ES2421956B1 - Nueva forma cristalina de sulfato de sitagliptina - Google Patents
Nueva forma cristalina de sulfato de sitagliptina Download PDFInfo
- Publication number
- ES2421956B1 ES2421956B1 ES201230319A ES201230319A ES2421956B1 ES 2421956 B1 ES2421956 B1 ES 2421956B1 ES 201230319 A ES201230319 A ES 201230319A ES 201230319 A ES201230319 A ES 201230319A ES 2421956 B1 ES2421956 B1 ES 2421956B1
- Authority
- ES
- Spain
- Prior art keywords
- sulfate
- sitagliptina
- crystal form
- new crystal
- crystalline form
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
Abstract
Nueva forma cristalina de sulfato de sitagliptina.#La presente invención está dirigida a una nueva forma cristalina del sulfato de sitagliptina, a un procedimiento para su obtención, a composiciones farmacéuticas que comprenden la nueva forma cristalina y al uso de dicha forma cristalina para la fabricación de un medicamento.
Description
Claims (1)
-
imagen1 imagen2
Priority Applications (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES201230319A ES2421956B1 (es) | 2012-03-02 | 2012-03-02 | Nueva forma cristalina de sulfato de sitagliptina |
ES13706567.8T ES2628920T3 (es) | 2012-03-02 | 2013-03-01 | Forma cristalina novedosa de sulfato de sitagliptina |
NZ629511A NZ629511A (en) | 2012-03-02 | 2013-03-01 | Novel crystalline form of sitagliptin sulfate |
PT137065678T PT2820019T (pt) | 2012-03-02 | 2013-03-01 | Nova forma cristalina de sulfato de sitagliptina |
EP13706567.8A EP2820019B1 (en) | 2012-03-02 | 2013-03-01 | Novel crystalline form of sitagliptin sulfate |
AU2013224897A AU2013224897A1 (en) | 2012-03-02 | 2013-03-01 | Novel crystalline form of sitagliptin sulfate |
PL13706567T PL2820019T3 (pl) | 2012-03-02 | 2013-03-01 | Nowa krystaliczna forma siarczanu sitagliptyny |
US14/381,954 US9181260B2 (en) | 2012-03-02 | 2013-03-01 | Crystalline form of sitagliptin sulfate |
HUE13706567A HUE033496T2 (en) | 2012-03-02 | 2013-03-01 | New sitagliptin sulfate crystal form |
PCT/EP2013/054164 WO2013128000A1 (en) | 2012-03-02 | 2013-03-01 | Novel crystalline form of sitagliptin sulfate |
DK13706567.8T DK2820019T3 (en) | 2012-03-02 | 2013-03-01 | Hitherto crystalline form of sitagliptin sulfate |
MX2014010433A MX2014010433A (es) | 2012-03-02 | 2013-03-01 | Nueva forma cristalina de sulfato de sitagliptina. |
SI201330671A SI2820019T1 (sl) | 2012-03-02 | 2013-03-01 | Nova kristalna oblika sitagliptin sulfata |
IL234401A IL234401A (en) | 2012-03-02 | 2014-08-31 | Crystalline structures of sitglyphatin sulfate |
ZA2014/06431A ZA201406431B (en) | 2012-03-02 | 2014-09-02 | Novel crystalline form of sitagliptin sulfate |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES201230319A ES2421956B1 (es) | 2012-03-02 | 2012-03-02 | Nueva forma cristalina de sulfato de sitagliptina |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2421956A1 ES2421956A1 (es) | 2013-09-06 |
ES2421956B1 true ES2421956B1 (es) | 2014-09-29 |
Family
ID=47754555
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES201230319A Expired - Fee Related ES2421956B1 (es) | 2012-03-02 | 2012-03-02 | Nueva forma cristalina de sulfato de sitagliptina |
ES13706567.8T Active ES2628920T3 (es) | 2012-03-02 | 2013-03-01 | Forma cristalina novedosa de sulfato de sitagliptina |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES13706567.8T Active ES2628920T3 (es) | 2012-03-02 | 2013-03-01 | Forma cristalina novedosa de sulfato de sitagliptina |
Country Status (14)
Country | Link |
---|---|
US (1) | US9181260B2 (es) |
EP (1) | EP2820019B1 (es) |
AU (1) | AU2013224897A1 (es) |
DK (1) | DK2820019T3 (es) |
ES (2) | ES2421956B1 (es) |
HU (1) | HUE033496T2 (es) |
IL (1) | IL234401A (es) |
MX (1) | MX2014010433A (es) |
NZ (1) | NZ629511A (es) |
PL (1) | PL2820019T3 (es) |
PT (1) | PT2820019T (es) |
SI (1) | SI2820019T1 (es) |
WO (1) | WO2013128000A1 (es) |
ZA (1) | ZA201406431B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9171343B1 (en) | 2012-09-11 | 2015-10-27 | Aseko, Inc. | Means and method for improved glycemic control for diabetic patients |
US9897565B1 (en) | 2012-09-11 | 2018-02-20 | Aseko, Inc. | System and method for optimizing insulin dosages for diabetic subjects |
US9486580B2 (en) | 2014-01-31 | 2016-11-08 | Aseko, Inc. | Insulin management |
US9233204B2 (en) | 2014-01-31 | 2016-01-12 | Aseko, Inc. | Insulin management |
PL3102187T3 (pl) | 2014-02-03 | 2020-10-19 | Galenicum Health S.L. | Stabilne kompozycje farmaceutyczne zawierające sitagliptynę w postaci tabletek o natychmiastowym uwalnianiu |
WO2016034710A1 (en) * | 2014-09-05 | 2016-03-10 | Sanovel Ilac Sanayi Ve Ticaret A.S. | Pharmaceutical combinations of sitagliptin |
US11081226B2 (en) | 2014-10-27 | 2021-08-03 | Aseko, Inc. | Method and controller for administering recommended insulin dosages to a patient |
EP3050023B1 (en) | 2014-10-27 | 2021-08-25 | Aseko, Inc. | Subcutaneous outpatient management |
CA2993275C (en) | 2015-08-20 | 2022-06-21 | Aseko, Inc. | Diabetes management therapy advisor |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA74912C2 (en) | 2001-07-06 | 2006-02-15 | Merck & Co Inc | Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes |
AR043515A1 (es) | 2003-03-19 | 2005-08-03 | Merck & Co Inc | Procedimiento para preparar derivados quirales beta aminoacidos mediante hidrogenacion asimetrica |
JO2625B1 (en) | 2003-06-24 | 2011-11-01 | ميرك شارب اند دوم كوربوريشن | Phosphoric acid salts of dipeptidyl betidase inhibitor 4 |
US20080227786A1 (en) | 2004-01-16 | 2008-09-18 | Ferlita Russell R | Novel Crystalline Salts of a Dipeptidyl Peptidase-IV Inhibitor |
BR122018073405B1 (pt) | 2004-01-20 | 2023-04-25 | Novartis Ag | Comprimido farmacêutico produzido por compressão direta compreendendo inibidor de dipeptidilpeptidase iv |
US20090221592A1 (en) | 2005-07-25 | 2009-09-03 | Ellison Martha E | Dodecylsulfate Salt Of A Dipeptidyl Peptidase-Iv Inhibitor |
WO2009064476A1 (en) | 2007-11-13 | 2009-05-22 | Teva Pharmaceutical Industries Ltd. | Preparation of sitagliptin intermediate |
JP2011507890A (ja) * | 2007-12-20 | 2011-03-10 | ドクター・レディーズ・ラボラトリーズ・リミテッド | シタグリプチンおよびその薬学的に許容可能な塩の調製のためのプロセス |
EP2650299A1 (en) * | 2008-07-03 | 2013-10-16 | Ratiopharm GmbH | Crystalline salts of sitagliptin |
EP2218721A1 (en) | 2009-02-11 | 2010-08-18 | LEK Pharmaceuticals d.d. | Novel salts of sitagliptin |
WO2010117738A2 (en) * | 2009-03-30 | 2010-10-14 | Teva Pharmaceutical Industries Ltd. | Solid state forms of sitagliptin salts |
US8183373B2 (en) * | 2010-03-31 | 2012-05-22 | Teva Pharmaceutical Industries Ltd. | Solid state forms of sitagliptin salts |
-
2012
- 2012-03-02 ES ES201230319A patent/ES2421956B1/es not_active Expired - Fee Related
-
2013
- 2013-03-01 AU AU2013224897A patent/AU2013224897A1/en not_active Abandoned
- 2013-03-01 US US14/381,954 patent/US9181260B2/en not_active Expired - Fee Related
- 2013-03-01 PT PT137065678T patent/PT2820019T/pt unknown
- 2013-03-01 MX MX2014010433A patent/MX2014010433A/es unknown
- 2013-03-01 ES ES13706567.8T patent/ES2628920T3/es active Active
- 2013-03-01 HU HUE13706567A patent/HUE033496T2/en unknown
- 2013-03-01 PL PL13706567T patent/PL2820019T3/pl unknown
- 2013-03-01 SI SI201330671A patent/SI2820019T1/sl unknown
- 2013-03-01 NZ NZ629511A patent/NZ629511A/en not_active IP Right Cessation
- 2013-03-01 EP EP13706567.8A patent/EP2820019B1/en active Active
- 2013-03-01 DK DK13706567.8T patent/DK2820019T3/en active
- 2013-03-01 WO PCT/EP2013/054164 patent/WO2013128000A1/en active Application Filing
-
2014
- 2014-08-31 IL IL234401A patent/IL234401A/en not_active IP Right Cessation
- 2014-09-02 ZA ZA2014/06431A patent/ZA201406431B/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP2820019A1 (en) | 2015-01-07 |
DK2820019T3 (en) | 2017-07-03 |
ES2421956A1 (es) | 2013-09-06 |
ZA201406431B (en) | 2016-05-25 |
NZ629511A (en) | 2016-04-29 |
AU2013224897A1 (en) | 2014-09-18 |
HUE033496T2 (en) | 2017-12-28 |
PL2820019T3 (pl) | 2017-09-29 |
US9181260B2 (en) | 2015-11-10 |
IL234401A (en) | 2017-11-30 |
MX2014010433A (es) | 2015-04-13 |
ES2628920T3 (es) | 2017-08-04 |
SI2820019T1 (sl) | 2017-07-31 |
WO2013128000A1 (en) | 2013-09-06 |
EP2820019B1 (en) | 2017-03-22 |
PT2820019T (pt) | 2017-06-26 |
US20150037406A1 (en) | 2015-02-05 |
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