CN105384825B - 一种基于单域抗体的双特异性嵌合抗原受体及其应用 - Google Patents

一种基于单域抗体的双特异性嵌合抗原受体及其应用 Download PDF

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CN105384825B
CN105384825B CN201510733585.2A CN201510733585A CN105384825B CN 105384825 B CN105384825 B CN 105384825B CN 201510733585 A CN201510733585 A CN 201510733585A CN 105384825 B CN105384825 B CN 105384825B
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cells
car
chimeric antigen
antigen receptor
domain antibody
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Chinese (zh)
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CN105384825A (zh
Inventor
范晓虎
周传初
庄秋传
王平艳
王林
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Nanjing Legend Biotechnology Co Ltd
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Nanjing Legend Biotechnology Co Ltd
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Priority to CN201510733585.2A priority Critical patent/CN105384825B/zh
Publication of CN105384825A publication Critical patent/CN105384825A/zh
Priority to EP24174651.0A priority patent/EP4424376A3/en
Priority to BR112018002844-4A priority patent/BR112018002844A2/pt
Priority to PCT/CN2016/094408 priority patent/WO2017025038A1/en
Priority to EP16834662.5A priority patent/EP3334765A4/en
Priority to SI201631840T priority patent/SI4063397T1/sl
Priority to LTEP22168161.2T priority patent/LT4063397T/lt
Priority to EA201890302A priority patent/EA201890302A1/ru
Priority to SM20240311T priority patent/SMT202400311T1/it
Priority to RS20240831A priority patent/RS65866B1/sr
Priority to SG10201913485QA priority patent/SG10201913485QA/en
Priority to ES22168161T priority patent/ES2984851T3/es
Priority to CR20210225A priority patent/CR20210225A/es
Priority to IL294683A priority patent/IL294683A/en
Priority to PL22168161.2T priority patent/PL4063397T3/pl
Priority to MX2018001739A priority patent/MX2018001739A/es
Priority to KR1020247039135A priority patent/KR20240173368A/ko
Priority to JP2018526984A priority patent/JP6859347B2/ja
Priority to CR20180153A priority patent/CR20180153A/es
Priority to UAA201802367A priority patent/UA125818C2/uk
Priority to NZ758571A priority patent/NZ758571A/en
Priority to US15/751,609 priority patent/US10934363B2/en
Priority to EP22168161.2A priority patent/EP4063397B1/en
Priority to AU2016305075A priority patent/AU2016305075B2/en
Priority to PH1/2018/500295A priority patent/PH12018500295B1/en
Priority to FIEP22168161.2T priority patent/FI4063397T3/fi
Priority to DK22168161.2T priority patent/DK4063397T3/da
Priority to HUE22168161A priority patent/HUE067869T2/hu
Priority to PT221681612T priority patent/PT4063397T/pt
Priority to IL257297A priority patent/IL257297B/en
Priority to CA2994579A priority patent/CA2994579C/en
Priority to NZ778787A priority patent/NZ778787B2/en
Priority to KR1020187006996A priority patent/KR20180035918A/ko
Priority to MYPI2018000199A priority patent/MY188362A/en
Priority to ZA2018/00703A priority patent/ZA201800703B/en
Priority to MX2022015823A priority patent/MX2022015823A/es
Priority to CL2018000378A priority patent/CL2018000378A1/es
Priority to SA518390904A priority patent/SA518390904B1/ar
Priority to CONC2018/0001405A priority patent/CO2018001405A2/es
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Publication of CN105384825B publication Critical patent/CN105384825B/zh
Priority to AU2020200151A priority patent/AU2020200151C1/en
Priority to US17/164,125 priority patent/US20210261675A1/en
Priority to JP2021052453A priority patent/JP7168173B2/ja
Priority to CL2021001686A priority patent/CL2021001686A1/es
Priority to AU2022204180A priority patent/AU2022204180A1/en
Priority to JP2022167222A priority patent/JP2022183283A/ja
Priority to JP2024014929A priority patent/JP2024032975A/ja
Priority to NL301301C priority patent/NL301301I2/nl
Priority to LTPA2024535C priority patent/LTPA2024535I1/lt
Priority to FR24C1050C priority patent/FR24C1050I2/fr
Priority to FIC20240042C priority patent/FIC20240042I1/fi
Priority to JP2025134318A priority patent/JP2025159117A/ja
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CN201510733585.2A CN105384825B (zh) 2015-08-11 2015-11-02 一种基于单域抗体的双特异性嵌合抗原受体及其应用
EP24174651.0A EP4424376A3 (en) 2015-08-11 2016-08-10 Chimeric antigen receptors based on single-domain antibodies and methods of use thereof
BR112018002844-4A BR112018002844A2 (pt) 2015-08-11 2016-08-10 receptores de antígeno quimérico à base de anticorpos de domínio único e métodos de uso dos mesmos
PCT/CN2016/094408 WO2017025038A1 (en) 2015-08-11 2016-08-10 Chimeric antigen receptors based on single-domain antibodies and methods of use thereof
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SI201631840T SI4063397T1 (sl) 2015-08-11 2016-08-10 Himerni antigenski receptorji na osnovi enodomenskih protiteles in načini za njihovo uporabo
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SM20240311T SMT202400311T1 (it) 2015-08-11 2016-08-10 Recettori antigeni chimerici basati su anticorpi a dominio singolo e relativi metodi di utilizzo
RS20240831A RS65866B1 (sr) 2015-08-11 2016-08-10 Himerni antigen receptori bazirani na jednodomenskim antitelima i postupci njihove upotrebe
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US15/751,609 US10934363B2 (en) 2015-08-11 2016-08-10 Chimeric antigen receptors based on single domain antibodies and methods of use thereof
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KR1020187006996A KR20180035918A (ko) 2015-08-11 2016-08-10 단일-도메인 항체에 근거된 키메라 항원 수용체 및 이들의 이용 방법
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MX2022015823A MX2022015823A (es) 2015-08-11 2018-02-09 Receptores de antigenos quimerlcos basados en anticuerpos de dominio simple y metodos de uso de estos.
CL2018000378A CL2018000378A1 (es) 2015-08-11 2018-02-09 Receptores de antígenos quiméricos basados en anticuerpos de dominio simple y métodos de uso de estos
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CONC2018/0001405A CO2018001405A2 (es) 2015-08-11 2018-02-13 Receptores de antígenos quiméricos basados en anticuerpos de dominio simple
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US17/164,125 US20210261675A1 (en) 2015-08-11 2021-02-01 Chimeric antigen receptors based on single-domain antibodies and methods of use thereof
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