DE60120194T2 - Pyrazolverbindungen als protein-kinasehemmer - Google Patents

Pyrazolverbindungen als protein-kinasehemmer Download PDF

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Publication number
DE60120194T2
DE60120194T2 DE60120194T DE60120194T DE60120194T2 DE 60120194 T2 DE60120194 T2 DE 60120194T2 DE 60120194 T DE60120194 T DE 60120194T DE 60120194 T DE60120194 T DE 60120194T DE 60120194 T2 DE60120194 T2 DE 60120194T2
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ring
optionally substituted
aliphatic
con
phenyl
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Expired - Lifetime
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DE60120194T
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English (en)
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DE60120194D1 (de
Inventor
Julian M.C. Ashbury GOLEC
Vertex Pharmaceuticals Inc. Jean-Damien Southam Bishops Itchington CHARRIER
Ronald Abingdom KNEGTEL
David Newbury BEBBINGTON
Robert Arlington DAVIES
Pan Arlington LI
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
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  • Diabetes (AREA)
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  • Rheumatology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
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  • Psychiatry (AREA)
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DE60120194T 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer Expired - Lifetime DE60120194T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US23279500P 2000-09-15 2000-09-15
US232795P 2000-09-15
US25788700P 2000-12-21 2000-12-21
US257887P 2000-12-21
US28694901P 2001-04-27 2001-04-27
US286949P 2001-04-27
PCT/US2001/028793 WO2002022605A1 (en) 2000-09-15 2001-09-14 Pyrazole compounds useful as protein kinase inhibitors

Publications (2)

Publication Number Publication Date
DE60120194D1 DE60120194D1 (de) 2006-07-06
DE60120194T2 true DE60120194T2 (de) 2007-03-29

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ID=27398347

Family Applications (8)

Application Number Title Priority Date Filing Date
DE60120194T Expired - Lifetime DE60120194T2 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
DE60119748T Expired - Lifetime DE60119748T2 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
DE60124744T Expired - Lifetime DE60124744T2 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
DE60119749T Expired - Lifetime DE60119749T2 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
DE60120193T Expired - Lifetime DE60120193T2 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
DE60120198T Expired - Lifetime DE60120198T2 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
DE60128709T Expired - Lifetime DE60128709T2 (de) 2000-09-15 2001-09-14 Triazol-verbindungen als protein-kinase-inhibitoren
DE60110616T Expired - Lifetime DE60110616T3 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer

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DE60119748T Expired - Lifetime DE60119748T2 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
DE60124744T Expired - Lifetime DE60124744T2 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
DE60119749T Expired - Lifetime DE60119749T2 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
DE60120193T Expired - Lifetime DE60120193T2 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
DE60120198T Expired - Lifetime DE60120198T2 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
DE60128709T Expired - Lifetime DE60128709T2 (de) 2000-09-15 2001-09-14 Triazol-verbindungen als protein-kinase-inhibitoren
DE60110616T Expired - Lifetime DE60110616T3 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer

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US (7) US6638926B2 (enExample)
EP (8) EP1318814B1 (enExample)
JP (9) JP4105948B2 (enExample)
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CN (3) CN1469875A (enExample)
AP (1) AP2003002762A0 (enExample)
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AU (9) AU2001296871A1 (enExample)
BR (1) BR0114088A (enExample)
CA (8) CA2422371C (enExample)
DE (8) DE60120194T2 (enExample)
DK (1) DK1318997T3 (enExample)
ES (3) ES2266258T3 (enExample)
HU (4) HUP0302411A2 (enExample)
IL (6) IL154747A0 (enExample)
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NO (4) NO20031188L (enExample)
NZ (4) NZ525009A (enExample)
PE (1) PE20020451A1 (enExample)
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PT (2) PT1318997E (enExample)
TW (1) TWI303636B (enExample)
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