MX2022015823A - Receptores de antigenos quimerlcos basados en anticuerpos de dominio simple y metodos de uso de estos. - Google Patents

Receptores de antigenos quimerlcos basados en anticuerpos de dominio simple y metodos de uso de estos.

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Publication number
MX2022015823A
MX2022015823A MX2022015823A MX2022015823A MX2022015823A MX 2022015823 A MX2022015823 A MX 2022015823A MX 2022015823 A MX2022015823 A MX 2022015823A MX 2022015823 A MX2022015823 A MX 2022015823A MX 2022015823 A MX2022015823 A MX 2022015823A
Authority
MX
Mexico
Prior art keywords
chimeric antigen
antigen receptors
methods
domain antibodies
receptors based
Prior art date
Application number
MX2022015823A
Other languages
English (en)
Inventor
Xiaohu Fan
Pingyan Wang
Lei Yang
Qiuchuan Zhuang
Jiaying Hao
Lin Wang
Chuan- Chu Chou
Original Assignee
Legend Biotech Ireland Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Legend Biotech Ireland Ltd filed Critical Legend Biotech Ireland Ltd
Publication of MX2022015823A publication Critical patent/MX2022015823A/es

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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • A61K2239/27—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by targeting or presenting multiple antigens
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    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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Abstract

La presente solicitud proporciona anticuerpos de dominio simple, y receptores de antígenos quiméricos que comprenden uno o más dominios de unión al antígeno, cada uno de los cuales comprende un anticuerpo de dominio simple. También se proporcionan células efectoras inmunitarias modificadas genéticamente (tales como linfocitos T) que comprenden los receptores de antígenos quiméricos. También se proporcionan composiciones farmacéuticas, kits y métodos para tratar el cáncer.
MX2022015823A 2015-08-11 2018-02-09 Receptores de antigenos quimerlcos basados en anticuerpos de dominio simple y metodos de uso de estos. MX2022015823A (es)

Applications Claiming Priority (2)

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CN201510490002 2015-08-11
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