MX2019015563A - Anticuerpos anti-bcma unicamente de cadena pesada. - Google Patents
Anticuerpos anti-bcma unicamente de cadena pesada.Info
- Publication number
- MX2019015563A MX2019015563A MX2019015563A MX2019015563A MX2019015563A MX 2019015563 A MX2019015563 A MX 2019015563A MX 2019015563 A MX2019015563 A MX 2019015563A MX 2019015563 A MX2019015563 A MX 2019015563A MX 2019015563 A MX2019015563 A MX 2019015563A
- Authority
- MX
- Mexico
- Prior art keywords
- antibodies
- heavy chain
- bcma
- bcma heavy
- compositions
- Prior art date
Links
- BGFTWECWAICPDG-UHFFFAOYSA-N 2-[bis(4-chlorophenyl)methyl]-4-n-[3-[bis(4-chlorophenyl)methyl]-4-(dimethylamino)phenyl]-1-n,1-n-dimethylbenzene-1,4-diamine Chemical compound C1=C(C(C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C(N(C)C)=CC=C1NC(C=1)=CC=C(N(C)C)C=1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 BGFTWECWAICPDG-UHFFFAOYSA-N 0.000 abstract 1
- 102000006942 B-Cell Maturation Antigen Human genes 0.000 abstract 1
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 abstract 1
- 208000037914 B-cell disorder Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
Se describen anticuerpos anti-BCMA únicamente de cadena pesada (UniAb) junto con métodos para elaborar dichos anticuerpos, composiciones, incluidas las composiciones farmacéuticas que comprenden dichos anticuerpos, y su uso para tratar trastornos de linfocitos B caracterizados por la expresión de BCMA.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762522295P | 2017-06-20 | 2017-06-20 | |
PCT/US2018/038506 WO2018237006A1 (en) | 2017-06-20 | 2018-06-20 | ANTIBODIES ONLY TO HEAVY ANTI-BCMA CHAINS |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019015563A true MX2019015563A (es) | 2020-07-28 |
Family
ID=62875335
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019015563A MX2019015563A (es) | 2017-06-20 | 2018-06-20 | Anticuerpos anti-bcma unicamente de cadena pesada. |
Country Status (9)
Country | Link |
---|---|
US (2) | US11427642B2 (es) |
EP (1) | EP3642236A1 (es) |
JP (2) | JP7240335B2 (es) |
CN (2) | CN117567624A (es) |
AU (1) | AU2018288803A1 (es) |
BR (1) | BR112019026803A2 (es) |
CA (1) | CA3065951A1 (es) |
MX (1) | MX2019015563A (es) |
WO (1) | WO2018237006A1 (es) |
Families Citing this family (13)
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AU2017281034B2 (en) | 2016-06-21 | 2024-03-14 | Teneobio, Inc. | CD3 binding antibodies |
WO2018052503A1 (en) | 2016-09-14 | 2018-03-22 | Teneobio, Inc. | Cd3 binding antibodies |
EP4215548A1 (en) | 2016-12-21 | 2023-07-26 | Teneobio, Inc. | Anti-bcma heavy chain-only antibodies |
WO2018237037A2 (en) | 2017-06-20 | 2018-12-27 | Teneobio, Inc. | HEAVY CHAIN ANTIBODY ONLY ANTI-BCMA |
AU2018288803A1 (en) | 2017-06-20 | 2020-02-06 | Teneoone, Inc. | Anti-BCMA heavy chain-only antibodies |
SG11202005880XA (en) | 2017-12-22 | 2020-07-29 | Teneobio Inc | Heavy chain antibodies binding to cd22 |
AU2019277029C1 (en) | 2018-06-01 | 2024-01-04 | Novartis Ag | Binding molecules against BCMA and uses thereof |
JP2022537931A (ja) | 2019-06-14 | 2022-08-31 | テネオバイオ, インコーポレイテッド | Cd22及びcd3に結合する多重特異性重鎖抗体 |
CN112574308A (zh) * | 2019-09-30 | 2021-03-30 | 和铂医药(苏州)有限公司 | 靶向bcma的抗体、双特异性抗体及其用途 |
BR112022021690A2 (pt) | 2020-04-29 | 2022-12-20 | Teneobio Inc | Anticorpos de cadeia pesada multispecíficos com regiões constantes de cadeia pesada modificadas |
TW202330622A (zh) | 2020-04-29 | 2023-08-01 | 美商泰尼歐生物公司 | 具有經修飾重鏈恆定區之多特異性重鏈抗體 |
WO2022006316A1 (en) * | 2020-06-30 | 2022-01-06 | Teneobio, Inc. | Multi-specific antibodies binding to bcma |
AU2022372894A1 (en) * | 2021-10-20 | 2024-04-18 | Takeda Pharmaceutical Company Limited | Compositions targeting bcma and methods of use thereof |
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TW202330622A (zh) | 2020-04-29 | 2023-08-01 | 美商泰尼歐生物公司 | 具有經修飾重鏈恆定區之多特異性重鏈抗體 |
BR112022021690A2 (pt) | 2020-04-29 | 2022-12-20 | Teneobio Inc | Anticorpos de cadeia pesada multispecíficos com regiões constantes de cadeia pesada modificadas |
WO2022006316A1 (en) | 2020-06-30 | 2022-01-06 | Teneobio, Inc. | Multi-specific antibodies binding to bcma |
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2018
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- 2018-06-20 CN CN202311558572.7A patent/CN117567624A/zh active Pending
- 2018-06-20 CN CN201880038588.6A patent/CN110945026B/zh active Active
- 2018-06-20 JP JP2019571347A patent/JP7240335B2/ja active Active
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- 2018-06-20 MX MX2019015563A patent/MX2019015563A/es unknown
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2022
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CN117567624A (zh) | 2024-02-20 |
JP2020524000A (ja) | 2020-08-13 |
US20230060847A1 (en) | 2023-03-02 |
US11427642B2 (en) | 2022-08-30 |
JP2023071876A (ja) | 2023-05-23 |
AU2018288803A1 (en) | 2020-02-06 |
JP7240335B2 (ja) | 2023-03-15 |
JP7465382B2 (ja) | 2024-04-10 |
EP3642236A1 (en) | 2020-04-29 |
CN110945026B (zh) | 2024-03-19 |
CN110945026A (zh) | 2020-03-31 |
CA3065951A1 (en) | 2018-12-27 |
US20200157232A1 (en) | 2020-05-21 |
BR112019026803A2 (pt) | 2020-06-30 |
WO2018237006A1 (en) | 2018-12-27 |
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