JPH11508232A - モノマー性カリキアミシン誘導体／キャリアー複合体の調製方法 - Google Patents
モノマー性カリキアミシン誘導体／キャリアー複合体の調製方法Info
- Publication number
- JPH11508232A JPH11508232A JP9500547A JP50054797A JPH11508232A JP H11508232 A JPH11508232 A JP H11508232A JP 9500547 A JP9500547 A JP 9500547A JP 50054797 A JP50054797 A JP 50054797A JP H11508232 A JPH11508232 A JP H11508232A
- Authority
- JP
- Japan
- Prior art keywords
- coor
- group
- alkyl
- conhr
- trivalent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6881—Cluster-antibody conjugates, i.e. the modifying agent consists of a plurality of antibodies covalently linked to each other or of different antigen-binding fragments covalently linked to each other
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
- A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/475,005 | 1995-06-07 | ||
| US08/475,005 US5712374A (en) | 1995-06-07 | 1995-06-07 | Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates |
| PCT/US1996/006738 WO1996040261A1 (en) | 1995-06-07 | 1996-05-10 | Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008230053A Division JP2009073832A (ja) | 1995-06-07 | 2008-09-08 | モノマー性カリキアミシン誘導体／キャリアー複合体の製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH11508232A true JPH11508232A (ja) | 1999-07-21 |
Family
ID=23885856
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9500547A Pending JPH11508232A (ja) | 1995-06-07 | 1996-05-10 | モノマー性カリキアミシン誘導体／キャリアー複合体の調製方法 |
| JP2008230053A Pending JP2009073832A (ja) | 1995-06-07 | 2008-09-08 | モノマー性カリキアミシン誘導体／キャリアー複合体の製造方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008230053A Pending JP2009073832A (ja) | 1995-06-07 | 2008-09-08 | モノマー性カリキアミシン誘導体／キャリアー複合体の製造方法 |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US5712374A (enExample) |
| EP (1) | EP0837698B1 (enExample) |
| JP (2) | JPH11508232A (enExample) |
| KR (1) | KR100499648B1 (enExample) |
| CN (1) | CN1094063C (enExample) |
| AR (1) | AR002360A1 (enExample) |
| AT (1) | ATE204180T1 (enExample) |
| AU (1) | AU703862B2 (enExample) |
| BG (1) | BG63492B1 (enExample) |
| BR (1) | BR9608564A (enExample) |
| CA (1) | CA2223329A1 (enExample) |
| CY (1) | CY2355B1 (enExample) |
| CZ (1) | CZ298024B6 (enExample) |
| DE (1) | DE69614551T2 (enExample) |
| DK (1) | DK0837698T3 (enExample) |
| ES (1) | ES2160818T3 (enExample) |
| GR (1) | GR3036930T3 (enExample) |
| HU (1) | HU221246B1 (enExample) |
| IL (1) | IL118565A (enExample) |
| IN (1) | IN182139B (enExample) |
| MX (1) | MX9709316A (enExample) |
| NO (1) | NO324609B1 (enExample) |
| NZ (1) | NZ307926A (enExample) |
| PT (1) | PT837698E (enExample) |
| PY (1) | PY0101651A (enExample) |
| TW (1) | TW419377B (enExample) |
| WO (1) | WO1996040261A1 (enExample) |
| ZA (1) | ZA964614B (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005524700A (ja) * | 2002-05-02 | 2005-08-18 | ワイス・ホールディングズ・コーポレイション | カリチェアミシン誘導体−キャリアコンジュゲート |
| JP2009500623A (ja) * | 2005-07-01 | 2009-01-08 | ワイス | 標的治療薬の薬物動態特性の測定方法 |
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| ES2637801T3 (es) | 2000-04-11 | 2017-10-17 | Genentech, Inc. | Anticuerpos multivalentes y usos de los mismos |
| US7129261B2 (en) * | 2001-05-31 | 2006-10-31 | Medarex, Inc. | Cytotoxic agents |
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1996
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- 1996-05-10 MX MX9709316A patent/MX9709316A/es not_active IP Right Cessation
- 1996-05-10 CN CN96194451A patent/CN1094063C/zh not_active Expired - Fee Related
- 1996-05-10 HU HU9901351A patent/HU221246B1/hu not_active IP Right Cessation
- 1996-05-10 JP JP9500547A patent/JPH11508232A/ja active Pending
- 1996-05-10 KR KR1019970708934A patent/KR100499648B1/ko not_active Expired - Fee Related
- 1996-05-10 CZ CZ0393997A patent/CZ298024B6/cs not_active IP Right Cessation
- 1996-05-10 EP EP96915718A patent/EP0837698B1/en not_active Expired - Lifetime
- 1996-05-10 WO PCT/US1996/006738 patent/WO1996040261A1/en not_active Ceased
- 1996-05-10 ES ES96915718T patent/ES2160818T3/es not_active Expired - Lifetime
- 1996-05-10 DE DE69614551T patent/DE69614551T2/de not_active Expired - Fee Related
- 1996-05-10 CA CA002223329A patent/CA2223329A1/en not_active Abandoned
- 1996-05-10 PT PT96915718T patent/PT837698E/pt unknown
- 1996-05-10 NZ NZ307926A patent/NZ307926A/en not_active IP Right Cessation
- 1996-05-10 DK DK96915718T patent/DK0837698T3/da active
- 1996-05-10 AU AU57423/96A patent/AU703862B2/en not_active Ceased
- 1996-05-10 AT AT96915718T patent/ATE204180T1/de not_active IP Right Cessation
- 1996-06-04 IN IN1032CA1996 patent/IN182139B/en unknown
- 1996-06-04 ZA ZA9604614A patent/ZA964614B/xx unknown
- 1996-06-04 IL IL11856596A patent/IL118565A/en not_active IP Right Cessation
- 1996-06-06 AR ARP960102996A patent/AR002360A1/es active IP Right Grant
- 1996-07-19 TW TW085108822A patent/TW419377B/zh not_active IP Right Cessation
-
1997
- 1997-12-03 BG BG102100A patent/BG63492B1/bg unknown
- 1997-12-05 NO NO19975706A patent/NO324609B1/no not_active IP Right Cessation
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2001
- 2001-01-26 PY PY200100101651A patent/PY0101651A/es unknown
- 2001-10-18 GR GR20010401797T patent/GR3036930T3/el not_active IP Right Cessation
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2003
- 2003-01-22 CY CY0300018A patent/CY2355B1/xx unknown
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2008
- 2008-09-08 JP JP2008230053A patent/JP2009073832A/ja active Pending
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005524700A (ja) * | 2002-05-02 | 2005-08-18 | ワイス・ホールディングズ・コーポレイション | カリチェアミシン誘導体−キャリアコンジュゲート |
| JP2012051900A (ja) * | 2002-05-02 | 2012-03-15 | Wyeth Holdings Corp | カリチェアミシン誘導体−キャリアコンジュゲート |
| US8153768B2 (en) | 2002-05-02 | 2012-04-10 | Wyeth Holdings Corporation | Calicheamicin derivative-carrier conjugates |
| JP2013163678A (ja) * | 2002-05-02 | 2013-08-22 | Wyeth Holdings Corp | カリチェアミシン誘導体−キャリアコンジュゲート |
| US8747857B2 (en) | 2002-05-02 | 2014-06-10 | Wyeth Holdings Llc | Calicheamicin derivative-carrier conjugates |
| US8835611B2 (en) | 2002-05-02 | 2014-09-16 | Wyeth Holdings Llc | Calicheamicin derivative-carrier conjugates |
| JP2015061875A (ja) * | 2002-05-02 | 2015-04-02 | ワイス・ホールディングズ・コーポレイション | カリチェアミシン誘導体−キャリアコンジュゲート |
| US9351986B2 (en) | 2002-05-02 | 2016-05-31 | Wyeth Holdings Llc | Calicheamicin derivative-carrier conjugates |
| JP2017105801A (ja) * | 2002-05-02 | 2017-06-15 | ワイス・ホールディングズ・コーポレイション | カリチェアミシン誘導体−キャリアコンジュゲート |
| JP2009500623A (ja) * | 2005-07-01 | 2009-01-08 | ワイス | 標的治療薬の薬物動態特性の測定方法 |
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