US15133A
(en)
*
|
|
1856-06-17 |
|
Machine fob paring |
US117097A
(en)
*
|
|
1871-07-18 |
|
Improvement in brick-machines |
JPS5144499B1
(ja)
|
1970-08-29 |
1976-11-29 |
|
|
JPS5334319B2
(ja)
|
1971-12-28 |
1978-09-20 |
|
|
JPS5717624B2
(ja)
|
1974-04-17 |
1982-04-12 |
|
|
JPS5484060A
(en)
|
1977-12-12 |
1979-07-04 |
Kyushu Sekisui Kogyo |
Treatment of raw *wakame* by using chlorella extract
|
US4324710A
(en)
|
1980-10-02 |
1982-04-13 |
The Firestone Tire & Rubber Company |
Naturally occurring thermoplastic resins as a substitute for various petroleum-derived materials in rubber stocks
|
US4737456A
(en)
|
1985-05-09 |
1988-04-12 |
Syntex (U.S.A.) Inc. |
Reducing interference in ligand-receptor binding assays
|
US4676980A
(en)
|
1985-09-23 |
1987-06-30 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Target specific cross-linked heteroantibodies
|
US6548640B1
(en)
|
1986-03-27 |
2003-04-15 |
Btg International Limited |
Altered antibodies
|
JPH0234615Y2
(ja)
|
1986-08-08 |
1990-09-18 |
|
|
US5260203A
(en)
*
|
1986-09-02 |
1993-11-09 |
Enzon, Inc. |
Single polypeptide chain binding molecules
|
IL85035A0
(en)
|
1987-01-08 |
1988-06-30 |
Int Genetic Eng |
Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
|
JP3101690B2
(ja)
|
1987-03-18 |
2000-10-23 |
エス・ビィ・2・インコーポレイテッド |
変性抗体の、または変性抗体に関する改良
|
US5004697A
(en)
|
1987-08-17 |
1991-04-02 |
Univ. Of Ca |
Cationized antibodies for delivery through the blood-brain barrier
|
US5606040A
(en)
|
1987-10-30 |
1997-02-25 |
American Cyanamid Company |
Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group
|
US5770701A
(en)
|
1987-10-30 |
1998-06-23 |
American Cyanamid Company |
Process for preparing targeted forms of methyltrithio antitumor agents
|
US5670373A
(en)
*
|
1988-01-22 |
1997-09-23 |
Kishimoto; Tadamitsu |
Antibody to human interleukin-6 receptor
|
US5322678A
(en)
|
1988-02-17 |
1994-06-21 |
Neorx Corporation |
Alteration of pharmacokinetics of proteins by charge modification
|
FR2628833B1
(fr)
|
1988-03-18 |
1993-06-25 |
Pont Sur Sambre Ateliers Mecan |
Dispositif assurant le deconfinement d'une charge militaire contenant un explosif
|
US5126250A
(en)
*
|
1988-09-28 |
1992-06-30 |
Eli Lilly And Company |
Method for the reduction of heterogeneity of monoclonal antibodies
|
CA1332367C
(en)
|
1988-09-28 |
1994-10-11 |
Richard Mark Bartholomew |
Method for the reduction of heterogeneity of monoclonal antibodies
|
US5750373A
(en)
|
1990-12-03 |
1998-05-12 |
Genentech, Inc. |
Enrichment method for variant proteins having altered binding properties, M13 phagemids, and growth hormone variants
|
WO1990005144A1
(en)
|
1988-11-11 |
1990-05-17 |
Medical Research Council |
Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
GB8916400D0
(en)
|
1989-07-18 |
1989-09-06 |
Dynal As |
Modified igg3
|
CA2026147C
(en)
|
1989-10-25 |
2006-02-07 |
Ravi J. Chari |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
US5208020A
(en)
|
1989-10-25 |
1993-05-04 |
Immunogen Inc. |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
US5959177A
(en)
|
1989-10-27 |
1999-09-28 |
The Scripps Research Institute |
Transgenic plants expressing assembled secretory antibodies
|
US5859205A
(en)
|
1989-12-21 |
1999-01-12 |
Celltech Limited |
Humanised antibodies
|
US6150584A
(en)
|
1990-01-12 |
2000-11-21 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
US6075181A
(en)
|
1990-01-12 |
2000-06-13 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
US5770429A
(en)
|
1990-08-29 |
1998-06-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
US5571894A
(en)
|
1991-02-05 |
1996-11-05 |
Ciba-Geigy Corporation |
Recombinant antibodies specific for a growth factor receptor
|
US5795965A
(en)
*
|
1991-04-25 |
1998-08-18 |
Chugai Seiyaku Kabushiki Kaisha |
Reshaped human to human interleukin-6 receptor
|
WO1992022653A1
(en)
|
1991-06-14 |
1992-12-23 |
Genentech, Inc. |
Method for making humanized antibodies
|
US5468634A
(en)
*
|
1991-06-24 |
1995-11-21 |
The University Of North Carolina At Chapel Hill |
Axl oncogene
|
GB9114948D0
(en)
|
1991-07-11 |
1991-08-28 |
Pfizer Ltd |
Process for preparing sertraline intermediates
|
US6136310A
(en)
|
1991-07-25 |
2000-10-24 |
Idec Pharmaceuticals Corporation |
Recombinant anti-CD4 antibodies for human therapy
|
WO1993006217A1
(en)
|
1991-09-19 |
1993-04-01 |
Genentech, Inc. |
EXPRESSION IN E. COLI OF ANTIBODY FRAGMENTS HAVING AT LEAST A CYSTEINE PRESENT AS A FREE THIOL, USE FOR THE PRODUCTION OF BIFUNCTIONAL F(ab')2 ANTIBODIES
|
US5587458A
(en)
|
1991-10-07 |
1996-12-24 |
Aronex Pharmaceuticals, Inc. |
Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof
|
WO1993008829A1
(en)
|
1991-11-04 |
1993-05-13 |
The Regents Of The University Of California |
Compositions that mediate killing of hiv-infected cells
|
ATE419355T1
(de)
|
1992-02-06 |
2009-01-15 |
Novartis Vaccines & Diagnostic |
Marker für krebs und biosynthetisches bindeprotein dafür
|
US6129914A
(en)
|
1992-03-27 |
2000-10-10 |
Protein Design Labs, Inc. |
Bispecific antibody effective to treat B-cell lymphoma and cell line
|
US5639641A
(en)
*
|
1992-09-09 |
1997-06-17 |
Immunogen Inc. |
Resurfacing of rodent antibodies
|
ZA936260B
(en)
|
1992-09-09 |
1994-03-18 |
Smithkline Beecham Corp |
Novel antibodies for conferring passive immunity against infection by a pathogen in man
|
BR9204244A
(pt)
|
1992-10-26 |
1994-05-03 |
Cofap |
Ferro fundido cinzento
|
ES2091684T3
(es)
|
1992-11-13 |
1996-11-01 |
Idec Pharma Corp |
Aplicacion terapeutica de anticuerpos quimericos y radiomarcados contra el antigeno de diferenciacion restringida de los linfocitos b humanos para el tratamiento del linfoma de las celulas b.
|
AU689090B2
(en)
|
1992-12-01 |
1998-03-26 |
Protein Design Labs, Inc. |
Humanized antibodies reactive with L-selectin
|
US5635483A
(en)
|
1992-12-03 |
1997-06-03 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Tumor inhibiting tetrapeptide bearing modified phenethyl amides
|
US5780588A
(en)
|
1993-01-26 |
1998-07-14 |
Arizona Board Of Regents |
Elucidation and synthesis of selected pentapeptides
|
AU691811B2
(en)
|
1993-06-16 |
1998-05-28 |
Celltech Therapeutics Limited |
Antibodies
|
US5888510A
(en)
*
|
1993-07-21 |
1999-03-30 |
Chugai Seiyaku Kabushiki Kaisha |
Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component
|
UA40577C2
(uk)
|
1993-08-02 |
2001-08-15 |
Мерк Патент Гмбх |
Біспецифічна молекула, що використовується для лізису пухлинних клітин, спосіб її одержання, моноклональне антитіло (варіанти), фармацевтичний препарат, фармацевтичний набір (варіанти), спосіб видалення пухлинних клітин
|
IL107742A0
(en)
|
1993-11-24 |
1994-02-27 |
Yeda Res & Dev |
Chemically-modified binding proteins
|
US5773001A
(en)
|
1994-06-03 |
1998-06-30 |
American Cyanamid Company |
Conjugates of methyltrithio antitumor agents and intermediates for their synthesis
|
US5945311A
(en)
*
|
1994-06-03 |
1999-08-31 |
GSF--Forschungszentrumfur Umweltund Gesundheit |
Method for producing heterologous bi-specific antibodies
|
DE4419399C1
(de)
|
1994-06-03 |
1995-03-09 |
Gsf Forschungszentrum Umwelt |
Verfahren zur Herstellung von heterologen bispezifischen Antikörpern
|
US8017121B2
(en)
*
|
1994-06-30 |
2011-09-13 |
Chugai Seiyaku Kabushika Kaisha |
Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component
|
US6309636B1
(en)
|
1995-09-14 |
2001-10-30 |
Cancer Research Institute Of Contra Costa |
Recombinant peptides derived from the Mc3 anti-BA46 antibody, methods of use thereof, and methods of humanizing antibody peptides
|
EP2107070A1
(en)
|
1994-10-07 |
2009-10-07 |
Chugai Seiyaku Kabushiki Kaisha |
Rheumatoid arthritis remedy containing IL-6 antagonist as active ingredient
|
CN1306963C
(zh)
|
1994-10-21 |
2007-03-28 |
岸本忠三 |
用于治疗il-6产生所致疾病的药物组合物
|
US5789199A
(en)
|
1994-11-03 |
1998-08-04 |
Genentech, Inc. |
Process for bacterial production of polypeptides
|
US6485943B2
(en)
|
1995-01-17 |
2002-11-26 |
The University Of Chicago |
Method for altering antibody light chain interactions
|
US5876950A
(en)
|
1995-01-26 |
1999-03-02 |
Bristol-Myers Squibb Company |
Monoclonal antibodies specific for different epitopes of human GP39 and methods for their use in diagnosis and therapy
|
DK0812136T3
(da)
|
1995-02-28 |
2001-02-19 |
Procter & Gamble |
Fremgangsmåde til fremstilling af ikke-kulsyreholdige læskedrikke med bedre mikrobiel stabilitet
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
US5840523A
(en)
|
1995-03-01 |
1998-11-24 |
Genetech, Inc. |
Methods and compositions for secretion of heterologous polypeptides
|
US5869046A
(en)
|
1995-04-14 |
1999-02-09 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
US5714586A
(en)
|
1995-06-07 |
1998-02-03 |
American Cyanamid Company |
Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates
|
US5712374A
(en)
|
1995-06-07 |
1998-01-27 |
American Cyanamid Company |
Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
|
US6267958B1
(en)
|
1995-07-27 |
2001-07-31 |
Genentech, Inc. |
Protein formulation
|
ES2233974T3
(es)
*
|
1995-09-11 |
2005-06-16 |
Kyowa Hakko Kogyo Co., Ltd. |
Anticuerpo contra la cadena alfa del receptor de la interleucina 5 humana.
|
GB9603256D0
(en)
|
1996-02-16 |
1996-04-17 |
Wellcome Found |
Antibodies
|
US20020147326A1
(en)
|
1996-06-14 |
2002-10-10 |
Smithkline Beecham Corporation |
Hexameric fusion proteins and uses therefor
|
IL127872A0
(en)
|
1996-07-19 |
1999-10-28 |
Amgen Inc |
Analogs of cationic proteins
|
US5990286A
(en)
|
1996-12-18 |
1999-11-23 |
Techniclone, Inc. |
Antibodies with reduced net positive charge
|
CA2284271C
(en)
|
1997-03-21 |
2012-05-08 |
Chugai Seiyaku Kabushiki Kaisha |
A preventive or therapeutic agent for sensitized t cell-mediated diseases comprising il-6 antagonist as an active ingredient
|
US6884879B1
(en)
|
1997-04-07 |
2005-04-26 |
Genentech, Inc. |
Anti-VEGF antibodies
|
US20070059302A1
(en)
*
|
1997-04-07 |
2007-03-15 |
Genentech, Inc. |
Anti-vegf antibodies
|
ES2246069T3
(es)
|
1997-05-02 |
2006-02-01 |
Genentech, Inc. |
Procedimiento de preparacion de anticuerpos multiespecificos que tienen componentes comunes y multimericos.
|
US6171586B1
(en)
|
1997-06-13 |
2001-01-09 |
Genentech, Inc. |
Antibody formulation
|
JP2002506353A
(ja)
|
1997-06-24 |
2002-02-26 |
ジェネンテック・インコーポレーテッド |
ガラクトシル化糖タンパク質の方法及び組成物
|
US5980893A
(en)
|
1997-07-17 |
1999-11-09 |
Beth Israel Deaconess Medical Center, Inc. |
Agonist murine monoclonal antibody as a stimulant for megakaryocytopoiesis
|
US6040498A
(en)
|
1998-08-11 |
2000-03-21 |
North Caroline State University |
Genetically engineered duckweed
|
KR20010022846A
(ko)
|
1997-08-15 |
2001-03-26 |
나가야마 오사무 |
항 인터루킨-6 수용체 항체를 유효성분으로서 함유하는 전신성 홍반성 낭창의 예방 및/또는 치료제
|
US20020187150A1
(en)
*
|
1997-08-15 |
2002-12-12 |
Chugai Seiyaku Kabushiki Kaisha |
Preventive and/or therapeutic agent for systemic lupus erythematosus comprising anti-IL-6 receptor antibody as an active ingredient
|
BR9812846A
(pt)
|
1997-10-03 |
2000-08-08 |
Chugai Pharmaceutical Co Ltd |
Anticorpo humanizado natural
|
AU759779B2
(en)
|
1997-10-31 |
2003-05-01 |
Genentech Inc. |
Methods and compositions comprising glycoprotein glycoforms
|
US6610833B1
(en)
|
1997-11-24 |
2003-08-26 |
The Institute For Human Genetics And Biochemistry |
Monoclonal human natural antibodies
|
EP1034298B1
(en)
|
1997-12-05 |
2011-11-02 |
The Scripps Research Institute |
Humanization of murine antibody
|
JP4124573B2
(ja)
|
1998-03-17 |
2008-07-23 |
中外製薬株式会社 |
Il−6アンタゴニストを有効成分として含有する炎症性腸疾患の予防又は治療剤
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
ATE375365T1
(de)
|
1998-04-02 |
2007-10-15 |
Genentech Inc |
Antikörper varianten und fragmente davon
|
BR9909382A
(pt)
|
1998-04-03 |
2000-12-05 |
Chugai Pharmaceutical Co Ltd |
Anticorpo humanizado contra o fator tissular humano (tf) e processo de produção de anticorpo humanizado
|
EP2261229A3
(en)
|
1998-04-20 |
2011-03-23 |
GlycArt Biotechnology AG |
Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity
|
GB9809951D0
(en)
|
1998-05-08 |
1998-07-08 |
Univ Cambridge Tech |
Binding molecules
|
JP2002522063A
(ja)
*
|
1998-08-17 |
2002-07-23 |
アブジェニックス インコーポレイテッド |
増加した血清半減期を有する改変された分子の生成
|
DE69942671D1
(de)
*
|
1998-12-01 |
2010-09-23 |
Facet Biotech Corp |
Humanisierte antikoerper gegen gamma-interferon
|
JP2002534959A
(ja)
|
1998-12-08 |
2002-10-22 |
バイオベーション リミテッド |
免疫原性タンパク質の改変方法
|
CA2359067C
(en)
|
1999-01-15 |
2017-03-14 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
US6972125B2
(en)
*
|
1999-02-12 |
2005-12-06 |
Genetics Institute, Llc |
Humanized immunoglobulin reactive with B7-2 and methods of treatment therewith
|
EP2264166B1
(en)
|
1999-04-09 |
2016-03-23 |
Kyowa Hakko Kirin Co., Ltd. |
Method for controlling the activity of immunologically functional molecule
|
AU4952400A
(en)
|
1999-06-02 |
2000-12-28 |
Chugai Research Institute For Molecular Medicine, Inc. |
Novel hemopoietin receptor protein nr10
|
SK782002A3
(en)
|
1999-07-21 |
2003-08-05 |
Lexigen Pharm Corp |
FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens
|
US7125978B1
(en)
|
1999-10-04 |
2006-10-24 |
Medicago Inc. |
Promoter for regulating expression of foreign genes
|
NZ517906A
(en)
|
1999-10-04 |
2003-01-31 |
Medicago Inc |
Cloning of genomic sequences encoding nitrite reductase (NiR) for use in regulated expression of foreign genes in host plants
|
CA2388245C
(en)
|
1999-10-19 |
2012-01-10 |
Tatsuya Ogawa |
The use of serum-free adapted rat cells for producing heterologous polypeptides
|
SE9903895D0
(sv)
|
1999-10-28 |
1999-10-28 |
Active Biotech Ab |
Novel compounds
|
WO2001044463A1
(en)
|
1999-12-15 |
2001-06-21 |
Genentech, Inc. |
Shotgun scanning, a combinatorial method for mapping functional protein epitopes
|
WO2001049698A1
(en)
|
1999-12-29 |
2001-07-12 |
Immunogen, Inc. |
Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use
|
JP2004505609A
(ja)
*
|
2000-04-03 |
2004-02-26 |
オックスフォード グリコサイエンシズ(ユーケー) リミテッド |
核酸分子、ポリペプチド、ならびにアルツハイマー病の診断および処置を含むそれらの使用
|
HUP0300369A2
(hu)
|
2000-04-11 |
2003-06-28 |
Genentech, Inc. |
Többértékű antitestek és alkalmazásuk
|
WO2001082899A2
(en)
|
2000-05-03 |
2001-11-08 |
Mbt Munich Biotechnology Ag |
Cationic diagnostic, imaging and therapeutic agents associated with activated vascular sites
|
DK2314686T4
(da)
|
2000-10-06 |
2023-08-21 |
Kyowa Kirin Co Ltd |
Celler, der danner antistofsammensætninger
|
US6946292B2
(en)
|
2000-10-06 |
2005-09-20 |
Kyowa Hakko Kogyo Co., Ltd. |
Cells producing antibody compositions with increased antibody dependent cytotoxic activity
|
US7064191B2
(en)
|
2000-10-06 |
2006-06-20 |
Kyowa Hakko Kogyo Co., Ltd. |
Process for purifying antibody
|
WO2002034292A1
(fr)
|
2000-10-25 |
2002-05-02 |
Chugai Seiyaku Kabushiki Kaisha |
Agents preventifs ou therapeutiques contre le psoriasis renfermant l'antagoniste de l'il-6 comme substance active
|
JP4889187B2
(ja)
*
|
2000-10-27 |
2012-03-07 |
中外製薬株式会社 |
Il−6アンタゴニストを有効成分として含有する血中mmp−3濃度低下剤
|
US6596541B2
(en)
|
2000-10-31 |
2003-07-22 |
Regeneron Pharmaceuticals, Inc. |
Methods of modifying eukaryotic cells
|
ES2295228T3
(es)
|
2000-11-30 |
2008-04-16 |
Medarex, Inc. |
Roedores transcromosomicos transgenicos para la preparacion de anticuerpos humanos.
|
US7083784B2
(en)
|
2000-12-12 |
2006-08-01 |
Medimmune, Inc. |
Molecules with extended half-lives, compositions and uses thereof
|
PL206701B1
(pl)
|
2001-03-07 |
2010-09-30 |
Merck Patent Gmbh |
Immunoglobulinowe białko fuzyjne, kodujący je kwas nukleinowy, replikujący wektor ekspresji zawierający taki kwas nukleinowy, eukariotyczna komórka gospodarza zawierająca taki wektor ekspresji oraz sposób zwiększania ekspresji takiego białka fuzyjnego
|
UA80091C2
(en)
|
2001-04-02 |
2007-08-27 |
Chugai Pharmaceutical Co Ltd |
Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist
|
PL367324A1
(en)
*
|
2001-04-13 |
2005-02-21 |
Biogen, Inc. |
Antibodies to vla-1
|
CN1314803C
(zh)
*
|
2001-06-22 |
2007-05-09 |
中外制药株式会社 |
含有抗磷脂酰肌醇蛋白聚糖3抗体的细胞生长抑制剂
|
US6833441B2
(en)
|
2001-08-01 |
2004-12-21 |
Abmaxis, Inc. |
Compositions and methods for generating chimeric heteromultimers
|
HUP0700103A3
(en)
|
2001-08-03 |
2012-09-28 |
Glycart Biotechnology Ag |
Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity
|
US20030049203A1
(en)
|
2001-08-31 |
2003-03-13 |
Elmaleh David R. |
Targeted nucleic acid constructs and uses related thereto
|
ATE430580T1
(de)
|
2001-10-25 |
2009-05-15 |
Genentech Inc |
Glycoprotein-zusammensetzungen
|
US20030190705A1
(en)
|
2001-10-29 |
2003-10-09 |
Sunol Molecular Corporation |
Method of humanizing immune system molecules
|
CN1292655C
(zh)
|
2001-11-08 |
2007-01-03 |
蛋白质设计实验室股份有限公司 |
IgG抗体稳定的液态药物制剂
|
US20040093621A1
(en)
|
2001-12-25 |
2004-05-13 |
Kyowa Hakko Kogyo Co., Ltd |
Antibody composition which specifically binds to CD20
|
EP1464702A4
(en)
|
2001-12-28 |
2005-09-21 |
Chugai Pharmaceutical Co Ltd |
METHOD FOR PROTEIN STABILIZATION
|
EP1576112B1
(en)
*
|
2002-01-18 |
2012-02-29 |
ZymoGenetics, Inc. |
Cytokine receptor zcytor17 multimers
|
US7064186B2
(en)
*
|
2002-01-18 |
2006-06-20 |
Zymogenetics, Inc. |
Cytokine zcytor17 ligand
|
JP2006506943A
(ja)
*
|
2002-02-11 |
2006-03-02 |
ジェネンテック・インコーポレーテッド |
抗原結合速度の大きい抗体変異体
|
WO2003074679A2
(en)
|
2002-03-01 |
2003-09-12 |
Xencor |
Antibody optimization
|
US8188231B2
(en)
*
|
2002-09-27 |
2012-05-29 |
Xencor, Inc. |
Optimized FC variants
|
US7736652B2
(en)
|
2002-03-21 |
2010-06-15 |
The Regents Of The University Of California |
Antibody fusion proteins: effective adjuvants of protein vaccination
|
MXPA04009924A
(es)
|
2002-04-09 |
2005-07-01 |
Kyowa Hakko Kogyo Kk |
Celulas de genoma modificado.
|
US20050031613A1
(en)
|
2002-04-09 |
2005-02-10 |
Kazuyasu Nakamura |
Therapeutic agent for patients having human FcgammaRIIIa
|
ES2362419T3
(es)
|
2002-04-09 |
2011-07-05 |
Kyowa Hakko Kirin Co., Ltd. |
Células con depresión o deleción de la actividad de la proteína que participa en el transporte de gdp-fucosa.
|
JPWO2003085118A1
(ja)
|
2002-04-09 |
2005-08-11 |
協和醗酵工業株式会社 |
抗体組成物の製造方法
|
EP1498491A4
(en)
|
2002-04-09 |
2006-12-13 |
Kyowa Hakko Kogyo Kk |
METHOD FOR INCREASING THE ACTIVITY OF AN ANTIBODY COMPOSITION FOR BINDING TO THE FC GAMMA RECEPTOR IIIA
|
EP1500400A4
(en)
|
2002-04-09 |
2006-10-11 |
Kyowa Hakko Kogyo Kk |
MEDICAMENT WITH ANTIBODY COMPOSITION
|
EP1495055B1
(en)
|
2002-04-18 |
2013-08-14 |
Genencor International, Inc. |
Production of functional antibodies in filamentous fungi
|
WO2005056606A2
(en)
*
|
2003-12-03 |
2005-06-23 |
Xencor, Inc |
Optimized antibodies that target the epidermal growth factor receptor
|
JP2004086862A
(ja)
|
2002-05-31 |
2004-03-18 |
Celestar Lexico-Sciences Inc |
タンパク質相互作用情報処理装置、タンパク質相互作用情報処理方法、プログラム、および、記録媒体
|
EP1510943A4
(en)
|
2002-05-31 |
2007-05-09 |
Celestar Lexico Sciences Inc |
INTERACTION PREDICTION DEVICE
|
AU2003239966B9
(en)
|
2002-06-03 |
2010-08-26 |
Genentech, Inc. |
Synthetic antibody phage libraries
|
AU2003256266A1
(en)
|
2002-06-12 |
2003-12-31 |
Genencor International, Inc. |
Methods and compositions for milieu-dependent binding of a targeted agent to a target
|
EP1382969A1
(en)
|
2002-07-17 |
2004-01-21 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Diagnosis and prevention of cancer cell invasion
|
TW200407335A
(en)
*
|
2002-07-22 |
2004-05-16 |
Chugai Pharmaceutical Co Ltd |
Non-neutralizing antibody to inhibit the inactivation of activated protein C
|
US20040086979A1
(en)
|
2002-08-15 |
2004-05-06 |
Dongxiao Zhang |
Humanized rabbit antibodies
|
US7217797B2
(en)
|
2002-10-15 |
2007-05-15 |
Pdl Biopharma, Inc. |
Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
|
EP1562972B1
(en)
|
2002-10-15 |
2010-09-08 |
Facet Biotech Corporation |
ALTERATION OF FcRn BINDING AFFINITIES OR SERUM HALF-LIVES OF ANTIBODIES BY MUTAGENESIS
|
US7361740B2
(en)
|
2002-10-15 |
2008-04-22 |
Pdl Biopharma, Inc. |
Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
|
GB0224082D0
(en)
|
2002-10-16 |
2002-11-27 |
Celltech R&D Ltd |
Biological products
|
EP3263596A1
(en)
|
2002-12-16 |
2018-01-03 |
Genentech, Inc. |
Immunoglobulin variants and uses thereof
|
DK1575517T3
(da)
*
|
2002-12-24 |
2012-05-14 |
Rinat Neuroscience Corp |
Anti-ngf-antistoffer og fremgangsmåder til anvendelse af samme
|
EP1585767A2
(en)
|
2003-01-16 |
2005-10-19 |
Genentech, Inc. |
Synthetic antibody phage libraries
|
CA2515081A1
(en)
|
2003-02-07 |
2004-08-19 |
Protein Design Labs, Inc. |
Amphiregulin antibodies and their use to treat cancer and psoriasis
|
US20040223970A1
(en)
*
|
2003-02-28 |
2004-11-11 |
Daniel Afar |
Antibodies against SLC15A2 and uses thereof
|
EP1605974B1
(en)
|
2003-03-04 |
2014-11-12 |
Alexion Pharmaceuticals, Inc. |
Method of treating autoimmune disease by inducing antigen presentation by tolerance inducing antigen presenting cells
|
US7871607B2
(en)
|
2003-03-05 |
2011-01-18 |
Halozyme, Inc. |
Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
|
US20060104968A1
(en)
|
2003-03-05 |
2006-05-18 |
Halozyme, Inc. |
Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
|
EA009124B1
(ru)
|
2003-03-24 |
2007-10-26 |
Займоджинетикс, Инк. |
Антитела против il-20 и связывающие партнеры, а также способы их применения при воспалении
|
JP2004321100A
(ja)
|
2003-04-25 |
2004-11-18 |
Rikogaku Shinkokai |
IgGのFc領域を含むタンパク質の変異体
|
GB2401040A
(en)
|
2003-04-28 |
2004-11-03 |
Chugai Pharmaceutical Co Ltd |
Method for treating interleukin-6 related diseases
|
ES2408582T3
(es)
*
|
2003-05-30 |
2013-06-21 |
Merus B.V. |
Biblioteca de Fab para la preparación de una mezcla de anticuerpos
|
CA2526402A1
(en)
|
2003-06-05 |
2005-01-20 |
Genentech, Inc. |
Blys antagonists and uses thereof
|
WO2004113387A2
(en)
|
2003-06-24 |
2004-12-29 |
Merck Patent Gmbh |
Tumour necrosis factor receptor molecules with reduced immunogenicity
|
US20050033029A1
(en)
|
2003-06-30 |
2005-02-10 |
Jin Lu |
Engineered anti-target immunoglobulin derived proteins, compositions, methods and uses
|
JP2005101105A
(ja)
|
2003-09-22 |
2005-04-14 |
Canon Inc |
位置決め装置、露光装置、デバイス製造方法
|
US20060134105A1
(en)
*
|
2004-10-21 |
2006-06-22 |
Xencor, Inc. |
IgG immunoglobulin variants with optimized effector function
|
AU2004279742A1
(en)
|
2003-10-08 |
2005-04-21 |
Kyowa Hakko Kirin Co., Ltd. |
Fused protein composition
|
EP1705251A4
(en)
|
2003-10-09 |
2009-10-28 |
Kyowa Hakko Kirin Co Ltd |
PROCESS FOR PRODUCING ANTIBODY COMPOSITION BY RNA INHIBITION OF FUNCTION OF $ G (A) 1,6-FUCOSYLTRANSFERASE
|
AU2003271174A1
(en)
|
2003-10-10 |
2005-04-27 |
Chugai Seiyaku Kabushiki Kaisha |
Double specific antibodies substituting for functional protein
|
AU2003271186A1
(en)
|
2003-10-14 |
2005-04-27 |
Chugai Seiyaku Kabushiki Kaisha |
Double specific antibodies substituting for functional protein
|
WO2005037867A1
(en)
|
2003-10-15 |
2005-04-28 |
Pdl Biopharma, Inc. |
ALTERATION OF Fc-FUSION PROTEIN SERUM HALF-LIVES BY MUTAGENESIS OF POSITIONS 250, 314 AND/OR 428 OF THE HEAVY CHAIN CONSTANT REGION OF IG
|
EP1690550B1
(en)
|
2003-10-17 |
2012-08-08 |
Chugai Seiyaku Kabushiki Kaisha |
Therapeutic agent for mesothelioma
|
DK2348051T3
(en)
|
2003-11-05 |
2019-03-18 |
Roche Glycart Ag |
CD20 antibodies with increased fc receptor binding affinity and effector function
|
CN107213469A
(zh)
|
2003-11-06 |
2017-09-29 |
西雅图基因公司 |
能够与配体偶联的单甲基缬氨酸化合物
|
EP2385069A3
(en)
|
2003-11-12 |
2012-05-30 |
Biogen Idec MA Inc. |
Neonatal Fc rReceptor (FcRn)- binding polypeptide variants, dimeric Fc binding proteins and methods related thereto
|
JPWO2005053742A1
(ja)
|
2003-12-04 |
2007-06-28 |
協和醗酵工業株式会社 |
抗体組成物を含有する医薬
|
HUE025328T2
(en)
*
|
2003-12-10 |
2016-03-29 |
Squibb & Sons Llc |
IP-10 antibodies and their use
|
EP1711207B1
(en)
|
2003-12-10 |
2012-11-28 |
Medarex, Inc. |
Interferon alpha antibodies and their uses
|
AR048210A1
(es)
|
2003-12-19 |
2006-04-12 |
Chugai Pharmaceutical Co Ltd |
Un agente preventivo para la vasculitis.
|
JP2007515493A
(ja)
|
2003-12-22 |
2007-06-14 |
セントカー・インコーポレーテツド |
多量体分子を生成する方法
|
NZ548325A
(en)
|
2003-12-25 |
2009-07-31 |
Kirin Pharma Kk |
Mutants of anti-CD40 antibody
|
PL1699822T3
(pl)
*
|
2003-12-30 |
2008-08-29 |
Merck Patent Gmbh |
Białka fuzyjne IL-7 z częściami przeciwciała, ich otrzymywanie oraz ich zastosowanie
|
EA012872B1
(ru)
|
2004-01-09 |
2009-12-30 |
Пфайзер Инк. |
АНТИТЕЛА ПРОТИВ MAdCAM
|
ATE464908T1
(de)
|
2004-02-11 |
2010-05-15 |
Warner Lambert Co |
Verfahren zur behandlung von osteoarthritis mit anti-il-6 antikörpern
|
EP2053062A1
(en)
|
2004-03-24 |
2009-04-29 |
Xencor, Inc. |
Immunoglobin variants outside the Fc region
|
EP3736295A1
(en)
|
2004-03-24 |
2020-11-11 |
Chugai Seiyaku Kabushiki Kaisha |
Subtypes of humanized antibody against interleukin-6 receptor
|
KR20070035482A
(ko)
|
2004-03-24 |
2007-03-30 |
추가이 세이야쿠 가부시키가이샤 |
인터로킨-6 안타고니스트를 활성성분으로 함유하는내이장해 치료제
|
AR048335A1
(es)
|
2004-03-24 |
2006-04-19 |
Chugai Pharmaceutical Co Ltd |
Agentes terapeuticos para trastornos del oido interno que contienen un antagonista de il- 6 como un ingrediente activo
|
NZ550217A
(en)
|
2004-03-31 |
2009-11-27 |
Genentech Inc |
Humanized anti-TGF-beta antibodies
|
WO2005123780A2
(en)
|
2004-04-09 |
2005-12-29 |
Protein Design Labs, Inc. |
Alteration of fcrn binding affinities or serum half-lives of antibodies by mutagenesis
|
US7785903B2
(en)
|
2004-04-09 |
2010-08-31 |
Genentech, Inc. |
Variable domain library and uses
|
NZ578643A
(en)
|
2004-04-13 |
2010-11-26 |
Hoffmann La Roche |
Anti-P-selectin antibodies
|
WO2005112564A2
(en)
|
2004-04-15 |
2005-12-01 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Germline and sequence variants of humanized antibodies and methods of making and using them
|
KR100620554B1
(ko)
|
2004-06-05 |
2006-09-06 |
한국생명공학연구원 |
Tag-72에 대한 인간화 항체
|
AR049390A1
(es)
|
2004-06-09 |
2006-07-26 |
Wyeth Corp |
Anticuerpos contra la interleuquina-13 humana y usos de los mismos
|
US20060019342A1
(en)
*
|
2004-06-25 |
2006-01-26 |
Medimmune, Inc. |
Increasing the production of recombinant antibodies in mammalian cells by site-directed mutagenesis
|
JP4939410B2
(ja)
|
2004-07-06 |
2012-05-23 |
バイオレン,インク. |
強化された特性を持つ変性ポリペプチドを発生させるためのルックスルー変異誘発
|
KR100863776B1
(ko)
|
2004-07-15 |
2008-10-16 |
젠코어 인코포레이티드 |
최적화된 Fc 변이체
|
AU2005285347A1
(en)
|
2004-08-19 |
2006-03-23 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
CA2577082A1
(en)
*
|
2004-09-02 |
2006-03-16 |
Genentech, Inc. |
Heteromultimeric molecules
|
WO2006031825A2
(en)
|
2004-09-13 |
2006-03-23 |
Macrogenics, Inc. |
Humanized antibodies against west nile virus and therapeutic and prophylactic uses thereof
|
CA2580319A1
(en)
|
2004-09-14 |
2006-03-23 |
National Institute For Biological Standards And Control |
Vaccine
|
WO2006031994A2
(en)
|
2004-09-14 |
2006-03-23 |
Xencor, Inc. |
Monomeric immunoglobulin fc domains
|
US7563443B2
(en)
|
2004-09-17 |
2009-07-21 |
Domantis Limited |
Monovalent anti-CD40L antibody polypeptides and compositions thereof
|
TWI309240B
(en)
|
2004-09-17 |
2009-05-01 |
Hoffmann La Roche |
Anti-ox40l antibodies
|
WO2006033386A1
(ja)
|
2004-09-22 |
2006-03-30 |
Kirin Beer Kabushiki Kaisha |
安定化されたヒトIgG4抗体
|
TR201808537T4
(tr)
|
2004-09-23 |
2018-07-23 |
Genentech Inc |
Sistein değiştirilmiş antikorlar ve konjugatlar.
|
JO3000B1
(ar)
|
2004-10-20 |
2016-09-05 |
Genentech Inc |
مركبات أجسام مضادة .
|
WO2006047350A2
(en)
|
2004-10-21 |
2006-05-04 |
Xencor, Inc. |
IgG IMMUNOGLOBULIN VARIANTS WITH OPTIMIZED EFFECTOR FUNCTION
|
KR101370253B1
(ko)
*
|
2004-10-22 |
2014-03-05 |
암젠 인크 |
재조합 항체의 재접힘 방법
|
US20060115485A1
(en)
|
2004-10-29 |
2006-06-01 |
Medimmune, Inc. |
Methods of preventing and treating RSV infections and related conditions
|
US7462697B2
(en)
|
2004-11-08 |
2008-12-09 |
Epitomics, Inc. |
Methods for antibody engineering
|
US7632497B2
(en)
*
|
2004-11-10 |
2009-12-15 |
Macrogenics, Inc. |
Engineering Fc Antibody regions to confer effector function
|
EP2325206B1
(en)
|
2004-11-12 |
2014-03-19 |
Xencor, Inc. |
Fc variants with altered binding to fcrn
|
US8802820B2
(en)
|
2004-11-12 |
2014-08-12 |
Xencor, Inc. |
Fc variants with altered binding to FcRn
|
JP5787461B2
(ja)
|
2004-12-14 |
2015-09-30 |
ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ |
免疫グロブリンの精製方法
|
JPWO2006067847A1
(ja)
*
|
2004-12-22 |
2008-06-12 |
中外製薬株式会社 |
フコーストランスポーターの機能が阻害された細胞を用いた抗体の作製方法
|
US8728828B2
(en)
|
2004-12-22 |
2014-05-20 |
Ge Healthcare Bio-Sciences Ab |
Purification of immunoglobulins
|
CA2592015A1
(en)
|
2004-12-27 |
2006-07-06 |
Progenics Pharmaceuticals (Nevada), Inc. |
Orally deliverable and anti-toxin antibodies and methods for making and using them
|
NO346624B1
(no)
|
2004-12-28 |
2022-11-07 |
Univ Di Genova |
Monoklonale antistoff mot NKG2A
|
US20090298195A1
(en)
|
2005-01-05 |
2009-12-03 |
F-Star Biotechnologische Forschungs-Und Entwicklun Gseges M.B.H. |
Synthetic immunoglobulin domains with binding properties engineered in regions of the molecule different from the complementarity determining regions
|
US20060275282A1
(en)
*
|
2005-01-12 |
2006-12-07 |
Xencor, Inc. |
Antibodies and Fc fusion proteins with altered immunogenicity
|
JP4986633B2
(ja)
|
2005-01-12 |
2012-07-25 |
協和発酵キリン株式会社 |
安定化されたヒトIgG2およびIgG3抗体
|
WO2006088855A1
(en)
*
|
2005-02-14 |
2006-08-24 |
Zymogenetics, Inc. |
Methods of treating skin disorders using an il-31ra antagonist
|
US7700099B2
(en)
*
|
2005-02-14 |
2010-04-20 |
Merck & Co., Inc. |
Non-immunostimulatory antibody and compositions containing the same
|
JP5620626B2
(ja)
|
2005-03-31 |
2014-11-05 |
中外製薬株式会社 |
会合制御によるポリペプチド製造方法
|
TW200722518A
(en)
|
2005-03-31 |
2007-06-16 |
Chugai Pharmaceutical Co Ltd |
Sc(fv)2 structural isomers
|
CA2957144C
(en)
|
2005-04-08 |
2020-06-02 |
Chugai Seiyaku Kabushiki Kaisha |
Antibody substituting for function of blood coagulation factor viii
|
CA2605037C
(en)
|
2005-04-15 |
2015-02-24 |
Genentech, Inc. |
Hgf beta chain variants
|
EP1874816A4
(en)
|
2005-04-26 |
2010-08-25 |
Medimmune Inc |
MODULATION OF THE ANTIBODY EFFECTOR FUNCTION BY "HINGE" DOMENGINE ENGINEERING
|
PA8672101A1
(es)
|
2005-04-29 |
2006-12-07 |
Centocor Inc |
Anticuerpos anti-il-6, composiciones, métodos y usos
|
PE20061323A1
(es)
|
2005-04-29 |
2007-02-09 |
Rinat Neuroscience Corp |
Anticuerpos dirigidos contra el peptido amiloide beta y metodos que utilizan los mismos
|
US8003108B2
(en)
|
2005-05-03 |
2011-08-23 |
Amgen Inc. |
Sclerostin epitopes
|
CA2607281C
(en)
|
2005-05-05 |
2023-10-03 |
Duke University |
Anti-cd19 antibody therapy for autoimmune disease
|
JP5224580B2
(ja)
|
2005-06-10 |
2013-07-03 |
中外製薬株式会社 |
sc(Fv)2部位特異的変異体
|
AU2006256041B2
(en)
|
2005-06-10 |
2012-03-29 |
Chugai Seiyaku Kabushiki Kaisha |
Stabilizer for protein preparation comprising meglumine and use thereof
|
WO2007002543A2
(en)
|
2005-06-23 |
2007-01-04 |
Medimmune, Inc. |
Antibody formulations having optimized aggregation and fragmentation profiles
|
EP1907002A2
(en)
|
2005-07-11 |
2008-04-09 |
Macrogenics, Inc. |
Methods of treating autoimmune disease using humanized anti-cd16a antibodies
|
PT1919503E
(pt)
|
2005-08-10 |
2015-01-05 |
Macrogenics Inc |
Identificação e manipulação de anticorpos com a regiões de fc variantes e métodos de utilização dos mesmos
|
JP5415071B2
(ja)
|
2005-08-19 |
2014-02-12 |
ワイス・エルエルシー |
Gdf−8に対するアンタゴニスト抗体ならびにalsおよびその他のgdf−8関連障害の処置における使用
|
WO2007032634A1
(en)
|
2005-09-12 |
2007-03-22 |
Industry Foundation Of Chonnam National University |
A method for production of mature natural killer cell
|
CA2622772A1
(en)
*
|
2005-09-29 |
2007-04-12 |
Viral Logic Systems Technology Corp. |
Immunomodulatory compositions and uses therefor
|
WO2007043641A1
(ja)
|
2005-10-14 |
2007-04-19 |
Fukuoka University |
膵島移植における移植膵島障害抑制剤
|
US8945558B2
(en)
|
2005-10-21 |
2015-02-03 |
Chugai Seiyaku Kabushiki Kaisha |
Methods for treating myocardial infarction comprising administering an IL-6 inhibitor
|
EP2465870A1
(en)
|
2005-11-07 |
2012-06-20 |
Genentech, Inc. |
Binding polypeptides with diversified and consensus VH/VL hypervariable sequences
|
AR057582A1
(es)
|
2005-11-15 |
2007-12-05 |
Nat Hospital Organization |
Agentes para suprimir la induccion de linfocitos t citotoxicos
|
WO2007060411A1
(en)
|
2005-11-24 |
2007-05-31 |
Ucb Pharma S.A. |
Anti-tnf alpha antibodies which selectively inhibit tnf alpha signalling through the p55r
|
US20090269335A1
(en)
|
2005-11-25 |
2009-10-29 |
Keio University |
Therapeutic agent for prostate cancer
|
EP1973951A2
(en)
|
2005-12-02 |
2008-10-01 |
Genentech, Inc. |
Binding polypeptides with restricted diversity sequences
|
WO2007074880A1
(ja)
|
2005-12-28 |
2007-07-05 |
Chugai Seiyaku Kabushiki Kaisha |
抗体含有安定化製剤
|
JP2009526756A
(ja)
|
2006-01-10 |
2009-07-23 |
ザイモジェネティクス, インコーポレイテッド |
Il−31raアンタゴニストおよびosmrbアンタゴニストを用いて神経組織における疼痛および炎症を治療する方法
|
US8075884B2
(en)
*
|
2006-01-12 |
2011-12-13 |
Alexion Pharmaceuticals, Inc. |
Antibodies to OX-2/CD200 and uses thereof
|
ES2685915T3
(es)
|
2006-01-27 |
2018-10-15 |
Keio University |
Agentes terapéuticos para enfermedades que implican neovascularización coroidea
|
CA2644663A1
(en)
*
|
2006-03-23 |
2007-09-27 |
Kirin Pharma Kabushiki Kaisha |
Agonist antibody to human thrombopoietin receptor
|
JP5033868B2
(ja)
|
2006-03-23 |
2012-09-26 |
バイオアークティック ニューロサイエンス アーベー |
改良型プロトフィブリル選択的抗体及びその使用
|
EP4342995A3
(en)
|
2006-03-31 |
2024-05-15 |
Chugai Seiyaku Kabushiki Kaisha |
Methods for controlling blood pharmacokinetics of antibodies
|
US9670269B2
(en)
|
2006-03-31 |
2017-06-06 |
Chugai Seiyaku Kabushiki Kaisha |
Methods of modifying antibodies for purification of bispecific antibodies
|
CN101495146B
(zh)
|
2006-04-07 |
2012-10-17 |
国立大学法人大阪大学 |
肌肉再生促进剂
|
WO2007134050A2
(en)
|
2006-05-09 |
2007-11-22 |
Genentech, Inc. |
Binding polypeptides with optimized scaffolds
|
ES2514495T3
(es)
|
2006-05-25 |
2014-10-28 |
Glaxo Group Limited |
Anticuerpos humanizados modificados anti-interleucina-18
|
US8080248B2
(en)
|
2006-06-02 |
2011-12-20 |
Regeneron Pharmaceuticals, Inc. |
Method of treating rheumatoid arthritis with an IL-6R antibody
|
US7582298B2
(en)
|
2006-06-02 |
2009-09-01 |
Regeneron Pharmaceuticals, Inc. |
High affinity antibodies to human IL-6 receptor
|
UA100116C2
(ru)
|
2006-06-08 |
2012-11-26 |
Чугей Сейяку Кабусики Кайся |
Профилактика или лечение воспалительного заболевания
|
EP2032602B1
(en)
*
|
2006-06-15 |
2013-03-27 |
The Board of Trustees of the University of Arkansas |
Monoclonal antibodies that selectively recognize methamphetamine and methamphetamine like compounds
|
SI2059536T1
(sl)
|
2006-08-14 |
2014-06-30 |
Xencor, Inc. |
Optimirana protitelesa, ki ciljajo CD19
|
EP2059533B1
(en)
|
2006-08-30 |
2012-11-14 |
Genentech, Inc. |
Multispecific antibodies
|
US20100034194A1
(en)
|
2006-10-11 |
2010-02-11 |
Siemens Communications Inc. |
Eliminating unreachable subscribers in voice-over-ip networks
|
US20080226635A1
(en)
|
2006-12-22 |
2008-09-18 |
Hans Koll |
Antibodies against insulin-like growth factor I receptor and uses thereof
|
TWI438208B
(zh)
|
2007-01-23 |
2014-05-21 |
Chugai Pharmaceutical Co Ltd |
抑制慢性排斥反應之藥劑
|
US20110236374A1
(en)
*
|
2007-01-24 |
2011-09-29 |
Kyowa Hakko Kirin Co., Ltd. |
Genetically recombinant antibody composition capable of binding specifically to ganglioside gm2
|
WO2008092117A2
(en)
|
2007-01-25 |
2008-07-31 |
Xencor, Inc. |
Immunoglobulins with modifications in the fcr binding region
|
EP2069404B1
(en)
*
|
2007-02-14 |
2011-01-05 |
Vaccinex, Inc. |
Humanized anti-cd100 antibodies
|
TR201821029T4
(tr)
|
2007-02-23 |
2019-01-21 |
Merck Sharp & Dohme |
Geliştirilmiş antı-IL-23p19 antikorları.
|
WO2008114733A1
(ja)
|
2007-03-16 |
2008-09-25 |
Kyowa Hakko Kirin Co., Ltd. |
抗Claudin-4抗体
|
CA2681974C
(en)
|
2007-03-29 |
2019-12-31 |
Genmab A/S |
Bispecific antibodies and methods for production thereof
|
GB0708002D0
(en)
|
2007-04-25 |
2007-06-06 |
Univ Sheffield |
Antibodies
|
CN100592373C
(zh)
|
2007-05-25 |
2010-02-24 |
群康科技(深圳)有限公司 |
液晶显示面板驱动装置及其驱动方法
|
WO2008145141A1
(en)
|
2007-05-31 |
2008-12-04 |
Genmab A/S |
Method for extending the half-life of exogenous or endogenous soluble molecules
|
JP6071165B2
(ja)
|
2007-05-31 |
2017-02-01 |
ゲンマブ エー/エス |
安定なIgG4抗体
|
EP3246045A1
(en)
|
2007-07-26 |
2017-11-22 |
Osaka University |
Therapeutic agents for ocular inflammatory disease comprising interleukin 6 receptor inhibitor as active ingredient
|
EP2031064A1
(de)
*
|
2007-08-29 |
2009-03-04 |
Boehringer Ingelheim Pharma GmbH & Co. KG |
Verfahren zur Steigerung von Proteintitern
|
EP2197911A2
(en)
*
|
2007-09-14 |
2010-06-23 |
Amgen Inc. |
Homogeneous antibody populations
|
DK2202245T3
(en)
|
2007-09-26 |
2016-11-21 |
Chugai Pharmaceutical Co Ltd |
A method of modifying an antibody isoelectric point VIA amino acid substitution in CDR
|
WO2009041734A1
(ja)
|
2007-09-26 |
2009-04-02 |
Kyowa Hakko Kirin Co., Ltd. |
ヒトトロンボポエチン受容体に対するアゴニスト抗体
|
WO2009041613A1
(ja)
|
2007-09-26 |
2009-04-02 |
Chugai Seiyaku Kabushiki Kaisha |
抗体定常領域改変体
|
WO2009041621A1
(ja)
|
2007-09-26 |
2009-04-02 |
Chugai Seiyaku Kabushiki Kaisha |
抗il-6レセプター抗体
|
AR066172A1
(es)
|
2007-09-28 |
2009-07-29 |
Chugai Pharmaceutical Co Ltd |
Metodo para la preparacion de un anticuerpo antiglipicano 3 con modulada cinetica plasmatica mediante variacion de la semivida plasmatica.
|
CA2701155C
(en)
|
2007-10-02 |
2016-11-22 |
Chugai Seiyaku Kabushiki Kaisha |
Therapeutic agents for graft-versus-host disease comprising interleukin 6 receptor inhibitor as active ingredient
|
JO3076B1
(ar)
|
2007-10-17 |
2017-03-15 |
Janssen Alzheimer Immunotherap |
نظم العلاج المناعي المعتمد على حالة apoe
|
EP2203180B1
(en)
|
2007-10-22 |
2012-11-21 |
Merck Serono S.A. |
Single ifn-beta fused to a mutated igg fc fragment
|
EP2853544A1
(en)
*
|
2007-11-15 |
2015-04-01 |
Chugai Seiyaku Kabushiki Kaisha |
Monoclonal antibody capable of binding to anexelekto, and use thereof
|
EP2241332A4
(en)
|
2007-12-05 |
2011-01-26 |
Chugai Pharmaceutical Co Ltd |
THERAPEUTIC AGENT AGAINST PRITURE
|
KR101840994B1
(ko)
|
2007-12-05 |
2018-03-21 |
추가이 세이야쿠 가부시키가이샤 |
항nr10 항체 및 그의 이용
|
CN101918448A
(zh)
|
2007-12-18 |
2010-12-15 |
生物联合公司 |
识别癌细胞上表达的cd-43和cea的含糖表位的抗体及其使用方法
|
CA3086659A1
(en)
|
2007-12-26 |
2009-07-09 |
Xencor, Inc. |
Fc variants with altered binding to fcrn
|
EP3663318A1
(en)
|
2008-01-07 |
2020-06-10 |
Amgen Inc. |
Method for making antibody fc-heterodimeric molecules using electrostatic steering effects
|
DK2250279T3
(en)
|
2008-02-08 |
2016-08-01 |
Medimmune Llc |
ANTI-IFNAR1 antibodies with reduced Fc ligand affinity-
|
EP3056513A1
(en)
*
|
2008-04-11 |
2016-08-17 |
Chugai Seiyaku Kabushiki Kaisha |
Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
|
JP2011519279A
(ja)
|
2008-05-01 |
2011-07-07 |
アムジエン・インコーポレーテツド |
抗ヘプシジン抗体及び使用の方法
|
TW201503898A
(zh)
|
2008-06-05 |
2015-02-01 |
Chugai Pharmaceutical Co Ltd |
神經浸潤抑制劑
|
TWI440469B
(zh)
|
2008-09-26 |
2014-06-11 |
Chugai Pharmaceutical Co Ltd |
Improved antibody molecules
|
CA2739551C
(en)
|
2008-10-13 |
2019-03-05 |
Institute For Research In Biomedicine |
Dengue virus neutralizing antibodies and uses thereof
|
RU2536937C2
(ru)
|
2008-10-14 |
2014-12-27 |
Дженентек, Инк. |
Варианты иммуноглобулина и их применения
|
CN102438653B
(zh)
|
2008-11-25 |
2019-04-23 |
奥尔德生物制药公司 |
预防或治疗恶病质、虚弱、疲劳和/或发烧il-6拮抗剂
|
AR074438A1
(es)
|
2008-12-02 |
2011-01-19 |
Pf Medicament |
Proceso para la modulacion de la actividad antagonista de un anticuerpo monoclonal
|
WO2010064090A1
(en)
|
2008-12-02 |
2010-06-10 |
Pierre Fabre Medicament |
Process for the modulation of the antagonistic activity of a monoclonal antibody
|
KR20160062207A
(ko)
|
2008-12-05 |
2016-06-01 |
추가이 세이야쿠 가부시키가이샤 |
항nr10 항체 및 그의 이용
|
WO2010080065A1
(en)
|
2009-01-12 |
2010-07-15 |
Ge Healthcare Bio-Sciences Ab |
Affinity chromatography matrix
|
JP2010210772A
(ja)
|
2009-03-13 |
2010-09-24 |
Dainippon Screen Mfg Co Ltd |
液晶表示装置の製造方法
|
TWI544077B
(zh)
|
2009-03-19 |
2016-08-01 |
Chugai Pharmaceutical Co Ltd |
Antibody constant region change body
|
US9228017B2
(en)
*
|
2009-03-19 |
2016-01-05 |
Chugai Seiyaku Kabushiki Kaisha |
Antibody constant region variant
|
EP2233500A1
(en)
|
2009-03-20 |
2010-09-29 |
LFB Biotechnologies |
Optimized Fc variants
|
BRPI1010297A2
(pt)
|
2009-04-07 |
2017-06-06 |
Roche Glycart Ag |
anticorpos biespecíficos trivalentes.
|
US9340615B2
(en)
*
|
2009-05-15 |
2016-05-17 |
Chugai Seiyaku Kabushiki Kaisha |
Anti-AXL antibody
|
EP2445936A1
(en)
|
2009-06-26 |
2012-05-02 |
Regeneron Pharmaceuticals, Inc. |
Readily isolated bispecific antibodies with native immunoglobulin format
|
US10150808B2
(en)
*
|
2009-09-24 |
2018-12-11 |
Chugai Seiyaku Kabushiki Kaisha |
Modified antibody constant regions
|
WO2011074904A2
(ko)
|
2009-12-18 |
2011-06-23 |
한국전자통신연구원 |
여러 단말과 동시에 통신하는 무선 패킷 통신 시스템에서 데이터 송/수신 방법
|
KR101856792B1
(ko)
|
2009-12-25 |
2018-05-11 |
추가이 세이야쿠 가부시키가이샤 |
폴리펩티드 다량체를 정제하기 위한 폴리펩티드의 개변방법
|
CN102958942A
(zh)
|
2009-12-29 |
2013-03-06 |
新兴产品开发西雅图有限公司 |
异二聚体结合蛋白及其应用
|
US8362210B2
(en)
|
2010-01-19 |
2013-01-29 |
Xencor, Inc. |
Antibody variants with enhanced complement activity
|
US9023997B2
(en)
|
2010-01-20 |
2015-05-05 |
Merck Sharp & Dohme Corp. |
Anti-ILT5 antibodies and ILT5-binding antibody fragments
|
JP5947727B2
(ja)
|
2010-01-20 |
2016-07-06 |
メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. |
抗ilt5抗体およびilt5結合抗体断片による免疫調節
|
CA2791652C
(en)
|
2010-03-02 |
2018-06-12 |
Kyowa Hakko Kirin Co., Ltd. |
Modified antibody composition
|
WO2011108714A1
(ja)
|
2010-03-04 |
2011-09-09 |
中外製薬株式会社 |
抗体定常領域改変体
|
BR112012022917A2
(pt)
|
2010-03-11 |
2017-01-10 |
Pfizer |
anticorpos com ligação a antígeno dependente de ph
|
TWI667346B
(zh)
|
2010-03-30 |
2019-08-01 |
中外製藥股份有限公司 |
促進抗原消失之具有經修飾的FcRn親和力之抗體
|
KR20130018256A
(ko)
|
2010-03-31 |
2013-02-20 |
제이에스알 가부시끼가이샤 |
친화성 크로마토그래피용 충전제
|
US9150663B2
(en)
|
2010-04-20 |
2015-10-06 |
Genmab A/S |
Heterodimeric antibody Fc-containing proteins and methods for production thereof
|
CA2796633C
(en)
|
2010-04-23 |
2020-10-27 |
Genentech, Inc. |
Production of heteromultimeric proteins
|
US9527926B2
(en)
|
2010-05-14 |
2016-12-27 |
Rinat Neuroscience Corp. |
Heterodimeric proteins and methods for producing and purifying them
|
WO2011149046A1
(ja)
|
2010-05-28 |
2011-12-01 |
独立行政法人国立がん研究センター |
膵癌治療剤
|
CN103052649B
(zh)
|
2010-07-29 |
2015-12-16 |
Xencor公司 |
具有修改的等电点的抗体
|
JP2013537416A
(ja)
|
2010-08-13 |
2013-10-03 |
メディミューン リミテッド |
変異型Fc領域を含むモノマーポリペプチド及び使用方法
|
RU2604490C2
(ru)
|
2010-11-05 |
2016-12-10 |
Займворкс Инк. |
ДИЗАЙН УСТОЙЧИВОГО ГЕТЕРОДИМЕРНОГО АНТИТЕЛА С МУТАЦИЯМИ В Fc ДОМЕНЕ
|
KR20210021109A
(ko)
|
2010-11-08 |
2021-02-24 |
제넨테크, 인크. |
피하 투여용 항―il―6 수용체 항체
|
BR112013012213A2
(pt)
|
2010-11-17 |
2020-09-01 |
Chugai Seiyaku Kabushiki Kaisha |
moléculas de ligação a antígeno mul tlespecíficas tendo função alternativa à função dos fatores viii, ix e x de coagulação sanguínea, e anticorpo bies- 5 pecífico, seus usos na prevenção ou tratamento de hemorragia, ácido nucleico, vetor, célula, método para produzir as referidas moléculas de ligação, composição farmacêutica e kit
|
RU2658504C9
(ru)
|
2010-11-30 |
2018-08-21 |
Чугаи Сейяку Кабусики Кайся |
Антигенсвязывающая молекула, способная многократно связываться с множеством антигенных молекул
|
TWI807362B
(zh)
|
2010-11-30 |
2023-07-01 |
日商中外製藥股份有限公司 |
細胞傷害誘導治療劑
|
WO2012082073A1
(en)
|
2010-12-14 |
2012-06-21 |
National University Of Singapore |
Human monoclonal antibody with specificity for dengue virus serotype 1 e protein and uses thereof
|
WO2012132067A1
(ja)
|
2011-03-30 |
2012-10-04 |
中外製薬株式会社 |
抗原結合分子の血漿中滞留性と免疫原性を改変する方法
|
EP2699263A4
(en)
|
2011-04-20 |
2014-12-24 |
Liquidating Trust |
METHOD FOR REDUCING AN UNWANTED IMMUNE RESPONSE TO A FOREIGN-LIKE IN A HUMAN PATIENT WITH ANTI-CD4 ANTIBODIES OR CD4-BINDING FRAGMENTS THEREOF OR CD4-BINDING MOLECULES
|
JP5729817B2
(ja)
|
2011-06-29 |
2015-06-03 |
日本電信電話株式会社 |
動画像符号化装置、動画像復号装置、動画像符号化方法、動画像復号方法、動画像符号化プログラム及び動画像復号プログラム
|
CA3186128A1
(en)
|
2011-09-30 |
2013-04-04 |
Chugai Seiyaku Kabushiki Kaisha |
Antigen-binding molecule for promoting elimination of antigens
|
TW201817744A
(zh)
|
2011-09-30 |
2018-05-16 |
日商中外製藥股份有限公司 |
具有促進抗原清除之FcRn結合域的治療性抗原結合分子
|
PT2771364T
(pt)
|
2011-10-27 |
2019-09-10 |
Genmab As |
Produção de proteínas heterodiméricas
|
KR102052774B1
(ko)
|
2011-11-04 |
2019-12-04 |
자임워크스 인코포레이티드 |
Fc 도메인 내의 돌연변이를 갖는 안정한 이종이합체 항체 설계
|
US20140349321A1
(en)
|
2011-12-16 |
2014-11-27 |
Agency For Science, Technology And Research |
Binding molecules against dengue virus and uses thereof
|
GB201203051D0
(en)
|
2012-02-22 |
2012-04-04 |
Ucb Pharma Sa |
Biological products
|
EP3517548A1
(en)
|
2012-03-13 |
2019-07-31 |
NovImmune S.A. |
Readily isolated bispecific antibodies with native immunoglobulin format
|
EP2832856A4
(en)
|
2012-03-29 |
2016-01-27 |
Chugai Pharmaceutical Co Ltd |
ANTI-LAMP5 ANTIBODIES AND USE THEREOF
|
WO2013151764A1
(en)
|
2012-04-02 |
2013-10-10 |
The University Of North Carolina At Chapel Hill |
Methods and compositions for dengue virus epitopes
|
PT2838918T
(pt)
|
2012-04-20 |
2019-08-23 |
Merus Nv |
Métodos e meios para a produção de moléculas heterrodiméricas do tipo ig
|
US9556254B2
(en)
|
2012-05-14 |
2017-01-31 |
The Usa, As Represented By The Secretary, Dept. Of Health And Human Services |
Cross-reactive antibodies against dengue virus and uses thereof
|
US20140154270A1
(en)
|
2012-05-21 |
2014-06-05 |
Chen Wang |
Purification of non-human antibodies using kosmotropic salt enhanced protein a affinity chromatography
|
DK2857420T3
(da)
|
2012-05-30 |
2020-11-23 |
Chugai Pharmaceutical Co Ltd |
Målvævsspecifikt antigenbindende molekyle
|
WO2013180201A1
(ja)
|
2012-05-30 |
2013-12-05 |
中外製薬株式会社 |
会合化した抗原を消失させる抗原結合分子
|
CA2879994C
(en)
|
2012-08-07 |
2023-03-21 |
Massachusetts Institute Of Technology |
Anti-dengue virus antibodies and uses thereof
|
WO2014028354A1
(en)
|
2012-08-13 |
2014-02-20 |
Regeneron Pharmaceuticals, Inc. |
Anti-pcsk9 antibodies with ph-dependent binding characteristics
|
WO2014038686A1
(ja)
|
2012-09-10 |
2014-03-13 |
株式会社カネカ |
吸着体
|
WO2014054804A1
(ja)
|
2012-10-05 |
2014-04-10 |
協和発酵キリン株式会社 |
ヘテロダイマータンパク質組成物
|
EP2914634B1
(en)
|
2012-11-02 |
2017-12-06 |
Zymeworks Inc. |
Crystal structures of heterodimeric fc domains
|
CN105143257B
(zh)
|
2013-03-15 |
2020-10-27 |
艾伯维生物医疗股份有限公司 |
Fc变体
|
WO2014145159A2
(en)
|
2013-03-15 |
2014-09-18 |
Permeon Biologics, Inc. |
Charge-engineered antibodies or compositions of penetration-enhanced targeting proteins and methods of use
|
JP6534615B2
(ja)
|
2013-09-27 |
2019-06-26 |
中外製薬株式会社 |
ポリペプチド異種多量体の製造方法
|
WO2015063339A1
(en)
|
2013-11-04 |
2015-05-07 |
Glenmark Pharmaceuticals S.A. |
Production of t cell retargeting hetero-dimeric immunoglobulins
|
CN106413749B
(zh)
|
2014-02-11 |
2022-04-05 |
麻省理工学院 |
新颖全谱抗登革抗体
|
AU2015217572B2
(en)
|
2014-02-11 |
2020-10-15 |
Visterra, Inc. |
Antibody moleules to dengue virus and uses thereof
|
GB201413086D0
(en)
|
2014-07-23 |
2014-09-03 |
Imp Innovations Ltd And Inst Pasteur |
Methods
|
AR101262A1
(es)
|
2014-07-26 |
2016-12-07 |
Regeneron Pharma |
Plataforma de purificación para anticuerpos biespecíficos
|
JP6630036B2
(ja)
|
2014-09-30 |
2020-01-15 |
Jsr株式会社 |
標的物の精製方法、及び、ミックスモード用担体
|
KR20180054923A
(ko)
|
2014-12-19 |
2018-05-24 |
추가이 세이야쿠 가부시키가이샤 |
항-마이오스타틴 항체, 변이체 Fc 영역을 함유하는 폴리펩타이드, 및 사용 방법
|
EP3816179A3
(en)
|
2015-02-05 |
2021-08-04 |
Chugai Seiyaku Kabushiki Kaisha |
Fc region variant comprising a modified fcrn-binding domain
|
SG11201705093UA
(en)
|
2015-02-27 |
2017-07-28 |
Chugai Pharmaceutical Co Ltd |
Composition for treating il-6-related diseases
|
JP7082484B2
(ja)
|
2015-04-01 |
2022-06-08 |
中外製薬株式会社 |
ポリペプチド異種多量体の製造方法
|
CN108368166B
(zh)
|
2015-12-28 |
2023-03-28 |
中外制药株式会社 |
提高含fc区多肽纯化效率的方法
|
GB201610162D0
(en)
|
2016-06-10 |
2016-07-27 |
Imp Innovations Ltd And Inst Pasteur |
Methods
|
SG10201607778XA
(en)
|
2016-09-16 |
2018-04-27 |
Chugai Pharmaceutical Co Ltd |
Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use
|
SG11202009010RA
(en)
|
2018-03-15 |
2020-10-29 |
Chugai Pharmaceutical Co Ltd |
Anti-dengue virus antibodies having cross-reactivity to zika virus and methods of use
|