtc tttggggatg tggataaaaa 279420 tgggaaagtt tgtgatccag tcaacagtga ctatggccaa atattttccc atgatttcag 279480 ttgctgctac tcaaaggact cccactaaaa caaattcata cgtgtctata ggaaaacaga 279540 gggagggaat ttgtctctta gaggtttcag aaggatgttt tgttacatac ctcagagaag 279600 aatcaagctg agattcttat gtaggcaatt agagagcatg gtaccagttg acctctgaat 279660 ccctctcttc cttaccaagc atatggaact cagcattttg ataaatttca catggcacat 279720 aacaagagga aaaacaggag tatcatgctg ctcccaatat aactaattct aaatctgtct 279780 aaccacagcc acagccacag ccacagccaa gccaagcagt ttctggccac tcatcaggtg 279840 atgcccagca gcctggcaca gatcactccc agaattttga gacaccagga cattcagtga 279900 gccactgaaa aagatgccaa ttttgtcatt agaggaaagt taagtttgga ggaaatttga 279960 gtagttacaa tactgggctt tgaggctcta ttttctgaat cattttaatt tagatatctg 280020 ttctgtaact tggtacaaat aaaatgcctg attggatgct aagtcaaaca agactgtcta 280080 aatccaagct acaatcaaac attatttaac aacaggtact gaaataacta ctatgcagaa 280140 ggcactgtgc taaatgcctg aggtggcggt tctcaaagtg ggagccacag acccttgagg 280200 gtccctgaga ccctttcagg gagttcagta ctattttcac aatacactaa aatattattt 280260 tattaactat gttgaaattt aacttaatgg cacaaaagca atgctggaaa cactgctggc 280320 accttagcat gaagcaaggc agtaggatca aattttacta atagtcatgc actcccaatg 280380 aagaaggaag aaaaagccag tttcacgttt gaagttcttg atgaagctgt aaaaattgtt 280440 aattttacta aacctcgacc tttgagtaca tagcttatta atattctgtg tgacatatgg 280500 gaattacaca ttaagcatgt ctgctgcgta ctgaggtatt gtatttgtct tgaagaaaag 280560 cgcttaaatg actgagttgc cagctgaact agttgctttt attgcttgga gcaccatttt 280620 tacttggaag agccattgat aaactggcag atggttattc atatttgaat tggcaaacat 280680 ttgtcaaaaa agaatgaggc aagcttgtcg cttcaagaaa aacaactgac agtatttttt 280740 gcaatggaaa aaatttgact tttcaaagca attcattttg cctttttcga aaatttgtgt 280800 ctccaaccgt gagcttgata gtgttttaat atttgaagac ttttcttgaa gagattgatg 280860 gtgatattaa tgaaagtgac tttttaatta tattgtgtaa taaaatgtat gaacatttag 280920 aaaaatctac aactcagtta accaatattt tccaaattac taatacatga tgtaatcaaa 280980 tcatgcatgg ggaaatgatc cattcaaagt actagataga atcgtgaatt tttttaatga 281040 tcaaaaattt ttttgtatat ttattgtgta caacatattt ttttgaaata tggatacatt 281100 gtagaatggt tctatcacac taagtaacat atgcattacc acacatacct ttttttgtgt 281160 gttgagaaca cttaaaatct actcagagat tttcaaaata caatacataa gcattaacta 281220 tagtcaccat tttgcacaat agatttctta aactcattcc tactaactga aaattttaat 281280 tctttcatca atatctcctt aactctgcac cctgcccaca acccctgata accaccattc 281340 aactctctgc ttctgagttc aactttttta gattctgcat ataagtgaga ttatgtggta 281400 tttgtttttc tgtctctgga tcatttttct taatataata tcctccaggt tcatccacat 281460 tgtcacaagt gacaggatat ccttcttttt ttaaggctga tagcattcca ttgtatatac 281520 ctaccacatt ttctttatcc acttatccat taatggaaca taggtcgatt ctatttcttg 281580 gctgttataa gtaatgaaca tgggagccca gatattctgg ctcaacatac tgatttcatt 281640 ttccttggat atatacttag tagtggaata atataatgga tcacatggta gttctatttt 281700 taatcttttg aggaagcttc atattatttt ccatagaggg tatactaatt tacactccca 281760 ccaatagtgt gcaagggttc ccttttgtcc acattctcac caacacttgt tatctcttct 281820 ttttttgaaa atagccatcc taacatcttt gtgcactcta tgccttctgt gagctgatag 281880 ctcattgtgg tttaaattta catttccctg atgattaaag atgtcaagca tttttcatat 281940 acctgttggc catttctata tcttcttttt aaaaatttat attcaggtcc tttgcccatt 282000 ttttaattgg gttattttct tgttattgaa ttgttttagt tccttatata tttcagatag 282060 taacttctta tcagatgtat gcaaatattg tctcccattc catagagtgt ctttttactc 282120 tgttgattgt ttccttggca gtgcagaagc tttttagttt catgtaatcc cgtttatcta 282180 tttccacttt tgttgcctgt tcccaatgga gtcatatcca aaaaatcatt gcccaaacca 282240 atgtcatgga gctttttcct atattttctt ccagtagttg tacagtttca ggttttacat 282300 ttaagtcttt aatcgatttt gagtttattt ttgtatatga ggtaaaataa gggtataatt 282360 tcattcttct gcatatggat gtccaatttt cccaacaaca tttaaagaca gagtcctttc 282420 cttactgtgt attcttagca cctttgtgat aaatcaattt actgtaaatg tgtggattta 282480 tttccgaaca ctttattctt ttacattggt ttatgtcatt tttatgccag taccatgctg 282540 ttttgatgac tatagctttg tattatgttt tgaggttggt agagtgatga tttcatcctt 282600 gttcttcttg ttcaagattg ctttggctat tcatagtcta ttgcagttgc atacaaattt 282660 tagaattgct ttttctattt ctgtgaaaaa tgacattgga attttgataa ggattgcatt 282720 gaatctgtag attgctttag gtagcaggga cattcgaaca atattaattc ttctaatcca 282780 tgaacatggg ctatctgttc atttatttgt gttgtcttca tgttttacag ttttcagtgt 282840 tcagatcttt cacctttttg tttaaattta tttctaggtc ttttatttta tttttatttt 282900 tatagatatt gtgaaaggga tttctttatt tctttctcag attgttcctt attagtgtat 282960 agaaatgtta ctgatttttg tatgttgact ttgtatcctg cagctttact gaatttgttt 283020 atctgttcta gcaatttttt gttgaagtct ttagggtttt ctatatataa aatcatgtca 283080 tctgtaagca aggacaattt aactttttcc ttctcaattt tggatgcctt ttatttctct 283140 cttttgctta attgctctga ctaggatttt gaatcgagta gaatagagta gaggagttac 283200 attgaataaa aatggcaaga gtaggcatct ttgtcttgtt cctcatctta gaagaaaagc 283260 tttccacatt tcactgttta ttatgatgtg agtttgttat atatggcctt tattgtgttg 283320 aaatacattc cttctatatc taattgttaa gggtttttat catgaaagga tattgaattt 283380 tgacaagtgc ttcttctgta tctgttgaga tggttccatg gttttcgtct cggttctgtt 283440 aaagtgatgt attatgttta tgtatttgtg tgtgatgaac catccttgca tccctggaat 283500 aaatcctact tgatcatgga gaatgttcct tttagtgtgc ttttgagtta gtttcctagt 283560 attttgttta agatttttac atctgtattt atcagagata ttagcccata attttctttt 283620 cttgtagtgt cctttcatgg tttgggtata agggtaatgc tagcatcaag aaatagtttg 283680 gtagtatccc cttttcttcc actttttgga aaagtttgag aaggattggt gttccggtga 283740 agcttccagt gaaactgtca ggtcctggac ttctctttga tgacagactt tttattactg 283800 attcaatctc cttacttatt attggtttat tagattttct atttcttcaa gaaagtctta 283860 gtaggttgtt gtgtgtagga atttattcat ttctcatgca tataattttt cagaatggtc 283920 tcttatgaac atttgtattt ctatggtatt ggttgtaatg tctcctcctt catttctgat 283980 tttgttttta atttgggctt tctctttttt tattatttag tctagctaaa gattggttga 284040 ttttgtttat cttttcaaaa aaacttgttt cattaatctt ttctactgtt ttaatgtgct 284100 aactgaaaag cacattaaaa ggatcattct ccatgatcaa gtaggattta tcccagggat 284160 gcaaggatgg ttcatcacac gcaaatacat aaacataata catcacatta ctagaaccaa 284220 aaacaaaatt atggaaccat ctcaatattt tctattctct atttcattta tttctgttct 284280 gatctttatt atttccttcc ttctatgaac tttatgctta gtttattctt tttctggttt 284340 cttcaggtaa aatgttaggt tattcatttg agatctttgt tttctgatgg aggcatttat 284400 tgccatgaac ttccattgct cttagaacga cttttactgc attccttaag gtttgctatg 284460 ttgtttccat ttttgtctca agatattttt gattttattt tttacttttt aactattttt 284520 ttaggttcag agatacatgt gcacgtttgt tatataggta aattgcatgt cacaggggtt 284580 taccatacag attatttcat caccaggtaa taagcatagt acccagaagg tagttttttg 284640 atcttcacct tccttccacc cactaccctc cagtaggccc caatatctgt ggtttcagtc 284700 ttcgtgtcca tgtgttctca atgtttagct cctactaata agtgagaata tgtggtattt 284760 gttttcctgt tcatgcatta gtgtgcttag cataatggcc tccagctcca tccatgtgac 284820 tgcagaggac atgatcttgt tcctttttac gcctgagcag tattccatgg tgtacatata 284880 ccacatttcc tttatccagt gtaccatttt ctttattcca tgtctttgct attgtgaata 284940 gtgctatgat gaacacacgc atgcatgtgt ctttatggta aaatggttta tattccttca 285000 ggtatatacc caataacggg actgctgggt caaatgacaa ttctctttta agttctttga 285060 gaagttgcta aactgcttgc cacaatggct gaactaattt gaattattac cagcaggata 285120 taagtgttcc cttttctttg caacctcacc agcatctgtt attttttgac tttttgataa 285180 tagcctttct gactgctgtg atgtagtatc tcattatggt tttgatatgc ctttctctct 285240 aattattagt aatgttgagc attttttctt acacttgttg gctcatgttt gtgttctttt 285300 gaaaagtgtc tgtttatgcc ttttgtccat tttttaatgg gactgtttgt ttttggcttg 285360 ttgatttaaa gttccttata gattctggat attagacatt tgtcagatgt atagtttgca 285420 aatattttca gccattctgt agattatctg ttttttcagt tgtttctttt gctgtgcaga 285480 agctctttgg tttaattaga tcccatttgt caatttttgt ttttgttgca attgtttttg 285540 gcatctttgt catgaaacct ttgctaaggc ctatgtccag aatggtattt cctaggtttt 285600 cttctagggt ttttatagtt tggggttttg catttaaacc tttaatccat cttgagttga 285660 tagtcgtaca tgttgaaagg aaggggtcca gtttcaatct tctgcatata actagccagt 285720 tacccagcac catttattaa acagtgtttt cctcatttcc tgtttttgtc aactttgtca 285780 aatattagtt ggttgcaggt atgaggcttt attttggggt tctctgttct gttccattga 285840 tctatgtgtc ttctttttta accagtacca tactgttttg attcctgtag ccttgtagta 285900 taatttgaag tcaggtaatg tgatgcccct gggtttattc tttttagtta ggattgcttt 285960 gactatttgg gctgtttttt gcttccatat gaattttaca attgtttttt ctaaatctgt 286020 gaaaaattac attgataatt tgataggcat tgcattgaat gtgtagattg gcttgggcag 286080 tatggtcatc ttaacgatat tgattcttct aatccataag catggaatgt ttttccattt 286140 gcgttatctg tcattttctt tcatcagtgt tttatagttc tacttataaa gatatttcac 286200 ctcctttgtt aaatgtattc ctaggtttct gtgtgtgtgt gtggctataa taggctatgt 286260 taacctgata acaatttaac tttcttgcat aaaaaactct acacttttac tccacatacc 286320 gcccccccaa acacatttta aatttttgat gtcacactta catcttttta tattgcatat 286380 ttcttaacaa attattgtac ctagtattat ttttaataat tttatctttt aaccttcatt 286440 ctaaaataaa agtgatttgc atattaccat gaaaatatta gacaggtaat gtgatgcccc 286500 tgggtttatt cattttagtt aggattgctt tgccaattgg gctgtttttt gcttccatat 286560 gaattttaca attgtttttt ctaattctct gaaaaattac attgataatt tgataggtat 286620 tgcactgaat gtgtagattg gcttgggcag tatggtcatc ttaacaatat tgattcttct 286680 aatccataag catggaatgt ttttccattt gcgttatctg tcattttctt tcatcagtgt 286740 tttatagttc tacttataaa gatatttcac ctcctttgtt aaatgtattc ctaggtttct 286800 gtgtgtgtgt gtggctataa taggctattt taacctgata acaatttaag tttcttgcat 286860 aaaaaactct acacttttac tccacatact ccacacacac acacgtttta aattttcgat 286920 gtcacactta catcttttta tattgcatat ttcttaacaa attattgtac ctagtattat 286980 ttttaataat tttgtctttt aaccttcatt ctaaaaagtg atttgcatat taccatgaaa 287040 atattagact actttaaatt ggactgtgta cttactttta ctagtgagtt ttatactttc 287100 atatgttttt atgttactca ttagcctcct tttctttcag ctaaagacct ccctttagca 287160 gttcttgtaa gataggtctg ttggtgagga atggttaatt taaatataac aaagtacaaa 287220 aagttcatca gtagagtttc aggtttcatt tttccactaa cctgtaagaa tttatcattt 287280 gagttttagt ctattgttaa acagaaatgt tcacaattat gtgaaaagtt tattaaaata 287340 ttcctcattt tcctcattat ttatctgtgt gaggccaggt tttattcatt tacgaaaata 287400 gcacattcta atagatttaa ttcagaagca gttataaaaa tacagtcatc ttcctttaag 287460 tctgacatta aataaatttg caaaaatgta aaacagtatc actcttctca ctctcttttt 287520 tgttgtttgg gaaagtacaa taatttttat gaaaatatat tatttaacaa aatcaattta 287580 ttattttcag tttaaaaata aggattttaa aattttttca tttcaatttc taatactgta 287640 aatagtgata ggtataaccc aactaaacca aactctttaa gattctcaaa tttttaagag 287700 tgtaaaggag tcctgaaata aaaaagttaa acaacctaga aaaaaacaaa gatataaatc 287760 agcatgttag cattcatcaa ttcagttacc atcatttcat ccctaaaagc catggcatat 287820 agttacgtct cactgagcca ccactttgaa actcccaccc tgtgccaggt acttgtgagc 287880 atgtaacttt gttaatcaac tgttcagggc tatatcccaa catggctttg ttgcactttt 287940 cgtggcacct ctgctaaatc tcgttaggta gaccaaaggg gtcagttaac tttttcttta 288000 taccttttat tcatgatatt tataagtttg gtaatttaca aaggtcttgg acaaagacca 288060 ggggcttata tataataatt tatttatctc ttgaagaaac aaacaatata attggttatg 288120 aagcacaggc gtcataagca gaaaacaggt ttataggtaa agggggaaga cctagtgtgt 288180 gtcgcttgca tcaggaattc atgttaccat ttggcaatat gaatttgctt agcagtgtgc 288240 ttttttttct cccccccaca ggatcttgct ctgtccccag gctagagtac agtggcccaa 288300 tctcggctca ctgcaacctc cacctccaga gttcaagtga ttctcgtgcc tcagactcct 288360 gagtagctag gattacaggc gcaagccacc acacccagct aatacagcta atttttgtat 288420 ttttagtaga gacagggttt catcatgttg gccagactgg tctcgaactc ctgacctcag 288480 gtcatctgcc aacctcggcc tcccaaagtg ctgggattat aggcatgagc cactgtgcct 288540 ggctgccctt tttagtaaat acattttgca tgaccatgtg gttgtttaca gctatttatc 288600 tagtaaacca ataacttaca gctttttaaa ggcttaatga atagcatgga attattcatg 288660 atatctgtgc catatcttga ggacccactg tatacctgat attgcactgg actttggaaa 288720 tgaaaaataa tgagtgatct tggggaattt acaatgtaac atagaaaggt gtgtatcact 288780 aaatttgcac aatgaaacat aattaataat agaagaagta tattatctgg cagaatagag 288840 tggggaaaag taccagcaaa gacttagaat accagctctc ctcaatactt gcacttagac 288900 ttggatgaga aacagttccc cgcacaggca gatgacaggg ttaggtatga taggagccac 288960 gtaagtagga gccactcgaa atctgagttt ggtgtggctg gtgtggaggg ttgagggaat 289020 atgaagagag gaccacaact tgaatcactg agggcccttt tttgatccta ttagtgaaat 289080 ctttaaagaa attgtattgg tgacaataac agagaaataa gggctttgag gatgaaaaca 289140 taggctttaa aaaaaaaact taagaaaaaa ataataaagt aagttcagta ttcagtgtcc 289200 tgccttaaag aaagcatttt aggcatgcaa atatcccata tattcagagg cttctataaa 289260 aaatacaaac aaaccctgtc atatacacat gaggcaaaaa aagatacttt gtgagtagaa 289320 actattgagg taaaagaaaa acttgtttta gaagctgaag gcccagctgc tgacttaata 289380 aaacaaatta tgagaatttt gtttatgcga aaatccatgc tgttgaaaac gcgagtgttt 289440 aaagttttct ataaacagga acaaggtgtt ctaccaaaaa aaagtataaa agcacattga 289500 ataactgctt tgagtatttg acttggagga aactaccatc actagttgag tatacctctt 289560 tgatagcaat atgtgttaaa agtctaacag tctcactcta cccctccccg agaaggtaaa 289620 ggaatatcct gaccttaagg gttgtgagac ctagatgttt cttaccaaag aactccggtg 289680 acttttcttt gcagatttta aatagcaaac tattttatgg tggctttaag ccttccagag 289740 caagcagatt aggtatgtag ttccttttaa taaaagtatt tggaagttca ataaaggcaa 289800 ttatgatttt tctaggacct tttccaattc tgtgattatg tgaatgacta cccggaattt 289860 ccatcaaaca ctgatataca acttgctatg gctacaattt attttggtgt gaaaacatgt 289920 ttgcttttct gttcttatgt ctcccttcat acaaaagtat aatatcccag atatgtaggc 289980 atatagttct gccattcaga gtaattctaa tatactttaa tcttattaac tatctggaag 290040 actaatgcac agttatagct gcatttcttt aagcaagtct atcatatctt tgggtttatg 290100 ccaaactaaa tttgtgaact attatccatt tacaaaatga ttatttacat caatcttcct 290160 ttaaataaca aatgctcaca atgcatttta aaatattacc tactttataa aaatccattc 290220 tgaataaaaa tgggagaata cctgtagtgt tcattgcatt gagttgttga ctctttggcc 290280 aatatgcgtt tatattttgt cttgaaagat ggaccctata ttgacaacat cagttccagt 290340 gtactcattg aaagtggata aggaatatga agtgcgtgtg agatccaaac aacgaaactc 290400 tggaaattat ggcgagttca gtgaggtgct ctatgtaaca cttcctcaga tgagccaatt 290460 tacatgtgaa gaaggtaaaa gaaataaaag attaaaatag tagctaacct ggcttttgtc 290520 aatataacag ttgattcacc cctgcactgg tagtgtgttg tccaaatcaa aatatattaa 290580 catcagatat caggatgaga gaccttgagc tcactatctg taacagatat tgttcattgc 290640 aaaagcagaa ggaagattta gtttccaaat ttttcattca ggagaagtcc ggggggcagg 290700 tggaagttta gagacaggaa tttggtggca atctccggat ggtagaattc agatgattct 290760 tttctttata tatttttata tttctgaaat tttctatagt aagtttgttt tgaatttata 290820 atcaggaaaa aaagctgtac tgatggttag ggaagaaagt atgtatctat atggatggat 290880 agatatgtga catctaagag gaaacccaat attgagtcag cataggtagt caacagcagg 290940 tgcatacggt tttagaaagc ggaggtgtgg cttttaccta gaggaatgcc taataagtag 291000 tgtggcagtc atacttaaag gagacgtgga acatttgaaa accctatgta ggagaatcac 291060 aacaatgatt aaagttttta aaaatgggac ctatgaattt agaataaaag aattaaaact 291120 tttagataca gaaataaaga aaactgatta atgatgagca gaaagtatag agtattatta 291180 ttctcaaatg ggaaatggct ctattccatc ttcattgaaa acagaagttt acagggctat 291240 atgtttgtta atgaaacaac cacaagctac atagaaaata aatttatatt tctgtattta 291300 ctatacaggt agaatctcat gatactaaat agcattagga tgaaaatttc tatagcacca 291360 ttttctctat actctagtta actgaattct tgtttccaaa ctatttgata ttatgcaatt 291420 ctggccttaa aagtacaata gctatacacc cttaagctta gtgtagtggc atttaattca 291480 cttaacatat attttttaaa ctgccttttc cttctgttac taacaaaaaa gaagctctaa 291540 ctttatgtta ttttcctgaa tatgtcattg atatgaaatt atagacacta caagacaaaa 291600 aatgattttt tctcccccac caattcttta aaatgcttat aatatctccc taggggattt 291660 taataacttt ttaaataaga aaagactatt tcagcataaa gacctacatt ttaaatggca 291720 atgttaaggt aaatttcatc tgtcattttt ataaaaaagt ggttagcctc tgcctctgtg 291780 gtaagaatac tgggtaccaa ctgcaaagta gctggcaggt actcaatctt aaggaatgaa 291840 atagaagttt tacaaacagg ttcccccaag tctcatacaa agtatactaa aacctgaaga 291900 tgggagcctc agtagtgatc tttctgtcaa ttttatgtat ataatataca tgagatatat 291960 ttattatatt ttaataattt aatttattga tataaatacg tatatttata gctgtaaaat 292020 atatgttatt tgtgtctaag aagtttctgt catgatttat caataaaaac tctgccttca 292080 tctttttgat aaatcttcaa tctggaaact aagaaaatca ccacacttaa aaaaaaatag 292140 aaaagaaacc gagtgggcat tatttaggta gtgtgttaat aagcaacact tttttactga 292200 agctgaaacc tttatgatac tccctggaca catagtatgc ttaaagcaga ttgtttgttt 292260 tcataaaaca cacattgatt ttgaactata tgctgtttct ttattttgaa gttttttttt 292320 aatgtgagga gatttgaaaa gtggacagag atgttcataa aacagaaaaa aactaagtcg 292380 ttgcattctg tttcagtggt tatcaagaga aatcactgac tttattagat gaatacaaat 292440 tatgaatttt ttgtgaaaag ggaaagggaa atgtaaactg tgcttcaact attcgtaatt 292500 ctgaaagcga aatattcttg tgtgtttcag atttctactt tccatggctc ttaattatta 292560 tctttggaat atttgggcta acagtgatgc tatttgtatt cttattttct aaacagcaaa 292620 ggtaggtgtg gagtagtatt ctttggtatt ttgtaccagt tgtttagatt tccatatgtg 292680 tttctatttg ttatttgata ttttctttgt caaattatga gtggaaattt tagttaacct 292740 agtacacttt tatctccagt tatatattta ccattcatat aaaactcaat ttgttgtatt 292800 tatcttagac aatttagagg tttagattct atctggagac ttgtacagga cattaagagg 292860 cttaggctgg tgactatgca taccttgtga tatgtacctc tttatccaag agctagctct 292920 ttccctcaag tcctcaacaa gttgacccat tcattccagg acttcaaagt atcactgagc 292980 ctttggctga gtctgataca gtccttatat acagacaatt tttttttttc cttgagacgg 293040 agtcttactc tgttgcccag gctggagtgc aatggcgcaa tcttggctca ctgcaaccgc 293100 cgccccccag gttcaagcaa ttctcctgcc tcagcctcca gagtagctgg gattacaggc 293160 atgcgccacc aagcccagct aattttgtat ttttagatac agtttcacca tgttggtcag 293220 actggtctcg aactcctgac ctcaggtgat ctgcccacct cagcctccca aagcgctggg 293280 attacaggcg tgagctaccg cgcctggccc catttaaggt atttttaaag tcccaatggt 293340 taatcttgtt gcttctccta gaattaaggt gactaacact cccaggttgc ctagaactct 293400 cctggttttt agcaatgcaa gtccggtgtg ccaggaaatc cctcagttcc aggtaaccaa 293460 gacagttgat ccccttacct agaattgaaa atacgttctc cagctgaagc caagaggcat 293520 ctataaatca aaatgagatc tatgttaata tattttaaaa gattttactt tgttttgtaa 293580 ggtagtatag cacttgtaaa cttcaaaaca gaattttgtt aggaagaaga attattggga 293640 cgctagattt ctatagtgtc aagcatgcta aaagtctaac tgaatgcaga aagggttatt 293700 ttcagtagag cttcatgtcc aattttataa tataaaccaa ttggaaagta aaattcattc 293760 tgaattccat tttgcaccta actttctggc aacattcctg ttttccaaaa aagcagctat 293820 cataaatcac aacacaattt tctattgttt caggaaaata aataaatata tttttagaat 293880 tttaatttgt gtatttaagt aatgccaaca acaaaaaagc caaattattc tgttgattaa 293940 tttcagttta ttaatctata tatttggtgg gaaaatttat acataacttc agtagataaa 294000 ctcacgaggt atgtaaagta attagctctt agtattagct gtgaatttct agccattgtg 294060 aaggccaagt caatttgtta tgttgtttag ttatattagt taacaatatt aggaagaaaa 294120 aattatcctc tcaaaaagta ggatttccaa gaaaacatat tacttctaat acagtgcttt 294180 ttataaataa tgaaatgctt aactataatg tttagtcaaa atcaccaaat tctacaattg 294240 atttgaaatc tttattgttc tcccaaattt cctgcactaa attgaatttt ctgtaggaaa 294300 gaattaactt tattttttat ttgcccatta aaaacgctta tcattgtcta aatttgcatg 294360 ttctactgaa agtgggaaat agtagcaaat atttgtcagc aagtatggac agaacatgta 294420 gttccaacaa ttaaattgat actgcaaaga acgagatttt tcctagaact gtagggctgt 294480 aaagtggcgt caggtcctac atgcctttga aattttctga gtccacaatt cattatccaa 294540 cccacttcac cctgctttaa tccagttaat tgagtcaact ctagcaaaat ttataatttt 294600 atttgtatct gatacaaaac cacaaacata gtttcaagtc aggctattat tatactggtt 294660 cctaccacac aaccctccca gcctttgagc tgttaccaat tgaggaaaga aataactgaa 294720 tcagcctaaa atagaatttc caaaccagta gcgaaattca gcctacagat tcatattttg 294780 ttattttatt ttaattagtt ttgatttcag agtgaagatt ttcctacaaa gtgtttgtaa 294840 aatagagaat tttcacacaa aaatccagat ttggggatta tcttttaaaa aatgaaagat 294900 gtagtgaaac taaacaaggc agcatatgct gcagcagaca accagctatc ctatttggga 294960 ttggctcaca ttctttaatt tgccaccatc ctcattcctc ctaatgactt tgcaactggc 295020 ttgctttatt cctctgcatg acctgcttgg gcctcttaga tttatgctct gccactgtgg 295080 cataaggtca ctacaaccac tagaaaacca ctagcgcatg cctgaatgca tcatcctatt 295140 taaaaaggaa aagcacacgt cacaaagtca aacatcagcc atttggaaac ctttgcttcc 295200 tgtaattaga attatgttcc atctttttat gtttttggga atttgaaata ccaatttcga 295260 gatgcagaat caaaaaaaaa aaaacaaaac agcgaaacag cagcatgaca caaagaacct 295320 gggttttgat ttggagtcag gttctctggg tttgagcccc aactgtgcca actatgaatg 295380 catgatttga acatgttgct taattttcca agtttttgca cagatatatc atctgcctcc 295440 ctgggagtca taaggattaa gtgaaatgtt tagtgcaggg gtcacaaact tatttcatag 295500 agttagagta catttttagg cttttcaagc catacagtct ctatcacagc tactcaactc 295560 tgccactgta gcacgaaagt ggccataaac aaaatggaaa tgaatgaaga tgcttgtgtt 295620 ctcataaaat tttatctaca caaacatgtg acaggccaga tttggcccac agaccttaat 295680 ttagtgaccc atagtttagt gcaaagtata tcccacagtg tctgatttat cagaagcact 295740 aaaaaatgat agtagttatt attaataatt tgtattactt atttctatat ctgtaattca 295800 tcagtaacaa tatgctttaa catttgcccc actgagtagt agaggctact taatgcaatt 295860 tataaaatgg atttttgctt attacttgga ttaggtaaaa tagcaagtgg aaatactgag 295920 aaaatgtact ccttatggaa tggactggac tgaccattca cactgagtgg aatagtaact 295980 gatatccaaa aatctggtta ccacctcttc atgacagtgt catctctgaa tagtcaggag 296040 ttttttaaaa aattaaatga attgtttgga ataatctctg agcctttttc cagtgctata 296100 atttgatttt aaaaaataaa ctccaggcca gatacaatgg cttatagcat ataaatccag 296160 cactttggga ggatggggcg ggagtattgc cctgaggcca ggagttccag acagctcggg 296220 caatgactag agcaagactc cattacaaaa aatgaaacaa caaaaattag cacaccctgt 296280 agtcctagct acttaggagg ctgaggcaag aatatcgctt ggcccaggag tttgaggctg 296340 cagtgaatta tgattgcacc actggactcc agtgtgggca atgaagtaag accctgtctc 296400 aaaaagtttt aaaaaaaatt aaaaacacca taaattccaa ttacactatt aattgtacaa 296460 aatagataca tgatttattc atttttatga ccaaaaaata atttaaagat ttggaacaaa 296520 aaatgtaagt gcatcctaga attgtatata taaacccata ctgattagtt agagatagtt 296580 aaaatttaat ctgtcccatc tgaaatgaac cctgtagtaa aaccctggtt aataagatca 296640 tcttagataa tttcataatt aatatgaact atatggctaa cctacccaag tctacccttt 296700 ttcaagggtg taagtaatct tggctccatg tggattgact cttttttctt tctttcctgt 296760 acaaattact gatgagatgt acactagaat tgccttatag ctgaaatgga aatcagcttt 296820 agatgaaatt aaatttcttt ctttcaaata ctaaatctgg ctgaaaataa aaagcattaa 296880 gaaaaaaaca attgtgggaa aaccacattt tcttttaata gacttcagat gaggcttttt 296940 gggtttttta gttgttcttt tttttccttc tacagttttt ctttctcatt tactgtctaa 297000 tattttcttc tgtttctcac actccaatta tataaagtac cagaatattt ggaaaaagta 297060 atagtattgc caatatttta tttctatctt ttgctataat tgagaatatg tagcttttaa 297120 gatgtcaaaa ccaaaatttt atatgttttc aaggattaaa atgctgattc tgcccccagt 297180 tccagttcca aagattaaag gaatcgatcc agatctcctc aaggtaacta ataattttat 297240 ctaaattgta gctagtacta attaacacct gaagactcct gtcatatgtt gaaggttttc 297300 tgtaagctat atatatcaca ttcaattttc ttgtgtctct tctcctggag aaaatttttt 297360 taaatattct atttcttaaa aataagaaaa cgtcatatgt atttaaaaag ttacacacta 297420 atttatgttt ttttatatgt tttgttactg ttgttcttat tgtaaccata attaatctct 297480 gaacattatt tgctaattca tttaattatt atgagtttct tttcatagat cttcattttc 297540 tttctatttt ctaggaagga aaattagagg aggtgaacac aatcttagcc attcatgata 297600 gctataaacc cgaattccac agtgatgact cttgggttga atttattgag ctagatattg 297660 atgagccaga tgaaaagact gaggaatcag acacagacag acttctaagc agtgaccatg 297720 agaaatcaca tagtaaccta ggggtgaagg atggcgactc tggacgtacc agctgttgtg 297780 aacctgacat tctggagact gatttcaatg ccaatgacat acatgagggt acctcagagg 297840 ttgctcagcc acagaggtta aaaggggaag cagatctctt atgccttgac cagaagaatc 297900 aaaataactc accttatcat gatgcttgcc ctgctactca gcagcccagt gttatccaag 297960 cagagaaaaa caaaccacaa ccacttccta ctgaaggagc tgagtcaact caccaagctg 298020 cccatattca gctaagcaat ccaagttcac tgtcaaacat cgacttttat gcccaggtga 298080 gcgacattac accagcaggt agtgtggtcc tttccccggg ccaaaagaat aaggcaggga 298140 tgtcccaatg tgacatgcac ccggaaatgg tctcactctg ccaagaaaac ttccttatgg 298200 acaatgccta cttctgtgag gcagatgcca aaaagtgcat ccctgtggct cctcacatca 298260 aggttgaatc acacatacag ccaagcttaa accaagagga catttacatc accacagaaa 298320 gccttaccac tgctgctggg aggcctggga caggagaaca tgttccaggt tctgagatgc 298380 ctgtcccaga ctatacctcc attcatatag tacagtcccc acagggcctc atactcaatg 298440 cgactgcctt gcccttgcct gacaaagagt ttctctcatc atgtggctat gtgagcacag 298500 accaactgaa caaaatcatg ccttagcctt tctttggttt cccaagagct acgtatttaa 298560 tagcaaagaa ttgactgggg caataacgtt taagccaaaa caatgtttaa accttttttg 298620 ggggagtgac aggatggggt atggattcta aaatgccttt tcccaaaatg ttgaaatatg 298680 atgttaaaaa aataagaaga atgcttaatc agatagatat tcctattgtg caatgtaaat 298740 attttaaaga attgtgtcag actgtttagt agcagtgatt gtcttaatat tgtgggtgtt 298800 aatttttgat actaagcatt gaatggctat gtttttaatg tatagtaaat cacgcttttt 298860 gaaaaagcga aaaaatcagg tggcttttgc ggttcaggaa aattgaatgc aaaccatagc 298920 acaggctaat tttttgttgt ttcttaaata agaaactttt ttatttaaaa aactaaaaac 298980 tagaggtgag aaatttaaac tataagcaag aaggcaaaaa tagtttggat atgtaaaaca 299040 tttattttga cataaagttg ataaagattt tttaataatt tagacttcaa gcatggctat 299100 tttatattac actacacact gtgtactgca gttggtatga cccctctaag gagtgtagca 299160 actacagtct aaagctggtt taatgttttg gccaatgcac ctaaagaaaa acaaactcgt 299220 tttttacaaa gcccttttat acctccccag actccttcaa caattctaaa atgattgtag 299280 taatctgcat tattggaata taattgtttt atctgaattt ttaaacaagt atttgttaat 299340 ttagaaaact ttaaagcgtt tgcacagatc aacttaccag gcaccaaaag aagtaaaagc 299400 aaaaaagaaa acctttcttc accaaatctt ggttgatgcc aaaaaaaaat acatgctaag 299460 agaagtagaa atcatagctg gttcacactg accaagatac ttaagtgctg caattgcacg 299520 cggagtgagt tttttagtgc gtgcagatgg tgagagataa gatctatagc ctctgcagcg 299580 gaatctgttc acacccaact tggttttgct acataattat ccaggaaggg aataaggtac 299640 aagaagcatt ttgtaagttg aagcaaatcg aatgaaatta actgggtaat gaaacaaaga 299700 gttcaagaaa taagtttttg tttcacagcc tataaccaga cacatactca tttttcatga 299760 taatgaacag aacatagaca gaagaaacaa ggttttcagt ccccacagat aactgaaaat 299820 tatttaaacc gctaaaagaa actttctttc tcactaaatc ttttatagga tttatttaaa 299880 atagcaaaag aagaagtttc atcatttttt acttcctctc tgagtggact ggcctcaaag 299940 caagcattca gaagaaaaag aagcaacctc agtaatttag aaatcatttt gcaatccctt 300000 aatatcctaa acatcattca tttttgttgt tgttgttgtt gttgagacag agtctcgctc 300060 tgtcgccagg ctagagtgcg gtggcgcgat cttgactcac tgcaatctcc acctcccaca 300120 ggttcaggcg attcccgtgc ctcagcctcc tgagtagctg ggactacagg cacgcaccac 300180 catgccaggc taattttttt gtattttagc agagacgggg tttcaccatg ttggccagga 300240 tggtctcgat ctcctgacct cgtgatccac ccgactcggc ctcccaaagt gctgggatta 300300 caggtgtaag ccaccgtgcc cagccctaaa catcattctt gagagcattg ggatatctcc 300360 tgaaaaggtt tatgaaaaag aagaatctca tctcagtgaa gaatacttct cattttttaa 300420 aaaagcttaa aactttgaag ttagctttaa cttaaatagt atttcccatt tatcgcagac 300480 cttttttagg aagcaagctt aatggctgat aattttaaat tctctctctt gcaggaagga 300540 ctatgaaaag ctagaattga gtgtttaaag ttcaacatgt tatttgtaat agatgtttga 300600 tagattttct gctactttgc tgctatggtt ttctccaaga gctacataat ttagtttcat 300660 ataaagtatc atcagtgtag aacctaattc aattcaaagc tgtgtgtttg gaagactatc 300720 ttactatttc acaacagcct gacaacattt ctatagccaa aaatagctaa atacctcaat 300780 cagtctcaga atgtcatttt ggtactttgg tggccacata agccattatt cactagtatg 300840 actagttgtg tctggcagtt tatatttaac tctctttatg tctgtggatt ttttccttca 300900 aagtttaata aatttatttt cttggattcc tgatagtgtg cttctgttat caaacaccaa 300960 cataaaaatg atctaaacca ctctgtatac tgtgaattat cattgtaagg agagcttagc 301020 accactggat caaatacatc agcattgggt atggagattt ttatgtgctg agatatagag 301080 agggaaacat atcccccttc ccttattttt tgagaagaca aaagcccaac tcagaaatat 301140 cccactggct tggccctccc cttaggctgt gactccccat aggcaaaggt tcatagagct 301200 gtgtatttga tgcatcatgg aaaataaatg acatgggtgt tggatgaggg agagtgatat 301260 gtgagcatta tctttacatt tccagcttga gcatgttgtc tggaaggaag gaaagcagct 301320 cttcctctgc cattcaccca ttggcctaag tcagtttatt ggactagctg cttgttatca 301380 tgggaatcag ctaataagtc aggcttggga ggaaggctga ttaggtaagt tgtgtaggag 301440 cctgagagag ccatgaagtt tagattccta cagcaggagg caggatgcag gtgaggtagc 301500 tgctgaaccc taggctcctg agcaggcact ggattctgag atgtaggaat ctggtgagga 301560 cattgataaa cctactaaac aatgacgtat tgcttcagca agtcaaatgc aaagtgccac 301620 aactttttat aatactcaag tgttatgtta aaaaaaaaaa atgtcttcac ctgctgccct 301680 ctgccctgtg agcagccatt acctgaaaga accatggagt gaagcctcag ggcttcttca 301740 tatagatgct ttaagatatg aggagtacag ggaaaagaaa gcctgcctac ttccatggat 301800 tgaaataaca caattctatt tcagaagatt aatggtgtgt tgaaaatggc tacacacatc 301860 tttcagcatt tcaatttctc aaagtttcta ctaacacttt attcaagtgc tataatattt 301920 acatatttac atatttgtat accaaaatat gtcttgttat gtgcttgttt tagggtaaga 301980 aatagtgacc agaaaaacca gaagttactt aaatctaaac tttttagttt ggaatccaag 302040 atcccacata atttgcccca gtctcctttg agagtttaaa atttaagacc tagatgtaaa 302100 gggcacagct tctgaataag aatttgatgt ttggttaaca ttcaaactct attgctgtgg 302160 aaatctaatg agcatatgat gtcagctatg ttacacggga aacattgctc atagtttaaa 302220 tgatctctga ctgataaatg acatctggat agggagaaac tataaccacc tggagataag 302280 ttatactttg gacttgagtg tagtgacttg taattaagca tttcccctat agaaactctg 302340 gaagctatgt ttctggagat gtaacaagag taactggctc cagtgaggca tagagcttct 302400 aagcctggga gactccttta cctgcccaat accttctctg aatctgagct gccagttgta 302460 ggaggagagg aaggaaaaga ccttctggat agctatataa acagctgttt agattgcttc 302520 atgcactgtt atcattactg tgactctaaa gcagaaagcc tgatgctgta tcccttctgt 302580 cctacatccc tctgagtaga ctggaaccaa gtatggtgaa tctggggaat gtgtggttga 302640 gcctaagaag atccccttgc atatgtagca aaagacactt gccatttctt gaacaaagtt 302700 tgtgctttcc catctctatg ttcttggtca tgcctcctcc ttcaactaaa aagctcccac 302760 ttaccaaccc tgcctgtcaa gattcccttc atccttcatg gcccagctct aatgcctcct 302820 tcatgaactc tcctctgatt cccaccatcc aatcagtgat tttttcttct gaaccatgtt 302880 taatggtgtt tatcacatta ctttggtagc tcacctgaca aacggctagt atagatttac 302940 cagtatgtac gctggtgaat atctatctcc aaaatgccct tgaatggata attttgtggt 303000 <210> 3 <211> 4414 <212> DNA <213> Homo sapien <400> 3 ccgcgctctc tgatcagagg cgaagctcgg aggtcctaca ggtatggatc tctggcagct 60 gctgttgacc ttggcactgg caggatcaag tgatgctttt tctggaagtg aggccacagc 120 agctatcctt agcagagcac cctggagtct gcaaagtgtt aatccaggcc taaagacaaa 180 ttcttctaag gagcctaaat tcaccaagtg ccgttcacct gagcgagaga ctttttcatg 240 ccactggaca gatgaggttc atcatggtac aaagaaccta ggacccatac agctgttcta 300 taccagaagg aacactcaag aatggactca agaatggaaa gaatgccctg attatgtttc 360 tgctggggaa aacagctgtt actttaattc atcgtttacc tccatctgga taccttattg 420 tatcaagcta actagcaatg gtggtacagt ggatgaaaag tgtttctctg ttgatgaaat 480 agtgcaacca gatccaccca ttgccctcaa ctggacttta ctgaacgtca gtttaactgg 540 gattcatgca gatatccaag tgagatggga agcaccacgc aatgcagata ttcagaaagg 600 atggatggtt ctggagtatg aacttcaata caaagaagta aatgaaacta aatggaaaat 660 gatggaccct atattgacaa catcagttcc agtgtactca ttgaaagtgg ataaggaata 720 tgaagtgcgt gtgagatcca aacaacgaaa ctctggaaat tatggcgagt tcagtgaggt 780 gctctatgta acacttcctc agatgagcca atttacatgt gaagaagatt tctactttcc 840 atggctctta attattatct ttggaatatt tgggctaaca gtgatgctat ttgtattctt 900 attttctaaa cagcaaagga ttaaaatgct gattctgccc ccagttccag ttccaaagat 960 taaaggaatc gatccagatc tcctcaagga aggaaaatta gaggaggtga acacaatctt 1020 agccattcat gatagctata aacccgaatt ccacagtgat gactcttggg ttgaatttat 1080 tgagctagat attgatgagc cagatgaaaa gactgaggaa tcagacacag acagacttct 1140 aagcagtgac catgagaaat cacatagtaa cctaggggtg aaggatggcg actctggacg 1200 taccagctgt tgtgaacctg acattctgga gactgatttc aatgccaatg acatacatga 1260 gggtacctca gaggttgctc agccacagag gttaaaaggg gaagcagatc tcttatgcct 1320 tgaccagaag aatcaaaata actcacctta tcatgatgct tgccctgcta ctcagcagcc 1380 cagtgttatc caagcagaga aaaacaaacc acaaccactt cctactgaag gagctgagtc 1440 aactcaccaa gctgcccata ttcagctaag caatccaagt tcactgtcaa acatcgactt 1500 ttatgcccag gtgagcgaca ttacaccagc aggtagtgtg gtcctttccc cgggccaaaa 1560 gaataaggca gggatgtccc aatgtgacat gcacccggaa atggtctcac tctgccaaga 1620 aaacttcctt atggacaatg cctacttctg tgaggcagat gccaaaaagt gcatccctgt 1680 ggctcctcac atcaaggttg aatcacacat acagccaagc ttaaaccaag aggacattta 1740 catcaccaca gaaagcctta ccactgctgc tgggaggcct gggacaggag aacatgttcc 1800 aggttctgag atgcctgtcc cagactatac ctccattcat atagtacagt ccccacaggg 1860 cctcatactc aatgcgactg ccttgccctt gcctgacaaa gagtttctct catcatgtgg 1920 ctatgtgagc acagaccaac tgaacaaaat catgccttag cctttctttg gtttcccaag 1980 agctacgtat ttaatagcaa agaattgact ggggcaataa cgtttaagcc aaaacaatgt 2040 ttaaaccttt tttgggggag tgacaggatg gggtatggat tctaaaatgc cttttcccaa 2100 aatgttgaaa tatgatgtta aaaaaataag aagaatgctt aatcagatag atattcctat 2160 tgtgcaatgt aaatatttta aagaattgtg tcagactgtt tagtagcagt gattgtctta 2220 atattgtggg tgttaatttt tgatactaag cattgaatgg ctatgttttt aatgtatagt 2280 aaatcacgct ttttgaaaaa gcgaaaaaat caggtggctt ttgcggttca ggaaaattga 2340 atgcaaacca tagcacaggc taattttttg ttgtttctta aataagaaac ttttttattt 2400 aaaaaactaa aaactagagg tgagaaattt aaactataag caagaaggca aaaatagttt 2460 ggatatgtaa aacatttact ttgacataaa gttgataaag attttttaat aatttagact 2520 tcaagcatgg ctattttata ttacactaca cactgtgtac tgcagttggt atgacccctc 2580 taaggagtgt agcaactaca gtctaaagct ggtttaatgt tttggccaat gcacctaaag 2640 aaaaacaaac tcgtttttta caaagccctt ttatacctcc ccagactcct tcaacaattc 2700 taaaatgatt gtagtaatct gcattattgg aatataattg ttttatctga atttttaaac 2760 aagtatttgt taatttagaa aactttaaag cgtttgcaca gatcaactta ccaggcacca 2820 aaagaagtaa aagcaaaaaa gaaaaccttt cttcaccaaa tcttggttga tgccaaaaaa 2880 aaatacatgc taagagaagt agaaatcata gctggttcac actgaccaag atacttaagt 2940 gctgcaattg cacgcggagt gagtttttta gtgcgtgcag atggtgagag ataagatcta 3000 tagcctctgc agcggaatct gttcacaccc aacttggttt tgctacataa ttatccagga 3060 agggaataag gtacaagaag cattttgtaa gttgaagcaa atcgaatgaa attaactggg 3120 taatgaaaca aagagttcaa gaaataagtt tttgtttcac agcctataac cagacacata 3180 ctcatttttc atgataatga acagaacata gacagaagaa acaaggtttt cagtccccac 3240 agataactga aaattattta aaccgctaaa agaaactttc tttctcacta aatcttttat 3300 aggatttatt taaaatagca aaagaagaag tttcatcatt ttttacttcc tctctgagtg 3360 gactggcctc aaagcaagca ttcagaagaa aaagaagcaa cctcagtaat ttagaaatca 3420 ttttgcaatc ccttaatatc ctaaacatca ttcatttttg ttgttgttgt tgttgttgag 3480 acagagtctc gctctgtcgc caggctagag tgcggtggcg cgatcttgac tcactgcaat 3540 ctccacctcc cacaggttca ggcgattccc gtgcctcagc ctcctgagta gctgggacta 3600 caggcacgca ccaccatgcc aggctaattt ttttgtattt tagcagagac ggggtttcac 3660 catgttggcc aggatggtct cgagtctcct gacctcgtga tccacccgac tcggcctccc 3720 aaagtgctgg gattacaggt gtaagccacc gtgcccagcc ctaaacatca ttcttgagag 3780 cattgggata tctcctgaaa aggtttatga aaaagaagaa tctcatctca gtgaagaata 3840 cttctcattt tttaaaaaag cttaaaactt tgaagttagc tttaacttaa atagtatttc 3900 ccatttatcg cagacctttt ttaggaagca agcttaatgg ctgataattt taaattctct 3960 ctcttgcagg aaggactatg aaaagctaga attgagtgtt taaagttcaa catgttattt 4020 gtaatagatg tttgatagat tttctgctac tttgctgcta tggttttctc caagagctac 4080 ataatttagt ttcatataaa gtatcatcag tgtagaacct aattcaattc aaagctgtgt 4140 gtttggaaga ctatcttact atttcacaac agcctgacaa catttctata gccaaaaata 4200 gctaaatacc tcaatcagtc tcagaatgtc attttggtac tttggtggcc acataagcca 4260 ttattcacta gtatgactag ttgtgtctgg cagtttatat ttaactctct ttatgtctgt 4320 ggattttttc cttcaaagtt taataaattt attttcttgg attcctgata atgtgcttct 4380 gttatcaaac accaacataa aaatgatcta aacc 4414 <210> 4 <211> 459 <212> DNA <213> Homo sapien <220> <221> misc_feature <222> (342)..(342) <223> n is a, c, g, or t <400> 4 tgtaatacga ctactatagg gcggccgcga attcggcacg agcggcggcg gcggcagcgg 60 cagcagcggc tgctacagtg gcggtggcgg cggcggctgc tgctgagccc gggcggcggc 120 ggggaccccg ggctggggcc acgcgggccg gaggccccgg caccattggc cccagcgcag 180 acgcgaaccc gcgctctctg atcagaggcg aagctcggag gtcctacagg tatggatctc 240 tggcagctgc tgttgacctt ggcactggca ggatcaagtg atgctttttc tggaagtgag 300 gccacagcag ctatccttag cagagcaccc tggagtctgc anagtgttaa tccaggccta 360 aagacaaatt cttctaagga gcctaaattc accaagtgcc gttcacctga gcgagagaac 420 ttttcatgcc actggacaga tgaagttcat catggtaca 459 <210> 5 <211> 569 <212> DNA <213> Homo sapien <220> <221> misc_feature <222> (148)..(148) <223> n is a, c, g, or t <400> 5 gttttgtgcg ggccgcagcc gcacgttggc accgatggaa ctggggtcag tagagtgaca 60 gccaccagtc cgcatgaact ggggtcctac aggtatggat ctctggcagc tgctgttgac 120 cttggcactg gcaggatcaa gtgatgcntt tttctggaag tgaggccaca gcagctatcc 180 ttagcagagc accctggagt ctgcaaagtg ttaatccagg cctaaagaca agatggggtc 240 catgctcaca tatcaagaaa atggagtctt acatgcaagc ctaatgcaga gtagagaagc 300 tcaccaactt gaaggaagca tgaatgaaat tacaaggaaa tctagcttag aaaaattaac 360 cctgtagctt ggtttttcca ctctttgctc ttggcaaaag gatcttacgg gaaaactgga 420 gcttagagaa cttatgtaac attactagca agttgcacag ctgggattca aactgaaatc 480 cagctagctt caaagactgt gttctttctg ctgctgcata ctacccctac ctaccaaggc 540 tctgagatta gaaagcagga tgggtgtgt 569 <210> 6 <211> 421 <212> DNA <213> Homo sapien <400> 6 gcgcgtgaac acagcgcgca gagcgcgcgg tcttttgcgc gtttgtgcgg gccgcagccg 60 cacgttggca ccgatggaac tggggtcagt agagtgacag ccaccagtcc gcatgaactg 120 ggttaaaatg agcaacttct ttaaccagaa ctgaccttga agacaaatgg ctaaaataaa 180 acatttgctg aattcactgg gcgcatctta caagtaattt ttggattctg cattgactac 240 ctacaagtgc cttctgggtg caagtccaca ggcaagattt gttctgcaaa tcttccatga 300 ccaaggtcac ctctttggat tggcagaccc agggagtcca tattgggaag ataaattcac 360 acttcacccc ttgttgagat ctccagcctt gctcctctga taaccaggtc ctacaggtat 420 g 421 <210> 7 <211> 434 <212> DNA <213> homo sapien <400> 7 tgagatctcc atccagcctt gctcctctga taaccagttt ttggcatctc agatgaggaa 60 gagtgatggg cgacaggtga tggtgacaac tattaataag atctgaaagt aaacagtctc 120 atgaaaggtg gccaggagag ggcagtcacc ttttatcagg agcacagact gaatttgcaa 180 agggtcctac aggtatggat ctctggcagc tgctgttgac cttggcactg gcaggatcaa 240 gtgatgcttt ttctggaagt gaggctctga aatacctact tccaagagaa cgaaatttat 300 tcaagaaatg ttggatggaa attgaagagt gagcttggaa acgagacaca gagtggcagg 360 agcccagacc aacctgttta tgaaagatgc ctttgcccat agagggaaaa atacacctta 420 aaacctcaaa aaaa 434 <210> 8 <211> 2177 <212> DNA <213> Homo sapien <400> 8 cgaagctcgg aggtcctaca ggtatggatc tctggcagct gctgttgacc ttggcactgg 60 caggatcaag tgatgctttt tctggaagtg aggccacagc agctatcctt agcagagcac 120 cctggagtct gcaaagtgtt aatccaggcc taaagacaag aacactcaag aatggactca 180 agaatggaaa gaatgccctg attatgtttc tgctggggaa aacagctgtt actttaattc 240 atcgtttacc tccatctgga taccttattg tatcaagcta actagcaatg gtggtacagt 300 ggatgaaaag tgtttctctg ttgatgaaat agtgcaacca gatccaccca ttgccctcaa 360 ctggacttta ctgaacgtca gtttaactgg gattcatgca gatatccaag tgagatggga 420 agcaccacgc aatgcagata ttcagaaagg gtggatggtt ctggagtatg aacttcaata 480 caaagaagta aatgaaacta aatggaaaat gatggaccct atattgacaa catcagttcc 540 agtgtactca ttgaaagtgg ataaggaata tgaagtgcgt gtgagatcca aacaacgaaa 600 ctctggaaat tatggcgagt tcagtgaggt gctctatgta acacttcctc agatgagcca 660 atttacatgt gaagaagatt tctactttcc atggctctta attattatct ttggaatatt 720 tgggctaaca gtgatgctat ttgtattctt attttctaaa cagcaaagga ttaaaatgct 780 gattctgccc ccagttccag ttccaaagat taaaggaatc gatccagatc tcctcaagga 840 aggaaaatta gaggaggtga acacaatctt agccattcat gatagctata aacccgaatt 900 ccacagtgat gactcttggg ttgaatttat tgagctagat attgatgagc cagatgaaaa 960 gactgaggaa tcagacacag acagacttct aagcagtgac catgagaaat cacatagtaa 1020 cctaggggtg aaggatggcg actctggacg taccagctgt tgtgaacctg acattctgga 1080 gactgatttc aatgccaatg acatacatga gggtacctca gaggttgctc agccacagag 1140 gttaaaaggg gaagcagatc tcttatgcct tgaccagaag aatcaaaata actcacctta 1200 tcatgatgct tgccctgcta ctcagcagcc cagtgttatc caagcagaga aaaacaaacc 1260 acaaccactt cctactgaag gagctgagtc aactcaccaa gctgcccata ttcagctaag 1320 caatccaagt tcactgtcaa acatcgactt ttatgcccag gtgagcgaca ttacaccagc 1380 aggtagtgtg gtcctttccc cgggccaaaa gaataaggca gggatgtccc aatgtgacat 1440 gcacccggaa atggtctcac tctgccaaga aaacttcctt atggacaatg cctacttctg 1500 tgaggcagat gccaaaaagt gcctccctgt ggctcctcac atcaaggttg aatcacacat 1560 acagccaagc ttaaaccaag aggacattta catcaccaca gaaagcctta ccactgctgc 1620 tgggaggcct gggacaggag aacatgttcc aggttctgag atgcctgtcc cagactatac 1680 ctccattcat atagtacagt ccccacaggg cctcatactc aatgcgactg ccttgccctt 1740 gcctgacaaa gagtttctct catcatgtgg ctatgtgagc acagaccaac tgaacaaaat 1800 catgccttag cctttctttg gtttcccaag agctacgtat ttaatagcaa agaattgact 1860 ggggcaataa cgtttaagcc aaaacaatgt ttaaaccttt tttgggggag tgacaggatg 1920 gggtatggat tctaaaatgc cttttcccaa aatgttgaaa tatgatgtta aaaaaataag 1980 aagaatgctt aatcagatag atattcctat tgtgcaatgt aaatatttta aagaattgtg 2040 tcagactgtt tagtagcagt gattgtctta atattgtggg tgttaatttt tgatactaag 2100 cattgaatga ctatgttttt aatgtatagt aaatcacgct ttttgaaaaa gcgaaaaaat 2160 caggtggctt ttgcggt 2177 <210> 9 <211> 4529 <212> DNA <213> Homo sapien <400> 9 ggagagactg gggaggtcga gctgtgcgcg tggacacagc gcgcagagcg cgcggtcttt 60 tgcgcgtttg tgcgggccgc agccgcacgt tggcaccgat ggaactgggg tcagtagagt 120 gacagccacc agtccgcatg aactggggtc ctacaggtat ggatctctgg cagctgctgt 180 tgaccttggc actggcagga tcaagtgatg ctttttctgg aagtgaggcc acagcagcta 240 tccttagcag agcaccctgg agtctgcaaa gtgttaatcc aggcctaaag acaaattctt 300 ctaaggagcc taaattcacc aagtgccgtt cacctgagcg agagactttt tcatgccact 360 ggacagatga ggttcatcat ggtacaaaga acctaggacc catacagctg ttctatacca 420 gaaggaacac tcaagaatgg actcaagaat ggaaagaatg ccctgattat gtttctgctg 480 gggaaaacag ctgttacttt aattcatcgt ttacctccat ctggatacct tattgtatca 540 agctaactag caatggtggt acagtggatg aaaagtgttt ctctgttgat gaaatagtgc 600 aaccagatcc acccattgcc ctcaactgga ctttactgaa cgtcagttta actgggattc 660 atgcagatat ccaagtgaga tgggaagcac cacgcaatgc agatattcag aaaggatgga 720 tggttctgga gtatgaactt caatacaaag aagtaaatga aactaaatgg aaaatgatgg 780 accctatatt gacaacatca gttccagtgt actcattgaa agtggataag gaatatgaag 840 tgcgtgtgag atccaaacaa cgaaactctg gaaattatgg cgagttcagt gaggtgctct 900 atgtaacact tcctcagatg agccaattta catgtgaaga agatttctac tttccatggc 960 tcttaattat tatctttgga atatttgggc taacagtgat gctatttgta ttcttatttt 1020 ctaaacagca aaggattaaa atgctgattc tgcccccagt tccagttcca aagattaaag 1080 gaatcgatcc agatctcctc aaggaaggaa aattagagga ggtgaacaca atcttagcca 1140 ttcatgatag ctataaaccc gaattccaca gtgatgactc ttgggttgaa tttattgagc 1200 tagatattga tgagccagat gaaaagactg aggaatcaga cacagacaga cttctaagca 1260 gtgaccatga gaaatcacat agtaacctag gggtgaagga tggcgactct ggacgtacca 1320 gctgttgtga acctgacatt ctggagactg atttcaatgc caatgacata catgagggta 1380 cctcagaggt tgctcagcca cagaggttaa aaggggaagc agatctctta tgccttgacc 1440 agaagaatca aaataactca ccttatcatg atgcttgccc tgctactcag cagcccagtg 1500 ttatccaagc agagaaaaac aaaccacaac cacttcctac tgaaggagct gagtcaactc 1560 accaagctgc ccatattcag ctaagcaatc caagttcact gtcaaacatc gacttttatg 1620 cccaggtgag cgacattaca ccagcaggta gtgtggtcct ttccccgggc caaaagaata 1680 aggcagggat gtcccaatgt gacatgcacc cggaaatggt ctcactctgc caagaaaact 1740 tccttatgga caatgcctac ttctgtgagg cagatgccaa aaagtgcatc cctgtggctc 1800 ctcacatcaa ggttgaatca cacatacagc caagcttaaa ccaagaggac atttacatca 1860 ccacagaaag ccttaccact gctgctggga ggcctgggac aggagaacat gttccaggtt 1920 ctgagatgcc tgtcccagac tatacctcca ttcatatagt acagtcccca cagggcctca 1980 tactcaatgc gactgccttg cccttgcctg acaaagagtt tctctcatca tgtggctatg 2040 tgagcacaga ccaactgaac aaaatcatgc cttagccttt ctttggtttc ccaagagcta 2100 cgtatttaat agcaaagaat tgactggggc aataacgttt aagccaaaac aatgtttaaa 2160 ccttttttgg gggagtgaca ggatggggta tggattctaa aatgcctttt cccaaaatgt 2220 tgaaatatga tgttaaaaaa ataagaagaa tgcttaatca gatagatatt cctattgtgc 2280 aatgtaaata ttttaaagaa ttgtgtcaga ctgtttagta gcagtgattg tcttaatatt 2340 gtgggtgtta atttttgata ctaagcattg aatggctatg tttttaatgt atagtaaatc 2400 acgctttttg aaaaagcgaa aaaatcaggt ggcttttgcg gttcaggaaa attgaatgca 2460 aaccatagca caggctaatt ttttgttgtt tcttaaataa gaaacttttt tatttaaaaa 2520 actaaaaact agaggtgaga aatttaaact ataagcaaga aggcaaaaat agtttggata 2580 tgtaaaacat ttattttgac ataaagttga taaagatttt ttaataattt agacttcaag 2640 catggctatt ttatattaca ctacacactg tgtactgcag ttggtatgac ccctctaagg 2700 agtgtagcaa ctacagtcta aagctggttt aatgttttgg ccaatgcacc taaagaaaaa 2760 caaactcgtt ttttacaaag cccttttata cctccccaga ctccttcaac aattctaaaa 2820 tgattgtagt aatctgcatt attggaatat aattgtttta tctgaatttt taaacaagta 2880 tttgttaatt tagaaaactt taaagcgttt gcacagatca acttaccagg caccaaaaga 2940 agtaaaagca aaaaagaaaa cctttcttca ccaaatcttg gttgatgcca aaaaaaaata 3000 catgctaaga gaagtagaaa tcatagctgg ttcacactga ccaagatact taagtgctgc 3060 aattgcacgc ggagtgagtt ttttagtgcg tgcagatggt gagagataag atctatagcc 3120 tctgcagcgg aatctgttca cacccaactt ggttttgcta cataattatc caggaaggga 3180 ataaggtaca agaagcattt tgtaagttga agcaaatcga atgaaattaa ctgggtaatg 3240 aaacaaagag ttcaagaaat aagtttttgt ttcacagcct ataaccagac acatactcat 3300 ttttcatgat aatgaacaga acatagacag aagaaacaag gttttcagtc cccacagata 3360 actgaaaatt atttaaaccg ctaaaagaaa ctttctttct cactaaatct tttataggat 3420 ttatttaaaa tagcaaaaga agaagtttca tcatttttta cttcctctct gagtggactg 3480 gcctcaaagc aagcattcag aagaaaaaga agcaacctca gtaatttaga aatcattttg 3540 caatccctta atatcctaaa catcattcat ttttgttgtt gttgttgttg ttgagacaga 3600 gtctcgctct gtcgccaggc tagagtgcgg tggcgcgatc ttgactcact gcaatctcca 3660 cctcccacag gttcaggcga ttcccgtgcc tcagcctcct gagtagctgg gactacaggc 3720 acgcaccacc atgccaggct aatttttttg tattttagca gagacggggt ttcaccatgt 3780 tggccaggat ggtctcgatc tcctgacctc gtgatccacc cgactcggcc tcccaaagtg 3840 ctgggattac aggtgtaagc caccgtgccc agccctaaac atcattcttg agagcattgg 3900 gatatctcct gaaaaggttt atgaaaaaga agaatctcat ctcagtgaag aatacttctc 3960 attttttaaa aaagcttaaa actttgaagt tagctttaac ttaaatagta tttcccattt 4020 atcgcagacc ttttttagga agcaagctta atggctgata attttaaatt ctctctcttg 4080 caggaaggac tatgaaaagc tagaattgag tgtttaaagt tcaacatgtt atttgtaata 4140 gatgtttgat agattttctg ctactttgct gctatggttt tctccaagag ctacataatt 4200 tagtttcata taaagtatca tcagtgtaga acctaattca attcaaagct gtgtgtttgg 4260 aagactatct tactatttca caacagcctg acaacatttc tatagccaaa aatagctaaa 4320 tacctcaatc agtctcagaa tgtcattttg gtactttggt ggccacataa gccattattc 4380 actagtatga ctagttgtgt ctggcagttt atatttaact ctctttatgt ctgtggattt 4440 tttccttcaa agtttaataa atttattttc ttggattcct gatagtgtgc ttctgttatc 4500 aaacaccaac ataaaaatga tctaaacca 4529 <210> 10 <211> 4814 <212> DNA <213> Homo sapien <400> 10 ggagagactg gggaggtcga gctgtgcgcg tggacacagc gcgcagagcg cgcggtcttt 60 tgcgcgtttg tgcgggccgc agccgcacgt tggcaccgat ggaactgggg tcagtagagt 120 gacagccacc agtccgcatg aactgggtta aaatgagcaa cttctttaac cagaactgac 180 cttgaagaca aatggctaaa ataaaacatt tgctgaattc actgggcgca tcttacaagt 240 aatttttgga ttctgcattg actacctaca agtgccttct gggtgcaagt ccacaggcaa 300 gatttgttct gcaaatcttc catgaccaag gtcacctctt tggattggca gacccaggga 360 gtccatattg ggaagataaa ttcacacttc accccttgtt gagatctcca gccttgctcc 420 tctgataacc aggtcctaca ggtatggatc tctggcagct gctgttgacc ttggcactgg 480 caggatcaag tgatgctttt tctggaagtg aggccacagc agctatcctt agcagagcac 540 cctggagtct gcaaagtgtt aatccaggcc taaagacaaa ttcttctaag gagcctaaat 600 tcaccaagtg ccgttcacct gagcgagaga ctttttcatg ccactggaca gatgaggttc 660 atcatggtac aaagaaccta ggacccatac agctgttcta taccagaagg aacactcaag 720 aatggactca agaatggaaa gaatgccctg attatgtttc tgctggggaa aacagctgtt 780 actttaattc atcgtttacc tccatctgga taccttattg tatcaagcta actagcaatg 840 gtggtacagt ggatgaaaag tgtttctctg ttgatgaaat agtgcaacca gatccaccca 900 ttgccctcaa ctggacttta ctgaacgtca gtttaactgg gattcatgca gatatccaag 960 tgagatggga agcaccacgc aatgcagata ttcagaaagg atggatggtt ctggagtatg 1020 aacttcaata caaagaagta aatgaaacta aatggaaaat gatggaccct atattgacaa 1080 catcagttcc agtgtactca ttgaaagtgg ataaggaata tgaagtgcgt gtgagatcca 1140 aacaacgaaa ctctggaaat tatggcgagt tcagtgaggt gctctatgta acacttcctc 1200 agatgagcca atttacatgt gaagaagatt tctactttcc atggctctta attattatct 1260 ttggaatatt tgggctaaca gtgatgctat ttgtattctt attttctaaa cagcaaagga 1320 ttaaaatgct gattctgccc ccagttccag ttccaaagat taaaggaatc gatccagatc 1380 tcctcaagga aggaaaatta gaggaggtga acacaatctt agccattcat gatagctata 1440 aacccgaatt ccacagtgat gactcttggg ttgaatttat tgagctagat attgatgagc 1500 cagatgaaaa gactgaggaa tcagacacag acagacttct aagcagtgac catgagaaat 1560 cacatagtaa cctaggggtg aaggatggcg actctggacg taccagctgt tgtgaacctg 1620 acattctgga gactgatttc aatgccaatg acatacatga gggtacctca gaggttgctc 1680 agccacagag gttaaaaggg gaagcagatc tcttatgcct tgaccagaag aatcaaaata 1740 actcacctta tcatgatgct tgccctgcta ctcagcagcc cagtgttatc caagcagaga 1800 aaaacaaacc acaaccactt cctactgaag gagctgagtc aactcaccaa gctgcccata 1860 ttcagctaag caatccaagt tcactgtcaa acatcgactt ttatgcccag gtgagcgaca 1920 ttacaccagc aggtagtgtg gtcctttccc cgggccaaaa gaataaggca gggatgtccc 1980 aatgtgacat gcacccggaa atggtctcac tctgccaaga aaacttcctt atggacaatg 2040 cctacttctg tgaggcagat gccaaaaagt gcatccctgt ggctcctcac atcaaggttg 2100 aatcacacat acagccaagc ttaaaccaag aggacattta catcaccaca gaaagcctta 2160 ccactgctgc tgggaggcct gggacaggag aacatgttcc aggttctgag atgcctgtcc 2220 cagactatac ctccattcat atagtacagt ccccacaggg cctcatactc aatgcgactg 2280 ccttgccctt gcctgacaaa gagtttctct catcatgtgg ctatgtgagc acagaccaac 2340 tgaacaaaat catgccttag cctttctttg gtttcccaag agctacgtat ttaatagcaa 2400 agaattgact ggggcaataa cgtttaagcc aaaacaatgt ttaaaccttt tttgggggag 2460 tgacaggatg gggtatggat tctaaaatgc cttttcccaa aatgttgaaa tatgatgtta 2520 aaaaaataag aagaatgctt aatcagatag atattcctat tgtgcaatgt aaatatttta 2580 aagaattgtg tcagactgtt tagtagcagt gattgtctta atattgtggg tgttaatttt 2640 tgatactaag cattgaatgg ctatgttttt aatgtatagt aaatcacgct ttttgaaaaa 2700 gcgaaaaaat caggtggctt ttgcggttca ggaaaattga atgcaaacca tagcacaggc 2760 taattttttg ttgtttctta aataagaaac ttttttattt aaaaaactaa aaactagagg 2820 tgagaaattt aaactataag caagaaggca aaaatagttt ggatatgtaa aacatttatt 2880 ttgacataaa gttgataaag attttttaat aatttagact tcaagcatgg ctattttata 2940 ttacactaca cactgtgtac tgcagttggt atgacccctc taaggagtgt agcaactaca 3000 gtctaaagct ggtttaatgt tttggccaat gcacctaaag aaaaacaaac tcgtttttta 3060 caaagccctt ttatacctcc ccagactcct tcaacaattc taaaatgatt gtagtaatct 3120 gcattattgg aatataattg ttttatctga atttttaaac aagtatttgt taatttagaa 3180 aactttaaag cgtttgcaca gatcaactta ccaggcacca aaagaagtaa aagcaaaaaa 3240 gaaaaccttt cttcaccaaa tcttggttga tgccaaaaaa aaatacatgc taagagaagt 3300 agaaatcata gctggttcac actgaccaag atacttaagt gctgcaattg cacgcggagt 3360 gagtttttta gtgcgtgcag atggtgagag ataagatcta tagcctctgc agcggaatct 3420 gttcacaccc aacttggttt tgctacataa ttatccagga agggaataag gtacaagaag 3480 cattttgtaa gttgaagcaa atcgaatgaa attaactggg taatgaaaca aagagttcaa 3540 gaaataagtt tttgtttcac agcctataac cagacacata ctcatttttc atgataatga 3600 acagaacata gacagaagaa acaaggtttt cagtccccac agataactga aaattattta 3660 aaccgctaaa agaaactttc tttctcacta aatcttttat aggatttatt taaaatagca 3720 aaagaagaag tttcatcatt ttttacttcc tctctgagtg gactggcctc aaagcaagca 3780 ttcagaagaa aaagaagcaa cctcagtaat ttagaaatca ttttgcaatc ccttaatatc 3840 ctaaacatca ttcatttttg ttgttgttgt tgttgttgag acagagtctc gctctgtcgc 3900 caggctagag tgcggtggcg cgatcttgac tcactgcaat ctccacctcc cacaggttca 3960 ggcgattccc gtgcctcagc ctcctgagta gctgggacta caggcacgca ccaccatgcc 4020 aggctaattt ttttgtattt tagcagagac ggggtttcac catgttggcc aggatggtct 4080 cgatctcctg acctcgtgat ccacccgact cggcctccca aagtgctggg attacaggtg 4140 taagccaccg tgcccagccc taaacatcat tcttgagagc attgggatat ctcctgaaaa 4200 ggtttatgaa aaagaagaat ctcatctcag tgaagaatac ttctcatttt ttaaaaaagc 4260 ttaaaacttt gaagttagct ttaacttaaa tagtatttcc catttatcgc agaccttttt 4320 taggaagcaa gcttaatggc tgataatttt aaattctctc tcttgcagga aggactatga 4380 aaagctagaa ttgagtgttt aaagttcaac atgttatttg taatagatgt ttgatagatt 4440 ttctgctact ttgctgctat ggttttctcc aagagctaca taatttagtt tcatataaag 4500 tatcatcagt gtagaaccta attcaattca aagctgtgtg tttggaagac tatcttacta 4560 tttcacaaca gcctgacaac atttctatag ccaaaaatag ctaaatacct caatcagtct 4620 cagaatgtca ttttggtact ttggtggcca cataagccat tattcactag tatgactagt 4680 tgtgtctggc agtttatatt taactctctt tatgtctgtg gattttttcc ttcaaagttt 4740 aataaattta ttttcttgga ttcctgatag tgtgcttctg ttatcaaaca ccaacataaa 4800 aatgatctaa acca 4814 <210> 11 <211> 4522 <212> DNA <213> Homo sapien <400> 11 gcctgtctgt ttgtgccgcc aggagacctt ggaagggaca gagaaagagc tggggttttg 60 ccatgttgcc caggctgatc tccaacacct gggatcaagc agtctgccca ccttggcctc 120 ccaaagtgct gaaattacag gtcctacagg tatggatctc tggcagctgc tgttgacctt 180 ggcactggca ggatcaagtg atgctttttc tggaagtgag gccacagcag ctatccttag 240 cagagcaccc tggagtctgc aaagtgttaa tccaggccta aagacaaatt cttctaagga 300 gcctaaattc accaagtgcc gttcacctga gcgagagact ttttcatgcc actggacaga 360 tgaggttcat catggtacaa agaacctagg acccatacag ctgttctata ccagaaggaa 420 cactcaagaa tggactcaag aatggaaaga atgccctgat tatgtttctg ctggggaaaa 480 cagctgttac tttaattcat cgtttacctc catctggata ccttattgta tcaagctaac 540 tagcaatggt ggtacagtgg atgaaaagtg tttctctgtt gatgaaatag tgcaaccaga 600 tccacccatt gccctcaact ggactttact gaacgtcagt ttaactggga ttcatgcaga 660 tatccaagtg agatgggaag caccacgcaa tgcagatatt cagaaaggat ggatggttct 720 ggagtatgaa cttcaataca aagaagtaaa tgaaactaaa tggaaaatga tggaccctat 780 attgacaaca tcagttccag tgtactcatt gaaagtggat aaggaatatg aagtgcgtgt 840 gagatccaaa caacgaaact ctggaaatta tggcgagttc agtgaggtgc tctatgtaac 900 acttcctcag atgagccaat ttacatgtga agaagatttc tactttccat ggctcttaat 960 tattatcttt ggaatatttg ggctaacagt gatgctattt gtattcttat tttctaaaca 1020 gcaaaggatt aaaatgctga ttctgccccc agttccagtt ccaaagatta aaggaatcga 1080 tccagatctc ctcaaggaag gaaaattaga ggaggtgaac acaatcttag ccattcatga 1140 tagctataaa cccgaattcc acagtgatga ctcttgggtt gaatttattg agctagatat 1200 tgatgagcca gatgaaaaga ctgaggaatc agacacagac agacttctaa gcagtgacca 1260 tgagaaatca catagtaacc taggggtgaa ggatggcgac tctggacgta ccagctgttg 1320 tgaacctgac attctggaga ctgatttcaa tgccaatgac atacatgagg gtacctcaga 1380 ggttgctcag ccacagaggt taaaagggga agcagatctc ttatgccttg accagaagaa 1440 tcaaaataac tcaccttatc atgatgcttg ccctgctact cagcagccca gtgttatcca 1500 agcagagaaa aacaaaccac aaccacttcc tactgaagga gctgagtcaa ctcaccaagc 1560 tgcccatatt cagctaagca atccaagttc actgtcaaac atcgactttt atgcccaggt 1620 gagcgacatt acaccagcag gtagtgtggt cctttccccg ggccaaaaga ataaggcagg 1680 gatgtcccaa tgtgacatgc acccggaaat ggtctcactc tgccaagaaa acttccttat 1740 ggacaatgcc tacttctgtg aggcagatgc caaaaagtgc atccctgtgg ctcctcacat 1800 caaggttgaa tcacacatac agccaagctt aaaccaagag gacatttaca tcaccacaga 1860 aagccttacc actgctgctg ggaggcctgg gacaggagaa catgttccag gttctgagat 1920 gcctgtccca gactatacct ccattcatat agtacagtcc ccacagggcc tcatactcaa 1980 tgcgactgcc ttgcccttgc ctgacaaaga gtttctctca tcatgtggct atgtgagcac 2040 agaccaactg aacaaaatca tgccttagcc tttctttggt ttcccaagag ctacgtattt 2100 aatagcaaag aattgactgg ggcaataacg tttaagccaa aacaatgttt aaaccttttt 2160 tgggggagtg acaggatggg gtatggattc taaaatgcct tttcccaaaa tgttgaaata 2220 tgatgttaaa aaaataagaa gaatgcttaa tcagatagat attcctattg tgcaatgtaa 2280 atattttaaa gaattgtgtc agactgttta gtagcagtga ttgtcttaat attgtgggtg 2340 ttaatttttg atactaagca ttgaatggct atgtttttaa tgtatagtaa atcacgcttt 2400 ttgaaaaagc gaaaaaatca ggtggctttt gcggttcagg aaaattgaat gcaaaccata 2460 gcacaggcta attttttgtt gtttcttaaa taagaaactt ttttatttaa aaaactaaaa 2520 actagaggtg agaaatttaa actataagca agaaggcaaa aatagtttgg atatgtaaaa 2580 catttatttt gacataaagt tgataaagat tttttaataa tttagacttc aagcatggct 2640 attttatatt acactacaca ctgtgtactg cagttggtat gacccctcta aggagtgtag 2700 caactacagt ctaaagctgg tttaatgttt tggccaatgc acctaaagaa aaacaaactc 2760 gttttttaca aagccctttt atacctcccc agactccttc aacaattcta aaatgattgt 2820 agtaatctgc attattggaa tataattgtt ttatctgaat ttttaaacaa gtatttgtta 2880 atttagaaaa ctttaaagcg tttgcacaga tcaacttacc aggcaccaaa agaagtaaaa 2940 gcaaaaaaga aaacctttct tcaccaaatc ttggttgatg ccaaaaaaaa atacatgcta 3000 agagaagtag aaatcatagc tggttcacac tgaccaagat acttaagtgc tgcaattgca 3060 cgcggagtga gttttttagt gcgtgcagat ggtgagagat aagatctata gcctctgcag 3120 cggaatctgt tcacacccaa cttggttttg ctacataatt atccaggaag ggaataaggt 3180 acaagaagca ttttgtaagt tgaagcaaat cgaatgaaat taactgggta atgaaacaaa 3240 gagttcaaga aataagtttt tgtttcacag cctataacca gacacatact catttttcat 3300 gataatgaac agaacataga cagaagaaac aaggttttca gtccccacag ataactgaaa 3360 attatttaaa ccgctaaaag aaactttctt tctcactaaa tcttttatag gatttattta 3420 aaatagcaaa agaagaagtt tcatcatttt ttacttcctc tctgagtgga ctggcctcaa 3480 agcaagcatt cagaagaaaa agaagcaacc tcagtaattt agaaatcatt ttgcaatccc 3540 ttaatatcct aaacatcatt catttttgtt gttgttgttg ttgttgagac agagtctcgc 3600 tctgtcgcca ggctagagtg cggtggcgcg atcttgactc actgcaatct ccacctccca 3660 caggttcagg cgattcccgt gcctcagcct cctgagtagc tgggactaca ggcacgcacc 3720 accatgccag gctaattttt ttgtatttta gcagagacgg ggtttcacca tgttggccag 3780 gatggtctcg atctcctgac ctcgtgatcc acccgactcg gcctcccaaa gtgctgggat 3840 tacaggtgta agccaccgtg cccagcccta aacatcattc ttgagagcat tgggatatct 3900 cctgaaaagg tttatgaaaa agaagaatct catctcagtg aagaatactt ctcatttttt 3960 aaaaaagctt aaaactttga agttagcttt aacttaaata gtatttccca tttatcgcag 4020 acctttttta ggaagcaagc ttaatggctg ataattttaa attctctctc ttgcaggaag 4080 gactatgaaa agctagaatt gagtgtttaa agttcaacat gttatttgta atagatgttt 4140 gatagatttt ctgctacttt gctgctatgg ttttctccaa gagctacata atttagtttc 4200 atataaagta tcatcagtgt agaacctaat tcaattcaaa gctgtgtgtt tggaagacta 4260 tcttactatt tcacaacagc ctgacaacat ttctatagcc aaaaatagct aaatacctca 4320 atcagtctca gaatgtcatt ttggtacttt ggtggccaca taagccatta ttcactagta 4380 tgactagttg tgtctggcag tttatattta actctcttta tgtctgtgga ttttttcctt 4440 caaagtttaa taaatttatt ttcttggatt cctgatagtg tgcttctgtt atcaaacacc 4500 aacataaaaa tgatctaaac ca 4522 <210> 12 <211> 4491 <212> DNA <213> Homo sapien <400> 12 cctcttctca gctgatttgg ctgcctccat tgtaataggc ctcatgagac tccagcctag 60 gcctggcctt cagttcagca ggcagagccc agagatgtac tgggcaaagg tcctacaggt 120 atggatctct ggcagctgct gttgaccttg gcactggcag gatcaagtga tgctttttct 180 ggaagtgagg ccacagcagc tatccttagc agagcaccct ggagtctgca aagtgttaat 240 ccaggcctaa agacaaattc ttctaaggag cctaaattca ccaagtgccg ttcacctgag 300 cgagagactt tttcatgcca ctggacagat gaggttcatc atggtacaaa gaacctagga 360 cccatacagc tgttctatac cagaaggaac actcaagaat ggactcaaga atggaaagaa 420 tgccctgatt atgtttctgc tggggaaaac agctgttact ttaattcatc gtttacctcc 480 atctggatac cttattgtat caagctaact agcaatggtg gtacagtgga tgaaaagtgt 540 ttctctgttg atgaaatagt gcaaccagat ccacccattg ccctcaactg gactttactg 600 aacgtcagtt taactgggat tcatgcagat atccaagtga gatgggaagc accacgcaat 660 gcagatattc agaaaggatg gatggttctg gagtatgaac ttcaatacaa agaagtaaat 720 gaaactaaat ggaaaatgat ggaccctata ttgacaacat cagttccagt gtactcattg 780 aaagtggata aggaatatga agtgcgtgtg agatccaaac aacgaaactc tggaaattat 840 ggcgagttca gtgaggtgct ctatgtaaca cttcctcaga tgagccaatt tacatgtgaa 900 gaagatttct actttccatg gctcttaatt attatctttg gaatatttgg gctaacagtg 960 atgctatttg tattcttatt ttctaaacag caaaggatta aaatgctgat tctgccccca 1020 gttccagttc caaagattaa aggaatcgat ccagatctcc tcaaggaagg aaaattagag 1080 gaggtgaaca caatcttagc cattcatgat agctataaac ccgaattcca cagtgatgac 1140 tcttgggttg aatttattga gctagatatt gatgagccag atgaaaagac tgaggaatca 1200 gacacagaca gacttctaag cagtgaccat gagaaatcac atagtaacct aggggtgaag 1260 gatggcgact ctggacgtac cagctgttgt gaacctgaca ttctggagac tgatttcaat 1320 gccaatgaca tacatgaggg tacctcagag gttgctcagc cacagaggtt aaaaggggaa 1380 gcagatctct tatgccttga ccagaagaat caaaataact caccttatca tgatgcttgc 1440 cctgctactc agcagcccag tgttatccaa gcagagaaaa acaaaccaca accacttcct 1500 actgaaggag ctgagtcaac tcaccaagct gcccatattc agctaagcaa tccaagttca 1560 ctgtcaaaca tcgactttta tgcccaggtg agcgacatta caccagcagg tagtgtggtc 1620 ctttccccgg gccaaaagaa taaggcaggg atgtcccaat gtgacatgca cccggaaatg 1680 gtctcactct gccaagaaaa cttccttatg gacaatgcct acttctgtga ggcagatgcc 1740 aaaaagtgca tccctgtggc tcctcacatc aaggttgaat cacacataca gccaagctta 1800 aaccaagagg acatttacat caccacagaa agccttacca ctgctgctgg gaggcctggg 1860 acaggagaac atgttccagg ttctgagatg cctgtcccag actatacctc cattcatata 1920 gtacagtccc cacagggcct catactcaat gcgactgcct tgcccttgcc tgacaaagag 1980 tttctctcat catgtggcta tgtgagcaca gaccaactga acaaaatcat gccttagcct 2040 ttctttggtt tcccaagagc tacgtattta atagcaaaga attgactggg gcaataacgt 2100 ttaagccaaa acaatgttta aacctttttt gggggagtga caggatgggg tatggattct 2160 aaaatgcctt ttcccaaaat gttgaaatat gatgttaaaa aaataagaag aatgcttaat 2220 cagatagata ttcctattgt gcaatgtaaa tattttaaag aattgtgtca gactgtttag 2280 tagcagtgat tgtcttaata ttgtgggtgt taatttttga tactaagcat tgaatggcta 2340 tgtttttaat gtatagtaaa tcacgctttt tgaaaaagcg aaaaaatcag gtggcttttg 2400 cggttcagga aaattgaatg caaaccatag cacaggctaa ttttttgttg tttcttaaat 2460 aagaaacttt tttatttaaa aaactaaaaa ctagaggtga gaaatttaaa ctataagcaa 2520 gaaggcaaaa atagtttgga tatgtaaaac atttattttg acataaagtt gataaagatt 2580 ttttaataat ttagacttca agcatggcta ttttatatta cactacacac tgtgtactgc 2640 agttggtatg acccctctaa ggagtgtagc aactacagtc taaagctggt ttaatgtttt 2700 ggccaatgca cctaaagaaa aacaaactcg ttttttacaa agccctttta tacctcccca 2760 gactccttca acaattctaa aatgattgta gtaatctgca ttattggaat ataattgttt 2820 tatctgaatt tttaaacaag tatttgttaa tttagaaaac tttaaagcgt ttgcacagat 2880 caacttacca ggcaccaaaa gaagtaaaag caaaaaagaa aacctttctt caccaaatct 2940 tggttgatgc caaaaaaaaa tacatgctaa gagaagtaga aatcatagct ggttcacact 3000 gaccaagata cttaagtgct gcaattgcac gcggagtgag ttttttagtg cgtgcagatg 3060 gtgagagata agatctatag cctctgcagc ggaatctgtt cacacccaac ttggttttgc 3120 tacataatta tccaggaagg gaataaggta caagaagcat tttgtaagtt gaagcaaatc 3180 gaatgaaatt aactgggtaa tgaaacaaag agttcaagaa ataagttttt gtttcacagc 3240 ctataaccag acacatactc atttttcatg ataatgaaca gaacatagac agaagaaaca 3300 aggttttcag tccccacaga taactgaaaa ttatttaaac cgctaaaaga aactttcttt 3360 ctcactaaat cttttatagg atttatttaa aatagcaaaa gaagaagttt catcattttt 3420 tacttcctct ctgagtggac tggcctcaaa gcaagcattc agaagaaaaa gaagcaacct 3480 cagtaattta gaaatcattt tgcaatccct taatatccta aacatcattc atttttgttg 3540 ttgttgttgt tgttgagaca gagtctcgct ctgtcgccag gctagagtgc ggtggcgcga 3600 tcttgactca ctgcaatctc cacctcccac aggttcaggc gattcccgtg cctcagcctc 3660 ctgagtagct gggactacag gcacgcacca ccatgccagg ctaatttttt tgtattttag 3720 cagagacggg gtttcaccat gttggccagg atggtctcga tctcctgacc tcgtgatcca 3780 cccgactcgg cctcccaaag tgctgggatt acaggtgtaa gccaccgtgc ccagccctaa 3840 acatcattct tgagagcatt gggatatctc ctgaaaaggt ttatgaaaaa gaagaatctc 3900 atctcagtga agaatacttc tcatttttta aaaaagctta aaactttgaa gttagcttta 3960 acttaaatag tatttcccat ttatcgcaga ccttttttag gaagcaagct taatggctga 4020 taattttaaa ttctctctct tgcaggaagg actatgaaaa gctagaattg agtgtttaaa 4080 gttcaacatg ttatttgtaa tagatgtttg atagattttc tgctactttg ctgctatggt 4140 tttctccaag agctacataa tttagtttca tataaagtat catcagtgta gaacctaatt 4200 caattcaaag ctgtgtgttt ggaagactat cttactattt cacaacagcc tgacaacatt 4260 tctatagcca aaaatagcta aatacctcaa tcagtctcag aatgtcattt tggtactttg 4320 gtggccacat aagccattat tcactagtat gactagttgt gtctggcagt ttatatttaa 4380 ctctctttat gtctgtggat tttttccttc aaagtttaat aaatttattt tcttggattc 4440 ctgatagtgt gcttctgtta tcaaacacca acataaaaat gatctaaacc a 4491 <210> 13 <211> 4699 <212> DNA <213> Homo sapien <400> 13 agatatgtgt gtgtgtgcat gagagagaga gattgagaat gactgatttg ggagggattt 60 tgtgaaggtt tatatatcaa agcagaaaga ccaagaattt agagattaat acatgccaag 120 tggtaaccaa gaaacttctg tgggatccca cctccaaccc ctccctctct gtcagatttt 180 aaccaaatca gtgtgatgtg atctgcttgc atatatgagt gaaagaaaaa ggaaatttaa 240 aaagttcttg atataaagcc tggaggaaac aatacgaaaa tccagcctct atttcagcaa 300 tatctgccgg actattggtc ctacaggtat ggatctctgg cagctgctgt tgaccttggc 360 actggcagga tcaagtgatg ctttttctgg aagtgaggcc acagcagcta tccttagcag 420 agcaccctgg agtctgcaaa gtgttaatcc aggcctaaag acaaattctt ctaaggagcc 480 taaattcacc aagtgccgtt cacctgagcg agagactttt tcatgccact ggacagatga 540 ggttcatcat ggtacaaaga acctaggacc catacagctg ttctatacca gaaggaacac 600 tcaagaatgg actcaagaat ggaaagaatg ccctgattat gtttctgctg gggaaaacag 660 ctgttacttt aattcatcgt ttacctccat ctggatacct tattgtatca agctaactag 720 caatggtggt acagtggatg aaaagtgttt ctctgttgat gaaatagtgc aaccagatcc 780 acccattgcc ctcaactgga ctttactgaa cgtcagttta actgggattc atgcagatat 840 ccaagtgaga tgggaagcac cacgcaatgc agatattcag aaaggatgga tggttctgga 900 gtatgaactt caatacaaag aagtaaatga aactaaatgg aaaatgatgg accctatatt 960 gacaacatca gttccagtgt actcattgaa agtggataag gaatatgaag tgcgtgtgag 1020 atccaaacaa cgaaactctg gaaattatgg cgagttcagt gaggtgctct atgtaacact 1080 tcctcagatg agccaattta catgtgaaga agatttctac tttccatggc tcttaattat 1140 tatctttgga atatttgggc taacagtgat gctatttgta ttcttatttt ctaaacagca 1200 aaggattaaa atgctgattc tgcccccagt tccagttcca aagattaaag gaatcgatcc 1260 agatctcctc aaggaaggaa aattagagga ggtgaacaca atcttagcca ttcatgatag 1320 ctataaaccc gaattccaca gtgatgactc ttgggttgaa tttattgagc tagatattga 1380 tgagccagat gaaaagactg aggaatcaga cacagacaga cttctaagca gtgaccatga 1440 gaaatcacat agtaacctag gggtgaagga tggcgactct ggacgtacca gctgttgtga 1500 acctgacatt ctggagactg atttcaatgc caatgacata catgagggta cctcagaggt 1560 tgctcagcca cagaggttaa aaggggaagc agatctctta tgccttgacc agaagaatca 1620 aaataactca ccttatcatg atgcttgccc tgctactcag cagcccagtg ttatccaagc 1680 agagaaaaac aaaccacaac cacttcctac tgaaggagct gagtcaactc accaagctgc 1740 ccatattcag ctaagcaatc caagttcact gtcaaacatc gacttttatg cccaggtgag 1800 cgacattaca ccagcaggta gtgtggtcct ttccccgggc caaaagaata aggcagggat 1860 gtcccaatgt gacatgcacc cggaaatggt ctcactctgc caagaaaact tccttatgga 1920 caatgcctac ttctgtgagg cagatgccaa aaagtgcatc cctgtggctc ctcacatcaa 1980 ggttgaatca cacatacagc caagcttaaa ccaagaggac atttacatca ccacagaaag 2040 ccttaccact gctgctggga ggcctgggac aggagaacat gttccaggtt ctgagatgcc 2100 tgtcccagac tatacctcca ttcatatagt acagtcccca cagggcctca tactcaatgc 2160 gactgccttg cccttgcctg acaaagagtt tctctcatca tgtggctatg tgagcacaga 2220 ccaactgaac aaaatcatgc cttagccttt ctttggtttc ccaagagcta cgtatttaat 2280 agcaaagaat tgactggggc aataacgttt aagccaaaac aatgtttaaa ccttttttgg 2340 gggagtgaca ggatggggta tggattctaa aatgcctttt cccaaaatgt tgaaatatga 2400 tgttaaaaaa ataagaagaa tgcttaatca gatagatatt cctattgtgc aatgtaaata 2460 ttttaaagaa ttgtgtcaga ctgtttagta gcagtgattg tcttaatatt gtgggtgtta 2520 atttttgata ctaagcattg aatggctatg tttttaatgt atagtaaatc acgctttttg 2580 aaaaagcgaa aaaatcaggt ggcttttgcg gttcaggaaa attgaatgca aaccatagca 2640 caggctaatt ttttgttgtt tcttaaataa gaaacttttt tatttaaaaa actaaaaact 2700 agaggtgaga aatttaaact ataagcaaga aggcaaaaat agtttggata tgtaaaacat 2760 ttattttgac ataaagttga taaagatttt ttaataattt agacttcaag catggctatt 2820 ttatattaca ctacacactg tgtactgcag ttggtatgac ccctctaagg agtgtagcaa 2880 ctacagtcta aagctggttt aatgttttgg ccaatgcacc taaagaaaaa caaactcgtt 2940 ttttacaaag cccttttata cctccccaga ctccttcaac aattctaaaa tgattgtagt 3000 aatctgcatt attggaatat aattgtttta tctgaatttt taaacaagta tttgttaatt 3060 tagaaaactt taaagcgttt gcacagatca acttaccagg caccaaaaga agtaaaagca 3120 aaaaagaaaa cctttcttca ccaaatcttg gttgatgcca aaaaaaaata catgctaaga 3180 gaagtagaaa tcatagctgg ttcacactga ccaagatact taagtgctgc aattgcacgc 3240 ggagtgagtt ttttagtgcg tgcagatggt gagagataag atctatagcc tctgcagcgg 3300 aatctgttca cacccaactt ggttttgcta cataattatc caggaaggga ataaggtaca 3360 agaagcattt tgtaagttga agcaaatcga atgaaattaa ctgggtaatg aaacaaagag 3420 ttcaagaaat aagtttttgt ttcacagcct ataaccagac acatactcat ttttcatgat 3480 aatgaacaga acatagacag aagaaacaag gttttcagtc cccacagata actgaaaatt 3540 atttaaaccg ctaaaagaaa ctttctttct cactaaatct tttataggat ttatttaaaa 3600 tagcaaaaga agaagtttca tcatttttta cttcctctct gagtggactg gcctcaaagc 3660 aagcattcag aagaaaaaga agcaacctca gtaatttaga aatcattttg caatccctta 3720 atatcctaaa catcattcat ttttgttgtt gttgttgttg ttgagacaga gtctcgctct 3780 gtcgccaggc tagagtgcgg tggcgcgatc ttgactcact gcaatctcca cctcccacag 3840 gttcaggcga ttcccgtgcc tcagcctcct gagtagctgg gactacaggc acgcaccacc 3900 atgccaggct aatttttttg tattttagca gagacggggt ttcaccatgt tggccaggat 3960 ggtctcgatc tcctgacctc gtgatccacc cgactcggcc tcccaaagtg ctgggattac 4020 aggtgtaagc caccgtgccc agccctaaac atcattcttg agagcattgg gatatctcct 4080 gaaaaggttt atgaaaaaga agaatctcat ctcagtgaag aatacttctc attttttaaa 4140 aaagcttaaa actttgaagt tagctttaac ttaaatagta tttcccattt atcgcagacc 4200 ttttttagga agcaagctta atggctgata attttaaatt ctctctcttg caggaaggac 4260 tatgaaaagc tagaattgag tgtttaaagt tcaacatgtt atttgtaata gatgtttgat 4320 agattttctg ctactttgct gctatggttt tctccaagag ctacataatt tagtttcata 4380 taaagtatca tcagtgtaga acctaattca attcaaagct gtgtgtttgg aagactatct 4440 tactatttca caacagcctg acaacatttc tatagccaaa aatagctaaa tacctcaatc 4500 agtctcagaa tgtcattttg gtactttggt ggccacataa gccattattc actagtatga 4560 ctagttgtgt ctggcagttt atatttaact ctctttatgt ctgtggattt tttccttcaa 4620 agtttaataa atttattttc ttggattcct gatagtgtgc ttctgttatc aaacaccaac 4680 ataaaaatga tctaaacca 4699 <210> 14 <211> 4524 <212> DNA <213> Homo sapien <400> 14 ggggaatgag tagcaaagat ggattaagtg agaagagtat aggaggcagc agggccagag 60 gtgtgaatag cccagaacct tctgagaaga ttcctttgtg gacggaagaa aggggaggtt 120 tgtggaaatg gtggaagata aggtcctaca ggtatggatc tctggcagct gctgttgacc 180 ttggcactgg caggatcaag tgatgctttt tctggaagtg aggccacagc agctatcctt 240 agcagagcac cctggagtct gcaaagtgtt aatccaggcc taaagacaaa ttcttctaag 300 gagcctaaat tcaccaagtg ccgttcacct gagcgagaga ctttttcatg ccactggaca 360 gatgaggttc atcatggtac aaagaaccta ggacccatac agctgttcta taccagaagg 420 aacactcaag aatggactca agaatggaaa gaatgccctg attatgtttc tgctggggaa 480 aacagctgtt actttaattc atcgtttacc tccatctgga taccttattg tatcaagcta 540 actagcaatg gtggtacagt ggatgaaaag tgtttctctg ttgatgaaat agtgcaacca 600 gatccaccca ttgccctcaa ctggacttta ctgaacgtca gtttaactgg gattcatgca 660 gatatccaag tgagatggga agcaccacgc aatgcagata ttcagaaagg atggatggtt 720 ctggagtatg aacttcaata caaagaagta aatgaaacta aatggaaaat gatggaccct 780 atattgacaa catcagttcc agtgtactca ttgaaagtgg ataaggaata tgaagtgcgt 840 gtgagatcca aacaacgaaa ctctggaaat tatggcgagt tcagtgaggt gctctatgta 900 acacttcctc agatgagcca atttacatgt gaagaagatt tctactttcc atggctctta 960 attattatct ttggaatatt tgggctaaca gtgatgctat ttgtattctt attttctaaa 1020 cagcaaagga ttaaaatgct gattctgccc ccagttccag ttccaaagat taaaggaatc 1080 gatccagatc tcctcaagga aggaaaatta gaggaggtga acacaatctt agccattcat 1140 gatagctata aacccgaatt ccacagtgat gactcttggg ttgaatttat tgagctagat 1200 attgatgagc cagatgaaaa gactgaggaa tcagacacag acagacttct aagcagtgac 1260 catgagaaat cacatagtaa cctaggggtg aaggatggcg actctggacg taccagctgt 1320 tgtgaacctg acattctgga gactgatttc aatgccaatg acatacatga gggtacctca 1380 gaggttgctc agccacagag gttaaaaggg gaagcagatc tcttatgcct tgaccagaag 1440 aatcaaaata actcacctta tcatgatgct tgccctgcta ctcagcagcc cagtgttatc 1500 caagcagaga aaaacaaacc acaaccactt cctactgaag gagctgagtc aactcaccaa 1560 gctgcccata ttcagctaag caatccaagt tcactgtcaa acatcgactt ttatgcccag 1620 gtgagcgaca ttacaccagc aggtagtgtg gtcctttccc cgggccaaaa gaataaggca 1680 gggatgtccc aatgtgacat gcacccggaa atggtctcac tctgccaaga aaacttcctt 1740 atggacaatg cctacttctg tgaggcagat gccaaaaagt gcatccctgt ggctcctcac 1800 atcaaggttg aatcacacat acagccaagc ttaaaccaag aggacattta catcaccaca 1860 gaaagcctta ccactgctgc tgggaggcct gggacaggag aacatgttcc aggttctgag 1920 atgcctgtcc cagactatac ctccattcat atagtacagt ccccacaggg cctcatactc 1980 aatgcgactg ccttgccctt gcctgacaaa gagtttctct catcatgtgg ctatgtgagc 2040 acagaccaac tgaacaaaat catgccttag cctttctttg gtttcccaag agctacgtat 2100 ttaatagcaa agaattgact ggggcaataa cgtttaagcc aaaacaatgt ttaaaccttt 2160 tttgggggag tgacaggatg gggtatggat tctaaaatgc cttttcccaa aatgttgaaa 2220 tatgatgtta aaaaaataag aagaatgctt aatcagatag atattcctat tgtgcaatgt 2280 aaatatttta aagaattgtg tcagactgtt tagtagcagt gattgtctta atattgtggg 2340 tgttaatttt tgatactaag cattgaatgg ctatgttttt aatgtatagt aaatcacgct 2400 ttttgaaaaa gcgaaaaaat caggtggctt ttgcggttca ggaaaattga atgcaaacca 2460 tagcacaggc taattttttg ttgtttctta aataagaaac ttttttattt aaaaaactaa 2520 aaactagagg tgagaaattt aaactataag caagaaggca aaaatagttt ggatatgtaa 2580 aacatttatt ttgacataaa gttgataaag attttttaat aatttagact tcaagcatgg 2640 ctattttata ttacactaca cactgtgtac tgcagttggt atgacccctc taaggagtgt 2700 agcaactaca gtctaaagct ggtttaatgt tttggccaat gcacctaaag aaaaacaaac 2760 tcgtttttta caaagccctt ttatacctcc ccagactcct tcaacaattc taaaatgatt 2820 gtagtaatct gcattattgg aatataattg ttttatctga atttttaaac aagtatttgt 2880 taatttagaa aactttaaag cgtttgcaca gatcaactta ccaggcacca aaagaagtaa 2940 aagcaaaaaa gaaaaccttt cttcaccaaa tcttggttga tgccaaaaaa aaatacatgc 3000 taagagaagt agaaatcata gctggttcac actgaccaag atacttaagt gctgcaattg 3060 cacgcggagt gagtttttta gtgcgtgcag atggtgagag ataagatcta tagcctctgc 3120 agcggaatct gttcacaccc aacttggttt tgctacataa ttatccagga agggaataag 3180 gtacaagaag cattttgtaa gttgaagcaa atcgaatgaa attaactggg taatgaaaca 3240 aagagttcaa gaaataagtt tttgtttcac agcctataac cagacacata ctcatttttc 3300 atgataatga acagaacata gacagaagaa acaaggtttt cagtccccac agataactga 3360 aaattattta aaccgctaaa agaaactttc tttctcacta aatcttttat aggatttatt 3420 taaaatagca aaagaagaag tttcatcatt ttttacttcc tctctgagtg gactggcctc 3480 aaagcaagca ttcagaagaa aaagaagcaa cctcagtaat ttagaaatca ttttgcaatc 3540 ccttaatatc ctaaacatca ttcatttttg ttgttgttgt tgttgttgag acagagtctc 3600 gctctgtcgc caggctagag tgcggtggcg cgatcttgac tcactgcaat ctccacctcc 3660 cacaggttca ggcgattccc gtgcctcagc ctcctgagta gctgggacta caggcacgca 3720 ccaccatgcc aggctaattt ttttgtattt tagcagagac ggggtttcac catgttggcc 3780 aggatggtct cgatctcctg acctcgtgat ccacccgact cggcctccca aagtgctggg 3840 attacaggtg taagccaccg tgcccagccc taaacatcat tcttgagagc attgggatat 3900 ctcctgaaaa ggtttatgaa aaagaagaat ctcatctcag tgaagaatac ttctcatttt 3960 ttaaaaaagc ttaaaacttt gaagttagct ttaacttaaa tagtatttcc catttatcgc 4020 agaccttttt taggaagcaa gcttaatggc tgataatttt aaattctctc tcttgcagga 4080 aggactatga aaagctagaa ttgagtgttt aaagttcaac atgttatttg taatagatgt 4140 ttgatagatt ttctgctact ttgctgctat ggttttctcc aagagctaca taatttagtt 4200 tcatataaag tatcatcagt gtagaaccta attcaattca aagctgtgtg tttggaagac 4260 tatcttacta tttcacaaca gcctgacaac atttctatag ccaaaaatag ctaaatacct 4320 caatcagtct cagaatgtca ttttggtact ttggtggcca cataagccat tattcactag 4380 tatgactagt tgtgtctggc agtttatatt taactctctt tatgtctgtg gattttttcc 4440 ttcaaagttt aataaattta ttttcttgga ttcctgatag tgtgcttctg ttatcaaaca 4500 ccaacataaa aatgatctaa acca 4524 <210> 15 <211> 4419 <212> DNA <213> Homo sapien <400> 15 caatgatatt agctatgaca gcacgtatga gcctggggtc ctacaggtat ggatctctgg 60 cagctgctgt tgaccttggc actggcagga tcaagtgatg ctttttctgg aagtgaggcc 120 acagcagcta tccttagcag agcaccctgg agtctgcaaa gtgttaatcc aggcctaaag 180 acaaattctt ctaaggagcc taaattcacc aagtgccgtt cacctgagcg agagactttt 240 tcatgccact ggacagatga ggttcatcat ggtacaaaga acctaggacc catacagctg 300 ttctatacca gaaggaacac tcaagaatgg actcaagaat ggaaagaatg ccctgattat 360 gtttctgctg gggaaaacag ctgttacttt aattcatcgt ttacctccat ctggatacct 420 tattgtatca agctaactag caatggtggt acagtggatg aaaagtgttt ctctgttgat 480 gaaatagtgc aaccagatcc acccattgcc ctcaactgga ctttactgaa cgtcagttta 540 actgggattc atgcagatat ccaagtgaga tgggaagcac cacgcaatgc agatattcag 600 aaaggatgga tggttctgga gtatgaactt caatacaaag aagtaaatga aactaaatgg 660 aaaatgatgg accctatatt gacaacatca gttccagtgt actcattgaa agtggataag 720 gaatatgaag tgcgtgtgag atccaaacaa cgaaactctg gaaattatgg cgagttcagt 780 gaggtgctct atgtaacact tcctcagatg agccaattta catgtgaaga agatttctac 840 tttccatggc tcttaattat tatctttgga atatttgggc taacagtgat gctatttgta 900 ttcttatttt ctaaacagca aaggattaaa atgctgattc tgcccccagt tccagttcca 960 aagattaaag gaatcgatcc agatctcctc aaggaaggaa aattagagga ggtgaacaca 1020 atcttagcca ttcatgatag ctataaaccc gaattccaca gtgatgactc ttgggttgaa 1080 tttattgagc tagatattga tgagccagat gaaaagactg aggaatcaga cacagacaga 1140 cttctaagca gtgaccatga gaaatcacat agtaacctag gggtgaagga tggcgactct 1200 ggacgtacca gctgttgtga acctgacatt ctggagactg atttcaatgc caatgacata 1260 catgagggta cctcagaggt tgctcagcca cagaggttaa aaggggaagc agatctctta 1320 tgccttgacc agaagaatca aaataactca ccttatcatg atgcttgccc tgctactcag 1380 cagcccagtg ttatccaagc agagaaaaac aaaccacaac cacttcctac tgaaggagct 1440 gagtcaactc accaagctgc ccatattcag ctaagcaatc caagttcact gtcaaacatc 1500 gacttttatg cccaggtgag cgacattaca ccagcaggta gtgtggtcct ttccccgggc 1560 caaaagaata aggcagggat gtcccaatgt gacatgcacc cggaaatggt ctcactctgc 1620 caagaaaact tccttatgga caatgcctac ttctgtgagg cagatgccaa aaagtgcatc 1680 cctgtggctc ctcacatcaa ggttgaatca cacatacagc caagcttaaa ccaagaggac 1740 atttacatca ccacagaaag ccttaccact gctgctggga ggcctgggac aggagaacat 1800 gttccaggtt ctgagatgcc tgtcccagac tatacctcca ttcatatagt acagtcccca 1860 cagggcctca tactcaatgc gactgccttg cccttgcctg acaaagagtt tctctcatca 1920 tgtggctatg tgagcacaga ccaactgaac aaaatcatgc cttagccttt ctttggtttc 1980 ccaagagcta cgtatttaat agcaaagaat tgactggggc aataacgttt aagccaaaac 2040 aatgtttaaa ccttttttgg gggagtgaca ggatggggta tggattctaa aatgcctttt 2100 cccaaaatgt tgaaatatga tgttaaaaaa ataagaagaa tgcttaatca gatagatatt 2160 cctattgtgc aatgtaaata ttttaaagaa ttgtgtcaga ctgtttagta gcagtgattg 2220 tcttaatatt gtgggtgtta atttttgata ctaagcattg aatggctatg tttttaatgt 2280 atagtaaatc acgctttttg aaaaagcgaa aaaatcaggt ggcttttgcg gttcaggaaa 2340 attgaatgca aaccatagca caggctaatt ttttgttgtt tcttaaataa gaaacttttt 2400 tatttaaaaa actaaaaact agaggtgaga aatttaaact ataagcaaga aggcaaaaat 2460 agtttggata tgtaaaacat ttattttgac ataaagttga taaagatttt ttaataattt 2520 agacttcaag catggctatt ttatattaca ctacacactg tgtactgcag ttggtatgac 2580 ccctctaagg agtgtagcaa ctacagtcta aagctggttt aatgttttgg ccaatgcacc 2640 taaagaaaaa caaactcgtt ttttacaaag cccttttata cctccccaga ctccttcaac 2700 aattctaaaa tgattgtagt aatctgcatt attggaatat aattgtttta tctgaatttt 2760 taaacaagta tttgttaatt tagaaaactt taaagcgttt gcacagatca acttaccagg 2820 caccaaaaga agtaaaagca aaaaagaaaa cctttcttca ccaaatcttg gttgatgcca 2880 aaaaaaaata catgctaaga gaagtagaaa tcatagctgg ttcacactga ccaagatact 2940 taagtgctgc aattgcacgc ggagtgagtt ttttagtgcg tgcagatggt gagagataag 3000 atctatagcc tctgcagcgg aatctgttca cacccaactt ggttttgcta cataattatc 3060 caggaaggga ataaggtaca agaagcattt tgtaagttga agcaaatcga atgaaattaa 3120 ctgggtaatg aaacaaagag ttcaagaaat aagtttttgt ttcacagcct ataaccagac 3180 acatactcat ttttcatgat aatgaacaga acatagacag aagaaacaag gttttcagtc 3240 cccacagata actgaaaatt atttaaaccg ctaaaagaaa ctttctttct cactaaatct 3300 tttataggat ttatttaaaa tagcaaaaga agaagtttca tcatttttta cttcctctct 3360 gagtggactg gcctcaaagc aagcattcag aagaaaaaga agcaacctca gtaatttaga 3420 aatcattttg caatccctta atatcctaaa catcattcat ttttgttgtt gttgttgttg 3480 ttgagacaga gtctcgctct gtcgccaggc tagagtgcgg tggcgcgatc ttgactcact 3540 gcaatctcca cctcccacag gttcaggcga ttcccgtgcc tcagcctcct gagtagctgg 3600 gactacaggc acgcaccacc atgccaggct aatttttttg tattttagca gagacggggt 3660 ttcaccatgt tggccaggat ggtctcgatc tcctgacctc gtgatccacc cgactcggcc 3720 tcccaaagtg ctgggattac aggtgtaagc caccgtgccc agccctaaac atcattcttg 3780 agagcattgg gatatctcct gaaaaggttt atgaaaaaga agaatctcat ctcagtgaag 3840 aatacttctc attttttaaa aaagcttaaa actttgaagt tagctttaac ttaaatagta 3900 tttcccattt atcgcagacc ttttttagga agcaagctta atggctgata attttaaatt 3960 ctctctcttg caggaaggac tatgaaaagc tagaattgag tgtttaaagt tcaacatgtt 4020 atttgtaata gatgtttgat agattttctg ctactttgct gctatggttt tctccaagag 4080 ctacataatt tagtttcata taaagtatca tcagtgtaga acctaattca attcaaagct 4140 gtgtgtttgg aagactatct tactatttca caacagcctg acaacatttc tatagccaaa 4200 aatagctaaa tacctcaatc agtctcagaa tgtcattttg gtactttggt ggccacataa 4260 gccattattc actagtatga ctagttgtgt ctggcagttt atatttaact ctctttatgt 4320 ctgtggattt tttccttcaa agtttaataa atttattttc ttggattcct gatagtgtgc 4380 ttctgttatc aaacaccaac ataaaaatga tctaaacca 4419 <210> 16 <211> 4785 <212> DNA <213> Homo sapien <400> 16 cctgtccagc tcaaggcccc atgctttctg atactgctga taaggttttc tatttccaga 60 tcaaattaaa gcaaacctta ctggccctgt tactgaagct gtgcatgggg gtcgtttgct 120 gtgaggtgtt tctatggctt tgagccaggg tatgaacatc tctagtgttc atgttatttc 180 ctgagactag cactcacggg aagtagaatt tattacaacc tgctgtttga gttcatgaaa 240 agtaggacaa tatgagactc tggggcagtg aaagacttac caggattcct tctggaactg 300 actcgtcagc tcattcatgt cttacccagt ctttaaacag tatttcatga taatggtctg 360 cttttaattg ctgggcttta ccttaccctt tttgtgattg caggtcctac aggtatggat 420 ctctggcagc tgctgttgac cttggcactg gcaggatcaa gtgatgcttt ttctggaagt 480 gaggccacag cagctatcct tagcagagca ccctggagtc tgcaaagtgt taatccaggc 540 ctaaagacaa attcttctaa ggagcctaaa ttcaccaagt gccgttcacc tgagcgagag 600 actttttcat gccactggac agatgaggtt catcatggta caaagaacct aggacccata 660 cagctgttct ataccagaag gaacactcaa gaatggactc aagaatggaa agaatgccct 720 gattatgttt ctgctgggga aaacagctgt tactttaatt catcgtttac ctccatctgg 780 ataccttatt gtatcaagct aactagcaat ggtggtacag tggatgaaaa gtgtttctct 840 gttgatgaaa tagtgcaacc agatccaccc attgccctca actggacttt actgaacgtc 900 agtttaactg ggattcatgc agatatccaa gtgagatggg aagcaccacg caatgcagat 960 attcagaaag gatggatggt tctggagtat gaacttcaat acaaagaagt aaatgaaact 1020 aaatggaaaa tgatggaccc tatattgaca acatcagttc cagtgtactc attgaaagtg 1080 gataaggaat atgaagtgcg tgtgagatcc aaacaacgaa actctggaaa ttatggcgag 1140 ttcagtgagg tgctctatgt aacacttcct cagatgagcc aatttacatg tgaagaagat 1200 ttctactttc catggctctt aattattatc tttggaatat ttgggctaac agtgatgcta 1260 tttgtattct tattttctaa acagcaaagg attaaaatgc tgattctgcc cccagttcca 1320 gttccaaaga ttaaaggaat cgatccagat ctcctcaagg aaggaaaatt agaggaggtg 1380 aacacaatct tagccattca tgatagctat aaacccgaat tccacagtga tgactcttgg 1440 gttgaattta ttgagctaga tattgatgag ccagatgaaa agactgagga atcagacaca 1500 gacagacttc taagcagtga ccatgagaaa tcacatagta acctaggggt gaaggatggc 1560 gactctggac gtaccagctg ttgtgaacct gacattctgg agactgattt caatgccaat 1620 gacatacatg agggtacctc agaggttgct cagccacaga ggttaaaagg ggaagcagat 1680 ctcttatgcc ttgaccagaa gaatcaaaat aactcacctt atcatgatgc ttgccctgct 1740 actcagcagc ccagtgttat ccaagcagag aaaaacaaac cacaaccact tcctactgaa 1800 ggagctgagt caactcacca agctgcccat attcagctaa gcaatccaag ttcactgtca 1860 aacatcgact tttatgccca ggtgagcgac attacaccag caggtagtgt ggtcctttcc 1920 ccgggccaaa agaataaggc agggatgtcc caatgtgaca tgcacccgga aatggtctca 1980 ctctgccaag aaaacttcct tatggacaat gcctacttct gtgaggcaga tgccaaaaag 2040 tgcatccctg tggctcctca catcaaggtt gaatcacaca tacagccaag cttaaaccaa 2100 gaggacattt acatcaccac agaaagcctt accactgctg ctgggaggcc tgggacagga 2160 gaacatgttc caggttctga gatgcctgtc ccagactata cctccattca tatagtacag 2220 tccccacagg gcctcatact caatgcgact gccttgccct tgcctgacaa agagtttctc 2280 tcatcatgtg gctatgtgag cacagaccaa ctgaacaaaa tcatgcctta gcctttcttt 2340 ggtttcccaa gagctacgta tttaatagca aagaattgac tggggcaata acgtttaagc 2400 caaaacaatg tttaaacctt ttttggggga gtgacaggat ggggtatgga ttctaaaatg 2460 ccttttccca aaatgttgaa atatgatgtt aaaaaaataa gaagaatgct taatcagata 2520 gatattccta ttgtgcaatg taaatatttt aaagaattgt gtcagactgt ttagtagcag 2580 tgattgtctt aatattgtgg gtgttaattt ttgatactaa gcattgaatg gctatgtttt 2640 taatgtatag taaatcacgc tttttgaaaa agcgaaaaaa tcaggtggct tttgcggttc 2700 aggaaaattg aatgcaaacc atagcacagg ctaatttttt gttgtttctt aaataagaaa 2760 cttttttatt taaaaaacta aaaactagag gtgagaaatt taaactataa gcaagaaggc 2820 aaaaatagtt tggatatgta aaacatttat tttgacataa agttgataaa gattttttaa 2880 taatttagac ttcaagcatg gctattttat attacactac acactgtgta ctgcagttgg 2940 tatgacccct ctaaggagtg tagcaactac agtctaaagc tggtttaatg ttttggccaa 3000 tgcacctaaa gaaaaacaaa ctcgtttttt acaaagccct tttatacctc cccagactcc 3060 ttcaacaatt ctaaaatgat tgtagtaatc tgcattattg gaatataatt gttttatctg 3120 aatttttaaa caagtatttg ttaatttaga aaactttaaa gcgtttgcac agatcaactt 3180 accaggcacc aaaagaagta aaagcaaaaa agaaaacctt tcttcaccaa atcttggttg 3240 atgccaaaaa aaaatacatg ctaagagaag tagaaatcat agctggttca cactgaccaa 3300 gatacttaag tgctgcaatt gcacgcggag tgagtttttt agtgcgtgca gatggtgaga 3360 gataagatct atagcctctg cagcggaatc tgttcacacc caacttggtt ttgctacata 3420 attatccagg aagggaataa ggtacaagaa gcattttgta agttgaagca aatcgaatga 3480 aattaactgg gtaatgaaac aaagagttca agaaataagt ttttgtttca cagcctataa 3540 ccagacacat actcattttt catgataatg aacagaacat agacagaaga aacaaggttt 3600 tcagtcccca cagataactg aaaattattt aaaccgctaa aagaaacttt ctttctcact 3660 aaatctttta taggatttat ttaaaatagc aaaagaagaa gtttcatcat tttttacttc 3720 ctctctgagt ggactggcct caaagcaagc attcagaaga aaaagaagca acctcagtaa 3780 tttagaaatc attttgcaat cccttaatat cctaaacatc attcattttt gttgttgttg 3840 ttgttgttga gacagagtct cgctctgtcg ccaggctaga gtgcggtggc gcgatcttga 3900 ctcactgcaa tctccacctc ccacaggttc aggcgattcc cgtgcctcag cctcctgagt 3960 agctgggact acaggcacgc accaccatgc caggctaatt tttttgtatt ttagcagaga 4020 cggggtttca ccatgttggc caggatggtc tcgatctcct gacctcgtga tccacccgac 4080 tcggcctccc aaagtgctgg gattacaggt gtaagccacc gtgcccagcc ctaaacatca 4140 ttcttgagag cattgggata tctcctgaaa aggtttatga aaaagaagaa tctcatctca 4200 gtgaagaata cttctcattt tttaaaaaag cttaaaactt tgaagttagc tttaacttaa 4260 atagtatttc ccatttatcg cagacctttt ttaggaagca agcttaatgg ctgataattt 4320 taaattctct ctcttgcagg aaggactatg aaaagctaga attgagtgtt taaagttcaa 4380 catgttattt gtaatagatg tttgatagat tttctgctac tttgctgcta tggttttctc 4440 caagagctac ataatttagt ttcatataaa gtatcatcag tgtagaacct aattcaattc 4500 aaagctgtgt gtttggaaga ctatcttact atttcacaac agcctgacaa catttctata 4560 gccaaaaata gctaaatacc tcaatcagtc tcagaatgtc attttggtac tttggtggcc 4620 acataagcca ttattcacta gtatgactag ttgtgtctgg cagtttatat ttaactctct 4680 ttatgtctgt ggattttttc cttcaaagtt taataaattt attttcttgg attcctgata 4740 gtgtgcttct gttatcaaac accaacataa aaatgatcta aacca 4785 <210> 17 <211> 4316 <212> DNA <213> Homo sapien <400> 17 gtcctacagg tatggatctc tggcagctgc tgttgacctt ggcactggca ggatcaagtg 60 atgctttttc tggaagtgag gattcttcta aggagcctaa attcaccaag tgccgttcac 120 ctgagcgaga gactttttca tgccactgga cagatgaggt tcatcatggt acaaagaacc 180 taggacccat acagctgttc tataccagaa ggaacactca agaatggact caagaatgga 240 aagaatgccc tgattatgtt tctgctgggg aaaacagctg ttactttaat tcatcgttta 300 cctccatctg gataccttat tgtatcaagc taactagcaa tggtggtaca gtggatgaaa 360 agtgtttctc tgttgatgaa atagtgcaac cagatccacc cattgccctc aactggactt 420 tactgaacgt cagtttaact gggattcatg cagatatcca agtgagatgg gaagcaccac 480 gcaatgcaga tattcagaaa ggatggatgg ttctggagta tgaacttcaa tacaaagaag 540 taaatgaaac taaatggaaa atgatggacc ctatattgac aacatcagtt ccagtgtact 600 cattgaaagt ggataaggaa tatgaagtgc gtgtgagatc caaacaacga aactctggaa 660 attatggcga gttcagtgag gtgctctatg taacacttcc tcagatgagc caatttacat 720 gtgaagaaga tttctacttt ccatggctct taattattat ctttggaata tttgggctaa 780 cagtgatgct atttgtattc ttattttcta aacagcaaag gattaaaatg ctgattctgc 840 ccccagttcc agttccaaag attaaaggaa tcgatccaga tctcctcaag gaaggaaaat 900 tagaggaggt gaacacaatc ttagccattc atgatagcta taaacccgaa ttccacagtg 960 atgactcttg ggttgaattt attgagctag atattgatga gccagatgaa aagactgagg 1020 aatcagacac agacagactt ctaagcagtg accatgagaa atcacatagt aacctagggg 1080 tgaaggatgg cgactctgga cgtaccagct gttgtgaacc tgacattctg gagactgatt 1140 tcaatgccaa tgacatacat gagggtacct cagaggttgc tcagccacag aggttaaaag 1200 gggaagcaga tctcttatgc cttgaccaga agaatcaaaa taactcacct tatcatgatg 1260 cttgccctgc tactcagcag cccagtgtta tccaagcaga gaaaaacaaa ccacaaccac 1320 ttcctactga aggagctgag tcaactcacc aagctgccca tattcagcta agcaatccaa 1380 gttcactgtc aaacatcgac ttttatgccc aggtgagcga cattacacca gcaggtagtg 1440 tggtcctttc cccgggccaa aagaataagg cagggatgtc ccaatgtgac atgcacccgg 1500 aaatggtctc actctgccaa gaaaacttcc ttatggacaa tgcctacttc tgtgaggcag 1560 atgccaaaaa gtgcatccct gtggctcctc acatcaaggt tgaatcacac atacagccaa 1620 gcttaaacca agaggacatt tacatcacca cagaaagcct taccactgct gctgggaggc 1680 ctgggacagg agaacatgtt ccaggttctg agatgcctgt cccagactat acctccattc 1740 atatagtaca gtccccacag ggcctcatac tcaatgcgac tgccttgccc ttgcctgaca 1800 aagagtttct ctcatcatgt ggctatgtga gcacagacca actgaacaaa atcatgcctt 1860 agcctttctt tggtttccca agagctacgt atttaatagc aaagaattga ctggggcaat 1920 aacgtttaag ccaaaacaat gtttaaacct tttttggggg agtgacagga tggggtatgg 1980 attctaaaat gccttttccc aaaatgttga aatatgatgt taaaaaaata agaagaatgc 2040 ttaatcagat agatattcct attgtgcaat gtaaatattt taaagaattg tgtcagactg 2100 tttagtagca gtgattgtct taatattgtg ggtgttaatt tttgatacta agcattgaat 2160 ggctatgttt ttaatgtata gtaaatcacg ctttttgaaa aagcgaaaaa atcaggtggc 2220 ttttgcggtt caggaaaatt gaatgcaaac catagcacag gctaattttt tgttgtttct 2280 taaataagaa acttttttat ttaaaaaact aaaaactaga ggtgagaaat ttaaactata 2340 agcaagaagg caaaaatagt ttggatatgt aaaacattta ttttgacata aagttgataa 2400 agatttttta ataatttaga cttcaagcat ggctatttta tattacacta cacactgtgt 2460 actgcagttg gtatgacccc tctaaggagt gtagcaacta cagtctaaag ctggtttaat 2520 gttttggcca atgcacctaa agaaaaacaa actcgttttt tacaaagccc ttttatacct 2580 ccccagactc cttcaacaat tctaaaatga ttgtagtaat ctgcattatt ggaatataat 2640 tgttttatct gaatttttaa acaagtattt gttaatttag aaaactttaa agcgtttgca 2700 cagatcaact taccaggcac caaaagaagt aaaagcaaaa aagaaaacct ttcttcacca 2760 aatcttggtt gatgccaaaa aaaaatacat gctaagagaa gtagaaatca tagctggttc 2820 acactgacca agatacttaa gtgctgcaat tgcacgcgga gtgagttttt tagtgcgtgc 2880 agatggtgag agataagatc tatagcctct gcagcggaat ctgttcacac ccaacttggt 2940 tttgctacat aattatccag gaagggaata aggtacaaga agcattttgt aagttgaagc 3000 aaatcgaatg aaattaactg ggtaatgaaa caaagagttc aagaaataag tttttgtttc 3060 acagcctata accagacaca tactcatttt tcatgataat gaacagaaca tagacagaag 3120 aaacaaggtt ttcagtcccc acagataact gaaaattatt taaaccgcta aaagaaactt 3180 tctttctcac taaatctttt ataggattta tttaaaatag caaaagaaga agtttcatca 3240 ttttttactt cctctctgag tggactggcc tcaaagcaag cattcagaag aaaaagaagc 3300 aacctcagta atttagaaat cattttgcaa tcccttaata tcctaaacat cattcatttt 3360 tgttgttgtt gttgttgttg agacagagtc tcgctctgtc gccaggctag agtgcggtgg 3420 cgcgatcttg actcactgca atctccacct cccacaggtt caggcgattc ccgtgcctca 3480 gcctcctgag tagctgggac tacaggcacg caccaccatg ccaggctaat ttttttgtat 3540 tttagcagag acggggtttc accatgttgg ccaggatggt ctcgatctcc tgacctcgtg 3600 atccacccga ctcggcctcc caaagtgctg ggattacagg tgtaagccac cgtgcccagc 3660 cctaaacatc attcttgaga gcattgggat atctcctgaa aaggtttatg aaaaagaaga 3720 atctcatctc agtgaagaat acttctcatt ttttaaaaaa gcttaaaact ttgaagttag 3780 ctttaactta aatagtattt cccatttatc gcagaccttt tttaggaagc aagcttaatg 3840 gctgataatt ttaaattctc tctcttgcag gaaggactat gaaaagctag aattgagtgt 3900 ttaaagttca acatgttatt tgtaatagat gtttgataga ttttctgcta ctttgctgct 3960 atggttttct ccaagagcta cataatttag tttcatataa agtatcatca gtgtagaacc 4020 taattcaatt caaagctgtg tgtttggaag actatcttac tatttcacaa cagcctgaca 4080 acatttctat agccaaaaat agctaaatac ctcaatcagt ctcagaatgt cattttggta 4140 ctttggtggc cacataagcc attattcact agtatgacta gttgtgtctg gcagtttata 4200 tttaactctc tttatgtctg tggatttttt ccttcaaagt ttaataaatt tattttcttg 4260 gattcctgat agtgtgcttc tgttatcaaa caccaacata aaaatgatct aaacca 4316 <210> 18 <211> 4356 <212> DNA <213> Homo sapien <400> 18 gtcctacagg tatggatctc tggcagctgc tgttgacctt ggcactggca ggatcaagtg 60 atgctttttc tggaagtgag gccacagcag ctatccttag cagagcaccc tggagtctgc 120 aaagtgttaa tccaggccta aagacaaatt cttctaagga gcctaaattc accaagtgcc 180 gttcacctga gcgagagact ttttcatgcc actggacaga tgaggttcat catggtacaa 240 agaacctagg acccatacag ctgttctata ccagaaggaa cactcaagaa tggactcaag 300 aatggaaaga atgccctgat tatgtttctg ctggggaaaa cagctgttac tttaattcat 360 cgtttacctc catctggata ccttattgta tcaagctaac tagcaatggt ggtacagtgg 420 atgaaaagtg tttctctgtt gatgaaatag tgcaaccaga tccacccatt gccctcaact 480 ggactttact gaacgtcagt ttaactggga ttcatgcaga tatccaagtg agatgggaag 540 caccacgcaa tgcagatatt cagaaaggat ggatggttct ggagtatgaa cttcaataca 600 aagaagtaaa tgaaactaaa tggaaaatga tggaccctat attgacaaca tcagttccag 660 tgtactcatt gaaagtggat aaggaatatg aagtgcgtgt gagatccaaa caacgaaact 720 ctggaaatta tggcgagttc agtgaggtgc tctatgtaac acttcctcag atgagccaat 780 ttacatgtga agaagatttc tactttccat ggctcttaat tattatcttt ggaatatttg 840 ggctaacagt gatgctattt gtattcttat tttctaaaca gcaaagttcc agttccaaag 900 attaaaggaa tcgatccaga tctcctcaag gaaggaaaat tagaggaggt gaacacaatc 960 ttagccattc atgatagcta taaacccgaa ttccacagtg atgactcttg ggttgaattt 1020 attgagctag atattgatga gccagatgaa aagactgagg aatcagacac agacagactt 1080 ctaagcagtg accatgagaa atcacatagt aacctagggg tgaaggatgg cgactctgga 1140 cgtaccagct gttgtgaacc tgacattctg gagactgatt tcaatgccaa tgacatacat 1200 gagggtacct cagaggttgc tcagccacag aggttaaaag gggaagcaga tctcttatgc 1260 cttgaccaga agaatcaaaa taactcacct tatcatgatg cttgccctgc tactcagcag 1320 cccagtgtta tccaagcaga gaaaaacaaa ccacaaccac ttcctactga aggagctgag 1380 tcaactcacc aagctgccca tattcagcta agcaatccaa gttcactgtc aaacatcgac 1440 ttttatgccc aggtgagcga cattacacca gcaggtagtg tggtcctttc cccgggccaa 1500 aagaataagg cagggatgtc ccaatgtgac atgcacccgg aaatggtctc actctgccaa 1560 gaaaacttcc ttatggacaa tgcctacttc tgtgaggcag atgccaaaaa gtgcatccct 1620 gtggctcctc acatcaaggt tgaatcacac atacagccaa gcttaaacca agaggacatt 1680 tacatcacca cagaaagcct taccactgct gctgggaggc ctgggacagg agaacatgtt 1740 ccaggttctg agatgcctgt cccagactat acctccattc atatagtaca gtccccacag 1800 ggcctcatac tcaatgcgac tgccttgccc ttgcctgaca aagagtttct ctcatcatgt 1860 ggctatgtga gcacagacca actgaacaaa atcatgcctt agcctttctt tggtttccca 1920 agagctacgt atttaatagc aaagaattga ctggggcaat aacgtttaag ccaaaacaat 1980 gtttaaacct tttttggggg agtgacagga tggggtatgg attctaaaat gccttttccc 2040 aaaatgttga aatatgatgt taaaaaaata agaagaatgc ttaatcagat agatattcct 2100 attgtgcaat gtaaatattt taaagaattg tgtcagactg tttagtagca gtgattgtct 2160 taatattgtg ggtgttaatt tttgatacta agcattgaat ggctatgttt ttaatgtata 2220 gtaaatcacg ctttttgaaa aagcgaaaaa atcaggtggc ttttgcggtt caggaaaatt 2280 gaatgcaaac catagcacag gctaattttt tgttgtttct taaataagaa acttttttat 2340 ttaaaaaact aaaaactaga ggtgagaaat ttaaactata agcaagaagg caaaaatagt 2400 ttggatatgt aaaacattta ttttgacata aagttgataa agatttttta ataatttaga 2460 cttcaagcat ggctatttta tattacacta cacactgtgt actgcagttg gtatgacccc 2520 tctaaggagt gtagcaacta cagtctaaag ctggtttaat gttttggcca atgcacctaa 2580 agaaaaacaa actcgttttt tacaaagccc ttttatacct ccccagactc cttcaacaat 2640 tctaaaatga ttgtagtaat ctgcattatt ggaatataat tgttttatct gaatttttaa 2700 acaagtattt gttaatttag aaaactttaa agcgtttgca cagatcaact taccaggcac 2760 caaaagaagt aaaagcaaaa aagaaaacct ttcttcacca aatcttggtt gatgccaaaa 2820 aaaaatacat gctaagagaa gtagaaatca tagctggttc acactgacca agatacttaa 2880 gtgctgcaat tgcacgcgga gtgagttttt tagtgcgtgc agatggtgag agataagatc 2940 tatagcctct gcagcggaat ctgttcacac ccaacttggt tttgctacat aattatccag 3000 gaagggaata aggtacaaga agcattttgt aagttgaagc aaatcgaatg aaattaactg 3060 ggtaatgaaa caaagagttc aagaaataag tttttgtttc acagcctata accagacaca 3120 tactcatttt tcatgataat gaacagaaca tagacagaag aaacaaggtt ttcagtcccc 3180 acagataact gaaaattatt taaaccgcta aaagaaactt tctttctcac taaatctttt 3240 ataggattta tttaaaatag caaaagaaga agtttcatca ttttttactt cctctctgag 3300 tggactggcc tcaaagcaag cattcagaag aaaaagaagc aacctcagta atttagaaat 3360 cattttgcaa tcccttaata tcctaaacat cattcatttt tgttgttgtt gttgttgttg 3420 agacagagtc tcgctctgtc gccaggctag agtgcggtgg cgcgatcttg actcactgca 3480 atctccacct cccacaggtt caggcgattc ccgtgcctca gcctcctgag tagctgggac 3540 tacaggcacg caccaccatg ccaggctaat ttttttgtat tttagcagag acggggtttc 3600 accatgttgg ccaggatggt ctcgatctcc tgacctcgtg atccacccga ctcggcctcc 3660 caaagtgctg ggattacagg tgtaagccac cgtgcccagc cctaaacatc attcttgaga 3720 gcattgggat atctcctgaa aaggtttatg aaaaagaaga atctcatctc agtgaagaat 3780 acttctcatt ttttaaaaaa gcttaaaact ttgaagttag ctttaactta aatagtattt 3840 cccatttatc gcagaccttt tttaggaagc aagcttaatg gctgataatt ttaaattctc 3900 tctcttgcag gaaggactat gaaaagctag aattgagtgt ttaaagttca acatgttatt 3960 tgtaatagat gtttgataga ttttctgcta ctttgctgct atggttttct ccaagagcta 4020 cataatttag tttcatataa agtatcatca gtgtagaacc taattcaatt caaagctgtg 4080 tgtttggaag actatcttac tatttcacaa cagcctgaca acatttctat agccaaaaat 4140 agctaaatac ctcaatcagt ctcagaatgt cattttggta ctttggtggc cacataagcc 4200 attattcact agtatgacta gttgtgtctg gcagtttata tttaactctc tttatgtctg 4260 tggatttttt ccttcaaagt ttaataaatt tattttcttg gattcctgat agtgtgcttc 4320 tgttatcaaa caccaacata aaaatgatct aaacca 4356 <210> 19 <211> 4312 <212> DNA <213> Homo sapien <400> 19 gtcctacagg tatggatctc tggcagctgc tgttgacctt ggcactggca ggatcaagtg 60 atgctttttc tggaagtgag gccacagcag ctatccttag cagagcaccc tggagtctgc 120 aaagtgttaa tccaggccta aagacaaatt cttctaagga gcctaaattc accaagtgcc 180 gttcacctga gcgagagact ttttcatgcc actggacaga tgaggttcat catggtacaa 240 agaacctagg acccatacag ctgttctata ccagaaggaa cactcaagaa tggactcaag 300 aatggaaaga atgccctgat tatgtttctg ctggggaaaa cagctgttac tttaattcat 360 cgtttacctc catctggata ccttattgta tcaagctaac tagcaatggt ggtacagtgg 420 atgaaaagtg tttctctgtt gatgaaatag tgcaaccaga tccacccatt gccctcaact 480 ggactttact gaacgtcagt ttaactggga ttcatgcaga tatccaagtg agatgggaag 540 caccacgcaa tgcagatatt cagaaaggat ggatggttct ggagtatgaa cttcaataca 600 aagaagtaaa tgaaactaaa tggaaaatga tggaccctat attgacaaca tcagttccag 660 tgtactcatt gaaagtggat aaggaatatg aagtgcgtgt gagatccaaa caacgaaact 720 ctggaaatta tggcgagttc agtgaggtgc tctatgtaac acttcctcag atgagccaat 780 ttacatgtga agaagatttc tactttccat ggctcttaat tattatcttt ggaatatttg 840 ggctaacagt gatgctattt gtattcttat tttctaaaca gcaaaggaag gaaaattaga 900 ggaggtgaac acaatcttag ccattcatga tagctataaa cccgaattcc acagtgatga 960 ctcttgggtt gaatttattg agctagatat tgatgagcca gatgaaaaga ctgaggaatc 1020 agacacagac agacttctaa gcagtgacca tgagaaatca catagtaacc taggggtgaa 1080 ggatggcgac tctggacgta ccagctgttg tgaacctgac attctggaga ctgatttcaa 1140 tgccaatgac atacatgagg gtacctcaga ggttgctcag ccacagaggt taaaagggga 1200 agcagatctc ttatgccttg accagaagaa tcaaaataac tcaccttatc atgatgcttg 1260 ccctgctact cagcagccca gtgttatcca agcagagaaa aacaaaccac aaccacttcc 1320 tactgaagga gctgagtcaa ctcaccaagc tgcccatatt cagctaagca atccaagttc 1380 actgtcaaac atcgactttt atgcccaggt gagcgacatt acaccagcag gtagtgtggt 1440 cctttccccg ggccaaaaga ataaggcagg gatgtcccaa tgtgacatgc acccggaaat 1500 ggtctcactc tgccaagaaa acttccttat ggacaatgcc tacttctgtg aggcagatgc 1560 caaaaagtgc atccctgtgg ctcctcacat caaggttgaa tcacacatac agccaagctt 1620 aaaccaagag gacatttaca tcaccacaga aagccttacc actgctgctg ggaggcctgg 1680 gacaggagaa catgttccag gttctgagat gcctgtccca gactatacct ccattcatat 1740 agtacagtcc ccacagggcc tcatactcaa tgcgactgcc ttgcccttgc ctgacaaaga 1800 gtttctctca tcatgtggct atgtgagcac agaccaactg aacaaaatca tgccttagcc 1860 tttctttggt ttcccaagag ctacgtattt aatagcaaag aattgactgg ggcaataacg 1920 tttaagccaa aacaatgttt aaaccttttt tgggggagtg acaggatggg gtatggattc 1980 taaaatgcct tttcccaaaa tgttgaaata tgatgttaaa aaaataagaa gaatgcttaa 2040 tcagatagat attcctattg tgcaatgtaa atattttaaa gaattgtgtc agactgttta 2100 gtagcagtga ttgtcttaat attgtgggtg ttaatttttg atactaagca ttgaatggct 2160 atgtttttaa tgtatagtaa atcacgcttt ttgaaaaagc gaaaaaatca ggtggctttt 2220 gcggttcagg aaaattgaat gcaaaccata gcacaggcta attttttgtt gtttcttaaa 2280 taagaaactt ttttatttaa aaaactaaaa actagaggtg agaaatttaa actataagca 2340 agaaggcaaa aatagtttgg atatgtaaaa catttatttt gacataaagt tgataaagat 2400 tttttaataa tttagacttc aagcatggct attttatatt acactacaca ctgtgtactg 2460 cagttggtat gacccctcta aggagtgtag caactacagt ctaaagctgg tttaatgttt 2520 tggccaatgc acctaaagaa aaacaaactc gttttttaca aagccctttt atacctcccc 2580 agactccttc aacaattcta aaatgattgt agtaatctgc attattggaa tataattgtt 2640 ttatctgaat ttttaaacaa gtatttgtta atttagaaaa ctttaaagcg tttgcacaga 2700 tcaacttacc aggcaccaaa agaagtaaaa gcaaaaaaga aaacctttct tcaccaaatc 2760 ttggttgatg ccaaaaaaaa atacatgcta agagaagtag aaatcatagc tggttcacac 2820 tgaccaagat acttaagtgc tgcaattgca cgcggagtga gttttttagt gcgtgcagat 2880 ggtgagagat aagatctata gcctctgcag cggaatctgt tcacacccaa cttggttttg 2940 ctacataatt atccaggaag ggaataaggt acaagaagca ttttgtaagt tgaagcaaat 3000 cgaatgaaat taactgggta atgaaacaaa gagttcaaga aataagtttt tgtttcacag 3060 cctataacca gacacatact catttttcat gataatgaac agaacataga cagaagaaac 3120 aaggttttca gtccccacag ataactgaaa attatttaaa ccgctaaaag aaactttctt 3180 tctcactaaa tcttttatag gatttattta aaatagcaaa agaagaagtt tcatcatttt 3240 ttacttcctc tctgagtgga ctggcctcaa agcaagcatt cagaagaaaa agaagcaacc 3300 tcagtaattt agaaatcatt ttgcaatccc ttaatatcct aaacatcatt catttttgtt 3360 gttgttgttg ttgttgagac agagtctcgc tctgtcgcca ggctagagtg cggtggcgcg 3420 atcttgactc actgcaatct ccacctccca caggttcagg cgattcccgt gcctcagcct 3480 cctgagtagc tgggactaca ggcacgcacc accatgccag gctaattttt ttgtatttta 3540 gcagagacgg ggtttcacca tgttggccag gatggtctcg atctcctgac ctcgtgatcc 3600 acccgactcg gcctcccaaa gtgctgggat tacaggtgta agccaccgtg cccagcccta 3660 aacatcattc ttgagagcat tgggatatct cctgaaaagg tttatgaaaa agaagaatct 3720 catctcagtg aagaatactt ctcatttttt aaaaaagctt aaaactttga agttagcttt 3780 aacttaaata gtatttccca tttatcgcag acctttttta ggaagcaagc ttaatggctg 3840 ataattttaa attctctctc ttgcaggaag gactatgaaa agctagaatt gagtgtttaa 3900 agttcaacat gttatttgta atagatgttt gatagatttt ctgctacttt gctgctatgg 3960 ttttctccaa gagctacata atttagtttc atataaagta tcatcagtgt agaacctaat 4020 tcaattcaaa gctgtgtgtt tggaagacta tcttactatt tcacaacagc ctgacaacat 4080 ttctatagcc aaaaatagct aaatacctca atcagtctca gaatgtcatt ttggtacttt 4140 ggtggccaca taagccatta ttcactagta tgactagttg tgtctggcag tttatattta 4200 actctcttta tgtctgtgga ttttttcctt caaagtttaa taaatttatt ttcttggatt 4260 cctgatagtg tgcttctgtt atcaaacacc aacataaaaa tgatctaaac ca 4312 <210> 20 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 20 acctccgagc ttcgcctctg 20 <210> 21 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 21 ctgtaggacc tccgagcttc 20 <210> 22 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 22 tccatacctg taggacctcc 20 <210> 23 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 23 tgccaaggtc aacagcagct 20 <210> 24 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 24 ctgccagtgc caaggtcaac 20 <210> 25 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 25 cttgatcctg ccagtgccaa 20 <210> 26 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 26 agcatcactt gatcctgcca 20 <210> 27 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 27 cagaaaaagc atcacttgat 20 <210> 28 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 28 tcacttccag aaaaagcatc 20 <210> 29 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 29 gtctctcgct caggtgaacg 20 <210> 30 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 30 tgaaaaagtc tctcgctcag 20 <210> 31 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 31 agtggcatga aaaagtctct 20 <210> 32 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 32 tctgtccagt ggcatgaaaa 20 <210> 33 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 33 ggatctggtt gcactatttc 20 <210> 34 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 34 aatgggtgga tctggttgca 20 <210> 35 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 35 agtccagttg agggcaatgg 20 <210> 36 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 36 tcagtaaagt ccagttgagg 20 <210> 37 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 37 gaatcccagt taaactgacg 20 <210> 38 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 38 tctgcatgaa tcccagttaa 20 <210> 39 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 39 atccatcctt tctgaatatc 20 <210> 40 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 40 cagaaccatc catcctttct 20 <210> 41 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 41 catactccag aaccatccat 20 <210> 42 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 42 tgaagttcat actccagaac 20 <210> 43 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 43 tttgtattga agttcatact 20 <210> 44 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 44 ttacttcttt gtattgaagt 20 <210> 45 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 45 gtttcattta cttctttgta 20 <210> 46 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 46 ccatttagtt tcatttactt 20 <210> 47 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 47 tcattttcca tttagtttca 20 <210> 48 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 48 acacgcactt catattcctt 20 <210> 49 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 49 ggatctcaca cgcacttcat 20 <210> 50 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 50 aagtgttaca tagagcacct 20 <210> 51 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 51 tctgaggaag tgttacatag 20 <210> 52 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 52 cttcttcaca tgtaaattgg 20 <210> 53 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 53 tagaaatctt cttcacatgt 20 <210> 54 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 54 tggaaagtag aaatcttctt 20 <210> 55 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 55 agagccatgg aaagtagaaa 20 <210> 56 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 56 ataattaaga gccatggaaa 20 <210> 57 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 57 cagttggtct gtgctcacat 20 <210> 58 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 58 gtgccaaggt caacagcagc 20 <210> 59 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 59 agtgccaagg tcaacagcag 20 <210> 60 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 60 catcacttga tcctgccagt 20 <210> 61 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 61 gcatcacttg atcctgccag 20 <210> 62 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 62 aagcatcact tgatcctgcc 20 <210> 63 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 63 aaagcatcac ttgatcctgc 20 <210> 64 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 64 atctcacacg cacttcatat 20 <210> 65 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 65 gatctcacac gcacttcata 20 <210> 66 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 66 tggatctcac acgcacttca 20 <210> 67 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 67 ttggatctca cacgcacttc 20 <210> 68 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 68 tccagaatgt caggttcaca 20 <210> 69 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 69 ctccagaatg tcaggttcac 20 <210> 70 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 70 gtctccagaa tgtcaggttc 20 <210> 71 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 71 agtctccaga atgtcaggtt 20 <210> 72 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 72 gcttggataa cactgggctg 20 <210> 73 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 73 tgcttggata acactgggct 20 <210> 74 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 74 tctgcttgga taacactggg 20 <210> 75 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 75 ctctgcttgg ataacactgg 20 <210> 76 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 76 tctctgcttg gataacactg 20 <210> 77 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 77 cagagtgaga ccatttccgg 20 <210> 78 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 78 gcagagtgag accatttccg 20 <210> 79 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 79 tggcagagtg agaccatttc 20 <210> 80 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 80 ttggcagagt gagaccattt 20 <210> 81 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 81 cttggcagag tgagaccatt 20 <210> 82 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 82 cagtgtgtag tgtaatataa 20 <210> 83 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 83 acagtgtgta gtgtaatata 20 <210> 84 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 84 acacagtgtg tagtgtaata 20 <210> 85 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 85 tacacagtgt gtagtgtaat 20 <210> 86 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 86 gtacacagtg tgtagtgtaa 20 <210> 87 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 87 tgtaccttat tcccttcctg 20 <210> 88 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 88 ttgtacctta ttcccttcct 20 <210> 89 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 89 tcttgtacct tattcccttc 20 <210> 90 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 90 ttcttgtacc ttattccctt 20 <210> 91 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 91 acatgtaccc aaaccaacac 20 <210> 92 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 92 cttcttgtac cttattccct 20 <210> 93 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 93 tgcttcttgt accttattcc 20 <210> 94 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 94 atgcttcttg taccttattc 20 <210> 95 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 95 aaatgcttct tgtaccttat 20 <210> 96 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 96 aaaatgcttc ttgtacctta 20 <210> 97 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 97 caaaatgctt cttgtacctt 20 <210> 98 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 98 cttctgaatg cttgctttga 20 <210> 99 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 99 tcttctgaat gcttgctttg 20 <210> 100 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 100 tttcttctga atgcttgctt 20 <210> 101 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 101 ttttcttctg aatgcttgct 20 <210> 102 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 102 tttttcttct gaatgcttgc 20 <210> 103 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 103 tgcgataaat gggaaatact 20 <210> 104 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 104 ctgcgataaa tgggaaatac 20 <210> 105 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 105 tctgcgataa atgggaaata 20 <210> 106 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 106 ggtctgcgat aaatgggaaa 20 <210> 107 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 107 aggtctgcga taaatgggaa 20 <210> 108 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 108 aaaggtctgc gataaatggg 20 <210> 109 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 109 aaaaggtctg cgataaatgg 20 <210> 110 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 110 aaaaaggtct gcgataaatg 20 <210> 111 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 111 catgaaggcc actcttccaa 20 <210> 112 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 112 ccatgaaggc cactcttcca 20 <210> 113 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 113 cccatgaagg ccactcttcc 20 <210> 114 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 114 tgcccatgaa ggccactctt 20 <210> 115 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 115 ttgcccatga aggccactct 20 <210> 116 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 116 gttgcccatg aaggccactc 20 <210> 117 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 117 ggtctttcat gaatcaagct 20 <210> 118 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 118 tggtctttca tgaatcaagc 20 <210> 119 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 119 atggtctttc atgaatcaag 20 <210> 120 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 120 tgatggtctt tcatgaatca 20 <210> 121 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 121 ctgatggtct ttcatgaatc 20 <210> 122 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 122 gctgatggtc tttcatgaat 20 <210> 123 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 123 gtacccaaac caacactaat 20 <210> 124 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 124 tgtacccaaa ccaacactaa 20 <210> 125 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 125 atgtacccaa accaacacta 20 <210> 126 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 126 gacatgtacc caaaccaaca 20 <210> 127 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 127 agacatgtac ccaaaccaac 20 <210> 128 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 128 aggaatggaa aaccaaatat 20 <210> 129 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 129 caggaatgga aaaccaaata 20 <210> 130 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 130 tcaggaatgg aaaaccaaat 20 <210> 131 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 131 actcaggaat ggaaaaccaa 20 <210> 132 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 132 aactcaggaa tggaaaacca 20 <210> 133 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 133 taactcagga atggaaaacc 20 <210> 134 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 134 caaaattact gcagtcacag 20 <210> 135 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 135 acaaaattac tgcagtcaca 20 <210> 136 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 136 tacaaaatta ctgcagtcac 20 <210> 137 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 137 catacaaaat tactgcagtc 20 <210> 138 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 138 acatacaaaa ttactgcagt 20 <210> 139 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 139 aacatacaaa attactgcag 20 <210> 140 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 140 ttttagtatg aaccttaaaa 20 <210> 141 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 141 cttttagtat gaaccttaaa 20 <210> 142 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 142 tcttttagta tgaaccttaa 20 <210> 143 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 143 aatcttttag tatgaacctt 20 <210> 144 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 144 caatctttta gtatgaacct 20 <210> 145 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 145 acaatctttt agtatgaacc 20 <210> 146 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 146 aagttatgtg actctgagca 20 <210> 147 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 147 caagttatgt gactctgagc 20 <210> 148 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 148 tcaagttatg tgactctgag 20 <210> 149 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 149 agttctccat tagggttctg 20 <210> 150 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 150 tagttctcca ttagggttct 20 <210> 151 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 151 atagttctcc attagggttc 20 <210> 152 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 152 aagcaggttg gcagacagac 20 <210> 153 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 153 gaagcaggtt ggcagacaga 20 <210> 154 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 154 ggaagcaggt tggcagacag 20 <210> 155 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 155 tcttcttgtg agctggcttc 20 <210> 156 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 156 gtcttcttgt gagctggctt 20 <210> 157 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 157 agtcttcttg tgagctggct 20 <210> 158 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 158 taagtcttct tgtgagctgg 20 <210> 159 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 159 ttaagtcttc ttgtgagctg 20 <210> 160 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 160 attaagtctt cttgtgagct 20 <210> 161 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 161 tctcttccac tcacatccat 20 <210> 162 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 162 gtctcttcca ctcacatcca 20 <210> 163 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 163 agtctcttcc actcacatcc 20 <210> 164 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 164 taagtatttg tagcagttgc 20 <210> 165 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 165 ctaagtattt gtagcagttg 20 <210> 166 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 166 gctaagtatt tgtagcagtt 20 <210> 167 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 167 tggctaagta tttgtagcag 20 <210> 168 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 168 ttggctaagt atttgtagca 20 <210> 169 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 169 tttggctaag tatttgtagc 20 <210> 170 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 170 aaaatgtcaa cagtgcatag 20 <210> 171 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 171 caaaatgtca acagtgcata 20 <210> 172 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 172 ccaaaatgtc aacagtgcat 20 <210> 173 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 173 gcccaaaatg tcaacagtgc 20 <210> 174 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 174 ggcccaaaat gtcaacagtg 20 <210> 175 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 175 tggcccaaaa tgtcaacagt 20 <210> 176 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 176 cagaatcttc tctttggcca 20 <210> 177 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 177 gcagaatctt ctctttggcc 20 <210> 178 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 178 tgcagaatct tctctttggc 20 <210> 179 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 179 tttgcagaat cttctctttg 20 <210> 180 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 180 atttgcagaa tcttctcttt 20 <210> 181 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 181 aatttgcaga atcttctctt 20 <210> 182 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 182 ataaagctat gccataaagc 20 <210> 183 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 183 cataaagcta tgccataaag 20 <210> 184 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 184 ccataaagct atgccataaa 20 <210> 185 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 185 gaccataaag ctatgccata 20 <210> 186 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 186 tgaccataaa gctatgccat 20 <210> 187 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 187 ctgaccataa agctatgcca 20 <210> 188 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 188 caaaaagttg agctgagaaa 20 <210> 189 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 189 ccaaaaagtt gagctgagaa 20 <210> 190 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 190 cccaaaaagt tgagctgaga 20 <210> 191 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 191 cacccaaaaa gttgagctga 20 <210> 192 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 192 acacccaaaa agttgagctg 20 <210> 193 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 193 tacacccaaa aagttgagct 20 <210> 194 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 194 cttttaatgg cacccaagca 20 <210> 195 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 195 gcttttaatg gcacccaagc 20 <210> 196 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 196 tgcttttaat ggcacccaag 20 <210> 197 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 197 aatgctttta atggcaccca 20 <210> 198 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 198 aaatgctttt aatggcaccc 20 <210> 199 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 199 gaaatgcttt taatggcacc 20 <210> 200 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 200 taattcttaa gggccctctg 20 <210> 201 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 201 ataattctta agggccctct 20 <210> 202 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 202 cataattctt aagggccctc 20 <210> 203 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 203 agcataattc ttaagggccc 20 <210> 204 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 204 tagcataatt cttaagggcc 20 <210> 205 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 205 ttagcataat tcttaagggc 20 <210> 206 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 206 aggaatggaa aaccaaacat 20 <210> 207 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 207 caggaatgga aaaccaaaca 20 <210> 208 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 208 tcaggaatgg aaaaccaaac 20 <210> 209 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 209 aggaatggaa aaccaaatac 20 <210> 210 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 210 catgactatg ttctggcaag 20 <210> 211 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 211 acatgactat gttctggcaa 20 <210> 212 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 212 cacatgacta tgttctggca 20 <210> 213 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 213 gtcacatgac tatgttctgg 20 <210> 214 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 214 ggtcacatga ctatgttctg 20 <210> 215 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 215 tggtcacatg actatgttct 20 <210> 216 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 216 ctgaattctg agctctggaa 20 <210> 217 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 217 cctgaattct gagctctgga 20 <210> 218 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 218 gcctgaattc tgagctctgg 20 <210> 219 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 219 aagcctgaat tctgagctct 20 <210> 220 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 220 caagcctgaa ttctgagctc 20 <210> 221 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 221 acaagcctga attctgagct 20 <210> 222 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 222 ggatctcagc tgcaattctt 20 <210> 223 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 223 aggatctcag ctgcaattct 20 <210> 224 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 224 gaggatctca gctgcaattc 20 <210> 225 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 225 cagaggatct cagctgcaat 20 <210> 226 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 226 gcagaggatc tcagctgcaa 20 <210> 227 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 227 aaaagcatca cttgatcctg 20 <210> 228 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 228 caaggtcaac agcagct 17 <210> 229 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 229 ccaaggtcaa cagcagc 17 <210> 230 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 230 gccaaggtca acagcag 17 <210> 231 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 231 tctcacacgc acttcat 17 <210> 232 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 232 atctcacacg cacttca 17 <210> 233 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 233 gatctcacac gcacttc 17 <210> 234 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 234 ctttcatgaa tcaagct 17 <210> 235 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 235 tctttcatga atcaagc 17 <210> 236 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 236 gtctttcatg aatcaag 17 <210> 237 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 237 ggtctttcat gaatcaa 17 <210> 238 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 238 atggtctttc atgaatc 17 <210> 239 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 239 gatggtcttt catgaat 17 <210> 240 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 240 tatatcaata ttctccc 17 <210> 241 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 241 ttatatcaat attctcc 17 <210> 242 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 242 gttatatcaa tattctc 17 <210> 243 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 243 tttctttagc aatagtt 17 <210> 244 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 244 ctttctttag caatagt 17 <210> 245 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 245 gctttcttta gcaatag 17 <210> 246 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 246 aggaatggaa aaccaaa 17 <210> 247 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 247 caggaatgga aaaccaa 17 <210> 248 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 248 tcaggaatgg aaaacca 17 <210> 249 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 249 tctccattag ggttctg 17 <210> 250 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 250 ttctccatta gggttct 17 <210> 251 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 251 gttctccatt agggttc 17 <210> 252 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 252 aggttggcag acagaca 17 <210> 253 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 253 caggttggca gacagac 17 <210> 254 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 254 gcaggttggc agacaga 17 <210> 255 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 255 cttcttgtga gctggct 17 <210> 256 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 256 tcttcttgtg agctggc 17 <210> 257 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 257 gtcttcttgt gagctgg 17 <210> 258 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 258 agtcttcttg tgagctg 17 <210> 259 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 259 tcttccactc acatcca 17 <210> 260 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 260 ctcttccact cacatcc 17 <210> 261 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 261 tctcttccac tcacatc 17 <210> 262 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 262 gtctcttcca ctcacat 17 <210> 263 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 263 atagattttg acttccc 17 <210> 264 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 264 catagatttt gacttcc 17 <210> 265 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 265 gcatagattt tgacttc 17 <210> 266 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 266 aaaatgtcaa cagtgca 17 <210> 267 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 267 caaaatgtca acagtgc 17 <210> 268 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 268 ccaaaatgtc aacagtg 17 <210> 269 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 269 cccaaaatgt caacagt 17 <210> 270 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 270 catgactatg ttctggc 17 <210> 271 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 271 acatgactat gttctgg 17 <210> 272 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 272 cacatgacta tgttctg 17 <210> 273 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 273 gaattctgag ctctgga 17 <210> 274 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 274 tgaattctga gctctgg 17 <210> 275 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 275 ctgaattctg agctctg 17 <210> 276 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 276 cctgaattct gagctct 17 <210> 277 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 277 gcctgaattc tgagctc 17 <210> 278 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 278 agcctgaatt ctgagct 17 <210> 279 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 279 atattgtaat tcttggt 17 <210> 280 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 280 gatattgtaa ttcttgg 17 <210> 281 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 281 tgatattgta attcttg 17 <210> 282 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 282 ctgatattgt aattctt 17 <210> 283 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 283 cctgatattg taattct 17 <210> 284 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 284 gcctgatatt gtaattc 17 <210> 285 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 285 tgcctgatat tgtaatt 17 <210> 286 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 286 aattatgtgc tttgcct 17 <210> 287 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 287 caattatgtg ctttgcc 17 <210> 288 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 288 tcaattatgt gctttgc 17 <210> 289 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 289 gtcaattatg tgctttg 17 <210> 290 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 290 gccatcacca aacacca 17 <210> 291 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 291 tgccatcacc aaacacc 17 <210> 292 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 292 ttgccatcac caaacac 17 <210> 293 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 293 tggtgactct gcctgat 17 <210> 294 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 294 ctggtgactc tgcctga 17 <210> 295 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 295 tatttcagaa agactttctg 20 <210> 296 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 296 aggaaaaaat caaggagtta 20 <210> 297 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 297 tatttactga acacctattc 20 <210> 298 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 298 gcccatgaag gccactcttc 20 <210> 299 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 299 acctataaat aaagtgagga 20 <210> 300 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 300 gtttcataac ctgctaataa 20 <210> 301 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 301 atgtgcctta cagttatcag 20 <210> 302 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 302 ttctgaattt agaattatag 20 <210> 303 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 303 gtttataatc tagcagttac 20 <210> 304 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 304 gatggtcttt catgaatcaa 20 <210> 305 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 305 catgtaccca aaccaacact 20 <210> 306 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 306 taaaatacag cctacatcat 20 <210> 307 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 307 ccatcactac aacaaactca 20 <210> 308 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 308 atctgaaatg atcccctttc 20 <210> 309 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 309 tgttgcccct ccaaaaagac 20 <210> 310 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 310 attaaaattt taaatgatgt 20 <210> 311 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 311 ctcaggaatg gaaaaccaaa 20 <210> 312 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 312 aaaattctag aagataacat 20 <210> 313 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 313 ctagaagtcc tagccagagt 20 <210> 314 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 314 aaccgatatc acagaaatac 20 <210> 315 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 315 aagatagaca gtaacataat 20 <210> 316 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 316 gcactacaag aactgcttaa 20 <210> 317 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 317 tttccagaca aagaattcag 20 <210> 318 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 318 gtagacagcc tttctggaac 20 <210> 319 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 319 catcctacat agtggctgtg 20 <210> 320 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 320 cagaacagtg tgtggagact 20 <210> 321 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 321 agctttaaaa atacctctgc 20 <210> 322 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 322 cccaggtact tgctctcaga 20 <210> 323 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 323 ttacacctga ttctagaaat 20 <210> 324 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 324 cttttctcta caacctcaca 20 <210> 325 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 325 tagtagtttg aatttcaaag 20 <210> 326 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 326 atacaaaatt actgcagtca 20 <210> 327 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 327 gccactgcca aaaaggagga 20 <210> 328 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 328 tgacagaaac agagctatga 20 <210> 329 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 329 atcttttagt atgaacctta 20 <210> 330 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 330 agttatgtga ctctgagcac 20 <210> 331 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 331 actatgccct agttacttct 20 <210> 332 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 332 tatagtggaa gtgatagatc 20 <210> 333 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 333 tgttttctga aatggaatgt 20 <210> 334 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 334 gctgtaaatg taatgagtgt 20 <210> 335 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 335 gagagaagcc atggccctag 20 <210> 336 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 336 ctctctttcc cagaacaaga 20 <210> 337 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 337 tccaaaatgt ccagtataat 20 <210> 338 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 338 gttctccatt agggttctgg 20 <210> 339 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 339 ttagtcaccc atccaccact 20 <210> 340 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 340 catgaattca ccgagttagg 20 <210> 341 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 341 agcaggttgg cagacagaca 20 <210> 342 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 342 gaaagactta aattttcaca 20 <210> 343 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 343 tagtagagga aaaggagaat 20 <210> 344 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 344 aaacagggtc tggagtggac 20 <210> 345 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 345 caagctgata attaaaaaga 20 <210> 346 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 346 ataaagatac attttctggg 20 <210> 347 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 347 caggattctt cctgcctggc 20 <210> 348 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 348 aagtcttctt gtgagctggc 20 <210> 349 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 349 ctcttccact cacatccatt 20 <210> 350 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 350 cctatatcag aagacaaatg 20 <210> 351 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 351 tcaaaaccct gccaaggtac 20 <210> 352 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 352 tcatattcta cttctgttta 20 <210> 353 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 353 cattccagtg tttcagtaag 20 <210> 354 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 354 ggcctggaat taatcctcag 20 <210> 355 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 355 aatgccctct ccctgtgcct 20 <210> 356 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 356 tttataatca acctttgcta 20 <210> 357 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 357 atataactac ttaaaataat 20 <210> 358 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 358 ttagccagga tatggttgcc 20 <210> 359 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 359 ctacctccat caaagaaaat 20 <210> 360 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 360 gcatgcatag ataagtttga 20 <210> 361 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 361 atgagagtaa atggattttc 20 <210> 362 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 362 ttggcaatcc ttgcttaaaa 20 <210> 363 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 363 gaattaagcc agacttattt 20 <210> 364 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 364 ggctaagtat ttgtagcagt 20 <210> 365 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 365 ttgcctgtgt gcaactggcg 20 <210> 366 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 366 gtggccttag taggccagct 20 <210> 367 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 367 cccaaaatgt caacagtgca 20 <210> 368 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 368 ttaagccttc aatttgaaaa 20 <210> 369 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 369 tgctcagaag gttgagcata 20 <210> 370 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 370 ttaatgcttt cccaaagctc 20 <210> 371 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 371 aaaagacttc atacctttac 20 <210> 372 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 372 ggccccctgg cacaacagga 20 <210> 373 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 373 tctagggtga ttcaggtgga 20 <210> 374 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 374 cttagattaa tgcaaaacaa 20 <210> 375 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 375 aggcagagga gggtggaacc 20 <210> 376 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 376 agtctaatga gatctgatgg 20 <210> 377 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 377 gctgaaatga gttaagactt 20 <210> 378 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 378 actttggact gtggattttt 20 <210> 379 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 379 gcatatttac acaatgcctg 20 <210> 380 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 380 ggaaatgcct ggatgtccag 20 <210> 381 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 381 ctgctgattt tggaatggag 20 <210> 382 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 382 actgaacacc tattctatgg 20 <210> 383 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 383 tttactgaac acctattcta 20 <210> 384 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 384 ccctcaaatt atccacaaac 20 <210> 385 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 385 cttctaaatg tttccaaggc 20 <210> 386 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 386 ttacatcctg taggctaatt 20 <210> 387 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 387 ccactagcct ggccagactt 20 <210> 388 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 388 ctggtagatg atctcaagtt 20 <210> 389 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 389 aaagaattga gttataaatc 20 <210> 390 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 390 aactcatctc tggccagcag 20 <210> 391 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 391 caacatcatt gtattttctg 20 <210> 392 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 392 tcttagctta ccaatgagga 20 <210> 393 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 393 ttcccagagc caaagctcaa 20 <210> 394 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 394 tttggccaat cccagcttat 20 <210> 395 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 395 gtttgcaaat cttcattcac 20 <210> 396 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 396 caatagtccc tgaggcttgg 20 <210> 397 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 397 tttccccaga ttaaatgccc 20 <210> 398 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 398 ttcaataatg cagttattat 20 <210> 399 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 399 aaattcttgg gcttaagcac 20 <210> 400 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 400 tgatccaaat tcagtaccta 20 <210> 401 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 401 gatgatccaa attcagtacc 20 <210> 402 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 402 caatattcat ctttatattc 20 <210> 403 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 403 attgctctta agataagtaa 20 <210> 404 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 404 cagctccctg aatatctctt 20 <210> 405 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 405 acttcacaaa tatattataa 20 <210> 406 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 406 gtacagtcaa ctttacttca 20 <210> 407 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 407 caattcccac tcttgtcaac 20 <210> 408 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 408 tcaactgctt tctggagcag 20 <210> 409 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 409 actgctgagc acctccaaaa 20 <210> 410 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 410 cttagattcc tggtttatca 20 <210> 411 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 411 agttatatca atattctccc 20 <210> 412 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 412 tataccatct tccccataaa 20 <210> 413 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 413 ggctttcttt agcaatagtt 20 <210> 414 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 414 taccagggat gtaggtttac 20 <210> 415 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 415 tcacagctga attctatctg 20 <210> 416 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 416 ggagatggac aaattcctgc 20 <210> 417 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 417 ctagacatgt catcaagaca 20 <210> 418 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 418 caaattaata aaacaattac 20 <210> 419 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 419 tattcttata tcagacaaaa 20 <210> 420 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 420 tcaagggatc cctgccattc 20 <210> 421 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 421 cgtcaaggga tccctgccat 20 <210> 422 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 422 ggcactccca gtctccagct 20 <210> 423 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 423 tttctccagc agaagtgtca 20 <210> 424 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 424 aagtcctctt ccgcctccct 20 <210> 425 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 425 ggaatttacc aaaaacagtt 20 <210> 426 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 426 agttaggtat tgtccatttt 20 <210> 427 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 427 acatgggtat cttctaggaa 20 <210> 428 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 428 tcagtttcag agagacaaaa 20 <210> 429 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 429 tttgccaggt cctatgtcga 20 <210> 430 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 430 attccctttt ctctacaacc 20 <210> 431 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 431 atgataagag ccaagatttg 20 <210> 432 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 432 gaaaaaaggt ccactgtggt 20 <210> 433 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 433 cctgtcctgg aatagtttca 20 <210> 434 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 434 tagaaaagta aataaggaat 20 <210> 435 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 435 ttataaaact atgcaatagg 20 <210> 436 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 436 ttatttcata tttccagaaa 20 <210> 437 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 437 catgaattac agctaaagat 20 <210> 438 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 438 ttgcatgtat gtgtttctga 20 <210> 439 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 439 tcaatctctt tataccctta 20 <210> 440 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 440 tcttcaatct ctttataccc 20 <210> 441 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 441 ctatgcccta gttacttcta 20 <210> 442 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 442 aaagagaatc tcttcctttt 20 <210> 443 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 443 tcattaaaga ttattataac 20 <210> 444 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 444 tttggatgag tggaaggcta 20 <210> 445 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 445 ggaaatggcc tttttcctta 20 <210> 446 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 446 ggagaagccc tctgcctgta 20 <210> 447 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 447 aaaccatatt gtccaccaga 20 <210> 448 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 448 ctcaaaccat attgtccacc 20 <210> 449 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 449 gtgtaaatag tgacttgtac 20 <210> 450 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 450 tgaggcacag gaaagttaac 20 <210> 451 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 451 agctatagtt ctccattagg 20 <210> 452 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 452 ttacttgctg actaagccat 20 <210> 453 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 453 gtttgtcaac tcaacatcaa 20 <210> 454 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 454 gactatttgt atatatatac 20 <210> 455 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 455 atgactattt gtatatatat 20 <210> 456 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 456 actcttcctt atatttgctc 20 <210> 457 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 457 atacactgac ttttaacatt 20 <210> 458 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 458 cttagaaaca gtagtttcat 20 <210> 459 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 459 ctgagctttg ccttaagaat 20 <210> 460 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 460 caccagacag caggtagagc 20 <210> 461 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 461 gagatggagt agaaggcaaa 20 <210> 462 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 462 taggaaagga agaatacact 20 <210> 463 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 463 tagaccagga agggtgagag 20 <210> 464 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 464 aagttggatc tggcatgcat 20 <210> 465 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 465 aaagttggat ctggcatgca 20 <210> 466 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 466 ccataactct tctaactggg 20 <210> 467 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 467 atattaaagt ttgagaacta 20 <210> 468 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 468 cttaactaca aaatgctgga 20 <210> 469 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 469 tgagcagctg tcctcagttc 20 <210> 470 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 470 gagttcataa aagttttact 20 <210> 471 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 471 ctatccacac cattccataa 20 <210> 472 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 472 aacatctaag taatgcaaac 20 <210> 473 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 473 tttgcattca aagccctggg 20 <210> 474 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 474 tccatattat aggctatgat 20 <210> 475 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 475 attttatgat aatgtaaaac 20 <210> 476 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 476 gagatcacat tttctgagta 20 <210> 477 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 477 acctccctag gattacctca 20 <210> 478 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 478 aaaatctgat ttataatcaa 20 <210> 479 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 479 agcatagatt ttgacttccc 20 <210> 480 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 480 aaagtcatat acacaggtct 20 <210> 481 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 481 ctcatagcaa attcccagaa 20 <210> 482 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 482 caacatggag gctagcatgt 20 <210> 483 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 483 agactaagtg gcctgaatgt 20 <210> 484 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 484 acctaccatg tcactctcaa 20 <210> 485 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 485 aactttcttg tgttttatca 20 <210> 486 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 486 tttgcaagac aaagaaatga 20 <210> 487 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 487 catgcaaagt gttcctcttc 20 <210> 488 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 488 agtgctttgc tttctcttat 20 <210> 489 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 489 gaacaagaaa cacttggtaa 20 <210> 490 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 490 agtgttccaa ttaaatggca 20 <210> 491 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 491 aaacaatgcc cttgtagtga 20 <210> 492 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 492 tattctaggt tttgaggtga 20 <210> 493 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 493 atattctagg ttttgaggtg 20 <210> 494 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 494 gttttccatt ctttaagaaa 20 <210> 495 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 495 agcaatccat tgattgtatg 20 <210> 496 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 496 aattatggca aaatggaaaa 20 <210> 497 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 497 acatttgctt atgagactat 20 <210> 498 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 498 gcagagataa tcctatgatg 20 <210> 499 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 499 tccatctgtt acctctctgt 20 <210> 500 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 500 tttgcctgaa gggcagaacc 20 <210> 501 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 501 gaaaaaatca gattttcaca 20 <210> 502 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 502 aacttaattt aatcatttct 20 <210> 503 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 503 tttggttgtc atgagttgag 20 <210> 504 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 504 ttccatctct agggcacttt 20 <210> 505 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 505 agagcttatt ttcaaaattc 20 <210> 506 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 506 ataaagagca aacaaacata 20 <210> 507 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 507 tataaattcc ttggtctgat 20 <210> 508 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 508 aaaatataaa ttccttggtc 20 <210> 509 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 509 ttttataaca gcctctgaca 20 <210> 510 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 510 aaaagaccat gttgcttatt 20 <210> 511 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 511 atagtcagtc agaatgtggt 20 <210> 512 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 512 tgccttagct tggaaaagac 20 <210> 513 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 513 agggctagct gatgcctctc 20 <210> 514 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 514 ttggactggg ctcaaacaga 20 <210> 515 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 515 aaagtcaggc tagagggact 20 <210> 516 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 516 tccttgtttt cttgtaatga 20 <210> 517 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 517 acaccagagg aaggaaatca 20 <210> 518 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 518 gatgtacacc attttgaatt 20 <210> 519 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 519 tgctctggcc tagcctatgt 20 <210> 520 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 520 cagaggtgtc tcccaagaaa 20 <210> 521 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 521 aaagagaatg gatcaaagct 20 <210> 522 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 522 gatttgcaga acaaatcttg 20 <210> 523 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 523 tggttatgaa ggttggacca 20 <210> 524 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 524 tggctaatta atgggcaatt 20 <210> 525 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 525 ctgtgccata ttgcctctaa 20 <210> 526 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 526 gatttcaacc agctcacctg 20 <210> 527 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 527 gcaaaaggga accctgaagc 20 <210> 528 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 528 ctaagtgtta taacaaacac 20 <210> 529 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 529 gtccattggt ataaaactca 20 <210> 530 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 530 tttcaataca ataagattta 20 <210> 531 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 531 gtccttagac ccctcaatgg 20 <210> 532 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 532 gaggatttat tcatctaggc 20 <210> 533 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 533 cagtgggagg atcagatatc 20 <210> 534 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 534 atcccatcca gcagctggac 20 <210> 535 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 535 aacttgggat gagttactga 20 <210> 536 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 536 gaaggctacc taaaagaaat 20 <210> 537 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 537 aaagaaatat tcacaacatt 20 <210> 538 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 538 atgcttatac tgctgctgta 20 <210> 539 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 539 tcctcacttc aatcaccttt 20 <210> 540 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 540 ctctttcttc ataaataagt 20 <210> 541 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 541 tggtaatctg tgtcccttta 20 <210> 542 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 542 taataaaaaa gtttgaaaca 20 <210> 543 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 543 ggtggtggca agagaaaaat 20 <210> 544 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 544 caaaaggccc tttttacatg 20 <210> 545 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 545 actctactgg taccaattta 20 <210> 546 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 546 tctgaacttt tatgctctgt 20 <210> 547 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 547 aacttttgcc tgggcatcca 20 <210> 548 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 548 tgactccatg tctcacatcc 20 <210> 549 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 549 ttacttccta gatacaacag 20 <210> 550 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 550 ctggccccca tgattcaatt 20 <210> 551 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 551 aagactggcc cccatgattc 20 <210> 552 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 552 tgtcactggt ctgtgtattt 20 <210> 553 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 553 acagagtaga tttagcataa 20 <210> 554 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 554 taaacaggtg tactattaca 20 <210> 555 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 555 gctttatcaa ctaagtttat 20 <210> 556 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 556 cagaacttct tttaaaattg 20 <210> 557 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 557 gaatacagac ataccttgaa 20 <210> 558 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 558 ccatgacaac aatttcagag 20 <210> 559 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 559 acaaatagca atgaatgggt 20 <210> 560 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 560 caacaaatag caatgaatgg 20 <210> 561 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 561 gtacacaaat cagtagctct 20 <210> 562 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 562 ctatgtcaaa aagactgaaa 20 <210> 563 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 563 atatacagaa catttcatcc 20 <210> 564 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 564 agaatagata agaactcacc 20 <210> 565 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 565 aggaaagata cagtcatttt 20 <210> 566 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 566 gcacaaagaa cacctgggaa 20 <210> 567 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 567 caagaagtct gggattatgt 20 <210> 568 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 568 gttagttatt aagctaatca 20 <210> 569 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 569 aaccattatt tataggctaa 20 <210> 570 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 570 ccagaatgcg atcacttctt 20 <210> 571 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 571 ccagaaatta tcctcctctc 20 <210> 572 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 572 agggaaatgc aaattaaaac 20 <210> 573 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 573 gcatcaagat acagaaaaat 20 <210> 574 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 574 gaatgtttat gagatttttc 20 <210> 575 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 575 gccaattata ttgccacatt 20 <210> 576 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 576 atacttgctt atgtagaaat 20 <210> 577 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 577 taatacttgc ttatgtagaa 20 <210> 578 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 578 gaacacatgg cattctgata 20 <210> 579 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 579 cagaatttgc agtataaatc 20 <210> 580 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 580 tatgttttga aatcttattt 20 <210> 581 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 581 actcactgct acctcattaa 20 <210> 582 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 582 aagcagtgat agggtatctg 20 <210> 583 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 583 atgaggccta ttacaatgga 20 <210> 584 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 584 ctggagtctc atgaggccta 20 <210> 585 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 585 tgactatcag ccttttaatc 20 <210> 586 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 586 ttcagagaac aacctttgaa 20 <210> 587 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 587 agccatgtgt gatctgatgt 20 <210> 588 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 588 gaaatttact ccaaactagc 20 <210> 589 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 589 aacatccaga ccaccatcta 20 <210> 590 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 590 gtaccaaacc attcatgctc 20 <210> 591 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 591 agtaccaaac cattcatgct 20 <210> 592 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 592 ttatagagct tgagattgac 20 <210> 593 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 593 agtccattat agagcttgag 20 <210> 594 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 594 aaccatgaga tgcaatgcag 20 <210> 595 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 595 aggattgaga atcgctgatt 20 <210> 596 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 596 tctaaagcat ggccaggatt 20 <210> 597 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 597 gggactgagt attgatactt 20 <210> 598 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 598 agaagtaggg tgttccagat 20 <210> 599 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 599 agaaatagtc ttcctactaa 20 <210> 600 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 600 gcctccttta agcttctatg 20 <210> 601 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 601 ggcctgcctt tactttccca 20 <210> 602 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 602 acctcagtgg actctttcca 20 <210> 603 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 603 caaacctaag ttcaagtcct 20 <210> 604 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 604 agtttcactt cttgaatcaa 20 <210> 605 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 605 aagatcaaat gaggtcaagg 20 <210> 606 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 606 tagatacaaa tttcatcaca 20 <210> 607 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 607 attcctaaaa taggagcagg 20 <210> 608 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 608 tttttatgtt gtataagata 20 <210> 609 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 609 gttcagccaa tacatgagta 20 <210> 610 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 610 ccagagggag ttcattacca 20 <210> 611 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 611 tctctctaat tcaaccttat 20 <210> 612 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 612 ataatcctca gacctcttta 20 <210> 613 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 613 cactgtggca gaattccaag 20 <210> 614 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 614 acaccttggt gcctagaagc 20 <210> 615 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 615 gtagcaatga cacctaagaa 20 <210> 616 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 616 tttaaaataa taaatgctta 20 <210> 617 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 617 tcatttggtc cttagacccc 20 <210> 618 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 618 ttattcatct aggccgagtg 20 <210> 619 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 619 ttgcagaatc ttctctttgg 20 <210> 620 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 620 accataaagc tatgccataa 20 <210> 621 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 621 ggcaaggagc acaataggac 20 <210> 622 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 622 acccaaaaag ttgagctgag 20 <210> 623 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 623 tagattttca gactctttct 20 <210> 624 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 624 aatttcaata ttgttgtgtt 20 <210> 625 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 625 atgcttttaa tggcacccaa 20 <210> 626 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 626 catgtctcac atccaggtca 20 <210> 627 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 627 ttcactggag tagactttta 20 <210> 628 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 628 cttataaggg aggtctggta 20 <210> 629 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 629 gcataattct taagggccct 20 <210> 630 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 630 ccacagaact tcttttaaaa 20 <210> 631 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 631 ggtgaccatg attttaacaa 20 <210> 632 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 632 aacagctgca tgacaatttt 20 <210> 633 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 633 agaaacagaa tcagtgactt 20 <210> 634 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 634 cagattccag agaaaagcca 20 <210> 635 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 635 tgtgagaaga actctatcac 20 <210> 636 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 636 ctcacaaatc accactaaag 20 <210> 637 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 637 caacgagtgg ataaagaaac 20 <210> 638 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 638 ataaaactgg atcctcatct 20 <210> 639 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 639 attaaaactc tcagcaaaat 20 <210> 640 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 640 aaagactgaa agaacacaaa 20 <210> 641 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 641 tatctgctgc cttcaggaga 20 <210> 642 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 642 tttgaattaa cccaattcaa 20 <210> 643 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 643 tcttaattta caacagagga 20 <210> 644 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 644 agaaaagtga caggcttccc 20 <210> 645 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 645 atgttccttg aagatcccaa 20 <210> 646 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 646 atgaataaca cttgccacaa 20 <210> 647 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 647 gtatgtttat cacagcacag 20 <210> 648 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 648 aaacactgca atattaggtt 20 <210> 649 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 649 gattggtgct tttcaaactg 20 <210> 650 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 650 atttgtaaga caaacatgaa 20 <210> 651 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 651 tcacatgact atgttctggc 20 <210> 652 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 652 agtcctgtcc acactattaa 20 <210> 653 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 653 ctgggctctg cctgctgaac 20 <210> 654 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 654 aaaaccctta agtatttcct 20 <210> 655 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 655 ctctgtttca aaccccccag 20 <210> 656 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 656 ggacagaaca ccaatcacaa 20 <210> 657 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 657 acctaccctt caaagtcacg 20 <210> 658 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 658 ttcagttccc aggaggctta 20 <210> 659 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 659 ttttgcaatg tctagcaatt 20 <210> 660 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 660 attaagatca gaaaatatta 20 <210> 661 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 661 ttaatgagat attttgcacc 20 <210> 662 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 662 gagaggttaa gtaaatctcc 20 <210> 663 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 663 cagactcaaa tttgaaaatt 20 <210> 664 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 664 gataaggcaa taatacagcc 20 <210> 665 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 665 atcatttgcc aatttctgtg 20 <210> 666 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 666 caagaagaaa agatgcaaaa 20 <210> 667 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 667 aatttatttc cttcctatga 20 <210> 668 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 668 ttttggaaat gtgagaaacg 20 <210> 669 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 669 aaacacatga gaaaagatga 20 <210> 670 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 670 tgttggctca gtgggaatga 20 <210> 671 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 671 tgaacaggtt tgcatttctc 20 <210> 672 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 672 tcctaggtga acaggctatg 20 <210> 673 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 673 ccctaatcag gctgaaataa 20 <210> 674 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 674 agggccagta aggtttgctt 20 <210> 675 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 675 agcctgaatt ctgagctctg 20 <210> 676 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 676 agaggatctc agctgcaatt 20 <210> 677 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 677 gaaaatccct gctcaagtgc 20 <210> 678 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 678 tgcctgatat tgtaattctt 20 <210> 679 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 679 ctcatacagt gaagtcttca 20 <210> 680 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 680 ctcactaagc ttgattcact 20 <210> 681 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 681 gatacagaaa tcccagtgac 20 <210> 682 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 682 tgtgcttggg tgtacaggca 20 <210> 683 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 683 tcaagcactt acatcatatg 20 <210> 684 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 684 agggttagtt attacactta 20 <210> 685 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 685 aggcttcatg tgaggtaaca 20 <210> 686 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 686 tgaaagctta gtacaagaag 20 <210> 687 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 687 ctctcctctt ggagatccag 20 <210> 688 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 688 gctgagattt ctctcctctt 20 <210> 689 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 689 cttttgctga gatttctctc 20 <210> 690 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 690 gaacatatgt ccatagaatg 20 <210> 691 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 691 gaacaggcta tgtaatcaaa 20 <210> 692 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 692 tttttattac tgtgcaaacc 20 <210> 693 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 693 actgagggtg gaaatggaaa 20 <210> 694 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 694 atgccatact tttcatttca 20 <210> 695 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 695 tctttaaaga tttcctatgc 20 <210> 696 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 696 tcacaattaa attatgttta 20 <210> 697 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 697 tttgccatca ccaaacacca 20 <210> 698 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 698 tcagaatgct gaaggatggg 20 <210> 699 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 699 acaattgcag gagagaactg 20 <210> 700 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 700 gttcagtcac ctggaaagag 20 <210> 701 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 701 cggagttcag tcacctggaa 20 <210> 702 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 702 aatctaaagt tcaatgtcca 20 <210> 703 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 703 ccacctttgg gtgaatagca 20 <210> 704 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 704 caacatcaaa agtttccacc 20 <210> 705 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 705 aagcttctat caaccaactg 20 <210> 706 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 706 accattttct aataattcac 20 <210> 707 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 707 acctgcactt ggacaactga 20 <210> 708 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 708 gtcagtgctt tggtgatgta 20 <210> 709 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 709 tagaagcaca ggaactagag 20 <210> 710 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 710 tttaatttta ttagaagcac 20 <210> 711 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 711 gagcaagaat taagaaaatc 20 <210> 712 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 712 ctctgcagtc atgtacacaa 20 <210> 713 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 713 gcttggtttg tcaatccttt 20 <210> 714 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 714 gttctcaagc aggagccatt 20 <210> 715 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 715 agggtgatct tccaaaacaa 20 <210> 716 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 716 tctcctatgc ttcctttaat 20 <210> 717 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 717 gacataaata tgttcactga 20 <210> 718 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 718 ttactgagtg acagtacagt 20 <210> 719 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 719 ccaggcacca gcacaggcac 20 <210> 720 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 720 ttaatgtcag tagaaagctg 20 <210> 721 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 721 gcaggtggaa agaagatgtc 20 <210> 722 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 722 gccagggtct ttacaaagtt 20 <210> 723 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 723 cattaccttt gtacatgtac 20 <210> 724 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 724 gaagcaactt ctctgaggtc 20 <210> 725 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 725 gcctggcaag aagggccctt 20 <210> 726 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 726 acacatgttt ttaaatttat 20 <210> 727 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 727 tcacaatgca ctaaaagaaa 20 <210> 728 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 728 tcccaatgac ttactgtaga 20 <210> 729 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 729 taagcattta tggaggaatg 20 <210> 730 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 730 tgaggtgggt ggccaacagg 20 <210> 731 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 731 gtttttcatt ttgattgcag 20 <210> 732 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 732 agctcaagtg tttttcattt 20 <210> 733 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 733 caatgtcaca gctgtttcct 20 <210> 734 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 734 gaactttgga ggcttttaga 20 <210> 735 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 735 tgtatgcccc aaactcccat 20 <210> 736 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 736 acacaaataa gggaataata 20 <210> 737 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 737 tagttcagcc actatggaaa 20 <210> 738 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 738 ctccaaattc cagtcctagg 20 <210> 739 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 739 agttggcact gctatatcag 20 <210> 740 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 740 ggccttagat tgtaagtttt 20 <210> 741 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 741 ttttagtatt attgtaggaa 20 <210> 742 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 742 tttcattaat gaaacctgat 20 <210> 743 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 743 ccctcagctg cctcttcaat 20 <210> 744 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 744 tattgtatcc tggcccctaa 20 <210> 745 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 745 agaacaagag cctagaagta 20 <210> 746 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 746 gtgactatgt cactgaattt 20 <210> 747 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 747 gccctaccca gcagcctgtg 20 <210> 748 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 748 caaacataaa gagagttcca 20 <210> 749 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 749 ctttaaatga agtagagctc 20 <210> 750 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 750 ctgttcaaag aatgcaggcc 20 <210> 751 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 751 gtctagccta acagagatat 20 <210> 752 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 752 aaagagtgat gtctagccta 20 <210> 753 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 753 cacttcttac tcctttgagg 20 <210> 754 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 754 ttccacaaga aactcagttt 20 <210> 755 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 755 agaaatgcca aagatagctc 20 <210> 756 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 756 agcagaggat ctcagctgca 20 <210> 757 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 757 aatccctgct caagtgctac 20 <210> 758 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 758 aaatccctgc tcaagtgcta 20 <210> 759 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 759 aaaatccctg ctcaagtgct 20 <210> 760 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 760 agaaaatccc tgctcaagtg 20 <210> 761 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 761 aagaaaatcc ctgctcaagt 20 <210> 762 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 762 caagaaaatc cctgctcaag 20 <210> 763 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 763 ctgatattgt aattcttggt 20 <210> 764 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 764 cctgatattg taattcttgg 20 <210> 765 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 765 gcctgatatt gtaattcttg 20 <210> 766 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 766 atgcctgata ttgtaattct 20 <210> 767 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 767 aatgcctgat attgtaattc 20 <210> 768 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 768 caatgcctga tattgtaatt 20 <210> 769 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 769 aattatgtgc tttgcctgca 20 <210> 770 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 770 caattatgtg ctttgcctgc 20 <210> 771 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 771 tcaattatgt gctttgcctg 20 <210> 772 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 772 tgtcaattat gtgctttgcc 20 <210> 773 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 773 atgtcaatta tgtgctttgc 20 <210> 774 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 774 gatgtcaatt atgtgctttg 20 <210> 775 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 775 ctggtgactc tgcctgatga 20 <210> 776 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 776 gctggtgact ctgcctgatg 20 <210> 777 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 777 tgctggtgac tctgcctgat 20 <210> 778 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 778 gctgctggtg actctgcctg 20 <210> 779 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 779 ggctgctggt gactctgcct 20 <210> 780 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 780 tggctgctgg tgactctgcc 20 <210> 781 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 781 gctgaaggat gggcatccag 20 <210> 782 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 782 tgctgaagga tgggcatcca 20 <210> 783 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 783 atgctgaagg atgggcatcc 20 <210> 784 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 784 gaatgctgaa ggatgggcat 20 <210> 785 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 785 agaatgctga aggatgggca 20 <210> 786 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 786 cagaatgctg aaggatgggc 20 <210> 787 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 787 tccagtagtc aatattattt 20 <210> 788 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 788 atccagtagt caatattatt 20 <210> 789 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 789 tatccagtag tcaatattat 20 <210> 790 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 790 gttatccagt agtcaatatt 20 <210> 791 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 791 ggttatccag tagtcaatat 20 <210> 792 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 792 tggttatcca gtagtcaata 20 <210> 793 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 793 caacttgagg acaataagag 20 <210> 794 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 794 tcaacttgag gacaataaga 20 <210> 795 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 795 ctcaacttga ggacaataag 20 <210> 796 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 796 aactcaactt gaggacaata 20 <210> 797 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 797 taactcaact tgaggacaat 20 <210> 798 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 798 ataactcaac ttgaggacaa 20 <210> 799 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 799 caggaagaaa ggaaccttag 20 <210> 800 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 800 ccaggaagaa aggaacctta 20 <210> 801 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 801 accaggaaga aaggaacctt 20 <210> 802 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 802 agaccaggaa gaaaggaacc 20 <210> 803 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 803 tagaccagga agaaaggaac 20 <210> 804 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 804 atagaccagg aagaaaggaa 20 <210> 805 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 805 tacaatgcac aggacacgcc 20 <210> 806 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 806 ctacaatgca caggacacgc 20 <210> 807 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 807 gctacaatgc acaggacacg 20 <210> 808 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 808 atgctacaat gcacaggaca 20 <210> 809 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 809 tatgctacaa tgcacaggac 20 <210> 810 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 810 atatgctaca atgcacagga 20 <210> 811 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 811 ctgatattta ttgctgtacg 20 <210> 812 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 812 ctctgatatt tattgctgta 20 <210> 813 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 813 tctctgatat ttattgctgt 20 <210> 814 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 814 gtctctgata tttattgctg 20 <210> 815 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 815 ccagaagaat tacccatgca 20 <210> 816 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 816 tccagaagaa ttacccatgc 20 <210> 817 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 817 ttccagaaga attacccatg 20 <210> 818 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 818 tcttccagaa gaattaccca 20 <210> 819 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 819 atcttccaga agaattaccc 20 <210> 820 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 820 catcttccag aagaattacc 20 <210> 821 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 821 tttctgcagt atcctagcct 20 <210> 822 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 822 gtttctgcag tatcctagcc 20 <210> 823 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 823 agtttctgca gtatcctagc 20 <210> 824 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 824 tcagtttctg cagtatccta 20 <210> 825 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 825 ttcagtttct gcagtatcct 20 <210> 826 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 826 tttcagtttc tgcagtatcc 20 <210> 827 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 827 gtttccattt tcttgattcc 20 <210> 828 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 828 tgtttccatt ttcttgattc 20 <210> 829 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 829 gtgtttccat tttcttgatt 20 <210> 830 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 830 tggtgtttcc attttcttga 20 <210> 831 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 831 atggtgtttc cattttcttg 20 <210> 832 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 832 aatggtgttt ccattttctt 20 <210> 833 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 833 aacccatttc atccatttaa 20 <210> 834 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 834 gaacccattt catccattta 20 <210> 835 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 835 ggaacccatt tcatccattt 20 <210> 836 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 836 taggaaccca tttcatccat 20 <210> 837 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 837 gtaggaaccc atttcatcca 20 <210> 838 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 838 ggtaggaacc catttcatcc 20 <210> 839 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 839 tgagggattg cctcagtagc 20 <210> 840 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 840 ttgagggatt gcctcagtag 20 <210> 841 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 841 tttgagggat tgcctcagta 20 <210> 842 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 842 cctttgaggg attgcctcag 20 <210> 843 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 843 tcctttgagg gattgcctca 20 <210> 844 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 844 ctcctttgag ggattgcctc 20 <210> 845 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 845 aacttaggac ttgggacatt 20 <210> 846 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 846 taacttagga cttgggacat 20 <210> 847 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 847 ctaacttagg acttgggaca 20 <210> 848 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 848 cactaactta ggacttggga 20 <210> 849 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 849 tcactaactt aggacttggg 20 <210> 850 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 850 gtcactaact taggacttgg 20 <210> 851 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 851 tgggctagat caggattggt 20 <210> 852 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 852 atgggctaga tcaggattgg 20 <210> 853 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 853 catgggctag atcaggattg 20 <210> 854 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 854 accatgggct agatcaggat 20 <210> 855 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 855 taccatgggc tagatcagga 20 <210> 856 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 856 ctaccatggg ctagatcagg 20 <210> 857 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 857 atgagcttag cagtcactta 20 <210> 858 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 858 catgagctta gcagtcactt 20 <210> 859 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 859 ccatgagctt agcagtcact 20 <210> 860 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 860 gtctcagcaa acctgggata 20 <210> 861 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 861 tgtctcagca aacctgggat 20 <210> 862 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 862 atgtctcagc aaacctggga 20 <210> 863 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 863 gaatgtctca gcaaacctgg 20 <210> 864 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 864 ggaatgtctc agcaaacctg 20 <210> 865 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 865 aggaatgtct cagcaaacct 20 <210> 866 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 866 tacagacata gctctaacct 20 <210> 867 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 867 atacagacat agctctaacc 20 <210> 868 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 868 gatacagaca tagctctaac 20 <210> 869 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 869 tggatacaga catagctcta 20 <210> 870 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 870 ctggatacag acatagctct 20 <210> 871 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 871 gctggataca gacatagctc 20 <210> 872 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 872 acactgtttg tgagggtcaa 20 <210> 873 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 873 aacactgttt gtgagggtca 20 <210> 874 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 874 caacactgtt tgtgagggtc 20 <210> 875 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 875 aacaacactg tttgtgaggg 20 <210> 876 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 876 aaacaacact gtttgtgagg 20 <210> 877 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 877 caaacaacac tgtttgtgag 20 <210> 878 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 878 ttcaagttta ggatctgcag 20 <210> 879 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 879 cttcaagttt aggatctgca 20 <210> 880 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 880 gcttcaagtt taggatctgc 20 <210> 881 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 881 gggcttcaag tttaggatct 20 <210> 882 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 882 agggcttcaa gtttaggatc 20 <210> 883 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 883 cagggcttca agtttaggat 20 <210> 884 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 884 tgtggcttta attcactaat 20 <210> 885 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 885 atgtggcttt aattcactaa 20 <210> 886 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 886 tatgtggctt taattcacta 20 <210> 887 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 887 ggtatgtggc tttaattcac 20 <210> 888 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 888 tggtatgtgg ctttaattca 20 <210> 889 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 889 gtggtatgtg gctttaattc 20 <210> 890 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 890 tctgtgttca gttgcatcac 20 <210> 891 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 891 ttctgtgttc agttgcatca 20 <210> 892 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 892 gttctgtgtt cagttgcatc 20 <210> 893 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 893 gtactcatga ggaggcactt 20 <210> 894 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 894 ggtactcatg aggaggcact 20 <210> 895 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 895 tggtactcat gaggaggcac 20 <210> 896 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 896 attggtactc atgaggaggc 20 <210> 897 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 897 aattggtact catgaggagg 20 <210> 898 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 898 caattggtac tcatgaggag 20 <210> 899 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 899 aaactctgca actccaaccc 20 <210> 900 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 900 gaaactctgc aactccaacc 20 <210> 901 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 901 ggaaactctg caactccaac 20 <210> 902 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 902 atggaaactc tgcaactcca 20 <210> 903 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 903 catggaaact ctgcaactcc 20 <210> 904 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 904 tcatggaaac tctgcaactc 20 <210> 905 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 905 acatctggat gtgaggctcg 20 <210> 906 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 906 cacatctgga tgtgaggctc 20 <210> 907 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 907 gtcacatctg gatgtgaggc 20 <210> 908 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 908 tgtcacatct ggatgtgagg 20 <210> 909 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 909 ctgtcacatc tggatgtgag 20 <210> 910 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 910 gtcaattatg tgctttgcct 20 <210> 911 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 911 acattcaaaa ttcttccttg 20 <210> 912 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 912 atcctgcata tattttattg 20 <210> 913 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 913 ctgctggtga ctctgcctga 20 <210> 914 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 914 aatgctgaag gatgggcatc 20 <210> 915 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 915 ttatccagta gtcaatatta 20 <210> 916 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 916 tctcatgtta aagttcttaa 20 <210> 917 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 917 tgcacttgga caactgatag 20 <210> 918 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 918 actcaacttg aggacaataa 20 <210> 919 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 919 gaccaggaag aaaggaacct 20 <210> 920 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 920 tgctacaatg cacaggacac 20 <210> 921 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 921 tctgatattt attgctgtac 20 <210> 922 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 922 atgcttcctt taataaatgt 20 <210> 923 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 923 aacatttaga acctaggaga 20 <210> 924 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 924 caagcttgca agtaggaaaa 20 <210> 925 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 925 ccaggctgtt catgccaagg 20 <210> 926 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 926 cctgccaagg gcaagccagg 20 <210> 927 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 927 tttcacctgg tgactggaag 20 <210> 928 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 928 attttctacc atcaaagaga 20 <210> 929 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 929 gattaagttt tctttaaaaa 20 <210> 930 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 930 cttccagaag aattacccat 20 <210> 931 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 931 cagtttctgc agtatcctag 20 <210> 932 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 932 tattttgaaa atgagattca 20 <210> 933 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 933 gtggcccgag taaagataaa 20 <210> 934 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 934 cctgtcaatc ctcttatatg 20 <210> 935 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 935 ggtgtttcca ttttcttgat 20 <210> 936 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 936 acagggtcaa aagttcactt 20 <210> 937 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 937 taggaaagct gagagaatcc 20 <210> 938 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 938 agcatatgaa aaaatactca 20 <210> 939 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 939 cttcagaaat cagcatctga 20 <210> 940 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 940 ttacaagtga cagtgtttgt 20 <210> 941 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 941 atcagaccct gaagaattta 20 <210> 942 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 942 aggaacccat ttcatccatt 20 <210> 943 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 943 cacattggta acttaaagtt 20 <210> 944 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 944 tattatctga ctcatttctg 20 <210> 945 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 945 aaataagaca aagaaaattc 20 <210> 946 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 946 ttttaaaaat aaccaattca 20 <210> 947 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 947 ctttgaggga ttgcctcagt 20 <210> 948 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 948 acagtcctca tgaacagatt 20 <210> 949 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 949 actatcatta ataatattgt 20 <210> 950 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 950 atctagattt gccttataag 20 <210> 951 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 951 tggttgagga agacagtctc 20 <210> 952 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 952 tggctcataa cttccttagc 20 <210> 953 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 953 actaacttag gacttgggac 20 <210> 954 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 954 cttatagcat tactaagtgg 20 <210> 955 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 955 tggtggcagg agagagggaa 20 <210> 956 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 956 tttgccagga aatcttgaaa 20 <210> 957 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 957 ataacttttc tctgaaattt 20 <210> 958 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 958 ccatgggcta gatcaggatt 20 <210> 959 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 959 tgagcttagc agtcacttag 20 <210> 960 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 960 aatgtctcag caaacctggg 20 <210> 961 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 961 ggatacagac atagctctaa 20 <210> 962 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 962 acaacactgt ttgtgagggt 20 <210> 963 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 963 tctattttct aatagctgtt 20 <210> 964 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 964 ggccccacct ctgaccttca 20 <210> 965 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 965 tggtaaagct agaaaaaaaa 20 <210> 966 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 966 aagtggtaaa tatgatcaca 20 <210> 967 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 967 ggcttcaagt ttaggatctg 20 <210> 968 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 968 ttgttgacac tctcttttgg 20 <210> 969 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 969 gtatgtggct ttaattcact 20 <210> 970 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 970 aattagttgt tttggcaaat 20 <210> 971 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 971 ctgtgttcag ttgcatcacg 20 <210> 972 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 972 aatgtggaag tttcctaaca 20 <210> 973 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 973 ttggtactca tgaggaggca 20 <210> 974 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 974 tttctctgtg tttaaaattg 20 <210> 975 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 975 gtaaagcaca atgaacaaaa 20 <210> 976 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 976 atcacagatc tttgctacaa 20 <210> 977 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 977 tcctgccttt ctgaaccaaa 20 <210> 978 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 978 tggaaactct gcaactccaa 20 <210> 979 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 979 acacagtagg gaacaatttt 20 <210> 980 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 980 agacagatgg tgaaatgatg 20 <210> 981 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 981 aaacagaaag agaagaaaac 20 <210> 982 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 982 cttagataaa tacttcaaga 20 <210> 983 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 983 agccacttct tttacaacct 20 <210> 984 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 984 tcacatctgg atgtgaggct 20 <210> 985 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 985 gactgaaact taaaggtggg 20 <210> 986 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 986 aaagatgtgc aatcatctaa 20 <210> 987 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 987 gctggtgact ctgcctg 17 <210> 988 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 988 tgctggtgac tctgcct 17 <210> 989 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 989 ctgctggtga ctctgcc 17 <210> 990 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 990 agtagtcaat attattt 17 <210> 991 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 991 cagtagtcaa tattatt 17 <210> 992 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 992 ccagtagtca atattat 17 <210> 993 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 993 cctttgggtg aatagca 17 <210> 994 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 994 acctttgggt gaatagc 17 <210> 995 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 995 cacctttggg tgaatag 17 <210> 996 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 996 caacttgagg acaataa 17 <210> 997 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 997 tcaacttgag gacaata 17 <210> 998 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 998 ctcaacttga ggacaat 17 <210> 999 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 999 caggaagaaa ggaacct 17 <210> 1000 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1000 ccaggaagaa aggaacc 17 <210> 1001 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1001 accaggaaga aaggaac 17 <210> 1002 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1002 tgcagtcatg tacacaa 17 <210> 1003 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1003 ctgcagtcat gtacaca 17 <210> 1004 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1004 tctgcagtca tgtacac 17 <210> 1005 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1005 tggtttgtca atccttt 17 <210> 1006 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1006 ttggtttgtc aatcctt 17 <210> 1007 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1007 cttggtttgt caatcct 17 <210> 1008 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1008 tacaatgcac aggacac 17 <210> 1009 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1009 ctacaatgca caggaca 17 <210> 1010 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1010 gctacaatgc acaggac 17 <210> 1011 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1011 gatatttatt gctgtac 17 <210> 1012 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1012 tgatatttat tgctgta 17 <210> 1013 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1013 ctgatattta ttgctgt 17 <210> 1014 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1014 agggtcttta caaagtt 17 <210> 1015 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1015 cagggtcttt acaaagt 17 <210> 1016 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1016 ccagggtctt tacaaag 17 <210> 1017 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1017 ttctgcagta tcctagc 17 <210> 1018 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1018 tttctgcagt atcctag 17 <210> 1019 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1019 gtttctgcag tatccta 17 <210> 1020 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1020 agtttctgca gtatcct 17 <210> 1021 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1021 cagtttctgc agtatcc 17 <210> 1022 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1022 caaattccag tcctagg 17 <210> 1023 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1023 ccaaattcca gtcctag 17 <210> 1024 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1024 tccaaattcc agtccta 17 <210> 1025 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1025 aacccatttc atccatt 17 <210> 1026 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1026 gaacccattt catccat 17 <210> 1027 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1027 ggaacccatt tcatcca 17 <210> 1028 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1028 gcttcatgtc tttctag 17 <210> 1029 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1029 tgcttcatgt ctttcta 17 <210> 1030 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1030 gtgcttcatg tctttct 17 <210> 1031 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1031 tgagcttagc agtcact 17 <210> 1032 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1032 catgagctta gcagtca 17 <210> 1033 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1033 tacagacata gctctaa 17 <210> 1034 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1034 atacagacat agctcta 17 <210> 1035 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1035 gatacagaca tagctct 17 <210> 1036 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1036 tgtggcttta attcact 17 <210> 1037 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1037 atgtggcttt aattcac 17 <210> 1038 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1038 tatgtggctt taattca 17 <210> 1039 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1039 tgttcagttg catcacg 17 <210> 1040 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1040 gtgttcagtt gcatcac 17 <210> 1041 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1041 tgtgttcagt tgcatca 17 <210> 1042 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1042 catctggatg tgaggct 17 <210> 1043 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1043 acatctggat gtgaggc 17 <210> 1044 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1044 cacatctgga tgtgagg 17 <210> 1045 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1045 tcaggtaatt tctggaa 17 <210> 1046 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1046 ctcaggtaat ttctgga 17 <210> 1047 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1047 tctcaggtaa tttctgg 17 <210> 1048 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1048 ttgcttattt acctggg 17 <210> 1049 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1049 tttgcttatt tacctgg 17 <210> 1050 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1050 ttttgcttat ttacctg 17 <210> 1051 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1051 atgatgttac tactact 17 <210> 1052 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1052 aatgatgtta ctactac 17 <210> 1053 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1053 caatgatgtt actacta 17 <210> 1054 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1054 cccctagagc aatggtc 17 <210> 1055 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1055 ccccctagag caatggt 17 <210> 1056 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1056 tccccctaga gcaatgg 17 <210> 1057 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1057 tcaattgcag atgctct 17 <210> 1058 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1058 ctcaattgca gatgctc 17 <210> 1059 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1059 gctcaattgc agatgct 17 <210> 1060 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1060 agctcaattg cagatgc 17 <210> 1061 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1061 gtatattcag tccaagg 17 <210> 1062 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1062 agtatattca gtccaag 17 <210> 1063 <211> 17 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1063 cagtatattc agtccaa 17 <210> 1064 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1064 gagtatttca ggctggaaaa 20 <210> 1065 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1065 gtaactcagg aatggaaaac 20 <210> 1066 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1066 agtaactcag gaatggaaaa 20 <210> 1067 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1067 aagtaactca ggaatggaaa 20 <210> 1068 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1068 gagatttcaa ataaatctca 20 <210> 1069 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1069 tgagatttca aataaatctc 20 <210> 1070 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1070 gtgagatttc aaataaatct 20 <210> 1071 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1071 tgtgagattt caaataaatc 20 <210> 1072 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1072 ttgtgagatt tcaaataaat 20 <210> 1073 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1073 tttgtgagat ttcaaataaa 20 <210> 1074 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1074 ctttgtgaga tttcaaataa 20 <210> 1075 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1075 actttgtgag atttcaaata 20 <210> 1076 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1076 cactttgtga gatttcaaat 20 <210> 1077 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1077 agtatttcag gctggaaaaa 20 <210> 1078 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1078 tgagtatttc aggctggaaa 20 <210> 1079 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1079 tctgagtatt tcaggctgga 20 <210> 1080 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1080 atctgagtat ttcaggctgg 20 <210> 1081 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1081 tatctgagta tttcaggctg 20 <210> 1082 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1082 ttttgtgtta tgccttgagg 20 <210> 1083 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1083 tttttgtgtt atgccttgag 20 <210> 1084 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1084 atttttgtgt tatgccttga 20 <210> 1085 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1085 atatttttgt gttatgcctt 20 <210> 1086 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1086 aatatttttg tgttatgcct 20 <210> 1087 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1087 aaatattttt gtgttatgcc 20 <210> 1088 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1088 ttgcttattt acctgggtaa 20 <210> 1089 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1089 tttgcttatt tacctgggta 20 <210> 1090 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1090 ttttgcttat ttacctgggt 20 <210> 1091 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1091 ccttttgctt atttacctgg 20 <210> 1092 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1092 gccttttgct tatttacctg 20 <210> 1093 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1093 tgccttttgc ttatttacct 20 <210> 1094 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1094 atgatgttac tactactcaa 20 <210> 1095 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1095 aatgatgtta ctactactca 20 <210> 1096 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1096 caatgatgtt actactactc 20 <210> 1097 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1097 tccaatgatg ttactactac 20 <210> 1098 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1098 ttccaatgat gttactacta 20 <210> 1099 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1099 attccaatga tgttactact 20 <210> 1100 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1100 cccctagagc aatggtctag 20 <210> 1101 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1101 ccccctagag caatggtcta 20 <210> 1102 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1102 tccccctaga gcaatggtct 20 <210> 1103 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1103 tatcccccta gagcaatggt 20 <210> 1104 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1104 atatccccct agagcaatgg 20 <210> 1105 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1105 aatatccccc tagagcaatg 20 <210> 1106 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1106 gctcacattt ggaagacagt 20 <210> 1107 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1107 ggctcacatt tggaagacag 20 <210> 1108 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1108 aggctcacat ttggaagaca 20 <210> 1109 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1109 agaggctcac atttggaaga 20 <210> 1110 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1110 tagaggctca catttggaag 20 <210> 1111 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1111 ttagaggctc acatttggaa 20 <210> 1112 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1112 ctcaattgca gatgctctga 20 <210> 1113 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1113 gctcaattgc agatgctctg 20 <210> 1114 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1114 agctcaattg cagatgctct 20 <210> 1115 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1115 aaagctcaat tgcagatgct 20 <210> 1116 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1116 taaagctcaa ttgcagatgc 20 <210> 1117 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1117 ataaagctca attgcagatg 20 <210> 1118 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1118 gtgagtccat taaacctctt 20 <210> 1119 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1119 tgtgagtcca ttaaacctct 20 <210> 1120 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1120 actgtgagtc cattaaacct 20 <210> 1121 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1121 aactgtgagt ccattaaacc 20 <210> 1122 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1122 gaactgtgag tccattaaac 20 <210> 1123 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1123 atattgaaag gcccatcaaa 20 <210> 1124 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1124 aatattgaaa ggcccatcaa 20 <210> 1125 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1125 aaatattgaa aggcccatca 20 <210> 1126 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1126 gaaaatattg aaaggcccat 20 <210> 1127 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1127 ggaaaatatt gaaaggccca 20 <210> 1128 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1128 aggaaaatat tgaaaggccc 20 <210> 1129 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1129 gtatattcag tccaaggatc 20 <210> 1130 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1130 agtatattca gtccaaggat 20 <210> 1131 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1131 cagtatattc agtccaagga 20 <210> 1132 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1132 aacagtatat tcagtccaag 20 <210> 1133 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1133 aaacagtata ttcagtccaa 20 <210> 1134 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1134 aaaacagtat attcagtcca 20 <210> 1135 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1135 tctattgttg ccacctttat 20 <210> 1136 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1136 ttctattgtt gccaccttta 20 <210> 1137 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1137 tttctattgt tgccaccttt 20 <210> 1138 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1138 agtttctatt gttgccacct 20 <210> 1139 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1139 cagtttctat tgttgccacc 20 <210> 1140 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1140 ccagtttcta ttgttgccac 20 <210> 1141 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1141 gcagaactga ttgcttactt 20 <210> 1142 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1142 aggtcataag attttcattt 20 <210> 1143 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1143 gcctctggcc ataaagaaat 20 <210> 1144 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1144 aaagtttaag aggcacccca 20 <210> 1145 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1145 gaataagcac aaaagtttaa 20 <210> 1146 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1146 gaaccaaata aacctctctt 20 <210> 1147 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1147 atgttgaaat ttgatcccca 20 <210> 1148 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1148 tgtgagagct cactcactat 20 <210> 1149 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1149 cttgtgagag ctcactcact 20 <210> 1150 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1150 acatggtggc aggagagagg 20 <210> 1151 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1151 ctagaaagaa actacctgag 20 <210> 1152 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1152 aacttcagtt gtaaaataat 20 <210> 1153 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1153 gaaaaggatt ttgagatttc 20 <210> 1154 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1154 cttagctgtc aaggcccttt 20 <210> 1155 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1155 tgtgcttcat gtctttctag 20 <210> 1156 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1156 cccttgaaca tgctatcctt 20 <210> 1157 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1157 cttgcaggga tgcatctcag 20 <210> 1158 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1158 tctcttgcac atctaatttc 20 <210> 1159 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1159 cttccagcac aacccatcac 20 <210> 1160 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1160 gtaactacat tccctttatc 20 <210> 1161 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1161 agtaactaca ttccctttat 20 <210> 1162 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1162 cagatagcac agggctaaaa 20 <210> 1163 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1163 agaatcagga atgtttgcct 20 <210> 1164 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1164 tgactcaatc atttagactt 20 <210> 1165 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1165 tcaacagtca atggacttgt 20 <210> 1166 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1166 aatttctact gctatgatgc 20 <210> 1167 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1167 atggttccaa atttctatct 20 <210> 1168 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1168 ctgtatggct ttaagtattc 20 <210> 1169 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1169 aacttatgaa ctgttcacca 20 <210> 1170 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1170 aataagcttg aagtctgaag 20 <210> 1171 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1171 tagttatcta actgcccaat 20 <210> 1172 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1172 ttctgcaaag cttcccagta 20 <210> 1173 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1173 acaacttcaa gcttcacata 20 <210> 1174 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1174 gaatcaatgt tctggcaaga 20 <210> 1175 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1175 cagcctttca gctgtgaaag 20 <210> 1176 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1176 aacaatgcca agaaatctat 20 <210> 1177 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1177 cccacagtaa caatgccaag 20 <210> 1178 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1178 ttttacctcc cagtgaaact 20 <210> 1179 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1179 taattgttga tccatgatgt 20 <210> 1180 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1180 gttggagaga caagtttaac 20 <210> 1181 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1181 agtcataaaa ttcaaattat 20 <210> 1182 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1182 ggccttgggc acactttctc 20 <210> 1183 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1183 aagtttttat tgaagttaat 20 <210> 1184 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1184 aagaaaaatt aggaagctag 20 <210> 1185 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1185 cagggagata agtttattca 20 <210> 1186 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1186 atttaataca cattggaata 20 <210> 1187 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1187 gtaggactat ttatgattcc 20 <210> 1188 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1188 cactctcttg ggctgttaag 20 <210> 1189 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1189 ttgtttgagt tccaaaagaa 20 <210> 1190 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1190 tttgccatga gacacacaat 20 <210> 1191 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1191 caccaaacct cagagacatg 20 <210> 1192 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1192 ccactgttaa gtgatgcatg 20 <210> 1193 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1193 ctctcaggta atttctggaa 20 <210> 1194 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1194 gctcctcaca atgacccttt 20 <210> 1195 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1195 gggactggca ctggtaattt 20 <210> 1196 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1196 ctaaccatta gttactgtat 20 <210> 1197 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1197 ggattttagg ttcttgctgt 20 <210> 1198 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1198 tgaatcatat actgatatca 20 <210> 1199 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1199 ttgaggtatt aaattttaaa 20 <210> 1200 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1200 agtttgtaat gtagtgattt 20 <210> 1201 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1201 aaatatttga tagctcacat 20 <210> 1202 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1202 agaaatattt gatagctcac 20 <210> 1203 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1203 ccacatttca aatgttctct 20 <210> 1204 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1204 gcaggaagag tggcatggac 20 <210> 1205 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1205 cacttatcca aatgcagaga 20 <210> 1206 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1206 caaggtaatg ggaggctagc 20 <210> 1207 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1207 atagtcaaag ctaaggatat 20 <210> 1208 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1208 gtaatttcat tcatgcttcc 20 <210> 1209 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1209 gtccacattc agctgtgtgt 20 <210> 1210 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1210 tcattcagga aattctgcta 20 <210> 1211 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1211 aacatgtctc attcaggaaa 20 <210> 1212 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1212 taacatgtct cattcaggaa 20 <210> 1213 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1213 agattcctca aattcagtga 20 <210> 1214 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1214 taagcggaaa aggagaaaag 20 <210> 1215 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1215 aaagcaagag aattcctaaa 20 <210> 1216 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1216 aatgaacctt taacttagta 20 <210> 1217 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1217 aaagctttgt ggataaagtt 20 <210> 1218 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1218 gaaggaaagg ttctgtggaa 20 <210> 1219 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1219 ctgagtattt caggctggaa 20 <210> 1220 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1220 ttgaattatc cctttaaaaa 20 <210> 1221 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1221 tttagaatgg tttggcatac 20 <210> 1222 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1222 gatatgtcca cattgattag 20 <210> 1223 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1223 attatttaag cttctacttt 20 <210> 1224 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1224 atacatggca attaaaagat 20 <210> 1225 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1225 tgagatagtg tgggaaatat 20 <210> 1226 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1226 tatttttgtg ttatgccttg 20 <210> 1227 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1227 ttattaacta gaatatgcct 20 <210> 1228 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1228 gattattcta tttttatttt 20 <210> 1229 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1229 aggaagagtg gcatggacat 20 <210> 1230 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1230 cttttgctta tttacctggg 20 <210> 1231 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1231 tttatattat taatatcatt 20 <210> 1232 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1232 ggtacatggc ttttaagtgg 20 <210> 1233 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1233 aatattggtc aggtttaaga 20 <210> 1234 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1234 atttcatctc tttcttagtt 20 <210> 1235 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1235 ccaatgatgt tactactact 20 <210> 1236 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1236 gttcccccaa ccccttggaa 20 <210> 1237 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1237 tataggaagt gagatgtatg 20 <210> 1238 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1238 attattctag aagaagattt 20 <210> 1239 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1239 atccccctag agcaatggtc 20 <210> 1240 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1240 gaggctcaca tttggaagac 20 <210> 1241 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1241 tacacaaatc caaggcagag 20 <210> 1242 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1242 aggaagagtg ggagtgttac 20 <210> 1243 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1243 gtccctgact aggcattttg 20 <210> 1244 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1244 aagctcaatt gcagatgctc 20 <210> 1245 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1245 ctgtgagtcc attaaacctc 20 <210> 1246 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1246 tgaaatgtgg ctagtgtgac 20 <210> 1247 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1247 aaaatattga aaggcccatc 20 <210> 1248 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1248 aatgtcaata gtgccctatt 20 <210> 1249 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1249 acagtatatt cagtccaagg 20 <210> 1250 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1250 tgtctattta agtttgttgc 20 <210> 1251 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1251 ttcaagtact gtcatgaata 20 <210> 1252 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1252 tttctttttc ttaaactaag 20 <210> 1253 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1253 gtttctattg ttgccacctt 20 <210> 1254 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1254 aaggccacat attatagtat 20 <210> 1255 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1255 acctgaacta ttaatttctt 20 <210> 1256 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1256 gaatgggctg agtagttgaa 20 <210> 1257 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1257 tgatgaacat tgctaatttg 20 <210> 1258 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1258 atcttgcctc gatgaaagtt 20 <210> 1259 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1259 ttaagtggca cagccatgat 20 <210> 1260 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1260 aatgagttaa gttggaacac 20 <210> 1261 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1261 tccttagtag aatgcctgga 20 <210> 1262 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1262 tatgtagaaa aataagctgg 20 <210> 1263 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1263 gccgaggcag gcacctgagt 20 <210> 1264 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1264 tggtacctat attgagaggt 20 <210> 1265 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1265 ttaaggaaaa atatagtata 20 <210> 1266 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1266 ttatttatgt gtcagggatg 20 <210> 1267 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1267 caaaagttaa gtgctttagg 20 <210> 1268 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1268 ttcatagatg tctaaggaat 20 <210> 1269 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1269 acctgtgatt tacctatttc 20 <210> 1270 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1270 tgcctagaaa accacataaa 20 <210> 1271 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1271 aaacatcctc aaaggtacct 20 <210> 1272 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1272 cttccctgag acacacacat 20 <210> 1273 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1273 cttcttcaat cttctcatac 20 <210> 1274 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1274 taccattttc catttagttt 20 <210> 1275 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1275 attggcatct ttttcagtgg 20 <210> 1276 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1276 tcaagctcac ggttggagac 20 <210> 1277 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1277 aaatgaaatc agtatgttga 20 <210> 1278 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1278 tgatttatca caaaggtgct 20 <210> 1279 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1279 aaaacagtag aaaagattaa 20 <210> 1280 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1280 ctacatcaca gcagtcagaa 20 <210> 1281 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1281 aaaagatgta agtgtgacat 20 <210> 1282 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1282 ttacaagaac tgctaaaggg 20 <210> 1283 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1283 ataaagaaaa agttaactga 20 <210> 1284 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1284 agataatata cttcttctat 20 <210> 1285 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1285 ccttcttcac atgtaaattg 20 <210> 1286 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1286 tttctatgta gcttgtggtt 20 <210> 1287 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1287 aggcagagtt tttattgata 20 <210> 1288 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1288 atagtcacca gcctaagcct 20 <210> 1289 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1289 agacttttag catgcttgac 20 <210> 1290 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1290 tttacagccc tacagttcta 20 <210> 1291 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1291 ccagagaacc tgactccaaa 20 <210> 1292 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1292 cagaagaaaa tattagacag 20 <210> 1293 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1293 tattatactt ctaaattccc 20 <210> 1294 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1294 taaaagcaag aaaaaggaac 20 <210> 1295 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1295 cctaatttat atgaacaaac 20 <210> 1296 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1296 tgcaatgcct tagcctaaaa 20 <210> 1297 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1297 caccaccatt attacactac 20 <210> 1298 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1298 aaataaatca gattattata 20 <210> 1299 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1299 cttagatctg tgctgtccaa 20 <210> 1300 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1300 gttagtgtta gattctttga 20 <210> 1301 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1301 catgctcacg gctgtgttac 20 <210> 1302 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1302 cccatcaaat actgagttct 20 <210> 1303 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1303 gaaagtagtg attaatgaga 20 <210> 1304 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1304 attaatcaac aagtggcatt 20 <210> 1305 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1305 tttaatttta gggtttagag 20 <210> 1306 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1306 cttgctacca ctagagcctt 20 <210> 1307 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1307 accactgact tatatcattt 20 <210> 1308 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1308 ttccccattg ctaattttgt 20 <210> 1309 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1309 tcctgaaact tagtagctgg 20 <210> 1310 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1310 tgtcttaaaa aggaataaaa 20 <210> 1311 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1311 cctataataa agtattgtct 20 <210> 1312 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1312 atgtaaaatg gtatagctac 20 <210> 1313 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1313 aaccctcaca cacttctgtt 20 <210> 1314 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1314 attctgcata agcagtgttt 20 <210> 1315 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1315 ttactaccct gaagaagaac 20 <210> 1316 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1316 aagacctata acttactacc 20 <210> 1317 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1317 tttcacaaga tttacttggt 20 <210> 1318 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1318 cagttgtgat tgtcaaccta 20 <210> 1319 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1319 aatcttgcct cgatgaaagt 20 <210> 1320 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1320 tggcctaaat gtatcagtta 20 <210> 1321 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1321 aggctttggg taaaatcttt 20 <210> 1322 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1322 tatgattttt aaagattaaa 20 <210> 1323 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1323 gtacagtgaa aaagatgtgt 20 <210> 1324 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1324 gacaggtatg aagcaaaaca 20 <210> 1325 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1325 tgagctgagg gtctttgccg 20 <210> 1326 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1326 aggctgagtt gtacacaaac 20 <210> 1327 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1327 atgaggaggc tgagttgtac 20 <210> 1328 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1328 tcataaagtg ggcccagctt 20 <210> 1329 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1329 actcctaatc cctcagtttt 20 <210> 1330 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1330 tttacatgca aggagctgag 20 <210> 1331 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1331 taatgccctt tctccctact 20 <210> 1332 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1332 cctgtttaga ttatcccaaa 20 <210> 1333 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1333 catgattcac agaatttctc 20 <210> 1334 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1334 agttagaaaa ctcaaagtat 20 <210> 1335 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1335 tcaaatgtac ttagcataag 20 <210> 1336 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1336 atatcaaatg tacttagcat 20 <210> 1337 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1337 aaagttcaga agagggaatg 20 <210> 1338 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1338 aattcccatc tgagtagttt 20 <210> 1339 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1339 gtcccctaat ttcaggctaa 20 <210> 1340 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1340 ctatgtcaaa tgaaacaaaa 20 <210> 1341 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1341 tgattatgct ttgtgataaa 20 <210> 1342 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1342 tccagctgac taggagggct 20 <210> 1343 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1343 cataccagtc tcctcgctca 20 <210> 1344 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1344 atataacaga atccaaccat 20 <210> 1345 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1345 tgcaaaatgg ccaaactaca 20 <210> 1346 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1346 tcttcctagc cacatgtgat 20 <210> 1347 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1347 taccatgctc tctaattgcc 20 <210> 1348 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1348 agtgatctgt gccaggctgc 20 <210> 1349 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1349 aagttacaga acagatatct 20 <210> 1350 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1350 gtattgtgaa aatagtactg 20 <210> 1351 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1351 aaacactatc aagctcacgg 20 <210> 1352 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1352 ttcaagaaaa gtcttcaaat 20 <210> 1353 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1353 ggatcatttc cccatgcatg 20 <210> 1354 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1354 atattatatt aagaaaaatg 20 <210> 1355 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1355 ctcccatgtt cattacttat 20 <210> 1356 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1356 catgacattg gtttgggcaa 20 <210> 1357 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1357 aatgttgttg ggaaaattgg 20 <210> 1358 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1358 agctgcagga tacaaagtca 20 <210> 1359 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1359 atatcctttc atgataaaaa 20 <210> 1360 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1360 atgggctaat atctctgata 20 <210> 1361 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1361 acattactaa taattagaga 20 <210> 1362 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1362 ataaaaacat atgaaagtat 20 <210> 1363 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1363 ttctgaatta aatctattag 20 <210> 1364 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1364 ttacattttt gcaaatttat 20 <210> 1365 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1365 tgaacagttg attaacaaag 20 <210> 1366 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1366 aagttattgg tttactagat 20 <210> 1367 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1367 ttggaaaagg tcctagaaaa 20 <210> 1368 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1368 catgacagaa acttcttaga 20 <210> 1369 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1369 ccatacttgc tgacaaatat 20 <210> 1370 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1370 ttggtttgtc aatcct 16 <210> 1371 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1371 ccgagcttcg cctctg 16 <210> 1372 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1372 cctccgagct tcgcct 16 <210> 1373 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1373 ggacctccga gcttcg 16 <210> 1374 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1374 cctgtaggac ctccga 16 <210> 1375 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1375 ccagtgccaa ggtcaa 16 <210> 1376 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1376 cacttgatcc tgccag 16 <210> 1377 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1377 cacttccaga aaaagc 16 <210> 1378 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1378 gtctctcgct caggtg 16 <210> 1379 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1379 aaagtctctc gctcag 16 <210> 1380 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1380 atgaaaaagt ctctcg 16 <210> 1381 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1381 tccttctggt atagaa 16 <210> 1382 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1382 caataaggta tccaga 16 <210> 1383 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1383 cttgatacaa taaggt 16 <210> 1384 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1384 ctagttagct tgatac 16 <210> 1385 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1385 gatctggttg cactat 16 <210> 1386 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1386 ggcaatgggt ggatct 16 <210> 1387 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1387 ccagttgagg gcaatg 16 <210> 1388 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1388 taaagtccag ttgagg 16 <210> 1389 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1389 tacatagagc acctca 16 <210> 1390 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1390 tgttacatag agcacc 16 <210> 1391 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1391 aagtgttaca tagagc 16 <210> 1392 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1392 cttcacatgt aaattg 16 <210> 1393 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1393 gagccatgga aagtag 16 <210> 1394 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1394 ccttccttga ggagat 16 <210> 1395 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1395 cttcacccct aggtta 16 <210> 1396 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1396 ccatccttca ccccta 16 <210> 1397 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1397 gtcgccatcc ttcacc 16 <210> 1398 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1398 ccagagtcgc catcct 16 <210> 1399 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1399 gtggctgagc aacctc 16 <210> 1400 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1400 cccttttaac ctctgt 16 <210> 1401 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1401 catcatgata aggtga 16 <210> 1402 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1402 tggataacac tgggct 16 <210> 1403 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1403 tctgcttgga taacac 16 <210> 1404 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1404 gaatatgggc agcttg 16 <210> 1405 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1405 agctgaatat gggcag 16 <210> 1406 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1406 ttgcttagct gaatat 16 <210> 1407 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1407 tggattgctt agctga 16 <210> 1408 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1408 acttggattg cttagc 16 <210> 1409 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1409 agtgaacttg gattgc 16 <210> 1410 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1410 ggcataaaag tcgatg 16 <210> 1411 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1411 ctgggcataa aagtcg 16 <210> 1412 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1412 ggaaaggacc acacta 16 <210> 1413 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1413 gagtgagacc atttcc 16 <210> 1414 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1414 gatgtgagga gccaca 16 <210> 1415 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1415 cttgatgtga ggagcc 16 <210> 1416 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1416 tcaaccttga tgtgag 16 <210> 1417 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1417 tgattcaacc ttgatg 16 <210> 1418 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1418 gtgtgattca accttg 16 <210> 1419 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1419 tatgtgtgat tcaacc 16 <210> 1420 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1420 ggcatctcag aacctg 16 <210> 1421 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1421 ggtatagtct gggaca 16 <210> 1422 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1422 tggaggtata gtctgg 16 <210> 1423 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1423 gaatggaggt atagtc 16 <210> 1424 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1424 tatgaatgga ggtata 16 <210> 1425 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1425 ctatatgaat ggaggt 16 <210> 1426 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1426 gtactatatg aatgga 16 <210> 1427 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1427 gggactgtac tatatg 16 <210> 1428 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1428 ttacattgca caatag 16 <210> 1429 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1429 tagccatgct tgaagt 16 <210> 1430 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1430 tgtgtagtgt aatata 16 <210> 1431 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1431 acagtgtgta gtgtaa 16 <210> 1432 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1432 gcagtacaca gtgtgt 16 <210> 1433 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1433 actgcagtac acagtg 16 <210> 1434 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1434 ttagactgta gttgct 16 <210> 1435 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1435 ccagctttag actgta 16 <210> 1436 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1436 taaaccagct ttagac 16 <210> 1437 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1437 aacattaaac cagctt 16 <210> 1438 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1438 actacaatca ttttag 16 <210> 1439 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1439 gattactaca atcatt 16 <210> 1440 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1440 aatgcagatt actaca 16 <210> 1441 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1441 tccaataatg cagatt 16 <210> 1442 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1442 gttgatctgt gcaaac 16 <210> 1443 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1443 tctacttctc ttagca 16 <210> 1444 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1444 gcttcttgta ccttat 16 <210> 1445 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1445 gatttgcttc aactta 16 <210> 1446 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1446 ggttataggc tgtgaa 16 <210> 1447 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1447 tctggttata ggctgt 16 <210> 1448 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1448 gtgtctggtt ataggc 16 <210> 1449 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1449 agtatgtgtc tggtta 16 <210> 1450 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1450 gggactgaaa accttg 16 <210> 1451 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1451 agtattcttc actgag 16 <210> 1452 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1452 gcgataaatg ggaaat 16 <210> 1453 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1453 gtctgcgata aatggg 16 <210> 1454 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1454 cctaaaaaag gtctgc 16 <210> 1455 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1455 cattaagctt gcttcc 16 <210> 1456 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1456 cacaactagt catact 16 <210> 1457 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1457 aactgccaga cacaac 16 <210> 1458 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1458 ataaactgcc agacac 16 <210> 1459 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1459 tatcaggaat ccaaga 16 <210> 1460 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1460 ttgataacag aagcac 16 <210> 1461 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1461 ttggtgtttg ataaca 16 <210> 1462 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1462 atgttggtgt ttgata 16 <210> 1463 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1463 ccgccactgt agcagc 16 <210> 1464 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1464 cgccaccgcc actgta 16 <210> 1465 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1465 gccgcccggg ctcagc 16 <210> 1466 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1466 cgccgccgcc cgggct 16 <210> 1467 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1467 gagagcgcgg gttcgc 16 <210> 1468 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1468 ctactgaccc cagttc 16 <210> 1469 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1469 tcactctact gacccc 16 <210> 1470 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1470 tcatgcggac tggtgg 16 <210> 1471 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1471 atgtgagcat ggaccc 16 <210> 1472 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1472 tcttgatatg tgagca 16 <210> 1473 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1473 ttcaagttgg tgagct 16 <210> 1474 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1474 tgcttccttc aagttg 16 <210> 1475 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1475 tgtaatttca ttcatg 16 <210> 1476 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1476 ccttttgcca agagca 16 <210> 1477 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1477 gatccttttg ccaaga 16 <210> 1478 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1478 gctagtaatg ttacat 16 <210> 1479 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1479 gcaacttgct agtaat 16 <210> 1480 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1480 tgtgcaactt gctagt 16 <210> 1481 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1481 ggatttcagt ttgaat 16 <210> 1482 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1482 ctcagagcct tggtag 16 <210> 1483 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1483 caaacgcgca aaagac 16 <210> 1484 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1484 gcccgcacaa acgcgc 16 <210> 1485 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1485 ggttaaagaa gttgct 16 <210> 1486 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1486 cccagtgaat tcagca 16 <210> 1487 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1487 gcgcccagtg aattca 16 <210> 1488 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1488 aagatgcgcc cagtga 16 <210> 1489 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1489 tgtaagatgc gcccag 16 <210> 1490 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1490 aattacttgt aagatg 16 <210> 1491 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1491 cccagaaggc acttgt 16 <210> 1492 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1492 ttgcagaaca aatctt 16 <210> 1493 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1493 catggaagat ttgcag 16 <210> 1494 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1494 ggtcatggaa gatttg 16 <210> 1495 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1495 gaccttggtc atggaa 16 <210> 1496 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1496 tgccaatcca aagagg 16 <210> 1497 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1497 gggtctgcca atccaa 16 <210> 1498 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1498 tccctgggtc tgccaa 16 <210> 1499 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1499 aagtgtgaat ttatct 16 <210> 1500 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1500 ggagatctca acaagg 16 <210> 1501 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1501 tcgcccatca ctcttc 16 <210> 1502 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1502 cctgtcgccc atcact 16 <210> 1503 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1503 tcacctgtcg cccatc 16 <210> 1504 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1504 ccatcacctg tcgccc 16 <210> 1505 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1505 tcaccatcac ctgtcg 16 <210> 1506 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1506 taatagttgt caccat 16 <210> 1507 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1507 ttcagatctt attaat 16 <210> 1508 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1508 ttgcaaattc agtctg 16 <210> 1509 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1509 cgttctcttg gaagta 16 <210> 1510 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1510 tcttgaataa atttcg 16 <210> 1511 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1511 aagctcactc ttcaat 16 <210> 1512 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1512 tccaagctca ctcttc 16 <210> 1513 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1513 gctcctgcca ctctgt 16 <210> 1514 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1514 atgggcaaag gcatct 16 <210> 1515 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1515 agtcttcccg gcgagg 16 <210> 1516 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1516 ccgccgctcc ctagcc 16 <210> 1517 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1517 gcccgcaact ccctgc 16 <210> 1518 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1518 cgcctcccca ggcgca 16 <210> 1519 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1519 gagtgtcttc ccaggc 16 <210> 1520 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1520 ctgaagactc cttgaa 16 <210> 1521 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1521 ggctagccaa gttgga 16 <210> 1522 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1522 tgactccagt cttacc 16 <210> 1523 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1523 attcattgtg gtcagc 16 <210> 1524 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1524 gaagtgggtt tttccc 16 <210> 1525 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1525 gccttggttc aggtga 16 <210> 1526 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1526 ccactgtagc agccgc 16 <210> 1527 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1527 taggtatttc agagcc 16 <210> 1528 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1528 gtccaggcag agttgt 16 <210> 1529 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1529 agccaaatgt tggtca 16 <210> 1530 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1530 gagggcgagt ttttcc 16 <210> 1531 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1531 gtggcattgg caagcc 16 <210> 1532 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1532 accccactgc accaag 16 <210> 1533 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1533 tccaagtact tgccaa 16 <210> 1534 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1534 agtgcctggc ctaagg 16 <210> 1535 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1535 gcgcttcttc cctagg 16 <210> 1536 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1536 catcttgccc agggat 16 <210> 1537 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1537 ccatcttgct ccaagt 16 <210> 1538 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1538 cttacatcct gtaggc 16 <210> 1539 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1539 cgcctcctgg tcctca 16 <210> 1540 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1540 ccctatgcac taccta 16 <210> 1541 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1541 gagggactgt ggtgct 16 <210> 1542 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1542 gcccaatatg tgccag 16 <210> 1543 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1543 gctctctcat cgctgg 16 <210> 1544 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1544 ctcaaggcta tgtgcc 16 <210> 1545 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1545 tccacatccc tcatgt 16 <210> 1546 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1546 aggactgaag gcccat 16 <210> 1547 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1547 gtgcgactta ccagct 16 <210> 1548 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1548 tcgctaaagc cacaca 16 <210> 1549 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1549 gctctggctg atggtc 16 <210> 1550 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1550 ttcccatgag gatttc 16 <210> 1551 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1551 ttgggcttaa gcacta 16 <210> 1552 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1552 gctagcacct agtcca 16 <210> 1553 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1553 cctctggcct acaaca 16 <210> 1554 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1554 acccctcatc agcacc 16 <210> 1555 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1555 ggccacccct gatcct 16 <210> 1556 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1556 gaagctccct tgccca 16 <210> 1557 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1557 agtgttgccc ctccaa 16 <210> 1558 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1558 gggtctccaa cctact 16 <210> 1559 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1559 gggatgtagg tttacc 16 <210> 1560 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1560 gcaaccgata tcacag 16 <210> 1561 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1561 tgccctggaa caaatt 16 <210> 1562 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1562 agtctaggag tagcta 16 <210> 1563 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1563 gctgttgtca agagac 16 <210> 1564 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1564 cacctagaca ctcagt 16 <210> 1565 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1565 gtcaagggat ccctgc 16 <210> 1566 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1566 tccccctggc actcca 16 <210> 1567 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1567 gcctggtaac tccatt 16 <210> 1568 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1568 gggctcacca actgtg 16 <210> 1569 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1569 ccacaggatc atatca 16 <210> 1570 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1570 ctccagcaga agtgtc 16 <210> 1571 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1571 agcccaactg ttgcct 16 <210> 1572 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1572 tgccaggcag ttgcca 16 <210> 1573 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1573 gccagtaagc accttg 16 <210> 1574 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1574 ctagcttccc agcccc 16 <210> 1575 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1575 tcaagcccag ctagca 16 <210> 1576 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1576 cctcacaggc cctaat 16 <210> 1577 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1577 acctgcttac atggta 16 <210> 1578 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1578 cctttgctag gaccca 16 <210> 1579 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1579 gggactgcca ccaagg 16 <210> 1580 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1580 gctagatgtt caggcc 16 <210> 1581 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1581 cctatggcca tgctga 16 <210> 1582 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1582 gtatgctagt tcccat 16 <210> 1583 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1583 ccctcataat cttggg 16 <210> 1584 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1584 gtccaaccac taccac 16 <210> 1585 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1585 acttgcagat agctga 16 <210> 1586 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1586 gcatgacccc actgcc 16 <210> 1587 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1587 gagggtcaca ttccct 16 <210> 1588 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1588 tctcttactg gtgggt 16 <210> 1589 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1589 gcccccttcc tggata 16 <210> 1590 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1590 cctcatgcga caccac 16 <210> 1591 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1591 agccctctgc ctgtaa 16 <210> 1592 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1592 ctcccagcta taggcg 16 <210> 1593 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1593 gctagctgcg caagga 16 <210> 1594 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1594 gcgcagcccg ctgcaa 16 <210> 1595 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1595 tgcatgatcc acccca 16 <210> 1596 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1596 gcttagtgct ggccca 16 <210> 1597 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1597 ccttccagtc ctcata 16 <210> 1598 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1598 atagtgtcaa ggccca 16 <210> 1599 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1599 aggccttagt caccca 16 <210> 1600 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1600 taaccaacct aaggga 16 <210> 1601 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1601 attctggtga tgccct 16 <210> 1602 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1602 gtgttcactg ccatga 16 <210> 1603 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1603 ggtagagcac actgcc 16 <210> 1604 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1604 ccactttaat gccacc 16 <210> 1605 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1605 gtcaaatgct gttggg 16 <210> 1606 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1606 catcccctat cagggt 16 <210> 1607 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1607 ctcgaatccc ttgagc 16 <210> 1608 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1608 gattccctcc cctaac 16 <210> 1609 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1609 atccatccat gtgctg 16 <210> 1610 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1610 gagcatgcct cagtgg 16 <210> 1611 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1611 cagaaggact gcctct 16 <210> 1612 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1612 acaatgctca acagcc 16 <210> 1613 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1613 gttggatctg gcatgc 16 <210> 1614 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1614 cggctgagag caaggg 16 <210> 1615 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1615 gagagggttc agcctg 16 <210> 1616 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1616 acttagttcc tagcca 16 <210> 1617 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1617 gtgaaccaga tgtgct 16 <210> 1618 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1618 ggagtgacag ctaagt 16 <210> 1619 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1619 aagtgttcag agccac 16 <210> 1620 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1620 aaccctgcca aggtac 16 <210> 1621 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1621 gatggtgagc actacc 16 <210> 1622 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1622 ggcaggatag gacaga 16 <210> 1623 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1623 gcaaagtgat gagcct 16 <210> 1624 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1624 ctatccacac cattcc 16 <210> 1625 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1625 ggatcatggg ccccta 16 <210> 1626 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1626 gtgaatttgc tgggcc 16 <210> 1627 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1627 gtgatgggcc caaggc 16 <210> 1628 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1628 tcctcagtcg gcttgc 16 <210> 1629 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1629 cagccttttg ccagat 16 <210> 1630 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1630 cctccctagg attacc 16 <210> 1631 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1631 acgccccaat cactca 16 <210> 1632 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1632 gcatgaccca ttatgt 16 <210> 1633 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1633 tccctccaag agctca 16 <210> 1634 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1634 gatgcctgtg gctgac 16 <210> 1635 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1635 ggctagcatg ttgcct 16 <210> 1636 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1636 taacccacta ggctgg 16 <210> 1637 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1637 tggcccaaaa ctaatc 16 <210> 1638 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1638 ggagcagtct ggcacc 16 <210> 1639 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1639 tattctgtgg gacaag 16 <210> 1640 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1640 gtgtctagtt ccagcc 16 <210> 1641 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1641 tactatcatg tagcgc 16 <210> 1642 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1642 tgcccttgta gtgaga 16 <210> 1643 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1643 tccccaacct acaagc 16 <210> 1644 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1644 gctctaggca tatgaa 16 <210> 1645 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1645 tacctccctt gtaggg 16 <210> 1646 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1646 ggttcccttg cagaga 16 <210> 1647 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1647 gtgccctctt catgcc 16 <210> 1648 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1648 cctgtgtgca actggc 16 <210> 1649 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1649 ctgagtcatt tgcctg 16 <210> 1650 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1650 ggccttagta ggccag 16 <210> 1651 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1651 gtccttgcag tcaacc 16 <210> 1652 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1652 gctgggccaa gtccat 16 <210> 1653 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1653 tagggcactt tttgcc 16 <210> 1654 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1654 gctgaggtcc ctctct 16 <210> 1655 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1655 ctttggtccc attgcc 16 <210> 1656 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1656 ggaacatgcc aagggc 16 <210> 1657 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1657 aggtggtctc ccttca 16 <210> 1658 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1658 tcccaaagct cccctc 16 <210> 1659 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1659 cctggcctag caagct 16 <210> 1660 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1660 tcttagccct gggcta 16 <210> 1661 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1661 gacttggact gggctc 16 <210> 1662 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1662 ggcctaggat ctagga 16 <210> 1663 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1663 gtcaggctag agggac 16 <210> 1664 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1664 ggaagttctc ccagcc 16 <210> 1665 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1665 cctgactgat gtacac 16 <210> 1666 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1666 ctctggccta gcctat 16 <210> 1667 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1667 ggctgctgtc agatgc 16 <210> 1668 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1668 tctcaggtgt aggcag 16 <210> 1669 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1669 ggtcactgag actggg 16 <210> 1670 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1670 acccactagc agctag 16 <210> 1671 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1671 cggatgaggc agttag 16 <210> 1672 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1672 tggtaggccc tctggc 16 <210> 1673 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1673 gtcacaaggt gggtgc 16 <210> 1674 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1674 gtcttgccct cacgga 16 <210> 1675 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1675 gcagtctgtg gactta 16 <210> 1676 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1676 tgctctctgg tcacac 16 <210> 1677 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1677 tatcccccag agccat 16 <210> 1678 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1678 aaggtgagag ggcact 16 <210> 1679 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1679 gttttaacct caccct 16 <210> 1680 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1680 ccttccactg accttc 16 <210> 1681 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1681 gacactagcc taagcc 16 <210> 1682 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1682 ggttagccct cagcct 16 <210> 1683 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1683 tatgaaggtt ggacca 16 <210> 1684 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1684 caaccagctc acctga 16 <210> 1685 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1685 gggctccaag gctctc 16 <210> 1686 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1686 agctgttaca tgccaa 16 <210> 1687 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1687 ggcccagagg ttatag 16 <210> 1688 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1688 gtccttagac ccctca 16 <210> 1689 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1689 gccctggcta gagaca 16 <210> 1690 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1690 catccagcag ctggac 16 <210> 1691 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1691 gactgaggtc atcaca 16 <210> 1692 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1692 ggccaggcac atcatg 16 <210> 1693 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1693 ggagctcatt gagcca 16 <210> 1694 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1694 gtgcccattg ctgtgt 16 <210> 1695 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1695 ccaagtgtgg cttcag 16 <210> 1696 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1696 ccacccttta tacgca 16 <210> 1697 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1697 cagtaacccc aaggga 16 <210> 1698 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1698 ccccacctta tatggg 16 <210> 1699 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1699 aggccctttt tacatg 16 <210> 1700 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1700 tcaataagtc cctagg 16 <210> 1701 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1701 ggcattgagt gactgc 16 <210> 1702 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1702 ataatgcctt ctcagc 16 <210> 1703 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1703 gtgaggcatt tagccc 16 <210> 1704 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1704 gctcttgtgt tgggta 16 <210> 1705 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1705 tgtgcaggag gtctca 16 <210> 1706 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1706 tggagagtct tgtctc 16 <210> 1707 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1707 gtgacccacc caagag 16 <210> 1708 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1708 gttgtagcta gtgttc 16 <210> 1709 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1709 gccttagttt gtgcca 16 <210> 1710 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1710 gccccagctg agaatt 16 <210> 1711 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1711 acaacaatcc agggtg 16 <210> 1712 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1712 ctcccctgga agtcac 16 <210> 1713 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1713 gccctcatgg ctcaag 16 <210> 1714 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1714 tcagcagata gggagc 16 <210> 1715 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1715 gaatgcggtg atcagg 16 <210> 1716 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1716 ctgagagaat tggccc 16 <210> 1717 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1717 aggcacattg ttacca 16 <210> 1718 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1718 gggaggcact agagaa 16 <210> 1719 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1719 tacagtaaca catccc 16 <210> 1720 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1720 gaagctcagc ctgatc 16 <210> 1721 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1721 cttgcctgac aaccta 16 <210> 1722 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1722 gcctacctgc ttttgc 16 <210> 1723 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1723 tttcccaacc acttag 16 <210> 1724 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1724 tctcctattt cagtta 16 <210> 1725 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1725 gggtgatgga tgaact 16 <210> 1726 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1726 acactgctgg tagtga 16 <210> 1727 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1727 acccaactag cctgtc 16 <210> 1728 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1728 gagacctgct gcctga 16 <210> 1729 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1729 acatctcttg ggaggt 16 <210> 1730 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1730 acatagtacc cctcca 16 <210> 1731 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1731 ctctcaagta cctgcc 16 <210> 1732 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1732 tttgtaccca accccc 16 <210> 1733 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1733 aggcccacat aaatgc 16 <210> 1734 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1734 gagcatcccc tacact 16 <210> 1735 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1735 gctgggcctt tagctg 16 <210> 1736 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1736 ttggtcaatt gggcag 16 <210> 1737 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1737 gtctcatgag gcctat 16 <210> 1738 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1738 ggaggtggga tcccac 16 <210> 1739 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1739 gcccactacc tagcac 16 <210> 1740 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1740 cccagctggc tggtcg 16 <210> 1741 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1741 gcaccaggtc tcctgt 16 <210> 1742 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1742 gtctagaagc ctaggg 16 <210> 1743 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1743 gccgggtgtt ggtgca 16 <210> 1744 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1744 ttggtgcctg tgttgc 16 <210> 1745 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1745 tgcttctgat ccctac 16 <210> 1746 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1746 gttcccagga ggctta 16 <210> 1747 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1747 aggcccctag agtcta 16 <210> 1748 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1748 tggtgtgccc agactt 16 <210> 1749 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1749 gatggctaac ccactg 16 <210> 1750 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1750 cccccaaaag ttgccc 16 <210> 1751 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1751 tagggtgttc cagatc 16 <210> 1752 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1752 gtaccatgaa gctctg 16 <210> 1753 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1753 cttggacttg gaccat 16 <210> 1754 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1754 gtgcataggg cctgtc 16 <210> 1755 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1755 cctcacctga acaccc 16 <210> 1756 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1756 atgcctcccc gcaact 16 <210> 1757 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1757 ttgtgcttgg gtgtac 16 <210> 1758 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1758 aggcttcatg tgaggt 16 <210> 1759 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1759 tgtaaaaggt cctccc 16 <210> 1760 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1760 gacctgtgca gcaggt 16 <210> 1761 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1761 tcctcttgga gatcca 16 <210> 1762 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1762 aggtcatagg actgct 16 <210> 1763 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1763 gaaggtcaga ctaggg 16 <210> 1764 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1764 tctgtagact gcccag 16 <210> 1765 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1765 gtccctctat tcccct 16 <210> 1766 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1766 aattgccatg ctccca 16 <210> 1767 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1767 gatgaccttc ctccaa 16 <210> 1768 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1768 gtttccagta gcacct 16 <210> 1769 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1769 ggccttgagc tgatgg 16 <210> 1770 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1770 tatccctaat caggct 16 <210> 1771 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1771 ggtgtccaca tcccgg 16 <210> 1772 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1772 agctggacag gccata 16 <210> 1773 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1773 ggtaatcacc cagaga 16 <210> 1774 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1774 gcgctaagtc tgctgt 16 <210> 1775 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1775 cctcaaatct tgccca 16 <210> 1776 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1776 atccagacct ggcaga 16 <210> 1777 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1777 atccctgctc aagtgc 16 <210> 1778 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1778 caggcactcc ttggaa 16 <210> 1779 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1779 agctgaggta tccctc 16 <210> 1780 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1780 gggcccagca agtctt 16 <210> 1781 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1781 gttttgtcag tgtgca 16 <210> 1782 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1782 gtgacctgct gaactc 16 <210> 1783 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1783 ggctgaactg tgcacc 16 <210> 1784 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1784 gggtggtccc actcct 16 <210> 1785 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1785 gaggaatcct gggccc 16 <210> 1786 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1786 atgacaagct aggtgc 16 <210> 1787 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1787 ttgccagaca gggcac 16 <210> 1788 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1788 agacccctcc cactat 16 <210> 1789 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1789 ggtgctgggt gaccgg 16 <210> 1790 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1790 ggccaaacgg tgccct 16 <210> 1791 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1791 tgggtgaata gcaacc 16 <210> 1792 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1792 gcccccaagg aagtga 16 <210> 1793 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1793 caggcttcat gtgtgg 16 <210> 1794 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1794 ctgtcagtgc tttggt 16 <210> 1795 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1795 gagtaccctg gcaggt 16 <210> 1796 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1796 tagctagcac ctgggt 16 <210> 1797 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1797 ggcaaacctt tgagcc 16 <210> 1798 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1798 gctatcattg gagcag 16 <210> 1799 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1799 cctctgagta ctccct 16 <210> 1800 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1800 agctgaaggc aaccag 16 <210> 1801 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1801 gggcagtttt ccatag 16 <210> 1802 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1802 ggtcctacct ctgaca 16 <210> 1803 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1803 ggctgcctta gggtgg 16 <210> 1804 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1804 cgcacctccc ccacta 16 <210> 1805 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1805 gcttattggt ccatgg 16 <210> 1806 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1806 aaccgcagag ccccca 16 <210> 1807 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1807 gggcttgttc tgccaa 16 <210> 1808 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1808 gggacctgcg ctgact 16 <210> 1809 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1809 ctttcacctg gtgact 16 <210> 1810 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1810 agcttgaggg agtata 16 <210> 1811 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1811 gcctgctcaa ttgagg 16 <210> 1812 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1812 atagcagctg gctgcc 16 <210> 1813 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1813 aaaagcttgg cacccc 16 <210> 1814 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1814 cctggcaaga agggcc 16 <210> 1815 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1815 ttagcccatc tatccc 16 <210> 1816 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1816 gtggtctccc tgtgcc 16 <210> 1817 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1817 agccctctct ggcaaa 16 <210> 1818 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1818 ttactgtggc ccgagt 16 <210> 1819 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1819 gtagactcct agggtc 16 <210> 1820 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1820 cctccagtta gtgtgc 16 <210> 1821 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1821 gtgggtggcc aacagg 16 <210> 1822 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1822 gggattccct ggtagc 16 <210> 1823 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1823 gtgagaccgg cctttg 16 <210> 1824 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1824 actggcaccc acttgg 16 <210> 1825 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1825 attggcctaa tgcccc 16 <210> 1826 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1826 aggctataca ttccag 16 <210> 1827 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1827 ggtggcagct aggtgg 16 <210> 1828 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1828 tccacagttg gcactg 16 <210> 1829 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1829 tgggccttag attgta 16 <210> 1830 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1830 tgtcttcctg gtggcc 16 <210> 1831 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1831 cccgcctctc cagcaa 16 <210> 1832 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1832 gcagcagcca ataagt 16 <210> 1833 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1833 ttgtatcctg gcccct 16 <210> 1834 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1834 gcctcatggg ccttac 16 <210> 1835 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1835 ggatgccagt cttggc 16 <210> 1836 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1836 ctgctctcag tacctc 16 <210> 1837 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1837 acccaagaag tcacct 16 <210> 1838 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1838 gcctcaagcc ctaccc 16 <210> 1839 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1839 agctccagcc tataga 16 <210> 1840 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1840 ggtccacatg gcccta 16 <210> 1841 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1841 caggcccagg attgtc 16 <210> 1842 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1842 gggcctgctt tgcagc 16 <210> 1843 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1843 actcctctct ttaggc 16 <210> 1844 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1844 ctgggtaaca gtcctc 16 <210> 1845 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1845 actgtatggt ttccac 16 <210> 1846 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1846 gccaaagata gctctt 16 <210> 1847 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1847 ggcattggaa gttggt 16 <210> 1848 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1848 cccttcctga ccttac 16 <210> 1849 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1849 ttaccctcta ttcacc 16 <210> 1850 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1850 ggcaccccag gccggg 16 <210> 1851 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1851 cagcagctag ttcccc 16 <210> 1852 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1852 gtgggcacta gtgtgt 16 <210> 1853 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1853 tgcccttgtc agggca 16 <210> 1854 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1854 gcagataggc tcagca 16 <210> 1855 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1855 ccctagccct tagcac 16 <210> 1856 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1856 actggaatgg ccctct 16 <210> 1857 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1857 tttgctcatg ctcaca 16 <210> 1858 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1858 gcctttgtgt gtcact 16 <210> 1859 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1859 tatgtggtag catgtc 16 <210> 1860 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1860 ccccaggaag ttggcc 16 <210> 1861 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1861 tagctgtcaa ggccct 16 <210> 1862 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1862 cctagtcagc cactag 16 <210> 1863 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1863 agactcccca tcagcc 16 <210> 1864 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1864 gtgaagggcc ttcatc 16 <210> 1865 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1865 ggttgagagt ccaatg 16 <210> 1866 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1866 cagctaattc cctcat 16 <210> 1867 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1867 ttgtgtctca acccac 16 <210> 1868 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1868 ggctatgctg catgct 16 <210> 1869 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1869 ccccataccc agtgga 16 <210> 1870 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1870 ggtggttttc ctccct 16 <210> 1871 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1871 gagcctgccc aacttt 16 <210> 1872 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1872 tgatgcccaa gagtga 16 <210> 1873 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1873 ttccctctgc gaacat 16 <210> 1874 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1874 gttccatctc aatcca 16 <210> 1875 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1875 acggccactc cactgg 16 <210> 1876 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1876 tggaagtggt tccaga 16 <210> 1877 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1877 ttgccccaga ccaaca 16 <210> 1878 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1878 gaggttgtgg aggtgc 16 <210> 1879 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1879 gagttgctgt gtgtga 16 <210> 1880 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1880 catgtcagag gtgtcc 16 <210> 1881 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1881 aggtaaggat catggc 16 <210> 1882 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1882 gttcagttgc atcacg 16 <210> 1883 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1883 gcccagctag ccaccc 16 <210> 1884 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1884 ccttagcagc caggcc 16 <210> 1885 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1885 gcacttaggg ttttgc 16 <210> 1886 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1886 gttgaacttt ccctac 16 <210> 1887 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1887 tgactccttg agacag 16 <210> 1888 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1888 tgcgctggct tagcaa 16 <210> 1889 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1889 ggcctaacat cagcag 16 <210> 1890 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1890 actcctccca gttagc 16 <210> 1891 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1891 accagtggcc aatgtc 16 <210> 1892 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1892 gcctagacac agtagg 16 <210> 1893 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1893 tattctcccc ctaggg 16 <210> 1894 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1894 gacggccttg ggcaca 16 <210> 1895 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1895 gcaggctgta ttagca 16 <210> 1896 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1896 accccctatc ctgcac 16 <210> 1897 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1897 tcctccatac ctagag 16 <210> 1898 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1898 gataggtgcc cactgt 16 <210> 1899 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1899 gtcagttctg gctagg 16 <210> 1900 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1900 gcctgaactt acaagc 16 <210> 1901 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1901 accctgggct gacctt 16 <210> 1902 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1902 ggacctggac aagcaa 16 <210> 1903 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1903 ctccttgcga gagagg 16 <210> 1904 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1904 agagttgaca tgggca 16 <210> 1905 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1905 cactaggtcc ctgacc 16 <210> 1906 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1906 cactctcttg ggctgt 16 <210> 1907 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1907 agggacctgc attcca 16 <210> 1908 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1908 ttcaccaccc attggg 16 <210> 1909 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1909 atctggtctg agggcc 16 <210> 1910 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1910 gacatgcaat tgaccc 16 <210> 1911 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1911 gtgtgcagca gactgt 16 <210> 1912 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1912 gacagtccag ctgcaa 16 <210> 1913 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1913 cctgcggcag tgaaga 16 <210> 1914 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1914 ctctgaggat aaccct 16 <210> 1915 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1915 gttcccagct ccccaa 16 <210> 1916 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1916 tagggtcagt gtccca 16 <210> 1917 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1917 ggcgagcctc tcagcc 16 <210> 1918 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1918 gactcatcca ggcagt 16 <210> 1919 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1919 tccctccctt aggcac 16 <210> 1920 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1920 gaggagccag gcatat 16 <210> 1921 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1921 caccaacgaa gtcccc 16 <210> 1922 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1922 gctggcagtc accaaa 16 <210> 1923 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1923 gcccacacca ttgagc 16 <210> 1924 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1924 agtgagatgc cctggt 16 <210> 1925 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1925 cactggcagt tagacc 16 <210> 1926 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1926 actctggcca ctagta 16 <210> 1927 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1927 ggtagggtgg ccacat 16 <210> 1928 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1928 gagccatgtc taggca 16 <210> 1929 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1929 cagactgaaa cccacc 16 <210> 1930 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1930 tatggtccag ccacca 16 <210> 1931 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1931 tacctcctct gttggt 16 <210> 1932 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1932 acacctcagt catgat 16 <210> 1933 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1933 aacaggcttc aagagg 16 <210> 1934 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1934 gtactactgg ccatgt 16 <210> 1935 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1935 ctgcaggcgg ttgcta 16 <210> 1936 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1936 gtctgttgcc aagagc 16 <210> 1937 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1937 ccctgggtca cttaag 16 <210> 1938 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1938 cctgtccttg cttgca 16 <210> 1939 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1939 gcccagctta tcctaa 16 <210> 1940 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1940 agtagagcct ttgcct 16 <210> 1941 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1941 ctgtctcttg gcccat 16 <210> 1942 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1942 ggcccaaatc ttgagt 16 <210> 1943 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1943 gcttgttaca gcacta 16 <210> 1944 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1944 actttggccc agagat 16 <210> 1945 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1945 gcagtcaggt cagctg 16 <210> 1946 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1946 gccttgtcct actacc 16 <210> 1947 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1947 ggctctgcta ttggcc 16 <210> 1948 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1948 cttatagagc cttgcc 16 <210> 1949 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1949 ggaagggccc aaatat 16 <210> 1950 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1950 gatctactcc tactgc 16 <210> 1951 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1951 gtcagcctgt gtctga 16 <210> 1952 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1952 agcttcctcc ttacac 16 <210> 1953 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1953 ctgctaagcc cctacc 16 <210> 1954 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1954 agaggtcagg tgcata 16 <210> 1955 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1955 ttcagcctgg ttggga 16 <210> 1956 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1956 gattgattga gctcct 16 <210> 1957 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1957 atggactccc taggct 16 <210> 1958 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1958 tactcaaggg cccctc 16 <210> 1959 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1959 ggcatatgta gcttgc 16 <210> 1960 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1960 gagcttagat ctgtgc 16 <210> 1961 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1961 atgctcacgg ctgtgt 16 <210> 1962 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1962 attgaaaggc ccatca 16 <210> 1963 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1963 caacccagtt tgccgg 16 <210> 1964 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1964 cagctattcc ctgttt 16 <210> 1965 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1965 gctgtgtcac acttcc 16 <210> 1966 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1966 gtccaaggat cacagc 16 <210> 1967 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1967 gctaccacta gagcct 16 <210> 1968 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1968 gtttcagggc ttatgt 16 <210> 1969 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1969 tcccacacct attgaa 16 <210> 1970 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1970 actgactaga gagtcc 16 <210> 1971 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1971 tccaaggctg atgtcc 16 <210> 1972 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1972 tcccatggtg gacatg 16 <210> 1973 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1973 agtagctggc agaagg 16 <210> 1974 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1974 ctgggagtga ctacta 16 <210> 1975 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1975 tggtatagct actggg 16 <210> 1976 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1976 ctgtggtttg gcaggt 16 <210> 1977 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1977 gttctcacct gaacta 16 <210> 1978 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1978 ataggctact ggcagg 16 <210> 1979 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1979 cccagctagc tggagt 16 <210> 1980 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1980 ggctggctct caaagg 16 <210> 1981 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1981 tggtgatact gtggca 16 <210> 1982 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1982 gctgattttg gtgcca 16 <210> 1983 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1983 gctaatcttg cctcga 16 <210> 1984 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1984 cactggtggc tttcaa 16 <210> 1985 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1985 gtccccttct taagca 16 <210> 1986 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1986 gccaggccaa ctgtgg 16 <210> 1987 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1987 ggcccgttat ggtgga 16 <210> 1988 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1988 cctaaagtcc aactcc 16 <210> 1989 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1989 ccctatccag ccttca 16 <210> 1990 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1990 aagcatggcc tctggc 16 <210> 1991 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1991 taccctgcac cctcct 16 <210> 1992 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1992 tccttagtag aatgcc 16 <210> 1993 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1993 ttagccctgg gagcac 16 <210> 1994 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1994 gctgggtcag gtagcg 16 <210> 1995 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1995 gggaggctct caatct 16 <210> 1996 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1996 gtaagtgcag aatgcc 16 <210> 1997 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1997 tgccgaggca ggcacc 16 <210> 1998 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1998 tccgtgtcta ggaggt 16 <210> 1999 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 1999 gtctccctgc attgga 16 <210> 2000 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2000 ccatatcact ctcctc 16 <210> 2001 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2001 cgaacacctt gagcca 16 <210> 2002 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2002 ggcccagctt aagagg 16 <210> 2003 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2003 ctgatactcc taatcc 16 <210> 2004 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2004 gcctgtaggg ctgtgc 16 <210> 2005 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2005 tgccctttct ccctac 16 <210> 2006 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2006 agtgcatgtc agtacc 16 <210> 2007 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2007 tgctcctcag ctgttg 16 <210> 2008 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2008 gtttgggacc atccct 16 <210> 2009 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2009 agtgctctct agggtc 16 <210> 2010 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2010 tacagagaat cacccc 16 <210> 2011 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2011 gtccaagtaa ggtgct 16 <210> 2012 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2012 gaccttgcag gcttcc 16 <210> 2013 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2013 gggcaaagga tcctct 16 <210> 2014 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2014 cccattctgc tatccc 16 <210> 2015 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2015 gctgactagg agggct 16 <210> 2016 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2016 cctgtgaggt agtacc 16 <210> 2017 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2017 gtccccctcc agtcta 16 <210> 2018 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2018 gaggactcaa ttcctc 16 <210> 2019 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2019 gacaaggtcc ttttgg 16 <210> 2020 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2020 gctcttgtgt gcaccc 16 <210> 2021 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2021 tcaccgcctg caccac 16 <210> 2022 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2022 ggttgcactg tgcaat 16 <210> 2023 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2023 ttccacaggc ctccat 16 <210> 2024 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2024 gctgagttcc atatgc 16 <210> 2025 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2025 gaaccgccac ctcagg 16 <210> 2026 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2026 gctcacggtt ggagac 16 <210> 2027 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2027 tgggctccca tgttca 16 <210> 2028 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2028 tcactctacc aacctc 16 <210> 2029 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2029 tccttgctta cagatg 16 <210> 2030 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2030 tgatgctagc attacc 16 <210> 2031 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2031 tgggtaactg gctagt 16 <210> 2032 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2032 aaccattcct caccaa 16 <210> 2033 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2033 gccctgaaca gttgat 16 <210> 2034 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2034 ggctcctatc atacct 16 <210> 2035 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2035 taggtctcac aaccct 16 <210> 2036 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2036 gtgcattagt cttcca 16 <210> 2037 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2037 caaaagccag gttagc 16 <210> 2038 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2038 ctgctgttga ctacct 16 <210> 2039 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2039 gtacctgcca gctact 16 <210> 2040 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2040 cctacctttg ctgttt 16 <210> 2041 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2041 agtcaccagc ctaagc 16 <210> 2042 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2042 aggcaacctg ggagtg 16 <210> 2043 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2043 tggccttcac aatggc 16 <210> 2044 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2044 ggtgaagtgg gttgga 16 <210> 2045 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2045 gctggttgtc tgctgc 16 <210> 2046 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2046 agtttgtgac ccctgc 16 <210> 2047 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2047 ccactcagtg tgaatg 16 <210> 2048 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2048 ctggcctcag ggcaat 16 <210> 2049 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2049 gtagacttgg gtaggt 16 <210> 2050 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2050 tggtgctaag ctctcc 16 <210> 2051 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2051 catgctcaag ctggaa 16 <210> 2052 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2052 aaggtcaaca gcagct 16 <210> 2053 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2053 caaggtcaac agcagc 16 <210> 2054 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2054 ccaaggtcaa cagcag 16 <210> 2055 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2055 gccaaggtca acagca 16 <210> 2056 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2056 tctcacacgc acttca 16 <210> 2057 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2057 atctcacacg cacttc 16 <210> 2058 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2058 gatctcacac gcactt 16 <210> 2059 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2059 ctttcatgaa tcaagc 16 <210> 2060 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2060 tctttcatga atcaag 16 <210> 2061 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2061 gtctttcatg aatcaa 16 <210> 2062 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2062 ggtctttcat gaatca 16 <210> 2063 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2063 atggtctttc atgaat 16 <210> 2064 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2064 gatggtcttt catgaa 16 <210> 2065 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2065 tgatggtctt tcatga 16 <210> 2066 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2066 tatatcaata ttctcc 16 <210> 2067 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2067 ttatatcaat attctc 16 <210> 2068 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2068 gttatatcaa tattct 16 <210> 2069 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2069 tttctttagc aatagt 16 <210> 2070 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2070 ctttctttag caatag 16 <210> 2071 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2071 gctttcttta gcaata 16 <210> 2072 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2072 ctccattagg gttctg 16 <210> 2073 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2073 tctccattag ggttct 16 <210> 2074 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2074 ttctccatta gggttc 16 <210> 2075 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2075 gttctccatt agggtt 16 <210> 2076 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2076 aggttggcag acagac 16 <210> 2077 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2077 caggttggca gacaga 16 <210> 2078 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2078 gcaggttggc agacag 16 <210> 2079 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2079 cttcttgtga gctggc 16 <210> 2080 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2080 tcttcttgtg agctgg 16 <210> 2081 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2081 gtcttcttgt gagctg 16 <210> 2082 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2082 agtcttcttg tgagct 16 <210> 2083 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2083 tcttccactc acatcc 16 <210> 2084 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2084 ctcttccact cacatc 16 <210> 2085 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2085 tctcttccac tcacat 16 <210> 2086 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2086 gtctcttcca ctcaca 16 <210> 2087 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2087 atagattttg acttcc 16 <210> 2088 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2088 catagatttt gacttc 16 <210> 2089 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2089 gcatagattt tgactt 16 <210> 2090 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2090 aaatgtcaac agtgca 16 <210> 2091 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2091 catgactatg ttctgg 16 <210> 2092 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2092 acatgactat gttctg 16 <210> 2093 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2093 cacatgacta tgttct 16 <210> 2094 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2094 gaattctgag ctctgg 16 <210> 2095 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2095 tgaattctga gctctg 16 <210> 2096 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2096 ctgaattctg agctct 16 <210> 2097 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2097 cctgaattct gagctc 16 <210> 2098 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2098 gcctgaattc tgagct 16 <210> 2099 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2099 agcctgaatt ctgagc 16 <210> 2100 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2100 atattgtaat tcttgg 16 <210> 2101 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2101 gatattgtaa ttcttg 16 <210> 2102 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2102 tgatattgta attctt 16 <210> 2103 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2103 ctgatattgt aattct 16 <210> 2104 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2104 cctgatattg taattc 16 <210> 2105 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2105 gcctgatatt gtaatt 16 <210> 2106 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2106 tgcctgatat tgtaat 16 <210> 2107 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2107 attatgtgct ttgcct 16 <210> 2108 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2108 aattatgtgc tttgcc 16 <210> 2109 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2109 caattatgtg ctttgc 16 <210> 2110 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2110 tcaattatgt gctttg 16 <210> 2111 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2111 gtcaattatg tgcttt 16 <210> 2112 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2112 gccatcacca aacacc 16 <210> 2113 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2113 tgccatcacc aaacac 16 <210> 2114 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2114 ttgccatcac caaaca 16 <210> 2115 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2115 tggtgactct gcctga 16 <210> 2116 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2116 ctggtgactc tgcctg 16 <210> 2117 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2117 gctggtgact ctgcct 16 <210> 2118 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2118 tgctggtgac tctgcc 16 <210> 2119 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2119 ctgctggtga ctctgc 16 <210> 2120 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2120 agtagtcaat attatt 16 <210> 2121 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2121 cagtagtcaa tattat 16 <210> 2122 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2122 ccagtagtca atatta 16 <210> 2123 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2123 cctttgggtg aatagc 16 <210> 2124 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2124 acctttgggt gaatag 16 <210> 2125 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2125 cacctttggg tgaata 16 <210> 2126 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2126 caacttgagg acaata 16 <210> 2127 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2127 ctcaacttga ggacaa 16 <210> 2128 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2128 caggaagaaa ggaacc 16 <210> 2129 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2129 ccaggaagaa aggaac 16 <210> 2130 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2130 accaggaaga aaggaa 16 <210> 2131 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2131 tgcagtcatg tacaca 16 <210> 2132 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2132 ctgcagtcat gtacac 16 <210> 2133 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2133 tctgcagtca tgtaca 16 <210> 2134 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2134 tggtttgtca atcctt 16 <210> 2135 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2135 cttggtttgt caatcc 16 <210> 2136 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2136 gctacaatgc acagga 16 <210> 2137 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2137 tgctacaatg cacagg 16 <210> 2138 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2138 gatatttatt gctgta 16 <210> 2139 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2139 tgatatttat tgctgt 16 <210> 2140 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2140 ctgatattta ttgctg 16 <210> 2141 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2141 agggtcttta caaagt 16 <210> 2142 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2142 cagggtcttt acaaag 16 <210> 2143 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2143 ccagggtctt tacaaa 16 <210> 2144 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2144 ttctgcagta tcctag 16 <210> 2145 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2145 tttctgcagt atccta 16 <210> 2146 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2146 gtttctgcag tatcct 16 <210> 2147 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2147 agtttctgca gtatcc 16 <210> 2148 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2148 cagtttctgc agtatc 16 <210> 2149 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2149 caaattccag tcctag 16 <210> 2150 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2150 ccaaattcca gtccta 16 <210> 2151 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2151 tccaaattcc agtcct 16 <210> 2152 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2152 acccatttca tccatt 16 <210> 2153 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2153 aacccatttc atccat 16 <210> 2154 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2154 gaacccattt catcca 16 <210> 2155 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2155 ggaacccatt tcatcc 16 <210> 2156 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2156 aggaacccat ttcatc 16 <210> 2157 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2157 gcttcatgtc tttcta 16 <210> 2158 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2158 tgcttcatgt ctttct 16 <210> 2159 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2159 gtgcttcatg tctttc 16 <210> 2160 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2160 tgagcttagc agtcac 16 <210> 2161 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2161 atgagcttag cagtca 16 <210> 2162 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2162 catgagctta gcagtc 16 <210> 2163 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2163 tacagacata gctcta 16 <210> 2164 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2164 atacagacat agctct 16 <210> 2165 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2165 gatacagaca tagctc 16 <210> 2166 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2166 ggatacagac atagct 16 <210> 2167 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2167 tgtggcttta attcac 16 <210> 2168 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2168 atgtggcttt aattca 16 <210> 2169 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2169 tatgtggctt taattc 16 <210> 2170 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2170 tgttcagttg catcac 16 <210> 2171 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2171 gtgttcagtt gcatca 16 <210> 2172 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2172 tgtgttcagt tgcatc 16 <210> 2173 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2173 catctggatg tgaggc 16 <210> 2174 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2174 acatctggat gtgagg 16 <210> 2175 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2175 cacatctgga tgtgag 16 <210> 2176 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2176 tcaggtaatt tctgga 16 <210> 2177 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2177 ctcaggtaat ttctgg 16 <210> 2178 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2178 tctcaggtaa tttctg 16 <210> 2179 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2179 tgcttattta cctggg 16 <210> 2180 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2180 ttgcttattt acctgg 16 <210> 2181 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2181 tttgcttatt tacctg 16 <210> 2182 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2182 ttttgcttat ttacct 16 <210> 2183 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2183 atgatgttac tactac 16 <210> 2184 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2184 aatgatgtta ctacta 16 <210> 2185 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2185 caatgatgtt actact 16 <210> 2186 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2186 cccctagagc aatggt 16 <210> 2187 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2187 ccccctagag caatgg 16 <210> 2188 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2188 tccccctaga gcaatg 16 <210> 2189 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2189 tcaattgcag atgctc 16 <210> 2190 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2190 ctcaattgca gatgct 16 <210> 2191 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2191 gctcaattgc agatgc 16 <210> 2192 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2192 agctcaattg cagatg 16 <210> 2193 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2193 gtatattcag tccaag 16 <210> 2194 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2194 agtatattca gtccaa 16 <210> 2195 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2195 cagtatattc agtcca 16 <210> 2196 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2196 acctccgagc ttcgcc 16 <210> 2197 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2197 gtaggacctc cgagct 16 <210> 2198 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2198 acctgtagga cctccg 16 <210> 2199 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2199 cagtgccaag gtcaac 16 <210> 2200 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2200 acttgatcct gccagt 16 <210> 2201 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2201 ctcgctcagg tgaacg 16 <210> 2202 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2202 agtctctcgc tcaggt 16 <210> 2203 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2203 ccttctggta tagaac 16 <210> 2204 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2204 gctagttagc ttgata 16 <210> 2205 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2205 tctggttgca ctattt 16 <210> 2206 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2206 ggatctggtt gcacta 16 <210> 2207 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2207 ggtggatctg gttgca 16 <210> 2208 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2208 gcaatgggtg gatctg 16 <210> 2209 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2209 cagttgaggg caatgg 16 <210> 2210 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2210 agtccagttg agggca 16 <210> 2211 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2211 gtaaagtcca gttgag 16 <210> 2212 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2212 gttcagtaaa gtccag 16 <210> 2213 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2213 ctgcatgaat cccagt 16 <210> 2214 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2214 acatagagca cctcac 16 <210> 2215 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2215 gttacataga gcacct 16 <210> 2216 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2216 agtgttacat agagca 16 <210> 2217 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2217 tccttgagga gatctg 16 <210> 2218 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2218 gctatcatga atggct 16 <210> 2219 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2219 cgggtttata gctatc 16 <210> 2220 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2220 atccttcacc cctagg 16 <210> 2221 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2221 gagtcgccat ccttca 16 <210> 2222 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2222 tccagagtcg ccatcc 16 <210> 2223 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2223 ggctgagcaa cctctg 16 <210> 2224 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2224 ctgtggctga gcaacc 16 <210> 2225 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2225 gataacactg ggctgc 16 <210> 2226 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2226 tgcttggata acactg 16 <210> 2227 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2227 ctctgcttgg ataaca 16 <210> 2228 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2228 gctgaatatg ggcagc 16 <210> 2229 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2229 cttggattgc ttagct 16 <210> 2230 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2230 cctgggcata aaagtc 16 <210> 2231 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2231 accttgatgt gaggag 16 <210> 2232 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2232 gattcaacct tgatgt 16 <210> 2233 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2233 atgtgtgatt caacct 16 <210> 2234 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2234 tgggacaggc atctca 16 <210> 2235 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2235 tagtctggga caggca 16 <210> 2236 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2236 ggaggtatag tctggg 16 <210> 2237 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2237 ggactgtact atatga 16 <210> 2238 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2238 tcagttggtc tgtgct 16 <210> 2239 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2239 gctaaggcat gatttt 16 <210> 2240 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2240 gccatgcttg aagtct 16 <210> 2241 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2241 atagccatgc ttgaag 16 <210> 2242 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2242 acacagtgtg tagtgt 16 <210> 2243 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2243 ctgcagtaca cagtgt 16 <210> 2244 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2244 accaactgca gtacac 16 <210> 2245 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2245 tagactgtag ttgcta 16 <210> 2246 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2246 accagcttta gactgt 16 <210> 2247 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2247 gtaagttgat ctgtgc 16 <210> 2248 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2248 tacttctttt ggtgcc 16 <210> 2249 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2249 tcttgtacct tattcc 16 <210> 2250 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2250 tggttatagg ctgtga 16 <210> 2251 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2251 gtctggttat aggctg 16 <210> 2252 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2252 atgtgtctgg ttatag 16 <210> 2253 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2253 gagtatgtgt ctggtt 16 <210> 2254 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2254 ggtctgcgat aaatgg 16 <210> 2255 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2255 gccagacaca actagt 16 <210> 2256 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2256 accgccactg tagcag 16 <210> 2257 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2257 ccgccaccgc cactgt 16 <210> 2258 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2258 gggcctccgg cccgcg 16 <210> 2259 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2259 agagcgcggg ttcgcg 16 <210> 2260 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2260 tactgacccc agttcc 16 <210> 2261 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2261 actctactga ccccag 16 <210> 2262 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2262 gtcactctac tgaccc 16 <210> 2263 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2263 ttcatgcgga ctggtg 16 <210> 2264 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2264 gtgagcatgg acccca 16 <210> 2265 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2265 tgatatgtga gcatgg 16 <210> 2266 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2266 aagttggtga gcttct 16 <210> 2267 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2267 ccttcaagtt ggtgag 16 <210> 2268 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2268 gtaagatcct tttgcc 16 <210> 2269 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2269 cagctgtgca acttgc 16 <210> 2270 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2270 gccttggtag gtaggg 16 <210> 2271 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2271 agagccttgg taggta 16 <210> 2272 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2272 cccgcacaaa cgcgca 16 <210> 2273 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2273 gtcttcaagg tcagtt 16 <210> 2274 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2274 gcccagtgaa ttcagc 16 <210> 2275 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2275 agatgcgccc agtgaa 16 <210> 2276 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2276 gtaagatgcg cccagt 16 <210> 2277 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2277 ccagaaggca cttgta 16 <210> 2278 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2278 ggaagatttg cagaac 16 <210> 2279 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2279 ccttggtcat ggaaga 16 <210> 2280 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2280 tgaccttggt catgga 16 <210> 2281 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2281 gaggtgacct tggtca 16 <210> 2282 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2282 atccaaagag gtgacc 16 <210> 2283 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2283 gccaatccaa agaggt 16 <210> 2284 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2284 ggtctgccaa tccaaa 16 <210> 2285 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2285 ccctgggtct gccaat 16 <210> 2286 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2286 gagatctcaa caaggg 16 <210> 2287 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2287 cgcccatcac tcttcc 16 <210> 2288 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2288 cacctgtcgc ccatca 16 <210> 2289 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2289 catcacctgt cgccca 16 <210> 2290 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2290 caccatcacc tgtcgc 16 <210> 2291 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2291 aatagttgtc accatc 16 <210> 2292 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2292 gccacctttc atgaga 16 <210> 2293 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2293 ctcttggaag taggta 16 <210> 2294 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2294 gttctcttgg aagtag 16 <210> 2295 <211> 16 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2295 taaacaggtt ggtctg 16 <210> 2296 <211> 310001 <212> DNA <213> Macaca mulatta <220> <221> misc_feature <222> (17323)..(17436) <223> n is a, c, g, or t <220> <221> misc_feature <222> (25984)..(26003) <223> n is a, c, g, or t <220> <221> misc_feature <222> (107240)..(107259) <223> n is a, c, g, or t <220> <221> misc_feature <222> (113595)..(113619) <223> n is a, c, g, or t <220> <221> misc_feature <222> (136036)..(136328) <223> n is a, c, g, or t <220> <221> misc_feature <222> (140788)..(140807) <223> n is a, c, g, or t <220> <221> misc_feature <222> (192868)..(193398) <223> n is a, c, g, or t <220> <221> misc_feature <222> (210347)..(210366) <223> n is a, c, g, or t <220> <221> misc_feature <222> (218041)..(218671) <223> n is a, c, g, or t <220> <221> misc_feature <222> (243838)..(243998) <223> n is a, c, g, or t <220> <221> misc_feature <222> (291980)..(292210) <223> n is a, c, g, or t <220> <221> misc_feature <222> (293097)..(293542) <223> n is a, c, g, or t <400> 2296 tgtgattggc gtatgtttaa ggagaaagaa ccagagttca gatgtggaca tgtcaagttt 60 cagaggtctg ttagacatcc aaatggagat atccagttgc tagcctggag ctctgtggag 120 agatctgggt ttgagttata aatccaagag atagaagttt tcaatcaatt tgattattta 180 ttgggcactc tatataaacc ctacaaatac tgggcactaa cctagacatt acaggtacag 240 atattaagaa tatatagttt ctccctcaga aatctcttaa ttaatgagaa aagcagacat 300 ataacaaaaa ctgcaatatt taataaaaga agatataaag gcctataaag gtgctgatac 360 acagagaatt aactaataaa ttccaccctg gggaatagtc aggaagagct tcagagagaa 420 ggtaaataat tgattggaac tttaaggcaa agaaggattt ctctgggtgg acaaagtagg 480 atcttccaag tagagtggaa accataagca aatgcagttt cactcttcaa aaggtaaatg 540 tgctctggaa tgccttaact tgtaacaaat taatcaactc aatacctgct acattttccc 600 tcacaatttg gaatatataa agaggcacat actaccatag accaatacct ggtcataaat 660 gagattgagg gacctttatt catgaagctt aaaaataaag gctgcccttc atgtcagttg 720 caggtttata tctagctcta taatattaac tgaggtgtct ttttctatgt tttctgtgca 780 tgatgagttt ttaaaaatca aagacagagc agcaggcaga gtagtctagt ttcatggcac 840 acagaatgga ggatattgct gaacccagat ttttaaaaaa ggaagtcagt tcttcttttt 900 ttaagtatgg ccctgagctc atctcagagc ataaacaata gaatttagaa taccttttat 960 gatgccgtct ggcacctcct atactagatc aagattctct agctcaggga agaagggcaa 1020 aggatgagaa ggcacagaga ggatataaac agagattggt agtgccaagc tctgaagaag 1080 gtccaacttg gaaggtcatt tcagacagga gtggagtcag catttgagga ctgtctggtc 1140 tctactcctg ccaggactgc actgtcagcc agcttggcat gtatggacca ccgagcagga 1200 gtttttcttg actgtgccct aatcttttac tttcccaagt ttctctatat gggtacttcc 1260 ccttttaaaa gctccagaca cagccaagca cccctattgc tctagcaaag tatgaaaccc 1320 cagaaatcaa tggtttgggg aagagtctta ggggaaataa aagcttcctt attcttagat 1380 gggatagaac aagagcagtt caggatcaat aaccatccca ccccatgata aaacatgccc 1440 cttccagaac ctttcctttt ttgttcattc taggtgtcta tctggaacag ctggggtatt 1500 tgagccacag ctaagcttct gaaagtattc taaggaatag tttttcactt acttgattcc 1560 tttgaaaata ggggtatctt atgtgataac tgctatccca gagtctttga tcctctgttc 1620 gttctcaagt cttggctacc gtgtactact tcaaagctct gtagatattt tattctaaag 1680 aaaagaaact tggttccttt aagttgttgt tgaaacattt ctctctgggt ataaacttgg 1740 gttgtatctg ggagctctgt ttaaaaaaaa aaaaaaatgt ctttagtaag ccaaagctgt 1800 tagaagctta taagtaagtg acattacaat tgatggtcag taaatagtgg aaagatcgca 1860 tgactaactt ctccttcaga tctgagacaa cctggagcta gacttttgta ctctctgctc 1920 agaaaagcac atagtggctc ggggtttgat gtagtacaaa aatgacatgc ttatgtacaa 1980 ctttaacttt ctgcagcact ttttacaact tcttgtgaat gaagtaggca gggcttgcat 2040 ttgacagatg aactatgtcc agcgtgaggc agagttaaaa ccctttcctt ggctcaggaa 2100 cttcaggctg gggcctgtgt ctgctctccc tatatccctg tcctctagca gatacctctc 2160 tgctaacatg ctgagtgtcc tcggtaaatt actcaatctc tctgtctccg tcttctaacc 2220 tccacaataa agcccctcgt agttttaact atctttttca ctgcgcccca gtgagcagga 2280 gtttggaact taattgctga tggaaaggca atatttggat ggctaaacac gctttccaag 2340 ctatcttgct gattttcctc tcattcctgg agataactca tctttttgta agtgtttctt 2400 tgagtctgtg gattgctctt aacgctcttg taggtcctgc cttcatttgg gaacaggggc 2460 aggcggaaag aaaaggaagt gtattgcaac taccaatatc ttcctctagg aggagctgcg 2520 cagcccagat gagagtgaca cgcaccaact ccagctcctc gccgggaaga cttcatccca 2580 gcaactcgga acgcttggcc ggggcggcac tcggtctctc cgcagcagtt ctcgaactgg 2640 cctccttgaa cgtcggtttc cccttcgctt ctgcagcctg gatctggggg acggcgggcc 2700 aggcccggcg tgaccgctgg tgaacggtgg ccgccttttc ccacccctgc tctcccatcc 2760 tcccttcccg ttttaccccg ccccctctct cctccccaag cctgacagcc cacgagctgc 2820 caagcagggc gcagccatgg gaagaggagg agggctaggg agcggcggcg gcggcggcgg 2880 cagcggcagc ggcggctgct acagtggcgg tggcggcggc ggctgctgct gagcccgggc 2940 ggcggcgggg accccgggct gaggccacgc gggccggagg ccccagcacc attggcccca 3000 gcgcagacgc gaacccgcgc tctctctcca gaggcgaagc tcggaggtac tggagtgggg 3060 ctccgggagt ctggctttat tttcctcctg ttgtgccagg gggcctgaga gtgaaccctg 3120 ggactctagt tgtttatgaa aatgggagga tctgtcttat atatttacat ggatgatttt 3180 ttatttcgga tgacttggct gtgctcccct cctccttgcg aagaagttgt tttctgctgg 3240 tgggttgttg taacccaatc gagtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt 3300 gtgtgtgtct ggaagttggt ggaggcggca gggagttgcg ggcgacagac gaaccatccc 3360 actctggcgt ctgctgtggc ccgcgagtag ggtgcgtgga ggggtttact ccggagatag 3420 ttttgttaaa gtcataaaag ttttgctagt gtgtttctgt ttgccatcat ctgcctggct 3480 gaggcagagc tgccgaggct gctgctgctg cgcggggaag gatctccggc agcgagactg 3540 gagagattgg gaaggtcgag ctgtgcgcgt gaacacggcg cgcagagcgc gcagtctttt 3600 gcgcgtttgt gcgggctgca gccgcacatt ggcaccggtg gaactggggt cagtagagtg 3660 acggccacca gtccgcatga attggcgtaa gtggaaattg tggcgagccg tcctccccga 3720 gcctccccga gccgtcctcc ccgagcctct acaactagtg gttgtaaaat caaccaggct 3780 taaagttttg acagaactgc cagaggtgcg ggtcaatggg gtggccgcgt gtctagggag 3840 agggcgctgg cggcacagag ggtgcgggtc agggtcaccc acttgcgagt gcgtggggaa 3900 gtctatttgg ggcgaatgct ttacatatag ccggaggaga tgcctgctga gaccgagctg 3960 cgggggttct cggtctggcg tggactgtgt gtcctgaatg agtgtaagtg tgcgctgttt 4020 gcgcgcgcgc gagtgtgcgc ctggggaggc gtgtcggcgc ctgagccagt cgggtgtgca 4080 gggtggaaga ggccacagag gtgccgcctg cctgtttgtg cagccaggag accttggaag 4140 ggacagagaa aggtaacggg aggccaaagt gttgggaagt cagagtagtt tctgcatagg 4200 attaagtatt aagggcttta aaataactaa acccattgcc ctgagtgact gaggactgga 4260 agtgagcgtt tggggagttc tcaggagaac tgcatgggag ggcgtttggg aggtctaaga 4320 gatgtgtaat atgtgtgagt acagaacttc ggagacagac acaggttgga gctatgaatt 4380 tgagattttc agggtgctgc tgtccacagt ccagggactg gctggtttca gaggtgttca 4440 ggctccctgg tgtgtgtgcc tgggaagaca ctcatctttt ctcccagaca tgggatattg 4500 tggcagctca ggttctgttt cctgagcaac tggtgttcca ggctggtttc cacctgaatc 4560 accctagaag tatctttttt ctgatgataa atgttgaaac atttccagaa attaaaatgc 4620 tggatagaaa caaaattgat gcagcagata ggattgttag tgattgggag ctctttttcc 4680 ctttgagaaa agcaaagctt cgtgttccca gattagattt caaggagtct tcagttattt 4740 acagcttccc ttcagatggg cctttggatg gagctggaag gatgtgtttt ggcctagaga 4800 cctttggaag acatcatgtg tagcttaaag gggttgtccc atctgtcatc atcttcttcc 4860 acccttgtaa acttttgttt tgcattaatc taaggaaagt tggtgagtca acatttagct 4920 ttttgttgtt gttgttgttg gagtaaatat atcacagtga aattatagtt gtggtctcct 4980 gaaggccatg caaaccaaca cttaatgggc aaaggtgtga aatgaaagtc tataaatgca 5040 atgacaaagt gacgagatga atgcattctt ttttcaaaat gaacataact gtgctcacaa 5100 aaatttattc tagccaggat tgggcccatg ttttttatca ttagttttta aacagcagac 5160 tccacatcat aaaccacttt aaaatggata ctagaggcct atgctatctc tggcgcctgc 5220 ttaaacagat gtttacagtg cttggtaacc tatgggattg tcatgttgag tatcttgtta 5280 gctcaggaca taatgtttat agcataatat aataaatgga gccacagttg cagcatgctt 5340 cttccaagtg catgaagcaa atcttgcatc agggaaacaa attctgcagt tggtccaact 5400 tggctagcct tctttgggta tctcctggta agcactgtta atgtaaagat aaatgtgagt 5460 aacacggtga gaaagtagga cagtaaattg tttagcttag tgaaaaaaag catggattat 5520 gctttttaaa tctgctaacc tgaagattac acttctcagg ttataccact ggtaaattgc 5580 acaactatga gaatttggtt tgcttttaaa gaacaatttt taagaagtat gtcaataatg 5640 aaaataacat atttcttaat gtgtttacat gtgtccatac aagccaatac tttttcttct 5700 ttaaaaagaa ccctataatt tctgtggtaa tgatttaaat gttatgagca ttcaaatcac 5760 ctaatcacct tttcaatctt caattgataa gaatcgaagt ctggtaagac tggagtcatc 5820 cctcagccaa ttgtgtaaac aagacagtac agaatgtctt tctggcaagt aatttttttc 5880 aacctgaaac agataatata aataatatgt cccataaaag aattacttag gatgataatt 5940 actttagagg taattatctg gtgcatgaac ctccatctgt gaaaatggtc taatctatct 6000 cttcttggaa ataatcagtt ggaaatctcc ctttttcatt gttcagtcca ttctaggaaa 6060 gattgatttc tagaaagttc tgccttatac tgaatcaaca ttttcttcca tccacttgcc 6120 tgtccttcag gagctgacca caatgaatct agtctctttt ccctgtgttt accatacttg 6180 aaaacaaaca ttatgctcct tgctgaatcc ccttttgcct acttttgtag cagtttttca 6240 cccactgtag ggttccaccc tcctctgcct tgaaccatat gcccttgatt ctacattctc 6300 attgtattag tctgttctca tgctgctaat aaagacatac gtgagactgt gtaatttata 6360 aagaaaaaga ggtttaatgg actcacagtt ccacatggct ggggaggcct cacaatcatt 6420 tccgaaggtg aaggaggagc aaaggcatgt cttacatgac agcaggcaag aaagcaagtg 6480 ctttctataa agggaactgc cctttataga accatcagat ctcattagac ttattcacta 6540 tcatgagaac aacatgggaa aaacccactt ccatgattta attaactcct actgggtccc 6600 ttccaccaca tatgggaatt atgggaacta cagttgaaga tgacatttgg gtgaagacaa 6660 agccaaacca tatcgttcca ctcctacccc ctcctaaatc tcatgttttc tcatttcaaa 6720 agcaatcatg ctttcccaac agtcccccaa agtcttaact catttcagca ttagctcaaa 6780 aatccacagt ccaaagtctc acctgaacca aggcaagtct cttccaccta tgagccagta 6840 aaatcaaaag caagttagtt actttctaaa tacaatggag gtacaggcat tgtgtaaata 6900 tgcctattcc aaatgggaga aattggccca aacagagggg ctataggtgc aagtccaaag 6960 tctaataggg cagtcatcaa accttaaagt tccgaaatga tctcctttga cttcatgtct 7020 cacatccagg tcacactgat gcaaaatgtg ggctcccatg accttgcaca gctccgcctc 7080 tgtggctttg caggatacaa cttctctcct ggctgttttc atagctggcg ttgatggtgg 7140 cttttccagg cacatggtgc tagctgttag tggatctacc attctgaggg ctgggggatg 7200 gtggccctct tctcatagct ctactaggca gtaacccagt ggggactctg tgtagaggat 7260 ccaactccac atttcttttc cacattgccc tagcaggggt tctttatgag ggctctgccc 7320 ctgcagcaca actctgcctg gacatccagg catttcctta catcctctga aatctaggtg 7380 gaagttccca aacctcaatt cttgtcttct gtgcacctgc aggaccaaca ccacgtggaa 7440 gctgccaaat cttcaggctt tcaccctctt cagtcgtggc ctgagctgta ccttggcccc 7500 ttttagacat ggctggaggg gctgggacac agggcaccaa gtccctaggc tgcacctaac 7560 aggcccagaa aaccatgttt cctctaggcc tccggacctg tgatgggagg ggctgccata 7620 aagacctctg acatgttctg gagacatttt ccctattgtg ttggtgacca acatttggct 7680 tctcattact tatgtaaatt tctgcagcag tcttgaattt ctccccagaa aatgggtttt 7740 tctttcctat ggcatcatca gcctgcaaat tttccaaact tttatgctct tttcacctcg 7800 tgaatgcttt gctgcttaga aatttcttct gccagatacc ctaattaatc tctctcaagt 7860 ttaaagttcc acagatctct agggcggggg caaaatgcct ccagtctctt tgctaaagca 7920 ttaacaagag tcacctttgc tccagttccc aacaagttcc tcaccttgat ctgagaccac 7980 atcagcctag actttattgt ccatatcact ataagcattt tggtcaaagc cattcaacaa 8040 atctctagga agttccaaac tttcccacat cttcctgttt tctgagccat tcaagtctct 8100 agaaagttcc aaactttccc acattttcct gtcttctttt gagctctcca aactgttcaa 8160 acctctgcct gtaacccagt tctaaagttg cttccacatt ttggggtatc tttacagcag 8220 cacccagtct accattacca atttactgta ttagccgatt ctcatgcttc taataaagac 8280 atacccaaga ctgggtaatt tataaagaaa attaggttta atggactcac agttccacgt 8340 ggctgggagg cctctcaatc atggcagaag gtgaacgagg aataacgcac tctcacgtgg 8400 cggcagacaa taaagcatgt gccagggaac tgccctttat aaaaccatca gatctcatga 8460 gacttaatca ctatggcaag aacagcatgg gaaaaactcg ccctcatgat tcaattacct 8520 cccactgggt tcctcccatg acatatgggg attatgggag ctaaaattca agatgagatt 8580 ggggtgggga cacagcaaaa ccatatcact gaccatccct cctaatgtgt gttttctaaa 8640 ccgaagattt agaattcgta gttctgaaca ttctatatct attaagacag tttaatatta 8700 atgaaattct ttagccattt cattacactc ttgattaatt tcatacctat aaacaaaata 8760 acttgttctt ttcagattat taatcatcca tagtcaaagc atttttataa tagcttcaaa 8820 acattttttc atgcctgaag gtactataaa tttatggaaa gtataatact gtgtgggtaa 8880 ataaaattct atatgcagtg caaatagagc cttaatttct ccctatcagg gaatatcaac 8940 cccaaaatac cggaagtaga atgttccaaa gataaacaag ttgaagctac atgttataga 9000 caggtaggga ctatgatgtg tttttttcat aggcctcatt gtgtctgctt ccatgaacat 9060 gaatcagtac tagcaatcag gcatgtattg aagacttgtt ctgccgaagt cccagagagt 9120 atgccatctg gccttaaatg aagtgaaagt acatcaaata aagatacttc cttgggcaac 9180 tgggatttaa gatgtatatg caggacatga ctaagtcaac catctacttt ttctcaggaa 9240 gtaaatggct tgccaatgcc acaggaaagt ctaaagcgtt cacactccat aagcgtgtcc 9300 catgtcctgt tgtgtgtctg gacaggagct ggacaaaggc cctgttacta cttctagctt 9360 accaagtctt agctgccttg gaggaagaca gcgaatctgg cttatccaga ggagaggcct 9420 gaactgtgaa tggggtacct acctggtgtg actgatttct cttttatgta tctgtcttgg 9480 gcttccagct aaattgtgaa ttcaccttgc attgtcttcc tacacacaca cacaaacatt 9540 tatggtggat gttgaagaca atgtcagttt ttcagcaagt ctgaatgtga aacaaatgac 9600 tatgtttctt ggtgcagtgg ggtgtgagga tgagagacag gaaaccaacc tgtgatataa 9660 actgacatct gagcctacca aaagcccttt gagagacctt tgatcaagac aaagggataa 9720 tcatagcctt gtgcacttag atgaaattgt ccatgctatt cctgtatgtg tgtgtgtgcg 9780 tgtgtgtgta tgtgtgtgtt tcttcacttt atccccagca ttatggtctc aattcatata 9840 catttgcttt tttctttatt ctattctgat ataaaggaaa gaaataatca atgattcatt 9900 tccttttttt aacatttcaa aaatttattt cattattccc tacctcccag tcctcacccc 9960 ccaaaattac aattacgata gacccattgg caagtacttg gacatgcaat tttcaaacca 10020 aaggtttact ttgctataag aaacatctaa gttaggatgt tataatatga aataatagca 10080 aattagatgt caagaaacct gggtcctctc caagctctgc ctttaatggg ctttgcattt 10140 ttttgcaaac tatttaacct tcctgggctt catatttctt atatgttaaa aacaaacaag 10200 caaaaaggag gagtaaacaa aatgacccct tagaattctc ttcagggtta tggtttgaat 10260 gcatttaatt atcgaatttc tctcttcttt taaatgtaag catcaagaaa atatttgcct 10320 attttattct ctcatcatta atttttaatc aattaaataa agtagatgaa aattttatca 10380 aaaccatgtt tcttgctttc attctaaaac aatgcaactc accactatct gattcagaaa 10440 gtctttctga aatagtgttt ttttcttttg ttgttgtttt ttctttgtgc taaagaaaat 10500 tcattgatga gtaccaagtt cttaaaagaa ggatggaaaa gtcattgttg tttagtctca 10560 acttctttct tcagtgcttc ctcctacctc ttaaataggc aaataaagcc ttaggccagg 10620 cactaatttt gcttagtaat gattcataag aaggtagtga ttttgtcaga aattgctggg 10680 ctgcatgctt ttaatcagcg tctaaactta ccttgaaata ctccattcca aaatcagcag 10740 ataatttctt ctagagagtc tttcaaactc tagtgtcaaa cagatgtgtt tactgttttg 10800 attagggctt atttcttttg ttgttgataa gacttcagcc agttttcttt agactaatat 10860 tattatattc ccaatgaatt atactcttag gttgtgaatt tgtttaaaga taaatctatc 10920 tccagctggc tggcttccaa gtaaaaaggg tatcctaggg aagaagtgca cttcacaggg 10980 attcagtaca ggtgtagaga attccctgat agagaattgg aacacatcaa gagtttgcaa 11040 attgaaaagg tacttttatg tgcttatcca tggtggacaa cccgtgtcct agggaagaag 11100 cgcatttcac agggattcag cacaggtgta gagaattccc tgatagggaa ctggaacaca 11160 tcacgatttt gcaaactgag caagtacttt tatgtactta tccatggttg acaacctact 11220 gtgctagaca tttgctgtag taactccttg attttttcct cagttgttta taaaattaaa 11280 cagttgaagt agcctattga aaactcttaa aagaggcctc tcttatattc ctttagaata 11340 cagtatatta aacaagtgat aaagtccaaa gaaaaatcct tattcttttc ttgctttaaa 11400 aaatgcactt tattgtatta agcattatat ctatctttta aaactttgaa ttgccatatc 11460 aatgaaagta gagtgttatc attacaaaac agaatcgcag acagtgctta ttgaaagaaa 11520 agatgcataa ttgatgctgt aaatgctcat cttgaatttg atgatggctg gtgagaaacc 11580 tcagtcggac attcaatttt gattgccatt ggtaagaaag gcagcctttg ttctttgtca 11640 ttatgtggca catgatccta attcacccta tcagctgctt ctctgcacac tttcaagcta 11700 tgtgattgtt atactagaaa gcatctaaat tggccaaact aatgaagact aatctgacaa 11760 agcacgtgtg aatgataaat tgtgaaaaga ccctgaaaat agagcctctt cagtggcttc 11820 ttcccctaag ggtagaagat accagaatcc ctgggcaaga tgaaatagat aaaggaacga 11880 catcattttt atacccagca aatcagaaat attaaagaaa gagaagcaag aatgaagaac 11940 tactactttc atagttcatt cttgcagtgt agcaccttat ttcccataga gacattggcg 12000 aaaccatgtt ttgcgttgcc atagaatagg tgttcagtaa atattttcca gatggcctta 12060 atatgtagta aaacagagag aaatacggaa gcattgacaa gaagtttgtg gataatttga 12120 gggcaaaagg atgtggatag gatcaggttc ataatgcaaa tttgctatta ttctccttag 12180 attaatgatg tcacccaaac ttcacgacct gctttccaag gtatatgctg ttcacagcct 12240 tggaaacatt tagaagtttt taatacttgg agcaagatgg atatatgttt cacattttat 12300 ctaggactta gtaggacttg ggagacatat ctactttgcc agatcttagt atacttatta 12360 cggagcatga cattttaatt ctctttgctt ttgtcctata aagtttagtg ttttattttt 12420 ctcagtgcat atagggagtg aattatttat ataatctgaa aagtactttg aaaactactt 12480 gggaagagat gttgaataaa taagttgttt ttttttttta aattagccta caggatgtaa 12540 gtctggccag gctagtggta tttttggtat cattgtgaaa aatcaaaaac agaacatgca 12600 tttatcaatc cattagtgtg ttctcaggaa tgtgctagac actagggaat ataaaagtag 12660 tataaaacat gactcttgac tttaggacca agcattaaag ccagaaggca acactattaa 12720 tgtaaattca tggtgtgatt atggaacagt ttatgactgt acaacttaat gaaaagttca 12780 ttacagacta aaaatactac atttatttag agagaaggaa aatctgttca gattgaagga 12840 tttgaagagt ggccttcatg ggcaacatgg ctcctgagcc aggacttaag atatggtttt 12900 tttttttttt tttttttgat aggttagaag ggttggagag gtttcatgca aggggttagg 12960 aactgaggac caggaggcgt atcttgagct cactgggttt actgataaca gggagcaggc 13020 agagagtacc aggctgtaga tttgttttcc attggaagct cttcccattt cttattatgg 13080 ttgctgcatg taggcttatc ccttgggtag ggctattgga atggccaccc tgagcctatt 13140 gcttattgga tagtggtggc ttctgtgtga tatttcagca catttctctt ttctgaacat 13200 tatgtaaatt caatcgtaaa actactttct taaacaatgt tccaagaggc ctattaaaga 13260 tgccaacaat atgacttcca ttcaagaata cgatcttgaa tgggctttac aatggcagag 13320 ctgacctgag attacctcct gtactcctgc tctcaagcca tatgctgatg ctgactgtcc 13380 tggtccaata gagccataag gcctcataga acttgagatc atctaccagt ggctttcaac 13440 caagccactg cctttctgct aggtagtgca tagggacatt gggaaataca gttattacaa 13500 gaactggaaa gagttgtagg cttttggtgc ctaaagtcag aaatgctaaa tttctgtggt 13560 gccaggggca gtcctatata agaaattatt atgccacctc aaatgccagt agatccctat 13620 tcaaatattt gagtctcatg tcctcacttt atttataggt gaggaaatgg gaggtcctga 13680 gaagtgacac aactttcttc taggattaaa cttcacagtg tcagtgacag atttataact 13740 caattctttt aattttcttt caagagctct tgttgcagca ccacagtccc tcctattaac 13800 atgggctata actatggaat agcatgttgt ttatctctgt catttttatg gaaggatgat 13860 agttagctgt gttaactatc tgaatgggtg caatgtgcat agagataact ggtacttgac 13920 cagcagttct ttcccctggg aacacacaca gattcacctg taaattaggg ttggcagatg 13980 cctgttgaga tgtcagccac agccaaagct tacagatagg ctgactttct ggaaagggca 14040 tggagtaggc tttggattca cacaaatctg cttgtctgac aggatttgaa tacaactctt 14100 cttatcttta ctatctttgt gactctcaac caattaaact ctctgagctt tagctgcaaa 14160 agaacaggtg atgattctta tttcacaagg aatgagtcaa aacagttcct ggcacatatt 14220 gggcactgca gatatagaga attccctaca gtatcttttt gagagtaaag acttgaaacc 14280 ttcacttata aaagatcctc ctgataacag ttgctatttt tttctcctcc tttccccaaa 14340 caaccaaggg ctttaatgag tccctgaagt gtttattttg tttaaactgt tgagatttcc 14400 ctccttcaga agagtcctgc tggccagaga tgagtttctt ttgactcctc tgtcaatgtc 14460 cctgtattat tgtcatatag taaaaatgga agatttatct agatggttat tagcaggtta 14520 tgaaacttag attttaaagt caagaataaa agccattcct gggtagagat gtttttcaga 14580 gagattgcta ccttgccagc gatgagagag cctccttagg tgaggtgaat acttttggca 14640 agttaaagga taacacaata taatttattt aagtaagttt tttatttggg actaatttca 14700 ggtttgcaga aaagttgcaa aaattgtaga ggtcctgtat gttcctcacc tagtttccta 14760 tgttaacatc cataatcatg atgtatttgt caaaactaag aaaccaacat tagtacaatg 14820 ctattaacta aaatccagac ttcatcctaa ctcccccagg gcttccactc acatcgtttt 14880 ttctgttcca ggattaaatc cataagagtg cactgctttt gattttatga ttttttaaat 14940 actgtgcata tacttttttt atttgggccc tctcacatgt taaactaact ggcctttgta 15000 accagatagc aaattctata acagaaaata caatgatgtt gaatccagca tcatgctgga 15060 cacaaagtat gttctctaaa ctaattaaat ttatcacagc aacaagaaga acaaaatttt 15120 actcagtgta catatgtgta gctgagtcct cattggtaag ctaagaggta ctcataagag 15180 tgggatgact tggaaaaaat ttgattttga atgtgtgccc tgaacattgg tgtaaagcag 15240 gaccccctaa atcaacatta actgagtctg tacaatgtgc ctagcatagt gtgtgcatat 15300 cacacttact cctgataact gtaaggcaca tagccttgag taacttagct gaggaaatga 15360 gaccaaggga agttaagtta cttgcccagg gattcacagc tagtaacaaa actgagatta 15420 acacatgttt ttctggcttc agaacctaca ctcctaatgt ggtattcaat tactcccaca 15480 cttctccact tgcttaatcc ctattcttgg tgtccttttt ctaggtatac agaatttgaa 15540 aactctatat tgtcaaactg cagccaacct ggatacacgg tatatacttt tttgtgagct 15600 ggattaagtt tcagccttga atttgtggat tattttcaaa acctacctaa catctgtaaa 15660 acatgttatt ttttaatatg tagatatcca cgtaaattga ccacaaagct cttcagaagg 15720 tcccataaac caataattaa taaaattttg agacatggct aataacaggc acagaagcat 15780 ctgcaaaggg caggacattg atattgtata ataatttaaa gtattttatt attgtataat 15840 gtgcctgagt tttggataat tgaccttcat ttctcagtct ttacatagtt actgcttttt 15900 taagtgtcac atgagggatg tggaatattc agtgaaacat ttgactaatc tttatatttt 15960 gagtggccca actgaaaatt acccttggtt gccttggaac tctgggaatg atattcaaaa 16020 gtagaaattc ttgcaaatta tttgagcttt ggctctggga agataaacaa catgaataac 16080 taggttaacc agagctgaaa tttctctaac ctataattct aaattcagaa aagaatgggc 16140 tttagggttt tttgtttatt tttgctttga ttacaagttg ttggaagcct agagttagta 16200 tctaataaca caatctatgt aaaacacaaa ttattggctc agaatgatat ctaatttcta 16260 agaagataca agaaggcaat cacgtaaaaa cgtgcttttc ttcatagaaa gaataagctg 16320 ggattggcca aaaggtaatc cctttagagt ctaaggttta gagcattgca tatttttaaa 16380 gaagatatat taccttttag aacatacata agaaaccatt ttctttgctt atatggctac 16440 ataaagttgt catggtttta aactgtgacc ttagatccct tatagaagta attacaggca 16500 caatctgtga atgaagattt gcaaactatg cttcaccaag cctcagggac tattggatgt 16560 ccagaggaca gagccatgtt ggatgtctta tgggccttca gtcctgcaaa gcagtgtgct 16620 ttcatgtttt atacgcagca gttctgagaa aatttaagtt gacaaaacag cctctcttct 16680 tattattttt atttatttat ttattttgag atggagtgtt gctctgtcgc cagtctggag 16740 tgcagtggca tgatcttggc tcactgcgac ctctgcctcc cgggttcaag cgattctcct 16800 gcctctgcct cctgagtagg tggagctata ggtacaggcc accatgccct gctaattttt 16860 gtatttttag tagatacaga gtttcaccat gttggccagg atggtctcga tctcttgacc 16920 tcgtgatctg cctgcctcag cctcccaaag tgctaggatt acaggcgtga gccacggcac 16980 ctggtgcacc agcctatttt tattttttaa agacctgagt gcagtggtgc aatcttggct 17040 cattgcaacc tccacctcct gggctcaagt gatcttctta cctcagcctc ccaattagct 17100 gggactacag gtgcatgcca ccacacccag ctaatttttg tgtgtgtgtg tatatataca 17160 cacatatata tatatataaa tagagacagg gtttagccag gttgtccagg ctgatcttga 17220 agtcctgagc tcaagtgatc tgcccacctc agcctgtccg agttctgaga ttacaggtgt 17280 gaggcaccat gccgagccat cctctcttct aataaaaaaa aannnnnnnn nnnnnnnnnn 17340 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 17400 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnttct aaattcaggc ttacttttgt 17460 aactgctaga ttataaactc ttagagggca aagggctttg tattctctac ttgtgtacac 17520 tcggttagtt tgcttaagca gttacttctg tgtaagcaac attaatgaag tgcttactat 17580 gatcaagggc tataccaagt ccttttttat attgtttaat cccacacaaa acccatgatc 17640 gacctaattc tacacttggt gaaactatga tgtagggagg ttaaataatt tgttcaagga 17700 cccacagctg gtaagtcgca cagtttattc aaacccagat cttcctaatt gcaaatgtgt 17760 ccaactccca tgcttctaac cactgcctat gtggtagttc tttgatattc ctccctctaa 17820 gaagtggagt ttaattcccc tgctccattg aatgtgggcc gaactcaggt gactcatttc 17880 tgttaagtgg agtaaagtgg aagtgaaaat gtgtggcttt agcgactagg tcattcaaag 17940 acattcaaag tggtttctgt cttggttgtt ctgtctcata cctattgggc atttaatctg 18000 gggaaaattt aatctgggga aaatttaatc tggggaaaac tgccatgttt tgagctgttt 18060 atggagaggc taagatgaaa aggtactgtg gatccaacag gcagtttcaa atgaggacct 18120 gaggccctca gaccgacagc cagtgtgaaa ctgaagcctc ttgaccacag cctccatgag 18180 agtaaaagaa tcttgacccc ctagtgaacc acagcctcca tgagagtaag cttcaaaaca 18240 gagccttaac acctagtgga gcctcgagat gactgcagtc ttccaccaac agcttgattc 18300 atgaaagacc atcagccaga gccatccagc taagctgctt ctaggcccct actcctagaa 18360 aataactgtt tgttgttttg actgccaagt gttcagttcc tttgttatgc agcaatagat 18420 aagtaatgca gcctaacact gtccttatca ttttttaaaa aagaaattgt tttaatttta 18480 ctaaatcaca aattttaaag cattgataca gcaaggagaa actttccaga aaaaaatgct 18540 gccaaattta aatagtaaaa tattaatgtc caaaaaacat aatagttaca atgacatcta 18600 ggattgagga ttttgtaagt caaaggtcag ccacttaaaa aattcataat tttaaaagga 18660 aggatattaa taataactgc attattgaac atagatagca ttttgaactt ttaagaaatc 18720 ctcatgggaa aactcaggaa atattgtttg gtaagttatc actcataatc ttaaattgtt 18780 aggcgcatgt ttgcactttc catgattgaa agaggaatgt aaagcaaagt tgaattttaa 18840 cctcttccct agtgatttta ctcagctttt caaaggggtc ctgaaagctc agaggtcaag 18900 tcatttcttg gtttgctctg cctgacaaat tgcattaact ctgttttata gccactttca 18960 gtttaataaa tgacttggac tttgattaat atctttagtg cttaagccca agaatttgta 19020 taagactttg ggatatagta ctgtaaattt atctaaagat ggacactgga aggtagaagg 19080 agatatatta gtgttggttt gggtacatgt ctaggtactg aatttggatc atcataagtc 19140 cttacagaag atacttgttg atttgtcttt taaaaaaaaa gtgaaagtga ttttttaata 19200 tatttacaaa gtgatttaag tgatttaagg aattcattca tgaagtggat atggctagtt 19260 cttgtttagt attcagaatg actgtaaaat agaaatgctg attttccttg cccagattgt 19320 agaacacaga tcaaaccctc ctagtccttc ccttaaatgt tttttctcca tgcagcttac 19380 accctgaatt ctcaaaacat ttgttatatt gaactggact ggatagtata tgcctgaccc 19440 tgattcatgg gattatgctg caagggaata taaagatgaa tattgatagc ctgagtgtga 19500 aaattcataa ttactctcat cctcgttcat taattcattt gttcattaac tcataaacag 19560 actaattgat tcaacagata tttattgaac atttacactt tgcccagcag agcactggac 19620 taggtgctag cacagtataa taagcaaccc agaaatagcc tctgccctgc tggatttcat 19680 agtctaagat ggagaaaggc attaaccaag tgtaatttaa aatcgtttta agtaatgtga 19740 aataaatata tatgagaacc tgactcaggt tgggatttga tgattaggga aagctttcaa 19800 aaaagggata tttgagatct aaataagagg gagaagaaag agacaatggc tagagaaaaa 19860 ataggatcca ggaagatact tagtacttct gagaactaaa aacagccaag tcagtgtagt 19920 cagagttcaa agagggagaa agtacatatc taagaagaag ctagaaaagt aagaagggac 19980 tacgtcttac acaatgatgt aggctgtatt ttagttttta cttatcttaa gagcaataga 20040 agaccattga agggtttgaa gcagggagtg acataatcag gtctgcattt taagttcacc 20100 tgctctgtta tgaagcatga ctggaggagg atggaaagag atattcaggg agctggatta 20160 taagtctgtt gtaggccaga ggtattggta gcttggaccg gggtgatgat gctgaagatt 20220 gaaaggagtt aatatattta taatatattt gtgaagtaaa gttgactgta cttagtgctg 20280 acttagatag tattggtgag ggatgtcatg gtaaattcca aggtattggg cttcttcaac 20340 tgaatgggaa acactagagg gagagcaggt aaaagttgag ggaaagtgag ggacagtagt 20400 tcattttggg gatattttga tttcgatgcc tttttaagac atcctcaagg agacacagtg 20460 cagtcttgag tcttggatca gaggagatac ctgaatgtat aaatttgtaa gacagtggtt 20520 tatgcacact attgaagcca cagaggtaaa tcagatgatg tacagagtgc aaatgaagtg 20580 agagaagaaa gcataagtct gagccatgag aactctaaca tttaaaggcc aagtggaaaa 20640 gttgacaaga gtgggaattg tgactagggt agatgccaga gtggcatctc agaggccaag 20700 gaaagagaat catttaaggt gctgatgagg ggtaaagtaa gaaggtcctg taaatgtccc 20760 cttggattaa taaaattgat gttttgaaag actttaagga gagtgagttt gttgtagtga 20820 tggggacaga agccagaatg aaatgtcatg ggaaatgggt gggaagtctt gaaagagaga 20880 caatgaatat aggtaattca agatatgtgg tcaagggaaa caaaaaggat aaggctttaa 20940 ctagaggagg aaatagagtt aaaggaggag gctttttgtt tttgttttgt tttgttttgt 21000 tttgtttttg agatggagtc tcactttgtc gctcacgctg gagtgcagtg gcgcgatctc 21060 ggctgactgc aagctccacc tcccaggttc acgccattct cttgcctcag actcccgagt 21120 agctgggact acaggtgcct gccaccatac ccggttactt ttttatattt gtagtagaaa 21180 cggggtttca ccatgttagc caggatggtc ttgatctcct gaccttgtga tctgcccgcc 21240 ttggcctccc aaagtgctgg gattacaggc gtgagccact gcgcccggcc aggagttctt 21300 tttttttttt ttttttaaag atgggagaat tgagcacatt taaacactaa tggggaagac 21360 cagtggggag gatcaggggt ggcctgaaga tagacagagg gtggataaat aatcatatag 21420 gattcctgag aagatagaag aagttggatc cagagcacag cagggggaat tagttggcct 21480 tggagaggag agatgatctc taccctctgt tctagaagaa agccaaaggt gatgtgtgca 21540 gatgcagagg tgtgtttgat gtggtggagg caagtcaaag gagtttttgt tcgatgcctt 21600 atacctgctc cagaaagcag ttgagtcacc aactgagaga gggagagaga aaggggctag 21660 catactggga aagaaagggg atcatttcag atatttgagg aggacagaga aagtttgaat 21720 atgaaaggga gtaaatgagt aaaatttagt aggatttcta gtcatttttt gaaagctcag 21780 ctgaggctga tgatcatgaa ttcatggtga taccattgtt agaattatta taaaatatat 21840 aataatatat tatatattca cctccttttg gaggtgctca gcagtttact agacagaaaa 21900 gcagggtcat ctaggcttaa aattttgtca gagaggtatg atgaaaagat tgcaaaggag 21960 attaggatat tggcatgggc aagggagctt ctagagtgat aaaccaggaa tctaagcctg 22020 ctagtggggg acatgtagac aggagaagga gagtataaag atctttgtga aggctggagg 22080 aaatttgtaa tcagagtggt tgattaaaca agacagaagt atagcagtca gtgatcagca 22140 caggatgctg caccccagat caattaaatc tgtatctctg catacagggc ccatttcagc 22200 ttctcaggag atcccagtgc tttccttaag ggagaatatt gatataactg ttattaagac 22260 ttgtgaaaaa gatattagca atgtgaaatc aagacaaaaa cacaaacaca gaaagaagtt 22320 agacaaaaaa aaccaacaac acagaaatta cacattttct ttttcacaaa tcaaagtcga 22380 attcatgggc cttcctccct ggctcattct ccctgacatt agaagtacaa agggagtaag 22440 taaagtcttt atggggaaga tggtataatt aagcaacaat tacctaggga ccagatgctt 22500 ttgaatttga ctgatggaaa cagaagcgtg gtgaatttgt tcactacagt ctttttggag 22560 gggcaacact cttggctcac ttggcatgag gtagtttcag tctggctaca aagatttgaa 22620 tgtgggactt gagtttctaa aaggggacta actggccttc tgttagccag gattctcgga 22680 cttggtggct atatcacggc ttatgctgtc ttggaatggt cttgggccca gttgaaattt 22740 cttgaaatta catatgaaga ttcattaatg tattacttgg aattcagtga caaggatcat 22800 cattgccagg tttcctagtt aggaaaactt acctccattc cttccagtta aatagaagac 22860 cattgtatag ttcatttctg gttaagtaga gtatttatga aatgtgtagg gcttataggc 22920 ataactattg ctaaagaaag cccagtaaag cttgacattc cctctgttgc ccttgtctgt 22980 ctttccataa atttaatgtc aagagcattt tttgagaaga tgatcacagg atgattcagg 23040 tagacatgga gcaggttgtg aaaacacttg aatgtttcac caatgcatta gggtttccag 23100 agaaacagaa ccagtagggg tgtgtgtgtg tgtgtgtgta gatttatttt aagacattgg 23160 ctcacacaat tgtggagact ggcaagttca aaatgtgcaa ggtgggccag taggttggag 23220 acccagagaa gagctcatgt tgcaggtcaa gtccaagtct gctgcagaac ttccctttgc 23280 ttggtaggtc agtctttggc tctattaagg cattcaactg attggagggc agtttacttt 23340 actcagagta catcatttaa aattttaatg tcatctaaga acactctcat agaaacattt 23400 aggatattat ttctgaggac tctgttctgt tccattggtc tatatctctg ttttggtacc 23460 agtatcatgc tgttttggtt actgtagcct tgtagtatag tttgaagtca ggtagcgtga 23520 tgcctccagc tttgttcttt tgacttagga ttgtcttgga gatgcgggct cttttttggt 23580 tccatatgaa ctttaaagca gttttttcca attctgtgaa gaaactcatt gggagcttga 23640 tggggatggc attgaatcta taaattacct tgggcagtat ggccattttc acgatattga 23700 ttcttcctat ccatgagcat ggtatgttct tccatttgtt tgtgtcctct tttatttcac 23760 tgagcagcgg tttgtagttc tccttgaaga ggtcctttac atcccttgta agttggattc 23820 ctaggtattt tattctcttt gaagcaattg tgaatggaag ttcattcctg atttggctct 23880 ctgtttgtct gttactggtg tataagaatg cttgtgattt ttgcacatta attttgtatc 23940 ctgagacttt gctgaagttg cttatcagct taaggagatt ttgggctgag acaatggggt 24000 tttctaaata tacaatcatg tcatctgcaa acagggacaa tttgacttct tcttttccta 24060 actgaatacc cttgatttct ttctcttgcc taattgccct agccagaact tccaacactg 24120 tgttgaatag gagtggtgag agagggcatc cctgtcttgt gccagttttc aaagggaatt 24180 tttccagttt ttgcccattc agtatgatat tggctgtggg tttgtcataa atagctctta 24240 ttattttgag gtacattcca tcaatagcga atttattgag cgtttttagc atgaagggct 24300 gttgaatttt gtcaaaagcc ttttctgcat caattgagat aatcatgtgg ttcttgtctt 24360 tggttctgtt tatatgctgg attatgttta ttgatttgcg aatgttgaac cagccttgca 24420 tcccagggat gaagcccact tgatcatggt ggataagctt tttgatgtgt tgctgaatcc 24480 ggttttccag tattttattg aggatttttg catcgatgtt catcagggat attggtctaa 24540 aattctcttt ttttgttgtg tctctgccag gctttggtat caggatgatg ttggcctcat 24600 aaaatgagtt agggaggatt ccctcttttt ctattgattg gaatagtttc agaaggaatg 24660 gtaccaactc ctccttgtac ctctggtaga attcagctgt gaatccatct ggtcctggac 24720 tttttttggt tggtaggcta ttaattattg cctcaatttc agagcctgct attggtctat 24780 tcagggattc aacttcttcc tggtttagtc ttagaagagt gtaagtgtcc aggaaattat 24840 ccatttcttc tagattttcc agtttttttg cgtagaggtg tttatagtat tctctgatgg 24900 tagtttgtat ttctgtgggg tcggtggtga tatccccttt atcattttta attgcgtcga 24960 tttgattctt ctctcttttc ttctttatta gtcttgctag tggtctgtca attttgttga 25020 tcttttcaaa aaaccaactc ctggattcat tgattttttg gagagttttt tgtgtctcta 25080 tctccttcac ttctgctctg atcttagtta tttcttgcct tctgctagct ttcgaatgtg 25140 tttgctcttg cttctctagt tcttttaatt gcgatgttag agtgtcaatt ttagatcttt 25200 cctgctttct cttgtgggca tttagtgcta taaatttccc tctacacact gctttaaatg 25260 tgtcccagag attctggtat gttgtatctt tgttctcatt ggtttcaaag aacatcttta 25320 tttctgcctt catttcgtta tgtacccagt agtcattcag gagcaggttg ttcagtttcc 25380 atgtagttga gcggttttga ttgagtttct tggtcctgag ttctagtttg attgcactga 25440 gagacagttt gttataattt ctgttcttgt acatttgctg aggagtgctt tacttccaat 25500 tacgtagtcg attttggagt aagtacgatg tggtgctgag aagaatgtat attctgttga 25560 tttggggtgg agagttctat agatgtctat taggtctgct tgctgcagag atgagttcaa 25620 ttcctggata tccttgttaa ctttctgtct cgttgatctg tctaatgttg acagtggagt 25680 gttgaagtct cccattatta ttgtgtggga gtctaagtct ctttgtaagt ctctaaggac 25740 ttgctttatg aatctgggtg ctcctgtatt gggtgcatat atatttagga tagttagctc 25800 ttcctgttga attgatccct ttaccattat gtaatggcct tctttgtctc ttttgatctt 25860 tgatggttta aagtctgttt tatcagagac tagtattgca acccccgctt ttttttgttc 25920 tccatttgct tggtaaatct tcctccatcc ctttattttg agcctatgta tgtctctgcg 25980 tgtnnnnnnn nnnnnnnnnn nnntggtaat cttcctccat cccttatttg agcctagtag 26040 tctctgcgtg gagatggtct cctgatacag cagactgatg gtctggactc ttatccagtt 26100 tgccagtctg ttctttaaat tggagcattt agtccattta catttaaggt taatattgtt 26160 atgtgtgaac ttgatcctgc cattatgata ttatctggtt attttgctcg ttagttgatg 26220 cagttccttc ctagcctcga tggtctttac attttggcat gtttttgcaa tggctggtac 26280 cagttgttcc tttccatgtt tagtgcttcc ttcagggtct cttgtaaggc aggcctagtg 26340 gtgacaaaat ctctaagcat ttgcttatct gtaaaggatt ttatttctcc ttcacttatg 26400 aaacttagtt tggctggata tgaaattctg ggttgaaaat tcttttcttt aagaatgttg 26460 aatattggcc cccactctct tctggcttgg agagtttctg ccgagagatc tgctgttagt 26520 ctgatgggct tccctttgtg gataacccga cctttctctc tggctgccct taagattttt 26580 tccttcattt caactttggt gaatctggca attatgtgtc ttggagttgc tcttctcgag 26640 gagtatcttt gtggcgttct ctgtatttcc tggatttgaa tgttggcctg ccctactagg 26700 ttggggaagt tctcctggat gatatcctga agagtgtttt ccaacttggt tccattttcc 26760 ccctcacttt caggcacccc aatcagacgt agatttggtc tttttacata atcccatact 26820 tcttgcatgc tttgttcatt tctttttctt cttttttctt ttggtttctc ttctcgcttc 26880 atttcattca tttcatcctc aatcgcagat actctttctt ccagttgatc gagtcggtta 26940 ctgaagcttg tgcatttgtc acgtatttct cgtgtcatgg ttttcatctc tttcatttcg 27000 tttatgacct tctctgcatt aattactcta gtcatcaatt cttccacttt tttttcaaga 27060 tttttagttt ctttgcgctg ggtacataat tcctccttta gctctgagaa atttgatgga 27120 ctgaagcctt cttctctcat ctcgtcaaag tcattctccg tccagctttg atccgttgct 27180 ggcaatgagc tgcgctcctt tgccggggga gatgcgctct tattttttga atttccagct 27240 tttctgccct gctttttccc catctttgtg gttttatctg cctctggtct ttgatgatgg 27300 tgatgtactg atggggtttt ggtgtaggtg tccttcctgt ttgatagttt tccttctaac 27360 agtcaggacc ctcagctgta ggtctgttgg agattgcttg aggtccactc cagaccctgt 27420 ttgcctgggt atcagcagca gaggctgcag aagatagaat atttctgaac agcgagtgta 27480 cctgtctgat tcttgctttg gaagcttcct ctcaggggtg tactccaccc tgtgaggtgt 27540 ggggtgtcag actgccccta gtgggggatg tctcccagtt aggctactca ggggtcaggg 27600 gcccacttga gcagggagtc tgtcccttct cagatctcaa cctccgtgtt gggagatcca 27660 ctgctctctt caaagctgtc aaacagagtc gtttgcgtct gctgaggttt cggctgtgtt 27720 tgttattgtt tactgtgccc tgtcctcaga ggtggattct acagagacag gcaggtttcc 27780 ttgagctgct gtgagctcca cccagttcga gcttcccagc agctttgttt acctacttaa 27840 gcctcagcaa tggcaggcgc ccctccccca gcctcgctgc tgccttgccg gtagatcaca 27900 gactgctgtg ctagcaatga gggaggctcc gtgggcgtgg gaccctcccg gccaggtgtg 27960 ggatatgatc tcctggtgtg cctgtttgct taaagcgcag tattggggtg ggagttaccc 28020 gattttccag gtgttgtgtg tctcagttcc cctggctagg aaaagggatt cccttccccc 28080 ttgcgcttcc caggtgaggc aatgcctcgc cctgcttcag ctctcactgg tcgggctgca 28140 gcagctgacc agcaccgatc gtccggcact ccccagtgag atgaacccag tacctcagtt 28200 gaaaatgcag aaatcaccgg tcttctgtgt cgctggcgct gggagttgga gactggagct 28260 gttcctattc ggccatcttg ctccgccccc ccttgttgag gttttttatc ataaaagtat 28320 gctgaatttt gtcaaacgct ttttctgtgt ctagtgaggt gatcatgtga tttttgtttt 28380 taattctgtt tgtgtggtat atcacattta ttgactcagg tatggtaaac ctacatccct 28440 ggtatgaaac cactacctcc ctggtatgaa acccacttga tcatgatgta ttatcttttt 28500 tgaaatgctg ctggattcag ttagctacaa ctttgttgag gatttttgca ggtatgttca 28560 ttagggatat ttgtctgtac ttttagtttt ttgttatgtc ctttcctggt ttagatatta 28620 gggtgatact ggcttcatag aatgatttag tgagcatttc ctccttttct atctttttga 28680 atagtttcag tattcaattt ttctttaaat gtcagataga attcagctgt gaatccatct 28740 gctcttgggc tttttttctt ggcacttttt ttttattact ctttcagcct cactacttgt 28800 tatttgtctg ttcagagttc ctgtttcttc ctgatttagt ggaggagggt tgtaaatttg 28860 caggaatttg tccatctcct ctagattttc tagtttgtgt gcatataggt gttcataata 28920 accttgaatg atcttttgta tttctgtgat atcggttgca atatcttgtt tcatttctta 28980 ctgagcttat tcagatcttc tctcctcttg tttaatttca ctaatggttt ttcagtcaat 29040 tttgtttatc ttttcaaaga accagctttt tgtttcactt atcgtttgta tttttgttgt 29100 tattgctgct gctgttgttt ctgtttcatt tagttcttct cttatttggt tatatctttt 29160 cttctgctgg gtttgggttt tttttttttt ttttttttct tgtttccctc gtaccttgag 29220 gtgtgacctt agattgtcta tttgtgctct ttcagacttt ttgatatagg catttaaaac 29280 tatgaaattt cctcttagca caacttttgt tgtatccctt aggttttgat aagttttgtc 29340 accactatca ttttgaaaga atttttaatt tccatcttga tttcattgtt gacccaaagt 29400 cattcaggag cagattattt aatttccagg tatttgtata gttttgaagg tttcttttgg 29460 gattaatttt catttttatt ccacagttgt ctgacaggat acttaatatg attttgattt 29520 tcttaaattc attgagactc attttgtggc catggtctgt cttggagagt gttccatgtg 29580 ctgatgaaaa gaatgtatat tctacatttt taggtagact gttctgtaag tacctgtaaa 29640 gtcaatttgt tccagggcat agtttaagtc cattgcttct ttgttgactt tctgtcttga 29700 tgacatgtct agtactgtca atggagtacc aaaatcccac actattatta tgttactgtc 29760 tatcttgttt cttaggtcta gtagtaattg ttttattaat ttgggagctc cagtgttaga 29820 tgcatatata tttatgattg tgatattttc ctgttggact aatcctttta tcattatata 29880 atgttcctct ttgtcttttt tttttttttt cactgttgtt gctttaaagt ctgttttgtc 29940 tgatataaga atagctactc ctagactggg cgcagtggct cacacctgta atcccagcac 30000 tttgggaggc cgagacaggc agatcacaag gtcaggagtt ctactaaaaa tacaaataaa 30060 ttagccaggt gtggtagtgt gcacctgtag tcccaggtac tcaagaggct gacgcaggag 30120 aatcgcttga atccaggagg tggaggttgt agtaagcaag attgtgccac tgactccaac 30180 ctgagcaaca gagtgagact ccttaaaaaa aaaaaaaaaa aaaaagggct actcctgctc 30240 acttttagtt tccatttgtg tggaatatct ttttccacct ctttacctta agtttatgtg 30300 agtttttatg tgctatgtgg gtctcttgac aacagcagat acttggttgt tgcatttctc 30360 tccattctgt cattctgtat cttttaagtg gagcatttag gccatttgct ttcaatgtta 30420 gtattgacat ataaggtact gttctattca ttatgttagc tgttgcctaa atacttttta 30480 aaattatgtt attgctttat aggccctgtg agatttatgc tttaagaagc ttttgtttga 30540 gtgtatttca aggtttcgtt tcaagattta gaactccttt aagcagttct tgtagtgctg 30600 atttggtagt ggcaaattcc cttaacattt gttaggctga aaaatacttt atctctcttt 30660 catttctgaa gcttcgtttt gctggatgca aaatttttga ctgacaatta ttttgtttaa 30720 atatttctca aggtttctct tgagataacc tgatgactga gtgtctaggt gattatcttt 30780 gcagtgaatt tcccaaaagt tctttgagct tcctgtatgt ggatatcaag atctccagca 30840 aggccaggga agttttcctt aatattccct taaataagtt tttctaactt ttagatttta 30900 cttcttcctc aggaacacca tttattctta ggtttgatca tttaatataa tcccaaattt 30960 tgtggaagct ttgttcattt tttaaaattc ttttttcttt gtctgattgg gttaattcaa 31020 aagtcttatc tttgagctct gaagttcttt cttcgtgttc tagtttgttg ctgaaacttt 31080 ccactgattt ttgtacttcc ctaagtgtgt ctttcatttc cagaagttgt gaatgttttt 31140 ctttatgata tctatttctt tggaaaaaaa tgcgttcata ttctgtattg gtttttaaat 31200 ttatttaatt tttttttttt gccttttact ggtaactcct tgagtagctt aataactgac 31260 ctgctgaatt ctttgtctgg aaattcagag atttcttctt ggtttggatc cattgttgtg 31320 gaactacagt agtctttggg ggttttatag aaccctgttt tgtgatatta ccagaattac 31380 ttttctggct tcttctcatt tgggtagact attacttaac attgttcttg tggactgttt 31440 tttttttttt aaatttctta ttttttcttt gttaaggatc agactctaat gtttatttta 31500 gcctaatttt agtcttggtg cttgtagggg tgaagactct gtatgagatc cttagttata 31560 gagtctttat gcactggttt tccccagtgc tggttttagt agttccattc ttgatatgtg 31620 ggtgaattca ctgtctcctg tgaagttgga atggcaggga tcccttgacg cttatgtcgt 31680 cctctcatgg tatacagttt atttactgtt cttttattta ctgagttgat gattcaggct 31740 tcaggacaac tggggaggta tccccgggca ggcaccagct gtggctaagg caagtgggta 31800 gatgtaatac ccagtgatga gccgaggaca cagccttaat gagggtggct ggaggagctc 31860 tcagttaggt gtgctgaaat tttatcaagg tgaagagtgg gagctacctc acctcccctg 31920 ccaggtcaga aagaaagcta ttcacctcac agcctcactc ctgtccaagc atttcagcta 31980 ttcagatcag tcaggcacct cttttcatct ataggaatgt tgttgctcca agtagggagg 32040 aattgtgact ctgcctctca tgcaggcctg aatctggggt gtgctcttct tgtgggttat 32100 actcaccttg gagagttcca gaaaggctgt ctacaggtgt gtccttgctg cattcctgtg 32160 gaggaagccc cagctatgtc tgcggtggag tgccaggggg aacaaagact ccttttccaa 32220 ggcccttcat ggtcacagag gctgcctgct tgttggggta gaggtgcaga ctttccctac 32280 tgcacccagc actgcaattg ggtctctgct gtgagaaact acccaccagc agaaagatct 32340 gaaactccta ctattcagat tattttgtcc cacatagtga ttccttgatg tggtgctctc 32400 ccctttccac tagagatggg cttccggaga gccagattgc agtgactgtt attgttcttc 32460 tgggtttagc catccaatgg agttaccagg ctctgggctg gtgctggtga atgtctgcaa 32520 agagacccgt gatctgatca gtcttcaggt cttctagcca tggataccag cacctgctgt 32580 ggtgaaggtg gcaggggagg gatgtagaat ctgtgagaat ccctgattgt agataggtat 32640 agtgtgctga ctttctcaaa tgctagttat gctagtagtg aagttgtcat gtggacagac 32700 tcaggacctc tggttagcca ggatgttgca ggcagtggta ttagctgttg tcttctcctt 32760 cctgggaaca atattattgt catgagtatg gcctgaattg gttggcctcc agccaggagg 32820 tggtgtcttt tgtgtttggc tgccaaggca gatagaaaaa tgccatcaag tggggccagg 32880 atgagctgag actcttcttg ggctaggctt gtcacagcca ctatgtagga tggggaggat 32940 ggttttcagg ccgatggggt tatgttccag aggggattat gactgcctct gttgcacaaa 33000 atagttcacc agggaagtgg agaatagcca gtagtgaaaa gcttcaccca gctcccacac 33060 agttggtgag cccaatctca ctttgcagtg ctgtgttaac agcaccaagt ttagatccag 33120 gcatcctgct tgtggaactc agtcttgctc caggccatat acttccccac tgagaaagca 33180 agcaaggctt tcaggccaca cccctccctg tctgcccata atggcaggag cctggttcct 33240 gtgctcatat ctgctgcagt tcccatccac ccaccagatt ctgttcaagc aggttcacgc 33300 ccactcaaaa ttatcacaaa attcagttgg aggcttcttt caccttgtac cccctcccta 33360 attctgctgg ctgccttccc cgagggcccc tgtgatatat agtcaggaat ggcttccctg 33420 ggtttgagct ggagactggg agtgcctaca agactctttc tgctgctgct tctacttttg 33480 tatttcacaa ggttccctaa atctgttcca gctctaggta aggttgagtc cttctctcat 33540 gatttgcatt ttcagattcc ccagtgagga ggtgtgtttg gaggcaggtt tcccccactt 33600 acactttggg aactcattgc tttttgcctc tctcacagtt tgcagcagca tgtcacttct 33660 ttcaacggat ctgtgaattc tttccatttt cttgatatga tcctgtggtg gttcttggag 33720 aaaaggttca cagtataagt ctccacacac tgttctgtcc atccaagtgg gagatgtatg 33780 ttagccttgt ctcctatccg ccatctttct gctgtcaaat ccttctcttt agatagctga 33840 cataccatct tttgtttctt ctgacttggt tctattcact gacattcctc tctatcaagt 33900 ggatttttga actttcatgg aaatttattc cctatttata tggaaataat tcccaattta 33960 tatgaaaagc ttacaaagtg attcattaac caagtattta ctgaggtgct aaaattatac 34020 actaatgcaa gagtggctgg caagtccttt gccttcatgg ggattacatt ctcttgtaaa 34080 tgtcacatga tggccactag atttaggaat aaaggactcc agcatgaaac actgacactt 34140 ctgctggaga aatattttac aaaccatata tattgaagcc taaactctgg tttattggta 34200 aaggagtagc actgatacta gaattttgtg atcaatatgt tgggataaga agtcagaaga 34260 cttagatctg tgttcttttt ctcctgctgg ctataggttg ttttaatctc tgagctgcaa 34320 tttcctcatc tatagaatag gttagaccag attagtggtc ttcaactttg gctgtatatt 34380 agaatcatct tactcttgaa catttaaatt agaaatttca ggccaggtgc agtggttcac 34440 gcctgtaatc ctagtatttt gggaggcaga tatgggcgga tcatgaggtc atgagatgga 34500 gaacatcctg gccaacatgg tgaaacccca tctctactaa aaatacaaaa attagctggg 34560 catggtggtg cacacctgta gtcctagcta ctcgggaggc tgaggcagga gaatcgcttg 34620 aacctgggag gcggaggttg cagtgagccg agatcgtgcc actgcactgc agcctggtga 34680 cagagcaaga ctccgtctca aaataaataa ataaatgaat taaaattaaa attagaaatt 34740 tccctgggtg aggaggaagg cagaggtatt tttaaagctc tcaggtgata caattctgtt 34800 ttaaggtagg actaaaaatc atgggactac gtcagaagtt ctaattagaa atctacaggt 34860 tagttttctc cgggcatgtg tatagtgctt aaatgtcttt taaatttgtt accaacatag 34920 agaaaaaaaa gatttctagt ttcccttgaa aaatggaaat attaggcaac agttgggctt 34980 atgtttctga gtggtaaaaa ttaaacaaag taaacgagtc tccatttcat ttgttcctgt 35040 tgccttcctg gctcttgaag gcattgtcat ttgtgaaaac taaactagat ggtctttaaa 35100 gtctccaatt atttgaattg cttatttcca cagccagaaa agagatggta aacaaactat 35160 acctttatct ataagctagt tggtttgtga aatcaaaagg gacttaatct ttgaatatgg 35220 aaaaatccca gcttccagtg gaagaggaac tccatctcat taatagcagg actccacaga 35280 ctgctataga atagacaccc acctggggct aagagggagg gaggcggaag aggacttaat 35340 tcattttctg gggattttta atgaagcttt cccctctttc attatttctt atttgggagc 35400 ttgatcatta gttgggatgt gactggcttt ccctagggag caaaaaggag attagcagag 35460 gttttgctcg cttcttcctg tgatttactg tgggaagcct cccaggttct tcccttcgct 35520 tctctatgac cttcatcttt atggtttctt gctgtgtctc tctgagagca agtacctggg 35580 tgaaaaaggc tgagtgtgtg gtttattggc aactgcctgg cattggattt aagtgggtat 35640 atttgaatta ctagaatttt acgttttata ggttcaaaat atgcacttga attttgtagg 35700 acctcttacc caaattgaat aatcctttgt gccttgttaa attttaaaca gtcacactat 35760 caacattatg acatatggta tatatgatgg caataataaa aataacactt attgtccact 35820 ttaatgtgct aacagtgttc caagtgattt gcataaatgt caaatttgtt ccacacaatt 35880 atcctatgaa ctaaatgtta ttgtttcctg gtttataggt gaggaacaca gaggctcaaa 35940 gcagctattt ggtttctctt atttcaaaat taggggaagt gagatacatt aacctgtata 36000 accagacctt gttaactgtt tttggtaaat tccaatgtgt attgattttc acaaagacaa 36060 agcacaccac tgttatatta aatattaatt ttttcatagt ccctcaaggt gcttactggc 36120 tatattgtta ctgtcttttg atgttgttta tacatggtgg attacagaat tccatgaaca 36180 tgaaaaatct tgactttatc ctagcttatt acctattctt accccctgca aagtaaaaag 36240 ttcacaatag cattagtaag ccaagcaaac tacttattag ccacatgaac ttactagcct 36300 ctctgcctcc gtttccttgt tgggaaaatg gacaatacct aactcaactc ataaggatat 36360 ttctagaatc aggtgtaata tcaaataaaa atatatttca tttttcctag aagataccca 36420 tgtatatctt aggtactgat gcattcatag tgatgcagga catacaatgt ttattctttt 36480 ccttagcaac aactatccat ggagattttt ccactttaga gatttaattc cattaaaggt 36540 ttttagattg attggacaat gagaatgttt ttgtctctct gaaactgagg ctgaaagttg 36600 atttcattct cacacttgtt cccagcaaag gctccttcca tgctatcacc atctaactgc 36660 tgccaggctc ttttcagtgt agatggacaa cacgatggat taatttctct tgctgaagtc 36720 atttctactc ttcattgccg aaaggttgct tatttgtgtg ctcagcttct tgaataagtt 36780 ggcacattca gtggatctcc ccttgtatag ctcatactca cttgtcagta aaagatttgt 36840 tgtgtgcagg aagggagttg gggggacaat agctcctgcc tgctaagcaa tctaaattat 36900 gagttgagcc tttcattcat tgctttatat gtggctgtat gcttgctatt aactaatttt 36960 tgctgtttat gggaaaaata gttgcctttt gaaaagaaaa aactgaaaag aggcatccat 37020 attcttctca ggtcttagtc catgggtgag tgggtgtgtg cataaacata tctatataca 37080 tgtgcatgga aatatacatt tatatacatg tggtatatgt gcatacttag tgtaactaat 37140 gctatatata attcatgtgg caaattcaat aaggacaaca gtaacaaaaa ggccagggaa 37200 tgtaatcttc tcccctgaat acttcaggtg cccaagaaac ttatttgtct ttcatattgt 37260 ggagtaaata aagttttatt ttaaagcaac tttctcagat cttttaaaaa aatgttttta 37320 ggtacagggt cttgctctat tgcccaggct agagtgcagt ggcatgatca tgactcattg 37380 cagcctggaa ctcctgagct caagtgatcc tcctatctca gcctcccaag tagcagggac 37440 tacaggtgca agccactgta tctgtctaat ttttttcata ttttttggac atgggatctg 37500 gctatgttgc ccaggctggc cttaaactct tggggtcaaa caatccttct gcttctgcct 37560 cccaagtacc tgggattaca ggcatgagcc actcagatcc ctttgtgtgg cacgtataaa 37620 accaatattt taaaactcag agcaatcttt tttaatcctt ggagtaacct tatgaagata 37680 gtaaataaca aatgctctga gatctataat ctctactact ttaaagattt atttaaaatt 37740 ttatgaattt ttattttcat aattagtatt ttatatagtt atagtaaatg gtattttata 37800 aatatataaa tacattaatg tttttaaaat ttattttgga gttttatgtt ggcttcaaga 37860 taatgttaag tcttttaagg gttacttatt aatacaattt tcagctttta tttgttcaaa 37920 ctcaagtaat gaaaatttct gcttaaagga gaaggtttta cttccagcct cttcaggatt 37980 aacttgaaag aaaatgtcgt taaactaaaa aaactataca tattacacca ccaaatacct 38040 gctttctggc actaataaat tagttttttg aatgcgtcca ccttagtaat gaattatctg 38100 cttgcatata cttctgtttt aaaggataga taccatttgt tacctgtgtt tcagtcacag 38160 atttttacta aactttgctc cctggtataa aacacagaat gggaatttgc agtataattg 38220 tgaaaaaact ccatttgttt cctatattaa gagcctataa gcaaggtaga gatggttaac 38280 tgaggaagtt gaatgataac atccaagcta agagccagtt caagaataca atcccattct 38340 caatagccac agacagaata aaatacctag gaatacagct aatcaaggag gggaaagacc 38400 tctacaacaa taattataaa acgttgttca gagaaatcag agatggcaca aaaaaataga 38460 aaaacattcc atgctaatgg ataggaagaa tcaatattgt gaaaatagcc atactgccca 38520 aagcaattta cagaatcagt gtatgtcaaa ctaccaatga cattctccac agaggcagac 38580 aaaaactgtt taaaaattta tactgaacca aaggaaagct caaatagcca aggcaaccca 38640 aagcaaaaac aacaaagctg gtggcatcat tttatctgac ttcaaatcat actataaggc 38700 tacagtaacc aaaacagcat gtcgctggca caaaaacaga cacatagaca aatgaaacag 38760 attagagagc ccagaaataa tgccacacac ctacaacaat ctgatctttg ataaagctga 38820 caaaaacaag aaatggggaa ggactctcta ttcaataaat ggggctggga agctagctag 38880 ccatatgcag gagattgaag ctggacccct ccttacacca tataaaaaaa tcaacttgag 38940 atacattata aacttaaatg taaaacctaa aactataaaa aaaaccctgg aagataacct 39000 aggaaatgac attctcgaca taggacctgg caaagatttc atgacaaaga tgtcaaaagc 39060 aattgcaaca aaaacaaaaa ttgacaaatg gaaagtaatt aaactaaaga gcttctgcac 39120 agcaaaagat ctatcaacag agtaaacagc ctacaggatg tgagaaaata tttgcaaact 39180 acacatctga caaaagtctg gtattcagaa tccataacaa acttgaacaa atcaacaagc 39240 aaaaaacaac ccaattaaaa agtgagcaaa gaacattagt agacattttt caaaggaaga 39300 catacatgtg gccaacaagc agatgaaaaa atgctcagta tcactaatca ttatggaaat 39360 gcaaatcaaa accacaatga gataccatct cacaagtcag aatggctatt atcaaaaaaa 39420 aaatgaaaag cagttgcttg tgaggttgta gagaaaaggg aatgcttata aactgctggt 39480 gggaatgtaa attgttcagc aattgtgata aacagtttgg tagtttctca aagaactcaa 39540 agtagaatta ccattagacc caacaatccc attattggac ataaactcaa aggaatataa 39600 atcattttac cataaagaca catgcatata tattttcatt gtggtactat gacagagaca 39660 caataacaaa gacatagaat caaactaaat gtccatcaat agtagactgg ataaagaaaa 39720 cgtgatacat atataccatg gaataccacg caaccataaa aagaaatgag atcatgtcat 39780 ttgcagcaac atggatgaag ctggaggcca ttatcgtaag tggactaaca caggaacaga 39840 aaaccaaata caacatgttc tcatttataa gtggaagcta aacattgagt acatatggaa 39900 acaagagaac agcagacact ggggcctact caagggtaga gggagggaag agaatgagga 39960 ttttaaaact acctattaga tactatgctt attacctgag tggcaaaata atctgtacac 40020 catacccctc tgacatgcca tttgcctata taacaaacct gcatagtact cctgaactta 40080 aaagttaaaa gaaaaaacga aagattaatg agtgtgatac tggaacaata ttatgatgca 40140 ggacaatttt ttgtgtgttt gctagctggg cttgagattt gataagtaag tccgattatc 40200 ctaatccact agtgatgatg ttctaggctt tgaaattcaa actactacta ctccactttg 40260 agagagactg catgagaatt ggacccagcc tggggcttta gacaccatag ttcaaatctt 40320 ggctcttatc attttttagt cacgtgttgt gcactgaatg tttgtgtttc ccagctcccc 40380 aaattcatag gttgaagccc taacctccaa tgtggctgaa tttgagatta gggcctgtga 40440 ggagctggta aaagttaaat gaagtcttaa ggataggtcg ccaatcctat agagttggtg 40500 ctcttacaag aagaggaaga gacaccagag tcctctctct ttgctatatg aggacatggt 40560 gagaagtggc catctgcaag ctcagaagag agccctcacc aggaacttaa gtgtctggca 40620 ccttgatctt ggacttccca acctccagaa ctgtgagaaa taatttttcg ttgtttaaat 40680 cacccaaact gtagtatttt gttatggcag cccaagccaa ctaatatacc atgtaagcag 40740 gttacttaaa tttactaaat acgtaagtta cttaaaattt cccatcctgg ttctaacttt 40800 actagctatc acttttacta gctaacacat tacattttct tcaacttgcc acatgctttt 40860 tttgtgagtt ttaaatgaaa ttgtttaagt actttgttta tcatgctgct gacctatagt 40920 aggcacttaa agttagtttc caggaagttt ggaatggatc ttacttattt atgcaaatgg 40980 ttgactctga tggtacttgt tcctctctgg aaagggttca actctcatta gaatagtcct 41040 atgactgcag taattttgta tgttaaactt atatttttat ctgcagaatg ttaaatctgc 41100 aaacaccatc catcaaccca aaagcaaaaa ggagtgtttc ctaatagtta atagttggta 41160 ggttaatagg aaatctagaa aaaaaaagtt taataatgaa ggctatatta atacccagtc 41220 tcatttgagt gcctgtcagt aaggaaatag ttatctttca ttgttaatca atgaagacca 41280 attggcataa ttagggctct ggtgtgtttt cttcaaatgg tcttctagga cctaatttaa 41340 tatcattcga gaggcttaaa gaggatccca tgtttccaaa tgtatcttag agtcctcagc 41400 tgcccaacat cccaccatta atcatgcttt gcagatgaaa aattgaaggc tccttgtctc 41460 tgaatatctg ggatatgctt ttattcctag gatgaacttc tccttctttg ccaataagga 41520 agaaaaaggg actgaggtga tttataagag cagttctagt gagtgaaata tgggtcctag 41580 caaaggagga cacagctgcc ccttgtaata gtggagggaa ggaaggaggc aggctggcag 41640 tactttgccc tcctcaaccc caaaccctat ctgtttacca cagtggacct tttttctgaa 41700 ctctgacctc attatttcat tcattatcca cataatattc atcaatgttc tccaaggctt 41760 ttagaataaa tctttaacgt ttctccaaaa gtcacaaggt ctgacacctg ccttccattt 41820 tccagcttca tatcataatc ctcctttttg gcagtggcca cactgatcat cttccaggtc 41880 cacaaactca gcatttgctc attgtgaacc ccttacatca tgactgtcag cccaattgtc 41940 atttccttgg ggaggccttc cctgaaccct gggagtggat catattcccc tatcatgtgc 42000 tttcatagca ccatgaatgt ctccttggtg gcagtcccca gcaggagaat tctgtgttta 42060 tctgtatgac tgtttcataa atgtttgtct tcctcccaat agtctgtcag cactttggga 42120 gccagttgtg ttttgctctt gattctacct ccagcacagg atgtctctta gtatttatgg 42180 aaggggacat gaaaaaagaa aaagtccact gcatgaagat ttaatccagt gagactgagg 42240 cctgaacatc tagctttagg gaagccagct gctagcagga cagactggta ggcactaggt 42300 gaggagaatg gaaaaacaca gggaaagagc atcattttct ttattatttt gcctctgaca 42360 gacccctcca agtaacagat tccaaagaga ttgtgaacat tctccctctg gtatggagtc 42420 tcctgtcctg tcagaaatat ggtacccaga ggccaaagct gctgcataag caagttgtca 42480 tgaaactatt ccaggacagg tttcagaagt agggtcttaa aaatgagtat taaatctaat 42540 gttcacccag atacatttcc aacccacata tagacaccga atttagcaat gaaaatggat 42600 gctactctgt taaggattta tttgaaatgt tggttttctc tcgtccatct gatacagatc 42660 atagctctgt ttctgtcatt agattgattt tcatgtttct caacacagac tctcagagat 42720 aagtttaatt tttcagcatg gccataggaa tgatgaagtc attcctcatt aagatgaagt 42780 taagcaaaat ttaataatac ttgtttagga ttccttattt acttttctac acaaaaagag 42840 ttgcaagggg aaaacaaaaa ctttaggttt gagtaacttc cttaattcaa atatagattt 42900 aaaccacttt gtcataatat gcaaatgaac tattgctttt ttccccacag gtctgttttc 42960 aaatagataa tgagattata taaataatta ccttatataa acttaaggtt actcattatt 43020 gaaagcaatc ttcttttttt gtttctggtt tattatggtt taagagtgag tctttgtttt 43080 agatacttga aaacaaagtg tgtgtgtgcg tgtgcatgtg tatgtgtgtg gatatataca 43140 tctagggagg tcgtcaaatt caaaaattat aatacaatgt tgtaatgtca gcacttccta 43200 ttgcatagtt ttataatggg gatatatagc tatgcattaa aatgcattac tgaaatggaa 43260 aatcaggatg tgttaaaaat gaattagtaa ttatattaag atctgaatgg gaactagcat 43320 acaatctaac ttaagttttt gaaaaataaa aaaatccaga aaataattaa tgataagtta 43380 gtttcagtat tacactgata aatatttcaa gaataagcta taaaaaatga ggtagattta 43440 ttattttaag gttcatacta aaagattata atatttattt aactttattt aatttagaat 43500 aagattactg tcatctctct aagcatttat gtaataatgt attatttact tttccattaa 43560 atattactga gataaataag gagtcgtggt gaatgaaata taatttaata agcagggttt 43620 tcttaggtga aaactagtca tgtcctgcta taaatgtata ttgagagaga agctgaatag 43680 accagctcca tgatttagtc aatgacatga cttcagggaa aatgttttta tgccttattg 43740 gccatatctt ttaatacttg cattgaaaat aaaattacat cccaagatta tgagggttgt 43800 gaaattttat aattagatat ttaagtccta aattgattag cagcagtata aacatagaaa 43860 tggattttgg gttaaatctg agaactattt tcttatgcta aaatttgcat gcagatgaca 43920 ataggaaaat caaatgtttt cctggaaaat tttcaaatgg gacaaatagt cgtctttctg 43980 gaaatatgaa ataaagggag tggtagtggt tggactataa acctttttga aggcctttta 44040 atctttagct gtaattcatg ttttatcatc attgaatttt aaaaacagaa aataccttag 44100 aaataattta gtgttaccct gttgatacta ccaaaaaaaa aaaaaaaaaa aaaaaaacag 44160 tgctcagagt cacataactt gattcagtca gagctggtgc tagatgctta gtcttctgac 44220 ttctaattca gtttgctttc attatctact acctgctgct gactcagagc tcctcagcta 44280 tctgcaagtg gatgtgttta ttgagcattt acgatgtaca tgtactactc tcaatgcgaa 44340 ggatgtaatg gtgaatggga gcttactttc tgactcaaat attagttttc tctctttgtg 44400 ttccaaatga aagtgtcctt ttgctttatc tgaagcagga agttgtaagt ttgcttattt 44460 tacttttgaa attttagaga attggcagtg gggtcatgcc atcagaaaca catacatgca 44520 atgcatggat gcactgtgtg aatgagctct ctggaaggtg gtagattatg ggaaagaagg 44580 aagctcagaa agagagtgaa ccaagtcaag aggaaagaga gaagaaacag gcaagtgtgg 44640 agcagaggaa aagtaggagg gtcatgaatc cattctgcag gtgtgtgctg agagactgga 44700 agaaggaaaa gaaccaagga agtctctgcc atgttatctt agttttgtta agggtataaa 44760 gagattgaag agggtttaac taggccatcc ttaaccctag gtaatcccta gagtccttag 44820 cagaactaat aatctaaatt acgaatgtct gtgtgtgcac acacacagaa tgcacttgct 44880 aatgtctatc attatgagta tcttctgtct tctccactac aaggaaagga agggaatgtg 44940 accctctttc ctgattagaa gtaactaggg catagtaaca caaatggatg aattaaactg 45000 tttgaaatgg tgcactggaa tatatttatt ttggggtaaa tcatgaagaa atgaaaaagg 45060 aagagattct cttttgagaa aaagtttgtt tcctattgtc aattgagcaa ctctgtgaac 45120 attctaaaga taaagaatga ttattctgta aagtgctggg atttctggtg ctgtgtgaca 45180 aagttcggtt ccttttgtct aagttagtta taataatctt taatgaaaag cagaggggtc 45240 ccctggtttg gaacaagtac ctgagtcaag agttgacaag tggaatagct gggcccagag 45300 gattctgtcg agttgacaaa gccagaacag tacatttgga cagaaagttt gattttctta 45360 tactgaatgt gatgatcttg aagaacagat tttttttttt tttgcatgaa aataaatctt 45420 tattttcagt tattacccac cagtaagaga aagttaggtt aagggtataa agggattgaa 45480 gaggtttcta cttttgcccg gtccttagtt tgaatagcct tccactcatc caaaatcatc 45540 tcttttggac cctcctcttt cacctcttca acttcattct ctttattttc agtgtctgcc 45600 actggatgat gttcttcaca ttcaagtgtt tcctcagtca catttgattg atccaagtca 45660 ctgcaattac aagatatttg tttctgaatg tatttggggg actctgttaa ttcatctttg 45720 acaattcccc aattgtgaga tccgctacct ccatgttaca ggtccttgtg cttcaggcca 45780 ctgtaatgtg aaaaacaaga tctatcactt ccactatacc tatcaaattc atgtttgccg 45840 tgagaatcaa atccatctcc ttgacccatt gcacgtccac tgccctctca acctcttcca 45900 agaccaccac gacctcaaat aggtcagtca ataattggtc tatcaactga aaattcacct 45960 ccttcaacct tttcttcaag tggcttttca aatctttgtt cacaaggtgg tctcctttct 46020 ggtcttctat caattatttt cccttcaccc tgaagttgtt gatcaggtct tcttccaact 46080 tgtcttattc cttcttcttt ttttcttttt tttttctttt tcctctaggc aagctttatt 46140 cttcgattcc tctatccagg aagggggctg ttggttgcat tttacccaaa tggaatgtga 46200 tgggaattgg gagcttgagt tgtttggaga aggagttgtc aatcctagca aatgtctata 46260 gctggtgtgt ggtgtccatc aattcttgag ggcttggcca tgcagactag ggaatggtca 46320 gaacagagtc attcagaggt ctccagagct ttacaatatc aaggttcagg gggtatagac 46380 agtaaggaaa aaggccattt cctatttctg tccatttttg gtacagtaga cagttaaggt 46440 tttttctttt gactagcttt taaaaaatta cttaggaaat ggaaagctta taaacattca 46500 taagtgaatt gttgaattgt aaccccaagt ggtttcctta cctagtcacc acttaaccag 46560 aaatattaga atacacggtt caacctgaat tcaaccaggg ggataacctg cctgttgctc 46620 aagcagtcat cagagttttt aaaaacaaaa ttaagcaaaa aagacctttc cccaaataca 46680 atcattacta cttagctttg tatgatccat tcctaagaaa gtcacattcc atttcagaaa 46740 acatgactgc ttaaggttca gttaaagtcc ttgccttcag gtgcttactt ttagttttct 46800 ttaaattaac ttctgaaatg tttatcttat gttttgtgct gcattcctga aaactgtaac 46860 ctttaaggac gtaggcctca tctttataaa ggaggaagaa aacaacaagg aggtgtctca 46920 tttgggaggc ggaaggttat gaccaatgct ggaagtcttc ctcttcctta cttgttattc 46980 aacaagatgg gttctgtggt gtcgcatgag gtatgagttg gaaatgaaag ctacaccaca 47040 cttcttacat tcatagggct tctccccagt gtgggtgttc tggtgcacgg tgaggctcaa 47100 cttctgtctg aaggccttcc cacactcatt acacgtgtaa ggtttttctc cattatggat 47160 tctctgttga ataagtaggt atgagctaca tgtgaaggcc ttcccacatt cattacacac 47220 aaaaggaaga tctccactgt gaattctctg gtggacaaaa aggcaagaga gctgactgaa 47280 ggttttccca cattcgctgc agtcataaga tttctgtgca gtgtgaattc tctggtgcat 47340 aataaggtgt gaaaaataac taaaggtttt cccatactct tttcactcat atggcttctc 47400 accagtatgg cttcactgat gtacaataag atttgcactc tcggtaaatg ctttgccaca 47460 atcgttacag gcagagggct tctccccagt gtggatcctc tggtggacaa tatggtttga 47520 gctcccagta aatattttcc aacactcatt acatttacag cattttctgt aatgtggact 47580 ttctggtgcc aagcaagttg tgagctataa ctaaaggttt atagttaaac ctttcactgc 47640 acttaagggt tttttctaag gagtggattt tttgatgtat ggtcagattt gaactctgag 47700 tgaaggcttt cccacatttt gagcaaatat aaggtttctg tccagtgtgg attctctgat 47760 gcacatcgag gtttgcactg tgaatgaagg ccttcccaca ctcatgacat tcaaaaggtt 47820 tctccccagt gtggattctc tgatgcacaa tgaggtttgc actctgacta aatcctttcc 47880 cacatgcact acaatgtaaa agactttcac ccaggctggg tttttggatt tttaacagtg 47940 tcagaattaa gggtgtattt tcccccagat ttcttacatt tctgatcttc ctcttctttg 48000 aaactttcag gtaagtgaca gtcattcact atcacttatc tgaaatcttt catttcactc 48060 cttattctct gcctctttaa catgttttct ttttcacaag cttgtcttaa ctcaggtcct 48120 taagaatcag ctttctggat tttccgaata tgatgagggg attttcagct tcctcacata 48180 tttcagtttt tggaaccagt aactgaaggt tcttggtttc agcacccttt cttcctcttc 48240 tgattcacca gtctgacgac cctcccctgg gatctagact tccatgtttt cagagtgcac 48300 ttgttggctg ggtacctgac ctgggaagtt ttcttcttcc tcctcctcct ttttcacctt 48360 caatgggccc cgtagggcta gggccatggc ttctctcaat tctgcagtca tctctgctta 48420 gcaggggaac gcctatagct gggagctgcc cagcagaggt caaaccccat ctaagcttta 48480 tgtttcaaaa gcttcttctt gagtttcttc ccagggccaa gatgagtact gcctatgtgg 48540 gcagctgaga ggcgcgacct gagttcactg gctctgcagc aggaggctga gggaccggga 48600 cctcagcgcc tactggcacg agaacgatga cccatattcc ttctttctta agcgccagag 48660 gcggctgcat ctcctctttc ttgtcaaccg cgccacgctg gggtggcaac ggattcttgc 48720 ggtctttctg gggctccttg cgcagctagc tatttgcctg cccccttgga gttggtctgg 48780 gccgcagcct gagctgccgt tcttggcccc agggccccca atgccgcccc tgccagcttg 48840 ctttttcttg ttctccgctg ccttcagcac ctcgaagggg tccgattcgt tgtcaaataa 48900 ctggtccaat cggttgatga ccgcgcaact gaagccttcc tgtaagtgcc caggcatgat 48960 gattgctcgg cggcacattc ctccacggat tgcagcgggc tgcgcggagc caagagcgcc 49020 tgcttcagct catcccacaa gatcaaagag caaattttta aaaatttgcc agtaaatgtc 49080 aggcaaggta aatttcaaaa tgaattttta acgtctctaa aatggagtta tgtttgatta 49140 tgagtttatg acgaattaaa agatagttct agatattatt ctagaaagct tcttgttctg 49200 ggaaagagag agagtttgga aacttgagat aagaccttta ttgtctattt tattatttac 49260 tgctaacaaa ctgcattttc tcactgttca ttggaatagg tgggttcagg gaacttaaga 49320 aagcctaatg ggaagtggga aaagtaaatt atttcgtata tttttatgtg tacaaacagt 49380 tgataaagga ggaagtgtag tggtggggtg gatcatgcat attgggatag aagagatagt 49440 ataattatta acaattatac tggacatttt ggattaagtc ctccaaattt tcttatttgt 49500 gagggtacaa gtcactattt acactatggt aagctgcatg caaatatctg agtacctttc 49560 tgttcctacc ttcagctggg ccagcactaa gctgaaatag cctatactta gatgtttttc 49620 tgaggaagta cgtttttcct tttccctcag attcctggtg cctggtatag cacttttttg 49680 atttgctctt gttctggcaa taggtcaact ggctctcatg gtccttaaca tttcaggtaa 49740 ataattccaa cagttgtgac tggaaggaat ccaaatcaac tcaaggcatc cactctatgt 49800 tcaaaatgcc atgttttgag tgatttgtcc tttggttagt aactttcaaa aatatgagga 49860 ctggaaggaa aagatactat ttgaggaact aatggaaaag caagcagttt ttgatacact 49920 aagatattcc cttatgatac aaggagtgtg atcattgact ttcctactta cctaaacatt 49980 atgctgtcag agcatgtgga taggcctagt ggttaacaca catagaaaat tcagactgcc 50040 tagttcaatt cccagcttca tcatttgcta gctatataat ctttagtaaa ttagttaact 50100 ttcctgtgcc tcagtctggt tttcctgaag attaaatgaa tttatatttc ttaagtgcct 50160 agaactgtag ctgatctgta acaagtactg tatgtttttg tttaaataat aaataaaatg 50220 accggattgt tcagatggaa aaacaggggt cttaggcggc ttaggatttt ctgtaaagta 50280 acagaatcat ttgatggcag aaacaacgat attatcactg tccagaaccc taatggagaa 50340 ctatagctct taagggtgat gtggggagaa atacactgat gaaagacaat caacattatt 50400 agacaagatg ggagagagtg ggaactagtc attcatttat ctaatggctt agtcagcaag 50460 taactattta atgcctactt tgggccttga cactatacca acattgtgca ggaagtgatt 50520 aaaattcata agaacattca cttaggctgg gataaacaag aggtcttttg caaaatctga 50580 tgatgagctt tttgatgttg agttgacaaa ctctgcagca ggtcagtggt ggggggaaat 50640 tatcataaaa ttccatccct taaacatcta caggaagatg attattttaa gatgctttac 50700 ttctggagat gtatgcttta cttcctctta gagaatctgg cttatgttct catgttctgg 50760 ttttatatgt aattggtcat gagcttaatt tgatccaagc atttggcaca gttaccccca 50820 gaagttaact catttgtgga ctgtataaac gctattgcac aaaaaagaag tatatatata 50880 caaatagtca taatagacca catctcggtt aatagcttta agtctagatg aaatgtttta 50940 agaaggatat tgacaaatta gagaacatta gaagcatttg ccagaatagt gacatggcaa 51000 gaaattatgc caaatagtag aaagagaatt agacgcctaa gtggaacatg gtatataacc 51060 cataagaatt tgagggattg tcattggtag aataagatgt tattcttggc tgcttccagc 51120 tgaggagtgg tggatgggtg actaaggcct ataagagagc aaatataagg aagagtttct 51180 aaatgctaaa gtcaatttcc aaagaaacag cctggcctct aagggaaaga gcttcttgtc 51240 agtagatgtg tttaggtggg gccagctgaa caagctcctg agctctgggg attagactcc 51300 atctgctgga taggaggtac aactaagtcg tctcagaggt tccctgtgtt ccaagattct 51360 gttactctgt gatttcatga ctttgatgtc acctccctta ggttggttac gctaaataat 51420 gttaaaagtc agtgtatgcc ttaagattgg gtgaattgct atgacgcaat gatttttacc 51480 agataagcgg ctgagtctaa gaatgaaact actgtttcta agtgaaagag gtatgaaaac 51540 ctaaagataa tatttttctc tgtagataga aagaatttgt attataggtc tgtgttggaa 51600 gtatagcagg gcatcaccag aattcaccct aactgggtga attcacggca gtaatcagtg 51660 gaatgtgtag tttgacaatg aggccttatc atttctaagt agtttctttt tttttctttc 51720 tttctttttg agacagagtc tcacactgtt gcccagagct ttgccctgga actcttggag 51780 tccaatggcg tgatctcgtg tccctgcagc ctctgtctcc caggttcaaa tgaaactctt 51840 gactcagatt cccgatttct aagtggagag ttatgaatgg cccaaagata atatttttct 51900 ctatagatag aaataatttg tatctacgtc tgtgttggat atatagcagg gcattaccag 51960 aattcaacct aactcggtga attcatggca gtgaacactg caatatgtgg tttaataatg 52020 aggccttatt cttaaggcaa agctcagaaa agctgataag caaattagaa aggtctattg 52080 aaaagtgtct gtctggccgg gtgtggtggc tcatgcctgt aatcctagca ctttgggagc 52140 ccaagttggg tggatcactt gaggtctgga gttcaaaacc agcttggcca acatggcaaa 52200 accccatctc tactaaaaat acaaaaaatt aacagggcgt ggtggtgcac acctgtaatc 52260 ccagctactt gggaggctga ggcaggagaa tcgcttgaac ccgggaagca gaggttgtag 52320 tgagccaaga tcgtgccgca gcactccagc ctgggcgaca gaacaagact cagtctccca 52380 aaaaaacaaa caggcaacag aacaagactg agtctctcaa acaaacaaaa caaaacaaaa 52440 aaacaaaaaa aagaagagtg tctgtctgcc aacctgcttc cacgaaggcc cttcttctga 52500 ttgtagaagt gcctggttta ggatggcagt gtgctctacc tgctgtctgg tgagtagtca 52560 ggattggact tctgtaagac actctgtatg agaggcttgc caataccttc agaatcaggc 52620 agaggtcttt ggcgagttat ttctgaatga agcatatctg cgtgtctgtc tgatctaagc 52680 ctgggaacca cgagggaaga tactgtttaa gcaacaacag caaaaaaaag gcagggaact 52740 taagagagac atggatttta gtcactaaga acatgaagag gaacattttg ataatatgta 52800 ctctatttta taaaacctgt agctatagga acatatattt gcctacaata tatttttttt 52860 cttttttcac ccttgatttt taactatttt ctacaacagt ttttcttttt tttttttttt 52920 ttgcccttga tattttttct tttcttttct tttttttttt ttttttgaga cagagtcttg 52980 ctctgtcacc caggctggag tgcagtggtg cgatctcagc tcattgcaac tccctcctcc 53040 tgggtttaag tgattctcct gcctcagcct cctgagtagt agcttggatt ataggcaccc 53100 gccaccacac ctggctaatt tttgtatttg tagtagagac ggggtttcac catgttggcc 53160 aggctggtct ggaactcctg acctcaagtg atctgcccac ctcagcctcc caaagttctg 53220 agattacagg catgagccac tgtgcctggc ctgcctttga tttttaacta ttcctcatgt 53280 gaaaatttaa gtctttctat gggttaaagg gaaccggtaa agagcattgg atttatgctt 53340 gagctggaat ttccctctag gtttggatat agtgaaggca gtggagattt gggtttataa 53400 cagacgcaga tttgtgaagc tataaaatct gaagcctcaa ggcccctcac ttgcagagac 53460 tccttccagg gtcctggaag ggaccctact aatgtgttat tatggtcatt attttataaa 53520 aattgtaaaa cgtaatgtgt ttcagccatg atttgttaaa attattgtct tcttccaatt 53580 caactttccc tcctttgtcc ttccctttcc agttgggtgg cattaaagtg gccatgcacg 53640 ttttgtattt gtaattgtgc atttttttgt cttaaaaagg acccccaacc aaattgtata 53700 agtttcaggc cctgaaaaca tgggtcttcc actgggtata ggaatgaaat aagtaacaat 53760 ctggaaattg cctgtgtagc agaatcagcc aaaagtcaga gtcagcaatc aaaatgttgt 53820 gacgtggtga gtgagagtaa attcgaatcc gtaatcccaa cagcatttga cagtgggaaa 53880 atggggcttt tttctcccct ctttagggtt cattttaaag aagaattcca tgcaaagggt 53940 gtcatgaatt gagaaatata catcagatta tatatataat atatattttt tgtttgtttg 54000 tttgttttga gacggaatct cgctctgtca cctaggctgg agtacagtgg tgcgatctcg 54060 gctcactgca agctctgcct cctgggttca cgccattctc ctgcctcagc ctccctagta 54120 gctgggacta caggcgcccg ccacctagcc cggctagttt tttgtatttt ttagtagaga 54180 cggggtttca cagtgttagc caggatgatc tggatctcct gacctcgtga tccgcccacc 54240 tcagcctccc aaagtgctgg gattacaggt gtgacacacc atgcctggct tttttttttt 54300 tttttttttt tttgagatgg agtccctctc agtcgcccag gctggagtgc agtggcgcga 54360 tctcagctta ctgcgatctc aactcactgc aacctctgct ccagggttca agtgatttcc 54420 ctgcctcagc ttcccaggta gctgggatta caggttggtg ccaccatgcc tggctaattt 54480 tttatatttt agtagagaca gggtttcacc attttgacca ggatggtctc catctcctga 54540 ccttgtgatc tgcctgtctt ggccttccaa agtgctggga tggcaggtgt gagccactgc 54600 acctggccta acttattttt aaaaatagca aattctttaa aataatgcaa attggtgatg 54660 aattatgaaa atcatgatga gaaactccta actgaagaga gaaattgttt gaaaactgta 54720 ttctcctttt cctctactac tttatgtaat tataaagcct ttctctaaag ttcctttctg 54780 acagagaaat actggccaac agaaattcaa cggaaatttg agatttttga cattcaggca 54840 atttatatgg tgtttcaggt gttactacct ctaatagtct atcaataaaa ccctgatagg 54900 ggatggtctc tcttttttgc cttctactcc atctcttctc gcacaccctt gtgattgttg 54960 ctagcattca cacttactct ctctttattt atttattttt tgagacaggg tctcactttg 55020 tcacccaggc tgtagtgcag tggcgcgatc tcagctcact gcagcctcca cctctggagc 55080 tcaagggatt cgagtagcta ggactacagg cgtgtatcac cacccctggc taatttttgt 55140 attttttgta gagctggggt tttgacatgt tgcccaggct ggtctccaac acctgggatc 55200 aagcagtctg cccaccttgg cctcccaaag tgctgaaatt acaggtatga gcctccattg 55260 ctgggcactt actctctttt taattatcag cttgcaaatg agaaatctgc ccaaggagcc 55320 tgagcttggt gcatacaagt tcatttcagc cccatcggtg agtttatgat tctatgagac 55380 attaaagata tattttattt ggacatgtta aaaaaaaaac tgtatgtttc ttcacaacat 55440 ccaaagtaat tattttattg gtgttgataa ttattattga ggaatagggt aatcatgcgt 55500 gttatcaacc atttcctaaa tggtacctag ttaacatgtt aggggaggga atctaatctg 55560 aaagtgatgc ccatttagtg aagccaagtg atgtagcaag agttgagaac aacttataaa 55620 gggacctctt agcccatgtc cagaacattg tcattaacat aaagataggc tgccaaggga 55680 aaggacaact gtatggtcag tttacccaga tctgaactct caaaaatcaa gcactctcat 55740 tctgttaggg tgatgtcaga gaaaataacc ttcacaaggt ttgaaaacac agttgtaaca 55800 tactgggcta tgttccaggg ctagcattgg ctcagatttt tatcttgtgc ttagaaccag 55860 cctactgttg tctctgcaga gagaacacta agtaggtact taataatact ttgctggcca 55920 gcacatagct ctgtgcagaa cgaacactaa gtaggtactt aataatgctt gcaggccagc 55980 acatggatgg atcatgttta taagtgtgta tcgtaaacac tttgccttca ggaaattgtt 56040 tcctttttag agttttcata ctgtggacat ccttaaaaat cccagaaaat gtatctttat 56100 ggattgacat gtgactccta catgttaagt tagaatccaa tgaaatgctg ttctttgggc 56160 taaactttca agactcatgt gtgtggtgta taattcatta actaaagata tgattcatac 56220 tttaccttat gtaggaccac aggtatccac atatccacca ttaggatatt cttcaaatct 56280 catagtttgg aagattttca gacattgtaa acagtaaatg catcagaaat aagcattttc 56340 cagaagaggg aggtatgaaa tagtgattga tcagcctgtt gcttagtcct ggaaatgtga 56400 aatcagatca atacgaaaaa gatgctttcc ttgcattctc ttccagaaat atgcagcctg 56460 ctgctctttt gtcttcagtg taatcatgct gcagtgagga gagcccagaa ctgtttttaa 56520 attcaaaagg acaattgctt tctgctcact caggtccact gaggcatgct ccaagacagg 56580 aaaaaggtgc ttagcaggat ctctttgcta gagattcaat atgtgaattt tactttgaga 56640 ataaaaagtt cacccacttt taaaaggtta atcaaaagca cattgtagtg tattcttcct 56700 ttcctatgca atttcctatg gaatctattt aaattctggc tgcagagcag caatattttt 56760 caaagaggca gtccttctgc caagtggctc tagaagtacc cataatctcc atgtcagaag 56820 tatggaaaat gaaagagatg aacacttcct tcagaaattg tacctttgat tcctttactt 56880 tacagccagg caggaagaat cctgagagag gcctttaccg aaagttcaat atttatgagc 56940 tacatactga caaatgaaaa atgattccta gccctgagtt gcttacccta tcaagtttgc 57000 ccattatttt caggctgttg agcattgttt gaaaaatcga tctgggagct acctgagtct 57060 atccattacc atggtcttgc tgttataaat tcacactggg ttatttctat tccctaagtt 57120 tgctctgccc tttcctaccc tttaccttta tggtcttcca tctggtaaat tttctctcac 57180 ccttcctggt ctagctgtcc ttcgtcttca cttatgaagg cttccttgtt ttcctttttc 57240 agaattaatt gctaatttct cactgctctc taagcattaa tacacccatc atagccttca 57300 tcataatatg ctttgtactg tagttattta tgtacttatt tgtttttccc cttctttgtt 57360 cttcagttaa atgcatgcca gatccaactt tacagatggg aaaaatgagc tctgaagttt 57420 aataacttgc ccaaggctac ccagttagaa gagttatgga cttcactctg aatatggtga 57480 cttttgttct cgtgtgttgc cttctttagt cttcttaaga aaaaccttgt cttgttttct 57540 tttctcctta ggttgactta ttctatacat tagaagtttc taaattataa tcaaactggc 57600 attccaaggt catagccata tgtaaatcag aatgcagttt tacatagatt cattattact 57660 gtgcgtggag attagaagcc agctcacaag aagacttaat ttggaaagat aaggtaacca 57720 actttacatg agtgctagcc tttcattgat ttctcacctc cattctatat tcctcctggc 57780 acttgtttta aatctgttct actgaagtcc atactctacc cccttgctct cagccgatga 57840 tctgtttacc tgctctgaga agatttagat cagtagttct caaactttaa tatgtataaa 57900 aatcacatgc agagctcttt ctaacatagt ttcctgggcc ttttcccagg aattctgatt 57960 cagtaggtca gggtggggct catgagtgct ccgttctaac aagctcccag gtgatggcaa 58020 cacagctggt ctgaggacta cactttgaga acctctgatt taggccatcc tctgagatag 58080 gatgtcttct tccatacgtc ttctctggat gtttatcctt cctctccttc tgtgagtgag 58140 aattcagtca ttctattctc aggctgaacc ctctcaccac aagcttttat cccatctcac 58200 ttcatctatt tcaggacctt gcttccactt gtctctcttt gcatctttta tgtcaccctc 58260 tcaattgcct tttattctcc cctgctttac taataaaact gttcctttct cagttgtact 58320 gttttagata catctaatga ttgtaagcaa aattattttc tataagaatg cttgacaatt 58380 tcagattcaa ctcagttggc taggaactaa gtttctgtaa tttgggaatt gacttgtaga 58440 gagcaaaatt aagaaaccaa gtttaacttt ttttaatgga tgtgagtgga agagactaat 58500 gagatactac aaaagagtta acttcttaca tttctgtagt ctaatacgag atagtttctc 58560 caggaattaa catagcacat ctggttcact gacctgagtt tgtttcctgg tgaggctttg 58620 cagtatcatc catatctcag gcaaaggtat tccagcattt tgtagttaag cagttggagg 58680 aggagtaggg agaacttgtg tactttgaaa catttcacaa tgaactactt tgcattctaa 58740 tgatgttctc cttacttaag gactttgcta tgtaaagatg ctttgtcctt ctgataatca 58800 cttacacttt tcttctgtgt tcatatcact tcattaatcc tggttacttg taatgaatca 58860 taatcttacc cacttattct tgtgtgactc attcctactt gtattctttt ttttttttta 58920 atttatttat tattattata ctttaagttg tagggtacat gtgcataacg tgcaggtttg 58980 ttacatatgt atacttgtgc catgttggta atagttgtct gtgtctgata acacattgtc 59040 aattgactat gctattttta atgtaagcct tggcaaaaag gtttacttag agaaaagctg 59100 tacatttaat tcccccatgc ctcagttccc aaatttacta ataaagatta tacttagctg 59160 tcactccaca tttcatcagt agaattaaaa tgaatagaga ttatgaaata agacaacaaa 59220 aaagatataa ttataatgga ccagaatgag aaatcactac agatcaatgc aaatgacctg 59280 ccatgtcaga ttcctagatg cagtttcttt agtcagtggg ccatatttct tcctcattct 59340 ttgtttttcc atcatgcctt ccaaaactaa attttaacca agaaggaaat atcatttgtc 59400 ttctgatata ggaagatcct actgagagat tatattcgta tatttcatcc atcggcctat 59460 aggtggaatt gtatttaaaa tactaataaa ggttattatt gcttatatct ctaaaaatgc 59520 tccaactctc caaataaggc ttatattgtt gatgatattt atcagtggct ctgaacactt 59580 gcatatcata aaactctccc tcaaaattta accttaaact ctttcaggct tgtcttcatc 59640 acagtgggaa ctgaggacag ctgctcatgt tttttgatag aacagctctt aacatgcttt 59700 tgctcttgcc tcccactgcc caacaccagc tgcgtacaca cactccactt gctgtgtgca 59760 tgctctggct cctggctcct tttccttcag ctaagttagc ctggttttat ttggtttcat 59820 catacgaagt atctattagt aaaactttta tgaactctga ttatagtact aaactcacaa 59880 taaagtaatc agaacttcat ttattaaaac actgggctga gcttattttt taatttagta 59940 tgcatgacaa ttttgtaagg taggaatttt cattcccctt ttatagatgg gaaaactgag 60000 gtccagggtg taggtaacat tttcaaagtt aactcagaag taaatggctt agctgtaatt 60060 tgaacccagg ttcctacaat tctaaagccc acccttttaa ctgctgtgca cacaattact 60120 gtgttcttac ttgctctctg aaatacaaca ccttattctc atttcatctg ctctttctgc 60180 cctatacact tcggtttctg ctctgtagat acctgctgtg gattgtgaca tctcaatttt 60240 ttttgtacct tggcagggtt ttgattgatg tattggtgtt ccgaactctt tagcatatat 60300 attaatatgg aagacctacc aaatatttca tctaataggg attattttgt ctacctattt 60360 catctttctt tataatgtaa gtttgtagaa ggaagaaact ataaattgct caattaggga 60420 ctccacagtg agccaagcgc atacatactt gacccagaga agtcatcgcc atctttatca 60480 ccacagctaa catatgggta gtgctcacca tctaccaaat atgtgcatgg attattttat 60540 ttactcttta cagtaacccc ataaagtaga ttatgttgcc atcccaaggt taaaaaacta 60600 gtccacgttc atcgagttac tgcatgatag agttcgagcc taaccaacac caatctatcc 60660 acgcatctgt ccacacagtt aactactcca cacttctcag tggaatctac agttccatgt 60720 atttcgtatt ccttccattt ttcactatct gtcctcttcg ccatcttagc ctgtttctct 60780 ccttttcact ttctgcccta tgcatacctg ctcaatcttc agtcttctct gccttacctt 60840 ctctttctca attttgttct cgttctgtcc tatcctgcct ccccactctt cttatctcat 60900 tttcctagtc cccttgtcac ctttttacct cttacatatt tctttttaaa aagtaacttc 60960 aagcttgata atagattctt caactctctt agcaatatct tatcctaacc ataataaaat 61020 gataaagtgc taggtgtaaa cagaagtaga atatgaaatt gaagtgaaga atctctttac 61080 tttttctgtt agaaacgtaa ataatgagtg actataacat cttggtctcc ataacttcta 61140 agtgttaaat aaaacacatt tctctttttt tatttaacac acacacatcc acacacacat 61200 aaacttgttt tatgcattga ttgccattta ttgagcagca taattttgga aatgcaatag 61260 ctacaaaaca atttttaagt tattatcata cagtgacatt aataggctca tcactttgct 61320 ttctttcctt tgttctatca tgtagagagt tgctttagag atcattgtgt attgatatga 61380 attatcgttg aagttttatt agtctggatg tctggttttg ggcattttga taaatttctt 61440 ttgctccaaa tccagaagtt atggccattc agctttataa ataagacttt tttaaaaagg 61500 caaagtcata aaataaatat ttcaaagcag tgttagatat agccagctga ataaactgcc 61560 ctttctattt aactttgaac tctaaacctc atttaaatat cctccctttt ttctctaaag 61620 aaggcaagaa aaaaaaaaaa caattacagt agattctaaa ataaaatata gcaagaacat 61680 ttttgtaaga gatacctcag atagaaggct gtaataattg ggcaagtatt tgcacctaac 61740 cagtagaact tagaagagaa aacgtgaaat gaacttctta gcttatggaa tggtgtggat 61800 aggtttgcat tacttagatg tttacagagc tctagcattt acttactgaa acactggaat 61860 ggttcatatc cctgtggttt ctacctcatt tcttccagaa ggattaggtt gtatgctgcc 61920 agagaccaca ctgactctta gtaatgggat caccaaattc tggttcacaa ttttgtgcat 61980 agagagattg cactaatatc tcaaaattgt agctctgatt ataaccctgg tatagaaatc 62040 tgagctatgt tggcagtgcc atgctgtaca gtcgaatcca cctgattata tctgcatttg 62100 tgacagctgg gctggccttc attggcatat gcctctttgc tgtgcccagg gctttgaatg 62160 caaaatgaaa gatcagcatg atattagggg cccatgatcc atagaggtag cttcccaagt 62220 aaacagtgtc tcagctttaa catggccccc aatatcctgc tttatttttc tggactgaag 62280 ttcctatgac agatttgttg ctttcaaaaa gtaattttgc agatttgtcc ttttttaaaa 62340 gaaataaaat ttgcctccac ttcctactga aagtgatatg gtagtatcca tcttataatt 62400 gcacagattc aaaaataagc cacaaatatg ttagctgaag tataactgtg gactataaaa 62460 tacagatatc atagcctata atatggaggg tagtttgacg ttataaagcc atttttctgt 62520 gttttacatt atcataaaat ttaactactg aagggaaagt gaaggtttta atatttaagt 62580 aagcctagca cttaaagaga aacacacata ttttccttgg aaaaaaggaa gttccatttt 62640 ggacactgca aatgacggtg ccagctgttg tcatagtatt tctagcatcc actgaggatt 62700 aattccaggc ccagcaaatt cactggatga gcagaaacag ccaaagaagt aaacactggt 62760 gcttctgccg tggtattatt aaattacgcg ggagacttct gcaaagttgg atatctagtg 62820 aacgctggat tatcatgcct gagcatcatt cactttgtgg atatctgcag aaaactgaat 62880 cccgaacttg ctttcttctg cctcttggcc ctcttcctct gtagaggtat actcagaaaa 62940 tgtgatctca tttgaatata aacttttcta ttaatattca ttaagtactc atacaatata 63000 agctgaggaa acagtggtgg gtataaaaca ccagcctgat gtaaagagct tactttcact 63060 gtagaggcaa gatagcataa tgaaacagag atgggtttca gaggcaggtg gaccagaatt 63120 caaatcctat ttcttctaag tatggccttg ggcccatcac ttaaatttct gagactcagt 63180 ttccttttct ataaaaggta gatactaacc atgctacaga gttctgttga gaattagaaa 63240 tatttacaga tacttagacc actacaagat agctcttttt ctagaagagg cataccttat 63300 tatatataat ctatgaaaca gaatatggaa gatgctaaat gaaaggtaca atcagagaat 63360 gccccaggcc ctcaagaagg aaggtggaat ggatgaggaa gtctgctgtc caagggatgg 63420 gccggagcta aggcaagata tgtgtgtggg ccttcactaa ctaggcacag ggagagggca 63480 ttccagcagc aggtgtaggt ccggccaagg aattaagaca ggaacgcaag tggcgttttc 63540 caggcagaag attaggaagt tttagatcag cctggataca gagaccttga atagcaagcc 63600 gactgaggaa tgcatggaag aatgactact agctggagta aaacataaac ctcaaggcct 63660 cttttctctt tcacctttcc tcttgcccac atcacggaca gacagttctt gcttttcctt 63720 atactctgtt tctgtgagca attttaagaa ggcagagtgc ataatggtat tacttttatg 63780 tctgcatgtg tattgccaca tgaagcctgt agttttgctt ttcaaactac tagattgtga 63840 ccttgtaatg atctggcaaa aggctgattg aatttataag agcagtaaat taatatagtg 63900 gataatagtg ggaaaaaatt agtggctaat actggggaat gagaagatta ggaaagacat 63960 aaataaaata tgggtggtgt aaataaaact taaagtgaaa atatggggaa gggactgctt 64020 atgattcacc ttacagccat gtagaaattt tgattaacag agcagtgtat ctgaggcatg 64080 ttgtaaagaa tggactgggg tctgttttca ctgtcgattc tttctgcgag tgcatgttca 64140 tgaagatatt ggaggctatt tttctatagg caactggtgg ttttctgctg taggcagaag 64200 tagttgaggt aatcctaggg aggtgacact gaatggggct gtggtcctac tttatgtaag 64260 gttattatac gtgaaagaaa gagtaatttt taaaagtaat taactagtgg tagattatga 64320 actaacacta gcaaaggttg attataaatc agattttctt tttactactg atttggaaac 64380 aatctttgga gaaatagatt tggaatggtt aaatatcact tttgggagca cattttgcta 64440 ccacagctta acggtactct taagagaaag ctttacaaat ggggcaacct tgaaagacac 64500 atttcatatg cattcaaatt caagatatga ccgaaagctc tgttgccagg gtaaaggttt 64560 tgagagttaa atgggaattt ggaaaacaat actcaaaaat tgacttaaaa tgcagatgca 64620 gataagccta caagtattta aagtgtggag acatcaaaga atgtaagaaa tagtttggat 64680 cactaacagg aatgtgtaat gggaagtcaa aatctatgct gtcaggaaaa attcatatta 64740 ttgggtagaa actctattat ttggtacatt taagataaaa tgaaaattgt gttttcaaag 64800 ggttaggcct catagtggat gagtgattgg ggcgttttct ggtttcagtg attctgtagg 64860 cagaaaacag tttttactgc caagtgtgtc agtgaagcgg gggagataga gaccttactg 64920 tgttaagtga aatctgttgc ttaagaataa agctggcatt tctgtagaat ggagaaggaa 64980 tttggtatta tcatatcatc aaaaaaaaaa aaaaactgct ctttgaagag tagatttttt 65040 aaagtctgat tatcagtatt tatttaaaac tactgcctaa gtatttaaac agtttcaggc 65100 tctgatttta tttttgttaa aaaatgaaac ctatgcctaa aaattatttt aagtagttat 65160 atggatagat gagctacaca gtttcagacc tgtgtatatg actttttaag aggtctgtgg 65220 tatccaataa taaatgatct tatgcaggga tttgacacat aatgggtcat gcattatcta 65280 taccttgtta atgggatctg tatagagtga tagcagaaaa gaaagttaat tttaggatcc 65340 tttaatgcct ataaatttag agcaaaagaa gtatttctaa aagctcatct tttgtataca 65400 tatgcccaat cacaagtttt accgacattt ttacacgttt taggcctgaa gtatttgatt 65460 cagctcttat ttgtcaagat acaatatgat tacattagta aaatacaaaa gggcggataa 65520 gtttttcttc ttttgcctat cttatagtca cgctgcaaag cctccatcac acttttttgg 65580 ctgaggtaga tctagatgta tagaggccaa ctaatatagt tttatataat caacataggg 65640 aagtcatttc agagactggc attgagctct tggagggaag aaaatgaatc ttaaagcttc 65700 ttgggaatat ccctcactgc agcagaggtt atgtgctcta atggatgctc cgtaaatgct 65760 tgagagaata taagtcccat aggttagcat gtacttaatt ctacctaaca tggaaacctc 65820 tccatacatt ctatagctga attattttag gagctcaaaa ggagtaacag gaactaaagg 65880 gaacaccagc tccaagattg gatttttagg ctttcttgct agtgtaacac ttcctttcct 65940 attggactat tggcaaccat atcctggcta attggaagtg attttcaggg gaaaggaaga 66000 ggtcataagt tcttgcctcc ctattttcct tcttgttggg ttttagtaac ttaccttaag 66060 acgtagtgtc atcctattca aactcctaat attcagaaac cgactttcat tattcaaaca 66120 tgttgaggaa aaaaatgtct ccttgcatcc tcctctgctt aaaacttctc cagtaccatc 66180 aagcgtggac agatatatga cagtggcagt atccagaaga cacaccatct atgtaacaaa 66240 ccctagaaat aaagtatggt ataatcctaa gcattcactt ggcactgtcg cttctgggaa 66300 tttgctatga gtcagccaca ggcatctctg tgtaccttca agcccagctt agcacatatg 66360 ggaggataag agagaacatg tacttcttga atacatcttc tatagagtaa actaatcctt 66420 agctaagttg atgatatcct cacccagaat ttaaaagttc agtagagact cttcttgaaa 66480 tgttgaattt ttatttctgc ttattgccct ttatagctgg gtgaaatgca gtgaagatat 66540 tcactggtac tataaaaatg cattggttct ttttggtgag ctacttgact atcagagcca 66600 aatacgtagg tagttggaat taaatttcca atttagcatc ccccttagaa gggtgataga 66660 agctccaatg tcttggtgtt tctgtttctg agtatctgct gtctcactga ggcaacatgc 66720 tagcctccat gttgttttat ttcacagaca tagaactaag tgacacatct gccaattccc 66780 cctcccattt tctttgatgg aggtagatta catttggtgt agatattgct tgaaggtact 66840 tgttgttctt tcttacaagt aaacaagaaa gagagcagca aataatagct agaaggaaga 66900 tatgcccaca gcacattcag gccacttagt ctatctagta agtacttaag agtgtttcag 66960 gcatcaagca tgtactggga gacatgcaca cagaaaaagg acaagcaata gattcctttg 67020 agagtgacat ggtaggtctg aagagtgaat gtaacttttt gtctccatcc cctcagtgat 67080 tcattaatta tttattagct atttttttcc accaggatta caatcatttt acatttgctt 67140 gccagcctag tgggttatta atagtggtta ctctatttat ttacacattt tctattgtac 67200 gttattcatc ctttattagt tcacccccac ccctggtcac cattcttttt tctttcgttt 67260 gacctttcat ggctaccgta ttatcaagtg atcaggaaaa aaatgcactg gtgtcagaat 67320 taggccaaca cagacatatg ggatggtagg ttcatttggg ttgggtagag agctgtttga 67380 aacttgtata cacatttttc aatttcaaga gggaacattt acagtaaagg aagcatgata 67440 tccatagtct gcagtggtct aatggaggtg agctcaggaa tctcagatgc atgtagctct 67500 acaagtctcc attatacaaa ttatgttgaa tatttcatct cttgcgacag attagttttg 67560 ggccatcatg aaaaactttc ctgaagatta agtcaaactt atctatgcat gccttctttg 67620 gatacgtaga tccacccttg acagctactc tgtctactaa ttctgtcaag taggactgag 67680 cttttctgaa cacctctcct tttgttaaca agaaggagaa gaagaaaatt aaacactcct 67740 ggcatctgcc tggctgtgat ttagcccttg gtaaagagta ttacaaattg agatggtgcc 67800 agactgctcc tgtgattcat ctcttctcct gtcaagacca gttgaagcga tgcaattgga 67860 aacctctcta gtttgtgaag agacacttta tgttggaagg aacagcataa gcagaatagt 67920 acttaggcct tcaaagcaga gacaattgat ttctctggat tggtgaacaa tcactgcaaa 67980 ttaaggtcaa acgtattatc aactaattca gtgtactagg cttcttcatc atttcccacg 68040 acttgttctc ttttagaaga tggtttagca aattggagca attatttttt aaaaaaatct 68100 tgctgcagag ttagtgataa aacacaagaa agtttaaggc tggatatagc atgtccatct 68160 ttatcaagac gcagatccat agagaggtgt gcttgctctt gggatactgg gtgaaaatcc 68220 aggcactgtg ttgcgggagg ctgatttctg aaagttgggg catcattgtt tggcctgtga 68280 cgtttgtgtc aggtatgtct tgtcccacag aatacttttt atagctgtta aaggacagat 68340 tgtcttcagg acaattggta cccgtgccag agtatggtat attctgaaag aaaatccatt 68400 tactctcatc tgtaatttat ccccttagtt gaaacatgat cccagtgtag gacatttact 68460 tttcacattc catttaaatc agtgtagttt cttcctatct taatgaattt tacctcattt 68520 ctttgtcttg caaaaaccca gggctgaatg gtaaaatttc aaaacaaatc tttcacaagg 68580 ctggaactag acactctgtt gggtcacatg caagttattt gcagaagagg aacactttgc 68640 atgtgaataa gagaaagcaa agcacttaca ccaatactca gtgctcttgg ggccaggagt 68700 gaggggcctt ccatgtttgc aggacatcta tttgggcctt atattctgct acagccccaa 68760 gtccttacct catatctgcc tggtgtccta tttttctgct taaagagtca aagactgaaa 68820 ttcttatcag tgtttcccat tcattcctaa gttactttgg ccttcacgtg gagccaccat 68880 gctgtggccc acaaagtgtg ctattcactt aaacttattt atcttaaact ttttatgaat 68940 tgtggttgca ttctttgact ttctttgctg atcacagttt acattaatcc tgggacattt 69000 gactcttaag cgctacatga tagtactatc taatggtttc caatgttata cgaatgtctc 69060 tctttcccat ttcatccctt tctctctgtt ggttttgact tgaagctctc tggttgtttc 69120 atggcaatga ttattagtga gagtattatc tattaccaag tgtttcttgt tcagttttgc 69180 atagtttcaa tgtcttttta agcaaggatt gccaaactac aagccacctg tttttggaga 69240 tgccatttaa ttggaacact gccataccca ttcatttaca tatcatctat ggctcctttc 69300 tcactacaag ggcattgttt ggtagttaaa acacagacct tatgtacctt cacctcaaaa 69360 cctagaatat ttactatctg actctttaca gaaaaagttt gctgatctct gctttgaaga 69420 agaggaagtc atcagataca gtgccaaaga attgctggct atgaaagaga tattgcagaa 69480 ttctataatt ttcttaaaga atggaaaaca ctggaaaaga gtcacctgtt tacaggtgat 69540 ttgcatttct ataggtatca gaataatgtg tgtgcttgta ggttggggaa ggaatggcag 69600 gcctctctct gtcagtatct tcaggccctg aagtcataca atcaatggat tgcttttcct 69660 cttcactttt ccattttgcc ataattttcc caagggggag gttggaagta ggtgaatatt 69720 ttgagctaaa agagcatttg gatacctcct gatagttact ttagctcaga tattcttaga 69780 ttctctctac tgaaggccac accttctctg tgcctcagcc tggcatggtc cagcgtgcta 69840 cttaccttgg gttcctgctg ctcagcttaa agggaatctc tttcatatgc ctagagcctt 69900 gtttactcag ttcaggtctg tgccagttga cgccaagtca aaaagcactt tagacagaag 69960 cttgctttga aagtgctagc tagtagcaaa taagtctggc ttaattcccc cttgagtctg 70020 gagatctgat tggaagagta aaagggagaa agggatgatt tatttgttga ctggattgac 70080 tactttatat tagtaattat gaggcaattc tacccacatt atcgcattta aatctccata 70140 aaaccctaca agggaggtaa tatgctttgg aaaactgaga ctcagagaaa ttaagtaaat 70200 tgcaaagtcc ttatgctata agcattatag tctcataagc aaatgtcatg agtttcttct 70260 agctttttcc tcatgctcac aaaatggttg aaggagatcc atcatgtttc tagttaaaaa 70320 gaagatgcag agtaacaggc aaaaggtaaa tggacaagcc aatcaagttt attctctttc 70380 ctagatgtcc tacttgatga cttcagctta tatctcatta gtctgcatca taggattatc 70440 tctgcaaggg aacctggaaa atgtagaaat ttgtgttaag ctgggcacct tgccacctcc 70500 ttaaaaatgt gctctatagg tacagagcag gagataatca ttattaatag gcaacttacc 70560 gtctctgttt caagaggtcg ttctggtacc tgagaagatt gacaatctct ggtctacact 70620 cttatagacc tctcttgcct tcatttaaga tgaacttgat agaataaaga ttattgttct 70680 tctctcatct cctgggtatg agacagagag gtaacagatg gaatgacttc cttctggctt 70740 ccatagcaaa ccaaagcatg tgccagtgaa gagtggcaac tgctacaaat acttagccaa 70800 acgtggggaa gagtgttgat gctctaagtc tcctagctat gtctaggcag caggtgtctc 70860 tgtagatcac ggcagcaatc cctttggtaa gggcatgaag agggcactcg ggactactgg 70920 attgcatcaa cttggcagag aaaaatgtag catgtactgg agctctagct gggtagggaa 70980 ttgacaagtt gaaccacaaa ttgactgctg ttcagtcagc actagctttt atcttccagt 71040 caccgttcca tgtggctctt cgttgatcat ccacaagctc caggcctggg tggtgcctgt 71100 tgtgatataa gaagggaaca gtgatgtctc caaaatgtga acactcatgt gtacagtttt 71160 catattggta aggaaatgct agaaggggaa cagctgtcag atgcctccct ctgtctttgt 71220 acatacctgg ctacccatgg caaagttgtt gttgtttcct tccaggcata gagccgcaaa 71280 tgtagaaaac aagcattcca gcctgcaaaa gaaaactgaa tcccccttgt ttggtcactt 71340 aaggaatcaa gctcaggagg gctggacgtg ttttctgttg ctctacaata ggggttgaaa 71400 cttagttcaa ttatggtgct tagctgaagc accatgactg aacctttttt tgcgaagggg 71460 aaaggagaag attttaaaat gaaatgccac aagtgtaaca tagtacatat agaggtcaca 71520 aacttggaaa gcctgtggtg tcttggaaga tcacataaat gtgtgaaaca cgccagttgc 71580 acacaggcaa gcacatgtcc cttctacaga aattattgcc acagaggaat gctggttcta 71640 atctccatcc tcccttcccc tcccctctgc tcctataaaa accagaggtt tggaattttg 71700 cgtgaataac tcagtttgtt agtgttgaca accagggatg acagtagctc atttgaaccc 71760 tttgtccaaa tcaggaaacc gcagcccttc cttcatggca gccctgtagc tgtgccagtt 71820 gagtgtgggc tggatttcag cccttactct ctcccttagc tgagcctttg tgccagacac 71880 aagctgccca actgtagaca gtgggctcag aagttatcag tgttacatga gcaaaagaaa 71940 acatatctat ggaccatact cagcccatag gttattattt tgcagcttct gcagctgtgg 72000 tcaaaacaaa gctctagggt cagatcacct gggtttcaat ctgggttctg cccttcaggc 72060 aaatgactca gtatttctcg gcctcagcct cctctatctg taaaatgaag ataaatactt 72120 gtacctacct aacagggttg ttatgaggat aaaatcaata atgtgggaca aacacttagc 72180 tctacagagg gtggcacata gcacttaatg ttatataata ccaaaatcat gtgaaaatct 72240 gattttttca gacttagaga attcacagca tatgaaatga atgggagagt gcatgtcaga 72300 cgtccatgat tattttctgc ttcttgagga aatgcttatg cctcttttgt cactgtgaag 72360 acaagagaac tcgaaatagt aagcattact tagcagctgg cctactaagg ccacaagaac 72420 aaatgaagta aacactctac ttgaaccact gattttgttt gcctgcataa aacacttgca 72480 caggttgaca gctaacatcc ataacaatga catcctaaaa ccattaagaa atgattaaat 72540 taagttcatt atcatctgtt gcaaaagaca aagatgtgtg aggtacgttt tagaataact 72600 tacaatgaaa acaactaaaa agtgtggaag tttaaagtgg caagtattca gttacttgag 72660 ttcatctgct gcactggtgt attctctgga agctgggcca cagagttaat attccatctt 72720 taaagactgt aacagttgtt ttcatctaag atgcatcagg ttctgcataa aaaatttggt 72780 tgctggcact gagactgtgc taggaggagg gtattaactt agtactgacc ataatgaaat 72840 ctgtggttga ctgcaaggac ttgggttgaa ataagactaa atccagtagt attgctctga 72900 taggttcaat catattcaag tgttcaataa tgattataaa gaaatgtcaa cctgtcatac 72960 ttactttaaa atatgtccag aaaagagaat ctaagaaagt ttatttagtt ccacctgcat 73020 gtaaattagc tttttttttt atcatgacat caatgtcatt aggccctaaa tgatattaag 73080 agtgtctatg agaccccaaa gacaaagatt gtccccaaaa ctcctattct tatttgttta 73140 acatggactt ggcccagcta ccttcaatct aaagcttctt tctctagagt aaggtatctc 73200 agtctttgca ctgttgacat tttgggccag ataattcttt gttcttgggg ctaccctgtg 73260 cactttaaga tgtttagcag cgtctctggt ctctacccac cagatgccag tgacctcctt 73320 cccctcaact catgacaacc aaaagtatct ctagacattg ctgtaatgcc acctggggag 73380 agaatcttcc tggtgagaac cactactctg gactaagaaa agtagccaga tttttaaaca 73440 cagaagtgtt tttcctcccg ggggcaaaaa gtgccctaga gatggaagaa ttttgaaaat 73500 aagctcttcc acaaactata ctgccaaaat ggttagagaa agatcgtata atcaccatgc 73560 ttgacaaatg atgtttttgc taagcctcac agcagctttg ttcatgtatt gtgttaattg 73620 caattaaata aactagtcta gaagtgtggg tcatcatcca gcccattcgt atccctcctt 73680 tacagtacac gtccagactt ctttcagaat tttgcttgcc cattggtgct cacatataaa 73740 aactcagtgg gtgagagtta gggattcata gagcagagag ggacctcagc ttttcatatc 73800 tacttttctt gttttaaaag acaaggcact gaggtccaga aagtggaatt tgcagcacaa 73860 attgctatga taaacctcag tgattcagcc cctcggatct tcaacaatat aggcacagaa 73920 catataacta ttactgagta aaatgtttaa aattatgttc ttatggcaat gttcaagatt 73980 ttaggcataa gtaagacaaa gcagaggcaa aataaaaaat acttttcaaa ttgaaggctt 74040 aaaaaattaa ggatatcctc tatgcacctt ctgctttagg atccagaaac ttatgtttgt 74100 ttgctcttta taacacatga ctgtgtaata tcagccaatt gtgactggta aatttccatt 74160 aatttgccta atcgtattta gaaattatgc ctactaaata aattatggtt ggaacttgaa 74220 aggaaaaatg gcttaaataa gtgatttgtt ctttagtcag aaaaatattc tcactttctc 74280 tctcttgaac cctcatgaag cactgccagc tccacctagt ttataattaa ggcaatggga 74340 ccaaagtcat cctgttagca caggctggcc atccctgtat ccaaatttct ttgactaatt 74400 ggagaaaacc actaattgta cattttaaac tcaaaatgtc tttaagtata tatatattta 74460 aaatatattt tatttttatt aatgtattaa ttataattat attttaaatt atatttataa 74520 ttatatttag atttattatt taattaaaat tataattata tttattaaaa taataattat 74580 ttttattaat tcatacatgt atataattta tgttttctcc atgtggttag ctgttgatct 74640 aaaggagaaa gagcaaggca gaaaaattat caggttcagt gtttaactga gagatgagga 74700 catcactaaa agaaaggtac agcatgttct accggtacat acaagttttg attacaaggt 74760 gtactcttgc cgcctgttat ggtatctcag ctaactttag tttgtgatta gtgggatctc 74820 tgagacaact ctccgtggtc aggtatagag ctcattttgc ccttggcatg ttccaaatca 74880 cttcctatgc tcaaccttct gagcaataca agaaaaactt cctagtgtgg catgttatga 74940 aggttatttt atttaatttt atttatttat ttatttattt atttatttat ttattttttg 75000 agacggagtc tctcgctctg tcacccaggc tagagtgcag tggtgcgatc ttggctcact 75060 gcaagctcct cctgacaggt tcacgccatt ctcctgcctc agcctcccga gtagctggga 75120 ctacaggtgc ccactaccac gccgagctaa ttttttgtat ttttagtaga gacggggttt 75180 caccgtgtta cctagcatga tctcaatctc ctgacctcgt gatgtgcctg cctcagcctc 75240 ccaaagtgct gggattacag gcgtgagcta ccgtgcctgg cggaaggtta ttgaaatact 75300 tcaggaaatg cctttgactt tgttttggac ttaagatgat gatttcattc agaaatgggt 75360 atagtgtcaa aatatggaat gtgctagtaa aataatcacg caattcactt aaagaaacga 75420 aaacaagaca aaacaaaata aaacttgttt gggatgggtg aaaggcatgg ggctgccgtt 75480 catcctgatt ttaaggtgag aagtggttga aagaaatgtg atatttttac ctaaaccatg 75540 gtcgactata ctttcacttt ttagcaatga tgtgaatgag gaatggcttt gaagactgtt 75600 ggtggattta acaaacattt atcaagagcc tgctgtgagt gccaccattg taggtggtag 75660 aaattccgca ataaacaaaa cagagtcctt tcttaaattt tgtgaaggga gaccacctgt 75720 aaacaaatat acgtcatgtc atgtagagat aagtgccatg gggaaaaaca aaatagggta 75780 agaggctagg tggagcagga tcagaccaag gaatttatat tttatataag attgtcaggg 75840 aatgcctctc taattagatg ccttttttgt tttttttaat agaactgaag gaaataaaag 75900 gacgaggctt atggatatct gggggaagat gtcagaggct gttataaaag ttacaacagg 75960 aaactgatta ggactcttag ccgacttata tatgcttaga atgaaaggga ttgggataaa 76020 agaaaagagg ggagctttgg gaaagcatta aactgtggcc acagtactga ttggataaac 76080 cataacactg gagtgtctgc aagtttctaa cattttttta aagtatcaga cccatagccc 76140 tagtaataag caacatggtc ttttctttta gcatggttgt aatgaacatg gtattctttt 76200 ggagttatcc tgcaaagctt acctactcgg gaagtaatag tttatatgca ttgcccaagt 76260 tgaatattat taatttgggt tgggaagtaa tatgaccaca ttctgactga ctataggccc 76320 tagtccagtt cacctgattt tatgcccaat ttttaatgag aagggagctt gctaggccag 76380 gcaggaagaa atggggacag tgtctaggag gaaatgcaga agagttgagt gtaggtaaat 76440 cccatctttc ctggctttac atcgccttca catccctcat atgatcttct accccagtct 76500 tcagtataag cagtattttg ttctgaagaa atgaagtctt ggccgggcac ggtggctcac 76560 acctgtaatc ccagcacttt gggaggccga ggcaggtaga taatgaagtc aggagattga 76620 taccatcctg gccaacatga tgaaacccca tctctactaa aaatacaaaa attagctggg 76680 agtggtggct tgcacctgta gtcccaacta ctcaggaggc tgaggcagga gaatcgcttg 76740 aacccaggag gcggaggttg cagtgagccg agattgcgcc actgcactcc agtctgggaa 76800 ctgagcgaga ttctgtctca aaataaaata aaataaaata aaatgaaata aaagtaaagg 76860 tatgaagtct tttccaagct aaggcaagaa tgctgaaacc tcaatcatag cacttttcca 76920 aaagagtctt accttatatt ctgaatctct tccttatctc aagaggggct tctttctctt 76980 taaatgtgaa aagaagagag gcatcagcta gccctattag cccagggcta agaattgctc 77040 cagatttttg aatgcttaaa ccttaaacta ggtcacatgt accagtggaa agtggctccc 77100 ctgttttcaa ggacagtcag attttaacta cctgcctctt aggcttgccc tgtctttggg 77160 gttgttaaat atgcatgttg ggagctgttg actgtttttt tttttttttt ttttttttgt 77220 cttataattt acttttattt taaatctatt atactttgaa ctgttgactg ttaaagaaag 77280 cagtactggc ttaggatcag cagagaatat gcttgaattc tatttcttaa actgaggaga 77340 atttctgttt gagcccagtc caagtcatta cttgagcaat tttttgtaca ttttgcttgc 77400 ttaagtgttt ttttttcttt ttgcttttac aagtaatttt tttaaggtta tcatacactc 77460 agcaaacatt ttttgagcac gtacacaatg cccagccctg tgccatgcat gttcgaaaaa 77520 aaaaaaaggt aacattatat ctgtgcttgt ggaattaata catttgttag aaggataaga 77580 cttcaatcaa taaagcaatc caagaaggaa caagtacaaa gcctggtagg agacattagc 77640 tcagtggaaa gagtccactg aggtaggtag acttgggttt gagtcagagc ttagactcta 77700 aacaagagtg tgcttttgtg agattttgct tatcctgtgt gggcctcagc ttcctcttct 77760 gtaaaatggg ataatagtac ctattacatt gtcacattgt attgctgtga tgacttgata 77820 atatttatat acaaagcaac cagtataata catgctcata gtaagcactt attatattat 77880 tattatttat tggacaaata attagatctg ggttataatc ttgattctac aattatttag 77940 tttcggtaaa tcacttaact ttatcatacc gttcatgcgt attacctata gagagaaggg 78000 aacagaggtt ctacaattta tctcccaaat tccatggtat tttgaaacaa aatgtattaa 78060 ataagtcttt gatgtatgct tctccttctt gttagtgata ttaacaataa caataaaaat 78120 caatatttat ttaggacttg ctatggagcc acgagtcgtg gtgggttctt gacattatgt 78180 tatttactcc atgctgcata ctcagtgaga cagataacct tgtcttgttt cctagatcct 78240 aggccatatt ttatccagtt taatatttct gaaatcagaa tgtattatat agttaataaa 78300 tatatttaat gtggaaattt tttcccaaaa gccctttcta agtgagatgg accctctttt 78360 aattgaggat gtcttccaag ggaaataaat attttttcta tatttctgat ggtacagttg 78420 aggcatagag aggataattt acgtcaccaa gattaatgaa gtaacaaaag caaatttagg 78480 acttgaactt aggtttgttt tatttaacaa tactcaccct accaacttct tgggagcaaa 78540 aaacttaaaa gtttctgaca tatattcatt aattctttcc attttttata gcaaaatata 78600 tttgatctat cactagaatg aatgatagat tgactattta ttaactttta acaggaatat 78660 attttagtcc ctctagcctg actttatagg ctatgtactc agcacatgaa aatatatagt 78720 agcctcaatt taatgttgat gtttatttga tgttgacgtc actagtgaca ctggtcaagt 78780 gtatcctttt agataagatc ctattagaat tatatattcc ctgtagaaat tttaccttga 78840 ccatagtaca tttaatagca gatttttctc agactttcaa aatcctgaaa gtctgggtca 78900 ttacaagaaa acaaggatgt ggtcataaac agttgattat taagcaaatt cattgaaaat 78960 taacagcagt attctttgac ctcactcttc atagccaaac tgctaatctt gggtaaatat 79020 aagattatat tactaatcca ttgacattta gcagaaatta gttatcaaat gggccagttg 79080 ttactgttgg aaacttatga aaatacatta aaattcttcc catttcctgt atgtttcttt 79140 ctctgacaca gaatcttaga gccttttatt aggctgggag aacttcccaa ataatctaat 79200 gactagttga ataattgtct atgatatcaa atcagctttg ttgtcaaaat gattacagtt 79260 tcagggtcac agttaataga aaaatattta agtgaaggtt accattctcg ttgtaagtat 79320 cctttgattc aagaagtgaa acttttattg aaaaaactgt ttgcagagct ggttccctga 79380 tggacctttc tgaagttttt aaaattaaga aatcctatct ctacttttaa caagacagga 79440 atgttagcat attcacccag actaaatgaa tgagtgaatg atcacattac acatgcttag 79500 gatttgattt ccttcctctg gtgttccaat agactagcag cttcaggact gaagtgtgat 79560 tgtaaaatta cacatggtgg aattcaaaat ggtgtacatc agtcaggtcc tggcaagaca 79620 cacaatctaa ctcagaagtt tcaagagact ttaagggaaa tgtacaaaag tatgggtaga 79680 attaaagtaa ctagcaagga atgctgaggc acccaggccc tagctgctat gagaagctgt 79740 tatctcctct gggcctggag ctgcagaaga aggaaactgt agtcctgaga gagctggagt 79800 catggaggag gggttctgtg acagaagcta gagttctgga gagacatagg ctaggccaga 79860 gcatagggga agacatccct gacctctccg tcaaccttct aatcgccgtt gttcaaaccc 79920 agtaggaagt tagccagcat tgagcctgta gagtcagccc acagcagtca gcctcctgag 79980 tgcagagcag aggaagacct ggagtggata tgccatagga ggaggaccaa atagagagta 80040 actagaccag atgggaaatg ctattttaga cctcatacac tgccaaaaaa gaatggcata 80100 ttcaaggaac gcagggcctt gacctcattt gatcttggat ttgcatccat tttgtgatac 80160 tttgttccaa atacccttgt aagcatctga cagcagccag gagaattgct ggtcagttca 80220 gcctgtccca gcttcatcgc tgaggtaaat atgtgtttaa ggagccgaga gggctggtct 80280 gatagctcac caaaggggga ctttcccaaa ggtacatatg tgtttaagga gcagagaggc 80340 tggtctgata gctcaccaaa gggggacttt cccagggaaa ataaagagaa aattcattga 80400 gaatctgtcc agaaaggaca gtaagtaggc atgaaatgat agtagtaagg aagcatggag 80460 gaggcaggtg cataaaaatg atttctgatg tttttgaagc tatgtgataa cgttctgatc 80520 cacactctta ccagcctcta caatcttctg gaggcttcat tggagagcag gattggtata 80580 ctgtttatta caaatagtgt ctgaagacct aagagatgat tactgtcagc ataagtggag 80640 atattacaca ttgcacctat ctcccagcag gaagtttgtt tgtttgtttg tttgtttgtt 80700 ttagacagag tctagttctg tcacccaggc tggattgcag tggtgcgatc tcggctcact 80760 gtaaactgcg cctcccgggt tcatgccatt ctcctgcctc agcctcccaa ataactggga 80820 ctacaggcgc ctgccaccac gcccggctaa ttttttatat tttttagtag agacggggtt 80880 tcactgtgtt aaccaggatg gttttgatct cctgaccttc tgatctgccc ggttctgcct 80940 cccaaattgg tgggattaca ggcgtgagcc actgcgcccg gcaggaagtt tgtgtttaat 81000 gtccctgttg tttcaccaat gtaaaagaaa atggatattt ttaaaagaaa agaaaaaaga 81060 tatcacactg tgtgatgaaa tttgtatcta tgggtggtca tttgctactt ggtaaataat 81120 taaagtctgt actggttaac tttcctttag cagctgacaa caaataaaca tccttacctc 81180 ccaccttata cactttactc catggttcat tgtcagtatt attttgtact tctcttgctt 81240 catcatacta ttgcctggca aaattccaac ccagatttaa tcctgcttcc catctatacg 81300 ctgcctacac ctgagagctc aatgttactg ttgaaaatgc acactgtggt ggcttgtttc 81360 agtttaaatg catgggccgt aacctcactg agccatttat tagtaatgac tggtaactcc 81420 tccatatttc tctaatccac tcactttcgt agtctcctgg acaactatgt tatagctcct 81480 ctctcctcaa gccttcaaca attatttctc ataccctatc tctgtgcaaa taaccttttt 81540 tcctatttca ctgcaaaaag cccagaagta atcaaaagtg aatctacatg ctcccaccac 81600 cacatctact cctcccagtc tcagtgacca tatggtttgc ctgccttctg ttaacagaga 81660 gcttctatct ccacctgaca ctttatttcc ctcttgcata ttcagggaca ttagctcagc 81720 aattttcttt ctttctcctt tcttgtatta tttattttct ccctccacca gatcattgca 81780 actgccatat aaacacactg aaatatccct gatcgtattt ttaaaaatga cacacacttg 81840 ttaatcctgt gccttccttc agctactacc acatttttct gtccctattt ttaacaaaac 81900 ttactgggag agttttctat actctattga ttatgatggg acggcagatg gaaactgctt 81960 ggctgctgtg acaatggctc accctatccc agttgctaca tctagtagca gatcctcaat 82020 tcttatcttc tttgacccat ttgatcaccc actcttcttt acttggtctc cacgacacta 82080 cactttcctg atcttcctca cacctcacag gtccttcttg tcagctccct ctgctctttt 82140 tgctccttac cccaacttct gttagaatga cttaagaagc acaggcctca cacctatttt 82200 tttttgtaca cctctacctc tattagcact cctgctccta ttttaggaat ccaggcttta 82260 atgctaacag ttacaaatta agccacaagc tttgtaagta tttgcctgtg ctctagctgc 82320 tagtgggttt ttggaaaatc aatatttgat aggcatttga atacatttgc tcttgtggct 82380 ttaaacaatg tctgtaaaat aaaaacttaa gaatttacct cctctgaatt ctagacattt 82440 ctattcaact acgtagatgg catttccact tgcatgcctt aaaggccctc aaccttatct 82500 gtactgagtt gatcacccca ctaactgcct catccgtcaa ttatccccat tgcagttggt 82560 gacattccat catttggttg cttcggttaa aaaatgttgg agttccccct tgactccctt 82620 ctttctctca tttcctaaag ccaattcttt ggcaaatagt aaccatttct catgttttcc 82680 cctgctactg tcctggtcca agccaccatc ctcattcact tggattattg caaaggcctt 82740 tacctatttt atctgctttt atatttgctc atttttctcc ctccacctct atattttgct 82800 ctcagcacat tatatcatct catgcgtcta ctcaaagcct tctaatgcct tcccttttca 82860 taatggcctg taaggccctt tgtgatatgg ttccctgaaa tccttgactt catttgggca 82920 gatgtttctg ttacaacact atttatgtgt tctgtaaaac cttttgttac acaagatgta 82980 ctttgaaaaa taacagggct tatggtaaaa ttacgattgg aatagagcac tcatatctta 83040 tacaacataa aaaactatag tactaaccaa agcaataata gataccttgg gagataacag 83100 gcaggcaggc agctcagatt gactgtaggc aattcgagga atattaaaaa tgcataaaaa 83160 cagtagcatg gacatgctga ctggggagct gagatgaggc agatgaatgg cgctctgagc 83220 cagagggcct accactaagg tggtcatagg aagaagttca gcctgcattg agcagatagc 83280 tttgcctggt gggagaggac atatttcttg ggagacacct ctgggtgcag gcactcatct 83340 ttagttccct taagagagct gaaatcactg cagtctgtgc agcagccaac ttcagggatt 83400 tttcctttcc tgataaggtt ataattctgt tcttgctatt cttgctcctc ttgcctaaga 83460 aaaatcttgt ttccatgtta taccaatatt atcccactat ttaccaatag catatgagct 83520 gcttgctgtc acagaaacac atgccgtaat atgctgtaat agaacagact gtaatccttg 83580 ggtcatcttt gctatttccc atgtgtcagg tgagcaccca ccttgtgact tttgctactg 83640 gtcttttcct acctggaata ctctccctcc agaaatcttc atagatttct tcatctatgt 83700 cagatcttta tttaaaaata tttttcatag tttgaacctc tctacctagc tgatttaaaa 83760 gaacaccacc accccaacaa cattctctac tttacatcat agtttaattt tctccgtagt 83820 atttatcatc tgatatatta tattactcat gtattggctg aaccacatcc ataaatatta 83880 agatccgtga gggcaagact tgtgggtttt taaacttgtt ttcttccttt gtttttctct 83940 attatatctt cagtgtctgg aacaaggtcc agcacataca aggcatttac taaatgttga 84000 gtgaatgaat gaattaagct caaactccat tacagtcctc tgggtttttt tttttttttt 84060 tttttttttt ttttttgggg ggggggtgta tgtattttgt ttttttgttt gttttctgtt 84120 tttgtgagct gtcatctggc ttttttttgt tgtttttgtt agataataat ttgtcttcct 84180 ttatttactg actttgtttt tatgtcttcc ttaggatgca tcagagtttc atgctgttca 84240 cactatactt ggggatattc agacatttaa agtcttaata tttcagcaat acattaaaac 84300 ttctggcctg gaaaaatact gtgatacagg ttgaatttat ctttttgcac ccctctgtca 84360 tcataaccac tccctgctcc ctcctgttct aggaatccaa gctcttatgc taacaattaa 84420 aaattaagtc cacagactgc aggtaaaccc tatgcttgag ctactggtgg gttgctggaa 84480 aattaatatt tgatggaaat ttgaattaat tgtctcttta ccccccctac caatccctgt 84540 gtatggtcaa aaaataggac attccaatac tccagggtga tggccacagt gctgaggtta 84600 taaaggagca ggaagatggt aatgaactcc ctctggtact ggacaagggt ggtgatgaaa 84660 acaatgcgag acgatggact caggggttct caaggcagag aatggtgagg ggatccagga 84720 atccacatat tcaaagacac aaagaagtac agatttctga tgtgttcagg gaatggcaac 84780 tcattagaca tgggggcgtt ggggcacagg gtaggcagag aagagagcag taggtgtata 84840 tgacatgaag attttggaat cgatccaact atacagctat caaaggtttt tggtgataca 84900 accagattcg tcttctcact ccttacctct ctcacctgat ccctctctgg cttttccaaa 84960 ctgtcaacta taaggctgtg tgaccagaga gcatgcccct ggccacagta ctcagatgag 85020 tgcctgacat atatatagag agaaaatctt cttgtttatg tgtctgaaca aactattaat 85080 attcatttct gcattttctt tacagcaata cttacactgt cttcaaatcc tttagggccc 85140 tgcacctgac tatcaggctg cccattggaa actaacttta cagactgttc attgattact 85200 ataatggcat gagtaaccat tcagtaactt tttttttttt ttaactagaa ttgaaagctt 85260 tgatccattc tctttttctg gtgtcatttc ccttctgcca ggtctgattc atggtgcaac 85320 ttttggtggc atcaccccca actccagcaa catttttgtc caccctgagg ttattacttt 85380 gatgtcctga acttatggct ctgggggata ttttttttaa gggatcagag agataaggtt 85440 gaattagaga gattcttaga agtttatgat taaaacactg tcccctctga tctgagtccc 85500 agctctgcca ttgacaggtt gtatatcatt agcaagctcc ttcacatttc tgaatctcac 85560 ttgattgagc aaaatttaga tctcaaagac tactggagat gtgatgcttt cacacaaaga 85620 aatctacctc tttggtgaaa tttcaattgt ttaggagcaa ttatttggaa gaaaagtgcc 85680 ctctcacctt cttaaatcat ctcctagggc tataatagga aatatgcagc ttttgctgag 85740 aacccaaatg acattgtgga ttatccagct ctagtcttct ctctcccata tagaggtcgg 85800 ttatctttcc cacttcagca gcccaactca gggccatgga gaggaaatag atgagatgaa 85860 gcttaaatat gtcacattag ttatttctta gcagctctga taaaagcttt agcaggggcc 85920 gggcgcagta gtgcacgcct gtaattccag cactttggga ggccgaggca gcggatcacc 85980 taaggagttc gagaccgcct gaccaacatg gagaaacctt gtctctacta aaaatacaaa 86040 attaaccagg tgtggtggca catgcctgta atcccagcta ctcaggatgc cgaggcagga 86100 gaatcacttg aactcaggag gtggaggctg cggtgagcca agatcatgcc attgcactcc 86160 agtctgggca acgagagcaa aactctgtct caaaaaaaaa aaaaaaagaa aagaaaaaaa 86220 aggttcagca gggtgaggtt aaaacttgat taaagaggtc tgaggattat ctgtgatgtt 86280 aactcatgta tgttgccttc ctctcttccc ttctttgttc tagggattag ttgactttgt 86340 tctagggatt agttgttcta ggaatttcta gggattagtt gactgcaaac attaatgggt 86400 taaatataaa aaatcttttc tatcctgaag gtccttgaaa aaaatgattt tattacttac 86460 cggaaaagaa aaataaaaca aagtttactt cacccagaat ttatttattt tttcttctag 86520 taaaaatgag caacttcttt aaccagaact gaccttgaag acaaatggct aaaataaaac 86580 atttgctgaa ttcactgggc gcatcttaca agtaattttt ggattctgca ttgactgcct 86640 acaagtgcct tctgggtaca agtccacaga caagatttgt tctgcaaatc ttccatgacc 86700 aaggtcacct ctttggattg gcagacccag ggagtccatg ttgggaagat aaattcacac 86760 ttcatccctt gttgagatct ccagccttgc tcctctgata actaaccagg tctttcttct 86820 gtcttattat aatttatgac ttttgaaaag tgaattatat ctggggttac tcaaactctc 86880 agctatctat aaccatatac agaaatggtt ctagattctt taaaaaaaag aagctattca 86940 gtgatattgg gatactctat aaccaatata aatggataat tcagcacacc aggtgctggg 87000 gttgagaaat agaggtgaac aattgaggca gggccaaata aagattggag gcaaagacag 87060 tgactagatg gggatctctg ataaggtaat gcacaggcct gtccttggaa ttctgccaca 87120 gtggggacat tagtgggagc ctgtagtcat tgcagggtga gaggaggata gaaagaaaag 87180 attgtgtgaa ggtcagtgga aggtccccca tttcactggt aagagaacta tgtatgcaag 87240 ttttcctgtg tttagtctca cacatgtttg gacctttaag aactgatcac gtaatgcatt 87300 tccctgacag tttttggcat ctcagacgag gaagagtgat gggcgacagg tgatggtgac 87360 aactattaat aagatctgaa agcaaacagt ctcatgaaag gtggccagga gagggcagtc 87420 accttttttc aagagtacag actgaatttg caaagagtac ttaggctaca aggctataaa 87480 gcatgatgca ggcttaagta aaatgcagtg tcttgagcat agtagaatct tagtgtatgt 87540 ttgctaaaca taccttagct gctgcttttc cccagagctc atcagagttc catagaaacc 87600 tggtcccttc cagaaaacca aagaatgact ctaaagaaaa gtgattgcaa atccagaaag 87660 cagctttgcc ttattggttg gtaacagcag ggttttcttt cccttgtagt ttattttggc 87720 ttaggctagt gtctctttca tgaagacagc tactatttac aattgttgtt aacatgtttt 87780 tccttttcat ctcccaatat actctcttcc tgtcattaaa ctcagtcaat ttactaatgg 87840 aatctgcttt ataagctgct gcattttctt tttccacaga tgggattaaa gccattatgt 87900 tctatgtcat ccaaatagtg ttagcttcta ggcaccaagg tgttgttcca gaggaaagga 87960 gaataatggt ggacacaggc aggctgaggg ctaacctaat gatttcatgc atttagtggt 88020 aatccttaat taagatccca gttttatttt gttggattta gtctgtaacc tgctggaaat 88080 cattcttgaa ttaacactgg gtggttataa aagcagtaag ccaaggagtt tgcacttttt 88140 tcagctgtag ctgtttattt agctggagaa aatttagtgg gtggtccaac cttcataacc 88200 aggaagaata gaatagaggt gtaaaggcct tggtggaagg agggcagtag caacctttcc 88260 atttcttcag ttttatcaca gcttataaaa ttagttcatt aggtatgttg atcttgtagg 88320 agctagtatt ttaacatttg ccccatgaag ttgtttagtt taaatctaag aataaaccca 88380 ctgaaaacta ttcctaattc acaaaatgaa taagaaataa tagatgttaa tagaaacaaa 88440 gacttcattt ggtttgtttt tagagggggc acagaggatg tagtaatata ataagttaga 88500 tttttgttgt tttctttgtc tttgttcttt gtagtcatta ttatctctaa ttggtatttg 88560 ttcctgagtt ttctcagcgt gcttccacat gggagagata aaagtctcaa agctggtgta 88620 caaaaaccct taataaattg cccattaatt agccaccttg atttccacct ttaaagcagt 88680 ttagtgaagt gagagtttgt tagatttttc tcaagcatag cagaaattaa gattaacttc 88740 ttaggtgtca ttgctacttg cctacttaaa ccagttcatc tttatcataa atatttaagc 88800 caaaaatcac attagaggca atatggcaca gtgactgtgg actccggagt caggtgagct 88860 ggttgaaatc ctggcttggc tacttcccag ctatgtgacc ctgggcttca gggttccctt 88920 ttgcaacatg acatgattgc tgagcttctc cttagggttg tgtatgactc caataagata 88980 atacatgaaa agagctgaaa gcagtatctg accctggaga gaaagtaggg aagagacaat 89040 gaaggaagga ggaaagagga caaggaagtg ggagatagaa agaaaattca agaaggaaag 89100 tggaagaatc tcaaatagaa aattaatttt cagtttttcc tgagaagaga tatatagaca 89160 tgttcatgtg gctttggaga gccttggagc ccatcagcaa gaggtttgga aattacattg 89220 aaacagaagt gtagacctat gtgacttatg tcctggccag ttgcctcatg tcctctgtgg 89280 tcagattgat ctctattggc actgtcaaag gattttttat ggacagctgg ttggggtaaa 89340 ctttgaaacc tgattgtttg cacttgagtg ccagaatgtg taattattta ctggtgttca 89400 ctaaggatgt cactgtagct ttttaggggg agaaagaact taagtttaaa atttggaggc 89460 atctttttca gtctgcctgc cctggtgttt gttataacac ttagtttggc atgtaacagc 89520 tgaacctact ggttaaatca ttaagcattt attattttaa aactcatctt ctcaaagcga 89580 aaaataacta tcatgttgaa gttctttcct ctaagaatga catttactgt gagttttata 89640 ccaatggact aattgaaggg ttgagaaaat aaattttgga aagacaacaa taacttcaga 89700 attttccttg gatggaggtt ttctttttaa aacctgaact gagctttatc aaaacagtaa 89760 ctgaactttg aaatgaaaca agagtgctga gttgaaagct ccaggaaggc agggatgtgt 89820 ctgcgttgtt tatgactata acctctgggc ctaaatcagt acctagccca tagtaagcac 89880 tcagtaaatg ctgaatgaat gagtacggtt ttaaaattag catgactgtt ccttggaaaa 89940 aaaataagtc aaaagggaat agcatgcata tgtaactaaa tgtttgaaat ctcatcactt 90000 ttttaaggtc aggacctgtt tttttctgct ccaattaaag aagaaaattg taatgtaaaa 90060 gaagcataaa gtgaaatatt tggtatttat ttgttttgac atctgcaata aatttaaaat 90120 aaatttgtaa atcttattgt attgaaattg tatgagtttc ttaagtggta ttattcattc 90180 agacttaaag tgaagttagg ttgctgtcat tcatagtgga catttttttt tcattattaa 90240 aacaacaggt cgtctgggtg ttgtcttgta ttacagaagc ttgcgtgttt tctcttgatg 90300 ctgtgccgtt tctattgcca ttgaggggtc taaggaccaa atgaggtctt attccctttc 90360 tgatatattc ttttggccag tttagaatat gccaggtcca ttcacatgac taactggctc 90420 agttctgtca gttccctcgt cttctcatat tagattgtta tccatgagct tgaagtttag 90480 acataaaaaa gaatggttat aattctcttc cttcactccc cctcttccct ttttttcctt 90540 aaagttggcc ttttgaattc attattctaa taattaatat tatatattat tatataatat 90600 agtatatatt cataataatg attaatgata gtattaataa ttgtgtgtgt gtgggcggat 90660 actcatacag aggaaaacaa tgagattgat tggtggaaat tacattaatt tcataacctc 90720 ttattaaaag agtttgtgtg tgtgttgttg cttgtttgtt ccctttgcaa ctcaaataac 90780 atggtcttct tgaggtgcag ggaaaacata tgcttaggaa acagagcctc cttttcccct 90840 tttggtatga agacatatgc aaaaagaatg aaggaactca ttgtctctag ccagggcgct 90900 gtaaaaatag tactggtaga gaaaaagctc taagagaagt aaaagtttat agtgctttct 90960 cctggcagag ttaacctcat cttcatcagc ttttcccctg cctcagagag gcagttttgg 91020 aatgaccaaa gcagagtgcg caagctctct gttcagagtt agctagcgtt tggatcactg 91080 tctctctctg ccacagtatg agtggaatat tgcatgacca tttctgactt ctacattgag 91140 cacactcggc ctagatgaat aaatcctcct tgaagaaggt ggggcatttt ggcattcaca 91200 agaaaccaag ttgatatctg atcctcccac tggagaaatg tggcaaagtg agaaagactc 91260 actctttggg actctgaaaa tataaacaca aataaaaatt caagctgaag aagtcacttg 91320 aagtaaaaaa aaaaaaaaaa aaaaaaaagt gttaaactct gttagtcatg tgactttttc 91380 ttggcattca aggagccagg aggctcttgt ggtctaatct ggaaagagtc gctaatcgct 91440 gtgtcaccct ggcaaattgg ttgatctcct tgtgctggag tgtttagtcc agctgctgga 91500 tgggatgaaa gcaagacctc actgaaacca gatgctgtct ctctgaaaag atttcagcaa 91560 taaataatat catatatact ttgttcctgg cggcaaatac tgaactgtta taaccccctg 91620 ttttcacttg cttctaaatt tctgaaaata tctcctttgg gcttgaattt ttccatgctt 91680 ttcttcagcc caaaactttt tggaaagttt gaccaaaatt tcacttagct gtttttcctg 91740 aattatggga gaataaaggc attgcattgt ttttcagctc ataaattcta atttttccca 91800 ttatacctca gaaaaatagc tgagctgcta cttttaaagt gtttagaact agtaaaagaa 91860 tcttggtatg gtaaagaata ctggcagaag acaaatttaa gtctctcagt atttctttct 91920 aactctaaac atgaccccac acaaccagga cacacataaa aagctctggt atagttttat 91980 agatgaccaa agagaagatt ctgcaaattc tctcagtaac tcatcccaag ttaccaagag 92040 gcaactttag ctaccatcag ttgcaccttt cttaaccact tgctctatgt ctgtggatct 92100 gatttctaaa aagatgtcat ggttatatgc tggcattaat tgaccctttg tctatatttt 92160 aattgaagtt gaccatttct tttaggtagc cttcatgtgt gatgacctca gtcacatctg 92220 ctgacctagt agactgaaaa ctcctttaca gcaaggccta cgtctgtctc cctcaccatt 92280 gactctgcag tgctcagcag ggtatcacgc atgtagtaaa aactgattat tgaatcaatt 92340 aaatgaccat aagtacaatt gtttttactg cagttttttc attgatttgt ccactaagat 92400 atgcatgcat gtgttgagtg agtatcactg agtctctact ttatgccagg tattggtatg 92460 aatgttgtga atatttcttt gctttgatgg gtgacacaga agtttggggg gattaattaa 92520 ttatacacaa caaaataatt atattatttg aatacaatta ctatgcctat agttggaata 92580 ttagtccaat ctagccaaaa ccaatcccag ggaatttatc acttactgag catccatgat 92640 gtgcctggcc ctgtgttagg tactgataag agatcaatta gaccagttta tgcagaaaga 92700 cacacatagg ttaacagtgg caagacaaat cctaaagtac ctattataca agggaaacta 92760 taataaagag ccaggtgagt tgaaagcagg agaggtatca ttgtaccaca agatacctcg 92820 tgatcttgtg taaatcccct gaacaatcag aaaaagcgtt atggcatagc tttatggtca 92880 tagatctcat ggggacaggc agttcattgc aattcctttt atagccgcat ccttcactct 92940 ttaaccctgc actgtatgcc attcattctc tctgtgcttt cagccttggt caaatgtctc 93000 aggactggaa aataaactgg aatgacactc aggcacttga tatcaagatt actagggtca 93060 tgattgtatg tataagaccc caagacctct tgatggtttt acaagcatgg gtactttttt 93120 tgtacctatg ttttcttctt ttgccccaag ttcaagagta tgttacagca gcagtataag 93180 catacacaat caaaggtgat tgaagtgagg aagattggct caatgagctc cagccacttc 93240 gactctcctt ctagtcccta acccaccaaa ctaattgtcc ccttgcctgg aatgtttcac 93300 cctcagattt tggcatagca ggcttctttt tgtcattcag atctcagctc aactgcaaga 93360 ctttctctga cctaaagtta catatgagtc accccttctg gtctccgttg ctgtctatca 93420 catcacctac tgtgcttcct ttatagcatt tatctccacc taattgtgtc cttctcagtg 93480 tttttcttta aactttttat tgtcagtttt ctttcactag atgtcagttc catgaagtag 93540 gaaaccttta ccaccggtct tgagtgctct ggaaagtgta tgtgtgcaat aggtgctcaa 93600 taatgtttac gaaatgatca gctggatgta catatggcaa gtggcaagaa gccaagggaa 93660 taggtcaaaa gtcctattgt gctccttgcc tgaacaaaac ctcttgcaag aatcataggc 93720 tgttcttgag ggtgcctttg ccttggattc agcccaaaat tctcctattt gttttgtgtg 93780 agagttttcc tcccatacac agcaatgggc actaagaatg catatatcca gacttttcaa 93840 gttacaggat ggcatctcag atacagtctt cctttggtct atatactatg aagtcataat 93900 tgcttaagcc agtgtctttt tcaggattta ctccgtactt cttattcgag gcctttcagg 93960 tggccactgc cctggctttc agatataatt tagaatttag cttcggattt gtaaagctat 94020 tcatgttgca gatcttctct gaaacatttc tgtcacgttt tggaaagctt tacattttct 94080 tttgctaatg attttcatct gccaaagagc tcatctactt aaaaagcaga tcactgaagc 94140 cacacttggc acatattact ttggcttatt ttctttcgat ttttttttgc ttttctggga 94200 taacttattt atgaagaaag agagaacgct gactttttaa tttagaagag aggatattac 94260 ttgcgttgag agttctagtt atataaaatg tatttatcta agttgttaac tatatcaaaa 94320 atggagcagt caatgtttgg aaatagttcg gggtgaaaag attttagcgt gttcacatat 94380 tctcttagct gtttttaaat aattttgcaa agcttatttg catttcccaa attaacaatt 94440 ttgaccaaca ggaaaagcta aagtgttggt ttttctcagc tcaacttttt gggtgtaatt 94500 aatttataag caggatttta tgaagggaga acagatagga cctttctaca aagtccctga 94560 gccaaataaa caccccattg ttccatagtt ttgtattgca cataggaaaa catccatccc 94620 tatcattttt ctattaaagg gacacagatt accagatttg taattttaaa aaaggccatt 94680 tgttgattga gccactttgc gtataaaggg tggtatatgt tgcctgccaa atttctgtca 94740 acacaagaag aaaaatcata tatcaaaaaa aattttttct catatcatgt aagaaattta 94800 tgcattttag tatgtaccag aagaaatggc ataggcattt tctgttttta gcagtctatt 94860 gaaatttctt gattaaagac attttctatt tgaaggttaa aatgaccata taaatacaga 94920 ttaattcagt tttaatagat gcatcttcct gtcatttacc actttcctcc ctcaacatca 94980 gctgcagtga tcaacatata tttggcagtg aaaccgatat attctgttta tcttcaaatc 95040 ataagctttt tgtttaaata caacggaata tcttatacct ctgattttaa tatgacaaat 95100 caaaaagtcc acaccaaacc cccaactcat cccaaaaaag agattgctat ctactcatta 95160 ctgttcactg cttccaagat ttgtttccct tggggttact gtttgagaaa cttttcttac 95220 ttccaagatt atttttctgg ttttaagaaa gaatctgaac tccaagattt ttttgtttgt 95280 ttgttttcag aaagagtctg aaaatctaga gattgcttac cttgtggtga ggtggttgtc 95340 tatgcctctg ttcaacaaag tcctcatata ctgaatggaa aaaaaaacat cagggcctat 95400 aattttctaa gcattgtgca agataataga ggagacaaaa atgatgtctt gcttcagaag 95460 tcttagatct atttctcttt gggggttgag gaatgagaaa gattttcaga tgaaacagga 95520 agcccaatga ggattatgtg gcaatagttc ctaaaatgag caaagagata aatttacttt 95580 tgtatatgat tacaaccaaa tcacacactg gtgagtttca aaacagtagt tttcatttag 95640 aaagcaaatt aagtggaata attcaactga gtttcactgc aatgggattc attctagatg 95700 gttcaactgt ggaattagaa acaatatcta aggatgttgc tgatagtagt cagctgatga 95760 ataccagtga gccatataca ggtatacata attttattgt gctttgcttt attgtgtttt 95820 gtagataatt gtgtttttac aaattgaagg tttgttgcaa ccctgtgacg agcaagtctt 95880 ctggctccat ttttccaatg acttgtgctc atattgggtc tctgtgttac atattggtaa 95940 tccttgcaat gtttcaaact tttttattat tattatatct gttatggtgc tctgtgatga 96000 gtgacgtttg atgctattat tatattgttt tagcacacta tgaattgcac ccatataagg 96060 tggggaactt aataactaaa tgttgtgtgt gttcttactg ctccactaac tggctcttcc 96120 cttatctctc tccttctctt ctggcttccc tatcccttat ctctctcctt ctcttctggc 96180 ttccttattc cctgcaacac aacaatattg aaattaggcc cgttattaat gctacagtga 96240 cctctacatg tctgatatgg tatagttgtg tccgcaacca aatctcaact tgaattgtat 96300 atcccagaat ttccatgtgt tatgggaagc acccagggga aggtaattga atcatggggg 96360 ccgatctttc ccatgctatt ctcgtgagag tgagtaagtc tcactagatc tgatgggttt 96420 atctcatgag atctgatggg tttatcaggg gtttccactt ttgcttcttc ctcatttttc 96480 tcttgccacc accatgtaaa aagggccttt tgtccccagc cattattctg aggcctccca 96540 agccatgtgg aactataagt ccaattaaag ctctttttat tcacagtttc gggtacgtct 96600 ttatcagcag catgaaaaca aactaatacg gtaaattggt accagtagag tggagtattg 96660 ctgaaaagat acccaaaaat gtggaagtga ctttggtagt gggtaactgg cagaggttgg 96720 aacagtttgg agggctcaga agaagacagg aaaatgtggg aaggtgtgga gcttcctagg 96780 gacttattga ataactttga ccaaacagcc tgataacaat atggacaatt aagtccagac 96840 tgaggtggtt tcagatggag gtgaggaact tgttgggaac tggagaaaag gtgactcttg 96900 ttatgtttta gcaaagaaac cggcagcatt ttgcccttgc cctagagatt cgtggaactt 96960 tgaacttgag agatgattta gggtatctgg aggaagaaat ttctaaacaa caaagcattc 97020 aagaggtgaa tgtttgggtg ccattaaaag catttcattg tgaaagggaa acagagcata 97080 aaagttcaga aaatttgcag catggcgatg ccatagaaaa ggaaaacccg ttttttgagg 97140 agaaattcaa gccggctgca gaaatttgca tgagtagcaa ggagcctaat gttgattccc 97200 aagaccatgg ggaaaatgtc tccaagccat gtcagagacc ttcatggcag ccctcccatc 97260 acagacccag aggcccagaa ggaaaaagtg gttttctggg ccgggcccag ggtccctgtg 97320 ctgtgtgcag cctaaggact tggtgcctta tgtcccagct gctccagctg tggcggaaaa 97380 gggccaacat agagcttggg ctgtggcttc agaggatgga agccccaagc cttggcgctt 97440 ccatatggta ttgagcctgc aggtgcacaa aagtcaaaaa ctgaggtttg ggaacctccg 97500 cctagatttc agaagatgta tggaaatgcc tggatgccca ggcaaaagtt tgctgcaggg 97560 tcggggccct catgaagaac ttgtgctagg gcagtgcaga aaggaaatgt ggggttagag 97620 cccccacaca gagtccctgc tggggcactg cctggtggag ctgtgagaag agggccgctg 97680 tcctccagac cccagaatgg tagatccacc aacagcttgc actgtgctgc ttgaaaagct 97740 gcagtcactc aatgccagcc catgaaagca gccaggaggg aggctatact cggcaaagcc 97800 acagggtgga cctgcccaag accatgggaa ctcacctctt ccatcagttt gacctggatg 97860 tgagacatgg agtcagagga gatcattttt gagctttaaa atttgcctgc cctgctagat 97920 ttcagacttg catgggccct gtaacccctt tgttttggcc aatttcttcc atttggaaca 97980 gctgtattta cccaatacct gtactcctgt tgtatctagg aagtaactag cttgcttctt 98040 attttacagg cttataggca gaagatattt cccttgtcta aagtgagact ttggattgtg 98100 gacttttggg ttaatgctga catgaattaa gactctgggg gactgctgag aaggcattat 98160 tgcttttaaa atgtgaagac atgagattta gaggggccag ggccagaatg atatgctttg 98220 actctgtccc tacccaaatc tcaactcaaa ttgtatctcc cagaattccc acatgttgtg 98280 ggagggaccc agggggaggt aattgaatca tgggggccag tctttcctgt gctattctca 98340 tgatagtgaa taagtctcat gagatctgat gagtttatca ggggtgtccg cttttgcttc 98400 ttccttattt ttctcttgcc gccaccatgt aagaggaccc ttttgcctcc tgctgtgatt 98460 cggaggcctt cctaatcatg tgggactgta agtccaatta aacctctttt tatttccagt 98520 tttggatatg tctttatcag cagcatgaaa acaaactaat acagtgtcca agtgaaaggg 98580 agaatcacaa gtctctcagt ttaaatcaat taagcttagt gaggaaggca tgttgaaggc 98640 caatataggc caaaagccag gcctcttgca ccacagagtt ttccaagttg tgagtgtaaa 98700 ggaaaagttc ttgaaggaaa ataaaagtct actccagtga atacacaaat gattaaaaaa 98760 aaaaaaaaaa aaagaaaaga aaagaaaagg aaagaaaagt gaaacagcct tagtgctgat 98820 atggagaaag tttgagtggt ctggatagaa aatcaaacca gccacaacat ttccttaagc 98880 caaagcctaa tccagagcaa ggccctaact ctcttcagtt ttatgtaagc tgagagagaa 98940 agctacagta gaaatgttgg aagctagcag aggttggaag tttaagaagc catctatata 99000 ataacataaa agtgcaagat gaacctgcag gtgctaattt agaaactgca gaaagttatc 99060 cagaagatat agctaagatc agtgatgaag gttactaaac aacagatttt cagtacagac 99120 aaaatagcct attggaagaa ctaagacttt catagttaaa aaggaaaagt cagtgcttgg 99180 cttcaagact tcaaaacttc aaagggaagg ctgatccttt ttttatgggt taatgaagtt 99240 ggtgacttta agttgaagcc agttctcccc agccttgcta gagagaccta aagtcaaatt 99300 caggaaatac agagaacctc tgcaagattc tacacaagaa gatcataccc aagacacgta 99360 attatcagat tttccaagat gaaaatgaaa gaaagaatgt taaaggcagc tagagagcaa 99420 gggcagatca cctacaaaag gaaccccatc tggctaacag cagacctctc agctaaaacc 99480 ctacaagcta gaagagatgg ggggtctata ttcaacattc ttaaagaaac aaatcttcaa 99540 ccaagaattt cacatccagc cgaactaagt ttcctatgtg aaggagaaaa aagattcaaa 99600 gcaaatattg cgggattttg ttactaccag acctccctta taagagatct tgaaaggagc 99660 actaaatata gaaaggaaag acagctacca tctaatacta aaacacgctt aaatacacag 99720 accagtgaca ctataaagca accacaaaag caagctatta taataaccag ctaacaacac 99780 aatgacacta ccaggttcac acatatcaac actaaccctg aatgtaaatg ggctaaatgc 99840 ctcacctaaa ggcacagagt ggcaagctgg ataaaaaagc aagacctaat ggtatcctgt 99900 cttcaagaga cctatctcac atagccttaa aacaaagggg tggaggaaaa tcaaccacgc 99960 acatgggaaa caggaaaaag caggggttgc aatcctaatt tcagacaaac agactttaaa 100020 ccaacaaaga tcaaaaaaga caaagaaggg cattacataa tggtaaaggg ttcaattcaa 100080 caagaagacc taactaccct aaatatatat gtacccaaca caagagcacc gtattcataa 100140 ggcgaggtct tagataccta caaagagaca tagactcaca cacaataata gtgggagact 100200 tgaacactcc actgacagta ttagacagat catcgaggca ggaaattaac aaagatattt 100260 aggaactgaa ctcaacattg gactaaatgg atctgataga cctttataga actctctacc 100320 taaaaataac agaacataca ttcttctcat cacccacatg gcacctactc taagactgat 100380 catataattg gaaacaaaac aatcctcagc aaatgcaaaa taactgaaat catacaattt 100440 caaaaatcat agggccctta agaattatgc taaatctact ctgtctatag tctataaatg 100500 gaacacaata catgtgtaat agtacacctg tttacattat ggcttgctga atattttaag 100560 gccacagttg agacctcctg cacagaaaaa gatttttttt tttctaaata ttagtcctca 100620 ttgagaatgt acccagtgac caaggggctc tgatggagat gtacaaggag gttaatgttg 100680 ttttcatgcc tgttaacaca atgtccattc tgcagcctat ggatcaagga gtaattttgg 100740 tctttaagtc ttattactta agaaatacat ttggtaaggc tatagctgcc atagatagtg 100800 attcttctga tggatctaag aaaaatacat taaaaaactt atggaaagga tttaccatcc 100860 aagataccat ttaaaacttt tatgattcgt aggaggaggt caaaatatca accttaacag 100920 cagtttagaa gaagttgatt ccaattctca tagattactt tgaattgatt cgagacttca 100980 gtggagaaag cagctgcaag tgtagcggaa atagcaagaa aacttgagtt agaagtggaa 101040 cctgaagatg taactgaatt gctacaatct catgataaaa cttgaacaga tgaggaatta 101100 cttcttatgg atgagcaaaa aaatagtttc ttgagatgga atctactctt ggtgaagatg 101160 ccatgagcac tgttgaaatg gcgaaagatt tagaatatga cataaactta gttgataaag 101220 cagcagctag atttgagaag attgattcca attttaaaag aagttctgtg ggtaaaatgc 101280 tgtcaagaag tatcacatac tacgcagaaa tcttttatga gaggaagaat caatcaatgt 101340 gacaaacttt actgttgcct tattttaaga aattgccaca gccaccccag acttcagcag 101400 ccacccccat gatcactcag taggtgtcaa cattgagaca agactctcca ccagcaaaaa 101460 gattatgact cactaagggc tcagatgatc attagcattt ttagcaataa agtattttta 101520 aattaaagta tatatattgt gcttttttta gacataaagc tcttgcacac ttactagact 101580 acagcaaatt ataaacataa ctttttttta attttttatt ttttttgaga cagagtcttg 101640 ctgtgtcacc caggctgtag tgcagtggcg cgatcttgtc tcactgcaag ctccgcctcc 101700 caggttcatg ccattctcct gcctcagcct ccctggtagc tgggactaca ggcgcccacc 101760 acaacgcctg gctaattttt tgtattttta gtagaacccg ggtttcacca tgttagccag 101820 gatggtctcg atctcctgac ttcatgattc gcctgccttg gcctcgcaaa gtgctgggat 101880 tacaggtgtg agccactgtg cctggccaaa cataactttt atatacagta ggaagccaaa 101940 aaattgtgtg gcttgcttta ttgggatatt tgcttcctta cggtggtctg gaactgaact 102000 gcagtatctt caaggtatgt ctgtattcaa gtttatattt tcacatacat tcttctttac 102060 ttgttaaaat catggtcacc tcgttattat atgactcatt agaatttgca cggttgcttt 102120 gaccgtatac cattgttcta cgactacaca gatgtctgag tcccaaaggt gaatctgtct 102180 ggccaattct gaatttaaca gcctatataa aaagtagatg ttacacacct tgtataacag 102240 aagcccccta tcatgaacac agcttaactc ttgggtgggt cacttagtct gcttggttga 102300 gattttagtg cttttcacat ctatagaaat gtcctatttg tctaaggcaa ttttttgaag 102360 taaatttatt cttgtcatcc tttccgacct gaatatagag gatatataat ttttaacatt 102420 ccattattac ctaggggatg ctcttcagtc attcttccct gaattgattg cactagccct 102480 atctttttca cctgaaataa gttaaatgta gaattagcac taaagagaaa tacgatgaac 102540 tccttccaga atgggaatag gaaatgaaag agagtaaatc agaagtgaat cacttttttt 102600 tttttttttt tttttttttt tttttttttt tttgctttgc aaatctatat tttttccagc 102660 tttatttagg tatgactggc aaataagagt tgtatgtatt caaggtgtat gacatgatga 102720 tttgatatat gtgtacattt tacagtgatc accacaatca aattaataca tccttcacca 102780 cacagttacc atttgtgtgt gtgtgtgtgt gtgtgtgtgt gtatgtgtgc aagaggagat 102840 aagggagttt aatcattttt gaacactagc tacaacacaa ttcaattaaa attctgagaa 102900 agaaggaaaa ttgtcatgca gctgtttaat tttagaagca ttaactgaca aaatccaagt 102960 cttatgagga atactcagtc caattttcat gaatgaatgg gagcccttgc ctctgaaatt 103020 gttgtcatgg aagaaatgct aacactgtct tacacaatta ttcaacttac caattgaatt 103080 aaagtaacaa gatgagccat ggttgtaact gagaatggca actaaggtct tcttatttaa 103140 tctgctacct agtttgcctt tttgctttag agtggggact atgtttgaat tcaaagaata 103200 aaagaccttt atcctttcag gggagataca agtaacaagt ttaacttttt tttttttttt 103260 tcttaacact gacgcaactc atttggggct gtggaaattg ctgctagcat tgaacccctt 103320 attaacattc aaggtgtgcc agttttgcac aagctgtgtc atattcagag acagattgtt 103380 ggcacaaact aaggcactta ttctcttgtt ttttcacctc tttcaataag aacagataaa 103440 tataataaat atactatttc tagataagca gttgaaactg ctctgctcat ctctttggaa 103500 tacatttgtg cgggatatta ctgtatgaca tgcagaatat ataaatatac aaaggaaatg 103560 cgcctgcata cattgagata taaatggatg cctattttag aataatatat tatttcttaa 103620 aagtaaaata agttttggct ggtcgcagtg gctcatgcct gtaatcccag cactttagag 103680 gccgaggtgg gtggatcacc tgaggtcaag agttcgagac cagcctggcc aatatggtga 103740 aaccctatct ctactaaaaa tacaagaatt atccaggcat ggtaatgtgc acctgtgatt 103800 ccagctactc agaggatgag gcagggaatt gcttgaaccc aggtggtgga ggttgcagtt 103860 agctgagata gcaccgttgc actccagcct gggcaacaaa gtgagagtcc atctcaaaaa 103920 aaaaaaaaaa agtaaaataa gttttttaag tcactgattc tgtttctaag gaattctcag 103980 ctggggcttc tgagttaatt ctcgatggtt agcacttatg agtagcagaa aagaaaacta 104040 ctgtgaattt tctctacaat gatttaagac agtgaatggg gctttctggc atgtttgcag 104100 ttaggaactc agatgaccat agattttttt tttttagact gggtcttggt cttactatgt 104160 cacccaaact ggagtgcagt ggtgtgatca tagctccctg cagcctcgac ctgggctcaa 104220 gtgatccaca gatttttgaa gttcaccctg gattgttgtg ttctatacag aggttctacc 104280 ttttgctgcc ttttatggtt gctgtattat tattttgatg tttcttaacc agctgaatca 104340 cattgtagta tatgaaatat gttttggccc ttgttttaat ggtcatttgc tagcagattt 104400 cacaatggcc cacttaagta aaatgtacca acccattcat tgctatttgt tgcaattcat 104460 ggtgactaaa catgactcca tggtgcagct caccaaagtc ttggtttatg tgtgacttcc 104520 aggggagaga gattgagaac catctgttaa tcattgtgtc cctaaactag agtttttcac 104580 tagagtagtt gggcagttga attagtatgt ttctcgtagg ctagtgagaa aaacagattt 104640 ttgggggaca ttaatcagac tctgctggcc cagacctctg ggaagccttg tgacaagatc 104700 cagcctgtaa aatatcacat atgatttgct tttcttcttg aaagggacac attgtggctt 104760 ttctctggaa tctgtgaaga aaatgcttct gagcctagaa actggagttg agaaagctct 104820 tcctgatcat ataacaataa gtcttgtgag ggtcacccct tgagccatga gggcaggtag 104880 aaggaacatg gggttgagag tcatggattc agtgattgga actcacttga ctaaccagtg 104940 tagctctgcc acccctctta ggattgttac agtgatatgt gcctacatat agaaagtcat 105000 cagaacttct gtttattttt ctgtgtaata tttatggact tgttacattt aactctaggc 105060 aaaggtatag atttggaggt ctttgatgta tatatattat atataatgta ttttagcata 105120 caaaggaggc tataatacat actcatgtac ctgtcacatg aatgaattca tcaaatgtaa 105180 acttttttcc caaatctgct tcttagctgt tatttataaa gaaacaaatt atacagaaaa 105240 atttgaaggc ccccatttta ccttccccag tctcattctt ttctctgcca ccccagagaa 105300 aacaactgtc ttgcataggt atttatataa ttctgtttta tactttgcca cttttactac 105360 atatatgaag catgcttgtt acatacatga acataaaata tacatgtttt actgtaagtg 105420 tgtaatgtat tctagaattt gctactttac taccaaatat tttgtttcca gaatttacct 105480 tgttattata taaccctagt tcatttttta aaaaattgcc atatattact ccatgttatg 105540 aaaataccac aatttattta ttcccatact aaccagaatt tgaattgata caatttttaa 105600 ttaaaattaa tgatgctgaa agaaatgttc ttatacattt ccctcagggc atacgtgata 105660 gagttcttct cacatatata tcagtgtact tgctgtgtct taggatttgt acaattgcat 105720 gtctgttaga tacgccaaat tgttctgcaa agtactcata cctgtttcca ctcctaccag 105780 caatgaatga gaactttgtt tcccaggtcg ttgccaacac ttgattatta tcagatttaa 105840 ttatttgcca gttgatggat atgaattgct ctatcattgt tttaatattc attactttga 105900 ttatatataa cattgggcat acattttata gggccattta aatttcctct tatctgaatt 105960 acttatttct cctcttcatt gattcttcta ttatcttttc ttctctttat taatttatag 106020 aaatgtgtat atgtgtgatc ctaatatatg tcataatacc tatgttcata tttcgtatat 106080 atgtataaag aaatatttgt ctgttatata taggttgaaa agtttgctcc ctatctgctg 106140 attgcatttt aattttgttc atgacatctt ttaacataca tgatctttaa ttttgatata 106200 gttaattttt ttttactcta cattttgaga attgcttaag aaatgacttt attttgtata 106260 gtcatatgct ctaaattttt aaatctactt acgatagttt tatgttaaat atgtcaacct 106320 ttgtttcacc gggaattttt ttatatgtat ggtataaagc ataaatcaat ttttttacta 106380 ttaagaatgc ttttattata ttatatctta ttttattcta tttttatttt tccataagtt 106440 attgaggtac aggtggtatt tcgttacttg agtagattct ttagcggtga tttgtgagat 106500 tctggtgtac ccatcacccg agcagcatac gctgcaccat atttgttgtc ttttatccct 106560 catccccctc cctccctttc cccaagaccc caaattccat tgtatcattc ttatgccttt 106620 gcatcctcat agcttagccc ccacttatca gtgggaacat accatgtttg gttttccatt 106680 cctgagttac ttcacttaga ataatagtct ccaatctcat ccaagtcatg ccattaattc 106740 attcctttct atggttgagt agtattccat catatatata tgatagaata tatatatgtg 106800 tgtgtatatg tatgtgtgtg tgtatataca tgtgtgtttg tgtgtgtgtg tgccaacaga 106860 cgtcagggtg gcaggtactg gggggtccct gattcctgct gcttaccttt cttgctgcca 106920 atggtcctta aaatccaaac atgatgccct ctctgtgtga gcaaatttgg ggaaccaaag 106980 gaaatcaagc ttgtaaacaa gcagtaaatt ttcccaggca caatttgttt ttgctcccca 107040 aaagtacaca gatagaaaat tttgtgagat cagaccagtt tttagtattt atccagcata 107100 atcatttggc ctaagcaaac atgtaaaggg gcttcttttt gaggctcaat gaataggccg 107160 ttaaagtaaa cgattccatc tctccagacc ccgacacgct caaattcact tgaagagaaa 107220 cactttttaa tgctgaattn nnnnnnnnnn nnnnnnnnnt tgagccgagg agtttgaggt 107280 tgcagcaaga tatgatttta ccgctgcgcc ccagcctaaa cttcagagca agactctgtc 107340 tctaaattaa aaacaaaacc aaaaaattct actacagcat acgttttatg gataaatttt 107400 acaccaccat tgaaacaatt ataatacaat cagtgcattt tggaaaaaaa gaaaaagaaa 107460 aaaggaaagg ggaatgatta tattatacta gtggtagggt attccctaac accatatata 107520 tacacaccag tttctttatc cactcgttga ttgatgagtg tttgggttgg ttccatgatt 107580 tttcaattgc gaattgtgct gctataaaca tgtgtgcaag tatctttttc atataatgac 107640 ttcttttcct ctgcgtagat acccagtagt aggattgctg aatcaaatgg tagttctact 107700 ttagttcttt aaggaatctc cacactcttt tccatagtgg ctgtactagt ttacattccc 107760 accagcagtg tataagtgtt ccctgatcac cgcattcgtg ccaacatcta cttttattac 107820 ttttttttat tatggccatt cttgtagaag caagatcgta ttacattgtg gttttgattg 107880 catttccctt atcattagtg atattgagca ttttttcacg tatttgttgg ccatttgtgt 107940 atcttctttt gagaattgcc ttagcccact ttttcatggg attgcttgtt ttttttttct 108000 tattgatttg tttgagtttg ttgtagattc tggatattag tcctgtgtca gatgtgtaga 108060 ttgtgaagat tttctcctac tctgtgggtt gcctgtttac tctgctgact gttccttttg 108120 ctgtgcaaaa gctctttagt ttaagtccca actatttatt tttgttttta tttcatttgc 108180 ttttgcattc ttggccatga aatccttgct aagccaatgt ctagaagggt attttccaaa 108240 aatactacaa tattttctag tattttgata gtttcatgtt ttagatttaa gttcttaatc 108300 catcctgagt agatttttgc ctaaggtaag agatgaggat ccagttttat tctcctatat 108360 gtgactagcc aattatccaa acatcatttg ttgaaaaggt gtcctttccc cactttatgt 108420 ctttgctttg tctaaaatca gttggttgta atatttgggt ttatttctgg gttctctatt 108480 ctgttccatt ggtctatgtg cctattttcg taccagtacc atgctgtttt cgtgactatg 108540 gccttatagt acagtttgaa atcaggtagt gtaattcctc cagatttgtt ctttttcctt 108600 atttcttgct ttggctatgc aggctctttt ttggtcccat aagaatttta gaattgtttt 108660 ttctaattat gtgaagaatg atggtggtat tttgaagggg gtggttttga atttgtagat 108720 tgcttttggc agtgtggtca ttttcacaat attgattctg cctatccgtg agcatgggat 108780 gtgtttccat ttgtttggtc atctgtgatt tctttcagca gtgttttgta gttttccttg 108840 tcgaggtctt tcgactcttt tgttaggtat attcctaatt attttatttt ttattttttg 108900 tttttttggc agcaattgta aaaggggttg agttcttgat ttgattctct gcttggtcac 108960 tgctggtata tagaagagct actgatttgt gtacattaat cttgtgtctg gacattttgc 109020 tgaattcttt tatcagttct gggaactttc tggaggagtc tttaggtact aaaatcttta 109080 gggttttcaa gttaaacgat catatcatca gcagacagtg acagtttgac ttccttttta 109140 ccagtttgga tcccctttat ttccttctct tgtctgatta ctctggctag gacttctagt 109200 actatgttga agaggagtgg tgagagtggg catccttatc ttgttccagt tttcagaggg 109260 aatgctttca acttttcccc attcagtatt atgttggttg tgagtttgcc ataaatggct 109320 tttattacat tgaggtatgt ctcttgtatg ctgattttgc tgagagtgtt aattataaag 109380 ggatgctgga ttttgtcaaa tgctgcttct gcatctgttg agatgatcat gcaatttttc 109440 tttttaattc tgtttatgta gagtatcaca tttattgact tgcataaacc atctctgagt 109500 ccctggtatg aaacccactt gatcatggtg gattatcttt ttgatatgtt gttggtttca 109560 gttaactagt attttgttaa agattttagc atctatgttt atcaaggata ttggtctgta 109620 gttttctttt ttggttatat cctttcctgg ttttggtgat gctggcttca tagaattgat 109680 tagggagggt tctctctttt tctatcttgt ggaatagtgt caaaaggatc agtatcaatt 109740 cttctttgaa tatctggttg aattctgctg tgaatccatc aggtcctggg cctttttttg 109800 ttggtaatcc cttaattacc atttcattct cactgcttgc tattggtctg ttcaggttat 109860 ctaatttttc ctgatttaag ctgggagagt tgtatttttt cctggaattt atccatctct 109920 tctaggtttt ccagtttatg tgcataaagg tgttcgtagt actcttgaat gatcttttgt 109980 atttcagtgg tgtcagttat agcatccccc attttgtttc ttaatgaagt aatttggatt 110040 ttatctcttc tattcttggt taatcttgct aatggtctat caattttatt tatattttta 110100 aataaccagc tttttgtttt atttatcttt tgggtttttt ttcttttaat tttatttagt 110160 tcttctctgt tcttggttat ttcctttctt ctcctgggtt tgggtttggt ttgtccttgt 110220 ttctctagtt ccttgaggtt ttaccttaga atgtcagttt gtgttctttc agtctttttg 110280 acataggcgt tagagctatg aactttcctc ttagcaccgc atttgctgta tcccaaaagt 110340 tttgataggt ttgtcattat tgttgttcag tccaaataat tttttaaact tccatcttga 110400 cttcattttt gacccaatac tcattcagga gtagcttatt tagtttttat gtatttgcat 110460 ggttttgaag gttccttttg gagttggttt ccaggtttat tcaatgtggt ctgagagagt 110520 acttgatata gtttcaattt tcttaaattt attgaggctt attttatggc ttatcatatg 110580 gtctatcttg gagtaagttc catgcactgt tgaatagaat gtgtattctg cagttgttgg 110640 atgaaatgtt ctgtatatat tggttaagtc catttgttcc aagtacagtt taaatccatt 110700 gtttctttat tggctttctg tctggatgac ctgtctagtg ctgtcagtgg aatgttgaag 110760 tcctcactat tattgtgttg ctgtctctct catttcttag gtctattagt aattgtttta 110820 taaatttggt acctccagga gttaggcaca tatatgttta ggattgtgat attttcctgc 110880 tgcacaacct tttttaccat tatataatgt ccctctttgt ctcttttaac tgctgttgct 110940 ttaaagtttg ctttgtctga tataaaaatc actacccctg ctggcttttg gtgtacattt 111000 gcatgaaatg cccttttcta acactttact ttaagtttat gtgagtcctt gtgtgttagg 111060 tgaatctcct gaaggcagca gatacttggt tggtgagttc ttatctattc tgctgttctg 111120 tatcttttaa gtggagcatt taggtcattt acattcagtg tcagtatgag atgtgtggta 111180 ctgttgcatt catcgtgcta tttgctgcct gtgtaccttg ttttttttgt ttttggtttt 111240 ggtttttatc ttgtattttt gttttatagg tcctatgtga tttatgcttt aaagaggttc 111300 tgttttgatg tttccaggat ttgtttcaag atttagagct ccttttagca gctcttgtag 111360 tgccagcttg ctaggggcca attctctcag catttgtttg tctgaaaaca actgtatctt 111420 tccttcatat gtgatgctta gcttgctgga tacaaaattt ttggctaata attgttttgt 111480 ttgaggaggc tgaagataag ggctcaatct tttctagctc gcagagtttc tgctgagaaa 111540 tctgctgcta atctgatagg ttttccttta taggttaccc agtgcctttg cctctcagct 111600 cttagaattc tttcttttgt cttaactcta gataacctgg taacaatgtg cctaggtgat 111660 tatttctttg cgatgaattt cccaggtgtt ctttgtgctt cttgtattta gatatctagg 111720 tctctagcaa ggctggggaa gttttcctca attattccct caaatatgtt ttcccaaact 111780 tttagatttc tcttcttcct caggaacacc gattattctt aggtttggtc atttaacata 111840 atcccagact tcttggaagc tttgttcgta ttttcttttt ttttctttgc cttcattgaa 111900 ttgggttaat tcaaagacct tgtcttcaag ttctgcattt ctttcttcta cttgttcaat 111960 tttattgctg agactttcca gagcattttt catttctatg agtttgtcca atgtttcctg 112020 aagttttgat tgttttttct ttatgctatc tatttccttg aatatttctc ctttcacttc 112080 ttgtgtcgtt tccttgtgtc agatttcctt gcattgggtt tcacctttct ctagtgcctc 112140 cctgattagc ttaataacta acctcctgaa ttctttttca ggtaaatcag agactttttc 112200 ttggtttaga tccattgtta gtggactagt gttactttgg ggggggggtg ttgaagagcc 112260 ttgctttgtc atattaccag agttggtttt ctggttcctt ctcatttggg ttccttctca 112320 tcctgtcaga gggaaggtcc attgctgaag gctgttgttc agattctttt gtcccacagg 112380 atgctccctt aatgtagtac tctccctgat ttcctatgga tgtgattcct gttagctgag 112440 ctgaagtgat tgttatctct cttctgggtc tagccacgca acaagtctac ctggctctga 112500 gctggtactg gggattgtct gcacagagtc ctgtgatgtg aaccacctat gggtctctca 112560 gccatggata ctagcacagt atttggggtg tctcctgcgt cctccaggag ccgtccactt 112620 ccttcagagg gtctgtgggt cctctcagga ttcctggttc attcttgaag tctagatcta 112680 ttttttaata ggctaatcct aaaaccattt actaagtaac attctttttt tcattgttct 112740 gtaatgcttc ctctgttgta aattaagatc ccgtaaatgc tttagtcttt gctagacttt 112800 ctttttctcc tgttgtttta aaattttctc tcccaacaag atatcatatt gtgtaagtac 112860 tatatgttca tagtaagcat ttttatctgg tactgaataa tagtgagaat gcttcaaaat 112920 ttcactttaa gtatgctatt aggtactgta tagctttttg gctgacttat ttttgtcagg 112980 ttaagaaaac tgctctctat ttctagttta ttatattagc ctataaataa tggtttttct 113040 gcacagtaga ataatcattt gattcccact tttaaattat taatgcagta gattatattg 113100 gtagatctgc ctggtattaa actatcctta cattcttgat ctaaagctta tttgaatggg 113160 atgtgttact gtattctctc tctcgctctc tctctctctg tctctgtatc tctcttcctc 113220 ttttcatctc tcctcgggaa catcttaaag catattttgg taaatttgct ttttatagtt 113280 attgattttc agaaatattt ctttgagaag ttaaaaatgc aaaggtttta tttcactttg 113340 tttcaaatat agtaattatc tacaaacaag aatcgtccat tttctaccta ttgagactca 113400 aaacattcac agaacataaa cctacttgtt tcaaatatag tcgttatcta agaataagga 113460 ttgtccattt tctacatatt gtgaatgaaa acattcaaag aacataaggc caaaatatct 113520 ctttcttttg gttctaacct gtgggaagcc tgtcactttt ctaaaagtca tgatcaggct 113580 gagcttcact ccccnnnnnn nnnnnnnnnn nnnnnnnnnc ttgtttttgt tgtctagaat 113640 taactttcat cttctgatcc acatgaaatt tgttccatgt tgttttttac aagcaatatc 113700 tagttgaatt acccaccatg ttttactttt ttctcaccat tagttcattc gtctaataaa 113760 ttcttattgc gtgccttgtg ttggcctgct attatacatg cctggaaata taggagtcaa 113820 caaatgtgtc tctgaactca tgtagttgac aatctaatta gagaacaaag atgataaaca 113880 agtaaacaag taaatatata tcaaaaataa gtgccatgga gaaaaaataa gtagtataag 113940 ggttgttatt tatctaggtt gtcaggcaag ggcctgttac agatgtgtga catttgaatg 114000 catacttgaa ggaagtctgg gagaaaagta tcccaagtag agggaatacc atatactaat 114060 tgggatcttc aaggaacatc aaagcggcca gttttgttgg agcaggatga gcaagaagaa 114120 cgtagcggta aatggaggca gagatagtgg gtgagagtgg ggttgagaaa aaaatcagat 114180 aggactttca gacccctgta tatacttggt catttactct aagtgagaca ggatgccatg 114240 acagggccct gaaaagaaaa aggggacatg ttcttatttt agtgagacca atttgagtgt 114300 tgggaataag gagattcaaa agcaaaagca ggtaggccat taagaaactg ttataataat 114360 ccagataaat gttggtggct tgggtaaggg agataaagat ggagatgata agaagtgatc 114420 gcattctgga tgtaatctga agacatgtct gagaggatta gttgacagag tgttagttat 114480 ggggtatcag tgaaagaata gaggaaaggc ctgagaatct gaaaagatga aggtgatatg 114540 aaatggccta cagtcttgaa tgagtagatt aggaagtaaa attgaaagtc tggttatggg 114600 ttttataagt ttgagatacc tataaaacat tcaaataaat tattaaatag tgaactgggt 114660 atatgagcct gtaattcaag aaagaggtct ggattaaagt tattatttgg acaacattgt 114720 cctacatatg ccattagtgt catgattcca aatgagataa tctagggaat aatcatagag 114780 aaaaaaggag aggaggataa tttctggtga tatttcaatg ctaagtggtt gggaaaatga 114840 agagaacaca gtgaagttga ccaagatgaa gtatttactg acatggaaga atcaatgcgg 114900 aatgttgttc gagatacaaa attaagatag tgtgccaaag aagggggagt gatccgttgt 114960 ggcaagtgtt attcattggt taaataagat gattaagaat ttgccgcaat gtggaagtca 115020 ttggtgacta aagcaaaact attccattgg tgtgggggag attaaagcct gatttgaata 115080 agtttaagaa attgagcaaa gaggaattaa agacaggaga ataagacaat ttcttcaaga 115140 agttttgatt tagaggggag cagagaaatg ggtcagtaac ttcatgggca gtaactgaaa 115200 taggagaaaa ggtcttttcc tcttttttaa aaaggagaga attttagtgc acacttaagg 115260 tgattctttt cttcctgcaa aatttttcaa aattttattc atgtatattt ctattccaat 115320 cgtttctggg gtacaagtga tttttggtta taaggttgaa ttgtatggtg gtggtaaagt 115380 ctgagatttt agttcatcca tcacccaggt agtgtacatt gcacccaata tacacttttt 115440 gttttgtccc tcagcccccc taccccctcc tcagtctcca gtgtacatta tgcctttgca 115500 tacccgtagc ttagctccca cttataagca agaacttcgt ggtatttgat tttccattcc 115560 tgagttaatt cttttagaat aatggcctcc agctccatcc aagttgctgc aaaatacatt 115620 atttccttcc ttttttatgg ctgagtagta ttccatggtg tacatatacc accttttatt 115680 tatcccctta ttgtttgatg ggcacctaag ttgtttctac atctttgcaa ttgtgaactg 115740 tgctgtgata aacatacatg agcaggtatc tttttgatat aatgacttat tttcctttaa 115800 gttgataccc agtagtgaga ctgctggatt gaatggtaga tctgctttta gttctttgag 115860 aaatttccat attgttttcc atagaggttg tactaattta catcactacc agcagtgtat 115920 aagtaatcct ttttcactac gtctatacca acatttattg tttgttttgg gtttttgttt 115980 ttgttttcat ctttttataa tgtccattct ggctaggata aggtggcata tcattatggt 116040 tttaatttgc atttccctcc tttacgtatt atttaatgag agtcttttgg tggtaaagta 116100 tcttagtttt catgtgtgct cacatacaca tacacagagt ctttagtgac aggctagttg 116160 ggtatcaaat tctgaattga ttttttttct ctaatacttt taaagtttat ttttgtcctg 116220 gcatctgttg ttactaaaga aaaatcttcc actagtccat ttgagttcat tagtaggtaa 116280 tctgcctctt attttaagta cttttaaaga tttttctgta tcttgatgcc atatgataga 116340 tctacttttt attatacttt acttagtaat tactgtggac ttttaatctg ctaactcaat 116400 tatttgattt tataaaatta tcagtaatga ccttttctat aactgattct ttacagttga 116460 attaaatcct ctctttctgg aattcccatc atatgtgtgt tggagcttct caatctaccc 116520 tccaaggctc gtaactgctc ttttaaattt ttcagtacta ctgtcttaat taaaaaaaaa 116580 aaaaaaaaaa accaaaccta atattgcagt gtttggcaca gaagaagttc aaagtacaac 116640 tttgcagtgc cacgttgacc agctatcctg gcattggtta ttctttaaag ttatttttaa 116700 ggttaatata ccttgtcagg cagcaggtct caaaacctag ggaagcttaa aagcctaaag 116760 gcagcctgga aaaaatcaag ctaattaaaa tgctctttcc cattttctct tcctcctatg 116820 ccctcatccc taaagaatag tgatgaagcc ttccttaaaa agatatgtat aaaatagcag 116880 aaagaaaaag gggatccagc aaacatgcga agacatactt agataattca cagtaaatgt 116940 tccaaataat attcagcctc actaattctc aaataaatgt aaaacaatgg cagatcattt 117000 ttatccatta aattagtggc aataggagga aaagaacatt ttgctgacaa ttgtaacagt 117060 gaaattgaaa ttctcttctt gtctggtttg aatctaaatt aggacagttt gaaagcaatt 117120 gggtcatatc tatgaaaaat ctcataaaca ttctaccctt ccatgtagca acattgcttc 117180 tgtgaatcaa ccattaggca ataaatggaa ataacaaacc aaatttcccc ccacctccca 117240 agagatgttt attgtaacat tactgataat attgaaaaat tagaagcagt ctatatcagc 117300 gacccaccct tgttttgact gtcacttacc ataagaaaat attaggtcta caacgtaacc 117360 caacagccac acccatgagt caaaaacttc catataagga aactgttcaa tccattctat 117420 ttatttaaac acgccaataa acaaagctgg ttttgatcca ctaaactgat cctaaaacct 117480 aggagtaggt tatgactcac agtttgaaaa gcaccaatct gaatgtccta tgaaaggcat 117540 atgatggaat atgaattaaa tttgatattc acaatttttt attttgtttt tgtttggggg 117600 tagttggagg ggtactatgt ttcctcagcc agcaaggaag ataatgtttc cagataactc 117660 catataatgg ggatttactg taatgatacc agctctgttc tactatgccc agtcattctc 117720 gtgtatctat ctctcaatac accacgggtc ctttatggat tcttttgtga tgtcttcaag 117780 ctccctgtcc actctcttgc aacttgtcca agctgataga acctgcctga atcactcaac 117840 atctgatttc aagcatttta ttttggtcag cctttggtat taggacttca ttctcaatct 117900 aatcaattaa tattagctga gctaggttga tttcatttga atcaacaaag aattgctaaa 117960 agctgcattt cctagaaaat gtggcaatat aattggcagg tacttgagag tctctaatgt 118020 taaatggaaa aaaaaaatga aaaataatga aagagacaac tttttatatg gagtctgttt 118080 tcagttttat ttggatattt tgttagagac aaaaaaggaa tcctaatata gtataaaata 118140 aatttctaca taagcaagta ttatgcattt gtaatcagaa aaaatatcaa aattagctct 118200 gtggaaaatg atcatcttgc aagcaagtat catgtaccct tcctcttgat ttagctcatc 118260 ttcttgatgt aaatatgaag tgtctgtgac tgaaattctg tttgaagcag aaactttcat 118320 gtttgtctta caaataccat ctcagagtac gttgctcagt ataaaactta ttttgggggt 118380 tgggtacaaa aacctgcaag gatatagtcc aggcttcttt tcccaaggtc cttcactttc 118440 ctactcttag tgtaaccatt attttgtaaa atttgataag acccttaata acttggggtt 118500 tgggaatttg atttgaagta acatggctca gagtatcacc tattttttat taaaccaaaa 118560 aaaaatttct atctgacaaa gatgtgcatt tatgtgggcc ttaataattc ccccaaataa 118620 aactattcat aagttctaac agttccaaat acttctggtt tcagcacact aataggattt 118680 ataactgtct tagataagga gcagtatctt ctaaagctca tggaaaagcc atatcagaat 118740 gccatgtgtt caggtacatt atcttttctt tatgatatca agaataaaat ctcggcttat 118800 gtttttacac aagtcttgtg tgattactct ttcccattac ttgttcaatt gagcctgaca 118860 aatgaggtga aaaaatcttt ctctttcaag gatgaactag aaagacctag gctggctggt 118920 cacaaaacca ctgactagtt ggccctttgt ctttttataa cccctcattg tctgggatcc 118980 aacatcgtaa tgagtctcag acatgttcct caagtctaga tagacctcat ccatgtgttc 119040 ggtgatccag cccgtcagca tccaagccag cagtgtgaga aggggaagtg taggggatgc 119100 tcattgccct gaaggatgca tatgccactt ccagtcaggt cctgctcgcc agaacatagt 119160 catgtgacca cagttagaca caaggttggc tgagaaatgc ctttcgctag gttctatttc 119220 taactgaaaa taggaggagt gaaagttggg ataactagta aatatcagtt agtccaagtc 119280 atggattgtg gtattaattc cataagcaag gaaagtcatt taaatgtttt atgcagaggg 119340 ataccatgat gataattatg tttcaaagcg tgtttctgtg tgtgagagag agagactgaa 119400 agagagagtg agataaatgg attagagaga atttgtctgg gtattaagag gccattctca 119460 aatccaagtg agaaatggtg gctagtaaca gtagtgagga taaagaggga tggaatggac 119520 tcaaaagata cagaagagat aacatcaaaa gatgaaacgg gtagaggagg aagaaaagac 119580 atccaactaa ctcctaagtt tctgatttat actgcaaatt ctggagatca ggtgtttatg 119640 gaccactgag tttagtttta gaaatgtgct ttagaggtat ttgtcagata ggtggtttct 119700 acacattcaa aataagattt caaaacatat tagccacaaa ttcacaatca gcaaaattct 119760 caaatttggt cattgtcaac taaactatta aaatgaattt tcccctctga gtgtttctca 119820 tcttaaaggg tttgtatgta ttacatgtca cagaacggtt tattgcatat aaacatggga 119880 aagcaagcca ggcagaagaa gtcttgtaac cagctaaagg cccagctaat aaatcatgaa 119940 cagtcttctt gtattaatag tgtggacagg actgttggtc acacacagga aaatgagtca 120000 cacagtcttg tgtgtacagc aactcactcc acactcagtg atgggaatga ttgttctaac 120060 cgtgtgagtg gctacaataa ttatggcaaa gctccagagc tagaaagctg gtcttttttt 120120 tttttcagtg tcactcgagt atgtaattca ctaaatgttt agtattttat accttttagt 120180 tgacttgtga gcgctttcta aaagaggtat atttccctct attagaaggt aatcaaaaaa 120240 accctaaact gcattttcta aatgctgtgt tcttctgccc aattgaccaa aatatactca 120300 gttgattagg actttgaagg gttggggtga ggggactaaa ttaagatgca ggaatttcag 120360 ttttctaggg gttttctagt caactacttt atactgctga caaatggtta aatgtttaca 120420 atgaaactaa gtatgctagg atttctaatg agcaatgaaa ttttagaatt catttactca 120480 ttaatttttt catttacaag atgtacaatg tgctgtcttc tgggcatttg ggatacttta 120540 atgaggtagc agtgagtaca acggatggtc acttctgcct ttgttcttct actctttaga 120600 gaagggaaag gaccaagatt cagataccct atcactgctt tcaacccatc cacatcagag 120660 cctttgttga gttctaatgc ttagccctct tctcagctaa tttggctgcc tccattgtaa 120720 taggcctcat gagactccag cccaggcctg gcctttggtt cagcaggcag agcccagaga 120780 tgtactgggc aaaggtcagg ggatttatta tatgaggcaa tggtcgggtg tgatttaatt 120840 tactcctctg gtaccagata tgtgtgtgtg tgcatgagag agagagattg aggatgattg 120900 attttggagg aatttttgtg aaggtttata tatcaaagca gaaagaccaa gaagttagag 120960 attaatacat gccaagtcgt gaccaagaaa cttctgtggg atcccacctc caacccctcc 121020 ctctctgcca gattttaacc aaatcagtgt gatgtgatct gcttgcatat atgagtgaaa 121080 gaaaaaggaa atttaaaaag ttcttgatat aaagcctgga ggaaacaata cgaaaatcca 121140 gcctctattt cagcaatatc tgccggacta ttggttagta ttcccttact gttatttatt 121200 gtttgattaa aaggctgata gtcagggttt tgttttggtt ttttttttct acttactttc 121260 gcatttttta gatataaatc tttaacgtgg ctttgaccag atgttttcct ttctcctccc 121320 acttcattct tccctcttct gggttaattt ctctcattgt tctctcttcc ctttacttct 121380 ctgccctttt cctttctact ctaagcgaaa cttctatttt cgtgtgctgg agtttataaa 121440 gtattcttat taggcaaaga aagcctttgg ctgccctcct ccttgtctgg tcaccatcaa 121500 gatataattt tggttttcaa aggttgttct ctgaaggaag gactagtttt ctgagcattg 121560 agacagcaga tacattttga gaaagtcaac agggatggta atttgcatta agtaggaaat 121620 acttaagggt tttaattctg ttccatgtgt tacatttcaa cagtttacat taagaaaagt 121680 attgtaggcc gggcgcggtg gctcaagcct gtaatcccag cactttggga ggccgagacg 121740 ggtggatcac gaggtcagga gatcgagacc atcctggtga acacagtgaa accccgtctc 121800 tactaaaact acaaaaaaac tagccgggcg aggtggcggg cgcctgtagt cccagctact 121860 cgggaggctg aggcaggaga atggcgtgaa cccgggaggc ggagcttgca gtgagctgag 121920 atccggccac tgcactccag cctgggcgac agagcgagac tccgtctcaa aaaaaaaaaa 121980 aaaaagaaaa gaaaagtatt gtaaagaaaa gtgatacaac agttgcatgt ttattttgta 122040 tgtttagtct gagagatggt cagtactttg aaggaaagag aaataaggct ttgtctcctg 122100 cttcttctta tacctctttg cagattaact ctgatgcttt gagtgtctta ctgcattgcc 122160 tgattaaaac ccatcccata atgcctgatg tgatgggaaa caccacttac tctatctcaa 122220 tggaaagcat tcagatgaac tttcaacaga aggacatgct cccgcctctt ccaaacacct 122280 cttttaaaac cgtgtctatg ggcctttctt catgtcttca acaatttgtt taaaactggt 122340 tgtgctaggt agtgggcaat ataaagatga tcacaggaaa gagatgacaa tatcactgat 122400 tccttatagt gctataataa gggtttgtca aggttgtgat agaagtagag aggagaggca 122460 cctgacttca cttgggtgtg gggtttttgc taaggtgctt ctaagttgaa gtgtccttga 122520 gctgaggttt aggggaatga gtagcaaaga tggattaaat gagaagagga taggcggcag 122580 cagggccaga ggtgtgaata gcctggaacc ttctgagaag attcctttgt agacagaaga 122640 aaggggagat ttgtggaaat gctggaagat aaggtaggaa gaggccacat cagatcacac 122700 atggctggct gtacctctct aaaagtttat gatttgtact ggggggtttg aaacagaggc 122760 tataaattgg cagtttaaga aaatcactgt ggtgttagtg ggaagaatag attttggcaa 122820 gattctaact aggattattt tcaaaaattt acgcccagtt tagtccagat gtcagggcta 122880 gtttggagta aatttctttc tttaattact ccagggctct tgtattgctt cagagaaagt 122940 agaaagggga actcaccctc attcagggag ggtaggcgag cgaccagcca gctggggaag 123000 gccaaagagc caggtcacct tgtgcccaca cttgttatga tttgtttgta ctgtctgctg 123060 gatgatcaat gatattagct acgacagcac atatgagccc ggggtaagtg tgtcttcttg 123120 ctacttgaag tgcttcttga aaatagtgac aggctgaaga caacacggaa tactgaaaaa 123180 gcccattgga caggggacag gagacctggt gctgctccca gcttggccag caccagcccc 123240 gggggcttag acacattact tcacctctct gggcttaact tacccattta taacatgcaa 123300 cctttagact aacactgtcc tcggggcctt gttcagcccc tggcttctgt cattgtgatt 123360 ctgcgccccc cagggtcccc ctgggcccca tcactactaa ccctaggctt ctagacatgt 123420 tgattcatag agaaatagga aagccattta tcttcagtga gtgtaagcca gaagtacagt 123480 tgtgtcttaa ggaatctaat ctagtgaaca tggaaaatac ttttctaagg aaaaaaattg 123540 tgattggtgt tctgtcctga gctgatggca aaagggaagc aggaaccact tcatacatct 123600 caatccctct gttttttcct ttctatcctc ttgaattttt cggcctgttc gtctttcaaa 123660 agtggagagg agtttgaatg gggatgctga ggacactgag ggtagccacc tatggaagag 123720 gcttgactgg gaagccgagt tctgccacct gacaaagggg cacgtgttca gtgtttattt 123780 ggcatagcag ctgttcaggt ggagcccagg cagaattttg acgtcgttgg gaccttccat 123840 acctttctga aaatctcttg caccaacacc cggcaccctc aggttatgtt ctgcttccca 123900 aagttcatcc ccaggctcaa cttctaaccc tcttgttttc tcttttacca gaactaactt 123960 ctaaagatcc agagacaaca actagatggt ggtctggatg ttcctgaggt ggaaagagaa 124020 cctctagtgc ctctggctga cattgtatcc actgacaggt cccctcccac atgcatacat 124080 gtaacatgtt tctgctcact tatcaaatac agcccatgct ttgatgattg aggacagagt 124140 ggggattata agttgatgca gtaggtctgt gtcttgccct gagaacttca caaacagcaa 124200 cacaggcacc aagaactcat cactcatctg ttccacccac aggggtttat catcttgtga 124260 cttggatatt gtggaatatt ttatagtaaa ggttaaaaaa aatcagtgta ggcacagagg 124320 agttaacagc tacgttgcag tggggagtat ggaaggcttc atggaggtgg tgatatttga 124380 acgtgacttt gaagggtagg tagagtcctg acttctctga cagtagcctt gaaagtaggg 124440 gaaacttgac catgaagaag gctgttgaaa gtctggagaa cagaaaaggt aggggactaa 124500 gactctagga gaaggtacta cattccagag agaatacaga agtataatcc tccctcatgg 124560 tgacaagtta aatgtgagaa gggatggact aaccaactgg gtgaaccctg atctcattaa 124620 gcaagataag aaatagaaga aatgaatctg catgttcatt atgtagggat cagaagcagg 124680 taggaaatgc cgactttatt ttagacagag gttattttag gtacctgtgg gcatccaggt 124740 gtattatttc cctatgtctg aagcacatgt cctttggttc tttagcattt tgatgatgat 124800 gctacatgta aacttccccc tagggatttt ctgtaagttt tcttcctcat tcgagagtaa 124860 agttttaact ggtaacatga tcacaagtgg ttgaaaagtt aaaatgctag tcatataact 124920 tttcaatgaa gggagcatga atggtttggt actgttttac aagatgtgaa aactgatttc 124980 acttaagtag actgtaacat aaagtgctta tgtgtctgtc cctttgactt tctggtaggt 125040 gtacagtctc tctgaatcaa tagtggctca gacttctgat ttcaaacctc ttcgggcatc 125100 caactggttt gggagaaaca tagccaggtc attgaattat aatttcctga gttatggtgt 125160 ggtggtccca taggacagta aacataagcc tcctgggaac tgaactttta attcaggagg 125220 actgaaaaca agctcttctg agtcaagatt tgcaaggaca tgtgacaaag atagactggc 125280 cttcccgctt ccacaccatc ttttcctcca taaatacgtg ctccttattt ttcttctacc 125340 ctagtctgtt gtagattttg accttggctg ttactttcct accaacacat tgcctgtttt 125400 taagtttcct ggtttgacct gatgttaaga tggaaagcaa ggctagcaaa ctgatggaga 125460 tagagccttc cagcctttct cactttccct gggatcatct catgttgatt tacatgttca 125520 aaaaaatttt ttaaagaaat aaattgtatc agttgctcca gaggtgatta gactctaggg 125580 gcctgatttc tcttagccaa acttaagaca tgggccaata caccaaaatg tcaatatatt 125640 tatttgtttc gtattgcact gtcaagcaat ttcatttcat ctgattattg tgttcatttt 125700 cctgaaagat agtgatccca gaaaacaaga atcagaaggt catttgacaa ctgtggagtt 125760 gaaatagagg gaactaaatg accttagggc atagcatcat caagctttga gaaattattg 125820 tacctgtctc tgtgttggga cattcttttt ggtcccaggt agttggagga gacaaagctg 125880 taaattattt actagttttt caacatttcc ttatcgttta ttgttaactg acggaactat 125940 attgtctctg aagtccctta tgaataaaat tgctagacat tgcaaaaatg tccctctcaa 126000 tattgacatg tttcagtggt gattattatc ttcctgatta atgtttacgg tcaatctcaa 126060 gctctataat ggactcttaa aggctgtagc agttttctat tgcttccata acatattacc 126120 acaaactttg tggcttaaac aatacccatt tattgtctca cagttctata tgtgagaagt 126180 ctgggcacac catggccaaa ctgggctctt gcttagaatt tgcaaggcag aaatcagtgt 126240 tgttaggacc tctagggatg aatttgcttc caagccgatt ccagttgttt tcatgaactg 126300 agttccttgc cattgttgaa ctatattccc ccatttcttt gctggctgtc agctaggagc 126360 cggtttttgc tccttttact cctgtctgca ttgcatctca tggtttctgt gtgccccctt 126420 ccagcaacaa gattctatgt accctcttcc agcaacagaa gatcaagtcc ttttcaagtt 126480 tctaatctct ctgacttccc cttctgccat atctcattct gcttttacag gctcgggtga 126540 ttacatcagt ttatgcaggt aatccaagat aatctcccta ttttaaagcc agtgggttag 126600 ccatcttaat tacatccaca aagttccttc acagcagtac ctagattagt gtttgaataa 126660 cctgggatgg taatcttgca agggatcttt tggcattctg tctatccagt ctcatcagca 126720 acactttgaa atattgtcgt tacttgagtg atcatttctg tgactggctg atttcatcta 126780 tacatgtata ttatttttat ttgccatttt gtagggtaat attttctgat cttaattcca 126840 tatttcagta ttaaaattac ttgacataga tccataaatc atcatctgtt gcaataaagc 126900 acattaattg gttggtagaa tggggagact gatatttctt ttctcttctt cttggatgag 126960 ggcaactttt gggggcagat gagttctgtt gtgacaaaag ttatatagca catttggttt 127020 gcactgaatc agcgattctc aatcctggcc atgctttaga attatacaag aaaaatcttc 127080 aagtatcaat actcagtccc taccctactg atccaattta tctatgataa agccagagca 127140 ttgattttta agttccccag gtgattctaa tatataacca aggctcagaa ctactgatat 127200 gttccaacat tctgttttgg agataaagaa gttgaggctg aggatgagaa cttagtcaca 127260 taaagtccat aactagtgac agacataagt tctgtcctac aaaaaaaaat tgatggttta 127320 attgtatgta gagttcagtg ctcagtaatt atgtacaaag tgagtggttg agaagatctg 127380 gaacacccta cttcttgctt tagtaggaag actatttctt tctatgactt taaaaaatta 127440 tcagaccttg caaaacaact tatgaaggtc tcttctcagc agctttggcc tgccttgtga 127500 gtaataataa acacagatcc attttacact agctaggaag ctggccgcgt ggacttctcc 127560 tactcctctg tgttccagag cttcatggta caatgcagta gccactagcc acatgtagct 127620 attgaacact tgaaatggga ctagtttcga ttgagatgtt tgtgagtgtc aaatgcatac 127680 tagaatcaaa gattcagtat gagaaaaacg gtgcaaaata tctcattaat actttttaca 127740 ttgattacat gatgaaataa tatttgaata tattgagtta aataagatac attattaaaa 127800 ttaatttatc aattttttaa cttttttaat gtagttacta gaaaatttac aactatgtat 127860 gtggctggca tttgtggctc acattatatt tctgttagac agcacttttc tagggagtat 127920 tttctattaa agctattgac aatgaatggt ccaagtccaa gctattatac ctcctttgat 127980 cttgaagagt gaaggggtac attataatct tcctggagat gagacatgat attgatctgc 128040 cctgtgtttg ccatctatct ggcagccagt cagtctggcc aaatagactt ctatttttac 128100 atagaagctt aaaggaggca ggataatgcc ccatgtcatg gagagagcat actgcatagc 128160 tcttaagtaa tgtacccaaa agtagaccag gtgctattgg aggttctaag gcatagcaat 128220 aaatattaca tcccttgagc aatgtaatac agcccttgaa gaaactgcca tgtctttgac 128280 aggccctatg cactgaaaat attatgatgt ctacctctct ttataattca catctaaata 128340 ttactctttt tcttgctccc tgtagtttgt tctgattcac tgctaccctg attgtgtgtt 128400 tagcgtgcct acttcacaat ttaagagtca tgggaaagta aaggcaggcc ttggagagat 128460 caagcacagt tcaaaaccct acccagagat attctgcctg tgtgagcttg ggaggagatt 128520 tacttaacct ctctgagctc ctctaaactt ccattttctc atttgtgaaa tgagcatttc 128580 tcttgcaagg tctgtgtgaa gattgtatga aataagaagg ttcctggcac acttatttgt 128640 tgggtagata ttgtggtgaa catctactct gtggcaagcc catggctaat tgttagaatg 128700 taatcgtgag tgagacacag ctactgcctc cagctaaaag aagagaaaga caaggaacct 128760 agtaacatca ggacatgaat agtcatcaat gaatggcagt tattattaca cagcacagtg 128820 caggatttgg cttataacaa aaatttggaa gggtgttcag gtgagggaat tgagacccat 128880 agtgattaaa tgactacctg tgtcaccagc tcaggcaatg ttgggctggt gccaggttac 128940 gggattgctg actcctcctc cagtaatgct ttccccagga gatcacattg cctcactctt 129000 ggtttcccaa cttgtttgct ttaaaagaat aaccttgcca tgttggactt gataaaagga 129060 aagaggggtt tctcccaatt tttgctccat atgttattcg ggcatgctag taactgtctt 129120 tgaaaaccta cacttctgtt atgttaactc caaagaaggc agcaacacgt gcacttcttt 129180 aagatataaa aagcatttag tatactataa attattatag taatcattgt tagattatat 129240 ctcaccaaga taatgaatgt tttcatttga agacttcact gtatgagaac ttgtctccta 129300 tagcttattt atctcctttt agattaggtg aaacagaatt ttcaaatttg agtctgaaga 129360 aaattccaac atctttaaat tcgtttaagg agcattcccc atggtctata tgatctatca 129420 tagtaattaa aaaatcagat tttagaatga gccacttgta gaaagagaaa aaaagtagaa 129480 aatcaataag aggtttcatt tttcaaattc tgctttggaa aaaattactt ggtagggaca 129540 atagtgtaaa gtaagatata agaagaaata tatcattcaa ataagcggcc atgcagttgg 129600 ttatctcttt catgtaacag tcacatctgc attgtgaatt cattaatgca ccaagtgaat 129660 caagcttagt gagttgacaa acatccacag ggatagttgc ggggaggcat tgcaaagtgc 129720 aatgtgaggt cctagtgaaa cagaatgctt cgttctttga gaaagttcca ctctgaatag 129780 aaaaactatg cataccaaga tcggagtatg gccaagcatt tggctactga aatgcccctt 129840 cttctttcat tcctccataa aggaagagac agagactcag gttcttgtaa ctcagctgcc 129900 ttttttgagt tctcccaaga gacgttctaa cttcaagcca agcatcttgt cactgggatt 129960 tctgtatcta atttttagtt ctagaaatcc atgatttcac aaaacaaatt atctgaacct 130020 aacaacaacc acatagaatt ttcttaaagt agacgaggga ggaattagcc cctaaagtat 130080 ttcctacaca attggaactc cctttagaag atgtgcaatt gcctgtacac ccaagcacaa 130140 atgggctgta ttattgcctt atctaggata tacacacttt acattataat ggtccttccc 130200 tttccctgaa cccgcatatg atgtaagtgc ttgatttagg aatagttaca tattgtgact 130260 ggcgaaaagc acatttgctg attgctctgc cacctgccta gatgtatatt tatatatcat 130320 gaagatatat aatttatctt ttatgataaa ttataataaa agataaagat atgtaatata 130380 tcttgatata taaatgaggg tccctactct cagtataccc cgtaggaaca ttataaaaca 130440 taaatagtct gttgttacta ctaccaagaa gactttagta agtgtaataa ctaacccttt 130500 tggatacatg cagagcgaat gccaaatgct ttaaataaat tatcgcatct aatcctgatt 130560 tttttatgaa aaagggaaaa tcttatcata tcaatattag agatgagtaa gctgaggttt 130620 gatagagcta ggattttaac ttagctctct gtgactccaa agcacattca cttaacccca 130680 acctcaccct ctctgtaaat gaagattaac aatagcatct gtggtagaag ctaatgtctc 130740 ctgatctggg aaagtatctt tcaatgatta ttaactaaat gtgatcagct gccactggat 130800 cagatgtcat caaatgaaat taagtgtcca gggtttactc aacagtactg tctcttacgt 130860 tttgtatcaa tgttagtaga ttgcttaatt tttgtacctg ttacctcaca tgaagcctag 130920 atagcatcag tcccttcccc agccagtgtg tactgggtcc agcttctggc ttgtgaatcc 130980 aatcagtgaa ttaatgttgg tagcttaaaa tcagccttga aagaggtatt tacaccacag 131040 aaattggcaa atgatacaaa tcatgaccct ttttttaaat tccagagaga caagtgttaa 131100 acatttacca gtacaccact gtctgtgact caaataggga cataatgtga ataattatac 131160 ttctgaaggt aaatgaatgc acactgggta cccttgaaaa aaacaacctt ccacagatac 131220 aatcatacct aagtcaccta agtctttagt gaatattttt gtccccatca ttctgctttt 131280 gggaggacct tttacaacat aatcatgatg attttacatg tcttttgaat ttttaaaaaa 131340 ttactttatt tgttcatttt tgttacaaaa gcaaatatgc ccacagtaat catttaatgt 131400 ttttgaatgc aagtgcatac atataaacaa taaaatgtat atatgaatgc tgccagtaga 131460 aataaaatgc aagtcacgta tgtcatttaa aattttcaac tacagtcatg caccacataa 131520 tgacttttca gtcaatgatg gactggcccc ataaaattat aatatcatgt ttctatgata 131580 tcttttctat gtttagatat gtctagatac ataaatactt aatattgtgt taaaattgct 131640 tatggtattc agtagagtag taacctgctg cacaggtctg tagcccagag caataggcta 131700 tcccatatag cctaggtgtg tagtaggtta taccatctag gtttgtgtaa atacactctg 131760 tggtgttcgc agaaccatgg aattgcctaa tgatgcattt ttcagaatgt attcctgtca 131820 ttaagtgata catggctgta atcacattta aaaaaataag aagaaacaga ggattttgtt 131880 ttaataatag atttcattta actcagcagt caaaaatatg atttcaacat gttgtcaaca 131940 taaacattat gaagatgttt tgcatctttt cttcttgtac taagctttca atttcatgta 132000 tattttatac ttatagcaca tatgaatttg gacgctaaat tttaatcata aatacttgat 132060 ctgcatttac atttcataaa atgtaaagct taaaaagtgg gttcatatat ccaacatgtt 132120 ccaaatagac ttacatattt aattaaattt aaattgtcat taaattcctc aattgtgttc 132180 gccacatttt aagtgctcaa tagacacctg tgacttattg taacagaatt ggtcagtgca 132240 ggtatgtacc atatatcctt attttataaa attggagacc taggttggat gtggtggctt 132300 atggctataa tcccagcact ttgggaggcc aagacggaag gatcaagtga ggccaggagt 132360 tagagaccag cctgggcaac atagcaagac gctgttaata aaaaaaaaat agctaggtgg 132420 gttggcacat gcctgtggta caagctattt gggaggctga tgaagacgga tcccttgagc 132480 ccaagagttg gagactgcag tgagctatga ttatgctact gcactcccaa cctgggtggc 132540 agagtgagac ccatgtctct tcaaaaagta aaaatacaaa taatataaca aataaataaa 132600 taaaattgga gacctactat atgtactact cccaaaagtc tttttccccc tcacacctta 132660 cacatttaaa attcccatcc tgcattcccc actggatctc caagaggaga gaaatctcag 132720 caaaagtagt tctatcaaaa ctgtctgtga gctttcctca ttcataggaa ggaaataaat 132780 tcacctaagg cattttagat ctgaccattt tccaaattat catcaccata aaaagttggt 132840 aacaacatga attctgaaag caaactattt caatgcatgc ttggtgctaa tgaaaaccag 132900 cagttttaaa tgcccttttg ggttaacctc ttccttttcc tgtgctgtat tattggaaaa 132960 gcttcagcaa ggagatcgac tagattcaat ttcacaatat ttcttagtaa tcaatgctgg 133020 catttactct tcccatctat taatatatta acatcacact tctaaggatg cgtctaagga 133080 tgctttaatc acttttaaaa aaatacttga tacaaattag agggtgtccg ttattttagg 133140 tggtggtttg ttttatttcc acaaaattac aaaccagata taagcatatt tttccctgtg 133200 tggcttaata aacttttttt ttttttgaga cagagtctca ctctgtcgcc aggctggagt 133260 gcagtggcgc gatctcggct ccctgcaacc tccacctcca tggttcaagc gattctcctg 133320 tctcagtctc ccgagtagct gggactacag gtgcacgcca ccacacccag ctaatttttg 133380 tatttttagt agagacgagg tttcaccatg ttggccagga gggtctcaat ctcttgacct 133440 cgtgatccac ccgcctcagc ctcccaaagt gctgggatta caggcatgaa tcaccatgcc 133500 tggcaaataa acttttaata taattgttga tgaaggtgtt atggagactt gtcaccataa 133560 tagtctagtc ttctccttaa attcacgtga tactcctcat ctctatgtag ctctccctca 133620 ccttcagtaa tgacctccct tgtctctcaa tctttggtct cttaccttca acttcccact 133680 agtcgtttct cacatttcca aaagtcttat aattgcctta aaacaccaag tatctgaagc 133740 agtcctatga ccttctcctc ccgctaacca actcagatcc ccaaatcctg atttctttca 133800 ctagcactat ctctcatcca cacataccca gttatttgtg acagacgtgt ctctaccatc 133860 tctcatatcc aatcatcacc aaatcttgtc aatacttctc agtgatatta agttaagaag 133920 gcatgaaggg cagctgtaac ctaaggaaaa cccacttttg caccaaatct ctagtgactt 133980 tctgatcaat ctgagttgaa aatgctgttt ttttttgttt tttttgtttt tttttttttt 134040 tttgagacag agtctcgctc tgtcgcccag gctggagtgc agtggcgtga tcttggctca 134100 ctgcaagctc cgcctcccgg gttcacgcca ttctcctgcc tcagcctccc gagtagctgg 134160 gactacaggc gcccgccacc tcgcccggct agttttttgt atcttttagt agagacgggg 134220 tttcactgtg tcagccagga tggtctcgat ctcctgacct cgtgatccgc ccgtctcggc 134280 ctcccaaagt gctgggatta caggcttgag ccaccgcgcc cggcctgaaa atgctgtttt 134340 aatctggtcc tacctcacca atctaatttt atgccctttt attcgtaaat ttgaaccttg 134400 ttctctattc actagcttcc tcagaatatc gtccaaaaca tactcagaat tcatactcac 134460 atccagaaca tttgctctga gcttttacca tacaagttga ccatagtttc tctccctttt 134520 ccactcttat ctgtcatcta gttctaattt taagactgtc aattcgatac ctgatttttc 134580 cctagtctga ccttctattt tcagatatgc cccttctttt cacagtttca tgtgtttgta 134640 ctgccttatt cttgaagaac catgattttg attgcttttg cgttaatctc cgtagtgcct 134700 tgctcagtgc tagcaggaac tagtagttta acaaatactt gctaattata aattaaagag 134760 aattaaacat attggtttct ttgtcaggag ttggttatag catgctggaa aatgtattat 134820 atctaaccct catcttttct catgtgttta caaattgttt tatggccaaa gaataagtta 134880 gtatatcatg ggcctaatta tgtgattcgg aggcctcctc tgctgggcag tctacagatt 134940 taaaattcat gccagctgca ttacactggt tttgaacttg ctttttcttg agaaagatgg 135000 gaagcaggca aaatgcctca ggctttcagg gtggaaatgg tgtgagttcc attatgcaag 135060 aatagaagcc cattttttat cccgcctgct gaaaatcttg ccatgagtct atagtcaaag 135120 aatgtgtaag tatcaaaaga aatttagaga gggattttcc ctaggaaaat attgcaagct 135180 taaaaaaccc agggagctaa ggtccaattt agtagattcc tctgaacaat gccatcctct 135240 acttagatta ttatagaacc tcttatgacg gcatttgagt ggactgctgt gtctctgggt 135300 taataggtac aagtaataag tttaggtacc tgggcaaaaa gggtttggtg gaggggaata 135360 gagggacttt ctttttctca catctggcat atcattacat tgtaatgtta gataacatta 135420 aagttccgaa cttcatgtgt cagcactctg acctttccta gggacatttt atctcggcta 135480 gaacctaata aagattccct catctagaag gtgccatgtg gggctctgca aacatggcgt 135540 ggactgctta caatacagtt gaatgtcact tctcatggcc tggctcatgt gaggacccta 135600 gagagagttc tgcagaggag tgcagagggc tacttttgga gtcattccca ctgagccaac 135660 atcagtggaa gagaagggga agagttaggt tctaatcaag cacttagctt ctgctgaatc 135720 catccacatt tctttatcct cctcctggcc cctggtctta gttagagttg ggtccctatg 135780 cggtgttcca ggaagcagta aactgcactc acctcctatt tgggagcatg gcaattttaa 135840 atattatttt ctcctgtagg agtatgcaaa cagatttctg gttaattttg tgttaaggat 135900 tcttgtttgt tttttgtttt gatagagcac attctatgga catatgttca gcttgtaaag 135960 gaagtgttat aattatagtt cctttttttt tttttttttt tggagactga gtcttgctct 136020 gtcgccaggc tggagnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 136080 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 136140 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 136200 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 136260 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 136320 nnnnnnnntt caaaagtttc gggattggag gaaggtcatc aactattcaa ctgaagtaaa 136380 tgccatttat ttgtggcatc tgccaggtat ccttgagatg tctgaagagg tgacttccaa 136440 accagaggat gtggccttct gagaaatgca aacctgttca caccctcgct cagatgggaa 136500 gcaaaaaagg ctgcctggga attggggatt tactgttata ccctgacatc agaatagcag 136560 gtgctactgg aaacttcttt acctgatact aagtgtcttg ggagataaca agtaaaatta 136620 acactgtata cagcatccag ttcctcagtg ttttcttcac ttaaaaagaa tcagctgggc 136680 acggtggctc atacctgtaa tcgcagcact ttgggaggcc aaggcgggtg gatcatttga 136740 ggtcaggagt tagagacaag cctggccaac atggtgaaat cctatctcta ctaaaaatac 136800 aaaaattagc tgggcatggt agcacacacc tatagtccca gcaacttgga agactgaggc 136860 aggagaacca cttaaacctg ggaggcagaa gttgcagtga gccgagatca tgccactgca 136920 ctccaggctg ggcgacagag tgaaacaaaa aaagaaaaaa gaaagaaaga atcaaattca 136980 aagcaaatac ttagttacca acaggattgc atttttagcc tataacatct ttttttagcc 137040 ttttaatatg tttctgctgg aggtttccag ctttgattac atagcctgtt cacctaggag 137100 taaaggacat ggggagggag agatgttcag tggttctcat ttggaaagta gataaggatg 137160 atgcaaggcc atcagctcaa ggccttccag gttaggaatt aaaaacatgg atgttgtaaa 137220 aaccacaact catatttatt tgaaatctca ccattgacaa agtgtgttca cctgcatgtt 137280 tacactcagt cctataaacg actccatgaa gcagtgtatg gaggagagtt cctcatgcat 137340 gtgggtttgc acatggggat tcagatgcaa gaagatactt agtttacata gagatatgtt 137400 ttttatttta tgaatataaa attatatgga acaaaaaaag ataagtcctc tgctgtctag 137460 aaattacagt acatcaagaa ttttatccct atgtagaatt acacagccat tgccagagga 137520 ccacatctgt aggaccatga aaacaaacat ctttgctcat tatttcagcc tgattaggga 137580 taccatgaag ggctattcca ttaggtcagg tttgcacagt aataaaaatg atgccagtag 137640 aggtcctggt ggagctccta gtatgatgat aagtgtctga gtaacttgta aatagtgcaa 137700 ttttatggaa atgttgcagc taagctttaa agtagttggc attagttgtt agacacaaca 137760 acagctctac aaaaggcaat atgctgagtt catttttgac tagcccaaac ttgcctcaaa 137820 agatccggga tgtggacacc ctggtatatt ttttctagaa aagcttattt ccttcctcca 137880 gataaaggtg tatggtcact gaggtgtgta ctgacagatg tgttgatcta ctctctccgt 137940 taaactgaag ggctccaggt gtggccacac tgggcttcta aatgcctagc aaagccacag 138000 atgcatccct cttggtgtct gaggtgttca cattcctggg tctttcagat ctgtattcct 138060 catgaaaata aaaactctct acgatacaat ctgtccttgt gggtttttag ttttactagg 138120 gagtttttgt tttcttttgc ttcccgcctt ctttctgctt cccttctagt taaacctctt 138180 taggatggct cattagcact ttgttttgag tgtgttgagc tgttttgttc actgggaaac 138240 agatttatga aatgttacta ttaccgtgat tgttctgttt ttccttttat ggcctgtcca 138300 gctcaaggcc ccatgcttgc tgatactgct gataaggttt tctatttcca gatcaaattg 138360 aagcaaacct tactggccct gttactgaag ctgtgcatgg gggtcatttg ctgtgaggtg 138420 tttctatggc tttgagccag gatgtgaaca tctctagtgt tcatgttgtt tcctgagacg 138480 agtactcacg ggcagtagaa tttattacaa cctgctgttt gagttcatga aaagtaggac 138540 aatatgagac tcggggcaat gaaagactta ctaggattcc ttctggaact gattcatcag 138600 cacattcatg tcttacccag tctttaaaca gtatttcatg ataatggtct gcttttattt 138660 gctgggcttt accttactct ttttgtgatt gcaggtccta caggtatgga tctctggcag 138720 ctgctgttga ccttggcact ggcaggatca agtgatgctt tttctggaag tgagcgtgag 138780 ttctgctttt ccatttccac cctcagtggt ttgaaacaac actgaattgt atttgttata 138840 tccaagtttt gtggatgatt ttattaaaag atgcaagttt tacatagcag caaataggaa 138900 acttgactta actttaaaat cagaaactag taggactttt ccgtggatgt ttaggaggaa 138960 cgcagtagtc agtcaacttt ggcatctggt gttttcatgt caaaaattaa tgctacaaat 139020 catgctgagg acatttatgt tgaagaaaag ccaggtctct tgttctcagg ctctgggaga 139080 aatattgaag ttacactgaa gagttattag cttactgttc actcagttca tttgtgacta 139140 aggatatcta gtctatttcc agagctcaga attcaggctt gttaatcata ttctctgaga 139200 aaggaaattg caggtttcaa atgaatttca cctctcactc tctgggtgat taccatttgg 139260 ctaagttgag ggaagagaca cctgaaatag ttgaatgata tacccagaaa ttatgagctt 139320 ccttccccat ctctataatt ctccctccct tttttatatc cctctcctgg tagagaagtc 139380 tcaatatgta taaactatgt ttcatagcag acctaactaa aacaaggaag agtaatggaa 139440 gggaaagtgg agaagaattt ttctgtcaga aagaaaactg tgctctctaa agggtggtgg 139500 gagacctttt tttttttttt tttttttttt tttttttttt tttaatgagt acttgatact 139560 tttccttgcc tgtgcttcta cagaagaaag aaacaatgta tttctcccat gctatgacac 139620 tgaatttagt tgttacttta ggagtgtctg actccccttc tcaccattca gctcatgttg 139680 gaaaatacag tttaacagca gacttagcgc cttaagatgt cctccctgac cttctagcca 139740 aaaataaatc cgtagtagtg agctgctgag ggtgaccaga gtcacttaga aaacgagaag 139800 agtaaaagat gttattttat ctcttaaagc aatttaaaaa tatttataga aaagagtcat 139860 aattgtttga aatatttttt ggtctctctg gtgttataat gtcaacatta tgcaagtcaa 139920 acatggagag aattgcaggc tccgtttcag cagcttttcc catggctggt tttagaccct 139980 ggttctgagc caaaaaattg cagctgagat cctctgctgt tccaaagtca tggtggctta 140040 atctctcgtt tcttcattaa ggtgactttc actctactgg gcaagatttg aggaatttaa 140100 aaaacttgtg aaatgaaaag tatggcatag gaaatcttta aagaaaattt aaaatgcatc 140160 cccagctgag agattagagc tcaaattaca ttttagagct agaaagtctg cacggagcat 140220 ctgtttccac tgcttcgaca ttttactaaa cctttgagtt cctgagtgaa gagaaaacat 140280 cattagttgc ttttaatgct tgattttttt ctttttaata gttttgtttg attcatttat 140340 ttgtttaggg agagcagaat ataagcaaat gcagtggttt atactaaaca caaatcacat 140400 atcctaccag tggttacaca taggaagtaa tttaacaaag aagaacattt ttgtctcctt 140460 tttttttttt tttttttttg tcttgttgag ctaaccaata tttctttttc ctttggaata 140520 tgtgcatatt ccagaatcct ttcttaaaat gatctaaaga ttaaggatgg ggtatgatgt 140580 ttatgtaaga aggcatatgt aagctcattc cagcatgtgt gtgcatgctt gcctctgtgt 140640 gtgtgtgtgt attctagttc tggccactta tctaaggggt tcttgggttc agccaaagtt 140700 actgcataac atgacacggg tcagtctcag atgacattta tgggccatgt gtttgttttt 140760 ctgccaggtc tggattgtag ccaaatcnnn nnnnnnnnnn nnnnnnngta gacgatgaca 140820 gacctctatg catagggaag ggtggcactt gagcagggat tttcttgtgg gcagatgagc 140880 aattagaaat atactggccc tgaaaggatt tttttaaatt aaatctaatt gccctgtggg 140940 aaatttaatg agaactaaat ttgaatagtg ccattattgt gctagctaaa gtgttgtaat 141000 agatattttc tgtctctcat ccttaacatg aagctctcat ccttaatatg aagctctatg 141060 tctgctcctc aagccaatta catagtcttg aggagaattt tttattccaa aatcaggaat 141120 gatccacaat gccttgtttt caaagggctt cacatggttg acctgtcaac tgattgtatc 141180 aaaattgctg ctgctggaat gatgttgcta gtgagaaatg tgcataaaga tctgatggat 141240 aaaagtattc ttccaaggag tgcctgttat aaattaggtc gtatatctct actatttcag 141300 tcagtcctcc cctgaatata ccctttgacc tcagtaacct aaggtggaag taggcaagcc 141360 cctgtcttgt agttcagtct agctaggaca tgaggaatgt cttgaaatta atgagagact 141420 gtatatcttt aaggtttaga ttgtgtgatg aagagaaatg gtcaagatgc cctgaaaaag 141480 aatagatcaa ggtggactag aatagttaat tcaacaaatt caatgtactg ataattctta 141540 agagtttcct attttcaaag cctgcaccta cggctatgag gaatacattg attcttccct 141600 caaggaactt ttcatgtgtt aatagatcag gcatgtacac caagaattac aatatcaggc 141660 attgtatatt aactatcaaa atggcttgaa tcacacttta tagaagtgat gatgttggga 141720 gggatacctc agctgtggtg aattacagct tcatgaagga ggctggcatt gtttcaatag 141780 agactagaat gtcgggttta agattttaaa aggctgagaa gaacagaagg ctattacagg 141840 aataacttat gcaataaagc aacaacataa acagaagtgt acaaatgtag atatgagatg 141900 tccatggaga acacttcatt cacttactga gtgtttttta tatatatata catacacaca 141960 cacacatata tatatatggc actgtctagt cgatggatgg ttctgtttta gcatttaaca 142020 ttcaacgaat atttcttgag cacttacttc atggaaggca taggattaat ttggccaggg 142080 tgtgtggtac ataggtgcta tatttgtaat tattcccctt ggaagcaaac ttaggtcagt 142140 aggtttgagt caaattatag aaggcctaga gatagcaaag gcattatgga aaaggcaaga 142200 cttgctgggc ccttgaagaa tcagtagcat ttggagagga agaaaagaaa gaggaattgt 142260 atgccatatc cagcaagtaa taggcctcaa tgttggaggc cagagaaaac tgctacctgc 142320 aagatggaat agtttgtatg tgtgatattt atatgtaaca tatataatac ctatgtataa 142380 tattgatata tatttacata taacatattt atatttgtat gtgtgtaata catacactat 142440 atatgtacat atatacatat atatgtgtat atatgtacaa tatatgtata tagtatatat 142500 atatatgcat gccagttagg tgtggcttat aggcaaagca cataattgac atcactcaaa 142560 ttctgcaaaa gttgttatat cattctacac ccttcaaggt aagagactta ggaatgaggt 142620 gccacatcct aagggaaccg agagccccat aatgttttct gtatattttg aacatttttc 142680 ataaacctat gcacactgac aaaacactta cttgaaagaa aagacactcc tgttctcatt 142740 gctatcagat aggaaataat ggcacagtgg acaaaacaat ttatttttta aaataaactc 142800 tgtcccacta caggtgaagt tccacagagc cctgagagga tgttaagaca tgtcggatat 142860 atttcataca agtattcgag tcatggtttc agttagtaaa cagtaatgaa tgcatctgtt 142920 aaatgtgttc aagaatgaac aattcaaggc tttccattca cagtgaagat ggggagaaaa 142980 gccacagagc ttttgattgc tgctgtcttg accatcatcc agaggcaaga agaaatctta 143040 tggtgtgttc tagtgctatg gcctgtgtcc atgtacatca gcaatcctct gaccccttgt 143100 cctcctgata ttgcagactt tatttgatgt tggagttcag caggtcacag caagctgggt 143160 taatctagat ggtgccaatg tagataatga cacaaaaaaa gtctttcaag aagcttttat 143220 taagtcattt tacagattca aggaggaatt ttatgtatgt atttatttat tcattcatgc 143280 atgcatgcat gcatttattc atctttttct tttagagata ggaactcgct atgttgtaca 143340 ggccccaaac agttctacta gcttcacaca atctttcttc agtctgtaga gtagctggca 143400 ttataggtat gagccactgt gcccagtcca aggaagaatt ttgaatgtat attcctgcct 143460 ttaaggagct cacagtcttt agaagagaaa acagagaaat aaacataatt taattgtgat 143520 cctcgtaggt tattaaaggg ttttaatcta ggtaataata ctgttagatt tttactttgt 143580 caataatact actaatagga tgaaagtaaa ttcaaaaggg atgaattaga ggaggaaggt 143640 gatgacaata ggtcaggaga gagataatct aagtgtggca ggggtgataa aaaatagatg 143700 gatcaccaac acagggatgt tagaaagaca gagttaccag tactcagagt ccaattaacc 143760 tgtggatatt tgacttgggg aactatcagt gccttctttt ccatccgttt ctaagtttct 143820 gcatttttaa ttaatgtgat catcagcaat gactcacgtt taatgcagtg aagtcctggt 143880 gcacagttca gcctattagc actaaagtgg tacttgcaca gaacagctct gtaggggagg 143940 aaacacgctg aggctggatg acagcagagt gtctaagcta cgcttctttt gtaccatttc 144000 tctgaactcc tcatgcctgt gtctaccctg ggtcccacag ctctctgctc agctctgcag 144060 tatggctgtg atatagctca ggctactatg cagtgagggt ctacagcaag gacaaaggtc 144120 tgaactccct cctcattgta gtctctggac atttgtgact ctatcccgag accttgacaa 144180 ccccccaagt attttatcat tgctagagta tgtacttaac tcatgggatg caataaaata 144240 tatgcaggat gagttgagaa cagcaaagcc atgtgctggg cagagtctgg gaggttggtt 144300 aggctcccac agaaactgag tgactcacct ctacaaagaa gctggcagtg tgagtgatta 144360 gatttatgcc acagctaatt agtaaattga aggagtggga ccacccaaga atacttagaa 144420 ccctgactgt tagttaaatt cacacatgcc agtgatcgaa tatatttctg gtcttccaca 144480 ttagatgcca gctcttatgg gaccagagcc agtcctggtt atataataga atgtttccac 144540 accagtttgg ttcagtatcc taaattgggg ctcttgttat ggggtagaga ggaatgaggt 144600 cgacataatg tatttggtgt ttggtgatgg caaagagtac ctgttcatag acacacctgg 144660 ttgttcacct ctggctagag accaacccaa gttcaactgt agagaagtcc attttggtct 144720 ttactggccc agccagcctc tacatgagat cattccctac aacaaggggc ccaggattcc 144780 tcagtcaccc cagcaccttt tcctgaggaa aaccatctca tgaagaactt gccactgatg 144840 attttctcct acctgtgcat tgaagtcagt gggtttctaa ctgagaactg gttcctttta 144900 aaccttctta accttacact gtatatgata taaaactgta ggcagttcag agtcaccaat 144960 aaagacatct tttggggtct ctacttggct tgtaaccacc tgcttatcca cagtattatg 145020 cacctagctt gtcatcaggc agagtcacca gcagccacaa cacaagggtc caccttcatc 145080 tttccgaagc agcaggcagt gtcactccat tttgactttt ctggcaatac tcacacggat 145140 tgttaaataa tgctgtcaac agtgtcatct tcaaacccaa agcaaagctt cctcatcatc 145200 tgtagttagc agcataaaga cggtgatgat gtgtaacata aacacacttt gaaatctgat 145260 gcaattgacc ctacgaagag agtattcctt agtgccctgt ctggcaactc ctggagagac 145320 caagaggcct tgggccttag agcacttctt cagcctcagc tgcaaatcca ttttttctag 145380 ttccttgttc ccaggatgaa gccacagtgt ttcatcagat acatctatca ggaatctctg 145440 tttctgtcta tataacaatt taacttaagc ctcaacctgc acagtgtatg catcacattt 145500 ccatggaagg attgcaggta ttagaagatg atggatcatg tcttgaccac aggggaaatg 145560 tttcaggatg tttttataga ggctttcact aacaagcagg acatgggatt ggcagagagg 145620 tgggggtagg aggcaggtga agggtggcat ttgttgtgtg tccctcttct aaatgaagtt 145680 ataatgacat ctgtgtttca agcgtgtgga aagtttggat tgagcttgaa ataaatacaa 145740 tttaattggt ttcaaataac tgaacaaaat gaccattcca tgccctgtgt aataaaatgt 145800 tatggaatta aaactaacta gatgttaaaa tccatgaagg atattttgct tgatgcccat 145860 ccttcagcat tctgatgagg atcttcattt atttgttgaa ttaataagtg aatcagcatc 145920 taaatcctga cctttgattt cctcagttct ctcctgcaat tgtcactgat gctctcatct 145980 ccagtcctga gcaaggcagg agttgaatta gtatcccctt atagtgggag gggtctagaa 146040 atagctgtgc cactttagaa gctaggcttt gtgggctttt cctggtgatg gaatgatttt 146100 attttcctgc tttatactcc agttaccacc aagatcagaa ttctgcccta aacactaatg 146160 tgtgagagcc tgatgtcctt cctaagtctt gtcaacctct ttccaggtga ctgaactccg 146220 aaccccatgc accagtcacc aacattctgc attaagtgac ccggtcaccc agcaccatcc 146280 ccctgacacc acctttatct ctacaccacc tacctgatta aatctcctca aatattgaca 146340 gacataatga tgcctgaaga tcccaaatcc aaattttctt tgcccctttg gacattgaac 146400 tttagattac aaaagaccct gactagggat cctgtggata gctgagtcaa ttttcttagc 146460 cccattcctt aaatatcaag tctttctaat tttccaatga gagcacatct tgaagtatga 146520 cactctcaag ttaaaagtca atttatatta ataaaatcct taatttcttg atttctgaat 146580 ttgaaaaaat gacactttgt gtatctttta tttttctggc aaaaccttcc aaatttgtgg 146640 aaggagaaat aatattgact actggataac catgtgctat gtgtaaatat taacagattt 146700 gccttagtgg acactgaatt gatgatgttt gccacattat attttacaga gccttggctc 146760 ttccaaaaat gagaggtcat ttttcagggg aggaccattt tgtgtttggc taacatttag 146820 gacatataat ttcttctcct ctacgtgcca ctgacccact gcatccctgg ttggagcaag 146880 aagagccatg ctttccttaa taattgctga tggtgaaacg atgtattgta ataagagcag 146940 aggaataggg aaacaggaga aagatagtca gttgaagagt cctgccctgt gtcagggcac 147000 cgtttggcca gctgggcttg ctaggactaa aatatagaaa gtacatgaag cttcatactc 147060 agacagctct ggctacgttg aaaactggta tatcatggtg cccagctttc tttgttagct 147120 gggccagcat cataccctct agtatttgct ctgaacttca taagcatggt tgactagctt 147180 tctcttcctc tgcagttgtt attcagactg aatagtttct aagaaggctt ttattgagaa 147240 atagaaggag gtaagttaac ttctgtgcat atcttggcca tatttgcttg agaaactgat 147300 gtgtatacta tagccattat gggtgtgaaa ggcaaaagta taagtgctct ccagtatgac 147360 ctggctgtct tgtcttactt ctatatttga ttgctaaaaa tatatattct taggtcaaaa 147420 aactcacttt aagggaaaaa ataaaagaat attaataacc aaaatagaag aatattaaga 147480 actttaacat gagacgtatt tagattaaaa ccatctcttt ttggattttg gggggtgatt 147540 tctctgtttg ggactgggtt gctattcacc caaaggtgga aacttttgat gttggggaat 147600 gccactgatg ccttaaagca gaggataaaa ggaaaagact gaaattccag gctaaaagag 147660 gagagtgtgg ccacttagcc acaagttagc attcaataaa tactgtataa attagagata 147720 tatttctgca gttggttgat agaagcttac tatgatctgc ctcaggatgc atcaaattcc 147780 tctggtactt tgatcctatt attgactgtc acttccttgg gggcagcagt taatcaagca 147840 gaggcttatc ctgtcagaga gtaaagggag ctatgaagga gctcgctggg aggaaaaact 147900 ggtcctcaga gatgcttagg gtttaggacc agtaagaggc agtctccaca ccacccacat 147960 ctgattcctg tttccttctt ctctgctgtg gtccggagaa acagtttaga ttaggtattt 148020 cagagcagtg gtgttggact ttgtcaaaac tgcatttgaa tcccatatat gaattgtgtg 148080 actttttaaa ggttgagttc cccagaagta ggatgctgag gcaaggattc ctatgaaagt 148140 gaattattag aaaatggtcc agggagaaag cgataggaga gtaggaaatg agactgggaa 148200 ggtaaagaaa ccatcctcag gaggatgcga atttctacac gctatcagtt gtccaagtgc 148260 aggtaaaact ggctccagca gcctgagagc agccgacaca gagacacagg accagagtgc 148320 gggattgaaa ccacacatga agcctgtgtg caaaaaaaaa aaaaaaaaaa aaaaaaaaag 148380 gtaaagaggg gctgggcgcg gtggctcaca cctgtaatcc cagcactttg gtaggccgag 148440 gcaggtggat cacgaggtca ggagttcgag accagcctgc acaacatgat gaaaccccat 148500 ctctactaag aatacaaaaa ttagctgggc agggtgtcgg gtgcctgtag tcctagctgc 148560 tggggaggct gaggcagggg aattgcttga acccaggagg cagaggttgc agtgagctga 148620 ggtggtgcca ctgcactcca gcctggtcaa cagagcaaga ctctgtcttg gaaaataaat 148680 aaaataaaat aaaataaaat aagacaaaat aaataaaata aaataataaa ataaagtaaa 148740 ataggcaaag agatgaatct acatcaccaa agcactgaca gcatctgcta cagtgacttt 148800 ggtagtttct tacattctct gagcctcagt tttcttatct gttaagtcag aggaaaatga 148860 cttatttaaa aaggcttcag tgaggtaaca caagtaaagc acctattgag attagtacac 148920 aggaaaagca gttactgaat acaattagtc agttggtaat tggtaataat tatgtataat 148980 tcctataatt ataggaagct ctatataatt attctatata attcctataa ttggaattac 149040 caataggcta attgtgttta gtaactactg ttattgtcct caagttgagt tattattgca 149100 aaccctgagg cctaaataaa catgcaaaat aaactgactt gtggaatttt atttataaca 149160 atatatgtat gcctaaaaga agtggttcat ttgcacaagg aagttttaga agctacagat 149220 aattttaata atgactacag aaaactatct tgaagatgtt tctaatgttt aagacatgat 149280 agcataaacc tttataaaac ggaatactgt tctatagtta tagttgtaag aatcagtgtt 149340 tagaggatgg ctttgatgaa attgtactgc tctagttcct gtgcttctaa taaaattaaa 149400 tctgattaat acagcaagta ggtctttggt aagttgattc tgatgctggg agtgattttc 149460 ttaattcttg ctcagaaagc catccatgag aattaaatga gatagcatgt acaatacctg 149520 gtatagttac tggtaagagg tttttagtaa aggtcagtct cctctttgtt taccttctca 149580 tcaagagagg aagaacaagg aaaattaggt tgcttttttg agaaaatgct ttatgccaat 149640 tacaattatc tgaaagtaga ataaatttct aggttaggca agactagagt taaaacgtgg 149700 gtgtgcagag ctgacctgcc agggtactct atacggaagt acatggaaat gtatgtgcaa 149760 atacagtttc atataattgt tttgatcata cacagtttcc acatcagatt atatttgaat 149820 gactaattca gcaaatataa aaaaggcaga aaaccagtgg acaagatgat tcctaaggtt 149880 cctttcttcc tggtctatgc cctagtgtat tatttgaatt gatattcggt ggaacacaga 149940 gttactgctg gagattgagt tataaaaaga ttcaaatggg ttactccatt atatctactt 150000 aggaaatctt tttttaaaat aactgataga tgttcagttt gagaagcaaa aggtatttct 150060 ggccatccct ttatagttgt gtacatgact gcagagccat catttcatgc ttacttcccc 150120 acattcatgt accattttct caaaggaaaa tgattgaatt aacttgctag ttttgattct 150180 ggggtttgtt ttaagcaact gatatttaaa tccacctagt cctctttagc tgttctccta 150240 gaaactttaa tattaagaaa cagctgaact tacacatttt gtaaaagagt tcagacaatg 150300 aattccttct tcttgaaatg catagaagta cccaggtgct agctataccc aagagccttt 150360 tctaaataca aaaaggattg acaaaccaag cattcatcct ggctgggtcc aacagttagg 150420 aatcaaacca tgaacttgct attcctctgt ttgtggttaa cttgtttgta tatttttgag 150480 gaagatgatt caatgcaaga agtagtttta tatagtacat taagtaaatt tcctatagga 150540 tatacttaat cagaaaaata tttttggact agagctcaca gaacatatgt ttacaatagt 150600 tttcagaaag tgaggggcta aatgaggatt tctcaacctt ggcactattg agattttagg 150660 ttagataatt tttctatggt gggaggtgtg tcctgtgcat tgtagcaaat ttatcagcat 150720 ttgtgacctc atacccacta gataccagta gcccccttct cagttgcaac aaccaaaaca 150780 actatagaca ttgcaaagtg tcctctaggg atcaaaatgg ctcctgcttg agaaccacag 150840 tctagatctg gtagttgcat attgaactga cagtccccag aattgttgtg gggatcaaat 150900 tagataaaac tcgtttatgc tttttaaaaa gtaaaacaaa tacatatagt tacattatac 150960 ctcttctttt catttgttag tcatctaaga ttttttgagc ccgatgatgg aacccataaa 151020 taaattaacc ttaagaggct caaaggtttg ccaggtaaac aaagaggtta gaagaaaaag 151080 agagatcata tcagatgtgc cttaatgaat gtctgtatgt aacacgtaca aaaagttatg 151140 ggaaccccaa gaaaggaaag gctctttttg aatgaaatca gagaaaacca actggaccac 151200 acagttgaag ctccataata agaattacca agtaactaat tgtaactaaa tactctttca 151260 tacaatgtca tatatccatg cagtttttaa atctagaagt agttaaggtt catgattatc 151320 atttctcagg gacactacta aagtggtatc aaatctaaat gagcaaatta agaactgaag 151380 ttgttacaga cagctgttaa ttcccttttt catacctgct ccaatgatag ccaacaatca 151440 aacaaaaata gtaaaataaa aacgaaagca aaaaatccaa ctcagatttc actaagtaca 151500 gcaataaata tcagagacat tagggaataa taataggtca aagcagaaat tcattcctca 151560 gtatgttctt caagtggaaa aattaggtct gttttagttc tgttgattct aaaagaaaca 151620 ctcagactat caagaaaacc tgttttaaac tctaaatctg acactgtaga tagatagata 151680 gatagataga tagatagata gatagataga tagatagata gatagacaga tagatagata 151740 gatagaattc tgcctaagta attatctgct ggtaccaaag agattgacga agagattcac 151800 taacctacca gaatttccca accttgttcc gggttattct acattaaata ttcattaaca 151860 aggaaattcc acataaaagc tggtgtgctt gatggagcca tatttacatg aaaggttgca 151920 gcaatttctt ctttaaacct cctctacaat ttgaccaatt ccatgttcca gggagtactc 151980 agaggttgat taggacatga tttgttagct tagcgtgtgc tgtactaatg gttatgagtc 152040 acatttgttt tggaagatca cccttaaagc ctgtcactca tgcttgttta tgggaaacgc 152100 aacaacttaa acatcagcta acaaatcccc atgaatgcat ggtcatattt gagtgcttct 152160 aacaaatgct tcctttcatt tctcccttga cagccctaag aattaaagac tagtggagca 152220 aactgggaga catccatgaa catttattaa aggaagcata ggagagtgtg ataactgcaa 152280 agccagctgt tgatattaat attattggtg tgagattaaa tttcatcagt cttaaaacct 152340 actttttacc accagaaaaa tcaatctgcc atatttaagg ttacattaat gtggaacatt 152400 ccacatactg aactgtcaca tgcctttaaa ataaccatgc cttgctgggt tttttttttt 152460 tttttttttt ttaatcatta caagtgaaac aaacagctga caggtggaga tctattggta 152520 tattcaagtt tttcatgtga aaatatcccc caacattatt tgtaatccca acttgattat 152580 gagaaacaaa cataccatat acaggcagaa gtatgtatca gtagccttta tatttggcac 152640 ctcactataa aatccatatt atgtttcagt gaacatattt atgtcttata cctgagtttc 152700 tggttgcctt cagctttcct cacttgaaaa aaactatact taaaaaacta taatttaata 152760 ttaaagttaa ttaacacagc aaatatttat tgaggaccta ttatctaccg ggtactattc 152820 tcagtgcttg caatgcctca atgaacaaaa gagataaaaa cctctacggt catgctgctt 152880 tctttagtga gatatgtgtg tgtttgtgga gtggaggaca tgcatatgag gcagacaata 152940 gactacaaaa ataatatatt atctagtatt ttataagaca gaaagagcta tggaaaactg 153000 ccccatttgt tcctcatctg agtataccca aaagttgatc ttgaatattt catatgaatc 153060 tcctaggttc taaatgttag aaactaatta aaaataattt gaaactaaac taaatatctt 153120 tgtgatctct ctggctagaa gcctcaggac cagccctcac tgtttactga tgaggaagct 153180 gaggcccaga gaattaaatg atgtagccaa gatttcaagc acttactgtc agaggtagga 153240 ccaagacata caaccttctt ctctggtgtg cttttctcaa ttggttaaca tttaacagca 153300 agtgctttgg ttgataaaat ttatttgaaa atctgtttga aacaggacaa aataagaaat 153360 acctgcttat tccctcactg cagagttgtc atcagcagaa agaagatttt gaagtgtatg 153420 aattatgttc agacaagacc cttataaaat cactctcctc tctccagtgg cagaagtgtg 153480 gcccctgact cctcacccat cctcattcat ctttcatatt tcttgaaaat caccactgag 153540 tattttcctt ctgcttcctg cagcaccagc agaaaagatg aggatgggtc tcttgattgc 153600 catcacaaat ctctttctta ttcttgcttc cattcttatt ctgcacatat cttggacttg 153660 gccatcattc ttagagctcc actaaattat ttgattaaaa gattgtttat aagtccagag 153720 ttagaacgga attgaaaagg cactgcacat tatgatggag aggaataaac tccagtcaaa 153780 agtcatggct tctggactca ccaccctaag gcagcctcac tggaacttgg ttttccaaat 153840 gtcagtgggg ttttagaatt ttcctacttg caagcttgtt gtgaggatta aacggttgag 153900 agagattgtg tctgttatgg aattgtgaaa actgtaagtt gcagtccaca ctataaaaat 153960 cttagttacc tctgtccttt ctctaaagac aggttgctag tggaatagac aagtttgcca 154020 ttattttgaa ggttgtatta cgcacatatt atgttagtga agttggtcgt ctaaaagttg 154080 gaagggacct cagaggtcct atattagacc aactgcggtt attccttaga ataagctggg 154140 agttttctga aaaatacaaa ttctgaagcc tcatacatag agattctgat gtggaagatc 154200 tggaattgat ggcagcagct gcccatctgg agctgctgct gtgaagatgc cagctatagt 154260 gggggaggtg cggctggggc tgtgccctcc acagagtgcc aggtgggaaa cctgccccct 154320 tctgagttgg caggtctgaa gcccagtgct cttcaggcac ggttgcagct gcccatctat 154380 ggctccagac ctgggcatcc ctgcgctctc gggagcgcag gaagcacccc ctgctcctgc 154440 aggcttggaa gtgcctgctg tcactccctg gcctctccct gctcctgcac ccagcacccg 154500 ctctggagtg aagcaaagtc gtggccaagc ctggatgctg tcatgacctg gacaggtgtg 154560 cacacactcg gggcagtgct gacacaccag tcccctggca cattagcact ctctggactt 154620 tggacaccag ccagcatggg agggagactg agggggcact gaggggtggt tcagtgcagg 154680 cctgcaggcg ttccttggca tgaacagcct gggtgatgtg gatgacatgt agatggtggc 154740 aggaagcaga caggctcctg ggcagaaaga ggccagtccc cagtgaagct ccaccttcaa 154800 gccagggatg gccggaagct gggtggccga gctatcagtt ccaggtggag tccttggcct 154860 agagtgagaa cttgtgcttt ttccaggtct gcccatagcc acccatggac caataagcac 154920 acacttcctc ccttctgatc tcataaaatc cctggactta ttgagactca ggcagatgtc 154980 gggatgacct gcctatggat aggagctacc cactttaggt ctcctgagaa ctgtactgtc 155040 actcagtaaa gtacttcttc accttactca ccttccagtt gtctgcgtat ctcattcttc 155100 ctggatgtgg gacaagaact caggacccac ttaatagcag gactgaaaga actgtaacac 155160 aaacagggct gagacatgcc ttccctgccc accacattgt gggtgacaag aagagaagaa 155220 ctgcagccct ttggggagcc cagacctgtg tgacaccctc tttgggggct ctgcggtttc 155280 tggcatctcc aagctcccag gcctcatcac attcccctcg tccagatgca gtcgcccaca 155340 gtggaagcca tttgtggtgt atcagatgca gccgcaggct tgcatggagc tggtgcctgt 155400 gctggtgcct ggagctgctc catgcaattg caccttgata attgctattg ccaagcatcg 155460 acagccccac catggcagct ggtgtacctg gctgtacaca gtggccggac cccatgctta 155520 cccactcacg catccctcat tgctcctcac ctggcttgcc cttggcaggc atagggtcca 155580 ggctggtagc acaaaccaag catagcctac caggccattg gcagaacaag cccagtgggc 155640 ccaagaaaaa cttggtcaaa ggtgctacca gccacagaaa ggaaacacaa aggtttctgg 155700 ctggaaaagc aacacctgaa gaatcctgca acagaatgat gctctggagt gttttctgtg 155760 ttaggtgtgc ttgtttgttt gacaaaagct ccaaacgtga gtctgaagat tagccagttt 155820 gggaagcctt gcttcagctt tctactgaca ttaaactcct tctcctctcc catttctgtc 155880 ttcacttaga aatggaaacc cactaattac tcaaaatctc accttttcca ttcagtcacc 155940 taggcccttg caccctcatt actttgcctt ccaccttgac aattgctatt gccaagcatc 156000 gacattaatc tattttgaca tcttctttcc acctgctgcc ctctagtgga agtgcgacaa 156060 gcagcaaaat atttaactgg gaacagcagg gaagtgacca gtttgagctg gccagttcac 156120 acaagtcagc gcaggtcccc agcatgatgt ctacagacca tggctatgcc agaaatcgtt 156180 aagatggcct caagctgttt ggacgctatt tgcacacaag ttacatttag agcagaactt 156240 tgtaaagacc ctggcatttg ttcatgggct ttttaaaggt ttcaaaaatc tatctggaaa 156300 agattacctt tgggatattt ttgtttcttt gtccctcatt ttcttctttt gtcatttacc 156360 caaattcttc ttcttgcaaa agaaggtggt cctttcctgc cttccctgac ctttgaattg 156420 tccaaatctt gcaaaaaata aagatatata tatatttttt ttaaaaaaaa ttcttccagt 156480 ttagaacctt ccagtcacca ggtgaaaggt attcacatga actgaacatt gacaatgtaa 156540 aggacactgt attctcctag cattcctcca ggtctctttg aggtccgtta gtagtcttct 156600 tttttccagg aggcattgaa gttaagagag tttaagaaga ttgtagtatg tcacaaaaca 156660 agtggaaaag ctagcactag gtctggctga tggaaaatcc ttacgtattt ttttaatgtg 156720 cttgtttggt gtttagcaca ttttttaatg tgcttgtttg gtgtttgatt atttagtctt 156780 ctatgaagta ataaataata acttccatgg taaatgttat taaggctcat ggtactatat 156840 agcaaaaatc attcagcttt tttttaatga atgtttaata atcagtgtgt ctctgcataa 156900 tctccaatta ctccttttag cagaggaaca tggcagggat gggggtaagt ttgggtagga 156960 ggaaaagaca gcaaaagcca cagcactgaa gcaaagttga gaccagattt cacaaggcag 157020 atgccatata ctccctcaag ctttgaagaa actaaatagt tatctatgct aaccaacagg 157080 gtaggactcg tactccaaaa actgatgtaa accgtgtgtg tgtgttgtgt gtgtatgtgt 157140 gtgtcttttc tgcacaatta ttaacccttt ttgtgtagtg gtttttcata gttttatcct 157200 tgattgttaa tatcatggta agtgatttgt tataaatata tttttcctta agtatcataa 157260 acaatgtaag atttcatttg gctgattttt cttttcttaa tattgcatat cattattgtt 157320 agaatacgca tacagattat tcaacttctt aactagaatg tacacacaca tgtgcacgta 157380 cagaactgcc ttccatctct ttgatggtag aaaatatagc tctctatagt aagaaaattt 157440 actttgagtc tcagacatac cctttattct ctgcatgact gctcggaaag agtaatactt 157500 aggatctgga ttccagttcc ctctcctctg accattttaa aacgttgtta ccttggccag 157560 gtaaatacac ttctatgaac ttcaatcgtg cctcaattga gcaggctagt ccaaggctag 157620 tccttggact agttcagcta taggagctga accttgattt gtggcatagt tgaagcccct 157680 gaatagtcag atgaaaatca tattaattaa aattaaatag ttattggttg gatctggttt 157740 ttcactggcc tgcatgaatg atgttttgcc ttcctttctg atactcagct cagaggcttt 157800 cttcaattgg gttttctttc ttgtagtttc tctggttcat gaatagccta tagacaaaca 157860 ctatacggtt acaggtaaaa ggaccctaga ctaagtcttt tattaaacaa atagtcctgt 157920 gtaaataatg acatcttatt ttatgtgtgt gagttttagt tttagggtgt agggcatgtc 157980 tgacatagct aaaggctgag ctccaggcag ccagctgcta tccaatctcc acatctggaa 158040 tgttccaaaa aacctcctat gttttctttc tgcagctaag ctctgatgag caagatttaa 158100 gaagtgcagc cacacacttt tggctgcaca tttttaaagt ttgttattgt cgtcatagat 158160 tacttgtttt gaatcaaaac tttttaaaga aaacttaatc tcccaaattt taaccctctt 158220 gaagtttcag gattcctagg aatactttta ttttaagatg cataaaatac tcagtacatg 158280 tacaaaggta atgcttataa gaaacttggg gaaaaaatag gggagctagt aagattgaga 158340 aggggaagaa tatctgagct aacattacta acctggcgac tattataggt ggctggatag 158400 catggaggca taaagccaaa cactgttaag agaatagact ggatttgaat cctggctcta 158460 cctggattcg ttttgtgacc tcagagaagt tgcttccctt ctctgtgcct cagtttcttc 158520 atatgtaaaa ggagataact atagtgtcta gcatacagaa ttattgtgag gattaaataa 158580 gttaatacat ataaagaaag ttcaaaacta tggcgcacaa atgcttaata tatgtaagat 158640 attactgtta taaaactaaa gaaagagaac ccagaagaca ttcagtttgg tgggattcag 158700 atatgtgttt tcctttcctc ctcctcctcc tcttctgcca tctctaaccc cactatgctt 158760 gccttccaat ctatccctgc ctcctatttc tcttcctccc tgtcgctaaa aatatttaga 158820 agaaaagaag aggtgcatac ttcacggggt gccaagcttt tgggtaaagt acacttttca 158880 gctaacatga ctgtatccaa cagtaatggg ctttatggta agagaaagct ttttttccaa 158940 taagtgggtt ttagcttttt aatggatcat tctctttgta tgggtaattc ttctggaaga 159000 tggaaattgg ctctatgata agatagaaga gttggactca ggcatctaga ttaagggagt 159060 atcatgtatg cttttaggag agaagtttaa tctgcaaaac ctacttgcct tatttaatta 159120 attgttgctc ttagctgctc aattttgtac aggtgacttg catgaaagca aaatatatgt 159180 caaaatccaa aagcagagtg aagccttggg acttcagtgc tttcgggtgt ctttccagac 159240 ctctgctctt cccccaccct caccaaggcc ccactgacct caaagggccc ttcttgccag 159300 gccatgaatt acatctgagc cagagggctg ggactacagc caaagccaaa tgaaggtgca 159360 gaattgagga ctaaaaaaag cctgagcacg tggtactggg tatagcagat aaatttgttg 159420 gagaaatggt ttataaataa catgaaaagg ggaaggggac agagggtcac aatattgagt 159480 tgttgagagt tgttcgatat ttgaggtcag tctcaccatt tttagtaacc caaaagtaat 159540 actgaagaaa aaaagctccc tgaataaaat taaccacagc tgggcttatt ttttcttatc 159600 aagacatttg taagtttggc agcaagcatt tttaaacagg atctctttta tatgaaataa 159660 atttaaaaac atgtgtctgc agtcaggaca aacaagtgaa caaaagcaaa gcaaaagcga 159720 aaaagaagcc ccatgaaggc attatgcttt tctgagtaca gtataaggct aggatactgc 159780 agaaactgaa atacttaggg atcttattga aatagttttc ttttcctcca aacaaagcaa 159840 ccatctcaga gggatagatg ggctaaaaga caaggaataa agtaaacaga agattgataa 159900 cttgggaggt tttcttttcc cctttctcta tttggttttg atttgctttt ccctcattaa 159960 aaccagaaag gataaatttt ggtccagaac tcccaagacc agaggtcagg gaaagccagc 160020 ctgaggctgg aagctatgaa cttatcgcta gtctaaactc cacctccttc ttccctggga 160080 gtcctgcaca aatataactg cctgatcttt ctgtttagtg gcaaaggttt tgctcccttc 160140 tctttcatat gggaatatta atttgggaaa gatttgcctt tttttttttt tttttaaaga 160200 aacagagact tgacttattc ctcccacaaa ctctttccct ggcacaggga gaccacaaac 160260 taagtgaaaa acaacgtaag aagcttagac aaataggacc atatgccctc ccctggagct 160320 gaaacatgca tgctccctgt ccaccatcac ctcgtcttcc tatgcttcta ccccacccct 160380 gtctcttcca cactctgggt cacatgtcta ccccttactg tgacttataa tcacccagga 160440 agggtaacac attgactgag ggccaagctt ctgataagtg aatgaacatg tcttttctcc 160500 ttgccagata tctatctttg ccagagaggg ctgagtcagg gagactaagg ttttcaatgt 160560 caaattgtgt attgtttaaa attgtgataa tttgctttct gcactgaatc tcattttcaa 160620 aataaaatta tgccttaagt cagatcatac tgatgcagat tctgcaagtg ttaagaggct 160680 tctgtgattg catttgccag ctgcaggtca ggcagtggtg gatagtggta agaagtaacc 160740 tatacttttg gctgggagct gtgactcaca cctgtaatcc cagcgcttta ggaggctgag 160800 gcgggcagat cacgagatca ggagattgag accatcctgg ctaacacaat gaaaccctgt 160860 ctctactaaa aatacaaaca aattagccag gcttggtggc acatgcctat agtcccagct 160920 actcgggagg ctgaagcagg agaatcgctt gaacctggga ggcggaggtt gcagagccga 160980 gatcgcgcca ctgcacccca cactccaggc tgggtaacaa agcaaaactc catctcaaaa 161040 aaaaaaaaaa aaaaaaaaaa aatgtaacct atacttttgc agtagaattt tgaaagttca 161100 aattcaaact caggctttgt attttttcca aagtaaattg tattttgttc attttaatcc 161160 attggttgaa tctaatgaga tctctctgac tggaaattct gccctttttt tcctccataa 161220 ctgacttacc agttatctct catccatgta ttttgataaa tccataagaa tgtctgtttt 161280 tgttgtctac caaagccttt ataacaaaac caaattcata gctttgtcaa ctgcacttga 161340 aaattatgcc ccaggctttt caagattctg taattaactt cttgagtcat ttgtttaacc 161400 attggtgaat tcatttatct ttactcgggc cacagtaatg tattttactt acaacatatt 161460 atgagaaact acatcacctg cttcactgaa attgaaaaac gttagatgaa caacactgcc 161520 ctaaaccaca tttcaataat cctttgatga aaagaaagtg agtacatttc ctataatgat 161580 ttgttcttag tgaagccatg ttggcttcaa gtgacctgtt gtttcctttc agggcttacg 161640 gaaataatct aaccattcta aaatattgat ggggatttgg gtcaaaggta tagttttaaa 161700 aattcaccat ctttaacctg ttaaatatcc aaagaaataa tcatttatta tttcatttat 161760 gctttcagta tctaggacat aattaatcta atattgaaca tttgaactta ttgttagctt 161820 tgaaaatatg ccctattcct attggcttta tactcaagtt ttcttaatac attccctcaa 161880 tcgtctccag tcttgttatt gcccttgccc aagaagaaga aaattctgta agagctttct 161940 tttgccttcc tttcttctct gagtggaata atcttttttg ttgtttttat agtattttag 162000 agtttcgcga gatcagacaa aaattacctc agcttatagc tttatctttt aagtggaaga 162060 actctgaact attattgtgt cgtcttgaaa aaatagtcta tggaatatat ataggtagtt 162120 gtgttatttt ttgcagtgtt aagttcacct ttttcttctt tttcttttag tgcattgtga 162180 acatttaaaa ggtcatttgt gcagcatata agaggattga caggtttcca tgcatgatgc 162240 ttaatgtgga ggtgatttct ttccatcaag ttattaggtt tggaataagt aacacatctt 162300 aaaattacaa tcttgatgta gcaaatcatc aggtgggtta ccattacatg gaaagaccca 162360 gtaaaataaa gaccattaag ttccggaccc taggagtcta cagtaagtca ttgggaagtt 162420 ggagaggaga aaggcaacgt tagctaggca tttcattcat tcctccataa atgcttactg 162480 ggagcacgtt gtgtccctgg catcatccta gcttcactga aaagaatgac agatatataa 162540 aatgagtaag tgagaagtaa ttgctcttta ctctcaatta tagctgggca agtgcatcta 162600 taaatatgct tttgtgttct gaacacacac taagcagttg gtcaaagtag taagctagag 162660 aaaactactt tcaaatgtag tctttcaaaa taaaaaaata ataataataa taaagatttc 162720 aggacagttt acctatgacc atttagagat ttaaggatta aaatcaggag agaaggggaa 162780 tgtttctgct ggggaaagat ttttaaactg gtgttttcta ctcagctact caaagtgatt 162840 ttttaaaatt ttcttccttc tattacttat tggcctttat tgtggggaag actgctctgt 162900 tggcaacatg agagagatgt gaatcaagaa aatggaaaca ccattcaata ttcaaaagcc 162960 actatccccc taaaagcaac cacatactca gattgcacac taactggagg atgttaaaaa 163020 gtgttctgtt aaaaccagtt atccagtttt tgctacttaa actctgctgt gagaaatgtg 163080 actatagagc agccttaaaa agagatcatc ttgatattaa gcagtgttac tcatacatgc 163140 ttattgacat tctaacaggt gactttgaat ggatcttcag gctcagaaac atggttgtgt 163200 gcctagaact ggtgactgga acaaggtgta cagaagtgaa atgaccactt gctttctcta 163260 ttggatttct ttatccagct gtgcatgtgt ttcagggact acagttgatt ttcttgatgc 163320 aagcctagca acttgttttt ccgttcaaca cagtaaaatc tgagcaggag agaactccct 163380 gttggccacc cacctcacaa tctttaaaag ggaactctgt acagaagcat tccacattag 163440 gcaaatgtac acttctgcaa tcaaaatgaa aaacacttga gctgaatcgt tttccgttag 163500 ctttcgtttc cagccctgat taaaaagaat gcagggaacc ctgcaagttt aagcagtttt 163560 ggcaggcgag gaaacagctg tgacattgtc aagggttgtc tgtaggagct gtgcaggctg 163620 ctgacagtac tgataatgcc cagaaatggg gcagacgctt ttcacatttg gtcatcaaag 163680 gggtggcagc agctaggttc aaaaagtgaa cttttgaccc tgtctgagac aactggctct 163740 catgaatctt gttctgtcat tctccagtct gattttctct ttcagagcaa gcgggtagga 163800 tctttggttt taagactgat tgactgttat taaaagtagc tagttcttat agctgcaatt 163860 ggaaaggatg gaaggtgagg aagaagagct ggtatttccc actatcctgc aggagtgggg 163920 aaatctatca atgactgttc cactaatctg tggatgagct atctagggag ttatcatgca 163980 gttgccaaag ttttcagcat ctaaaagcct ccaaagttct ctctgtgagg ttccacctcc 164040 cctctctcca gacccttccc atgcccctca gattcagcac ttgtccactg tccttgctac 164100 cagggaatcc ctctgcagcc ccctcaccct cctgcccctc ccaaaagagt tccagacttt 164160 gacctgtccc ttccacctca acatctgttt gtgtcctaaa ctgatggcca ttgaaagaaa 164220 cagataaact aattaatgct gaggtatgac taattaagta ttatcaatgt gctaactctc 164280 tcagggttat gtgcatttta atagaggacc agcagtccaa aggccggtct cactccactg 164340 tgcccctcta tcagcacgga gtctattgcc aggcagccag tgaccaagcc tgagaacttg 164400 ccccagatca gcagcctccc cactgagaaa gcaagcaaac tcaacagttt ttcagtgttt 164460 cagggaggct gcagcagcaa tccagttcct tcaaagggtc tgtggattct ctcagctttc 164520 ctagtatgtt gctgtggtag ttagttcttg gagcagaagt tcacaatgtg aatcttcaca 164580 tgctgctctg tgtgccgagc gggtgttgta agttaattct gcccctatct gccatcttaa 164640 tcctaacacc ccccatgttt gtttaattta acttttattt tagtttcaga ggtacatgtg 164700 caggtctgtt atacagataa attggatgtc atgggagttt ggggcataca tgatttcatc 164760 acccaggtaa taaacatggt ttccaatagg ttagttttta tgtcatcacc tgcctcccat 164820 cctccatccc caagtgggtg ccagtgtcta ttattccctt atttgtgttt atgtatactc 164880 agtgtttagc tcccacttat aaatgtttag tgttctgttc ctgtgttagt ttgcttagga 164940 taatgacttc cagcaccatc catgtggctg cacaggatat gatctcattt tttatggctg 165000 catagtattc cataatgtat atgtatcaca ttttctttat ccagtctact gtcgttgggc 165060 atttaggttt gtcccatgtc tttgtctttg tggatagagc tgcagtgaac atacatgcgt 165120 gtgtgtcttt ctggtagagc aatttatatt ccttggattg tcgggtaaaa tagcagttcc 165180 gttttaaatt atttgagaaa tcgtcatcct gctttccata gtggctgaac taatttacat 165240 acctactagc aatataaaca ttcccttttc tccacaacct tgccagcatc tgttattttt 165300 tttttagttt ttagtaatag ccattctgac tggtgtgaga tggtattcat tgtggttttg 165360 atttgcattt ctctagtgaa tagtgatatt gagtattttt tcatatgctt attgtccatg 165420 tatatgaatt cttttgaaaa gtgtctgttc aggaacatca ttcctatgaa aatgctagtt 165480 aattatgcaa gtattacttg tttccattaa ttgagttttt taaaaacctt ataatcaata 165540 ttgcactaaa attttcagct gtgtgattcc ttatcacttt cttggatgca aatgccttgt 165600 atcaggtact atatctcata aatccacatt gcatctaaca atgtagacaa ttaataaatg 165660 cttgtttaac aagcggattt gtttttgctt tattttgctt tctgtgtttt ccttaggatg 165720 tggggcatta ggccaatgga aactgtctct taaaagttct tacatataaa tattgatgtc 165780 aaagtaacta tttttgtaca aataaacaca tttacctaat ttggtgagca tttatagagc 165840 cctgcctata ttcaagggcg ctgtgctgat cactgggcaa ctgaggaagt atgaggcact 165900 gttaccgctg tcttccttcc caaattgggt cctagaccgt atcttggtag agctacctcc 165960 taaggaagcc cacctgtgct attgagggta catctgaagg cagtgcactg gaatgtatag 166020 cctaggactg gaatttggag tgaggccctg agagatcata cacatttttc acttgtgggg 166080 gaatgtcctt aactagaaat agatggtgat ttcagatatt tgatccaaac ctaacttcct 166140 catttgaatg gagtaaacta ataactgttc ttgaggctct ggaatagtga tgaattttcc 166200 tggttgggaa ttcagatgct gatttctgaa gcagagtttt aaagttgaaa gatgaaaagg 166260 gaacagaaca ataaactcaa gcttagaatg aagggtcatt tttctagtcc aacttccctc 166320 cacctagctg ccacccaaga ttgtccctta gccatcctta gaatattaaa ataaatccat 166380 tgcagtgccc aaatgacttt tttctatttg aaaatccttg ccattggaga atttttctat 166440 atatcttaaa tggttcttca tgaattttgt caagtttgtc agcaatgtgc tcatgacagt 166500 atctcatatc tatgtgtatt ctaccacttt agcctcctag acttctagac cagcagttcc 166560 caaactttca aatatgaccc cttttaatgt caacttctgt ttataaaagt acaaaagccc 166620 tcacatctta tacttttttt atgcttttat ttattgagat attagacaac acacacttgt 166680 aggtgacatg gattcttaga tctaaataac tccactctcc atggtcattc tcacttcaac 166740 acaggttgat gcagtcctta gtttggaaaa cagttttgac gtaaataatc ccagactttc 166800 ctgtcacttt ttggagcttt tttcttcatg ctttctttgc atctttctta aaatgtgaag 166860 actacattgg atatattatt aaaataacat cattactagt gctatgttta aagctgactt 166920 tttcttccta gccactgata tagcagtgcc aactgtggac tttctataga atgaacactt 166980 tagaacacaa acactgtcac ttgtaaaacc cttcttttta tcagaacagc agttagactt 167040 tgtgtgtgtg tgtgtgtctt gtgcgtcctt tatatattct acaaattatt aaagacacca 167100 aagacctttt gtttatgtga ggttttgtta ttgatactta ctgtcttagt aattaaatgt 167160 aagaaaattt ttaaacgaca catctcatta gctgtcagag catcatcatg tcttgtaggc 167220 tctggaaaac tccatggtac gctcatgaag aatgagtgtg aaagagacaa atagtagctt 167280 aatgttatta taataatagt tggactttgt gaactcacca atataataca tattcatgac 167340 acagtcccta acatctaaaa acttacaatc taaggcccaa cataaatact aatagatgat 167400 gttaaattct agcttcacag tgcttcctac aataatacta aaaatatgtg aatttagaca 167460 gaggccaaaa tgtgtttaat aaccacttgg ctttgcttag tattttatta cccaccttgg 167520 agaattggcc ctcctgtttt gcactttatg agaagcagcc ctatgaaatg ttttatcaga 167580 agtttaacaa tgatgtagaa cacactgttt cattttataa tgatccttgg gcaaaatggt 167640 ataatatctg taggagaaat gctaaatgct gcagtaaaaa ctcctcagaa tcacgtatgt 167700 ttttatcgtg tggtcactat aaatcatgta actgtgcttt ctgatctcct ttggccacca 167760 ggaagacaag aactgacaat ccatttattg taaattcttc agggtctgat gtcattattt 167820 ctatgtaaga ttttccctgg cattatctta tttctcaggt ctcatttttc ctttgttctg 167880 atttattttt cttaatatgt tttattgtgc atttgttaat atattttgtt gtgtatttaa 167940 tttccaatgg ggatgaatga ataagtggga aacagagata cttgatccaa ttgacaggga 168000 ctgcttgagt atctggagtg gtgcagatca agcagggtaa ttgtatcagg tttcattaat 168060 gaaatgggtc ttaaggggag attaggaagg aaaggaagtg ggttgctgga gaggcggggt 168120 gttttatgtg gcagatcggc tgtaatcaac atgcagctgt ggagtgagtg agtgatgtcc 168180 tgagcacagt aaggagatct ggctgacgtg gcatggcacc tcattgcctt aatatctttt 168240 catttgattg aagaggcagc tgagggatag gtgctcttga aaagtggagt aaccatttgt 168300 aattaaggag gactctcact tcagtttcta aaataaatta gaagggagaa aatataaagt 168360 ctgagagatc aattaggaga aagttctggt gctatatata gaaataggcc tatctgcata 168420 tgcaggtgag agtatgaaga agaatctgtg aatggcagtc attttttgta gctggttcca 168480 attaaaattg attctttact atcgcaagaa cagaaaacca aacaccgcat gttctcactc 168540 ataggtggga actgaacaat gagatcactt ggactcggga aggggaacat cacacaccgg 168600 ggcctatcac ggggaggggg gaggggggag ggattgcatt gggagttata cctgatgtaa 168660 atgacgagat gacgggtgct gacgagttga tgggtgcagc acagcaacat ggcacaagta 168720 tacatatgta acaaacctgc acattatgca catgtaccct agaacttaaa gtataataat 168780 aaaagaaaaa aaagttggaa aaaataaaaa aataaaaaat aaataaaact gattctttat 168840 aacgactact tattggctgc tgctcaccag gtctgctttt ctcatcattg tgtgcagaac 168900 ataccacagt atacactaca gagtaggtgc ttcataatgt gttgaatgga tgaaatgggt 168960 tcctgcctcc aaaggagatg gaaaaaaaaa aaaacagaca ggcaagtaaa tgaagtgaaa 169020 tatgtataaa ctgctttgag aatgttttat aaaaaaggac agcagccaaa cagcattcac 169080 agtaggctgg ctggagtagc agtccttgaa gaaacccatg gaaacagcgg tagaagcaaa 169140 tgtgcaatag ctctgccttt tcacactata gggcagcaca taaatagtcc tggagcacca 169200 gggtccttgt ggatttttta agttacctag ttggcacagc attggctcct cctctcgtgt 169260 gattaggggc caggatacaa taaaaatatg ttatgttgga actttgatgc cagccttaac 169320 ttgccagttc agcgtttgtg gttgcaggta gtatcagctc ctctcctggt atgattgaga 169380 gactgaagtc caaggcttca ggttgaacag aattgattgc cttaaggacc ggtttagaac 169440 tcttccatag cacttgacag gaagccagtt tatttttctt ggatgccagc ttccaagaaa 169500 agatcagtct tgagcaaaat agttcttcac tctcagctca gaagcctaat tgagagggtg 169560 tcctctaagc atcacagccg actctgctag taacctgttc tacttcaacc tgtaaggccc 169620 atgaggctgg ccagtgacat cactacagga cacagtggag gatgtttagg aatgactagg 169680 tgatgaccag ggtgcagact gtgtttactc aaggctaatt gagaggtact attttcagtg 169740 gtgtgcttat aaatgtgtaa cagtactggg ttgaagggag gctctgactt gtagcatttt 169800 gctagtgtcc atggtgtaaa tacccccaac atgactaact ttaagttacc aatgtgattg 169860 aaagtagagt ttggaagaga ggcacagtag cccactgtta tgtagtactt ttgccataca 169920 gatgcataag agacataagt aacctgaaga acatagataa ttattaaatg tagtgaaatg 169980 attatgaagt gacagatttt aagtgtttta tcacatttgt ttttaatatc atttaatttt 170040 aagttgccat aatttaattt gtaattaagg ctatgttaat aattggctta tggaatttct 170100 gagaattcaa aaaccagtgc ctataggtgg atccagtaca ccactaggta agaacagcct 170160 agaagtactt ctaggctctt gttctgaaag atgccaagac tggcatccat ggttccagtg 170220 ccagcgcaag gaaagactta ctaggtccta cagtattgct cccaaatctc tttcagtggc 170280 cagggaaatt atcggactga aggcagagtg aattttgctg aatggcttgc ttatattcag 170340 gtcctagtat ctatgattga taatcagctt catttgtaag tattggatgg tgcaactcca 170400 tgcatccagg aggctgggag gtactgagag cagagtgata gtgtcaaaag acactaaaat 170460 gaatgccagc tctctcctgc catatccact actaagtgag aaattcagtg acatagtcac 170520 tgaggactcc accactgctg ggtgttgggg agggcacact gaacatttca agacaatctg 170580 ggtaagattt ttcttggagg gattcaagta cgaaatagtt aatatgcaga aatgaagggg 170640 aaattattat accccagaaa tgagtcagat aatactaaag aaaggaagaa aggaaagcat 170700 gacttgaatt ctgtctttaa tgatgaccac agaagaagtt gggtctttaa agatgacaag 170760 agaagactga tcaggtagca gtgaggtggg aggggaaaga tgagagaggg gacattccta 170820 gtagaggaag taaggtagac aaagtgtagg aatgtgaaag agcataatgt gtgtaaatat 170880 tgttcaggtg acttcttggg tacctaggta ctagataaag aggaattaga aataagaatg 170940 gaagaagggg agattcaggg ccaggttgtt gagggcattt tatgccatgc taaggagttt 171000 tgaatttttc ctttcagtaa tagcaagaaa cttaaaatga gcaggagttc gtgtttttga 171060 aagaactagg aaaacacctc tgggcactcc attacctggg aataatgggt gaaatttccc 171120 aagttagtgc acaggctgct gggtagggct tgaggctttc ctcttgcctc ctatttcaac 171180 actgtggtct tttagggctt gtcctcaaca tgttcttaaa aggaatgttt gctcactgcc 171240 aaaacagtag tcttcatatt tgttctgttc ctttccaaaa ggtaaattga aaaagcaaca 171300 taccctcagc caaaagaatt aatcttttat cacctaagtt actgcccact gccttttagt 171360 tttaaactta atttagtgtg cataaatggc tataagccct tggaactctc tttatgtttg 171420 catcttaaat ttaccagacc ctccttctat ctatagttcc agaattttct ttgtcttatt 171480 ttcttcaaga aatgtatttc tttaaattgg attgcaaatt tggaatacac acagccaaag 171540 gctttcaaaa tcattcttgt taaaagggac aagttacttg agaacgtttt taaaggaaaa 171600 agttaaaata gatgtcaatg gaagatgcaa atacgaatat aaaatatgaa aagcatctat 171660 aggctggagc ttctcaggag agctctactt catttaaagt catattatct ggcaccattt 171720 caaagctgtg ggttacttga ttttgtagtt agaaaaaaag tataaagttg aaatattgag 171780 ctctttacat gacctttttg ctaggagcag tggatgaaac tatcctctaa gagatcaata 171840 gctttagtgt aaacttggtc aataccttat tggaagaagt aactatgtca gattaggtag 171900 aaattttaga agccagcaag tttccaaatg tccttctgga attggcctct tagggccatg 171960 tggaccagag ggatcttatc acagcagtaa taaactaata tctattagcc aaatctagct 172020 catggacacg ttgtttggcc tataccacat tttttttttt tttttttaaa gacagagtct 172080 cactctgtca cccaggctgg agtgcagtgg cgcgatctcg gctcactgcc aggttcaagc 172140 aattccctgc ctcagcctcc tgagtagctg gaattacagg cacccaccac catgcctggc 172200 taacttttgt acttttagta gagatggggt ttcaccatct tggccaggct ggtcttgaac 172260 tcctgacctc gtgattcacc caccccctcc ttggcctccc aaagtcctag gattacaggc 172320 atgagccacc acgcctggct cacaccacat ttgtatgaag ttgaattggt tatttttaaa 172380 aatttgaaga atttaacaac aacaacaaca aacttttgtg tccagcattt tttttttttt 172440 ttaactattg ggacaatcct gggcctgcat tctttgaaca gttggctaca cttaagtagc 172500 tgctgcccct tttagatggg gcaagcgttc tctacttttt cacagtccct ttcaagggtg 172560 cttcagccat ttttgatact cacttggctt caataaacca aggtcatgtt taaaagatta 172620 aataacagtt attacacacg caccaaaccg tcagagggaa ccagacttgt gtaccagaac 172680 agagtcctgg agcatatctc tgttaggcta gacatcactc ttttagttat gggatcacgg 172740 aaaggtgcag aaagttcctg ggaaggggtt gggagggatt ctggaggatc ccaagtgtga 172800 ctcacacact tggaggcttg agtcaatagc tttttaccag ctagcatgaa agtacttcta 172860 gtgtttaaaa acctatggca cagtgggatc ttctaggaaa gtagaccctg gagatggaga 172920 ttcgaatata gcacatttat taaggggtgc cactagtatc gatatctgta gaagagagag 172980 aaaggatgtg agagtgggca gagggagaag ttgagctgca aagcaggccc agtgccagcc 173040 tcaactggct ccatgaggag ctctggagct ggaatgcccg tttatatttg tttcccatgg 173100 gatcaagatg gccaggccat tctactctga catgcatcac tcattgaaag tggaaagact 173160 cttgctcttg aatgaggcaa tcctctgcca ctgaggcaat ccctcaaagg agtaagaagt 173220 gaaagctgtt ggcctggagc acctgcagca tctgaaacaa gaaatccttc attgaacagg 173280 atctgggcag cacaccagag taatcacagt cagcagctgt accagtgaca acagatgaat 173340 atcaactctg cctttagccc ctagggtgtg acacctggcc tatagcttat ccaaagctgt 173400 gcctaaactc tttggactga ttcagaatca agctagtcct agcctaaaga gaggagttta 173460 atgtcatgct acactctaac ccaatatttg ctggcttgta attcagtcat taaagaaatt 173520 ctttttattt tcacatagtt ttagattgtc aaactgttac cattctgtgt tcagaaattg 173580 aaacctattc tttctattct tttttttttt tttttttttt tttttttttt gagacggagt 173640 tttgctctct tgttgcccag gctggagtgc aatggcgcaa tcttggctca ctgcaacctc 173700 cgcctcccgg gttcaagcga ttctcttgtc tcagcctcct gagtagctgg gattacaggt 173760 gcatgccacc atgcccagct aatttttgtg tttttagtag agatggggtt tcatcatatt 173820 ggtcaggctg gtcttgaatt cccaacttca ggtgacctgc ccccctcggc ctcccaaagt 173880 gctgggatta caagtgaaat ctattcttat attttactgt aacctcagaa aagaatgctt 173940 ttttgaggac tagaattctg tctcttttgt tgtcgtctcc tttctctttc ccaaacctgt 174000 aattctattg tgcttaccac acaatgaaca atcagatgtc ttaaactgcg gcttacataa 174060 ttaccagtat aacctttttg cttttatttt tttctttcat tttaatctgt tcatgaggac 174120 tgttacccag gtattttaaa aatctcactc cattgtttta aggttagtgg ttccaaaggg 174180 attttagaga ccctgaccca ataatagtta tatttttcta agtgattctg aagcaatggt 174240 cccaggtaag aaattgcagt tcaaagcaca tcataggttt gttattttcc aaattcttat 174300 taaagcatta atgcaaatgg aattttccta ctactcctct gctttctcta atctttgaca 174360 ggattaattg ctacactata atatgatttg ttataatttt atgtttatat taaagatata 174420 gaatatgatt gccctttgat gtcaaatact aaagattctg ctactgtttt agttgtgctg 174480 gttcttatct tccttatctt tcattcacct tttcaattca tctcataaac atttaatgaa 174540 aacttattgt atatcaaggg ttgtttatta taggaattgt aattcaaaaa ctttctttct 174600 ctggtctgaa aattttagaa acataaaagg aaaaagggag ggaggccaac tgagagtata 174660 aaaataaata tggcatttat taacaattaa ccagtttctt ttttctataa taatttatcc 174720 agtaaattgt atttttaaat tattgtttta gtttttgttg catatgttta aggaatacaa 174780 catcatgttt tttataatta ctagagtcaa gcaaattaac aaattcatct cctacatagt 174840 tatcttttgt gtgtatgtgt gtggtaagag ttccagaaat ctactctatt aacaaatttc 174900 cagtatggaa cacaatatta ttaatgatag tcctcatgct gtacgttaga tccctagact 174960 tattcatcct tcataactgc tactttgtac catttgaact acattttcac atcccctgtg 175020 aaaatgggag ggggacggta caattcgcat ggaatatctt tttccatcac ttacctttta 175080 gtgtatgtat gtactcagat ctaaactgag tttcttgtgg aaaccataca gttggatctt 175140 cgttctttac ccattcggcc gttctgtatc tttttattga gggctttaga ccatttacaa 175200 tttaagtaat tattggtggg gacagatttt tttattatta ttattatact ttaagttcta 175260 gggtacatgt gcataatgtg caggtttgtt acatatgtat acgtgtgcca tgttggtgtg 175320 ctgcacccaa cttgtcagca cccatcaact cgtcatttac atcaggtata actcccagtg 175380 caatcccttc cccctccccg ctccccataa taggtcccag tgtgtgatgt tccccttccc 175440 gagtccaagt gatctcattg ttcagttccc acctatgagt gagaatatgc ggtgtttggt 175500 tttctgttct tgcaatagtt tgctgagaag gatggtttcc agctgcatcc atgtccctac 175560 aaaggacaca aactcatcct tttttatggc tgcatagtat tccatggtgt atatgtgcca 175620 cattttctta atccagtctg tcactgatgg acaattgggt tgattccaag tctttgctat 175680 tgtgaatagt gccgcaatga tttaatcttg ccattttgtc aaccgttttc tatttgttta 175740 tgattctttt ttctcttgct gtcttcttca gtgttttgtt ggttttttta tattgatagg 175800 ttttgatttc ttcttttgtg taacttctat atattttttc tttgttatca ccaaggggct 175860 tacataaaat attttagagt tgtaactgtc cgatttatgc tgatagcaac ttagcttcct 175920 ttgcttataa gaactctctg cttttacctc ttctccccca ttatatgcta ttaatatccc 175980 aatttacatc tgtttatatt atgtatctag taacataatt tagttatagt tgttttaata 176040 cttgtgtctt ttaatttgca tagtagaatg aacatagtta cctaccactg ttatagtaat 176100 acagtattct gtattttttt ttttttacca tgttccctac tctactgctt tctttttgtt 176160 tcaatttgaa gagctatctt tggcatttct tataaggcaa atctagataa actctctcgg 176220 ctttgtttgt ctgagaaatt ctttatcttg cctttatttt tgaaggacag gattactggg 176280 tatagcagtc tttgttgtta ggtttggtgt tttttttctt ttttcagcac ttggaatata 176340 tcatccaact tccttcagac ttgcaaggtt tctgcagaaa aattgtctga taatactaca 176400 gaaattttat tataagtagc aagtcacttt tctcttgctc tgctttcgaa attctctttg 176460 tcttcaactt ttaacaatta taatgtgtcc tggtgcaggt ctctttggat tcatcttgtt 176520 tggtgtcctt tgggcttcct ggatctggat gtttattttc ttctcaggac tgggaaattt 176580 tcagccatta tttctttgaa tgtttttttc tctctcttct tcttttatat attccataat 176640 atgtatatga gttcacttga tggtatccca taattccctt aggctatctt tacttctttt 176700 cattcttttt tctttttgct tctctgactg gataatcatc aacaatctgt ttttgagtta 176760 gccaatcttt tcttctgttt gatgtagtct tctcttgaat accttctgaa taaaaacaaa 176820 caaactcttt ttcctctgct ctcacagttc aacaacaatc agtaaggaag ccttttgtga 176880 caaaatgtgt gtttggggaa ggggtaattt ccttcataca acaagtaagc aatcagttct 176940 gcagtaaata ccaatttggt gtcctctaat tcaattccaa cacttctact gagagatctg 177000 cagactggga gctcagtccc tgagactgtc ttcctcaacc aacttccaat gccaattgca 177060 aaccccaggt tattttgcct gtacttctta ctgactggct ataaactggg gttcccacaa 177120 cccccttctc aggttcaatt aattttttag agtggctcat ggaacttgga attacaaaga 177180 atattttaag ggatacaaat aaacagccag aagaagagat gcctagggta aggtcaggaa 177240 gggtcatgag tacgggagct tctgtccttg tggagttggg gtgcacaacc cttcggacat 177300 gtagatgagt tcttgttcac cttcctgtaa gccttcacat gtatagctat ctagaagctc 177360 tctaaatcct gtactctttg accacttatg gagacttcac tggaaaggca tgattgacaa 177420 tcatgtggaa atgtgattgg acaaaaaagg tattagctag tgctaacaga ctgaatggaa 177480 aacccagaaa ggcctgtctg ttcagattct tcctggtctc tctctctgca gcattctttc 177540 ctccagtgaa tggggcagga ccttttttga aatgaaaatc ttatgacctg caatcagaca 177600 aagtaggtca gagaatttct ttatggccag aggcagggaa agacttaagt gtatttttag 177660 tttctgttgc ctgccttctg gagaaaaagg aacaggtgaa tagagggtaa gagaaagtca 177720 gacagagaga ttctgttttt gaggcctgct tctaagtgtc taaagcaccc cagcattata 177780 ataaaagact gtaataagag ctaaggaagt tatgagccag gaaatgtggg caaaataata 177840 tcacagccct ctattatttt ttatttattt attgtattat ttatttatat aatttctgtt 177900 tggtactttt taatattttc tttttgatga aatctcacac agaccatgca ttgctctcat 177960 aaactcagtg agcatcttta tggctgttat ttttaattct cggtgaaatc ggttacctcc 178020 atttcattag ggtcagttta tagagattta tctagttctt ttgtttgaaa catattttcc 178080 tatttcttta ttttccttga ctacctagtg ttttctttag attatataaa ataagcatcc 178140 ctcccaatct tgtcagattg gctttgtgta gcagaggtac ctcaccaatc aacttgacca 178200 gagatttagg gtgcctcttt ttattttttt gagacagttt cgctcttgtt gtccaggcta 178260 gagtgcacta acgccatttc agcttaccgc aacctctgcc tcccgggttc aagcgatttc 178320 cctgtcccct gtctcagcct cccaagtagc tgggattaca gccatgcacc aacatgccca 178380 gctaattttg tacttttttt ggtagagttg gggtttctcc atgttggtca ggctggtgtc 178440 gaactcccaa cctcaggtga tccatccacc tcaacctccc aaagtgctgg gattacagat 178500 gtgagctaca gtgcccggcc tggggtgcct cttaaacttt tgtgcttatt caaaccacca 178560 gttttgttct tagtggccct agataggaag gtcccaagtc ctaagttagt gcccaaggta 178620 gaaacctgtc gtccctcaag aagcagctgg aaatgttgag gctctagatg agtggtccat 178680 cttcctctct cctcagggat aagctgggat ctggacttta tgccgcactc accctgcagt 178740 aagccagaga gaggatcggt gcaaaatgct tgtgctctgt ttcagacaat gcagtctcta 178800 aacatttact ttgctctctc atccccagga gacttgcaaa tggcaagtct ccttagctgt 178860 cctggataag aaaattagct ggaagcttgg ttatgtttct ggagtgagga gctgcaggaa 178920 gtgccctcat gcctgttcag actcccggag gtctactaat tgcctgctcc atcagctccc 178980 tgatgcaggc taattaatag cttaatccac ggactgcagc taggaaagtc agaatattat 179040 gtacgtagtc taactccatc cagggagaaa ctgagagcta ggtgtttttg cttgatcact 179100 ctgcactgag tttggggaac tagctgctgg tagtgcactt gagctcattt aaaaccactt 179160 ctttgttcct tgcagtcttg ggggactcat aaatgctaga tccccttagc tcccagagct 179220 aggtgattta agagccagtc tctcaggtgg gagctgtaaa agatggggtg ctcaatgtat 179280 ggacaaactc cttccaggga caggagagat tagatgcttt atttcatcat tggattgagc 179340 tgggggagaa ggcacaggaa atgcccacac actagtgccc acataccctt tcaggctccc 179400 agaggtctta ctaattacct gccccactgg ctcttagccc acttagtaat gctataagga 179460 atacctattg ctgggtaatt taagaggaag agaggtttat ttggttcgtg gttctgcagg 179520 ctgtacagga ggcatgatgc tagcatctcc ttccagtgag ggcttcaggc tgcttccact 179580 catggtggaa ggttaagggg agctggcatg tagaaatcac atggcaagag acgaggcaag 179640 aaagaaagaa agagaagaag gtgccaggct cttttcaaca atcagttctc tcatagaaac 179700 taagactgag aacttaccca ctgccctgac aagggcacca agccataaat gagggatcat 179760 tcttatgacc cagacacctc ccacaaagtc cacctcccac actggggatc aaatttcaac 179820 atgaggcttt ctggggccaa acaaaccaca tcaaaacccg tctcccagtt ttagactatg 179880 tagagtttta atccttgggc agcagctggg aaagtttgca ataaaacccc taccagagag 179940 aaactgagcc tgagggaatt ggagtaggaa gttcctgcac acctgtttaa aattgtctcc 180000 ttgttctctg tggcccagag atatttgcaa atgctgagcc tatctgctcc cagagctagg 180060 tgaattggtg atatggtttg gctctgtgtc cccacacaaa tctcatctca aattgtaatc 180120 cccatgtgtt gaaggaggga cttggtggga ggagattgat cacggggaca gtttcttcca 180180 tgctgttctc atgatagtga gtgagctctc acaagagctg gttttaaagg tgtttggcag 180240 ttccctcttt gcttactttc cctctctcct gccaccatgt aagatgtgcc ttgcttcccc 180300 ttcaccttcc accatgatta taagtttcct gaggcctccc tagccatgtg gaactgtgag 180360 tcaattaagc ctctttcctt tataagttac ccagtctcag gtagtttctt tctagcaatg 180420 tgaaaacaga ataagataag gagcaagtcc ctcagggagg agctgtaaaa gctgaggtgc 180480 tgtatgtgta gttccaaccc tttaatttct aagaaggtaa agctaggagt tgggtttcct 180540 tcctgattac aaagtgatgt gcctggggtg gggcttttgg tatgaattaa ccaatttctt 180600 aagcatcaac ttggtgttcc aaactgtgct aagggctagg gaagaggctt tgttatcctt 180660 atttggagag agcttatagt ctaattagga ataagaaaat tgacacaaaa taacagcaaa 180720 taacaaggca acagaatcag ttgctacatg ttatggtggt atataaataa atgatggtag 180780 aatttagaaa actgaaaggg gacagggtag acaagagtag tcaggaaggc tgcatggaag 180840 agaaggaact tgatttgggt atagaagaag gggctgggat ttgggaagac aaaaagcaag 180900 aagagggcca ttccagtatc caagtaatga cagatagagg gacagggcgt gtatgtatta 180960 acatgagaat agcagaagtt tgatgttggt tagaacttac taccaacttc ttacagaact 181020 ttcccttaaa aattctgagt ttgaaaacat tcaacacctc aatctacttt caagatttcc 181080 tggcaaagtg aaggaagcaa atacctttat tattttacaa ctgaagttac ctgctttgtc 181140 agttatgatc taggctgatt ctaactacct actggcaacc tagaacagtc aaaagaccta 181200 ggaattcatt caaaagacca aaatctgcat tgtctggcag tgtgagcatg agcaaatcac 181260 ttcatctcct tgagccccag ttttctcatc taggaatgaa aagtagagcc ttatctatct 181320 gaccaggtta ttatgctatt aagttatatg agtaaatggg aaaattcttc ttaaacaata 181380 atacaaattt tagttggtac ttttgttaac atctacacta gaccacattt atataggtaa 181440 tttaaaagta aaaaagaatg gggaattcat ttttatgtca tggatttaga ttttttcata 181500 gtagaaagtt aatcattcag cagtgttttt tacatttcaa gtagcaacca tcatattgcc 181560 atgaaattta tttagtagcc cctaactatt tttttttaat gaaatagcat aggatgaaag 181620 tatagtgtat attgtacttt ttagggcagt agattatatc attcatcata gagataagtg 181680 tcgtttagtg acacacaaag gcataagtga catacacatt ggtcaaaatg taaaatatat 181740 ttctttttgt agattgttgt caaagaagat tgaaagacat taattaacgg tatagtattt 181800 caaatataaa atcctcagtc ttcatatttt gaaccttaaa ttatactaac caaaaagata 181860 aatttcagag aaaagttatt ttatgtaaag aaagtgaaat tttgatgaaa tgagacatgc 181920 taccacatat tctttatttt attcttatgt ttcttgctga aacccaaatt ctgtcttcac 181980 ttctgctacc caagtataga aagcaaaggg tttgcttttt gcatttccat caaaatctac 182040 atgcctagaa actcaatgtg ctctattttt tctggtagtt cttgagttgt ttattttaac 182100 tatcaataaa tattatgtaa tttaaaaata aaacttaatt tgtgacaaag tcagttttca 182160 gtctgggttc acagaagaaa gggatggcat atgcaaaaag gatgtaacca ggaagagtgc 182220 aataatatgt ctatatacaa gagggttgat ggagttaagg aaaccaacca aggatggtga 182280 agaacccaga gctaggaaga gggtactagc tcccaggcgt gaaagggcac agtgttctag 182340 gttccagatg tgacactgat cagtgggaga ggagcagtat gactagtgcc atcaggggaa 182400 accacagtct tttcaggaaa gagggagagg cctggagggg acaggtgcct gtggctgaac 182460 ccagtgaaga ccaagggttc tgggcaatgt catctgtaat ggccaacttc ctggggcaca 182520 gagcagggaa gaggagagtg gaaaatgaat gtggggcaac aaatggggag taaccagcaa 182580 cctatcatat gaatgatcat ttttcatgtc agatggtggc atatagcttt tctattcaaa 182640 ttcagtttcc ttcctctgtt ttctaactgt tgaagtgttg tcttttactt catgcagtct 182700 acagaatatc ctgtgctgtg ctgaaagaag acaattggga gagaaaacat tagtgaactt 182760 gttgtgtaac ttgtcaaatg atttagcaaa cacttagtta aggaaatagc tatacttata 182820 gattattttt taatctccat ttacatgatc acgatatacc tgcttttgca gtttgacttt 182880 gacaagaagc aaactctgag atggagttta gtggcaggac gtttattaag gatcaacgcc 182940 tgtggagagg agcccccagc tgaccccaca aggagctctg gagctaggat attccttcac 183000 gttgctaccc acccccgact cccaccttgg ttgatacagt caggcctttg tattccacat 183060 cactctgtca ttggatctca gatgtaagct agggaatgtg accttggcta aaagaggcaa 183120 tccttgaagg ggctgagatc ttaaggcatc agacacttcc ttccttgaag ggggttgggg 183180 cagagcctca cagaatccat catacctccc ttcattcaac atacttctaa aaaaatatat 183240 tgtgagataa aaatggtttc caagttttga aagttctgcc tctttgcagg aagaagggac 183300 accaattctt gttgagaatc tagataccct ataaagagta accctcccaa agaaataaaa 183360 tattgcattt ttattgagac atctatgatc cttggaggta aggttttgtg gatttgtttt 183420 ttgtttgctt ggagcgctcc ctgtcaagca ttgatctctt tacgttccta agtatgccta 183480 gaactgaaat gaggaattat cttaaatata gctattcatg aagtatccca gtcagtgtct 183540 ttgaataaaa atggcccact aaaagcttcc tattatttct gatgcctcat attggcagat 183600 tctgaaacag gtgactaaaa aggtaaaaag aaaatcaaat tattggggac tcagtcttga 183660 gtttaagcat aatgaggacc cacttggcat taacttttag tcatattccc catcaagaaa 183720 ttgttctcca gaaatcttta taaattagat agttaagttt ctaaaagatg actgtgaatc 183780 taggactgat ctaccaatga cgagaactga agaagcactt gcttaaaaaa gggaagaggt 183840 atttacatgg tacagaaaaa aactgataag taaatagtcg gaaaaaaaaa aaaaaagcca 183900 ggggtattcc aaggaaagcc taagaagaaa aaaattcaaa atgcagggac aaggataagg 183960 gtctgtatca gttataaatt ctttttagtg caaataataa aatatcccat taatagtgac 184020 tcaagctata tgaaccttta ctatttacct aaaaatcaat ttagaagtaa atgatctcag 184080 gttttgttag aaagcttagg aaaatcatca agatctcaag ctccttctgg atttctgatc 184140 caaccccagt cagttatttg gcttcactgc atcatggtca catggcaact gaaactccag 184200 acagtgcata cacgttcaag gtaggaatat gggagagaaa gtggtgttaa tgagctcttc 184260 ccttgcatct tcccatcttg taaagcatct aaaggttttc cagaaggcct cagccaactc 184320 tcacttatct atctttagct ggttctgtca catgctacct tcagttgcaa agaatgttgg 184380 aagggtgagc atgtggaaag gtgaatgagc tgccctaact ggcctagact aatcctgatc 184440 tagcccatgg tagggtactt tggttcctag ctgttgggta gccaaccagt ggtgtctgcc 184500 tgcaggaact tcttagaagg gccaaagata aaggacgaag tgtcctcatt gatttcatag 184560 acacaaccag ttctagatca ccggttcaaa gagcgtaata aattagtaga gtgggagaac 184620 acaaaattag gaagattcat ttctgcttta ttgtgatctg ggtcaatttt tgctttctca 184680 atattaatct tcaaaaagat atcctttgaa atctcaaaat ccttttctat aatttaaaaa 184740 caaccttacc atctgtgtcc tctgtcatat ggtacaatat tcaagagggt gaaataatgg 184800 tccagtaact aagaaaagac ttaggggatg aattggcctt agtgactgtc actaaaatgt 184860 aaacatggct ttaaaaagta aatcagaagg aatgaaaggg ccttgacagc taaggctctc 184920 aggaagattc tagaaagaca tgaagcacaa ttttgtaagt gtgcgatagg agttactctt 184980 cttcttttat tcatgtgtca tagaagggaa aggaaatttt taaaagagta agaccagcca 185040 gatatcacaa gagtatagag gaatgtaagg atagcatgtt caagggcaac atgaagagta 185100 agagaaaatg tcctggatgc caagactagc tctctttatt gcaaagcttg ccagactctt 185160 tacccagtac atgtactcta ctctaagaag aagaaacaaa gctaagtgac tgctaagctc 185220 atggacaatg tttttgggtc tctccagcag ccacctagtg gctgactagg taaaatcatt 185280 tgtttttctc aagatgttgt aattctgaga atgcagggtt tggctgccat gttagcctgg 185340 attttctgag atgcatccct gcaagagatt cactgagaaa ttagatgtgc aagagattta 185400 tctggggaaa tgcctatgag ggaaaatgga gaaggagctg taggaggctg gaagagatga 185460 acactgcagt acacgtctga tcccagtgat gggaaaaaaa aaaggaaagg aggaatgaga 185520 aaagggaaag aaagaaggag ggaagaaagg aaagagatag ggagggaggg aaaggcaaag 185580 acaccagtgc agtgccaaga aagttttggc aaggctgatg gggagtcttc aaatcaaagt 185640 cacttgaaag aggaatcccc ttatcatccc cccaggaatg ggcctgcctt ggtgtcctca 185700 tgcaaagtca ctggctgggt ggatttcaga gcatagcagc tgaggtcata ggccagttac 185760 actctgccat aggaggcttg agagagcatt ttcatagctg ccacatttgc cactgcaacc 185820 ttctgggagt gatgggttgt gctggaagaa tttgaagata gtatcttatg ctccggataa 185880 agaaatgcat tgatgaaggc ccttcactat tagatttatt tttctgtgtc ccaactatta 185940 tataaattcc cctatcaagg aattttcaat gttttctcct tgcccttaga tacgtgatct 186000 tataccccag gtttgctgag acattccttt tacagatagt tctactggct catgagtgta 186060 atgtgtctaa atgtatggtt ggacaaatac ggttattaga tctaaatttt aagttcaaat 186120 ttccttagcc tgaagtttag agtcttccac agtctagtcc caaccacttt ttccaacctt 186180 aattaccatt gcactttacc ctgtatttca attcatttga aatatttgct cttttctaaa 186240 ttactctcgc ttacccacca ctatctcttt gttcatactg ttctcttcaa ctaagattaa 186300 ttaatcaaca tgtatttatt gtccccttcc catgggccaa gccctgtgct tagaactgta 186360 tgttagggga caaaacgcac atggtttctg tcttcctaga gtttgaattt agtagaagag 186420 caacagacaa tacacaggtc aatggacagt tcatgcttac aaatcatgtg acagtgtcaa 186480 aagtaaacaa agaaggttcc ctgatagaga attacaggaa ggtttatttt agatagagct 186540 atcaggaaag aaatggcatt tcagcctgaa cttgaatgat aaagggaatg tagttactaa 186600 ggacttaagt ccttcagata ccaattccat catcttcaag atattgccat gatcttcaca 186660 aagtttttcc tgactcatca ttggactctc aaccgttttt agccctgtgc tatctgcgtc 186720 ttgtatatta cagaaagtgt ttaaggtcac actataaact aaatgtgttt gtctccaatc 186780 agactgtaag attgtggaat gttagatcca tgtgtgatgt atgtctttgt ctcttatcag 186840 actatatgat tttggaagtt tagagctatg tctgtatccg ctataacatt tatctctgta 186900 tctgcatgat acttaggata atagtatgtg ggcacatcca acaaatattt gttgaatgaa 186960 taaacagtat tccactctct gcaagtttgg cctttctgac atttgtctga attatagaag 187020 gagaaggagg ctttatataa tagttgaaaa ttactgttca cgtaatacag agttctgaac 187080 ttcaaccaga agcaagtcta cagcagatga aaacatttca aatgagggaa ttagctgtat 187140 ataactttag gatagggttg tataagttta gcatttattt gaaaatccat tattatatgc 187200 ataattaagt tttaggaaga aaatctggct gaatagtaaa tcagttacta ttttcaaaca 187260 gttcttcagt agttagttac cactggcttc tagaatttaa ctggtgtttt tttttcagta 187320 tatcacacta gcatgtgggt tgagacacaa cctcacatta caaatgggta gtcccttgac 187380 ttgtagatca atcagtaata atacaactac tgatttttta cagtttgtat aattatttgt 187440 catttctttc ccttattatc tgtattctca gaaacaaaga gtagaaacaa agagaaagga 187500 catgatgtat ttttgatagg ctaccatctc aaattttcat tccaatgttt atttggagaa 187560 acacttttat ctaaaatgga ccttttcatt tgacaatggc acttgctctc aaaatgagaa 187620 ttgcgccttc caggagagtt ttccatctga ctccaaagcc ttgaccctca caaacagtgt 187680 tgtttgtaat ggcccctggt tagaaactct cagcctaaca agcatgcagc atagcccctg 187740 aagtctcccg tcctatctgc ataaatttgg gatatagcac tcctgcacat caagcctcac 187800 ttactcataa aatgccggga atcattccaa attgctcttc cagaggagag tttgttttta 187860 aaattatttc agatagagat gtttcaaagt ctacataaat gcataatatt tttttctgat 187920 tgtgctttct tggtgtttct cttgctgtaa tacctacttc gccattcttc agggagcact 187980 tcaaggactt ttgtaatcca tatagccttc ctaagctgtt ctaactttca gcaatcccaa 188040 ccacatcact gacctagttt gtaatgactc accagacaat gtgttgggtt ctctagtaat 188100 actttgttaa gtccaagtta tcctttctgc tgttgtttct cagtgtgtgt ttctatctga 188160 gctctccagt taaactgtaa tctacttaag cactgggctt tgtcttatac tctacttctc 188220 acaactcttg cctcttaaat tggttaatgt atgtttgatg actaattgta cacataatag 188280 ctacttaata aatgttctta agaaaaggac aaattaagta ttttccctgg taaccctcta 188340 taccaggcat cactgtggaa agatgcagag ttgagaagac agcatttcaa aaactggaaa 188400 aatcacttgt aaattatttc agggattcga ctttgacatt atgttgacat aaaaagagcc 188460 ttaaaaacag ctattagaaa atagacaaaa gtagaaacaa ataaatgaat gagtgaatga 188520 catatctaaa tgccatgaaa tgtgaaaatg atacaaaatg ttaagctaat ccttttttct 188580 tctctaatta atctccactg ggtatgggga atagggaaga actggggtat tcgcaacagg 188640 caaacattcc tgattcttgc cctactaaag atagggacat taggagaaag gatcatctag 188700 ttggaaaata aactggcatt gctaagtcta aatgattgag tcaagtgcaa attttatagg 188760 ccaaatagaa ttttcacaag tccattgact gttgaaaact acttgtaccc tggctcaaag 188820 gacattttct tgctgtctat agtaagcggt ctgtaaactg tgtttgggac cagaaccaaa 188880 tgctagcctt tcatttctca aattatagct tagtaatccc agctcaaaag tccctgcata 188940 cacaatttag taaaattagc agcataaatt tagaaccaga acgtaactat gctttgttcc 189000 ctccagaagt aaaatgtgaa atttcttccc attggaagtc tatttatcac ttaatttcag 189060 atgttgtgat actgttttca tccaatgtta gagaacagaa agaaaccttt tttaaaagca 189120 taactttcat tattcatcta agtttttttc agggtccatg agaaatgcta agattatgcc 189180 ttgtgtttga gaaatagaaa aggaaaaagg gaggaaaacc acctagagaa gtgcttctca 189240 aacttcaagg cacacgtgaa tcacctgggg accttgcaga ttctgattct gaaggtcaga 189300 ggtggggcct aacatcctgc atttctaagg agcttccagg gcatgctgat gctgctggcc 189360 cacagaccat actactttga atagcaagct ttatcggcca tagaggactt tttttttctt 189420 tttttttttt tttttttttt tttttttttt tttttttttg catggaacac agattactgc 189480 tctactctag gttacaattc caaggaaata atgactgaag gaaaatactg ctatttcaac 189540 acttctgagt catttagtta gaatggaagg ttaacattag caatttaatg tggtgggagt 189600 atttattgat gtactaattt gcactttgtt cctgccaaag ctttttactc tgttggctcc 189660 agggagtttg aaagcctagg acagaattgt acttcctagg tttgtttacc tattgtggca 189720 aagaagtgag catctttgga gttaaggaga gttaagaccc aaggagaaga aaaagaaaaa 189780 ctatgaaggc tttttaaaat gtgtatccct gtgtaagatc tccaaggacc ttcccttgac 189840 ccagtagtag caaacggacc acagtgatgg ctgaaattga gtatctcact aacttggtaa 189900 aagttgggca ggctcacagt cagacttaaa tcattttaga gaagtacaat aatgtggcat 189960 tccttgcacc ctgatgatat gcaaaaaata catacctgct tctgacggaa tttaaacatg 190020 gactgttagc aagaatgtac ccttaaagtt ttgtaaactc tacagcaaag gaaaaaaaac 190080 tgctacagaa aaaataagga tttttttttc tagctttacc agtaacctat accttcattt 190140 cttcatgtta ctaattacag aaacttttag cagaaatgta tcactcttgg gcatcagcta 190200 gttctaaaca ttttagctct taggagcctc tggtgacaac tgttctgttg ttagttttgc 190260 tctctgacta gattgtaact tctaagctca ggaatcctgt cttcaactag ttctctttag 190320 tactaaccta accaagagct aggcatttag gaaatgctca ctataaatgt attgacaaat 190380 gattatgtgt aattagctct tcatcacaat atttttcatc atcaagaaat agatttaagg 190440 gagatatttt caaacagtat gtatatatca tccccttacc tttatgtatg tgtctgtttg 190500 tgaagtcagc acatattatg tgctaaactc aagaaactca agaaacaagg gaggttactt 190560 tctaagcctg catcatagca gtagaaattt ggaagaaaaa aaaaaaaacc catacaatta 190620 actgagttat aattaaagaa aattatatga ctaccaattg taatatttct aaaatatacc 190680 cacatatgcc aatctattgt aagaaaatgt tcgcagaggg aaaacaatgt aaattcctag 190740 aagctttaga tagattctaa tgattggaaa taagtattac aaatagtcca cattttaatg 190800 tgacttctag aatgttttgg aggtcatagt atccactcac gctcttatgc tgcttgctta 190860 caacatacac ttggttccca tttttctctt aggaaagatc atactaatga tctgtgatca 190920 tatttaccac ttggggatct tgctggccat gataaggaat ttggacttta ctctgattac 190980 gtgggaagcc actagagaat tttagccagt aaggtagcat gatctttatg ccttaaaaag 191040 gttaattgtt ttggtggata gttgttttag tagttaattg aaggaaggta aaagtggaag 191100 taggaagaac agttaggaat ctatttgatt gttcaggaaa aaggtgctgg gcgcatgggc 191160 tataataaca aaggagatgg agagaagtaa atggattgag atggaactga aagaacttgt 191220 tgatggttaa atacgaaaat taattcaaga tggattagag acttaaatgt tagacctaaa 191280 accataaaaa ccctagaaga aaacctaggg aataccattc aggacatagg cgaggacttc 191340 atgtctaaaa caccaaaagc aacggcaaca aaagccatag ttgacaaatg ggaactactt 191400 aaattaaaga gcttctgcac agcaaaagaa actaccatca gagtgaacag gcaacctaca 191460 gaatgggaga aaattgttgc aatctactca tcagacaaag ggctaatatc cagaacctac 191520 aaagaactga aacaaattta tgagaaaaaa acaaacaacc ctatcaaaaa gtgggcaaag 191580 gatatgaata gacagttctc aaaagaagac atgcatacag ccaacagaca catgaaaaaa 191640 tgctcatcat cactggccat cagagaaatg caaatcaaaa ccacaatgag ataccatctc 191700 acaccagtta gaatggcaat cattaaaaag tcaggaaaca acaggtgctg gagaggatgt 191760 ggagaaatag gaacgctttt acactgttgg tgggattgta aactggttca cccattgtgg 191820 aaaacagtat agcgattcct caaggatcta gaactagaaa taccatttga cccagccatc 191880 ccattactgg ggatatatcc aaaggattat aaatcatgct gctataaaga cacatgcaca 191940 ggtatgttta ttgcagcact attcacaata gcaaagactt ggaatcaacc caaatgtcca 192000 tcagtgacag actagattaa gaaaatgtgg cacatataca ccatggaata ctatgtagcc 192060 ataaaaaagg atgagttcgt gtcctttgta gggacatgga tgcagctgga aaccatcatt 192120 ctcagcaaac tatcacaaga acagaaaacc aaacactgca tgttctcact cataggtggg 192180 aactgaacaa tgagatcacc tggactcggg aaagggaaca tcacacacca gggcctatta 192240 tgaggagggg ggagggggga aggatggcac tgggagttat acctgatgta aatgacgagt 192300 tgatgggtgc tgacgagttg atgggtgcag cacaccaaca tggcacaagt atacatatgt 192360 aacaaacctg cacgttgtgc atatgtaccc tagaacttaa agaataaaaa aaaaatttaa 192420 aaaaaaatga gttggaggaa gttagagaaa gtgaagtgac aaagatgact cagaagtgtt 192480 tggcttaagt atctgagtgg atggtgaaac aattttcagg gataaagaag aatttagaaa 192540 gaatagtttt tttcagacat tagtcaagag ttctgtgtta ggattgagat gcctattgga 192600 taccaactga agatgctgaa gaggctgatt agagtctgaa gttcaatgaa gaggctcaga 192660 ctgaagatag aaatttggaa ccatcaacgt gtagatgata tttaaagcca tgagacttga 192720 tgagatgccc tttgcaagag aaaaaaaaaa aaagctacaa tattggaggg aagagttttg 192780 tgacaggaca atatttatgg gttaggcaga ggaggagaag cagtaaagga gaccaagaaa 192840 gaacactcag tgagctagaa gtgacagnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 192900 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 192960 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 193020 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 193080 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 193140 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 193200 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 193260 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 193320 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 193380 nnnnnnnnnn nnnnnnnnta ggcagttcat tttacacaca cacacacaca cacacataca 193440 ccaacacagc atttgctaca gatcctaaac ttgaagccct ggatcttcct tacatcattt 193500 acccagaggt atctttgtca acctttttaa cttataccca ccagaaagta gaacaaggca 193560 gaagttgtgt aggagttctg tccctccccc ctcacctcct ggcctcagca caataaatac 193620 tgtgttgaga acttggctaa ctgcttcttt tcccacattc gatcagggaa tacttaaagc 193680 catacagtgt ccctgttctt ccaaaaagca tatggggcag gttgcccctt caggctgaca 193740 caaagacaca ctgtgcaaga catctatggc cagtggagtg gccgtgtatg ttttatcaat 193800 gaggcttttg acttgtttct ttatgtcgta ttgtcatcac gttaaataga attcaaacaa 193860 ggaaacgaaa tttatattct agacttttaa ggcattgcct gccttatagc tatgaaactt 193920 tttttttcat acctggtata attttccacc ttaaacgatg ttgtgtgatt tgattatggt 193980 tttgactctc atttaattgt tcattttaaa atttttaact gaagttagat ttagatttaa 194040 agttcagtgc ccataaagga tacttctcaa tagagccaag aacttcagaa ggcacaacac 194100 aaaaagggca aagttcaaaa cactaagcat caggtaggta ctttattgtc cagggacttg 194160 tctaggtaga ctgtcacctt atccatcttc attcgctttc tagtagagct tccatcttct 194220 actgcaaaat agtttctgga accacttcca tgttgaccaa aagagagtgt caacaattcc 194280 tttccaaaat tgccctttag aaagtgaatc taaaatgttt gattcaagta tgtgagggta 194340 gctacatcaa agttttcttt tttactatgt acaaaagtga cagataaatc catgaaatat 194400 gtgcattttt ctgctaagac tgcttattaa tttaaaaaga ggttgttaga ataaaaggtc 194460 agagagtcaa catattacaa atatttattg agagcctgct gtgtgcagag ttggaaaaga 194520 taaaatgagg ttgctacttt caacagactt acaatctaat tgagggagca acaacataaa 194580 catgcaaagc aaataatgca agatacagca taagacataa ttaactatca gatgagtgac 194640 atatataata aataccatta attcaccagc aatcataatc agaagcacta tgtgccaagc 194700 attctgctca gtacttcaca tacattatat cattttttga aatattattt ctactttata 194760 gatggaaatt gcctctgatc ttccctcctt tctggagaaa gcaaggagaa tggtataagg 194820 tagacaaaga cctaagcaga tatgttggtc tggggcaaag ggtccgttta ggggaatgga 194880 gagaaatgaa ccctgggacc agcattagtc tgtttaccac cgtatcccag ggcctagtat 194940 tgtgccttgc acataatagg tgctcaataa tatgtcttaa aaaacaaatg gccctctggt 195000 ctgtgcctgt aacccagacc aagtaccatg gaataaagtt aattagtgaa ttaaagccac 195060 ataccacata gcctaaggac ccatccccaa gacctcccaa ttcccaacta tgacggtaaa 195120 ggatcgcagt ggaaaagata catcataggg ggatagcaat agcaattcca gcttactggg 195180 gcctatttta tggaatctga catggtgaac agttcataag tttatttcca ggcttcaaga 195240 ccctgcaaca tctggcctct tgcacctcca caacctcaaa tccttctatt cttccctcac 195300 tcgctctact cctgccacac acacctcctt tctactcctc aaatccattt cagggcctat 195360 attcttgctt cattttgcct ggaatgttct tccacaaaac atctgtgtgg ctcattacca 195420 taccttcaga tctgtaagag ccactctccc cacatcttcc cagctgcctg gcattatagt 195480 acacgtctat ttgcttatgt gtttgtcccc gtacacactg gaacatgggt ccagcgaggc 195540 agaattccat ctgctatttt taccattgaa tctccagcac ataggacaga catagcacat 195600 tgtaagtact cacacacagc aactcttaac tcaggattac tttttctggc tctgaaatac 195660 ctacttccaa gagaacgaaa tttattcaag aaatgttgga tggaaattga agagtgagct 195720 tggaaacggc agacagagtg gcaggagccc agaccaacct gtttatgaaa gatgcctttg 195780 cccataaagg gaaaaataca ccttaaagcc tctgccaaag tatatgcttt cttaggacac 195840 ctctgacatg ctgaatggca cctggtctga acaagaagat ctatggattt gccaaaacaa 195900 ctaattcctg ggacttaaga ataactacta ccagtatcat cctagtaaac aagtagcaag 195960 caacaagcac cacatgcaaa atcattcaaa tgccttcatg caggtgacag tcagtggaag 196020 aaattaatct tatttttatt attttttccc ttatcaaaca ctagcaaggg accagatgtc 196080 ataaacctag ttaaaatatg ttgactttac ctcaaatttg agtattcatg gttccaaaag 196140 gacacttgtt ataggatctg atgatgtact ttaaaatctt cttttgtgca aactgaggat 196200 tcagagacca caaaatgtat ggtaaattca aagtactatt ataagtaaaa tcataatgcc 196260 tcacgacatt tttgaaagta aaatatttag gaatattaca aatatgtatt gagcactccc 196320 tatatttaag gaactgtgct aatgctgtga tggatcaaaa ggagaatgag ccatgatcct 196380 taccttcaga cttcaagctt attattcatt gggcagttag ataactaaca tatcagacaa 196440 ggaataataa gtgccattgt ccagatatta aaaacaaaat tggtgttgtg gaagcacaaa 196500 gaatgcagag atggatccca actgggagaa agaaaaagtg cttcctaaag aagacgctca 196560 gattgacctt gaaagttgga tgcttttgca caggattaga aggtaggaag tcttcatttg 196620 ttggacttgc caattatttt ggtgtaaata ttcccactgt ggctgattta aagttgataa 196680 cgtgatgcaa ctgaacacag aattgggaag agaaggtggc tctagcacac tacctatgag 196740 tcaccatctg agctccaggc ttaattaaat cagcctcctc actactattt tgaatgagtg 196800 aaatcacaaa tcttaaaaac atctatgcta acattatcag agaagagata gtcacttcta 196860 tcattctcca ttacaactcc atctaacttt ctaatattct ctttgaatat ccttccaatc 196920 tcagtctcag tcatatgttc ctggctggcc tacctagaat taatcttggc acagtgccaa 196980 actgtgattc tgtttgttcc ttttagcatt gctgtgatta atctgcactc ctgttatcac 197040 atggcataga aaactctctt actgattatg gcctggtgtt gacacctctg ctgttctccg 197100 taatgaaaag cagctttcag ggtggctagc tgggcaggat gtttcgctgc tcttgtaaca 197160 gtaggaagga aaaactggag gaattactgg gaagctttgc agaaggaaga tacaggccag 197220 ccgagagcca gcattcctat tacctgctcc tttcagtatt ctttgtgaaa acaccaccac 197280 cagtgtgttc cctggacgtc actactgcac ctttaactgg ccttattatg ctagggacta 197340 cattagaaaa gccagactct agtatctgtc tgtaattgca agcggatgtc tcagcacatg 197400 cacaagctta tgtcaggagg atgtttatga aaaactcaca aagcagagca ctgctagaca 197460 ggaaataaat atgtgaagct tgaagttgtt aggaaacttc cacatttgtc tctctaagcc 197520 agagatagga cctgtgagaa aagaaggtct ttatcattgc acattgattc tcgttacctt 197580 gaagacttgc ttttctcaaa atacatttac agcaaaatgt ggccgctgca gatttattta 197640 aacatgtgct tttttctatg acactggttt ctcttccaaa tttgttatct attattttac 197700 tgtaaagcat taaaaagtgt ttgaaaccac cagcaccatt tcacagttcc tgtgttattt 197760 gtttaaattc tctagctcat gtaatatgcc gtatgattta ctgtttaagt atagaagaaa 197820 tacactccct catggagatg tggagatgtg gagaggtaat actgtctcct ggaaaggctc 197880 agagatttcc tgtttagatt acacaggctt ctttagagct gccaagagtc ataacatgta 197940 cgagataata cactttggtt caggagaaac tatggatggg aatgtaatta attcactgag 198000 ccacaaaaga aaggaaattc cagcgtagag ctgtcactgc actcaggccc ggtggacttg 198060 gtatgccaag gggtagccat gatcaaaaag aggattgcag cctgaggacc cactgagtag 198120 tatccaacca cagagcaaaa ggtgggggcc tggctgctaa gggtctcacc tggttctttg 198180 agaattgatc cctgaagcgt atttctgctc aacacttcag caacctggct tcatcagtat 198240 aactttccag aatgcttgtg acattgagat aaatcaatca gcatgtactt tatcaaatgc 198300 ctcctcatga gtaccaactg tggcacatag tggggaagcc ctagaggaag aacgctgaag 198360 aggatatggt gattctgatc agcgcaagaa ggtatagtga aaagtgtcct gaactgtgtc 198420 ttgtcataag aatcgcctgt cagggagggg tgtggaaggg caaggtaagc atacatattc 198480 tcaggacctt tccaaaatgt agagtgacca gggacctaga gattcagact ctgtcgatct 198540 ggaccaaaga cctagacttg gtatatttaa taaatgctgt gtgaggccct ttacatgcat 198600 tacctcctgt aattgtatag aacagttgct gtatatggta ctatgtttac ttgtatttgc 198660 actgtctatt cagggatgtt tcaaaatgcc attgctatcc aactggtgaa ttattattct 198720 tgccagaaca ttgattctcc tactcttgct cccttaataa tacactagag aactgggatt 198780 gactgcattt agtctcaggc tgaatgaatc attgccataa gtagatttcc atcccctact 198840 ccaccgatac atttgccaaa cactcttaaa gaatagaaac cactgcctac atacagcctg 198900 caccgggagg acctaaatag tctagctggg tttatgacaa tatcccatct tcacatcagc 198960 aaaaccctaa gtgcacaaag tctaatgtaa acacattaga ctccataggc atcttctcca 199020 taggaaaaga catgccccgg ctgtcaaggt agtggctagc aataataaca atgacaaaaa 199080 caataacaat gataaacatg tataacattt acttatcact aattgtattg taaatgaaat 199140 gattagcata tactaactga tttaaatctt atatatgtat agatactttt actctcccaa 199200 ttttaaacac agagaaacca aggcccagat acgtgtttct gttgggaagt tgagtacaaa 199260 gttgggtgta agtagggaaa gttcaactgc agtcggttct agtcttggta agtccactgt 199320 gaggtgctcc acctcaaagc atagcaaatt agtagttccc catgtttgca gaatcaaaat 199380 taagttcttt ggcaaggttc tccctgatgt gcccctgctt cttccctaac tcaacacatc 199440 ctcagctcca tctatgcact cccaacacat cacaactctt tatatgccca ggctgtgtct 199500 tctgtacctt tgtaccttct gcacctttgt ttctttagcc tcaactgccc tttcttttcc 199560 tctacattac cctttatccc aaatttagca cctgtctcaa ggagtcacct tccccaggaa 199620 gtttgtccaa atttgttaac agatattcca ttgttcctcc aatgcttgat ccttctttct 199680 ttatagatcc ctgcctagaa aactggactc actgaggcca ggggctgcag gtagtttatt 199740 ttataaccca gcatttaaaa gtgcctattt attgatttgt tgggaatagt taataaatgg 199800 agtccttgca gatcataacc aagagcacag tttgtaatgg tttcattaat tttgttacta 199860 ttggatgtga ttctctgctt atggtcttcc tttacttgtt tttcccttac tgctcagcac 199920 ctgtagatat taggtacatg gctctgacac taattaaaat tgatgactga gaatgacact 199980 tccatttgct aagccagcgc aattttgttc attgtgcttt actttttaac gagcaccctc 200040 tcagcagtag cataaatcta tagtctttcc atgagggtac catttgttcc ttttatgtct 200100 tgattcatta catattttca ggagtgtgag ctgattaaga gtttttggtt tgtgaaaatg 200160 tcaccaaatg cacgataaag gcaaagtcac cagatgtctg cttgcaaaaa aattaaatgc 200220 tggtttgtga agatccaagg ctggccaggg ctccccaagc atttccaggc ctgagctctg 200280 gctctacact ctccttaggg tctcataact gacccccaca ttccatttct gccatcatgg 200340 aaaaattcgt caactttact gctgatgtta ggcctggaaa ttgtcgtcca ttcgttttct 200400 cagattcaag ctgaaaatgg agacaaactt cctacgtaat tttgaccaaa ataacacata 200460 tgtttatgtg ctatcccata attaacatac ttttaaaatc actttcttga ggtatagttg 200520 gcgtacaaaa atatgtgcat atttaatgta tacagcttca ttaatttgga gataagtata 200580 catccatgaa attataactg catgtatgcc ataaacctat tacctacaaa agtttccttt 200640 cactttcttt gttattattt tgattaactt aatttttttc agccttcgaa ctatcaaaat 200700 tttctcaagt aatacatagt tgtcagttat acaaacttac tgaaccttga tcgaaggtcc 200760 tcctttagtg ctcaacttag agaaagaaat aatgaaacaa agtgttctct gatttgtagc 200820 aaagatctgt gatggtgatg ggaatggttc tagaaaataa tgataataat aaagacttag 200880 agtatcaaag cagcaagtat gtttgaagga attgttacaa tgcagttttg ctttctggtc 200940 actttaaaat caaggtgtag tactttattt actctaggaa aatgtttgct ttttgtcata 201000 atttcttatt gcatatgaga gtaaatgatc tatagatgaa gatattagta aaatttagag 201060 agagaataaa aaagaaacac tttcacagct gaaaggctgc ttcccagtta gctaactggg 201120 aggagttaat gaaaaagtac attaaaaagc ggctcgggga aggtgaattg gactcaccgg 201180 gctctgacat tcagagagat gggaatgagt cagctcactg tccagtacat ctttattttc 201240 tttctctttc ttgttttata tcagaaatag atttcttggc attgttactg tgggtttcta 201300 ttaaggactg aaacaaaagt attaataatc tgagagtatg tagaaaacaa aataaattca 201360 ctttctccca ctatactctc acaacacaga atattttagt gaccagagat caccaaaatg 201420 tgtgtggtgt tgaccaaaag agtcaaactc tgtaaaatat ttgaaaagat ttattctgag 201480 ccaaatgtca gtgaccatgg cccatgacac agccctcagg gggtcctaag aacaggtgcc 201540 caaggtggtc agggcacagc ttggttttat atattttagg gaggcataag acatcaatta 201600 aatacattta agaaatacat tggtttggtt cagaaaggca ggacaactca aacagggggc 201660 ttccaggcta taggtaaatt taaacatttt ctggttgaca attagttgag tttgtctgaa 201720 gacctgggat taatggaaag gaccattcag gttaatatat gtttcttatt ggacctaaaa 201780 cagtgcctgg ctcttagttg attattgcct ggatctggga aggaaggaag gaaaacaaag 201840 ggggaaggag atttgctata gaatgtggat ttttcccata aaagactttg tagggccatt 201900 tcaaggcatg acaaggaaat atattttggg gttaaatatt tttttccttg tctcataatg 201960 ttataccaga gtcagattga aaatcaagtc acaatataca gggtcaaata aaacccatct 202020 aatgagaacc cttggtttgt aggtcatgac tcccttgggt aggaatttgg gcaagataaa 202080 agattgaaac ttagtcctgg gtgggaatct ctctccacac aaattctcca acaggttctt 202140 caacgggacg ccaattgggt gttctctaat tcaattcaat tctgacagtc tatctatcta 202200 cctggaaata gcatcagata ccacaggttt agggctcagt ccaacaatac tgcccgtcac 202260 ttcagatgcc aattgcaagt aataggttgt tacctatact tctggccaat tagctgtaag 202320 ttggggttcc cacaacctcc tcctcaggtt tggtaatttg ggacagcttg cttacattta 202380 ccagcttatt agaaaggata ttacaaagga cacagatgaa gagatggata ggataagata 202440 tgggacttgg agttgcagag tttccatgac ctctctgagt gcagcatctt cccatgttca 202500 gctatccaga atctctcaca ttaagacatt ggccactggt gatcaaatta accttcagtc 202560 cctctcccct tcccagaggt tggagagtgg ggctgaactg tctcaacctc taatcaactc 202620 ttggtctttc ctgtgaccat cccccatcct gaggctctcc aggagccccc aggcgtcaga 202680 caactcatta gcatacgaaa aacacttatc actccagaga tgccaaggat tttaggaact 202740 gtcaagaaac agaaacaagg tcaaataggt atttcacaat atcaccagta gtttcactgg 202800 gaggtaaaac tcaatgttta ctgtgagcct gagctcacag taaagttatc taagttatca 202860 cagtaaagtt atctaagaat aacttagagg taacgtgatc agatatgggg aattctggag 202920 aaacaccttt cactaccaaa cccagacaag agatgcgtac ttttctagct gggatgctta 202980 caaagcaacc cattgtaata cttaaaggta gagtgacact acattcatca tttttcattt 203040 tttcctgttt tttatgccgc ctactactaa tgtcaatcaa attatgactg tgtttatact 203100 gatcatctca catcataaac ttgatcatct cacatcataa acttctgtgt ctctcatgtt 203160 gagcttttca cctcccttca ttccctccct acttccagga tcattcacat gttgatttct 203220 aaaaaaaact ttttttactg aacttatttt catactgttt aaaaagaatt tatatttctc 203280 ctcattctta caaataagat tcaagtttaa actcaaataa tgtaggaaat catttttttt 203340 aaaattgttc cctactgtgt ctaggcttga gaccacaggt aattaagacc aggttttcat 203400 ttgatatgat ttttatgagt tctttttaga ggttaggtag gttaggcaca atttttattt 203460 ttaaaaagcg ggttattatg agaggagaaa tcatactttg tcatttgaaa atgatgccat 203520 aagaggtgtt agcagaaaaa tcaaactgta aaatatttta gagatttatt ctgggccatt 203580 ataagtgact gtggccccac tgaaatgagt gagttccctg atcctctcac agagcatgcg 203640 acaggggtct ggctcacctg ttcagttgcc ccactgctca aacccctagg gggagaatac 203700 agacagtcag gtgcagaggc tggggcaagt gctttggccc cttagccctg cagtagtgtc 203760 taggggtggg gtgcccgcaa ccccagtgtt acaaagttct ttcagctttg cagtccacag 203820 acagctggag tgttaatcag ctcaatggac cctctgcctt atagcaaggg cagaaggcca 203880 gagtgacagc tttctgtatt ccaagctctt gcccagtgtc ctagaaaaat aagatcatac 203940 agggctcgaa ggacgagtgc agggttttac tgagtagtgg aggtggctct cagcaagatg 204000 gatggggagt gggaaatggg gatggattgg gaaggtgaac ttcctctgaa gtccagccac 204060 ccagtggctg gactcttcaa cctcccccag ccaagctcct ctcagcgccc agatggtcct 204120 cttctctctc tctctctctc tctgccacat catttcacca tctgtctgct ggtcagctgg 204180 cttgctggtg tgctggtctg ttggtctgct ggtctgcttc tggaacctgg gcttcagagt 204240 ttatatgggt gcaggatagg gggtgttttg ggccaaaagg cagctttttg gacatgaaaa 204300 cggaaatgcc tgttccattt agggttgcag gtcttcaggc ttgagggtgg gacctttgcg 204360 caggaactac cctcttctac ccagtgtttc cctgtctcct gtccatatca ccagtataca 204420 cagtctcaag gagtcctgag aaagtgtgcc caaggccgtc agattcagtt tggttctgca 204480 tgtttcaggg aggcaggagt tacaggcaaa aacataaatc agtacatgga aggtatacat 204540 tggttcagcc tgaaaaggca ggatatcttc aagtggggac ttgcagggca tagtttggtt 204600 cagagattct ttaatctgca gttggttaaa ggaacaaaac tttgtacaaa agcttagagt 204660 tagcaaaaag aaatatttaa attaagataa ggatgctatg tcagagtcag ccacaaaatg 204720 acctgtttag caagattaat ggcctacagg tgtgacttaa cccttgcctt gcatggccta 204780 aggtcttgtt tataatttag tatcttattg cccaaagagt ctattttgtc ggtcttatga 204840 tctctatttt aacattaatg ctggtcactt gtgactaaac tccaaagggg aggcatatct 204900 gacttgcctt cccattgtgg ccaggaaccc aagttttcaa gtttctctgg agtccccttg 204960 gccaagaagg ggtccattca gttggtttgg ggagctgagg attttatttt tagtttatac 205020 agggtcgtat gagattgtta ggacaggaat gactaatgtt ttcttctctt tctgtttcag 205080 ccacagcagc tatccttagc agagcatcct ggagtctgca aagtgttaat ccaggcctaa 205140 agacaagtaa gaatttcagt tctttttctt ccttcaatga tattttccat gttttagtgt 205200 aattaagcta ctatccttct ctgttttatt tgggatgtta gtaactggaa tagtgactga 205260 gatgaaattt tataggcaag caaaacattt tttaaggatt tgtttcttaa cttctgatat 205320 agtttggatg tctgtccctt ccaaatctca tgtcatcccc aatgttggag gtggagccta 205380 ggaggagatg tttgggttat gtgggcagat tcctcatgaa tggtttagca ccctcttctt 205440 tgtgctgtcc tcaccatagt gagtgagttc tcatgagatc tggttgttta aaagtgtgtg 205500 gcaccccctc ttcaatctct tgctcccact cttgccctat gagagacctg ttccacttca 205560 ccatgattat aggcttcccg aggctttcac cagaagcaga tgctaataca gcctgcagaa 205620 ctgtgagccg ttgaaatcat ttttctttat aaatcaccca gcctcaggta cttttttata 205680 gcaatgaaaa caaactaata caacttctct gcaaggctgc tttttctatt tttgcttatg 205740 cttagaggtt aagtaaggcc aaattaatga aggaggaaaa aagaggaaat gatacatcat 205800 ggatcaacaa ttatttattg aatttaggaa actgcctctt tttacaaatt ctttttaaaa 205860 ttattatcat tattatcttg aagtatttat ctaaggatta cattgataga aagttaaact 205920 tgtctctcca accagattgc cttaagcttc agaattatgc cttcttgtaa gctccttctt 205980 actcttaaaa tgactttaca cattcccccc tggtcctttg acaatctcct cttcagtcac 206040 aggacagaac cccaacatca actctgtggg gaagcttctc caaattctct aggcctgaac 206100 aattttctgc cttctctgct tccgtggaac tttgtccttt actacatgat agcgtttacc 206160 tcctgacatt ttagtgtgtt tgttagccct gcatatagaa ctcaccagat tgtgtggact 206220 gcatgaatga attaattcta ttgaacttta aggcaaagcc taaattttat gcttcttcta 206280 aatcccttac atctcctaaa aaaaattctg atccatagta gtaggtactt gtttaattaa 206340 attttaggga tggatgtttt tcatcagtgg aagtatatgc tagagtccat attatgcaat 206400 aagggaaggg aagacagagt acctaattca gttaagatat tgctattctt gttagtaatt 206460 ctggagtcat gaaatcataa tttgaatttt atgactaaat tgcagaataa atttccaatg 206520 tgagatttaa acattatttc cttggaggtg accaaaaagg agagttggta ctgtttttaa 206580 gaactgtcat tcaattgtca gttgtgccag agcacaaatc ctttatagcc ctcctgttta 206640 agaagcatct gacatgctaa gctgcttcct aattaacaca aaggttgtaa aagaagtggc 206700 tgtttggttg tgtttgggtt atcccagcca gtatattcca aagcttcctt cattcaacag 206760 atgagtgatc tcctttatat tctgtaagga aatgagaagt aatcagttaa acatgcatta 206820 ctaatgctac atgcttcaca ttgaaaccat cctcctgaca cataatactt taccctctgc 206880 tgtcccccaa agtggcagta ggatttctgt taagtcattt tctttattag gtcacaaggt 206940 ctaagaagcc taaacattgt gccttgttga aatataacct ctaggtatgg aggatgtgtt 207000 gaacaacttc ctaccagtca tttggcatat gttgatttcc tgtcttcatg atacataaga 207060 caactagcta attatcattc atatgtggta aatcacatag atactgactt cccctatctt 207120 tccagctttt tcttatcaaa agttacctgc tttctgtcgc aggaatgatt ggctaaagta 207180 acctatatca gggtctgtaa cagtgggcac ctatcagagt gcacatgctt gaacatatca 207240 tcgcctttat catcataagc ctcacatcca gatgtgatag acccaagtgc tcacatcccc 207300 tcactctgtc actgtatatg ttgttaccat atcacaaata tttaacaatc tgctgtgtac 207360 tcaaccttta gctgtatgcc ctgagggaga cagagtaaga tactgccctg acatcaagga 207420 gctcacatgc tccctaaaga gataatttca catgaaaagt tagtgtttaa catgaaatgt 207480 cctgagaata tacaattgta atttgcatgt ttcctatgtg tacttttcta agttctcaga 207540 ttcaaaacaa aaccccatgg aagaaaaaat gaaataaaaa ccctgtcagg acaaatccta 207600 gccagaactg accaaacata aaaaataaat gccactgccc tctccaagcc acctttactt 207660 tatacttggg tctaagaagc ccaaacattg tgccttgttg aaatataacc tctaggtatg 207720 gaggatgtgt cgaacaactt cctaccagtc agtgaagtgc agtgaccatt tagcagtatc 207780 tccttcctct ctctttccac ccgctgcccc atctctcctt ccttgcatct atcttctcct 207840 gccaacaata attttcttat gttctaagta aatatcttta atgctgtccc tactacctaa 207900 acattaaact tcaaaccttt cccaagaccc tgaacaccca ccccagcttg taagttcagg 207960 ctacttacct gggaatccca gacacactgt atattccctc ctctggtaca ctgctcatgt 208020 catcgaatct atcttcctcc caccccgccg tggattctgt aaatatatat cagtcctacc 208080 cacctttaag tttcagtcaa aacctgatac ttacggcctg aagcaatccc tctgttctcc 208140 atgctagtct atgagagagg tcatgatatt tcagtagctc tggagagaca catatggtca 208200 aaccagacca gctcaaatta acccatgcta tgcaccacct aaagaatcac ctcttgctgt 208260 aacctctttc ttcaccaaaa attatctgtc ccatttgcta agtaagccct tagggctttg 208320 ctgtgcctgc aacaggtctt aatccatgtg aatgtgcatt tttgtgttag tgagcacatg 208380 ctaacatgcc ttccacagat tagtttcttt agaaacattt tctggggaaa aaaaagatat 208440 atttttggtt agtaacccca aaaggacctt tcagttcacg tacgtgggta gcagcatact 208500 ccacttacgc aaaggtcagc ccagggtaaa tatgagcaaa aacacatact taggataaga 208560 agaatgttga gggagtttac agtttaaaga gatatccaga caacttttta tattttaaag 208620 aagtaatgct ataattttac tacaaagaaa acttcttttt gtttctgggg agaagaatga 208680 gaagagttac aatctcctag agaaaagcaa aacattttta gtactcccaa ataagacagg 208740 cacctcagct agggtgctgt agttgcacgt tctttgtgtt ttttcaagaa ttttatttct 208800 ctgtcatgat tatttattgg cagaggattt gatgagcatt tgggccaaat ttataagact 208860 ttcaacacat atggagaaaa aaaattagat gattgcacat ctttctgagg gagatttttc 208920 ccctgtttta aaagtcattg cttttcactg aatttatcat gtattcctat aaaagtgtaa 208980 attttgtgat tgatagcatt tttacctcaa aataaaatga atatccaaca ggagcaagtt 209040 ttattgactg cctgttggag cgtaaattag tctaaggttt catgaaatag gcatttgaac 209100 atgaatatta atggctgaga tcagaggcaa cttttgaaag gattccaaaa tattatcata 209160 ttagattggc acagcaaatg aattgcttga atgctagaag ttcacaaaca ttcaaacaat 209220 tgtgagttac attaacttca ataaaaactt ttgcaggaca aaaatttaat gtagtaaact 209280 tcatcttgct tgtccaggtc catatacatt cttagctgga ctcttgtcct agcttcctaa 209340 tttttcttcc tacctcctat ttttccctat tccaagccac catacttgct cttgattaat 209400 tcttcctgcc tatctctgat ttagtgattc atctgcccag tcatctatag tagctccaaa 209460 ctgttctcta aattatgaat aaacttatct ccctgacatt cagaaaattc tacagcattc 209520 atcttacaca cttttctagc cttatctccc ttttctcctt tgtactccta tgtttatatt 209580 ccctgcattc ttgcttcatt gtatccattt acattggccc ttttaccagt aatttcctct 209640 tctttcccct cagtctgaaa cagtccttca tagattttgt cctataagcc atatttcaaa 209700 tataacttta tccacaaagc tttgcccagt tacctcaaga gaatgcatgc ttctgcttta 209760 gaattgtagc ctttttttcc tctctcgcaa ggagagagtg tagcaccatg gttgaagtac 209820 tcagcctctg gagtgagctt tagtttaaga cccagttcta ctgcttactt gctatatgat 209880 cttatctaaa tttgataacc tctgtgtctt tttttttttt caaaataaag atgctaatag 209940 tacctacctc ataagattgt tgtgagaatt ataagtgttg atacatttaa agtagttaga 210000 atagtatctg gccctatagt aagcttacgt ggtatttatt gtattctctc atggctcata 210060 ttttattcca atgtgtatta aattgaactg tatgaaattg cccatgtcaa ctctatattg 210120 gaccctaaaa tcattatgtc atgtggttca accaaatgta gtgctttttg tacccccacc 210180 ttaatatact gaactatctc gaaagataag gactatatct tatacattgt tgtgtcctat 210240 ggtacctgct gtgtacctaa cacatgctga gtattttatg gatggttatt gaattttgca 210300 aatgacacac acacacacac acacacacac acacacacaa aatgcannnn nnnnnnnnnn 210360 nnnnnncaca cacacaaaat gcaaaaaaca aatagaagcc aagaccttcc cagtatctta 210420 agtactcttt ggctaccaca gagtttcctc catgtggttc agcagtcatt tatgaaagga 210480 gagtgataaa gatatacagg aggagaattt tatcttgtct attgctgagt ataaatacta 210540 tgcctttccc aaaagccttc cacagaacct ttccttcagg tcagggacct agtgtcatgg 210600 gtcggtcttg gataacattg caggacatat cagttcaact gccaagggaa tcataaatag 210660 tcctactcct gcctgtggcc caccactgcc tccatagaag gtacatgacc ctctctgctt 210720 tcattctttt ttatcagata ttttcaacat caagaactta ttagctgata atgcaactaa 210780 attaagtata acataaggga aatgtgtcct ggcagggatg gtatcttaga gtgaatgtac 210840 agcctttatt tgttacaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaac ttgagctttg 210900 gacaagcaat agggagcagc attgatactg ggttctgaca tggaagctga cattaaattc 210960 ttgacagtct gcttgtttat aaactattca gtaaacaatt tagtaagtaa acatagattc 211020 ttgctatctc ttttaaggaa agagtggtta tggtggcttt ctcttgtacc caacctagtg 211080 ctcagccttt cctgactcac ataagcacta atctccagat aacaccaaat gtcctagggt 211140 tattatttat cccccttcct tgttctctga aataagagga aggcaggtaa aattatgcac 211200 tttatgtaag aagaaataga ggtacagaga aaacagctta agtctcttaa cagcccaaga 211260 gagtgaagaa gatattgcca gtgcagtgag ttgtatctgt ccctaggtaa gcaaaatatt 211320 aataaaagca tacaactatg ttaataattc aaacagtctt tacttatatg gactttgcag 211380 tgactttttt ccagcctgaa atactcagat aatgactgcc attagtttca cacgttagtg 211440 ctttattata tactgctttg ctttcacacg aaattgttgg gagataagaa ttttatgtaa 211500 gataaatatt gggtcttaac ttttttatac cccttcaact tcaagcaatt ttctgagcaa 211560 tggtaagtgg taaatagata tttaccactt aagtttacaa gagacctgtt tctctctgtt 211620 cattggctta ggcactatta atgaaacctt tggaatgcag gtcccttctg gttgtaaaca 211680 tatatcgagg tcttctattt cttttggaac tcaaacaata agaaaataat tagaaatctg 211740 tgggcatagg tctctagaag ccttaatctt agaagtgagt aaaacaaatt tttaggccag 211800 gctcggtggc tcacgcctgt aatcccagca ctttgggaga ccgaggcggg cggatcacga 211860 ggtcaggaga tcgagaccat cctggctaac acggtgaaac cccgtctcta cttactaaaa 211920 attaaaaaaa ttacctgggc gtggtgacgg gcacctgtag tcccagctac tcgggaggct 211980 gaggcaggag aatggcgtgc acctgggagg cggagcttgc agtgagccga gattgtgcca 212040 ctgcactcca gcctgggcga cagagcgaga ttccgcctga aaaaaaaata ttttttttgt 212100 aaagcctagg aaggatgatt aagcatcttc ctaaaatttt cagtatgcct gtgtacactg 212160 tatatactga cttctagcat ggtttctttg ccaaagcata acacatagtt tttaaaggga 212220 taattcaaga ccaacattct ttcactctgg gtgaccccaa tgggtggtga acacctttta 212280 gtaactcttg aaagttaaag catccagcag ttggttgtga cctttttggt tgtgaccttt 212340 gagttattct agcttgtagc ccactgactt gctgctcagt tccacagctt caaaaccagc 212400 tctaatcact gctcccaaga gagccctagc ttctgcatac aggaggctct caccaggaaa 212460 ggatacctga agtccagaaa gacactctgt ccacactggc tcctccttgt agggaacagt 212520 tttttcaaat aatgtacatt tatgcactgg gaaaatatct tgaatttatt atttaggtgt 212580 aaccagactt taatacaact taacctacac actgggaaag cagactgtac accacattta 212640 caaaaagatt tatggcttta acaacgcatt caagtgtagt tactgctaaa tagcagttca 212700 agtaattgtg tgtctcatgg caaatatatg caatgtaagg taatatatat ttaaaccaaa 212760 aataacaaga ggtgattatt tgctaaataa agaacttatt acttaggaaa aaatgttata 212820 caactttcaa aggactttta aaaatataat atgatttata ggaaatttat ttgcgtataa 212880 ttcacaatgt ctggtacaaa gtaagctacc tctgtgtttt ttttttcttt aggtcaacaa 212940 atatttaaac caagggttgg caaactggcc ctcagaccag atgcttattt ttgtaaataa 213000 agttttattg gaccacagcc atgcctgttt atttcagact gtggctactt tgaggctaca 213060 gtggcagagt tgagtagcta agacagatca taggtccaca aacctaaaat ctttactctc 213120 tggccctcta aaaaaaaagt atgccaaacc attctaaaca gaaaaacaat taattctttt 213180 tttccaactt ttattttaga ttcagggagt acatgtgcag gtttgttaca tgggtcaatt 213240 gcatgtctct gaggtttggt gtacaaaaaa tccccttacc caggtattga gcatattact 213300 tgatgttttt caactgacac cccctcccaa tcttccccac tctagtagtc ctctgtgtct 213360 actgttgcca tctttatacc catgtttatc cagcatttag ctcctgctta taagtaagaa 213420 catacggtat ttggttttct gttcctgcgt taattcacct acaatgatga cttccacatg 213480 catccatgct gctgcaaagg acataatttt gttctttttt atggctgcat agcttttcat 213540 ggcgtatatg taacaaattt tctttatcca gtccaccgac aatgcgcatc tacgttgatt 213600 ttatgttttt gctattatga atggtgctgt gatgaatata tgagtcatgc gtcctttttg 213660 tagaatgatt tatttttctt tgggtatata cccagttatg ggattgctag gttgaatggt 213720 agttctgttt taatttcctt gagaaatctc cacactgttt tccacagtgg ctgaacgaat 213780 ttgcattccc acagcagcta taatatggtt gtttgtttgt ttgtttgaga cgggtctcgc 213840 tttgttgtct aggctggagt gcagtggtgc gatctcggct cactgcaacc tccgcctccc 213900 gggttcaagc aattctcctg cctcagcctt ttgagtagct gggattacag atatgcacca 213960 ccacgcccgg caaatttttt tgtattttta gtagagatag gggtttcacc gtgttggtca 214020 ggctggtctt gaactcctga cctcgtgatc tgcccccctc aggctcccaa atataatatg 214080 gtattttaag gaactaatca tcaagtttgt attggttacc atcttttagt ctcctgttat 214140 cttcagtttc ataattggca ttaatgacaa tatggtattc actttataaa tttgcttcat 214200 agtaaactct tctgaaataa attacagtca tgcatcactt aacagtgggg atgcattcta 214260 agaaatgcat aattaggcaa tttcatcatt gtgtaaacat gaagtgtact tacacaaacc 214320 tggttggtac agtctgctgc acacctagcc tgtatgatat agtctattgt tcctaggcta 214380 caaacctata cagcatgtta ctgtactgaa tattctcagc aattataaca caatggtaat 214440 tatttatgta tctaaacata gacaaggtac aataaaaata tggtattgta atcttatggg 214500 acgactatca catatgcagt ctgtcattga ccaaaacatc attatacagc acaagactat 214560 agttgaaaat tttaaattat atatatgggt tgcattgtat ttctgtttgc cgcattgata 214620 tatacattta atggtttgta tgtttgtact tgcattcata tacattaaac tgttacaggg 214680 agcatatttg cttgtgttaa aaaataaata atatttattt ctaatgactt ataaaattat 214740 tatggttatg tttaaagagg cttgaagagg tattatggtt atgtttgaag aggcgacaga 214800 aacatcacct ttgtcattga ccaaaacatc attgtgtggc tcatgactgt aatagtgtaa 214860 agtaaagatt aactgtattg gctaatcaat gtggacatat cattcagtat tactaaagat 214920 tctccatcca atgaagcctg aacacctgta aatgcttggt gatggatgga aagggcaatt 214980 atttgcagct ggactgtctg agacatgtca tcattattgc ataatattta tttaacgaag 215040 gatcaatgca ccgtacagct ccagtttgag ggcacacttg acattgtagt ttgtagatct 215100 tttataaact gactgctatc actgaagttt tgctgaagaa taaagacaaa agattctctc 215160 tttaggaaat tgtgcacttt aaagactcag aaacctgaaa cctcacagaa tcataataga 215220 tgtatttttc agagacaatt tctgagtcct tggcgtattc tcaaatgtca ttcatgtctt 215280 cactgccgca ggttatcttt ttatttttat gtgtcatgga aaagcagcct ttttcttttt 215340 ttctctctta ctatgcctta ataaatagaa tttaaaaccc caaatctgaa ttattgtgaa 215400 agccaatatt tgtagcaaat ccatctatgc tctgtgttgt cagcacatat ggttttgtgc 215460 acctgctacc atgaaattct gccagggtta tcctcagaga aatggagaga cacctgatgc 215520 catccttact gtgacagacg tttttctttc tgtgaattcc aaaaattttt gaagttatgc 215580 atctcttgca gtgaacttca gtgacttgtg tacacatggt atcttccttt ctagattgta 215640 agttctttga gggcagggac tgattctttc tcatctttat atgctctgct tctccactct 215700 tggtttagcc agagccttac acaaagtaga agcttaaata atgtttatta gatgaatatc 215760 atactgagtt ccagaaatta cctgagagca attgaagaag gaaagtgtgg agggagaggt 215820 gttagcatag agttcatagt gtctgagttt ggcatccttt tcctcaacac gaatactaac 215880 acagataagt aacctaactg tcttctcaaa tctgagagga gtagatgcat tttctctttt 215940 aggacttttc tatctcatgt gggaaaagca aacaagaagg tcctacaaaa gtcttgtagg 216000 tatttattct tatccgacag tggtggatgt gacaaactct cttattggtt tcagttggtc 216060 ccacaggtta tgtgatgagg actttggggt ttggggagct gggaaccatg agttgtctct 216120 tatggatgac ctaacatact gctaatacct gacaagcttc aatttatcca tctcgaaatg 216180 gagatactaa catctgtctc aaagggtcat tgtgaggagc aagtaggaac atagaaaatt 216240 tcctagcaca aagtagatat ggaagatagg gagtaagatg ttaggtattt tattgcttct 216300 actgcttctg ctgctgttac tactactgct attattatta ctactcctgg aagagtagga 216360 cttcctggga cactgaccct acttacccct tcaccttatt caccaaaact tatctcctat 216420 ataaattcat ttatattttt ctggaatgat aagaaaaatc cttcatctag gtagcatatt 216480 ttatatttga atagtttatg tttcaaataa ataaagtttt tacaaacccc agagaaggcc 216540 tatacagcca aatttgaaaa aaaaatttaa aaataaatat tcagtgtttc agatgtgtgt 216600 gtgtgtatct tttaattgcc atgtatttct accaaaaaat acaaaactta attttgtatc 216660 ctgaaagacc ctcatttgag aatccctgct tttatgttct gccatgacca ctttagtcca 216720 ggcaacagat agcttaggtt gttgctttac aagtggagaa acagggctga gaggctcgcc 216780 atactccaaa ttaccagtgc cagtcccatg gcacaaagac atgaaaggca ggcacccaaa 216840 cagaaaggta gtgcaattaa ttgcttcaaa gtcttcactc agggctgccc ttaggcatga 216900 tcagataaaa atgtacacat tgcttggcac ctggtaaaat gttgtttcct ttccttcctc 216960 cttcccctga tagactcttc ttaggtacag aaaagatgag gctgcacaca tagctaaaag 217020 ctatgccatt aaaacaaact tctttttttt ttttaattta tttattatta ttatacttta 217080 agttgtaggg tacatgtgca taacgtgcag gtttgttaca tatgtatact tgtgccatgt 217140 tggtgtgctg cacccatcaa ctcgtcattt acatcaggta taactcccaa tgcaatccct 217200 cccccctccc ccctccccat gataggcccc ggtgtgtgat gttccccttc ctgagtccaa 217260 gcgatctcat tgttcagttc ccacctatga gtgagaacat gcggtgtttg gttttctgtt 217320 cttgtgatag tttgctaaga atgatggttt ccagctgcat ccatgtccct acaaaagaca 217380 caaactcatc ctttttgatg gctgcatagt attccatggt gtatatgtgc cacattttct 217440 taatccaatc tgtcactgat ggacatttgg gttgattcca agtctttgct attgtgaata 217500 gtgctgcaat aaacatacgt gtgcatgtgt ctttatagca gcataattta taatcctttg 217560 ggtatatacc cagtaatggg atggctgggt catatggtac atctagttct agatccttga 217620 ggaatcgcca tactgttttc cataatggga atttccataa tgggattcca taactagttt 217680 acaatcccac caacagtgta aaagcgttcc tatttctcca catcctctcc agcacctgtt 217740 gtttcctgac tttttaatga tcgccattct aactggtgtg agatggtatc tcattgtggt 217800 tttgatttgc atttctctga tggccagtga tgatgagcat tttttcatgt gtctgttggc 217860 tgtatgaatg tcttcttttg agaaatgtct gttcatatcc tttgcccact ttttgatggg 217920 gttgtttttt tcttgtaaat ttgtttgagt tctttgtagg ttctggatat tagccctttg 217980 tcagatgagt agattgcaac aattttctcc cattctgtag gttgcctgtt cactctgatg 218040 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 218100 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 218160 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 218220 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 218280 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 218340 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 218400 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 218460 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 218520 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 218580 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 218640 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn ntgagcagtg gtttgtagtt ctccttgaag 218700 aggtccttta catcccttgt aagttggatt cctaggtatt ttattctctt tgaagcaatt 218760 gtgaatggaa gttcattcct gatttggctc tctctttgtc tgttactggt gtataggaat 218820 gcttgtgatt tttgcacatt aattttgtat cctgagactt tgctgaagtt gcttatcagc 218880 ttaaggagat tttgggctga gacaatgggg ttttctaaat agacaatcat gtcatctgca 218940 aacagggaca atttgacttc ttcttttcct aactgaatac ccttgatttc tttctcttgc 219000 ctaattgccc tagccagaac ttccaacact atgttgaata ggagtggtga gagagggcat 219060 ccctgtcttg tgccagtttt caaagggaat ttttccagtt tttgcccatt cagtatgata 219120 ttggctgtgg gtttgtcata aatagctctt attattttga ggtacattcc atcaatagcg 219180 aatttattga gcgtttttag catgaagggc tgttgaattt tgtcaaaagc cttttctgca 219240 tctattgaga gaatcatgtg gttcttgtct ttggttctgt ttatatgctg gattatgttt 219300 attgatttgc gaatgttgaa ccagccttgc atcccaggga tgaagcccac ttgatcatgg 219360 tggataagct ttttgatgtg ttgctgaatc cggttttcca gtattttatt gaggattttt 219420 gcatcgatgt tcatcaggga tattggtcta aaattctctt tttttgttgt gtctctgcca 219480 ggctttggta tcaggatgat gttggcctca taaaatgagt tagggaggat tccctctttt 219540 tctattgatt cgaatagttt cagaaggaat ggtaccagct cctccttgta cctctggtag 219600 aattcagctg tgaatccatc tggtcctgga ctttttttgg ttggtaggct attaattatt 219660 gcctcaattt cagagcctgc tattggtcta ttcagggatt caacttcttc ctggtttagt 219720 cttggaagag tgtaagtgtc caggaaatta tccatttctt ctagattttc cagtttattt 219780 gcatagaggt gtttatagta ttctctgacg gttgtttgta tttctgtggg gtcggtggtg 219840 atatcccctt tatcattttt aattgcgtcg atttgattct tctctctttt cttctttatt 219900 agtcttgcta gtggtctgtc aattttgttg atcttttcaa aaaaccaact cctggattca 219960 ttgatttttt ggagggtttt ttgtgtctct atctccttca gttctgctct gatcttagtt 220020 atttcttgcc ttctgctagc tttcgaatgt gtttgctctt gcttctctag ttcttttaat 220080 tgcgatgtta gagtgtcaat tttagatctt tcctgctttc tcttgtgggc atttagtgct 220140 ataaatttcc ctctacacac tgctttaaat gtgtcccaga gattctggta tgttgtatct 220200 ttgttctcat tggtttcaaa gaacatcttt atttctgcct tcatttcgtt atgtacccag 220260 tagtcattca ggagcaggtt gttcagtttc catgtagttg agcagttttg attgagtttc 220320 ttagtcctgg gttctagttt gattgcactg tggtctgaga gacagtttgt tataatttct 220380 gttcttgtac atttgctgag gagtgattta cttccaatta cgtggtcgat tttggagtaa 220440 gtacgatgtg gtgctgagaa gaatgtatat tctgttgatt tggggtggag agttctatag 220500 atgtctatta ggtctgcttg ctgcagagat gagttcaatt cctggatatc cttgttaact 220560 ttctgtctcg ttgatctgtc taatgttgac agtggagtgt tgaagtctcc cattattatt 220620 gtatgggagt ctaagtctct ttgtaagtct ctaaggactt gctttatgaa tctgggtgct 220680 cctgtattgg gtgcatatat atttaggata gttagctctt cctgttgaat tgatcccttt 220740 accattatgt aatggccttc tttgtctctt ttgatctttg atggtttaaa gtctgtttta 220800 tcagagacta gtattgcaac ccccgctttt tttgttctcc attttcttgg taaatcttcc 220860 tccatccctt tattttgagc ctatgtatgt ctctgcgtgt gagatgggtc tcctgaatac 220920 agcagactga tgggtcttga ctctttatcc agtttgccag tctgtgtctt ttaattggag 220980 catttagtcc atttacattt aaagttaaga ttgttatgtg tgaacttgat cctgccatta 221040 tattaactgg ttattttgct cgttagttga tgcagtttct tcctagcctc gatggtcttt 221100 acattttggc atgtttttgc aatggctggt accggttgtt cctttccatg tttagtgctt 221160 ccttcagggt ctcttgtaag gcaggcctag tggtgacaaa atctctaagc atttgcttat 221220 ctgtaaagga ttttatttct ccttcactta tgaaacttag tttggctgga tatgaaattc 221280 tgggtttaaa attcttttct ttaagaatgt tgaatattgg cccccactct cttctggctt 221340 ggagagtttc tgccgagaga tctgctgtta gtctgatggg cttccctttg tgggtaaccc 221400 gacctttctc tctggctgcc cttaagattt tttccttcat ttcaactttg gtgaatctgg 221460 caattatgtg tcttggagtt gctcttctcg aggggtatct ttgtggcgtt ctctgtattt 221520 cctggatttg aatgttggcc tgccctacta ggttggggaa gttctcctgg atgatatcct 221580 gaagagtgtt ttccaacttg gttccatttt ccccctcact ttcaggcacc ccaatcagac 221640 gtagatttgg tctttttaca taatcccata cttcttgcag gctttgttca tttctttttc 221700 ttcttttttc ttttggtttc tcttctcgct tcatttcatt catttgatcc tcaatcgctg 221760 atactctttc ttccagttga tcgagtcggt tactgaagct tgtgcatttg tcacgtattt 221820 ctcgtgtcat ggttttcatc tctttcattt cgtttatgac cttctctgca ttaattactc 221880 tagccatcaa ttcttccacc tttttttcaa gatttttagt ttctttacgc tgggtacgta 221940 attcctcctt tagctctgag aaatttgatg gactgaagcc ttcttctctc atctcgtcaa 222000 agtcattctc cgtccagctt tgatccgttg ctggcaatga gctgcgctcc tttgccgggg 222060 gagatgcgct cttatttttt gaatttccag cttttctgcc ctgctttttc cccatctttg 222120 tggttttatc tgcctctggt ctttgatgat ggtgatgtac tgatggggtt ttggtgtagg 222180 tgtccttcct gtttgatagt tttccttcta acagtcagga ccctcagctg taggtctgtt 222240 ggagattgct tgaggtccac tccagaccct gtttgcctgg gtatcagcag cagaggctgc 222300 agaagataga atatttctga acagcgagtg tacctgtctg attcttgctt tggaagcttc 222360 ctctcagggg tgtactccac cctgtgaggt gtggggtgtc agactgcccc tagtggggga 222420 tgtctcccag ttaggctact caggggtcgg agacccactt gagcagggag tctgtccctt 222480 ctcagatctc aacctccgtg ttgggagatc cactgctctc ttcaaagctg tcagacagag 222540 tcgtttgcgt ctgcagaggc ttctactatg tttgttattg tttactgtgc cctgtcccca 222600 gaggtggagt ctacagagac aggcaggttt ccttgagctg ctgtgagctc cacccagttc 222660 gagcttccca gcagctttgt ttacctactt aagcctcagc aatggcgggc gcccctcccc 222720 cagcctcgct gctgccttgc cggtagatca cagactgctg tgctagcaat gagggaggct 222780 ccctgggcgt gggaccctcc cggccaggtg tgggatatga tctcctggtg tgcctgtttg 222840 cttaaagcgc agtattgggg tgggagttac ccgcttttcc aggtgttgtg tgtctcagtt 222900 cccctggcta ggaaaaggga ttcccttccc ccttgcgctt cccaggtgag gcaatgcctc 222960 gccctgcttc agctctcgct ggtcgggctg cagcagctga ccagcaccga tcttccggca 223020 ctccccagtg agatgaaccc agtacctcag ttgaaaatgc agaaatcacc ggtcttctgt 223080 gtggctcgcg ctgggagttg gagactggag ctgttcctat ttggccatct tgctccgccc 223140 ccaacttctt tttcaaagag caccttcacc ccttactgga ctaaagtcaa tccgaagctc 223200 ttttctctaa gctttataac acttactgcc tggatgagtc atttgtcaat aatacagact 223260 atttgtattg gtgggtttct tgtatatatg tacgagcccc tagagtctct aacttaaaat 223320 ttatttttgc tttagaagtt caggattaag gaggctatga tgatcaattt taacaacctc 223380 aataaataat acagtaacta atggttaggt atccaggcta gcccagggca gcctgtgtga 223440 ttcatgctgc tggtgaactg tggctggctg ggtaaactag atctgaaatt ctgtggtgcc 223500 taagggaggg aagggaatat ttcccacact atctcatcct gccctcacta tccctacccg 223560 caatctctct ctacactcta ccccacctac cctgcttttt ctgtgaaaga ccagctgggg 223620 caaatatttt ggattaagta aaatttgtct tgggtaactt cccaaaaatt tagtttttaa 223680 ctgaataatc ttggttaatc catgagtaaa taaccttgta gactatagtc agcctcactg 223740 tgagaagctg acaaattaga acaccagagg aatatacacc aattccttcc tgccctgcaa 223800 acctctgctt cttgaggttt attaagagtg ggtgcctcgg ccgggcgcgg tggctcaagc 223860 ctgtaatccc agcactttgg gaggccgaga cgggcggatc acgaggtcag gagatcgaga 223920 ccatcctggt taacacggtg aaaccccgtc tctactaaaa aaaaaataca aaaaactagc 223980 cggccgaggt ggcggacgcc tgtagtccca gctactcgag aggcggaggc aggagaatgg 224040 cgtgaaccca ggaggcggag cttgcagtga gctgagatcc ggccactgca ctccagcctg 224100 ggtgacagcg cgagactccg tctcaaaaaa aaaaaaaaaa aagagtgggt gcctcattga 224160 ttagtcatta gttattgaca gaaccagaga gatatgcctg gctcctcttg gaaaaaacca 224220 aaagactgaa agggaaaagt acatcagaaa gatacccaag gaggcagact gctataagga 224280 aaataattag gagaagaaat catatgtttt cagatgaata gaatctgggg atgaaaaaag 224340 cagccttttc aggcagatga tggaaagata gaaactaaat tcagaaggat tagaagatga 224400 ttagaaggac aagaagccac agaagaccaa gatttctcaa attaccaaaa gaaggtaagc 224460 ctagccttgt tcagtctgca gaatgagaac tcccttctag tagatccgta caatgaattt 224520 cacaaaggtt gatttccctc tctcctcttt gagcccataa tcacctcctt ctacgtgcac 224580 aaccttgacc atcaccacta cctataacaa ataaccagtt cttatgatcc cctcaaggca 224640 taacacaaaa atattttctt tgtgattact ttctctacac aaaagagaga gagagagaga 224700 gagagagaga gagagacaga gacagagaca caagtcaggg gacttcgttg gtgagtttag 224760 accacagcaa gaacctaaaa tcctagtggg ttgtcaatat agacaggctg aaaccactaa 224820 gatcctgagt ggtggttcta ggtaggtatg cccatcagaa ccatctgtgg ataagtattc 224880 tcagtaaata cacatgcagg acctctacct cagatgtact gaattgaact tcactgctgg 224940 agctcaggca tttcatattt gtttcctaag ctgctataac aaagtaccac aaacttgatg 225000 gcttaacaag agaaatgtat tctgtcacag ttctggaggc cagaagtcca aagtcaaggt 225060 atgaccagga ctggttcctt ctggaggctc tgaggaaaat ctgttccaca cctctctcct 225120 aggttttggt gactgccagc aatctttggt gttctttgat ttgcagaaac atcattccaa 225180 tctctggttc tgtcttcatt tgactttccc tatgtctgtg attggtctcc tttctgtctc 225240 ttataaggac acctgtcact gaatgtagag cctatcctaa tgcacaagga gctcaattat 225300 accttaacta tatctgtaaa gacccttttt ccaactaaag ccatattcac aggtaccaag 225360 gtttaggact tggatatacc tttggaggat acagttcaac ccattataca tatgtattga 225420 agggaaaaat tcacaccaca actgattctc ctgtaaagaa tgttggcctt aatgcattta 225480 acacaccatt tctccagcac ttaggaaatg ctaggacatg caaagctaaa gctaaatagg 225540 cttctttatt gcagaacctc tcagaggctc tcatctgttt gtgtgcatta taaatgtcca 225600 agagaaaaaa aagaaccata acatttcctg gaaatagtcg accagggaac gtcttttcaa 225660 gggattacct attaactacc tcaatggaca ctaatgacta aaggaataca ggctgctggt 225720 gattatggca cttccaaagt atgctcaatg gtgtgggcat gagtctacca cagtgtataa 225780 acacttagag tgttaatgtc tacactgacc tctccctgga tatgagcaca catccttcat 225840 caaatatcca cagtggtttc cctagaggat ttgcatatgc gcatggaatt ttagatgtct 225900 agtctctact cttgccttca gccatttttg tagagagaaa ttggcaaaat attagcatgc 225960 atggaaggga aaggtggcca agataataca ttatgccttt ttttccccct gaaaattgcc 226020 cagaatatct gaaaagggag aagtggctta atcatttcta ttcccacaat tctgatccta 226080 caaaattgat atcagtatat gattcatcca gaagttcaca gtggtatttt tttaaaaaac 226140 acttttagag gttaccaggg catctcactg ttttaaaatt taatacctca agggaagtaa 226200 gcaactacct tgaatttttg catgaattgc attcaagaat aactgaatag ttcgtggaat 226260 aaagttgatt ttttaaaagt aggcatattc tagttaataa atgtaaaaga aatggtagga 226320 ttacaaaatc actacattac aaactctaat gacataatag atttaagcaa aatgatcagt 226380 gaatgataaa atatttaggt atgctctctt ccaggtgaat caagctgaca ataccttgga 226440 cccacattag tcttaccaca tgatattata tgtctcctga tacttaaaat aaatatcaaa 226500 taaatgttga taattgttga aacttggtga tgaacatata gttcacagca ccacccgtga 226560 tggattcttt ccatgagaat tgatctgaat caaagcaagc ctctcggtct aactgccagt 226620 gtataggaaa taaggataca gtaacatttt taaagtcttt aagaatgcag taagctgaaa 226680 gaaattggtt tctgcaataa cagcaacaaa attatgtaat aaaaagagag agggagaatc 226740 atggatttat acaaacttaa gagacgttgt gttaatctaa tgtgtatcct gatcaaacaa 226800 attaactgtc aaaagatgtc ttttgagata tgttaggaaa tttgaacata aactaggtat 226860 tctatgatat tcaggaatca tcgctaattt gttagatacg acgttggtat gatttttttg 226920 aatgagaaag tttttagcat cactaatttg ttagatacaa tgttggtatg atttttttaa 226980 atgagaaagt ttttagcttt tagagacaca tacctagata gttatggatg aaagcatgtg 227040 atttaaaaaa aaaaaaaaga tagtggaagt acacagaaca ggattgctaa atgttgataa 227100 ttgttgaacc ttgatgatga acatatagga attaattaaa ccatattttc tatttttttg 227160 tttattttgc aaattcaaaa ataaaaatag aataatccct catgaacaga tggcctcaac 227220 tttcatcccc aagtaaacac aattcacatt ctcagtggaa cccatgagaa tattatgaag 227280 tatatgtcta tctcatttca ttatatatgg aatcttacca ttccctttgt ctttattact 227340 agtggccaga gttctatctt gaaatgtggg aaatgtccta tatgaacaaa ttagtttaat 227400 tactgtgaga aaaccagaaa atatttgagt tctagctaac tggatattga atgagttgtg 227460 ctgaagtatg tggtcctgaa gggttgataa tgaaatattt gctttccagt ggcaaggaaa 227520 aataaatgtc ttagctagaa tttacaaggt cattcttgaa atcaatcaac ctgggctgaa 227580 gatttcattg ctgctgttat ctggcatgat ggtattgttt gtgcacagtt ctgttgatgt 227640 gagctatcaa atatttctta gaactgaaat catataatag caaacactgc tatgtcccaa 227700 tggagattcc aagactcttt taccatggaa catttacatt ctatcccctt tcatcactgc 227760 tgaacaaaca aaaacaaaaa aaggaaagat aaccaataag ctttttattt aattgaaaac 227820 caaagagaga gagaggaaag aaccagttag ttgccatttt ctaaatgcag acttttgttt 227880 ctttctgcct tccaattctt tgctcttgaa gctatagctt tcaagcttgt gtataaaggc 227940 ccagagagaa catttgaaat gtggccaccc tacccatgtc catgccactc ttcctgcctt 228000 tctctctgcc tacttctgct ccaccatccc aggtcagggg ctgggaggct gatagcatta 228060 caagtagtat agtcattcaa gctcatataa acaagatgaa atccaaataa taacaaaaag 228120 tattttattt caagtactac tcagttcctt cagttttgct gaccgatttc taggagacct 228180 aggctcagct cttggttgtc tcagaactga ggacagtact catttgcacc atatgcatct 228240 gcttgttagc ctatgcaacc aaaattgatt cattacttgg ccttctctga aaagaaaaat 228300 gaaaaaaaat gcactcttaa aaataattct taaaatacaa ccaggaggca tgtgcctaga 228360 catggctcac cttccaccaa atcatacttt atgatttccc acaatgttac cttctattcc 228420 tcctgcccct aaggttctat ggagcagagc aggttgaaga atgttaaggt tgtactaaac 228480 tttttagaat agaggctttg gggaagcaaa tgagaggtac actgaaaatg aagtatctgt 228540 ctctgctcct attaatgtca caggactaga agttgacctc atagctgatt agagatggac 228600 cctgcaaatt gaaccccagc acatgcctct cattatccat tcttctcttt gcagaatggg 228660 gtccatgctc acatatcaag aaaatggtgg gtttcagtct ggctcactgg gtgaggtttt 228720 ggcatgcaaa ctaataagag ttagtgtaca tcacccataa taaaagtaaa agctttattt 228780 ttatttcccc aggtaaataa gcaaaagaca gatctaaaat acattagagt taagttccat 228840 ggggacagaa atgtctgctt tgtttgttgt tgtatatttg acacctagaa tggtggctgg 228900 accatagtga ctacaaataa aatatttcct aagggaatga atggttctgc aggatagatg 228960 ttctctgcat ttggataagt gatgatacta tagactcaga gcctagatag aaaatattgt 229020 cccactttca gttctgcaag ttgacttgag gtgcttggcg atgtcctgca gcaagcaaac 229080 ccaatgaagg catctctgag accccgtagt caccaccgct agcctcccat taccttgccc 229140 accctagatt ttcaaattgg gaatcattgt ggtaccagat tgggaatatt tgacttgcat 229200 actttctcat attggggctt aggattttga gatcttactt ccttttttgg cttcttgaga 229260 tctgaaattg ttgttcagag aagcgtatta agacaatgat tcttccatta ccatgcattt 229320 ctgttaccaa cagaggaggt aagtgaatca cttaaaatga tacaattcca tccacttcag 229380 tacgctataa acatatcctt agctttgact ataattatag tatgtgggtg atgctgctga 229440 gaaaatggta taattataac attatggttg agaattgtct gagtagaaag cactgagctg 229500 tactatgcaa agtttaaggc agcattatgg gtcccttttc aatatgaata aaattgatta 229560 gccaattgca actgagagct ttgtaaaatg atattaataa tataaaaatc agctgggcgt 229620 agtggctcac gcctgtaatc ccagcacttt gggaggccga ggtggtggat cacaaggtca 229680 gaaaatcgag accatcctgg ctaacacagt gaaacccgtc tctactaaaa atacaaaaaa 229740 ttagctagct gagtgtagtg gcgggcgcct gtagtcccag ctacttgggg gctgaggcag 229800 gagaatgccg taaacccggg aggtggagct tgcagtgagc tgagatcatg ccactgccct 229860 ccagcctggg tgacagagcc agactgcagt ctcaaaaaaa aaaaaaaaaa aaaaaaaaaa 229920 aaaaaaaaaa aaaaaaaaaa aaaattcagg ggccaaggta aaaatttagg aaaaatttga 229980 tacttttaat ttcttttact tataggagtc ttgtatgcaa ccctaatgca aagtaaagaa 230040 gctcaccaac ttgaaggaag catgaatgaa attacaagga aaagctagct taaaaaaatc 230100 aaccctgtta cttggttttt cccctctttg ctcttggcaa aaggatctta catatgtata 230160 ccaaatgtct atttgaaaat tttgtttccc tgaatataga tttcttttct ctttaacaga 230220 ctgatccaat ggttgtagat tttatgctac cataaattaa agaagacagc attctatatc 230280 atgactgagg tgttaatgac attatgcagt tgtcacattt tgaaatataa acttaaatgt 230340 gagcttttca ctgtgtgtaa agtttatctg tattaaaatt ttttttttaa ataccagaga 230400 tttcagcaac aagaaacata aagaagtaaa aagtacatag aaaccctgtc ctagaggacc 230460 tgttccgcca cttaaaagcc atgtacctct tgaagcctgt ttcctttatt tccaaaatgg 230520 gaatttttat atttacaccc taaccatcac gtgggtcaca tgtgataaca atgtgcaagt 230580 ttcttacaag tgttctagaa atctgtaagt cttagagttc tgaggtttac tcccaaagaa 230640 gtggaaattg tgggttgcac caaacagtta aacagggtga cagggaaccc ctgtcacgta 230700 cccaggcctt tgggttattt tctagggtga gggaacatgg ccagtagtac aaagcatgtg 230760 agtgtgtgga tgtgggtatc tgcagtggat gagtgggtgt gtatgtttat gtacaacaca 230820 tgtgttggag gataaaaggg aaaataattt gtctttgtga cttcatctct attcctggct 230880 tggaatgtta ttcctctcta cacaaagcat caaaacagaa accccttccc ttctttatta 230940 tatcggaaat ctggaaattc agttatcctt gtcttatcct actccctgct ctgttctaaa 231000 tatataataa taataataat aagtaatagc actagtagta gtagtcgtcg tcatcgtagt 231060 agtagtagtg gtcgtagtag tagtagtaag agaatgaaga gatggaggag aagaattgga 231120 aatagggagg tttcctgtac ctgactggca gtttatatag caaccgcctg cagatttagg 231180 tcgtttctta cttcgcttat tttacagcaa cctcaaccaa ctgtgacaac ctgcaatatc 231240 tttagccctt aagatactgt ctcttaaacc tgaccaatat ttcttatttc tcaaagagta 231300 atgacaatct tttctgtctg agaacttcta aagccacaat tgattttcct cacatttccc 231360 tcaaatgaaa ggagtatttg aaaaatggaa ctcaaaggag gagccacctc agaagcctaa 231420 ctggagcagt cagactctgc atcaacagac ttggcttcag ttctcacact gatacttact 231480 agctgtggga tttttggaca agtcacttaa cccctgagtc tttagcttct catctgtaaa 231540 caagtataaa tactacctac ttcataagct cgtatgaaaa ttcccacaaa gtatgatgtt 231600 agtttccttt ctttttgtgc tcagctctaa aaatatgcag tgtagtaagt catcaatatt 231660 tcattaacat aagggaaaac tatataccca acccaaaagc tgagattctt cagaacattt 231720 tttttaaaga gattctaatt gggaatttta taaatggaat acagagtact ttttaaataa 231780 taataacaat gattaattta aagttactaa acaaaatacc ttaatgaatt tgggaaaaaa 231840 taagctaaag ataaatatta agcaaaagag aaaattatta aagtaataat gtacaagtca 231900 cttgatactt gcaaagtaac acagaattag acataaagcc acattcaaga ggcagcaaag 231960 ccaaaatggc tggctggccc cgtttgaaag gctcttggca acagacatac ggaaaactct 232020 catctctttc ctgggcctta cttcctactc tggataagca gcatctttca cacaaaagaa 232080 catatccaga ataactaaga aagagatgaa atgatttatc ggaactagtt aaaataatta 232140 aatcttaaaa gcatgttccc ctggacatag agtggggtga tttctgcaaa gattttgaaa 232200 ataaagtacc cctaaaacaa ggatttggtt taactgcttg aaaacaatgt gacaggttga 232260 gaaaactgaa aattttctta aaatcttgtt tacttgaatg gtgagccagc catccagggg 232320 agaaaccaga gctctttcct taaagaaata cagacttccg ttggaagaaa aaagttggta 232380 ggttttaacc ttcaaccttc tagtgaagtg agaatattga ttgagcatct attactagaa 232440 taaatttatc ttaagtgacc cagggaaggg tcatgggtga taggaactgt cagagagaaa 232500 aaaaatacat ggttgtggat cttaagtact tacaatctac tgagggctct tgtctgcatt 232560 ttccttagat cgtgatgttg ctcaaagtca cataagaaag cacataaatt tactgaataa 232620 tattaagaaa gcagcagtga cactgaaatg cttgcattct gttcactatc ccagtcatct 232680 gcagttgcct gggggatttg caagcaagga caggaaaatg ctagtaccaa ccagttctag 232740 ataatgaatt tatttgctgc aaaaactttc actgtattaa attaaattag attgactgga 232800 attaaaaggt aataaggccc attttcttat gtaggtcatc aattacttta actctaaaga 232860 taattccaaa agaagaggtt taaaaatcgt ttgagtagta gtaacatcat tggaatttat 232920 ttgaaacttc ccaatgtgct cacttttaca gataacatat gtatatatat atttttatat 232980 atatatatgt atatgactgc tggcataatg attaaaatga tcagttttat tactttgtaa 233040 tcacatcaag taacaccgat gattgaaata aaatctgtta gatgagtgaa tgcaatgata 233100 atgtatagca gatgaaagtc tttgctatga agcacatgat tgttgtaatt gttgctgctc 233160 ttttgggatc ctgaaccaga ttccccaaat aagtaggtaa cacggcattt gtcttgagca 233220 ctttttcaag cattgtaatc catgcattga agtagacatt atcagcctac agctgtaaac 233280 tctaagatga ttttaaagtc tgaaggttta taggtcttca ttaggataag ctgggctcac 233340 catataaatc cttgaggact ttgctagaaa aatagtggaa ttattgaata gggaaaagag 233400 ataatggtaa tgggatttgc ctgatgtctt catcctagaa aaaaagattt ctgcttgggc 233460 attaagaatg atgattctgg aagactttca ggaatgttga taaggcttga gttactcagg 233520 atttgatgcc aaagaagcca cactgcacat gtgttcctct aaggtgtact tggttctcac 233580 ctgagaggca aaggctctac ttattttttg attgtttggt cctaagttac cttcaaactc 233640 cacttaaccg catctctaat cctgcgtatt gcctttccag catcttgtaa attccaaggg 233700 gttgggggaa cctctaggtt ccaaggctaa gctaagttat aaatgaatac cctgtgcagt 233760 gttgagaatg aaacagaagc tttggcgcat ggtagcccac tatgaatgcg gtttcagagg 233820 agcagtccag gcgccctcaa tgaataggca tatatgggcc aagagacagg cctctcagcc 233880 ataccacagt atactggaac aatgagaaat gggagaggac atacttctta cagtgacaca 233940 ctgacctgtt ttcattctgt cctctctctg cttctccatt tccacttatt gcctgtattg 234000 catctgtcca gtaactgttt ctttaacagt tttccagact gacattatta atccagaaga 234060 tggatggtag tttttttgtt gttgttgttg tttgtttgtt ttgttttgtg atggagtctc 234120 gctctgtcac ccaggctgga gtgcagtggc cagatctcag cttactggaa gctccgcctc 234180 ccggtttcac gccattctcc tgcctcagcc tcccgaatag ctgggactac cggcgcccgc 234240 cacctcgccc ggctagtttt ttgtattttt tagtagagac ggggtttcac cttgttagcc 234300 aggatggtct cgatctcctg acctcgtgat ccgcccgtct cggcctccca aagtgctggg 234360 attacaggcg gtagtttttt aattaaaagg gaaagctgat tttatttggt gagacttctg 234420 ctatcatctt ccgtgttata tcccaatatg agtatttttt taaatgttct actaaatcca 234480 atagtacatt cacctcactc ttgagttaaa ctcttgactt taaaaaaatt agccagaaaa 234540 aaaaatcata agaaaaaatg cagcatttta aattctataa atgagctatg tcttaaacta 234600 tttgggagca taactcaatt gtattcattt tagtttaaga tcatgcaaaa agggaaaggt 234660 atagatgcta ttttattgat atgctgctcc acagatttca aattcaacat cataagccaa 234720 gatttgtggg accagaggaa tgttcaaaag tataatctga taaattatct gttgcagaaa 234780 ttaagtaaaa tattgcatac atctcacttc ctataccaaa tagatagaat gaaagtacta 234840 gattttgtat cacagatagt ttagacaact acagggaatt ctgaactttc aaacttttat 234900 atcctaaact caagatttgg gccttgaaat ataaaactga caaaactgct acagtgtgga 234960 tttttaaaat tacagttttc ctgtggtaga gttgacactt tctgttggta tggctagaag 235020 tcagatagat gcttaatgtt aaagaccatg tttttatttc ttctcttttt ctcaccctat 235080 gatttcattg acctaaagtg gcttttagtg ctgttcaatt cacacagaag ccaaaattgg 235140 ttactgcgtt aagaagaaac caagaggttt tatttagttc atgaaacatt agcaaaactt 235200 ctgtttgatg caaaactgca aggaagtttt gtagtcattg aaaggagcaa gaatatacag 235260 attgcttgca gttccagtgt agagacattc attatcagat ttaccacttg aaaagattat 235320 caagatagta tttttattgt gtttaccagg taaactaaga actttagttc taagcacttt 235380 acctatttta aatcattaat agtgctgtaa caagcctctg aggtaggtac tgttatccct 235440 ctttaacaga taaagagaat gaggcacaag gaagagaagt gacttgctaa aagcacacac 235500 agctgaatgt ggaccctgat tcaaatctac acatcctgac tcaagcatcg ttgctctgta 235560 ttactgtgct acagtgcctc ttcacatcct cctgatgcag aaatcttctt ctagaataat 235620 gagaagcagt gtgagctttg aagtaggact tcctgagcat ggtgctttcc atcatctctg 235680 ggccaaagtt ttctcatctt tacaaaggga ttatgatcaa cccccatctc atactgtggt 235740 taggagaact gaaaaagacc attatactaa aagatgtcag aacagggcct gacagatcat 235800 agggcccaat aaacatgagc tcttgttatc atcataaata tgttaaaagc agccttagta 235860 tatggataat agtagcagaa tttcctgaat gagacatgtt aaacatttat taagtgggcg 235920 ctttttagag tttatcctat aataattcag taaggttact cttgtcatcc ccatttcact 235980 gaatttgagg aatctcaggc tacaagataa catattagtt ttctagaatc aaataagcaa 236040 ggattcaaac tcaggatgta ttgatcccaa aacctcagat atttctgccg tccctgtctt 236100 gttctaaacc ccaggtttgc tcatccaggc cctagttatt gatcaaaaag caccaataga 236160 aatcagagta gagaaagtca tattgagctt gtgagattgc attatgggcg tggtaacaaa 236220 tgtcattcag atgttttggc acagtgcata acaaccatac ttaacctctg tactaagacc 236280 tgtctgagcc cataaataaa gttacattaa taattatgga atgataaggg accactcaga 236340 aaatcttggt tgatatagga agtggcgtct gtggcttcta attaagagat attgcttctt 236400 gaatcagttc ctgaccattg ctctaggggg atattaagcc ttctctgtcc atgggagatg 236460 tgaaattcaa cagctgacct gactgcttgt cgctgttgat gatcctataa aatttcttct 236520 aagataagaa ctctgtgttc tagtccaaat caagtgaata tttcctgttt gttgacctac 236580 agcttcaagg gtatgaggtc ataagtttaa aaagatttct tttctctcca ttgttgtgag 236640 agtcattata gttctatcaa atgctccaag tgaatcctgc atatttcctt tttgccagat 236700 atgttagcta ttcactctat tttcctatct cctctatgct tttacttttt ccctcatctg 236760 tttaccaatg gtaccctgaa ttttagaacc agacaggtag taggacaagg caggtgaaac 236820 tacacaggtt gtaaatttca gaatgcaggt tcaaatttca tcgttgtctc ttgctaactg 236880 aatgaatata ggtaagatgt tttacctctc agagtcttac ataccccatc tgtaaaatgg 236940 gaataatact gtcttccatg gttttcttga gcattaaatg tctctattta tggaacacag 237000 tttcatgtag taactgattc tgtaccaatg ccctgcctcc tatgtaggca aatgcatgtc 237060 ccaaaagacc caaaacaagt tgtccctctt ttcaagatga agctttgtaa tctctcctta 237120 aatttatcca gttctggtgt ttaatttcct ttataagcca gaagttgtct tacgtctcac 237180 caaatcttat aacatgaata taatactgtc ttccaaatgt gagcctctaa ttaccttagg 237240 ccaatagcag agcctctgat cttatctttt ctccttttcc gcttaccaga cagcacattc 237300 tgctgagagt tgggacccaa aaagatataa atcaactagg gggcagaaat ggagattcct 237360 aagctcctcc cagagtttga ctcagtaggc ctgaggttca ggggcttgat gttaaacaag 237420 caagcccagt ggttctgctg caggtggatc agactcccaa gaccacattt tcctagcact 237480 ggcctttagg aagagcacgt gcctactcta tcagagtttg tgcagactat gattgcagcc 237540 tagtttatgc agactattga ttgcagcctc ttggcaaggc tctataagga aaagggagcc 237600 aacgtgtaag taaattatca cggccatgaa actcctcatc tgagagggtt tcctctcatc 237660 ccttcatccc tttgtgtctg ccccagaatg ccagactatc ttctccagat agacccaagt 237720 caatctctta tttttaagcc attcctcatt ctcctatata gtccaaaata gcaaatacat 237780 ttttaggaat tctcttgctt tatgggtgtt catccaaaaa tatttcatta taagaataag 237840 tgcttagctt atcctgtagt gtctttctgc tctgatattt gggcccttcc tttccacata 237900 gttgcatttt ctttgatggg cagatgctgc ttctttaata tttttcacaa ctctgtgctt 237960 ctaacagagc aattatttca ggaagagggc acttggagag ttgtaagagg ctaaggagcc 238020 catgtctctg ccttggattt gtgtacctaa atgttaccta attagataaa cctgaaaaag 238080 atttggaagc aaagtagaat gaaatggaaa gtgtttggat aataagaatt tggacattgt 238140 tgctctgtgg tgatgttggc agactctaag cttcttgcct cattttattc attcatgtat 238200 gaaggagtta tactcagtca taagtcacta aaatttgtat tctacatccc attagtaaag 238260 tatttttgaa cacacatgat acatatgttt acatatttgt aagttatata tatgtacaac 238320 gttctaatat attctgttca ttgtcaaact taaatatata taaatttggt ttaatataaa 238380 atataaaatt agcattagtg tctgtgtgtc tgtctcattt ctgaaaaaag cgcaatatgt 238440 actaagttaa aggttcattc ttaatagcag taggagtaga tctttatttc aaatagtctt 238500 tggggtaatt tcctgttttg gaagacagct tatcagattt ggttagagtt gatgaaagct 238560 tattctaggg ttaagaaaag tattagctca gccattttct tattgttgat ttgggcttgc 238620 ataattaggt ttaccttcag tatgaagttt ctttacatga atctgtttaa cccacttatt 238680 tgttatataa ttattagtta aatgaatgtt aaatcagtat aatctattta tccacaaaat 238740 cggtcataca gaacctgcaa aaaaaaaaaa aatgctctaa catgttacat gaagagataa 238800 ctaaagatac tacaaacaac ccctctgaac agtaacactc ccactcttcc tgcaaaattc 238860 ctctcatagc aaatgcaaca tgtgactcag acacaggctg actgaaggct ttatgtgact 238920 cttacatgcc caatattaga aaaccttaat ttctttccta ttttttataa acaacatata 238980 taaacaaaca ttttagtata ttctcattac ccaatggatg gtcttgcatg gtccattttg 239040 aagacagtaa actatagcct ctatttttat ttaatttcaa atacctgttt gccaatattc 239100 acagccagct tttgttaatg ttcttttctg tcctgtgaat cctgatgtca tatcttgcaa 239160 catccactct aaagcctatc tttgcactcc cgtccatccc ccattctcta ttattgtgct 239220 gcctctgatg gccagagaaa aaaatcttga aaatacatat tgtattgccc tacgggtaga 239280 ggaaacagca gttatacaat tcaaagttgc agcaattcac cacactgttt agcaccctac 239340 taggtgtaag gaggaagctt gattttaaaa atatatgcaa taatgccttc ttcaagaatg 239400 tttgggagca tgcaagagct taatgctcat ggacatttac tttattccag caaatttaga 239460 cccaatctgt gtgtagtttc attttgtttt ccatttcctg attaactgac tatatatcta 239520 gctacttatt tgctgccatc tagtgtaata aaatatgttg attatacatg gaattttgag 239580 cccattatgt agttgaatat cagtactcaa aatgattctt tttttctggt ttcttataag 239640 tttacaaaat gcctagtcag ggacctttct tatcactgta accctgaacg tggtcttaat 239700 attgtgtcat agtatctagg gctcaggatc atgagccttc cttcattttc tataaacgtg 239760 acaattggaa actgggtagg ggcttagcag ttggtggatg tgaagtaaat atataagagt 239820 aatcattaag agatcatctc agtttagtga ccatgatttt tacttcatgg aggcagcaaa 239880 acacagcatg gattcttacc aatagtgtga ccatgggcaa tttatttctc ttttggaggc 239940 atcattttct tcatatctaa aatgaagtgg taggtccagg tgactgttga ggtctcttcc 240000 agctctaaga gtctgtgtct acatataaat gattttctct gccaaagtaa tgtttttaga 240060 gtcctttata atgccagaaa tgaatacggc ttctctagtt tttctatgta gctatctatc 240120 ctttggtgtg gttagaagta aacagcgatc ctgactggaa agagagggag gaaaatgtgg 240180 actatgattt tattcctttt attcttgaga gttgtccaat gggatattgt cccctagtgg 240240 ataagtagat acttgccaat atgcacctga cctcttcact cataatggga atttagaagt 240300 ataatacctg ttataatcaa cttcctaatc tctatccctt tttttatcac tctgtttcct 240360 attgtaactt ctctatgtgg tactataagt ctacagtaac atataggtgt ttccctttcc 240420 ttatgaagtt ttatacagct actccattat atcctaaaat gttccttttt cttgctttta 240480 tagtggggtc tttattgttg gccaggctgg cctcaaactc cagagttcaa gtgatcctcc 240540 cacctaatag tagctgggtt ttcttctgag tagctggtcc taaaatgttt tattttcaga 240600 ttatttcagg tgtataagtc ttattttccc aaccaggctg aaaacttttc agaatcaaga 240660 actgtcttta gtttctcatt ttttatgagg gaatgtggca ttattgctta gggaattcat 240720 gtattttgat aataaagatg cttttctgtt tgttcatata aattagggta aaagaggaag 240780 tataaaccta tctcaaatca agtacaggac tctataatta ttactggcta tctaacagct 240840 catagaagcc aataagtctc tgaacctaat gccaaagaaa gcaaccttac cataaagaga 240900 aaatccaaat aaaactaaaa gaggcaatgg gcagtgctac ctatgggaag aaaactggct 240960 tcacatccca gctttgctac ttattatctt tgtgttttgg ctaaaaattg tctaactttc 241020 ctgaagttaa gtttccttct ctataaaatg agggttataa tactatatac agcacactac 241080 acaaaagagt tgtgaagatg gaatgagaaa gcaaatggca aaaacttagc acaaagtagg 241140 agctcaatca atcatggtta aaaagaactt ttatccattg ttatttttgc ttatatacag 241200 taaaaattat ccaagacaaa tgtagtcaga gcatctgcaa ttgagcttta taaagtgaaa 241260 gataattctc ataccatagt ggttctcatc aagggtgatt tttgtccccc aggggatatt 241320 tggcaatgtc tagagacatt ttatttgtca cactggaaaa gaggggagtg ctactggcat 241380 ctagtacata gagagtagga atgatgataa gcattctgta atgcacagga cagcattcca 241440 caacaacaaa tgatctgatc caaaatacca atagtgtgga agttgagaaa ccctaccgta 241500 aagcctaggg agtccattac ttctgaccta aatttgtttt atgtttaaga gtgcatgtgg 241560 atcaaaagta gcttccattt tggtaggtta tgaagggagt tgtctaatct ggtgctttag 241620 attctaattt ggggcatatt tttaggctaa ggcattgcaa tatataaggc tttctaagtt 241680 tcagacattt tcttggaggt cagcaaacga aggcttgggt atctattaac ccactagagt 241740 agtgtaataa tggtggtggt tctttattga agactctata ataatctgat ttatttttcg 241800 gcaactgtat aagacaggta ttttgctctc attttacaca agggaaagct ggagcttaga 241860 gaatttatgt aacattacta gcaagttgca cagctgggat tcaaactgaa atcctgctag 241920 cttcaaagac tgtgctgttt ctactgatgc atactacccc tacctaccaa ggctctgaga 241980 ttggaaagca ggatgggtgt gttttaaagg aaataaggta ggaaagtttt caaatattag 242040 aaattctgct caagaagatt aggtcaagtt tcctgctgag gggcccttga gtatccatga 242100 actcgatgaa aactatgagc ttctcaggaa ggtagaccaa agggaaagga ttactccatc 242160 ctcacgctgt cataaggaca tacacaagac tgggtaattt gtaaagaaaa agaggtttaa 242220 tggactcaca gttccacatg gctggtgagg cctcacaatc atggtagaag gtgaaggagg 242280 agcaaaggca tgtcttacat ggtggcagcg aagaaagcat gtgcaaggga actgcccttt 242340 ataaaaccat cagatctcat gagacttatt cactatcatg agaacagcac aagaaaaacc 242400 tgcccccatg attcaattac ctcccaccag ctccctccca caacacatgg ggattatggg 242460 aggtacaatt caagatgtga ctttgtatgg ggacacagcc aaaccatatc accatgatat 242520 acaatttgcc aattcagcaa cagattttaa gtcttatatt tttaagcatg atgcaatata 242580 ttttatgaat tcttcctatt tatatgtttt ccttttaaat aggttctact atcttaacta 242640 tcactttcaa atataatgca agctacatat gccattttaa attttttagt agttacattt 242700 aaaaagtaag agggtgaaat taattttaac aatataggtt atttatccca atatatccaa 242760 actattatca ttttgacatg tagtgaagct cataaaagca ttttattatt atgagatatt 242820 tcttacatta ttttttccta atacatcttc agaatctggg tacgcatttt aactttccag 242880 cacatctcaa ttgggatgca aaattttcag caattaaagc ataatgtagc cctatcaaaa 242940 ctattaacgt tgtgtttagg aaaaaaaaat atttttcact gcttttattt ttaaatttga 243000 gcttaaatta attaaaattg aataaattta aaattcagtt ctcagtcaca ctagccacat 243060 ttcaagtgct caatagctac aaaagactca tggctgccat attggacagc acagatctaa 243120 gctcttattg ctcagaatgt ggtccccaga gcagcatcaa cagcatctgt gaactgatca 243180 aaaccaccaa tatttcagtt cacacctact gaatctgcat tttgtttaaa tgttttttat 243240 atatatactt taagttctag ggtacatgtg cacaacgtgc aggttgttac atatatatgc 243300 atgtgccatg ttggtgtgct gcacccatta attcatcatt tacattaagt atatctccta 243360 atgctatccc tcctccctac cccctcccca caataggacc tggtgtgtga tgctcagaat 243420 ctgcattttt acaagatccc caggtgatgc ttgttcacat gaaagttttg tctctctaaa 243480 tcgcagatct ttccatcaga gcccagaaaa agcacaagaa tcaataactg tgaggaataa 243540 ggaaacttgc cacaggagaa tggtgctagg gttggtatta atgatgtgct ctggtaaaaa 243600 gtcataagtt tcccagaaag gcaacaatgg ctattctatt gtttgaactg acacaggtct 243660 attctagagc ttggacttgg ctctgctccc agaatctaca tcaaagaatc taacactaac 243720 ttccatgact accacaatta aggcagctgc ataccccacc actatatata tttgaaattg 243780 caactttaga actctgtaac acagccgtga gcatgtttct gctacacaca agtggatnnn 243840 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 243900 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 243960 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnncc tcactaatcc ttatttggtt 244020 tgtttttcac agaactcagt atttgatggg cctttcaata ttttccttta aggaattcat 244080 tgtactaata tgacatagaa gctcattgtt ctaataaatg gtccccaatg ttggctgcac 244140 attagaatca cccggggcat tttgaaaaat accaatgccc aggcatcacc tcaatctaat 244200 taaattaaac ctgtggaagg tattttgtta aagatcccca agtgattata atgtgcagcc 244260 agagttgaaa tccaccggtc caattagaag gaggccttag ctagcagtca ggtgcccaag 244320 taaatgcatc tcaagcttta atgcgcatac agatagcctg ggatttgtta aaatgcagat 244380 tctgatccag taggtatggg tggaaataaa cccacatttg tgtacagatg tttctcttgt 244440 ggtatgtggt tggtgatcat tctcagtatg cttccatttc cggcaaactg ggttgagttg 244500 atgaccctat tcttactcct ccatgaaacc tttatctcgc ccacagactc ccagttctca 244560 ttaatcacta ctttctgtga tattctgaaa cagttattgt ctttaattgt gttttttcat 244620 tagctacttc tctatctgct tatgtacata agttatttcc tctactggat tacaactctt 244680 caaggtagat ccacatatca tgtcattttt ataattctca ctatacctaa agagtgcctt 244740 acacaaatgc cacttgttga ttaattgaaa cagggaatag ctgatgtgat atctcaaaaa 244800 atatccaaag gacttaaaaa tgcaagatgt ttttctttgt tggaccaaaa aggaaagttt 244860 agacaggcaa gggggtagga gatattgagg ctttcaattt ttatgttagc ttatttcact 244920 ctgggtacat atttaaattt tgaaaaatta ttttgtaatt taatgatttt aattatttgt 244980 ttgaaatagg gcactattga cattttggac tagatcattc tttattgtgg ctgtcatcct 245040 gtgcattgta atatgtttca caacatccct ggcctcaacc cactagatgc cagtatctcc 245100 ctttccccct gtcttgagaa ccaaaaaatg tctctagtca ttgccagatg tctcctggga 245160 aactcattca tggttgagaa cccttagttt agaaaaatgg aagtgtgaca cagctgtctt 245220 actgcactaa tatatgcctg aaaaaaataa aaattaaaaa catacacgta agagagtgac 245280 aagttatgtt ctgagcaata tgtgtatata taaatattaa tataaaaatg ttctctgttc 245340 ttgcattttg gaggccatgt gcttgtagat catatttatc tttgtattta tcatcttgat 245400 cattctcttt ataaaaatag aggtatattg catgcctctc agcttatgag gttacatccc 245460 aatcagcctg ttgtaaattt aaaaaatcat aagttagaaa tatcaaactt gaaaatgcat 245520 ttgataccct gataaatgca tcataaagtt gaaaaatcct aagtcaaacc atcatgagcc 245580 aggaattatt tgtatatgaa acatttttaa aatctgaaca tagacttggg aattttaata 245640 tgtagtggta gtaattccac caagcaagag aatgtacatg gagcaaaaat tattaagaaa 245700 cagtgactga gattattctc attctcagga aactggccca gccccttttc ataaaatatt 245760 ctgttcagtg tgctgtgatc cttggactga atatactgtt tcagtaagca tattgttcag 245820 taagcatatt gttcagtaag catatttagc ttaagcagtt gttaagctaa agcctgcaca 245880 ccaacaggtg ttcaatgact gtttgttgaa taaatgaaga atgaatgaat attaactgca 245940 tctctaaacc ctaaaattaa aaagctttag tgtgctcttc acaaaagacc ctattttgtt 246000 gcgtttgaaa cttcaagctt cagaaatgaa attacatgca agagtatatt atcatcaatg 246060 agaataaatg gcctcaacaa aattacaaga tagaaaacaa agtttcattg gtcagttggt 246120 ttcttctgac aatagaaggc tccccttaga cttcattagc ttcagatatt tcaatgacag 246180 aaacataatg ttggcaaagc attgctatac tttcaggctt ggattggaat gccccacatt 246240 tactttttcc taccattcct ggctaaaaac ttgacatatg agaaccagac acaaggctct 246300 agtggtagca agcagaatgt cttctaagct ccaaaggaaa aaaatgatat aagtcagtgg 246360 ttcccaaatt aaccatcaaa tgctaaccat taaaatcact ggggaacttt taaaaatcaa 246420 atggccaact aacaacaaac tgtctgaaaa agaaatttag aaaaccatcc catttttaaa 246480 agcatcaaaa aaataaaata cttaggagta aatttaacca aggaagggaa atatctgttt 246540 actgaaaact atgaaatgtt ggtgaaagaa attgaagatg ataaaaataa atgaaaagat 246600 aaatgtttgt ggattagaag aattaatatt gttaagagat ctatgctatc caaagcaatc 246660 tatagattaa atgcaatcct atcaaaattc caatgtcatt ctttatagaa gtagaataaa 246720 atcataaaat tcacgtggaa ccacaaaaga ccctgaatag ctaaagaaat cttgaccaaa 246780 aagaacaatg ctggaagtat tgcattatca gatttcaaaa tatattacaa agctacagta 246840 ttcaaaatag catgctactt gcataaaaac agacctaaca actactgaaa cagaatagtg 246900 agcccagaaa taaacccaca catctatgat caattgattt tcaacaaagg taccaagaac 246960 acacaaaggg gaaagacagt gtcttcaata aatggtgctg agaaaactgg atatccacat 247020 gctgaagaat gaaattagac ccttatctca tcctttatac aagaaccaac tcaaaatgga 247080 ttaaagactt aaacataagc cctgaaacta taaaattact gaagaaaata caggggaaaa 247140 gctccatgat attagactgg gcagaagttt catggatatg acctcaaaag cacaggcaac 247200 caaagaaaaa aatagacaaa tgacattgca tcagactaaa aaacttctgg gcagcagatg 247260 aaacaactaa tagagtgaag agacaaccta cagattagga gaaaatattt gcaaatcaca 247320 tattaggtaa ggagttaata ttccaaaagg tacaaggaaa tcaaactact caataacaag 247380 aaagccaata accctattaa aatataagca acaaacttaa atagacattt ctcaaaagaa 247440 gtaagtatca ccctgattta aaacctggca aagacacaat gaaaaaacaa actacaggcc 247500 aacatctctg atgaacatag acacaaaaat ccttgacaaa atactaacaa actgaataca 247560 gcagcacatc aaaaagttaa tttgccatga tagactagtg tgttaggttg ttctagcatg 247620 ctattaaaaa aaaaataccc aagactgggc aatttgtaaa aaaaaaaaaa aaaaaaaagg 247680 tttaatttgt tcatggttct gcaggctgta caagcatggt gccagcacct ggctagcttc 247740 tggagaggcc tcatggaatt tttattcatg gtagaaggtg aagcaggaac aggaacatca 247800 cacaggggaa gcaggagtaa gagagagtgt gagggaggtg ccacacactt aaacaatcag 247860 atcttacaag tacgcactca ctattgcaag gacagcacca agccataagg gatccacccc 247920 catgattcaa acacctccca ccaaggccca cctccaacat tgggcattat atgtcaacat 247980 gagatttgaa caggtacaag tatccaaact atatcaagta ggcttcattc ctgggatgca 248040 aggttgcttc aacatacaca aatcaataaa tctgattcac cacataaaca gaattaaaaa 248100 caaaaaccac atgatttcaa taggtgtggg aaaagctttt gataaaatcc aacatccctt 248160 cacatttaaa aaaaaaaaaa aaaaaaaccc ttaagaaact aggcattgaa ggaatatacc 248220 tcaaaatagt aagagccatc tgggacaaac ccacaacaac ataataataa atgggcaaaa 248280 actggaagca ttccccttga ggacaagaaa aggatgccct ttctcaccta tcatattcat 248340 gacagtactt gaagtgctag ccagagcaat caggtaaaag aaagaaataa aagacatcaa 248400 aataagaaaa gaagaaatca aactacctct cttcactgac tatataattc tatacctaga 248460 aaaacctaaa gcctgcacca aaaagctctt ggaactgata aacaacttca gtaaagtttc 248520 tggatacaaa atcagtgtgc aaaaatcagt cgcatttcta tacaccagta atgttcacat 248580 tgagagccaa accaagaatg caatcccatt tacaatagcc acaaaagaaa taaaatacaa 248640 ctagggatgc atctaaccaa gaagatgaaa gatctcataa ttctgcacat gatcttcaac 248700 aaagatgaca aaattagcaa tggggaaagg actctctagt cagtaaatgg tactgtgata 248760 aatgtaaatg tcagtaaatg gctagtcagt aagtgatact gactagccat atgtagaaga 248820 atgaaactgg acccctacct ttcaccatat acaaaaatta actcaggatg gattaattat 248880 tcaaatgtaa tatctcaaac tataagaatg taatattcaa atatatctca aactatatac 248940 aaactataag atattctatc tcaaactata tacaaactgt aagaatgtaa tattcaaatg 249000 taatatctca aactataaga atgtaatatt caaatgtaat atctcaaact ataagaatcc 249060 tataagaaaa cctaggaaac accattttgg acatcagcct tggaaaagaa tttatgattg 249120 agtcctcaaa agcaattcca acaaaaacaa aaactgacaa gtttttctgt taagaagcct 249180 tagtttaaga aaaagaaact aacaacagag taaacagcct acagaatggt gaaaatattc 249240 acaaactgtg cctccaacca agatctaata tctggcatct attaggaact ttaacaattg 249300 agcaaacaaa aaacaacccc atttaaaaat aggcaaacag catgaacaga cagttctcag 249360 aagaagacat ataagcagct aacaaacatg aaaaagtgtt tcacatcact aatcatcaga 249420 gaaatgcaaa tcaaaaccac aataatatgc tatctcacac cagtcagaat agctattatc 249480 aaaaatcaaa agaacaaagc tggaggcatc atgctatctg acttcaaact atactacaag 249540 gctacagtaa ccaaaacagc atggtactga taccaaaaca gagatataga ccaatggatc 249600 agaacagagc cctcagaaat aataccacac atctacagcc atctgatctt tgacaaacat 249660 gacaaaaaca agaaatgggg aaaccattcc ctattcaata aatggtgctg ggaaaattgg 249720 ctagccataa gtagaaagct gaaactggat cctttcctta ctccttatat gaaaattaat 249780 tcaagatggg ttagagactt aaatgttaga cctaaaacca taaacaccct agaagaaaac 249840 tattacctga atggtaatac cattcaggac ataggcatgg gcaaggactt catgtctaaa 249900 acaccaaaag caacagcaac aaaagccaaa attgacaaat gggatctgat taaactaaag 249960 agcttctgca cagcaaaaga aactaccatc agagtgaaca ggcaacctac agaaagggag 250020 aaaatttttg taatctactc atctgacaaa gggctaatat ccagaatcta caaagaactt 250080 caacaaattt acaagaaaaa atcaagcaac cccaccaaaa agtgggcgaa ggatatgaac 250140 agatacttct caaaagaaaa catttataca gccaacagac acatgaaaaa atgctcatca 250200 tcactggcca tcagagaaat gcaaatcaaa accacaatga gatatcatct cacatcagtt 250260 agaatggcga tcattaaaaa gacaggaaac aacaggtgct ggagaggata tggggaaata 250320 ggaacgcttt cacgctattg gtgggactgt aaactacttc aaccattgtg gaagacagtg 250380 tggcgatttc tcaaggatct agaactagaa ataccatttg acccagccat cccattactg 250440 gttatatacc caaaggatta taagtcatgc tgctataaag acacatgcac atgtatgttt 250500 attgcagcac tgttcacaat agcaaagact tggaatcaac ccaaatgtcc atcaatgaca 250560 gactggatta agaaaatgtg gcacatatac accatggaat actatgcagc cataaaaaag 250620 gatgagttca tgtcctttgt agggacatgg atgcagctgg aaaccatcct tctcagcaaa 250680 ctattgcaag aacagaaaac caaacactgc atattctcac tcataggtgg gaactgaaca 250740 atgagatcac ttggactcgg gaaggggaac atcacacact ggggcctctt gtggggagcg 250800 gggagagggg agggatagca ttaggagata tacctaatgt aaatgacgag ttaatgggtg 250860 cagcacacca acatgacaca tgtatacaaa tgtaacaaac ctgcacgttg tgcacatgta 250920 ccctagaact taaagtataa taataataat aataataata ataaataata ataaaaaagt 250980 caaaaacaac agatgctggc aaggctgcag aataaaaatt gaactctcat acagggttgc 251040 tgggaatgta aattagttca gccactgtga aaagcagttt ggagatttct caaagaactt 251100 gaaacagagt taccattcaa cccagcaatc ccactgggta tatatccaaa agaaagtaca 251160 ttgtttcttt tgaatattgt tctacccaaa agacacatac actcacatgt tcattacaac 251220 acttttcaca atagcaaaga catggaatca acctaggtgc ccaaaggtgg gttggataaa 251280 aaaaatatgg tacatgtcca ccatgggata ctacacagca ataaaatgaa tgaaatcatg 251340 tcctttgcag caacatggat gcagctggag gccattacac caagtgaggt aatataggaa 251400 gagaaaacca aatactgcat gttcttactt acaagtggga gctaaacatt gggtaaacat 251460 ggatataaag gtggcaacaa tagaaactgg ggagtaacag agtagcgagg tagggagcag 251520 aaggaggact aaaaaactgt tagatactat gctcattccc tgggtgatgg gatcagtcat 251580 accccaaacc tcagcatcat gtaatatacc ccggtaacaa acctgcacat gtattccctg 251640 aatctaaaat aaaagttgaa attacaattt ttaaaaggat ggaaactagt catcaatgtg 251700 tttttaattt tccaggtgac tctaacattc aataattatt ttaaatatta tttcggtctg 251760 tataccttct gccagctact aagtttcagg aattttgatg gtctcattaa agagaatctg 251820 acaaccccat ttacaagtgc ttcagctaag tttcatttag aatagtttca tattgccaag 251880 gatccagtag tgtctttttt acagtgagtt acaaattcct gtttttgtga cagtgacagg 251940 ccaaaattaa tgaactgtga tttttaaatt gaaaaagtga ctgtccaatg gagactaaaa 252000 agaaaactaa aattatattt ggtcaatttt agtgttaagc atgatttttt gctttgtatg 252060 ttttagatag actttttcat tgagataaaa cccaaatagc ataaaatcca cctttttaat 252120 ctcaaagtgg tttctggtat attcacaata ttgtgcagca atcactacta tctaactcta 252180 gaacattttc attacctcat catggaaccc tgtacctgtt agtagtcact cccagtttcc 252240 cattcacctc atttcctggc aaacactaac tacttttctg ttgctctgta tttgactatt 252300 cttaacattt tatgtaaatc aaatactata atatgtggcc ttttatgtct gatttctgtc 252360 acatagcaac atgttttcaa ggttcattcg tgttgtagca tgtatcagta ttttattcct 252420 ttttaagaca atactttatt ataggattat accacatctt gtttatccac tcatcagttg 252480 atggaccttt gggttgtttc tacttttctg ttactttaaa taatgctgtt atgagcattc 252540 ttgtacatgt ttttgtgtga tcatgcgtgt ttgcttctct gggcatatac ctaggagcag 252600 aattgcaggg tcatatggta actctgtatt taactttttg agaaaccccc aaattgcttt 252660 ccccagtagc tataccattt tacattctga acagaagtgt gtgagggttt ctattacttc 252720 atatcctctt gctttctatt ttaattattt aattatttaa tttaattatc taagatgccc 252780 tttaccctaa ccaaccagaa aataaacttg actgaattta gtgctaattg tttttgcata 252840 gttattcagt ataattgtcc ttgacatctc aaaacactgc ttatgcagaa tacacttttt 252900 taaaatagtg aaatcatagc aattctattt cgtaagtcag ttcttcttca gggtagtaag 252960 ttataggtct ttgaggtcat gttcctgttt ccatcttcca aaaggctaca ttattagaat 253020 cttgttgctg tatctacctt ggcatatccc cctctctatc cagagaaaag atcactgagg 253080 gaatactgtc cccacgtttc tatcttagag gcctcattag gagtcactat gcttttaaga 253140 gatggataaa gagctagaaa tcaagaggaa gagagaaaat tttaaataag acagaggagt 253200 atatgatcac tctttctaag aagattaaat gaaataattt gaaaggcaat aaactaactg 253260 caccaagtaa atcttgtgaa agcgaaagga aagaggagaa ggaagatgat tgattgagtg 253320 ttgtctacgg ccataccacc ctgaatgcac ctgatctcat ctgatctcgg aagcaggatc 253380 gggcctggtt agtacttgga tgggagatga ttgattgagt gctgaaaact aggataaatt 253440 gtattcagcc accagcatta agggaagtac atacaataca ttttatgaag aaagtgttcc 253500 atgaaaataa aataacaaaa agtaagtttg gtgaagattt aaatgataaa tgccaatagt 253560 agtatatgtg caatcatctc ctgacactgc tatacaaatg agctatctat ataggctgtg 253620 accacttaac ttcacctgcc aaaccacagt gctataaata aatacttttc caagacacta 253680 cagagttcag ttgacttgaa attcatctta cagtaactgg aaatgtagac tgtgccttta 253740 tttgggtcaa tcctacagtt tttttaatgt accaggaatt cattatttaa agtttactag 253800 ggtttaattt aaaattataa aaaaggaaga agttggctag gcatggtgac tcacgcctgt 253860 aatcccagca ctttgggaag ccaaggcggg caaatcacga ggtcaggaga tcaagacaat 253920 cctggccaaa atggtgaaac ccagtctcta ctaaaataca aaaatttgct gggcgtggtg 253980 gcacgctccg gtagtcccag ctactcaaga ggctgaggca ggagaatgac ttgaacccgg 254040 gaggcggagg tggcagtgag ctgagatcgc accactgcac tccagcctgg tgacagagtg 254100 agattccatc ttaaaaaaaa aaaaaggtgg ggaggctgag gcaggaaaat ggcgtaaacc 254160 cgggaggcgg agcttgcagt gagccgagat ccggccactg cactccagcc tggatgacag 254220 agcgagactc cgtctcaaaa aaaaaaaaaa aagaaagaaa ttaatagttc aggtgagaac 254280 tggtgaattt ttattctcaa ctctaagcta gtaagtgctt aaatagaaga cttcacaaca 254340 agctgtacct tcctcaattc tacagagaat catgaggaaa atcaggtata aatgtgaatt 254400 tcttatgttc agtactgtcc aaaagaaaat attttattaa attttttgtt ggttgccatc 254460 attatttaaa gccttcctgc cagtagccta tactattttt ggaatggagt gtttgtagtt 254520 tcataaccac ttggtaacac cataggttaa aaaaaaaaaa aaaaaaaaaa aaaaaaaagg 254580 ctaccagtct ttttcaaatg gcctctttaa cactgcttta tagggaagtt cagttacttt 254640 tgacaataat gacaagccaa aaaaatttac acatctattt taccatattt tgatacacta 254700 gcagcatcca ctcaggacag tacctttatt aaaagggggg ttaaggtatt tttaaatgga 254760 ggaattcctg aattcctgaa gctcttcaaa caaagtagca cttgggatac gacaagagta 254820 ctttggagaa ggctgcttgg tcccaaaaca gagattcaag aagagaactc cagctagctg 254880 ggtaaggtat tccctcctct aagtgtttat gtaggcctgc tgggggccag gaactgtgta 254940 aaactcagta aactcagtac ttctcagcac agaatccagt cccaaggaag cacccagcaa 255000 aaatttagat tgaatttcct ttaaaataaa atgaagaaaa aagttaaatt taaaaaaaaa 255060 aaaaatacaa ttcaactact cagcccattc tcttcagggt agctttggct cagaatggtg 255120 gaagagttgg acaggctatt agggaactca aaactcccca aacttcagtt cagcactctt 255180 cctttataat atattttttc tgaaaagagt attgccaata tatcaataaa gctttttgct 255240 atgacttcag agtgtccagg tcactaggga aaagtatcaa gtagcatcct gaatccacaa 255300 atcctttgag agccagccac acagtatctg cgtgagtctg gtaattctct ccccttatga 255360 gtgtcgtcac agaattgcag cactctcctt ttattgtttc tcaggaaaac atagacaaag 255420 cctctgcttg gatttttttt tttaatttta acactaatat gtaataatac agcaacatct 255480 cctagttacc tagaactcag gcttcgacag ctgtgactgt ctagaataca accacagaaa 255540 atcacctctg aacagtaagg gaaatagctg ccacagtatc accacctact ccaagcttgt 255600 tcaacccaca accaacaggc tacaagtagt tcagtacagc tttgaatgca gcccaagaca 255660 aactcgtaaa ccttcttaaa acattatgaa atttttttgc aatttgctca tcagctatcg 255720 ttagtatgtt ttttgtcttg ctcagacaat tctcttcttc cagtgtggcc caggaaagcc 255780 aaaagattgg acacctatac tttggatgtt tcatctagta ccaatatact tataattacg 255840 tgtttcaact agtactaatg aactttagtt acaggatgaa attccaaatt agcaatgttc 255900 atcatttgct cttcctaggt aacaacagtt aacaaatcat aggttgacaa tcacaactga 255960 ttttgaggat ggaaataata acagtgagca tttatataat gcttactcta taccaggcac 256020 ttttctaaga attttacata gattagctca cttaatcttt acaataaccc tgtgacatac 256080 cattattatc cccattttac aggtgaggaa actgaagaag ttaagtaatt tgcccaagat 256140 tacagattgt atgtaacaga ggtaggattt gaactcagga gtctggcacc aaaatcagca 256200 ctctcagctt ctacccagta ttatcaaaag taatttcctg gtaacttcta tcaattgtca 256260 tggcgactct cgagataaag aattattgtt tttaataaat aatgtcattc ccagaaatga 256320 attatgtgtg aatcatacta agctgccgtg agagactgaa tatcaccatc agagtggtga 256380 atctacttag tgtaggggta aaagaccaat ctctcccagc agccctacac atagttacac 256440 cataattcag tagggtaatc cctgatcccc atgcagtcat aaaaaaggtt aaatgatgtt 256500 taacagattt cgctaatgat tcagagaatc ttaaaataca tcttaggaaa actaatttca 256560 ggagcaactt tcagttagct agaaaataca gttctgttga gcatctcgta atctatgcca 256620 gacaaaggag acattcttgc ctttctttga gggaattata gaccaacaat cttattaatt 256680 ttcaactttc atcgaggcaa gattagcttc atgcacaatg tttctcaaac tgaaagtagt 256740 gacctatatt aataaatcaa tttatagtgt tgcaagcagc atcatttata atttgaagtt 256800 agaattaatt gcaggcagta attttgagat attttatttt acatgtatgt gtgtgtatct 256860 atcatataag taaatatgtg agaacatttt aaaatattta aaaatgttta catatttaaa 256920 gtttaaacat gtaaatatat ttatattaat aatataatta atataaatta atatgttaat 256980 ttatatgtta ttaatttata ttaacaatat ataaacaata tattcattag taatatatta 257040 cgtatattat gtaattgtat tatatattac tatattaaat atattaaaat aatacattta 257100 atatattaat aacatactaa ctatatatta ttcatatttt taatatatca ttttaatata 257160 tttaaattta tacttaaaat ttacatatat aaaaataatt ttcctgaaag tgactttcaa 257220 aaactttgaa agccaccagt gcaatggtta agaatacaaa ttctgggctg gccatggtgg 257280 ctcacacctg taatcccagc actttgggag gcctagatgg gtggatcccg aggtcaagag 257340 attgagacca tcctggccaa catggtgaaa caccgtctct gctaaaaata gaaaaattag 257400 ctgggcatgg tggcacacac ctgttgtccc agctactcgg gaggctgagg caggagaagc 257460 acttgaaccc aggaagcgaa ggttgtagtg agccgagatc acggcactgc actacagcct 257520 agcgacagag tgagactcca tctcaaaaaa aaaaaaagaa tgcaaattct gaagtgcagc 257580 tgttgagtag gatcatggct gtgccactta ataaccaagt gactttgggc cagttatttt 257640 acttttctgt gcctcagtgt catctatttg gtagtgagaa taatagtacc tacctcattc 257700 tagttttgag aataaacacg ttttatatta catataaaat gtgtaggaca gagacctcaa 257760 agaagacgta gttgctgtca tattgttgtt ctgttcctgc ttaagaaggg gacttggaaa 257820 agtaatgatg ttgaatacag taacttcttt catcatggaa gaattgcata ttcacatctt 257880 ctttgctcat caaacctttg aagatcatgc atgtctcatt ctgtaacatt gccttaacca 257940 aatataaagg ctaaatacaa aggtgttttt aaataactga tacatttagg ccagtcaccc 258000 aaagatttta cccaaagcct atgcaggcat agtccaagaa gtagactagc tctgctgcaa 258060 tcaccatctc ttgtttatta tttgtgaaag gaacattaca gtttcaccac agttggcctg 258120 gcaacgtgct tattcagtcc tcagaacata tgaaagtgat ttcggctgac aataagtatt 258180 tcctcacttt ggcttatgtt cagtaatagc cattctttat ccagatcagg gtgactgagc 258240 atgctgtaac cattcttctc ttctaaaact gacccttgtt tgattgcata tgcagattgc 258300 ttagcagaac ccacgtccac cataacgggc caaaagtcat ttgatccaat gtgcttttct 258360 ttttttctct ctctctcttc tttttttaat tccatgaaat tttattaaga taaattaatt 258420 ataaacatta cagaacacat ttttttgaga cagagtctca ctgtgtcacc caggctgtgg 258480 tgcagtgaca cgatctcagc tcactacaac ttccgactcc caggttcaaa cgattctcgt 258540 gcctcagcct ccctgagtag ctgggattac aggtatgccc caccagatct ggctaatttt 258600 tgtattttta gtagagacag agttttacca tgttggacag gctggcctcg aactcctgac 258660 ctcaggtaat cctcccgcct cagcctccca aagtgcagga attgcaagtg tgagccactg 258720 cacctagacc caaacatgat tttttgattg aatgcttaat gtcattgttt tgttattatt 258780 attattatta ttattattat tattattata ctttgttatg gggtacatgt gcacaacatg 258840 caggtttgtt acataggcat acatgtgcca tgttggtttg ctgcacccat aaaagttaat 258900 tcaagatgga ttaaagactt aaatgttaga cctaaaacca taaaaaccct agaagaaaac 258960 ctaggcaata ccattcagga cataggcatg agcaaagact tcatgactaa acaccaaaag 259020 caatggcaac aaaagcaaaa attgacaaat gggatctaat taaactaaag accttctgca 259080 cagcgaaaga aactaccatc agactgaaca ggcaacctac agaatgggag aaaatttttg 259140 caatccatcc gtctgacaaa gggctaatat ccagaatcta caaagaactt caacaaattt 259200 acaagaagaa aaccaaacaa ccccatcaaa aagtgggcaa aggatatgaa cagacacttc 259260 tccaaagaag acatttatgc agccaacaga cacatgaaaa aatcttcatc atcactggcc 259320 atcagagaaa tgcaaatcaa aaccacaatg ggataccttc tcacgccagt taaaagggtg 259380 atcattaaaa agtcaggaag caacagatgc tggagaggat gtggaaaact aggaacactt 259440 ttatactgtt ggtgggagtg taaattagtt caaccattgt ggaagacagt gtggcaattt 259500 ctcaaggatc tagaactgga aataccattt gacccagcaa tcccattact gggtatatac 259560 ccaaaggatg ataaatcatg ctgctataaa gatacatgca cacatatgtt tactgcagca 259620 ctattcacaa tagcaaagac ttggaaccaa cccaaatgtt catcaatgat agactggata 259680 aagaaaatgt ggcacataca caccatggaa tactacacag tcataaaaaa ggatgagttc 259740 acatcctttg caggtacatg gttggagctg gaaaccatca ttctgagcaa actgtcacaa 259800 ggacagaaaa ccaaacacca catattctca ctcaaaggtg ggaaatgaac aatgagaaca 259860 tttggacaca gggtggggaa catcacacac tggggcctta taatttcttt cttcatttag 259920 gattaaagtc atttttgaag atcatttgcc tattctttaa aaattgtttt atttagtatg 259980 tctttgcaca aggttaattc ggtgggtttt cttttcttga gatggagtct cactctgtca 260040 cccaggctgg agtgaagtgg tgtgatcata gcttatttta acctcgaact cctgggttca 260100 atcagttctg cctcagcctc ctgagtagct aggactatag gcacatacca ctacacccac 260160 taatttttta attttttgta gagatggggg tcttgctttg ttgcccaggc tggtctcaaa 260220 ctcatggcct caagtgatat gccttggcct cccaaagcac tgggttttct taatcatgtt 260280 aacaagtatt gttttgtttt gttttcttcc tttccttgtt gtttgtctgc tgccacccca 260340 acttgaaaag aaactgtcaa ctgctaatag ttagttacac tttggttaga gggcacggtt 260400 ttctcttcac accgccatac cattaaaaaa aaacagctaa gtcccctagc ctttgttcaa 260460 gaataatata aagtgtcagg gactgtggac agcacctggt ccatagcaca tggtgcagtg 260520 gagcagtgga ggtcctccat ttcaggacag atagctgctg actgcctttc actctcctac 260580 ctggagctct ctgaagaaga ctgtcctttt ccttcaaaga ctcctctccc tccaaatttc 260640 ccctcactcc aactttcccc tcactcttca gttgctcctc ttcctccttt cttagtccca 260700 aaccccaagc caactttggg aaattgcatg tgattgcatt tggttgttat ttctgctttg 260760 ttgtgagttg tgcgtaaaaa aggatctcca gcgagagaac agagaataaa gcaaattaat 260820 acttctgtat ataagagctg cttgaaatcc tacttttata tactgtctgg gaagataatt 260880 ttcctccaag ggggaagcta ctaggtggcg aatgaggaag ccaactttat cctgctcagc 260940 ccatctgaag agcaaaacag tcacagtcgc gttaaagtga tatgtggcag ccaacaatgc 261000 ctccaagctc ctctgacact gtcaaatgta ggtttagact taatatcaag tttcatctag 261060 ttttaaaaac tggaatttag taaaattatt ttcaagcttt ctaaaccaca atttcaggag 261120 cagtaccagt ttaacaactt ttttttccat aagttattgg ggtacaggtg gtatttggtt 261180 acatgagtca tttctttagt ggtgatttgt gagattttgg tgcacccatc acccgagcag 261240 tatacgctga accctgtttg tagtctttta tcccttgccc cctcccactc ttctccctaa 261300 gtcccccaag tccattgtat cttttttatg cctttgtgtc ctcatagctt agctcccaag 261360 tatcagtgag agcatacaat gtttgctttt ccattcctga gttacttcac ttggaataat 261420 agtctggtca ctgcaaatac cattaattca ttccatttta tgtctgagta gtattccatc 261480 atatatatat atagattata tatgtatata tgtgtgtata tatagatata tatgtatata 261540 tgtgtatata tagatatata tgtatatatg tatatttata gatatatatg tgtatatatg 261600 tatatatatc acagtttctt tatccactcg ttgattgatg ggcatttgaa ttggttccac 261660 aatttggcaa ttgtgaatgg tactgctata aacacgtacg tgcaagtatc ttttttgaat 261720 aatgacttct tttcttctgg gtagatcact agtgtgattg ctggatcaaa tggtagttct 261780 acttttagtt cttaaggaat ctccacactg ttttccacag tgactatact agtttacatt 261840 cccaccagca gtgcagaaac gttccctgat caccgcatgc atgccaacat ctattttttg 261900 atttttttca ttatggccat tcttgcagga gtaagatggt atcacattgt ggttttgatt 261960 ttcatttccc tgatcattag tgatgttgag cattttttca tgtgtttgtt acccatttgt 262020 gtatcttctt ttgagatttg tctattcatg tccttagcct actttttaat gagattgttt 262080 ttctcttact gatttgtttg agtttgttgt agattttgaa tattagtcct ttgtcagatg 262140 tatagattgt taagattttc tcccactctc tgggttgttt gtttactcta ttgactgttc 262200 cttttgctac ggaaagtgct ttagtttaat taggtcccag ctatttatca ttttttttta 262260 tctttttttt ttttttttgc attttctttt gggttcttgg ttatgaaatc ctcgcctaag 262320 cagacatctg gaagggtttt tccaatgtta tcttctagaa tttttataat ttcagttctt 262380 aggtttaagt tcttaattca tcttgagttg atttttgtat aaggtgagag atgaggatcc 262440 agtttcattc tcctacatgt gtctagccaa ttatcccaac accatttgtt gaaaagggtg 262500 tccttttgcc actttatgtt tttgtttgct ttgtcgaaga tcagttggct atatgtattt 262560 gggtttattt ctgagtttct ctattgtgtt ccattggtca tctctgtgcc tatttttata 262620 ccagtaccat gctattttgg tgactatggc tttatactgt agtttgaaat caggtagtgt 262680 gattcctcca gatttgttct ttttgcttag tcttgctttg actatgtggg ctcttttttc 262740 attccatatg aattttagaa ttgttttttt ctaattctat gaagaatgat gatagtattt 262800 tgatggggat tgattgaatt tttagattgc ttttggcagt atggtcattt tcacaatatt 262860 gattctaacc atccatgagc atgggatgtg tttccatttg cttgtatcat ctgtggtttc 262920 tttcagcagc attttatagc tttccttgaa gaggtctttc gactccttgg ttagggatat 262980 tcctaggttt tttgtttttt gttttttgtt ttttgttttt gtttttgttt ttgtttttgt 263040 tttttgcagc tactgtgaat ggagttgagt tcttgatttg attctccact tggtcactgt 263100 tggtgtatgg aatacctact gatttgtgta cattaatctt gtatccggaa actttgctga 263160 attcttttat cagttctagg agctttctgg aggagtcttt agggttttca aggtaaagga 263220 tcacatcgtc agcaaacagt gacagtttct tcctctttac cgatttgaat gccctttatt 263280 tcattctttt gtctgattgc tctggctagg acttccagta ctatgttgaa aaggagtggt 263340 ggaagtgggc atccttgtct tgttccagtt ctcagaagga atgctttcaa cttctccatt 263400 cagtattatg ttggctgtga gactgtcata gatggcttat attacattaa ggtatgttcc 263460 ttgtatgctg attttgctga gagttttaat cataaaggga tgctggagtt tgttgaatgc 263520 tctttcagca tctattgaga tgatcatgta atttttgttt ttaattctgc ttatgtgtgg 263580 tgtatcacat ttattgactt gcatatgtta aagcatccct gcatccctag tatgaaaccc 263640 actttattgt ggtagattat ccttttgata tgttgttgga tttggttact agtgttttgt 263700 taaggatttt atcatctgtg ttctttagga tatcggtctg tagttttcta ttttggttat 263760 gtccctccct agttttggta ttagggtgat gctggctttg tagaatgaat tagggagggc 263820 tcctttcttt atcttgtgga atagtgtcaa agggttggta ccaattcttc tttgaatgtc 263880 tagtagaatt ttgctgtaaa tccatctggt cctcgacttt tttgttagta attctttaat 263940 tactatttga atcttgctgc ttgttattcg tctcttcagg gtatctaatt cttcttgatt 264000 taagctagga ggtttgtatt ttcccaaaaa tttatccacc tcttttaggt tttctagttc 264060 atgtgtgtaa aggtgttcat agtagctttg aataatcttt tgtatttcag tagtgtcagt 264120 tgtaatatct tctgtttcat ttcttagtga ggttaaatgg attttctctc ttcttggtta 264180 atcttgctaa tggtctatca attttattca tctattcaaa gaaccagctt tttgtttcat 264240 ttatctcttg tatttgtttg tttctttgtt tcaatttcct ttagttctgc tctgatcttg 264300 gttatttctc ttcttctgct gggtttggat ttggtttctt cttgtgtctc tagttcttgg 264360 aggtatgacc ttagaatgtc agtttttgct cattcagtct tctgtagggg tttacggctc 264420 tgaactttcc tcttagcgct gcctttgctg tatcccagag gttttggtag gttgtgttgt 264480 tattgtcatt cagtctgaag aatttttttt gtttttttga gacggagtct cattctgtca 264540 ccaggctgga gtgcagtggc acgatcttgg ctcactgcaa cctccgcctc ctggattcaa 264600 gcaattttcc tgtctcagtc tcctgagtag ctgggactac aggtgcatgc taccacacca 264660 agctaatttt tgtattttta gtagagatgg ggtttcacca tgttggccag gatgtactcg 264720 atctcctgac cttgtgatct gcccacctcg gcctcccaaa gtgctgggat tacaagtgtg 264780 agccaccacg cccggcccag tctgaagaat ttttaaattt ccgtcttgat ttcctttatt 264840 gacccaatgc tcattcagga gcaagttatt taatttccat ttatttgcat ggtttaaaga 264900 ttccttttag agttgatttc cagttttatt ccacggtggt ctgagagagt gctcgatata 264960 atttcaattt tcttaaattt gttgagtctt gttttatgac ctatcacatg gtctatctta 265020 gggaaagctc catgcgctgt tgaatagaat gtgtattctg tggttgttgg atgaaatggc 265080 ctgtatatat ctgttaagtc catttgttcc aaagtatagt ttaaatccat tgatcctttg 265140 ttggctttct gtcttgatga cctgtccagt gcagacagtg gagtactgaa gtcccccact 265200 attattgtgt tgctgtctgt ctcatttttt aggtctaatt gtgttataaa tgtgggagct 265260 ccattgttag gtgatatgtt tacaattgtg atattttcct gttggacaag gccttttacc 265320 attatataat gtccctcttt gtctctttta aatgctggtg ctttaaagtt tgttttgtct 265380 gatataagaa taactatccc tgctcacttt tggtgtctat ttgcatgaaa cgcctttttc 265440 caccccttta agtttatgtg aggccttatg tgttaggtga gtctcctaag gcagcagatg 265500 gttggtgagt tcttatccat tctgctgttc tgtatctttt aaatggagca tttaggtcat 265560 ttgcagtcaa tgttgaaatg tgaggtacca ttgcattcat catgctctgt gctgcctgta 265620 tactttggtt tttttgtttt tggtttttaa cttgtatttt tgttttataa gtcctgtgtg 265680 atttgtgctt taaaaaagtt atcttttgat gtttccagga tatgtttcaa tatttagagc 265740 tccttttagc aatttttgta gtggtggctt ggtaacggcg aattctctca gcatttgttt 265800 gtctgaaaat gactgtatct ttccttccta tataatgctt agttttgcta gatacaaatt 265860 cttggctgat aattgttttg tttgaggagg ctaaagatag ggccccaatc ccttctagct 265920 tgtaattctt ctgctgggaa atctgctgtt aatctgatag gttttccctt ataggttacc 265980 tcgtgcttct gtctcacagc tcttaagatt cttatcttcg tcttaacttt tgataacctg 266040 atgacaatgt gcccaggcaa tgattgtgat gaatttccca ggtattcttt gtgcttctta 266100 tatttggatg tctaggtctg tagcaaggcc agggaagttt tccttaatta ttcccccaaa 266160 tatgttttcc aagcttttag aattctcttc ttcctcagga tcaccaattt atcttaggtt 266220 tggtcgttta atataatccg agacttcttg gaggctttgt tcaatttttc ttattctttg 266280 ttctttgtct ttgttgaatt gtattaattc gaagacgttg tcttcaagct ctgaatttct 266340 ttcttctatt tgttcaagtc tattgctgag actttccaga gcatttcgca tttctttaag 266400 tgtatccaaa gtttcttgaa gcttttactg ttttttcctt taagctatct atttccttga 266460 gtatttctcc cttcacttct tatactgttt tttggatttc cttgcattgg gctttggctt 266520 tctatggtgc ctccctgact agcttaataa ctaacctcct gggttctttt tcaggtaaat 266580 cagggatttc tttctggttt gaatccattg ctagtgtact aatgtgattt ttgggggatg 266640 ttaaagaact tgattttgtc atattaccag ggctggtttt ctgatttctt ctcatttgga 266700 taggctctgt caaagggaag gtctagggct gaaggctgtt gttcagattc ttttgtccca 266760 tagggtgttc ccttgatgta gtactctccc ccttttccta tggatatggc ttcctgtgag 266820 ccgaactgct gtgattgttg tctctcttct gggtctagcc acccagtgag tctccccagc 266880 tctgggctgg tactgggggt tgtctcacag agtcctgtga tgtgaaccat ctacaggtct 266940 ctcacctgtg gataccagca ccagttccaa taggggaggt ggtggagggt gaggtgcaat 267000 ggactccgtg aagtttctta gctttggtgg tttaatactc tattttgtgc tagttggcct 267060 tctgccaaga ggtggcagtt tccagagagc atcagctgta atagtatgga gaggaactgg 267120 tggtggacag ggctctagaa tgaccaagat tatatgccct ttgtcttcag ctaccagagt 267180 aggtagggaa agaccatcag gtggggacag ggctaggtgt ggttgagttc agactgtcct 267240 tgggcaggtc ttgctgaagc tactgtgggg aatggggatg ggattctcag gtgcctggag 267300 ctgtgtacct aggaggatta tggctgcctc tactgggtca tgaaggttgt caaggaagtg 267360 ggggaaagcc agcagtcaca gaccttaccc agctcccacg caaaccaaag gaccagtctc 267420 actcccaccg tgacccccat gctagccctg agtctttcca ggccatgggc gagatgggct 267480 tgaaaacttg ccccaggcta cctgcctccc aactgtgaaa gaaaacgact tggctcttcc 267540 cccagttgtg gaatctgcac accagatttg caccctcccc caagttctgg ccaggaggct 267600 tcttgcccct tcaaattgtt acaaagttca gcaagagagg cttcttcctg tgcaatttta 267660 ccccctgctc ctcttgccac cctccctatg gatccctgtg gtgccaggcc agaatgggct 267720 gctcgaggac ccagcaaact cccagggcct ttctgctgct tcctctaccc ctgtatttcg 267780 ctcagctctg taaattgact cagctctagg taaggttgga aacttctccc acaaacacac 267840 cttcagttcc tccagtgggg gtatatattc agcagaggag ggtctccgtt tcacaattcc 267900 acagttgagg cactcacagt atttggggtg tctcccgggt cctgcagggg cagtctgctt 267960 ccttcagagg gtctttgggt cctctcagga ttgcgggttt gttcttgtag tcaatatgaa 268020 gcttaaattc acatcacgag ctctgcagtc ttctctgtcc ggagttgcaa tctagtcctg 268080 cctcccaacc gccatgatga tccagcctac aacttcttaa ttaattaatt cttattgctg 268140 gttcatagtc tgtcagaagt ttaggtagta ttatcattta gatgtactac tttgcacaca 268200 tagttaaaat atcttagctc ttcaaacatt cgtcatgaaa catgattgca ctcttctgaa 268260 gtgacagtat tcatcatatc ctccccacat cctcctgaac taggctctcg ggagttcata 268320 gcaagtgttc actcttaata tatatgtctg ctagaactga tcagggaatc taacaatatg 268380 gaaagccacc ttctcagtct tacatctaac tttatttctc tacagtagtg gttctcaaca 268440 tggattatgc tttgcaagca cctggggaac tttaaaaaaa atctcaatac ccaggctgca 268500 tctcaggttg attcaaatct ctggaagcag accaaggcat tagtactttt taagtctcct 268560 cccttcgttc caatgtgcag ttccagttgg gaattgcttt tagcgcatgc caggttacta 268620 atttctgagt gttgattaag ggaacatccg agctcatcat ttctcttgtg ggaatttttt 268680 gagaagcaag agagattggg gaacaaaata gctactgttt tttgctagtg caaagagctt 268740 agcttaaaat cacacagacc tatgttttaa tcccatcttt gctactacag gaatgtaaag 268800 atgggaaact cacttatctc ccctgcagtt tcacccattt ctaaattgaa ataacatcca 268860 ccttctggag tcagtattaa atgagatcat atgtgcaaag tgttcaacat gatgtagtat 268920 gtaacatgat aggacatagt aataataact aaagatatca ctacaaatca aaatccttat 268980 tttcaaaatt aagtctccaa agaggaaatg aaaatgaatc ccaaatctgt tgcctagatt 269040 tttgagtgcc aagcagcatt aatgctaata tttcttcagc attatcacta agagaaatga 269100 gtgttccaac ttaactcatt gttcttagtg ataattcatt tagggacaaa attaggctct 269160 cctgttaatt gccacattcc tttcagaggt gctataaatg gatgttgaac tatactattt 269220 ttagatttaa tctttaaaaa tcataagaaa gcaataaata ttactagttc agaaatgatt 269280 ttctgttcct ggcttatcag agaagacctg agagtctatc atagtcattt gttgtcttca 269340 tagtgaaacg aaaaagtaag attctaatag gatttttaga cttagtgaga aaggtgttca 269400 ttttaagatt atggtagttc ctctcagatt tggaaagcct taagataaca ctaaggagtt 269460 ggactttagg aatgctgagt gtcttcagcc acaatggcac tatagtacta gatgggacag 269520 gatgtgatta aggagaaact aagcagccag ccacaatgta gttcttcttg cctccaaaag 269580 aggagttact cactttctca cactcactgt gatacattcc atttgctaag aaaagtggct 269640 tgtgtcattc ttgtgcacta cttttaagtt ctgatatatt agattcattt actctgtatt 269700 aatagcattc aaatatttag taaagttaat atacttctca cactttttcc aaattaaccc 269760 accagctgtg tcctgtgctt aacgctatct tacaacactg cagtcaaagt gtcagccagg 269820 gctgtggtct catctgaagg ctggataggg aaaaattggc tcccatgttc acttacatgg 269880 ttgttgccag gattcatttc ctcaagggtt ttgattctga gggcctctgc ttcttgctaa 269940 gtgttggcca gaggccatgc ttagttcttt gctgtgtggt tctcaccaaa cagcaactta 270000 cttcatcaaa ccagcaggag ggtgagtctg ctagttaaaa agaagtctca atcttttgta 270060 acctaatcat agaactgaca tgcgctccat gctaccatat tcttttgatt agaagcaagt 270120 tactcaaggg aaggaaacac ataaggctgt gaatgagaga agacaggaat tgctggaggc 270180 cactttaggg gctgtctgcc acagcactta acagcacatt cccctagcca taaaatttaa 270240 aaaagcagga aagagagaag gagggtgcag ggtaaaatac agaaaggagg aaggtgaaag 270300 ggaagaaagg aagggaaaga aagacattta aaaagacaag aacaaaacag ctctgctgca 270360 ctacatctat gtagtagtgt agtggagagt tccatgtgca gacacacact tcatcacatt 270420 agcaccacac ccataaattt cctatttctt atttacaatg agaagattat aaggactttc 270480 tatgcatctg gagttaaaag gaagcaataa atctaagaac actaagttta agtaagcaaa 270540 atgtgtttca aattagttat tttttctttt taagtttttt gtttgtttgt ttcagctgac 270600 aaagtttttt atttctttct gtttcaagtt ttcaagttga gtttataatt cttgctatta 270660 tgtaacaggt ctattataca ggcaatatag gaacctgatt ggcattcgta tttggtgttc 270720 tattgttgtt tcaactcaaa tgccaaaatt atgtttttgt tctgtacgtt attgttcata 270780 gttatatatg ccccttaatt gtaaaagtga agctgtaaaa ttgtaaacta ctttgtacct 270840 tatctatcca ggcattctac taaggaaatc aagacccaaa tggcttggga agatcaacat 270900 taaatagcgt cagagccaga ccgagagtat acatctctca attgctaatc tagtgcattt 270960 gcttttctta tttctgtgca aatgaacagt tagaatgtga aatagtctcc tcagatctgc 271020 cagcattaaa acagttgtgg tttaagtatt tagttttaat aattactaac tttgtagaag 271080 aacctaaaat agtgtttgtt ttcagtgctt cagctaatag taaaaaggag tattttcagt 271140 actttactgt atgagaggtg cttgcctaac aaaatacaca tctttttcac tgtactcatt 271200 tgtaacagat aatgtgggct ccgacacctc agtgttctga gaggggttgg taaacgctga 271260 ccacatagag agagctgccc atctgccctc agtaccaagg cacatcccat ccatgcccta 271320 aaactcttgt aaatttctcc attcgtacag gaaaatgagt atttcttaca acaatatgac 271380 cgtggaattt gattacaaaa acattcctgc tatccccaac atgtgctccc agggctaaag 271440 acataatctg caactcagga ttttctgaag attcacttgt ttatactatt gagggcaaca 271500 gttgttttta aacaaggatg cggttcccag tcctatactt tcttcttacc ctgcttattt 271560 ttcttttttt attattatac tttaagttct gaggtacatg tgcagaacgt gcacatgtta 271620 cataggtcta catgtgccat ggtggtttgc tgcacccatc aacccggcat ctacattagg 271680 tatttctcct aatgttatcc ctcccctagc cccacagccc ctcaacaggc cccagtgtgt 271740 aaagttcccc tccctgtgta gatgtgttct cattgttcaa ctcccactta taagtgagaa 271800 catgcagtgt ttggttgtct gttcttgtgt tcgtttgctg agaatgatgg tttgcagctt 271860 catccatgtc cctgcaaagg acgtgaacac atcctttttt atggctgcat agtattccat 271920 agtgtatatg tgccacattt tctttatcca gtgtatcatt gatgggcatc tgggttggtt 271980 ccaaatcttt gctattgtga acagtgccac aataaacata catgtgcacg tgtctttata 272040 ttagaatgat ttataatcct ttggatatat acccagtaat gggattgctg ggtcaaatgg 272100 tatttctagt tctagatcct tgaggaatcg ccacactgtc ttccacaatg gttgaactaa 272160 tttacactcc cacaaacagt gtaaaagcgt tcctatttct ccacatcctc tccagcatct 272220 gttgtttcct gactttttaa tgatcgccat tctaactgat gtgagatggt atctcactgt 272280 ggttttgatt tgcatttctc tgatgaccag tgatgatgag cattttttca tgtgtctgtt 272340 ggctgcataa atgtcttctt tggagaagtg tctgttcata tcctttgccc actttttgat 272400 ggggttggtt tttttttttt tttccttgta aatttgttga agttctttgt agattctgga 272460 tattagccct ttgtcagatg aatagattgc aataattttc tcccattctg taggttgcct 272520 gttcactctg atgatagttt cttttgctat gcagaatctc tttagtttaa ttagatccta 272580 tttgtcaatt ttggcttttg atgccattgc ttttggtgtt tgtcatgaag tctttgccca 272640 tgcctatgtc ctgaatggta ttgcctaggt tttcttctag ggtttttatg gttttaggtc 272700 taacatttaa gtctttaatc catcttgagt taatttttgt atatggtgta aggaagggat 272760 ccagtttcag ctttctgcat atggctagcc agttttccca acaccattta ttaaacaggg 272820 aatcctttcc ccattgcttg ttttgtcagg tttgtcagat ggtttgtcag gtttgtcaga 272880 tggttgtgga tgtgtgatgt tatttctgag gcccctgttc tgttccattg gtctatatat 272940 cttatttggt accagtacca tgttgtcttt gttactgtag ctttgtagta tagtttgaag 273000 tcagagacac aatagaaaaa gaaaatttta ggccaatatc tctgatgaac atcaatgcaa 273060 aaatcctcaa tacaatactg gcaaactgaa tccagcagca catcaaaaag tttatccacc 273120 ctgatcaagt cagcttcatc gctgggatgc agggctggtt caacatacac aaatcagtaa 273180 acgtagtcca tcacataaac cgaaccaatg atgaaaccac atgattatct cagtagatgc 273240 aggaaaggcc ttcaacaata ttcaacagcc tttcatgcta aaaactctca ataaactagg 273300 tattgatgaa acatatctca aaataataag agctattcat gacaaaccca cagccaaaat 273360 catactgaat gggcaaaaac tggaaacatt ccctttgaaa accagcagaa gacaaggatg 273420 ccctctctca ccactccttt tcaacatagt attcgaagct ttggccaggg caatcagacg 273480 agaaataaat aaagggtatt caattaggaa aagaggaact caaattgtcc ctgtttgcag 273540 atggcatgat tgtatattta gaaaacccca tcatgtcagc ccaaaatctc cttaagctga 273600 taagcaactt cagcaaagtc tcaggatatg atatcaatgt gcaaaaatca caagcattcc 273660 tatacgccag tgacagacaa acagagagcc aagtcacgag caaactccca ttcacaattg 273720 ctacaaagag aataaaatgc ctaggaatcc aacttacaaa ggatgtgaag gacctcttca 273780 aggagaacta caaaccactg ctcaaggaaa taagagagga cacaaacaca tggaaaaata 273840 tcctcatgga taggaagaat caatatcatg aaaatggcca tattgcccaa agtaatttat 273900 agactcaacg ctatccccat caaactagca ttgactttct tcacagaatt ggaaaagaac 273960 tactttagat ttcatatgga accaaaactg agcctgcata gccaagacaa tcctaagcaa 274020 aaagaacaaa gctggaggca tcacgctacc tgacccagct tatttttcta cataggatcc 274080 ccacatccct gcctttgtta gaatggaaac tagacaagga ccaactttta tcaacttgtt 274140 catttctcta ttcctagaac agagcctggt acaaaatttg tgtttaataa tgtttgttga 274200 atgaatctga atgatggatt tgtttagaag gtttgtaaca ttccatccct tatgagtttg 274260 ttgctagtgg aaaaaagagg catgtttttg gttcataaca tcaggtatgt aacctggaat 274320 ttggaatcat gagttttcat gcatttgctt catattattt atttttaagt gatctttcaa 274380 agtattgata aagatacttt aagattgaga gcctccctga tacccaggaa tgaaagtttt 274440 agattaagtt tacaatctga ttgaaggcta atcatataag gagaaaaaaa ataaggaaaa 274500 gaacagaaat ttggaaagaa atctccaaaa tggccatgaa catcagaaca ctgagaatcg 274560 atatataaac atgtgttttg cttcatacct gtctgttgta catctatagc agcagatttc 274620 atagatgcag aggaattttg gctaaaatcc taacacataa aaggcattct gcacttactt 274680 ctcaaattag aattaataca tgtgtatgta taagttgttt agaattggca tctatttaat 274740 gagtttactg gctgaatctt ttaaaagaat gcaaacatac gtgactttta tcaaaaatct 274800 atgaaaagaa aaatggccct gtagtgcatc ctgtggttcc cactctacat cccccacgtc 274860 cacctgatgt cagcacaacc atctgtggca tccattggcc actatgccag tcaggtgcac 274920 actcaggtgc ctgcctcggc aaagaccctc agctcatgtg caggtagagc ctagaagtgc 274980 atggaggtga acatctctga ggcacccttc aaccagtggg tactgggagt gatagataaa 275040 tgtcctagcc tctcatcttt ctacacaaca atgctggtgc atattctaca cagtagctca 275100 gtaacacacg catattagtt gttctccctt tccttcccac cctccccatt ccctcactgc 275160 tacatctgga agccagatga actgcctata tccaaattct aatctctagc tctcgtttct 275220 taaacaggtc ctacaaaatg cttgaaataa aaggcaaaat ggtttgtatc tggaatcaaa 275280 ggctgacaat ggcaagcaac aagctctaaa actgacacag gaaaaatgct tttctggaag 275340 acattggcat cacctcctag acacggaata tgctggcttc atcccagtag tttcttcaca 275400 cacttttaaa tacgtgtctc attaggatca catatgaccc acctgatttc atgccttgcc 275460 ttttcttttt attctgcaga ctcttctaag gagcctaaat tcaccaagtg tcgttcacct 275520 gagcgagaga ctttttcatg ccactggaca gatgcggttc atcatggttc aaagagccta 275580 ggacccatac agctgttcta taccagaagg tgctgccctc atgcctttcc aattttcctc 275640 tccatggata tacctactaa agtacactga atcacatata gtgtgggaat agaagtgatt 275700 tgttgtgatt tatgtaatct atgaatattc attcactcat ttactgaaaa aaatattaat 275760 taagcctatc ctatgtgctg agtactattt taggccctgg agatatagca gtgattacaa 275820 aagacaaaat ccctggtctc atggagattt ccttccaatg cagggagaca ggcaataaaa 275880 attgaataaa atgtcaacta gtaatatagg ttattaagaa aaataaagcc agaaagcagc 275940 atatcagcag tgtttgggag tttgtgtgtg tgcatgagaa tgtatgagag tgtgtcaaag 276000 tatgagtgag agtgtgtatg ggtacacgtg ggcatgtgcc tgtggatgag agtgtgtata 276060 agaggcttga gtgatattga aatgggtgat cctaggaggc ctctctattg tggtgtccta 276120 caccagagac ataagtgaaa tggaacaggt cacgtgaata tctgggggaa aggctatcca 276180 ggcagaggaa attgcaagta caaagtccct gaggcagtct tggcctattc aaggaatgaa 276240 aaaggccagc actgaaggca caagattgaa agtgaggaga gtgatatggg aagagatcag 276300 agagttactt agggactgac tatgccaaac ctcgtagaca agggcaaggc tttaaatttt 276360 actttatttg tggtggaaag ctataggtgt ttttgaaaag atgcatgttt taaaagatgt 276420 agcttggttt ctaaccagat aatacactcc ttctcttaaa tatattcagt aaaagactgt 276480 agtacttttt catttttacc agtgatcctc taaaataaca gaggcagggt gaaacaaaca 276540 cctctcaata taggtaccac ccaagttgtt tatttcttcc ccttcacctg gcattatttt 276600 tgtttttggt ttactcttac tctgtatatt tttacctttt atacatttta ggcttaaaca 276660 cttcattatc tcttcttttc cacccaaccc ccagagaatg cctaagccaa gatgcaggct 276720 tagtgaggac cctttatcct tggctcaagg tgttcgttag tcggaggatg atattgtcta 276780 tcccacggaa gagctgggaa agggaaggaa gatgcagcca acagttaagg gtatgaactc 276840 agggccaaca aacctgcact tcagtgtact tctgcacttt ctctcttttt tttttttgag 276900 acggagtctc gctctgtcgc ccgggctgga gtgcagtggc cggatctcag ctcactgcaa 276960 gctccgcctc ccgggtttac gccattctcc tgcctcagcc tcctgtgtag ctgggactac 277020 aggcgcccgc cacctcgccc ggctagtttt ttgtgttttt tagtagagac ggggtttcac 277080 cgtgttagcc aggatggtct tgatctcctg acctcgtgat ccgcccgtct cggcctccca 277140 aagtgctggg attacaggct tgagccacgg cgcccggcca aggaatactc gggaaattag 277200 ccagtttgtg tacaactcag cctcctcatt tgcagaaagg agataacgga cttgcctcgt 277260 ggcttcttgt gaggatcgta tgagataacc catgaaaaat acttggcaga gtacttgaca 277320 cataataagt actcagcaaa ttgtagctga tattcttatt atcggtagta tagtgataat 277380 ttaaaaataa ttatgatata gcaatccagt tcctggacta taaagatgac tataagtggt 277440 ataagaccat ttataccaat aaattgttat aattattggt ataagaccat tttaatgcag 277500 agctgctgct taatttgcag ataaaaaaat acttggagtt agcaaccaag tggaccttcc 277560 ccacctttca gtgtaagaga ggtctcttgg atgaagtgaa gtgaagatga aatgtttggg 277620 caccaattat actatatttt tccttaaggc tgacaccaca aagaggttgg ggcctgtaaa 277680 caaagttgat ttctataaac acattcggac atgaagttag tatgtttgat gacacttttg 277740 aaatgtgtgg aatcgttatg ttatttgtgc aggcacaatt agccaaactg taaagaaaat 277800 tagcagaata acctcttaag ctgggcccac tttatgaaaa taattttttg ctacctcagt 277860 atttaccaaa tttgaatata agcaaaaaga gaaatcgaaa ggaatgaagc cttgataaat 277920 atatgtccct tgccctcatc aatcagcgtc acataactgt ttccacaggc atcttatgca 277980 caccccagtc atttcagcat ccctggttca aatccagcat ctacactacc aaggatgctg 278040 ctgaaagtgt gactgggtag agggaaaatt tcagacatat tcagaaagat gtcttagatt 278100 ttaccctgat agtgtttgga atcccaggag agtaagtaca acttcatgat taagtgccaa 278160 cccaaactta caaaattaga tatttgtgtt ttttctataa aatataacta ttttgaatat 278220 cttagccaaa ctactatgag cccacagccc agtttatcga agaagggtaa aactgaggga 278280 ttaggagtat caggattgga ctggactgat tagtgtacag atatatttga cttctcattg 278340 cccacttcac aaagaagaca atacaaatgc actttctgac tcttgtcatt gtttcttaga 278400 actcagttgc caggcaactc ctgaaactat agaaacatgc ttcgcatccc tgacacataa 278460 ataaaactgt ggattttatc caaaaccaga gtcagtggga ggtgcagttg tttcagtttg 278520 ctggcctggc ctgtctaaag cacaatggaa tgtgaacatg tcaggctgtc aacacgacat 278580 ttcaggcaca gccctacagg cagttgtgtg ttttgcgtgg ctctgctcct tgccaggtag 278640 ctggcagaag aggcagcctc cacatgttaa agcagctgat tcaaaacagt ctctgccatc 278700 ctgtgatggc gatagtgcca aactcagcct ctgagcttgc aggggactcg ggatgaatgc 278760 acattacagg catggcaaaa ggaggctctg agaagcatgt tcgagctgct ctgctctcag 278820 ctccttgcat gtaaaagctg tatttttaaa ggaactgggc atgtgaacac tcagtcctta 278880 aagttgtatc cctcacctct tccataccca ttcaacccca cttcaaaaat taccctagtc 278940 ttaagagaaa ttttattttc tatacaaggt tgtgtggaaa atcagtaggg agaaagggca 279000 ttattacttt catttttctt aaacaaaagt attgaattta aagccaaaaa catgtgagct 279060 ttctgtcatg aaaacagctg cccttaaaaa cataaatgag gttttatttt tattattttt 279120 tccagttggt tgtctttaga tgaaaaacat ttcttctgct ctttattctt atttttaatg 279180 atagtctctt tctatggttc tcaccccttc catttcacaa gatagtctgg cagcaaacct 279240 aaagcactta acttttggga gtaagagcaa agggtagctt ccatgaattg atttgggtct 279300 tctgtagaga cattcaaccc agagaaggca agtgacacag tatctgtttt atgagctaat 279360 ttgggttctt gtctacattt aatagtttaa aatataagtt ataaatattt atttaaagcg 279420 aaattcaaca ttggttcatg aagaaagagg ttggaagcag tgttttgaac tagctgtttc 279480 tgatccatca tgcttaaaat aaatgctttg tttgtcctgt ggagttcatg gatttgggat 279540 aatctaaaca gggtttttta cacagtcctc atggggacca aggtactgac atgcactgtt 279600 gagaaattct gtgaatcatg aaagagttaa tattttagaa atccagacct gttgagcact 279660 atctacatct ttgggacgtc ttaatacttt gagttttcta actttcatac tatcacttat 279720 gctaagtaca tttgatatcc cttctattat gtgaaagctt cattttctgg gcaatcttct 279780 tacaactact ctttttaatg cactcttact tagtttgaaa gtaaatgtca aattaagcat 279840 actatagttc aatgaaggac ccacctattc ctaatttttt taagcatttt tcttctgact 279900 ctacatacac acatgcttac acacgcacaa acatacacac acacaccccc ttatcttttc 279960 ttctgccttt tgcccactta ctttttgcat cagagatgaa tctcattcaa gcacatgcca 280020 gttgtttttt gttgttgttg ttgtttttga gatggagtct tgctttgtcg cccaggctgg 280080 agtgcagtgg cacgatcttg actcactgcg acctttgcct cctgggttca agcaattctc 280140 ctgcctcagc ctacctactg aatagctggg attgcaggag catgccatca catccagcta 280200 atttttgtat ttttagtaca gacagggttt taccatgtta gccaggctgg tctcaaactg 280260 ctaacctcat gatccacctg cctcagcctc ccaaagtgct gggattacag gcatgaacca 280320 ccgtacccag ccagcatatg caacttttaa gagtctcaac caaagcagca attcactatc 280380 tcagcccctg gagtctctgc catttaaatc ccaatttcct tccaacagct gaggagcagc 280440 cgtctcaagt accccctgat actacacaag ttttctccta gtgccaagca gaccagcctg 280500 agaaacagct ataagaagga aataggcatc ttctcccagc tttgcatccc ttccttccag 280560 gtcctgcctt ccttacagcc tgcaatgtcc tcattgtcca ctgctgccca gcacccatcc 280620 cacagaggga tggtcccaaa cctccacagt ctggcctgtg agccacagga gcctctggct 280680 gcacaggcca ttcctacctc atcttccaca accacagatt acgtggtttt atgtcccttt 280740 gacttataaa ttatcttctc aattaatagg ctagtgaata acaggggata atgaactacc 280800 tcacccaagt agcaattcta atttaagaaa actttcctgt cattccattg ccttttgctt 280860 cccttaccac actcatgccc atacttcctt acctcaatcc ctctgacctc tcagtttcct 280920 cccttccttg ccatattgcc atctattaaa cttttaccca tccttcaaga atgctaaaaa 280980 tacacctcca ccttgaagcc ttccatgaag agccacagca atcattccct cttctgaact 281040 tttaaggacc ctagagagca ctactaatga gcacttaccc acattgcttt gtaataccat 281100 tttttactct ttccttctga ggcaggagga attccttaga catctatgaa tcccccatag 281160 tgtctgtcat tatgtttcag acataaccaa ttctcattaa atatcaatgt aatgaatata 281220 agaggcccaa aaaactactc agatgggaat ttgagtctta ttttagcctg aaattagggg 281280 accacaactt acttatcttt atatctacac agtgttggtg ctggatgtaa tgcatcactc 281340 tgcccggagc acacatcaac ttgtctcctc agtttctttc accataggct gggaaaacag 281400 ccaggtctaa actttcactg ttctctggga ctctctagtt tggggtgatt ctctgtactg 281460 ttttaatgaa catttttaaa atgtccctaa gtctcagaac cttcatctat aaaatgggca 281520 taataaagta cctaccatag gaatcaattt atgaccaggc atagcatata cattcaataa 281580 acggaaggtt ttaccatagg cagaaacacc aaatggcctc ttagcagtct tcagacactg 281640 atgatattgt ccaccaatgt gatatgtctt ggaaatggtg ttgctaaaac acctcttcac 281700 aaaatatttg tgttccaatt tattgaatca gactatcaag caccttactt ggacttcagc 281760 tacaacatga tttttggaac aattaatctt ttttaatcct ccattttagg aatattcaag 281820 gacagactca agaatggaaa gaatgccctg attatgtttc tgctggggaa aacagctgtt 281880 actttaattc atcatttacc tccgtctgga taccttattg tatcaagcta actagcaatg 281940 gtgatacagt ggatggaaag tgtttctctg ttgacgaaat aggtaaatca caggtttttg 282000 tttcatttga catagtttta cactaaataa atggggaagc ctgcaaggtc caagtataat 282060 caagtaggaa gacttagtaa cagtgttcta tagatacgtg gagatctgtt ttacaggaga 282120 tgggatcagc tggtgaacaa gaggaaaagg gcagggggaa cttaagttga ctttaacata 282180 aagtaacctg gcagtaaatg atgtgaagaa aagaatagga accttgtgga gtcttttcct 282240 ttaggatatc tttgaagctg tgttgtgttc ttatgttcta ttgcaaaggg taaacttaat 282300 atattcttag gatttcttac ttcctaatta tttgatagga tgcttatatt cagattcact 282360 gaaatacgtt ggcctttgac ctctaccatt gctataatca aagcctagat tttctttatc 282420 acaaagcata atcattctgg aattttacat ttacaaaaca gccacagtca ctttaaagac 282480 atgtttataa gatctcagaa caaatactgg agacagttag ctcagtgaac taagtgaaag 282540 atccaaagag aggatccttt gcccatcata tggacacaag gtggaaacaa aacaaataaa 282600 acaaacaact ataattagaa tattcatgtt tataccttaa tagtataaac agcaaaatag 282660 aaagaatcaa agaaggacat tgagtagctg aaattggtgc ctcaaaatct atccacaaaa 282720 gctaatttgt tgcttatagg aattcctcat tgcttctccc aaatgtgttg ttcttttatg 282780 tggttttcta ggcataagct gactggaaga gataggagta tgtggttaga agttacagat 282840 ggaaacaaat aaaatctaat aggctgactt taagggagaa gattaagaga cctgtatcaa 282900 gcagtaaaga taacccaatt gctttgcaaa gacaatttag tatgtgtcct taacatcagt 282960 ggtatagctg ttgagctgaa actaaatggg atagcagaat gggatagtag caagaatact 283020 gggttaaaac ccatgttcta actctgttct ctgccaatag catatgacca gtcctactca 283080 tttacctggc tgactttcac tgaacacctg tcatgtgcca ggcactgttc tggtggtggt 283140 ggtggttata gaataagtac gatacagtcg aagaagggag tcaggcatgt tcacagataa 283200 ttgcagtgca gtgtgagagg ttttagcctg gaaatatgtg gaatgcacag ctgcaaaggt 283260 ggccaaatgt gtgaatgatt gacaggcctg agggatgagg aagggctgca cagagatggt 283320 gacagtttag ttacctctga actggaattg gactctccct attttttaaa aagtggctac 283380 ccacagtggt caaaagcatg agtgagtgtt gccaggtact gcagtggact tgcctttcag 283440 taactactaa gttccagcag taacaaatag cacatgttca gggactcagg agcagttaga 283500 aagccctcct agtcagctgg agaaatcatc agtagttgtt cgtgccccaa aaaggaattt 283560 ggagtttaac tgtcacaagg tacctttgag gatgtttaaa tagggaaatg acttgagaat 283620 agtaacagct aacagtcaca aaagacttac cacgtgtcag gtataaaaac catcttttgc 283680 aatcgcactt tacagataat gaaaccgagg cgcagggcat ttaaaggact agttcaagta 283740 aaacagctag taggtagagc tgggatttga acctccagcc tccatgcttt tactcttgag 283800 gctttgcagt accacttgtc tcattatcaa tgcctcagag aaattaatct tattgcaatg 283860 tgaaacatag attggagtgg gacagactaa aggtagaaga ggttagaaga ctgagatcat 283920 caaggtaaaa gattatgaca ggcagctaca actagcacaa tagttgtggg agaaggtgct 283980 gagagtgaaa gaaaacaaag aactaaggta accctaatag atcttgagaa agttgtcaat 284040 cattataagc ctcagcttcc tcataaaata tgtatgtatg gtactacctc acagggctgt 284100 tctttggatt taaagtactg tattagttag acatttgtca ttcattcaat tcattcagca 284160 aatatttatt atgttctttt ctcaggccag tcagtgttct ccatactggg gatagaaact 284220 gtcttccctg gtgggatcta atcccagcga gggcggaaag tgacaatgct atggagaaat 284280 atagaaaagg agaataggag tgttgaagag gttgcagtgt tgagttttca ggattggcat 284340 ccctgagtca gtggcatttg aataaagaag gattagagag gataataatg tgtgtgtctc 284400 agggaagggc atttcagcaa aggggcacag ccagaggaaa gatctcaaag tagaagcatg 284460 cttttcctca ctcagtgaac agcaggcagg cggtggggtg ggcacagagt gagcgaggag 284520 actggtatga gaccaaatgc cacagacaag acagtcaaat ctacccaacc attgtaatga 284580 ctttggcttt cacttggagt gaggtaggaa gcctttggag ggttttagat gatgagtgat 284640 gtgatctaat gtgttaggat aatcactgcg tcatttcact tgacgattgc atggagaata 284700 gactggaggg ggacaaagac caaaggagta cagtggggag acaaatgcag caagaagaat 284760 gaaaaaggat aatggctagg accaggttat agtggtgcag gcggtgagac atggttggat 284820 tctgttatat cttgaaagta cagctgatgg aatatggatt agtgaggcaa aaatgagcca 284880 aggacgagtt cattgttttt atcctgagca actagaggaa ttgagtcctc attaacagag 284940 atgggaaaga ggaaaggaga gcaggttttg gagaggaaga gcaaaggttt gtttggggat 285000 atactaagtt tcagatattt ttaaaatatc tcacaggaat tgtcaataca gcatgtagat 285060 gtatgtgtag aggtaaagga gaggtcatta ttatgcctgt aatggtgata ccaagccttt 285120 tccaaaagga ccttgtctca tatcctctat ttttcaaatg tagcgtaagt aataagttat 285180 aaaaaaaatc ttccattaaa accagtttta tagtttggtc actttaaagg gttgagcttt 285240 gattatcagg attcctgaat ctccaacaaa tccagaaagt tgaggaatta ctgccattgt 285300 atcggcatat gtagtttggc cattttgcat atccttccaa tttaattttc aaaatgtagt 285360 catgattcat caaattttga ctctccctgt ttttaaaaag gtggtgtcga ccccagaggg 285420 caacagcatt ctcctccacc ataaagcctg ttttcatgtg ggtgcacaca agagcttccc 285480 tctttggcca ccagatttga cagtcagtaa gagctcctca ctgtgtgtat ctgtagagtt 285540 atctccagtc aaccctaggg atgcacactt tgcaacactc taggtggcct tctgtatatg 285600 acagaaaaac tagcaataat ttaccgggaa ccatctagaa tataaattta gacatagttt 285660 ctggctttga aatccatatt tttcttcatc agcctttgag aaattgtggt ctttgaggtc 285720 ctaataagca gaatgcaaca aattttcctg ggactgtaga gtatatcagt agaacctgag 285780 gaaaacagtg tttcaagttg ttcatgtgac agttaagaaa aagacagaaa acactgaatc 285840 gtcaccattt atgagactag cataatgcct tcttccttct tatgtcagaa gaaaacatca 285900 catgtggcta ggaagaccac aaagctaggg agcgttagca gcgtgtgcag gaagatcgta 285960 tgagaagatt gaagaagagt gaaaaaggat aatggctagg accaggttat agtggtgcaa 286020 gcggtgagac atggttggat tctgttatat cttgaaagta cagctgacag aatacggatt 286080 agtgaggcaa agatgagcct ttcggggaac aacacagaaa tgagataaat gaggtatctg 286140 cccccaggcc atacatagtt gcaagaaaaa agatttctct acccctagtt ccacagcagc 286200 ctcatgtctc aattccgtag gtttttctga ctctgttttt tcagtttcaa gcgaaaatga 286260 attcatttgc caaaatccag atgcatttat gatatcagag caaaaagaaa tataaaacat 286320 ggcagatctt gaaaatattt tttggcagat tttttgctcc caaaggaatt tttgtaaggg 286380 cttatttaaa agttaaaaac aagtcacttt tgcgttaaaa aaagttactc tcttataaag 286440 tgaaagttat aataagaaaa atattggaag aaataagagt atgaacgatc aaaaatatag 286500 aaagtaattt ggtcttctga gaagaatgcc ttccattaat aataaattgt gtctgtctgt 286560 gtactaatgc tctgttgaat tgcacagtgc aaccagatcc acccattgcc ctcaactgga 286620 ctttactgaa cgtcagttta actgggattc atgcagatat tcaagtgaga tgggaagcac 286680 cacccaatgc agatattcag aaaggatgga tggttctgga gtatgaactt caatacaaag 286740 aagtaaatga aactaaatgg aaaatggtaa gatgtcacta caccttacac tttgactttt 286800 ctttctattt catcaacctc tctctcattt atcattagac tttcttttga cctaatacca 286860 catgttcatg ctgtatgcgc cataatttct tatttgagaa aacatgattt aatcggtaaa 286920 atatcttgaa attctgttaa gacaggagat gcttatgtat atatggaggc ctgtggaagg 286980 aaaggaaaac tatttctcca ttcattcttg aggtccagtt taactttaga gtaaaattat 287040 agactggcca cttatctgtc tttggggatg tggataaaaa tggaaaagtt tgtgatcaaa 287100 gtcaacagtg actatggcca aatattttcc catgatttca gttgctgcta ctcaaaagac 287160 tcccattaaa acaaattcat acgtgtttac aggaaacaga ggaagggaat ttgtctctta 287220 gaggtttcag aaggatgttt tgttacatac ctcagagaag aatcaagctg agattctcac 287280 gtaggcaatt agagagcatg gtactggtta acctctgaat ccctctcttc cttaccaagc 287340 atatggaact cagcacttcg ataaaattca catggcacat aacaagagga aaaacaggag 287400 tatcatgctg ctcccaatat aactaattct aaatctgtct aaccacagcc acaggcacag 287460 ccaaaccaag cagtttctgg ccactcatca ggtgatgccc agcagcctgg cacagatcac 287520 tcccagaatt ttgagacacc aggacattca gtgaaccact gaaaaagatg ccaattttgt 287580 cattagaggg aagttaagtt tggagatact ttgagtagtt gcaatactgg actttggggc 287640 tctattttct gaatcatttt aatgtagata tctgttctgt aacttggtac aaataaaagt 287700 cctggttaga tgctaagtca aacaagactg tctacatcca agctacaatc aaacattatt 287760 cagcaacagg tactgaaata actactatgc agaaggcact gtgctaaata cctgaggtgg 287820 cggttctcaa agtgggaacc acagacccct gagggtccct gagacccttt cagagagttc 287880 agtactattt tcacaataca ctaaaatgtt attttattca ctatgctgaa atttaattta 287940 atggcacaaa agcaatgctg gaaacactgc tggcacctta gcatgaagca aggcggtagg 288000 atcaaatttt actaatagtc attatattct tcatcatcat gcactgacag taaagaaggg 288060 ggaaaaagct agtttcatgt atgatgttct tgatgaagct gtaaaaattg ttaattttgc 288120 taaacctcaa cctttgagta catagcttat taatattctg tgtgacatat gggaattaca 288180 cattaagcat gtctgctgca tactgaggta ttgtatttgt cttgaagaaa agcgcttaaa 288240 tgactgagct gccagctgaa ctagttgctt ttattgcttg gagcaccatt tttacttgga 288300 agacaactga taaactggca gatggttatt catatttgaa ttggcaaaca tttctcaaaa 288360 aagaatgagg tgagcttgtt gcttcaagaa aaacaactga ctgtattttt tgccatggaa 288420 aaaatttgac ttttcaaagc aattcatttt gcctttttgg aaaatttggg tctccaaccg 288480 tgagcttgat agtgttttaa tatttgaaga cttttcttga agagattcat ggtgatatta 288540 atgaaagtga ttttttagtt gtattgtgta ataaaatgta tgaaatttag aaaaatctac 288600 aagtcagtga accaatattt tccaaatgac taatatatta tgtaattaaa tcatgcatgg 288660 ggaaatgatc cattaaaagt actagataga atggtgaatt tttttaatga tcaaaaaatt 288720 ttttgtatat ttattgtgta caactttttt tgaaatatgg atacattgta gaatggttct 288780 atcacagtaa gtaacatgca ttaccacaca caccattttt tgtgtgtatt gagaacactg 288840 aaaatctact cacttagaga ttttcaaaat acaatacata ggcattaact atagtcatta 288900 ttttgtacaa tagatttctt aaactcgttc ctactaactg aaaattttag ttctttcgtc 288960 aatatctcct caactctcca ccctacccac aacccctgat aaccaccatt caactctcta 289020 cttctgagtt caactttttt agattctgca tataagtgag attatgtggt atttattttt 289080 ctgtctctgg atcatttttc ttaatataat atcctccagg ttcatccacg ttgtcacaag 289140 cgacaggata tccttctttt tttaaggctg atagcattcc attgtatata tatacaccac 289200 attttcttta tcaacttatc cattaatgga acataggttg attctatttc ttggctgtta 289260 taagtaatga acatgggagc ccagatattt cttcaacata ctgatttcat tttccttgga 289320 tatatactta gtagtggaat aatataatgg atcaggtggt agttctattt ttaatctttt 289380 gaggaagctt catatcattt ttcatagagg gtatactaat ttacactccc accaatagtg 289440 tgcaagggtt cccttttgtc cacattctca ccaacacttg ttatctcttc tttttttgaa 289500 aatagccatc ctaacatctt tgtgcactct atgccttctg tgagctgata gctcattgtg 289560 gtttaaattt acacttccct gatgattaaa gatgtcaagc atttttcata tacctgttgg 289620 ccatttctat atcttctttt taaaaaacta tattcaggtc ttttgcctgt tttttaattg 289680 ggttatttat tttcttgcta ttgaattggt ttagttcctt atatatttca gatattaaac 289740 gcttatcaga tgtattcaaa tattgtctcc cattccataa aatgtctctt cactctgttg 289800 attgtttcct tggcagtgca gaagcctttt agtttcatgt aatcccattt atctatttcc 289860 acttttgttg ccttgcccaa tggagtcata tccaaaaaat cattgcccaa accaatgtca 289920 tggagctttt actctatatt ttcttccaac agttgtacag tttcaggttt tacatttaag 289980 tctttaatca attttgagtt tatttttgta tatgatataa aataagggta tgatttcatt 290040 cttctgcatg tggatgtcca attttcccaa caacatttaa agacagaatc cttcccttac 290100 tgtatattct gagcaccttt gtgataaatc aatttactat gaatgtgtgg atttatttct 290160 gactacttta ttcttttaca ttggtttatg taatgttaat gccagtacca tgctgttttg 290220 attactatag ctttgtatta tgttttgagg ttggtagagt gatgatttca acctttttct 290280 ttttgttcaa gattgctttg gctattcata gtctattgtg gttgcagaca aattttagaa 290340 ttgctttttc tatttctgtg aaaaatgaca taggaatttt gataaggatt gcattgagtc 290400 tgtagatcgc tttaggtagt aggaacattt gaacaatatt agttcttcta atccatgaac 290460 atgggctatc tgttcattta tttgtgttgt cttcatgttt tacagtttac agtgtacaga 290520 tctttcacct ccttgtttaa atttatttct gggtatttta ttttattttt atttttatag 290580 ctgttgtgaa tgggattttt ttatttcttt ctcagattgt tccttattag tgtatagaaa 290640 tactactgat ttttatatgt tgactttgta tcctgcagct ttactgaatt tgtttatctg 290700 ttctagcaat tttttgttga agtctttagg gttttctata tataaaatca tgtcatctgt 290760 aagcaaggac aatttaattt tttcctttcc aattttggat gccttttatt tctctctctt 290820 gcttaattgc tctgaatagg attttgaatt gagtagagta gagtagaata gaggagttac 290880 actgaataga agtggcaaga gtaggcatct ttgtcttgtt ccttgtctta gaagaaaagc 290940 tttccacatt tcactgttta ttctgatgtg agtttgttat acatggcctt tattgtgttg 291000 aaatacattc cttctatatc taattgttaa gggtttttat catgaaagga tattgaattt 291060 tgacaagtgc ttcttctgta tctactgaga tggttccatg gttttgttct tggttctagt 291120 aatgtgatgt attatgttta tgtatttgtg tgtgatgaat catccttgca tccctgggat 291180 aaatcctact tgatcatgga gaatggtcct tttaatgtgc ttttgagtta gtttcctggc 291240 attttgttta agatttttac atctgtattt atcagagata ttagcccata attttctttt 291300 cttgtagtgt cctttcatgg ttttggtatt agggtaatgc tagcatcaag aaatagtttg 291360 aaagtatccc cttttcttcc attttttgga aaagtttaag aaagattggt gttccagtga 291420 agcttccagt gaagctgtca ggtcctgggc ttgtctttga tgacagacat tttactactg 291480 attcaatctc tttacttatt attggtttat ttagattttc tatttcttca agaaaatttt 291540 agtcggttgt tgtgtgtagg aattgattca tttctcatgc atataatttt tcagaatggt 291600 ctcttatgaa catttgtatt tctatggtat tggttgtaat gtctcctcct tcatttctga 291660 ttttgttttt agtttgagcc ttctcttttt ttttttatga tttagtctag ctaaggattg 291720 gttgatttta tcttttcaga aaaacttgtt tcgttaatct tttctactgt tttaatgtgc 291780 taactcaaaa gcacattaaa aagatcattc tccatgatca agtaggattt atcccaggga 291840 tgcaaggatg gctcattaca cacaaataca taaacgtaat aatcacatta ctagaaccaa 291900 gaacaaaacc atggaaccat ctcaatattt tctactctct gtttcattta tttctgttct 291960 gatctttatt atttccttcn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 292020 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 292080 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 292140 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 292200 nnnnnnnnnn ttctgactgc tgtgatgtag tatctcatta ctgttttttg atatgcctct 292260 ctctaattat tagtaatgtt gacctttttt ttcatacact tgttggccca tgtttgtgtt 292320 cttttgaaaa gtgtttgttt atggcttttg tccacttttt aatgagactt ttttttttgg 292380 cttgttgatt tatttaagtt ctttatagat tctggatatt agacctttgt cagatgtata 292440 gtttgcaaat attttcagcc attctataga ttgttttttc aattgtttct tttgctgtgc 292500 agaagctctt tagtttaatt agatcccatt tgtcaatttt tgtttttgtt gcaattgttt 292560 ttggcatctt tgtcatgaag tctttgctat ggcctatgtc tggaatggta tttcctaggt 292620 tttcttctag ggtttttata gtttggggtt ttgtatttaa acctttaatc catcttgagc 292680 tgatttttgt gcgtgttgaa aggaaggggt ccagtttcaa tcttctgcat ataactagcc 292740 agttacccag caccatttat taaacagtgt tttcctaatt tcttgttttt gtcaactttg 292800 tcaaatatta gttggttgta ggtatgacac tttattttgg ggttctctat tctgttccat 292860 tgatctatgt gtcttctttt ttaaccagta ccatactgtt ttggttcctg tagccttata 292920 gtataatttg aagtcaggta atgtgatgcc tctgggttta ttctttttag ttaggattgc 292980 tttgactgtt tgagctgttt tttgcttcca tatgaatttt acaattgttt tttctaattc 293040 tgtgaaaaat tgcattgata atttgatagg tatcacattg aatgtgtaga ttggctnnnn 293100 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 293160 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 293220 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 293280 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 293340 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 293400 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 293460 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 293520 nnnnnnnnnn nnnnnnnnnn nntttcaatg tcacacttac atctttttat atggcatatt 293580 tcttaacaaa ttattatacc tagtgttatt tttaataatt ttatctttta acatttattc 293640 taaaataaaa gtgatttaca tactaccatg aaaatattag actactctaa attggactgt 293700 gtgcttactt ttaccagtga gttttatact ttcatatgtt tttatgttat aattagcctc 293760 cttttctttc agctaaagaa ccccctttag cagttcttgt aagataagtc tgttggtgag 293820 gaatggttaa tttaaatata acaaagtaca aaaagttcat tggtagagtt tcaggtttca 293880 tatttccact aacctttaag aaactatcat ttgagtttag tctgttatta aacagaaatg 293940 ttcacaatta tgtgaaaagt ttattaaaat attcctcctt ttcctcatta tttatctgtg 294000 tgaggccagg ttttattcat ttacatcaac caaaatagca cattctaata gatttaattc 294060 agaagcagtt ataaaaatac agtcatcttc aagtctgaca ttaaataaat ttgcaaaaat 294120 gtaaaacaat gtcactcttc tcactctatt ttttattgtt tgggaaagca caataatttt 294180 tatgaaaata ttattttaac aaaatcaatt tattattttc attttaaaaa ttaggattta 294240 aaaatttttc catttcaatt tctaatacgg taactagtga taggtataac ccaactcaac 294300 caaaatcttt aggattctca aatgtttaag agtgtaaagg agtcctgaaa caaaaaagtt 294360 aaacaaccta gaaaaaaaca aagatattaa tcagtatgat agcattcatc gattcaatta 294420 ccatcatggc atccctaaaa gcccatggta tatagttaca tctcactgag ccaccacttt 294480 gaaactccca ccctgcacca ggtacttgtg agcgtgtaac tttgttaatc aactgttcag 294540 ggctgtatcc caacatggct ttgctgcact ttttgtggca cctctggtaa atctcattag 294600 gtagaccaaa gggatcagtt aactttttct ttataacttt tatttacgat attttataag 294660 tttggtaatt tgcaaaggtc ttggacaaag accaggggct tatcaataat aatttatctc 294720 ttgaagaaac aaacaatata attggttatg gagcacaggc atcataagca gaaaacaggt 294780 ttataagtaa agggggaaaa cctagtgtgt gttgcttgca tcaggaattc atgttaccat 294840 ttggcaatat gaatttgctt agcagtgtgc agtgtgcttt tttttttttt tttttttttt 294900 tttttttttt ttttgacagg attttgctct gtccccaggt tagagtacag tggcccaatc 294960 tcggctcact gcaacctcca cctccagagt tcaagtgatt ctcatgcctc agactcctga 295020 gtagctggga ttccaggcac aagccaccat acccagctaa tacaactaat ttttgtactt 295080 ttagtagaca cagggtttca ccatgttggc cagactggtc tcgaactcct gacctcaggt 295140 gattcaccaa cctcagccta ccaaagtgct gggattatag gcatgagcca ctgcatccag 295200 ccaccctttt tagtaaatac attttgcatg accgtgtagt tgtttacagc tatttatcta 295260 gtaaaccaat aacttacagt tttttaaaga cttaatggat agcatggaat tattcatgat 295320 atctgcgcca tatcttgagc acccactgta tacctgatgt tgtactgggc tttggaaatg 295380 aaaaataatg agttatcttg gggaatttac aatgtaacat agaaagcttg tataactaaa 295440 tttgcacaat gaaatataat taatgataga agaagtatat tatctggcag agcagagtgg 295500 ggaaaagtac cagcaaagac ttagaatatc agctgtcctc aatacttgca cttagacttg 295560 gatgagaaac agttccctgc acaagcggat gacagggtta ggtatgatag gagccatgta 295620 agtaggagcc actcaaaatc tgagtttggt gtggctggtg tggagggttg agagaatatg 295680 aagagaggac cacaacttga attactgagg gccctttttt gattctatta gtgaaatctt 295740 taaagaaatt gtattggtga cagtaacaga gaaataaggg ctttgaggat gaaaacatag 295800 gctaaaaaaa aaaaaaaaaa aagcctaaga aaaaataata aagttcagta ttcagtgtcc 295860 tgccttaaaa gcattttagg catgcaaata tcccatatat tcagaagatc ctataaaaaa 295920 tataaacaaa ccctgtcata tacacatgag gcagaaaaaa gatactttgt gagtagaaac 295980 taattgaggt aaaagaagaa gaagaacttg ttttagaagc tgaaggccca gctgctgact 296040 taataaaaca aattatgaga attttattta tgtgaaaatc catcctgttg aaaaaccgag 296100 tgtttaaagt tttctataaa cagcaacaag gtgttctacc aaaaatatat atatatatga 296160 aaagcacatt gaatacctgc tttgagtatt tgacttggag gaaaatagca tcactagttg 296220 agtatctctt tgatagcaat atgtgttaaa agtctaacaa tctcactcta cccttccctg 296280 agaacgtaaa ggaatatcct aaccttaagg gttgtgagac ctagatattt cttaccaaag 296340 aactcctgtg actctttatt gcaaatttta aatagcaaac tgttttgtgg tggcttttag 296400 ccttccagaa caagcgtatt agatatgtag ttccttttaa taaaagtatt tggaagttca 296460 ataaaggcaa ttatgatttt tctaggacct tttccaattc tgttattatg tgaatgacta 296520 cccagaattt ccatcaaaca ctgatataca acttgctatg gctacaattt attttggtgt 296580 ggaaatatgt ttgtttttct gttcttatgt ctcccttcat acaaaagtgt aatatcccgg 296640 atatgtagac atatagttct gccattcaga gtaattctaa tatgctttaa tcttattaac 296700 tatctggaag actaatgcac agctgtagct gcatttcttt aagtgagtct atcatatatt 296760 tgggtttata ccaaactaaa tttgtgaact attatccatt taaaaaatga ttatttacat 296820 aattatttgc cttaatcttc ctttaaatag caaatgctca cgatgcattt taaaatatta 296880 cctactttat aaaaatccat tctggatgca aatgggggaa tacctgtagt gtttattgca 296940 ttgagttgtt gattctttag ccaatatgca tttatatttt gtcttgaaag atggatccta 297000 tattgtcaac atcagttcca gtgtactcat tgaaagtgga taaggaatat gaagtgcgtg 297060 tgagatccaa acgacgaaac tctagaaatt atggcgagtt cagtgaggtg ctctatgtaa 297120 cacttcctca gatgaaccaa tttacatgtg aagaaggtaa aagaaataaa agattaaaat 297180 agcagctaac ctggcttttg tcaatataac agttgattca accctgcact gttagtgtgt 297240 tgtccagatc aaaatatatt agcatcagat atcacggtga gagaccttga gctcaacatc 297300 tgaaacagat attgttcatt gcaaaagcag aaggaagatt tagtttccaa atttttcatt 297360 caggaaatgt ccgggggaca ggtggaagtt tagagacagg aattcggtgg caatctccag 297420 atggtacaat tcagatgatt cttttcttta tatatgttta tgttcccaaa attttctgta 297480 gtaagtttgt tttgaattta taatcaggaa aaaaaaaagc tgttctgatg attagggaag 297540 aaagtatgtt tctatatgga tggagagata tgtggcatct aagaggaaac ctaatattga 297600 gtcggcatag gtagtcaaca gcagctgcat aggttttaga aagtggaggt atggcttttt 297660 cctagaggaa aggctaataa gtagggtggc agtcatactc aaaggagaca tggaacattt 297720 gaaaaccgta tgtaggagaa tcacaacaat gattaaagtt ttttaaaatg ggacctatga 297780 atttagaata aaagaattaa aacttttaga tacagaaata aagaaaactg attaataatg 297840 agcagaaagt atagagtatt atgattctca aatgggaatt ggctctattc tatcttcact 297900 gaaaacagac gtttacaggg ctatatgttt gttaatgaga taaccacaag ctacatagaa 297960 aataaattta tatttctgca tttactatac aggtagaatc tcatgatact aaatagcact 298020 agaatgaaaa tttctgtagc accattttct ctaaactcta gttaactgac ttcttgtttc 298080 caaactattt gatataatgc aattctggtc ttaaaagtat gatagctgta cacccttaag 298140 cttagtgtag tggcatttaa ttcacttaac atatattttt taaaatgtct tttcctctgt 298200 tactaacaaa aaaagaaact ctaactttat gttattttcc tgaatatgtc actgatatga 298260 aattagagat actacaagac aaaaaatgat ttttttctcc cccaccaatt ctttaaaatg 298320 cttatattat ctccctaggg gattttaata acttattaaa taagaaaaga ctatttcagc 298380 ataaaggcct acattttcaa tggcaatgtt cagataaatt tcatctgtca tttctatgaa 298440 aaagtggtta gcctctgtct ctgtggtaag aatactggga accaactgca aagtagctgg 298500 caggtactta atcttaagga atgaaataga agttttacaa acaggttccc ccaagtctca 298560 tacaaagtat actaaaacct gaagatggga gctcaatagt gatctttctg tcaattttat 298620 gtatataata tacatgatat atatttatta tattttaata atttaatttc ttgatataaa 298680 tatgtatatt tatagctgta aaatatatgt tctttgtgtc taagaagttt ctgtcatgat 298740 ttatcaataa aaactctgcc ttcatctttt tgataaatct tcaatctaga ggctatgata 298800 atcaccacac ttaaaaaaaa gtagaaaaga aaccaagtgg gcattattta ggtagtgtgt 298860 taataagcaa cactttttgc ctagagctga aacctttatg atactccctt gacacataat 298920 atgcttaaag cagattgttt gttttcataa aacacactga ttttgcacta tatgctgttt 298980 ctttattttg aagttttttt aatgaggaga tttgaaaagt ggacagagat gttcataaaa 299040 cagaaaaaaa actaagtcat tgcattctgt ttcagtggtt atcaagagaa atcagtggct 299100 ttattagatg aatacaaact gaattttttg tgaaaaggga aagggaaatg taaactgtgc 299160 ttcaactatt tgtaattctg agagcgaaat attattgtgt gtttcagatt tctactttcc 299220 atggctctta attattatct ttggaatatt tgggctaaca gtgatgctat ttgtattctt 299280 attttctaaa cagcaaaggt aggtgtgaag tagtattctt tggtattttt tgccagttgt 299340 ttagatttcc atgtgtgttt ctatttgtta tttgatattt tctttgtcaa attatgagtg 299400 gaaattttag ttaacctagt aaacttttat ctccagttat atatttacca tttatataaa 299460 acccaatttg ttgtatttat catagacaac ttagaggttt agattctatc tggagacttg 299520 tacaggacat taagaggctt aggctggtga ctatgcatac ctcgtgatgt gtacctcttt 299580 atccaagagc tagctcttcc cctcgagtcc tcaacaagtt tacccattca ttccagatct 299640 tcagagtatc actgagcctt tggctgagtc tgatacagtc cttatatata gacatttttt 299700 tttccttgag atggagtctc actctgttgc ccaggctgga gtgtaatggc gcaatcttgg 299760 ctcactgcag ccgctgcccc ccaggttcaa gtgattctcc tgcctcagcc tcccgagtag 299820 ctgggattac aggcacccac cactatgccc ggctaatttt tgtgtgtttt tggtagagac 299880 agggttttgc catgttggcc aggctagtct cgaactcctg atctcaatac acaggcaaaa 299940 ttttaagtgg caaactaccc aggtagatag ttaagtctaa taaaacattt tttagacttc 300000 atatgatgat gatttcaagt aaattcaggt ttaatttaaa ttatttggat atttatgatt 300060 ttgtgtttca cctgcattta taaacacagc taaaagtctt tataagtgta aagagatttc 300120 attccacttt ctcttggaat caaaagcctt gagttccagt tatcattttt gtcattgctg 300180 tttgaccttg tttgagtccc agaatctctc caggcctcca tattcttatg gttaatatga 300240 gggtatgggt tatataatct ttaaattttc cttgagctat gatatatgtt atttatatta 300300 ttccattttt cttcctgata gaaactcact acacactaca ggaaattttt ttaaacaaaa 300360 tatgggaaaa atgattggta ctgattgcca gtgtcctaca tttaaggttg ttttgtttgt 300420 ttgtttgttg tttttttctt tgttttgttt tgctttgttt tgtttttttg agatgaagtc 300480 ttgctctgtc acccaggctg gagtctggag agtgcagtag cccaatctca gctcactgca 300540 acctccacct cccaggtcaa gcgattctcc tgcctcagcc tcccgagtag ctgggattac 300600 agggatgtgc caccacgccc acctaatttt gtatttttag atagtttcgc catgttggtc 300660 agactggcct cgaactcctg acctcaggtt atccgcccgc ctcagccttc caaagtgctg 300720 ggattacagg cgtgagctac cgcgcctggc cccatttaag gtatttttaa agtcccaatg 300780 gttaaccttg cttcttctcc tagaactaag gtgactgaca ctcccaggtt gcctagagct 300840 ctcctggttt ttagcaatgc aagtcctgtg tgccaggaaa tccctcagtt ccaggtaacc 300900 aaggcagttg gtctccttac ctagaattga aaataggttc tccagctgaa gccaaaaggc 300960 atctataaat caaaatgaga tctatgttaa tatattttaa agtattttaa tttgttttgt 301020 aacgtagtat aacatttgta aacttcaaaa tagaattttc ttaggaagaa gaattattgg 301080 gacactagag ttctcgagtg tcaagcatgc taaaagtcta actgaatgca gaaagggtta 301140 ttttcagtag agttttatgt ccaattttat aatataaacc aatgggaaag taaaattcat 301200 tctgcagaat tccattttgc acctaacttt ctggcaacat ttctattttc caaaaaagca 301260 gctatcataa atcacaatac aattttctgt tgtttcagga aaataaataa atatattttt 301320 agatttttaa tttgtgtatt taagtaatgc caacaaaaaa agaaccaaat tattctgttg 301380 attaatttca gttttttaat ctatctatct tgtggggaaa tttatacata acttcaatag 301440 ataaactcac gaagtatata aagtaattat ctcttagtat tagttgtgaa tttctagcca 301500 ttgtgaaggc caagtcaatt tgttatgttg tttagttata ttagctaaca atattaggaa 301560 gaaacaatta tcctctcaaa aagtagaatt tccaagaaaa catattactt ctaatagagt 301620 gctttttata aataatgaaa ttcttaacta taatgtttag tcagaatcac cagattctac 301680 aattaatttg aaatctttat tgttctccca attttcctgc actaaattga attttctgta 301740 ggaaagaatt aacttttttt tcatttgccc aataaaaacc cttatcgttg tctaaatttg 301800 catgttctac tgaaagtggg aaatagtagc aaatatttgt cagcaagtat ggacagaaca 301860 tgtagttcca acaattaaat tgatactaca aagaatgaga tttttcttag aactgtaggg 301920 ctgtaaagtg gcttcaggtc ctacacgcct ttgaaatttt gtgagtccac aattcattat 301980 ccaacccact tcaccctgct ttaatccagt tacttgagtc aactctagca aaatttataa 302040 ttttatttgt atctgataca aaatcacaaa cttagtttca agtcaggcta tactggttcc 302100 taccacacaa cccacccagc ctttgagctg ttaccaattg aggaaagaaa taactgaatc 302160 agcccaaaat agaacttcca aaccaatagc caaattcagc ctacagattc acattttatt 302220 ttattttaat tagttttgat tttagagtga agattttcct acaaagtgtt tgtaaaatac 302280 agaattttca cacaaaaatc cagatttggg gattatcttt taaaaaatga aagatgtagt 302340 gaaactgaat aaggcggcat atgctgcagc agacaaccag ctgtcctatt tgggactggc 302400 acacattctt taatgtgcca ccatcctcat tcctcctaat gactttgcaa ctggcttgct 302460 ttattcatct gcatgatctg cttgggcccc ttagatttat ggtctgccac tgtgacataa 302520 ggtcactaca acccctagaa aaccactagc acatgcctga atgcatcatc ctattcaaaa 302580 aggagaagca cacgtcacaa agtcaaacat cagccatttg gaaacctttg cttcctgtca 302640 ttagagttat gttccatctt tttatgtttt ggagaatgtg aaatatcgat ttagagatgc 302700 agaatcaaga aaaaaaaaaa aaaacagcaa aacagcagca tgacgcaaag aacctgggtt 302760 ttggtttgga gtcaggttct ctgggtttga gccccaactg tgccaactat cagtgcatga 302820 tttgaacatg ttccttaatt ttccaagttt ttgcacatat atatcatctg cctccctggg 302880 agtcataagg attaagtgaa atgtttagtg caggggtcac aaacttattt catggagtca 302940 gagtacattt ttatgctttt caagccatac agtatctgtc acaactactc aactctgcca 303000 ctgtggcatg aaagtggcca tagacaatat ggaaatgaat gaagatgctt gtgttctcat 303060 aaaattttat ctacacaaac aggtgacagg ccagatttgg cccatagacc ttaatttagt 303120 gacccacagt ttagtgcaaa atatatccca cagcgtctga tttatcagaa gcactaaaaa 303180 atgagagtag ttattattaa taatttgtat tgcttatttc tatatctgta attcattagt 303240 aagaatttgc tttaacattt gccccactga gtagtagagg ctacttaatg caatttataa 303300 aatggaattt cccttattgc ttggattagg taaaatggca agtagaaata ttgagagaat 303360 gtattcctta tgtaatggac tagactgacc attcacactg agtggaatag caactgatat 303420 ccaaaaatca ggttaccacc tcttcatgac agtgtcatct ctgaatagtc aggagttttt 303480 ttaaaagtta aatgaattgt ttggaataat atctgagcct tttttcagtg ctataatttg 303540 atttttaaaa ataaactcag gccgggcgcg gtggctcacg cctgtaatcc ctgcactttg 303600 ggaggccgag gcgggcggat cacgaggtca gtagattgag accatcctgg ctaacacggt 303660 gaaaccccgt ctctactaaa atacaaaaaa ttagccgggc gcggtggcgg gcgcctgtag 303720 tcccagctac tccggaggct gaggcaggag aatggcgcga acccgggagg cggagcttgc 303780 agtgagccga gatggtgcca ctgcactcca gcctgggcga cagagtgaag actccgcctc 303840 aaaaaaaaat aaaataaaat aaaaaataaa ataaaataaa ataaataaaa ataaaaataa 303900 actccaggcc agatacaatg gcttatagca tataaatcca gcactttggg aggatggggc 303960 gggaggattg ccctgaggcc aggagttcca gacggctcgg gcagtgacta gagcaagact 304020 ccattacaaa aaatgaaaca ataaaaatta gcctaccctg tagtcttagc tacttacgag 304080 gctgaggcag gaatatcgct tggcccagga gtttgaggct gcagtgaatt atgattacac 304140 tactggactc caacctgggt gataaattaa gatcctgtct caaaaagttt aaaaaaaaat 304200 taaaaacacc ataaactcca attacactat taattgtaca aaatagatac atgattaatt 304260 catttttatg accgaaaaat aatttaaaga tttgcaacag aaaatgtaaa tgcatccttg 304320 aattgtgtat ataaacccat actgattagt tagagatagt tcaaatttag tctgtcccat 304380 ctgaaatgaa tcctctagta aaaccctgtt taataagatc atcttagata atttcataat 304440 taatatgaac tatatagcta acctacccaa gtctaccctt tttcaagggt gcaggtaatc 304500 ttggctccat gtgtattgac ccttttctcg ttctttcttt tctgtacaaa ttactgatga 304560 gatgtacact ggaattgcct tatagctgac atggaaatca gcttcagatg aaattaaatg 304620 tcttactttc aaatactata tctggctgaa aataaaaaag cattaagaaa aaaaggattg 304680 tgggaaaaac acattttctt ttaatagacg tcagatgagg tttttcgggt tttttaattg 304740 ttcttttttt tccttctaca atttttcttt ctcatttgct gtctaatatt ttcttctgtt 304800 tctcatactc caattatata aagtaccaga atatttggga aagtaatagt attgccaata 304860 ttttatttct atcttttgct attattgaga atatgtagct tttaagatgt caaaaccaaa 304920 attttatatg ttttcaagga ttaaaatgct gattctgccc ccagttccag ttccaaagat 304980 taaaggaatc aatccagatc tcctcaaggt aattaataat tttatctaaa ttgtggccag 305040 tactaattaa cacctgaaga atcctgtcat atgtttaaag ttttctgtga gctatatata 305100 tcacattcaa ttttcttgta tcttgtctcc tagagaaaat tttttaaaat attctctctt 305160 aaaaataaga aaatgtcata tgtataaaaa gttatgcact aatttatgtt ttgtgatatg 305220 ttttgttact gttgttctta ttgtaaccat aattaatctc tgaacatcat ttgctaattc 305280 atttaattat tatgagtttc ttttcataga tcttcatttt ctttctattt tctaggaagg 305340 aaaattagag gaggtgaacg caatcttagc cattcatgat agctataaac ccgaattcca 305400 cagtgatgac tcttgggttg aatttattga gctagatatt gatgagccag atgaaaagaa 305460 tgagggatca gacacagaca gacttctaag cagtgaccat cagaaatcac atagtaacct 305520 aggggtgaag gatggcgact ctggacgtac cagctgttat gaacctgaca ttctggagac 305580 tgatttcaat gcaaataaca tacatgaggg tacctcagag gttgctcagc cacagaggtt 305640 aaaaggggaa gcagatctct tatgccttga ccagaagaat caaaataagt caccttatca 305700 tgatgcttgc cctgctactc agcagcccag tgttatccaa gcagagaaaa acaaaccaca 305760 accacttcct actgatggag ctgagtcaac tcatcaagct gcccatattc agctaagcaa 305820 tccaagttca ctggcaaaca tcgactttta tgcccaggtg agcgacatta caccagcagg 305880 tagtgtggtc ctttccccag gccaaaagaa taaggcaggg atgtcccagt gtgacatgca 305940 cctggaaatg gtctcactct gccaagaaga cttcattatg gacaatgcct acttctgtga 306000 ggcagatgcc aaaaagtgca tccctgtggc tcctcacatc aaggttgaat cacacataga 306060 gccaagcttt aaccaagagg acatttacat caccaccgaa agccttacca ctactgctgg 306120 gaggcctggg acaacagaac atattccagg ttctgagatg cctgtcccag actatacctc 306180 cattcatata gtacagtccc cacagggcct catactcaat gcaactgcct tgcccttgcc 306240 tggcaaagag tttctctcgt cgtgtggcta tgtgagcaca gaccaactga acaaaatcat 306300 gccttagcct ttctttgatt tcccaagagc tacgtattta atggcaaaga attggctggg 306360 gcaataatgt ttaaaccaaa acaatgttta aacctttttt gcaggggtga cagggtggga 306420 tatggattct aaaatgcctt ttcccgaaat gctgaaatat gatgttaaaa aaataagaag 306480 aatgctcaat cagatagata tttctattgt gcaatgtaaa tattttaaag aatggtgtca 306540 gactgtttag tagcagtgat tgtcttatta ttgtgggtgt taatttttga tactaagcat 306600 tgaatggcta tgtttttaat gtgtagtaaa tcacgctttt tgaaaaagcg aaaaaatcag 306660 gtggcttttg cggttcagga aaattgaatg caaaccatag cacaggctat ttttttgttg 306720 tttcttaaat aaaaaaactt ttttatttaa aaaattaaat taaaactaga ggtgagaaaa 306780 tcaaactgta agcaagaagg caaaaatagt ttggatatgt aaaacattta ttttgacata 306840 aaattgataa agatattttt aataatttag acttcaagca tggctatttt atattacact 306900 acacactgtg tactgcagtt ggtgtgaccc ctctaaggag tatagcaact acagtctaaa 306960 gctggtttaa tgttttggct aatgcaccta aagaaaaaca aactagtttt ttacaaagcc 307020 cttttatacc tccccagact ccttcaacaa ttctaaaatg attgtagtaa tctgcattat 307080 tggaacataa ttgtttttta aacaaatatt tttttagcaa atttttaaac aaatatttgt 307140 taatttagaa aactttaaag tgtttgcaca gatcaactta ccgggcacca aaagaagtaa 307200 aagcaaaaaa agaaaacctt tcttcaccaa atcttggttc atgccaaaaa aatacatgct 307260 aagagaagta gaaatcgtag ctggttcata ctgaccaaga tgcttaagtg ctgcagttgc 307320 acatggagtg agttttttag tgtgtgcaga tggtgagaga taagatctat agcctctgca 307380 gcagaatctg ttcacactca acttggtttt gttacataat tatccaggaa gggaataagg 307440 tacaagaagc attttgtaag ttgaagcaaa tcaaatgaaa ttaactgggt aatcaagcaa 307500 agagttcaag aaataggttt ttgtttcaca gcctataacc agacacatac tcatttttca 307560 tggtaatgaa cagaacatag aagaaacaag gttttcagtc cccacagata actgaaaatt 307620 atttaaacct ctaaaagaaa ctttctttct cactaaatct tttataggat ttatttaaaa 307680 tagcaaaaga agaagtttca tcatttttta cttcctctct gagtggattg gcctcaaagc 307740 aagcattcag aagaaaaaga agggacctca ataatttaga aattattttg caatccctta 307800 atatcctaaa catcaggttt tgttgttgtt gttgttgttg ttgagatgga gtctcactct 307860 gtcgccaggc tagagtacag tggcgcgatc ttggctcact gcaatctcca cctcccccag 307920 gttcaagcaa ttcccctgcc tcagcctcct gagtagctgg gactacaggc acgcaccacc 307980 atgccaggct aatttttttg tatgttagca gagatggggt ttcaccatgt tggccaggat 308040 ggtctcaatc tcctgacctc atgatccgca caacttggcc tccaaaagtg ctgggattac 308100 aagcgtgagc caccgcgccc ggccctaaac atcattttta agagcattgg gatatttcct 308160 gaaaaggttt atgaaaaaga agaatctcat ctcagtgaag aatacttctc atttttaaaa 308220 aaagcttaaa actttgaagt tagctttaac ttaaatagta tttcccattt atcgcagacc 308280 ttttttagga agcaagctta atgcctgata attttgaatt ccctttcttg caggaagggc 308340 tatgaaaagc tagaattgag tgtttaaagt tcaacatgtt atttgtaata gatgtttaat 308400 agatgttctg ctactttgct gctatggttt tctccaagag ctacataatt tagtttcata 308460 taaagtatca tcagtgtaga acctaattca gttcaaagct gtgtgtttgg aagactatct 308520 tactatttca caacagcctg acaacatttc tatagccaaa aatagctaaa tacctcaatc 308580 agtctcagaa tgtcattttg gtactttggt ggccacacaa gccattattc actagtatga 308640 ctagttgtgt ctggcagttt atatttaact ctctttattt ctgtggattt tttccttcaa 308700 agtttaataa atttattttc ttggattcct gatagtgtgc ttctgttatc aaacaccaac 308760 ataaaaatca tctaaaccac tctgtatact gtgaattatc attgtaagga gagcttagca 308820 ccactggatc aaatacatca gccctgggta tggagatttt tatgggctgg gatatagaga 308880 gggaaacata aaccccttcc cttatttttt gaggagacaa aagcccagct cagaaatatc 308940 ctactggctt ggccctcccc ttaggctgtg actccccatg ggcaaaggtt catagagctg 309000 tgtatttgat gcatcataga aaataaatga catgggtgtg gagtgaggga gagtgacatg 309060 tgagcattat ctttatattt ccagcttgag catgttgtct ggaaggaagg aaagcagctc 309120 ttcctctgcc attcacccat tggcctaact cagtttattg gactagctgc ttgttatcat 309180 gggaatcagc taataagtca ggcttgggag aaaagctgat taggtaggtt gtgtaggagc 309240 ttgagagagc catgaagtat agattcctac aacaggaggc aggctgcagg tgaggtggct 309300 actgaaccct aggctcctga gcaggcactg gattctgaaa tgtaggaatc tggtgatgac 309360 attgataaat ctactaaaca atgaggtatt acttcagcaa gtcgaatgca aaatgccaca 309420 actttctata atactcaagg gttatattta aaaaaaaaaa aaaaagtctt catctgctgc 309480 cttctgccct gtgagcagtc attacctgaa agaactatgg agtgaagcct cagggattct 309540 tcatatggat gctttaaggt atgaggagta tagggaaaag gaagcctgcc tacttccatg 309600 gattgaaata acacagttct gtttcagaag attaatgatg tgttgaaaat ggctacacac 309660 gtttcagcat ttcagtttct caaagtttct aacactttat tcaagtgcta taatatttac 309720 atatttacat atttttatac caaaatatgt ctttttatgt gcttgttatg tgggtaagaa 309780 atagtgacca gaaaaaccag aagttactta aatataaact ttttagtttg gaatccaaaa 309840 tcccacataa tttgccccag tctcctttga cagtttagaa tttaagacct agatgtaaat 309900 atgtctggaa taggtggctt cttggtctca ctgacttcaa gaatgaagct gcagaccctt 309960 gtggtgttac agttcttaaa gatggtgtgt ccggagtttg t 310001 <210> 2297 <211> 24 <212> DNA <213> Artificial sequence <220> <223> Primer <400> 2297 cgagttcagt gaggtgctct atgt 24 <210> 2298 <211> 26 <212> DNA <213> Artificial sequence <220> <223> Primer <400> 2298 aagagccatg gaaagtagaa atcttc 26 <210> 2299 <211> 19 <212> DNA <213> Artificial sequence <220> <223> Probe <400> 2299 ttcctcagat gagccaatt 19 <210> 2300 <211> 27 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2300 gcgtttgctc ttcttcttgc gtttttt 27 <210> 2301 <211> 20 <212> DNA <213> Artificial sequence <220> <223> Synthetic oligonucleotide <400> 2301 gagacttttc cttgtacaca 20 <210> 2302 <211> 4178 <212> DNA <213> Mus musculus <400> 2302 gacaacccac gagctgccaa gcagggcgca gccatgggaa gaggaggcgg tctagggagc 60 ggcggcactg gcagaggcgg ctgctacagc ggcggtggcg gcgacggctg ttactgaacc 120 ccggcagccg cggggatccc gggctgggtc cacgcgggcc tgaggcctcg gctccagcag 180 cccccaagcg gacacgaacc cgcgttctgt ctcccgaggc gaaactccga ggtctcaggt 240 atggatcttt gtcaggtctt cttaaccttg gcactggcag tcaccagcag cacattttct 300 ggaagtgagg ctacaccagc tactcttggc aaagcttccc cagttctgca aagaatcaat 360 ccaagcctgg ggacaagttc ttctggaaag cctcgattca ccaagtgtcg ttcccctgaa 420 ctggagacat tttcatgcta ctggacagaa ggagataatc ctgatttaaa gaccccagga 480 tctattcagc tgtactatgc taaaagggaa agccaacgac aagctgcaag aattgctcat 540 gaatggaccc aggaatggaa agaatgccct gattatgtct ctgctggaaa aaacagctgt 600 tacttcaact catcatatac ctccatttgg ataccctact gcatcaagct aactacaaat 660 ggtgatttgc tggaccaaaa atgtttcact gttgacgaaa tagtgcaacc tgatccaccc 720 attggcctca actggacttt actaaacatt agtttgaccg ggattcgtgg agacatccaa 780 gtgagttggc aaccaccacc caatgcagat gttctgaagg gatggataat tctggagtat 840 gaaattcagt acaaagaagt aaatgaatca aaatggaaag tgatgggccc tatatggtta 900 acatactgtc cagtgtactc attgagaatg gataaagaac atgaagtgcg ggtgagatcc 960 agacaacgga gctttgaaaa gtacagcgag ttcagcgaag tcctccgtgt aatatttcct 1020 cagacgaaca tattggaagc atgtgaagaa gatatccagt ttccatggtt cttaattatt 1080 atctttggaa tatttggagt agcagtgatg ctatttgtag ttatattttc aaagcagcaa 1140 aggattaaga tgctgatttt acccccagtc ccagttccaa agattaaagg gattgatcca 1200 gatcttctca aggaagggaa gttggaggag gtgaacacca tcttaggcat tcatgataac 1260 tacaaacccg acttctacaa tgatgattcc tgggtcgagt tcattgagct agatattgat 1320 gaagcagatg tggatgagaa gactgaaggg tctgacacag acagacttct aagcaatgat 1380 catgagaaat cagctggtat ccttggagca aaggatgatg attctgggcg taccagctgt 1440 tacgaccctg acattttgga tactgatttc cataccagtg acatgtgtga tggtaccttg 1500 aagtttgctc agtcacagaa gttaaatatg gaagctgatc tcttgtgcct tgatcagaag 1560 aatctgaaga acttgcctta tgatgcttcc cttggctctc tgcatccctc cattacccag 1620 acagtagaag aaaacaagcc acagccactt ttgagcagcg aaactgaggc aacccaccaa 1680 ctcgcctcta caccgatgag taatcccaca tcactggcaa acattgactt ttatgcccaa 1740 gtaagcgaca ttacaccagc aggtggtgta gtcctttccc caggccaaaa gattaaggca 1800 gggatagccc aaggcaatac ccagcgggag gtggccacgc cctgccaaga aaattacagc 1860 atgaacagtg cctacttttg tgagtcagat gccaaaaaat gcatcgctgt ggcccctcgc 1920 atggaagcca cgtcttgtat aaaaccaagc tttaaccaag aggacattta catcaccaca 1980 gaaagcctta ccactactgc ccagatgtct gagacagcag atattgctcc agatgctgag 2040 atgtctgtcc cagactacac cacggttcac accgtgcagt ctccaagggg ccttatactc 2100 aacgcaactg ctttgccttt gcctgacaaa aagaattttc cctcctcgtg tggttatgtg 2160 agcacagacc aactgaacaa aatcatgcag tagcctttcc tatctttaat ggcaagggaa 2220 aggctgggca caaacgctta aaccaaaact atgttttaaa tctgtgttgg gagagcatga 2280 gagtggatat ggattctaaa atactttttc tggaaatgtc aaaatatcat aaagtggaaa 2340 atcaagaatt cgtaatcaga taaatgctcc cattgtgaat tataaatatt ttaatgaatt 2400 gtctttaaga ctgtatagtg gcagtgattg tctgtactgt gggtcttaat tttgtgatac 2460 taagcattaa atagctacgt tttttatgta tgtagatcat gctttttgaa aaagcaaaac 2520 aatcaggtgg cttttgcagt tcaggaaatt gaatgcagat tatagcacag gctgattttt 2580 tttttctttt ttaaataact gggaactaaa actctaggtg agaaggtaaa actagtttgg 2640 atatgcaaaa catttatttt gacatgaaat tgataaagat atttttaata atttacactt 2700 taagcatgag tactttataa tatgctacac acatattgta gttcagaaca atccatctaa 2760 ggatgtagca gctacagtgt aaagagggtt tcatgttttg gtcaatgaac gtaaagaaaa 2820 ccaaacaagt tagattttta caaagccctt ttataacttc caaaacttct taactctaaa 2880 aatgtctaat aacctgcatt attagaaaaa aacattttaa atttgtaaac gaatattttt 2940 ttaattttga aaactttatt tttttttaat gttgaatcaa cgtatcatac accaaacagt 3000 aaacagaaat tataataatg gaagaagtgc tttcttcgac aaatttccat tcaagccaca 3060 cagctacatg taagagaagt agaagtgatg tggtgtgatt ggctaggatg cagaagagct 3120 tcaggaatac aagaagtgag agcccaagga ttgggaggag ggggctctca catctccaca 3180 gtgcagtctg tcaaacccag cttggttttt atagtattct aagaattatt gtgtacaagg 3240 aaaagtctca catgtatgaa atccagtatc cagatggggt aaagttagca gataatagga 3300 taggaaatta aagacctaga tcttttttca cagacagaca caaattttta attcagggag 3360 aagggacaga ataaatgact tcccactcac aaagcacaac tcagaagtaa ttaaacaggt 3420 aacagaaacc ttgccatcaa acctttgata agatgtattt taagtagtaa gcagtatttc 3480 aatgcttctt acttaccctc ccaggacaac cgatctcaaa taagggagat aaggtagata 3540 aaaatcactt tttgattctg taataacata aacatagttc tttgggttag cacccccccc 3600 aaaaaaaatt tatgggagaa agaggactct cagctgactg aagaatacat ctcatttaaa 3660 tattttttag atgcctgaaa ctttaaaatt acctttaagt tttaatggta tttaccattt 3720 tgccaagacc tttgtgggga aacaagctta atgtttagtg attttgaaat ctctttcatg 3780 caggagagac agtgaaaatc tagccttggg tgtttaaggt tcgccttgtt actttgtaat 3840 agattttaat aagtttttct gctactttgc tgctatggtt tctccaatgg ctacatgatt 3900 tagttcatat gaagtatcat caacttagaa tctattcagc ttaaagatgt gtgttttgat 3960 gaactatctt accatttcac cataggctga ccacgtttct atagccaaaa atagctaaat 4020 acctcaatca gttccagaat gtcatttttt ggtactttgc tggccacaca agccgttatt 4080 caccgtttaa ctagttgtgt tctgcagtct atatttaact ttctttatgt ctgtggattt 4140 ttcccttcaa agttcaataa atttattttc ttggaaaa 4178

Claims (52)

  1. 그 길이가 18 내지 30개의 연결된 뉴클레오사이드인 변형된 올리고뉴클레오타이드를 포함하는 화합물이며, 여기서 상기 변형된 올리고뉴클레오타이드는 서열번호: 2의 핵염기 서열을 갖는 성장 호르몬 수용체 핵산의 핵염기 153921-153940의 동등 길이부에 대해 100% 상보적인 적어도 18개의 연속되는 핵염기의 부분을 포함하는 핵염기 서열을 갖고, 여기서 상기 변형된 올리고뉴클레오타이드의 핵염기 서열은 그의 전체 길이에 걸쳐 서열번호: 2에 대해 적어도 90% 상보적인 화합물.
  2. 제1항에 있어서, 상기 변형된 올리고뉴클레오타이드는 서열번호: 703에 나열된 서열을 포함하는 핵염기 서열을 갖는 것인 화합물.
  3. 제1항에 있어서, 상기 변형된 올리고뉴클레오타이드는 20개의 연결된 뉴클레오사이드로 이루어지고, 서열번호: 703에 나열된 서열로 이루어진 핵염기 서열을 갖는 것인 화합물.
  4. 제1항 내지 제3항 중 어느 한 항에 있어서, 상기 변형된 올리고뉴클레오타이드는 적어도 하나의 변형된 당을 포함하는 것인 화합물.
  5. 제4항에 있어서, 상기 적어도 하나의 변형된 당은 2'-O-메톡시에틸 기를 포함하거나 또는 바이사이클릭 당인 화합물.
  6. 제5항에 있어서, 상기 바이사이클릭 당이 4'-CH(CH3)-O-2' 기를 포함하거나, 또는 4'-CH2-O-2' 또는 4'-(CH2)2-O-2' 기를 포함하는 것인 화합물.
  7. 제1항 내지 제3항 중 어느 한 항에 있어서, 상기 변형된 올리고뉴클레오타이드는 적어도 하나의 변형된 뉴클레오사이드간 연결을 포함하는 것인 화합물.
  8. 제7항에 있어서, 상기 변형된 뉴클레오사이드간 연결은 포스포로티오에이트 뉴클레오사이드간 연결인 화합물.
  9. 제1항 내지 제3항 중 어느 한 항에 있어서, 상기 변형된 올리고뉴클레오타이드가 적어도 하나의 변형된 핵염기를 포함하는 것인 화합물.
  10. 제9항에 있어서, 상기 변형된 핵염기가 5-메틸시토신인 화합물.
  11. 제1항 내지 제3항 중 어느 한 항에 있어서, 상기 변형된 올리고뉴클레오타이드는
    연결된 데옥시뉴클레오사이드로 이루어진 갭 분절;
    연결된 뉴클레오사이드로 이루어진 5' 윙 분절; 및
    연결된 뉴클레오사이드로 이루어진 3' 윙 분절
    을 포함하고,
    여기서 상기 갭 분절은 5' 윙 분절과 3' 윙 분절 사이에 배치되고, 각각의 윙 분절의 각각의 뉴클레오사이드는 변형된 당을 포함하는 것인 화합물.
  12. 제1항 내지 제3항 중 어느 한 항에 있어서, 상기 변형된 올리고뉴클레오타이드는 서열번호: 703에 나열된 서열로 이루어진 핵염기 서열을 갖는 20개의 연결된 뉴클레오사이드로 이루어지고, 상기 변형된 올리고뉴클레오타이드는
    10개의 연결된 데옥시뉴클레오사이드로 이루어진 갭 분절;
    5개의 연결된 뉴클레오사이드로 이루어진 5' 윙 분절; 및
    5개의 연결된 뉴클레오사이드로 이루어진 3' 윙 분절
    을 포함하고,
    여기서 상기 갭 분절은 5' 윙 분절과 3' 윙 분절 사이에 배치되고; 각각의 윙 분절의 각각의 뉴클레오사이드는 2'-O-메톡시에틸 당을 포함하고; 적어도 하나의 뉴클레오사이드간 연결은 포스포로티오에이트 연결이고; 각각의 시토신은 5-메틸시토신인 화합물.
  13. 제1항 내지 제3항 중 어느 한 항에 있어서, 단일-가닥인 화합물.
  14. 제1항 내지 제3항 중 어느 한 항의 화합물을 포함하는, 인간에서 과잉의 성장 호르몬과 연관된 질환의 치료 또는 예방에 사용하기 위한 조성물.
  15. 제14항에 있어서, 상기 과잉의 성장 호르몬과 연관된 질환이 말단비대증인 조성물.
  16. 제15항에 있어서, 말단비대증을 치료하는 것이 IGF-1 수준을 감소시키는 것인 조성물.
  17. 제14항에 있어서, 인간에게 치료적으로 효과적인 양의 조성물을 투여하여 인간에서 성장 호르몬 수용체 (GHR) 수준을 감소시키는 것을 포함하는, 인간에서 GHR 수준을 감소시키는 데 사용하기 위한 조성물.
  18. 제17항에 있어서, 상기 인간이 과잉의 성장 호르몬과 연관된 질환을 가진 것인 조성물.
  19. 제18항에 있어서, 상기 질환이 말단비대증인 조성물.
  20. 제4항에 있어서, 상기 변형된 올리고뉴클레오타이드는 적어도 하나의 변형된 뉴클레오사이드간 연결을 포함하는 것인 화합물.
  21. 제5항에 있어서, 상기 변형된 올리고뉴클레오타이드는 적어도 하나의 변형된 뉴클레오사이드간 연결을 포함하는 것인 화합물.
  22. 제6항에 있어서, 상기 변형된 올리고뉴클레오타이드는 적어도 하나의 변형된 뉴클레오사이드간 연결을 포함하는 것인 화합물.
  23. 제4항에 있어서, 상기 변형된 올리고뉴클레오타이드가 적어도 하나의 변형된 핵염기를 포함하는 것인 화합물.
  24. 제5항에 있어서, 상기 변형된 올리고뉴클레오타이드가 적어도 하나의 변형된 핵염기를 포함하는 것인 화합물.
  25. 제6항에 있어서, 상기 변형된 올리고뉴클레오타이드가 적어도 하나의 변형된 핵염기를 포함하는 것인 화합물.
  26. 제7항에 있어서, 상기 변형된 올리고뉴클레오타이드가 적어도 하나의 변형된 핵염기를 포함하는 것인 화합물.
  27. 제8항에 있어서, 상기 변형된 올리고뉴클레오타이드가 적어도 하나의 변형된 핵염기를 포함하는 것인 화합물.
  28. 제5항에 있어서, 상기 변형된 올리고뉴클레오타이드는
    연결된 데옥시뉴클레오사이드로 이루어진 갭 분절;
    연결된 뉴클레오사이드로 이루어진 5' 윙 분절; 및
    연결된 뉴클레오사이드로 이루어진 3' 윙 분절
    을 포함하고,
    여기서 상기 갭 분절은 5' 윙 분절과 3' 윙 분절 사이에 배치되고, 각각의 윙 분절의 각각의 뉴클레오사이드는 변형된 당을 포함하는 것인 화합물.
  29. 제6항에 있어서, 상기 변형된 올리고뉴클레오타이드는
    연결된 데옥시뉴클레오사이드로 이루어진 갭 분절;
    연결된 뉴클레오사이드로 이루어진 5' 윙 분절; 및
    연결된 뉴클레오사이드로 이루어진 3' 윙 분절
    을 포함하고,
    여기서 상기 갭 분절은 5' 윙 분절과 3' 윙 분절 사이에 배치되고, 각각의 윙 분절의 각각의 뉴클레오사이드는 변형된 당을 포함하는 것인 화합물.
  30. 제7항에 있어서, 상기 변형된 올리고뉴클레오타이드는
    연결된 데옥시뉴클레오사이드로 이루어진 갭 분절;
    연결된 뉴클레오사이드로 이루어진 5' 윙 분절; 및
    연결된 뉴클레오사이드로 이루어진 3' 윙 분절
    을 포함하고,
    여기서 상기 갭 분절은 5' 윙 분절과 3' 윙 분절 사이에 배치되고, 각각의 윙 분절의 각각의 뉴클레오사이드는 변형된 당을 포함하는 것인 화합물.
  31. 제8항에 있어서, 상기 변형된 올리고뉴클레오타이드는
    연결된 데옥시뉴클레오사이드로 이루어진 갭 분절;
    연결된 뉴클레오사이드로 이루어진 5' 윙 분절; 및
    연결된 뉴클레오사이드로 이루어진 3' 윙 분절
    을 포함하고,
    여기서 상기 갭 분절은 5' 윙 분절과 3' 윙 분절 사이에 배치되고, 각각의 윙 분절의 각각의 뉴클레오사이드는 변형된 당을 포함하는 것인 화합물.
  32. 제9항에 있어서, 상기 변형된 올리고뉴클레오타이드는
    연결된 데옥시뉴클레오사이드로 이루어진 갭 분절;
    연결된 뉴클레오사이드로 이루어진 5' 윙 분절; 및
    연결된 뉴클레오사이드로 이루어진 3' 윙 분절
    을 포함하고,
    여기서 상기 갭 분절은 5' 윙 분절과 3' 윙 분절 사이에 배치되고, 각각의 윙 분절의 각각의 뉴클레오사이드는 변형된 당을 포함하는 것인 화합물.
  33. 제10항에 있어서, 상기 변형된 올리고뉴클레오타이드는
    연결된 데옥시뉴클레오사이드로 이루어진 갭 분절;
    연결된 뉴클레오사이드로 이루어진 5' 윙 분절; 및
    연결된 뉴클레오사이드로 이루어진 3' 윙 분절
    을 포함하고,
    여기서 상기 갭 분절은 5' 윙 분절과 3' 윙 분절 사이에 배치되고, 각각의 윙 분절의 각각의 뉴클레오사이드는 변형된 당을 포함하는 것인 화합물.
  34. 제6항에 있어서, 상기 변형된 올리고뉴클레오타이드는 서열번호: 703에 나열된 서열로 이루어진 핵염기 서열을 갖는 20개의 연결된 뉴클레오사이드로 이루어지고, 상기 변형된 올리고뉴클레오타이드는
    10개의 연결된 데옥시뉴클레오사이드로 이루어진 갭 분절;
    5개의 연결된 뉴클레오사이드로 이루어진 5' 윙 분절; 및
    5개의 연결된 뉴클레오사이드로 이루어진 3' 윙 분절
    을 포함하고,
    여기서 상기 갭 분절은 5' 윙 분절과 3' 윙 분절 사이에 배치되고; 각각의 윙 분절의 각각의 뉴클레오사이드는 2'-O-메톡시에틸 당을 포함하고; 적어도 하나의 뉴클레오사이드간 연결은 포스포로티오에이트 연결이고; 각각의 시토신은 5-메틸시토신인 화합물.
  35. 제4항에 있어서, 단일-가닥인 화합물.
  36. 제5항에 있어서, 단일-가닥인 화합물.
  37. 제6항에 있어서, 단일-가닥인 화합물.
  38. 제7항에 있어서, 단일-가닥인 화합물.
  39. 제8항에 있어서, 단일-가닥인 화합물.
  40. 제9항에 있어서, 단일-가닥인 화합물.
  41. 제10항에 있어서, 단일-가닥인 화합물.
  42. 제11항에 있어서, 단일-가닥인 화합물.
  43. 제12항에 있어서, 단일-가닥인 화합물.
  44. 삭제
  45. 삭제
  46. 삭제
  47. 삭제
  48. 삭제
  49. 삭제
  50. 삭제
  51. 삭제
  52. 삭제
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