JP7054622B2 - ヒト化抗ｂｃｍａキメラ抗原受容体を使用した癌の処置 - Google Patents

ヒト化抗ｂｃｍａキメラ抗原受容体を使用した癌の処置 Download PDF

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JP7054622B2
JP7054622B2 JP2017503498A JP2017503498A JP7054622B2 JP 7054622 B2 JP7054622 B2 JP 7054622B2 JP 2017503498 A JP2017503498 A JP 2017503498A JP 2017503498 A JP2017503498 A JP 2017503498A JP 7054622 B2 JP7054622 B2 JP 7054622B2
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amino acid
acid sequence
bcma
cells
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JP2017527271A5 (enExample
JP2017527271A (ja
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ジェニファー・ブログドン
ユージーン・チェ
ヒルマー・エーバースバッハ
デイビッド・グラス
ヘザー・ヒュエ
カール・エイチ・ジューン
ジョアン・マニック
マイケル・シー・ミローン
レオン・マーフィー
ガブリエラ・プレサ
セレスト・リチャードソン
マルコ・ルエラ
ラシュマ・シン
ワン・ヨンチアン
チーロン・ウー
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ノバルティス アーゲー
ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • A61K35/14—Blood; Artificial blood
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    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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JP2017503498A 2014-07-21 2015-07-21 ヒト化抗ｂｃｍａキメラ抗原受容体を使用した癌の処置 Active JP7054622B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN2014082586 2014-07-21
CNPCT/CN2014/082586 2014-07-21
CNPCT/CN2014/090501 2014-11-06
CN2014090501 2014-11-06
PCT/US2015/041378 WO2016014565A2 (en) 2014-07-21 2015-07-21 Treatment of cancer using humanized anti-bcma chimeric antigen receptor

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JP2017527271A JP2017527271A (ja) 2017-09-21
JP2017527271A5 JP2017527271A5 (enExample) 2018-08-30
JP7054622B2 true JP7054622B2 (ja) 2022-04-14

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JP2020167201A Pending JP2021019610A (ja) 2014-07-21 2020-10-01 ヒト化抗ｂｃｍａキメラ抗原受容体を使用した癌の処置

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US (3) US10174095B2 (enExample)
EP (1) EP3172237A2 (enExample)
JP (2) JP7054622B2 (enExample)
KR (1) KR102612313B1 (enExample)
CN (1) CN106687483B (enExample)
AU (2) AU2015292744C1 (enExample)
BR (1) BR112017001183A2 (enExample)
CO (1) CO2017000507A2 (enExample)
IL (1) IL250043B (enExample)
MX (1) MX2017001011A (enExample)
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RU (1) RU2751660C2 (enExample)
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WO2014130635A1 (en) 2013-02-20 2014-08-28 Novartis Ag Effective targeting of primary human leukemia using anti-cd123 chimeric antigen receptor engineered t cells
EP2958943B1 (en) 2013-02-20 2019-09-11 The Trustees Of The University Of Pennsylvania Treatment of cancer using humanized anti-egfrviii chimeric antigen receptor
US9745368B2 (en) * 2013-03-15 2017-08-29 The Trustees Of The University Of Pennsylvania Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
TWI654206B (zh) 2013-03-16 2019-03-21 諾華公司 使用人類化抗－ｃｄ１９嵌合抗原受體治療癌症
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US9737604B2 (en) 2013-09-06 2017-08-22 President And Fellows Of Harvard College Use of cationic lipids to deliver CAS9
US9388430B2 (en) 2013-09-06 2016-07-12 President And Fellows Of Harvard College Cas9-recombinase fusion proteins and uses thereof
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US11028143B2 (en) 2014-01-21 2021-06-08 Novartis Ag Enhanced antigen presenting ability of RNA CAR T cells by co-introduction of costimulatory molecules
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JP6698546B2 (ja) 2014-04-14 2020-05-27 セレクティスＣｅｌｌｅｃｔｉｓ 癌免疫療法のためのｂｃｍａ（ｃｄ２６９）特異的キメラ抗原受容体
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BR112017001183A2 (pt) 2014-07-21 2017-11-28 Novartis Ag tratamento de câncer usando receptor de antígeno quimérico anti-bcma humanizado
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