ATE440100T1 - Prenyl transferasinhibitoren - Google Patents

Prenyl transferasinhibitoren

Info

Publication number
ATE440100T1
ATE440100T1 AT03078315T AT03078315T ATE440100T1 AT E440100 T1 ATE440100 T1 AT E440100T1 AT 03078315 T AT03078315 T AT 03078315T AT 03078315 T AT03078315 T AT 03078315T AT E440100 T1 ATE440100 T1 AT E440100T1
Authority
AT
Austria
Prior art keywords
prenyl
transferas
inhibitors
chem
bond
Prior art date
Application number
AT03078315T
Other languages
English (en)
Inventor
Thomas Gordon
Barry A Morgan
Original Assignee
Ipsen Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ipsen Pharma filed Critical Ipsen Pharma
Application granted granted Critical
Publication of ATE440100T1 publication Critical patent/ATE440100T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT03078315T 1998-12-31 1999-12-30 Prenyl transferasinhibitoren ATE440100T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22442898A 1998-12-31 1998-12-31
US11430198P 1998-12-31 1998-12-31

Publications (1)

Publication Number Publication Date
ATE440100T1 true ATE440100T1 (de) 2009-09-15

Family

ID=26812031

Family Applications (2)

Application Number Title Priority Date Filing Date
AT03078315T ATE440100T1 (de) 1998-12-31 1999-12-30 Prenyl transferasinhibitoren
AT99968984T ATE261447T1 (de) 1998-12-31 1999-12-30 Prenyltransferase-inhibitoren

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT99968984T ATE261447T1 (de) 1998-12-31 1999-12-30 Prenyltransferase-inhibitoren

Country Status (14)

Country Link
US (2) US7361656B2 (de)
EP (2) EP1140942B1 (de)
AT (2) ATE440100T1 (de)
AU (1) AU2717100A (de)
CA (1) CA2356756A1 (de)
CZ (1) CZ20012358A3 (de)
DE (2) DE69915514T2 (de)
DK (1) DK1140942T3 (de)
ES (2) ES2215420T3 (de)
HU (1) HUP0104708A3 (de)
NO (1) NO321057B1 (de)
PT (1) PT1140942E (de)
RU (1) RU2241712C9 (de)
WO (1) WO2000039130A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2812546B1 (fr) * 2000-08-01 2008-11-21 Sod Conseils Rech Applic Derives d'heterocycles a 5 chainons, leur preparation et leur application a titre de medicaments
TWI283577B (en) * 1999-10-11 2007-07-11 Sod Conseils Rech Applic Pharmaceutical composition of imidazole derivatives acting as modulators of sodium channels and the use thereof
EP1542691B1 (de) * 2002-09-27 2009-01-07 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Zubereitung zur behandlung des nasopharyngalen carcinom und verwendung derselben
US8410155B2 (en) * 2006-12-15 2013-04-02 Bristol-Myers Squibb Company Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor XIA inhibitors
JO3156B1 (ar) * 2009-07-09 2017-09-20 Novartis Ag ايميدازولات مدمجة والتركيبات التي تشملها لعلاج الأمراض الطفيلية على مثال الملاريا
EP2508511A1 (de) 2011-04-07 2012-10-10 Laboratoire Biodim Inhibitoren der Virenreplikation, Verfahren zu deren Herstellung und deren therapeutische Verwendung
KR102196374B1 (ko) * 2012-11-29 2020-12-31 케모센트릭스, 인크. Cxcr7 길항제
CN106317057B (zh) * 2015-07-02 2019-02-01 北京桦冠医药科技有限公司 具有咪唑并吡嗪类衍生物，其制备及其在医药上的应用
MX2019012758A (es) 2017-04-24 2019-12-16 Novartis Ag Regimen terapeutico de 2-amino-1-(2-(4-fluorofenil)-3-(4-fluorofen ilamino)-8,8-dimetil-5,6-dihidroimidazo [1,2-a]pirazin-7(8h)-il)et anona y combinaciones de la misma.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2760364B2 (ja) * 1989-02-27 1998-05-28 バイオクライシス・ファーマシューティカルズ、インコーポレイテッド ９―置換―８―非置換―９―デアザグアニン類
RU2092487C1 (ru) * 1992-04-24 1997-10-10 Ньюроджен Корпорейшн Имидазохиноксалины
EP0698015A1 (de) * 1993-05-14 1996-02-28 Genentech, Inc. Inhibitoren der farnesyl protein-transferase
US5488109A (en) * 1993-11-05 1996-01-30 Dowelanco 5-alkoxy[1,2,4]triazolo[1,5-c]pyrimidine-2(3H)--thione compounds and their use in the preparation of and 2-chlorosulfonyl-5-alkoxy[1,2,4]triazolo[1,5-c]-pyrimidine compounds
US5488189A (en) * 1993-12-14 1996-01-30 E. I. Du Pont De Nemours And Company Process for fluorinated propanes and pentanes
US6673927B2 (en) * 1996-02-16 2004-01-06 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Farnesyl transferase inhibitors
FR2780974B1 (fr) * 1998-07-08 2001-09-28 Sod Conseils Rech Applic Utilisation de derives d'imidazopyrazines pour preparer un medicament destine a traiter les pathologies qui resultent de la formation de la proteine g heterotrimetrique
UA74912C2 (en) * 2001-07-06 2006-02-15 Merck & Co Inc Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes

Also Published As

Publication number Publication date
DE69915514D1 (de) 2004-04-15
EP1140942A2 (de) 2001-10-10
EP1382607B1 (de) 2009-08-19
US20060142275A1 (en) 2006-06-29
ES2328564T3 (es) 2009-11-16
WO2000039130A3 (en) 2000-11-02
ATE261447T1 (de) 2004-03-15
CZ20012358A3 (cs) 2002-01-16
EP1382607A2 (de) 2004-01-21
RU2241712C9 (ru) 2006-04-20
HUP0104708A3 (en) 2004-05-28
EP1140942B1 (de) 2004-03-10
EP1382607A3 (de) 2004-06-30
US7361656B2 (en) 2008-04-22
DE69915514T2 (de) 2005-01-05
DK1140942T3 (da) 2004-05-24
US20080176835A1 (en) 2008-07-24
ES2215420T3 (es) 2004-10-01
AU2717100A (en) 2000-07-31
RU2241712C2 (ru) 2004-12-10
PT1140942E (pt) 2004-05-31
NO321057B1 (no) 2006-03-06
WO2000039130A2 (en) 2000-07-06
NO20013281L (no) 2001-08-29
US7691859B2 (en) 2010-04-06
HUP0104708A2 (hu) 2002-04-29
CA2356756A1 (en) 2000-07-06
DE69941307D1 (de) 2009-10-01
NO20013281D0 (no) 2001-06-29

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties