CN1861077A - 作为治疗或预防糖尿病的二肽基肽酶抑制剂的β－氨基四氢咪唑并(1,2－A)吡嗪和四氢三唑并(4,3－A)吡嗪 - Google Patents

作为治疗或预防糖尿病的二肽基肽酶抑制剂的β－氨基四氢咪唑并(1,2－A)吡嗪和四氢三唑并(4,3－A)吡嗪 Download PDF

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Publication number
CN1861077A
CN1861077A CNA2006100776910A CN200610077691A CN1861077A CN 1861077 A CN1861077 A CN 1861077A CN A2006100776910 A CNA2006100776910 A CN A2006100776910A CN 200610077691 A CN200610077691 A CN 200610077691A CN 1861077 A CN1861077 A CN 1861077A
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Prior art keywords
acid
chemical compound
pyrazine
amino
base
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Pending
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CNA2006100776910A
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Chinese (zh)
Inventor
S·D·埃蒙森
M·H·费舍尔
D·金
M·麦科斯
E·R·帕梅
A·E·韦伯
徐锦优
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Merck and Co Inc
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Merck and Co Inc
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Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of CN1861077A publication Critical patent/CN1861077A/zh
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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CNA2006100776910A 2001-07-06 2002-07-05 作为治疗或预防糖尿病的二肽基肽酶抑制剂的β－氨基四氢咪唑并(1,2－A)吡嗪和四氢三唑并(4,3－A)吡嗪 Pending CN1861077A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30347401P 2001-07-06 2001-07-06
US60/303474 2001-07-06

Related Parent Applications (1)

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CNB02813558XA Division CN1290848C (zh) 2001-07-06 2002-07-05 作为治疗或预防糖尿病的二肽基肽酶抑制剂的β－氨基四氢咪唑并(1,2－A)吡嗪和四氢三唑并(4,3－A)吡嗪

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CN1861077A true CN1861077A (zh) 2006-11-15

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CNA2006100776910A Pending CN1861077A (zh) 2001-07-06 2002-07-05 作为治疗或预防糖尿病的二肽基肽酶抑制剂的β－氨基四氢咪唑并(1,2－A)吡嗪和四氢三唑并(4,3－A)吡嗪
CNB02813558XA Expired - Lifetime CN1290848C (zh) 2001-07-06 2002-07-05 作为治疗或预防糖尿病的二肽基肽酶抑制剂的β－氨基四氢咪唑并(1,2－A)吡嗪和四氢三唑并(4,3－A)吡嗪

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US (9) US7125873B2 (enrdf_load_stackoverflow)
EP (4) EP2226324A1 (enrdf_load_stackoverflow)
JP (1) JP3762407B2 (enrdf_load_stackoverflow)
KR (1) KR100606871B1 (enrdf_load_stackoverflow)
CN (2) CN1861077A (enrdf_load_stackoverflow)
AR (1) AR036114A1 (enrdf_load_stackoverflow)
AT (2) ATE471148T1 (enrdf_load_stackoverflow)
AU (1) AU2002320303B2 (enrdf_load_stackoverflow)
BE (1) BE2007C047I2 (enrdf_load_stackoverflow)
BG (1) BG108493A (enrdf_load_stackoverflow)
BR (1) BRPI0210866B8 (enrdf_load_stackoverflow)
CA (1) CA2450740C (enrdf_load_stackoverflow)
CR (1) CR7235A (enrdf_load_stackoverflow)
CY (3) CY2007019I2 (enrdf_load_stackoverflow)
DE (4) DE122008000046I1 (enrdf_load_stackoverflow)
DK (2) DK1412357T3 (enrdf_load_stackoverflow)
DO (1) DOP2002000438A (enrdf_load_stackoverflow)
EA (2) EA012701B1 (enrdf_load_stackoverflow)
EC (1) ECSP044935A (enrdf_load_stackoverflow)
ES (2) ES2344846T3 (enrdf_load_stackoverflow)
FR (2) FR07C0041I2 (enrdf_load_stackoverflow)
GE (2) GEP20053734B (enrdf_load_stackoverflow)
HR (1) HRP20031098B1 (enrdf_load_stackoverflow)
HU (2) HU225695B1 (enrdf_load_stackoverflow)
IL (3) IL159109A0 (enrdf_load_stackoverflow)
IS (2) IS2218B (enrdf_load_stackoverflow)
JO (1) JO2230B1 (enrdf_load_stackoverflow)
LT (1) LTC1412357I2 (enrdf_load_stackoverflow)
LU (2) LUC91360I2 (enrdf_load_stackoverflow)
MA (1) MA27053A1 (enrdf_load_stackoverflow)
ME (1) ME00439B (enrdf_load_stackoverflow)
MX (1) MXPA04000018A (enrdf_load_stackoverflow)
MY (1) MY127961A (enrdf_load_stackoverflow)
NL (2) NL300287I2 (enrdf_load_stackoverflow)
NO (4) NO321999B1 (enrdf_load_stackoverflow)
NZ (1) NZ529833A (enrdf_load_stackoverflow)
PE (1) PE20030654A1 (enrdf_load_stackoverflow)
PL (1) PL196278B6 (enrdf_load_stackoverflow)
PT (2) PT1625847E (enrdf_load_stackoverflow)
RS (1) RS50737B (enrdf_load_stackoverflow)
SI (1) SI1412357T1 (enrdf_load_stackoverflow)
TW (1) TWI226331B (enrdf_load_stackoverflow)
UA (1) UA74912C2 (enrdf_load_stackoverflow)
WO (1) WO2003004498A1 (enrdf_load_stackoverflow)
ZA (1) ZA200309294B (enrdf_load_stackoverflow)

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CN102271504A (zh) * 2008-12-31 2011-12-07 凯瑞斯德股份有限公司 用于制备N-酰化-4-芳基β-氨基酸衍生物的方法和中间体
CN102603749A (zh) * 2011-10-27 2012-07-25 浙江华海药业股份有限公司 一种西他列汀中间体的合成方法
CN102946726A (zh) * 2010-04-05 2013-02-27 卡帝拉药物有限公司 新型降血糖化合物
CN103403008A (zh) * 2011-01-20 2013-11-20 St制药株式会社 西他列汀中间体的制备方法
CN103476778A (zh) * 2011-03-03 2013-12-25 卡迪拉保健有限公司 Dpp-iv抑制剂的新的盐
CN103597071A (zh) * 2011-01-07 2014-02-19 埃尔舍利克斯治疗公司 基于化学感应受体配体的治疗
CN103626775A (zh) * 2013-12-02 2014-03-12 南京华威医药科技开发有限公司 具有二嗪结构的dpp-4抑制剂
CN105669682A (zh) * 2013-02-22 2016-06-15 成都先导药物开发有限公司 一种dpp-iv抑制剂的中间体
US10603291B2 (en) 2012-01-06 2020-03-31 Anji Pharma (Us) Llc Compositions and methods for treating metabolic disorders
US10668031B2 (en) 2011-01-07 2020-06-02 Anji Pharma (Us) Llc Biguanide compositions and methods of treating metabolic disorders
US11065215B2 (en) 2011-01-07 2021-07-20 Anji Pharma (Us) Llc Biguanide compositions and methods of treating metabolic disorders
US11759441B2 (en) 2011-01-07 2023-09-19 Anji Pharmaceuticals Inc. Biguanide compositions and methods of treating metabolic disorders
US11974971B2 (en) 2011-01-07 2024-05-07 Anji Pharmaceuticals Inc. Compositions and methods for treating metabolic disorders

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US7544511B2 (en) * 1996-09-25 2009-06-09 Neuralstem Biopharmaceuticals Ltd. Stable neural stem cell line methods
US20030176357A1 (en) * 1998-10-06 2003-09-18 Pospisilik Andrew J. Dipeptidyl peptidase IV inhibitors and their uses for lowering blood pressure levels
ATE440100T1 (de) * 1998-12-31 2009-09-15 Ipsen Pharma Prenyl transferasinhibitoren
AU2002310465B2 (en) 2001-06-20 2006-06-15 Merck & Co., Inc. Dipeptidyl peptidase inhibitors for the treatment of diabetes
AU2002344820B2 (en) 2001-06-20 2006-12-14 Merck & Co., Inc. Dipeptidyl peptidase inhibitors for the treatment of diabetes
MXPA03011907A (es) 2001-06-27 2004-03-26 Smithkline Beecham Corp Fluoropirrolidinas como inhibidores de dipeptidil peptidasa.
UA74912C2 (en) * 2001-07-06 2006-02-15 Merck & Co Inc Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes
JP2006514914A (ja) * 2002-02-14 2006-05-18 バイエル・フアーマシユーチカルズ・コーポレーシヨン 有機溶媒中および乾燥状態のペプチドの安定化における製剤の戦略
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US7105526B2 (en) 2002-06-28 2006-09-12 Banyu Pharmaceuticals Co., Ltd. Benzimidazole derivatives
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