SG11201803419PA - Methods of generating t-cells from stem cells and immunotherapeutic methods using the t-cells - Google Patents

Methods of generating t-cells from stem cells and immunotherapeutic methods using the t-cells

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Publication number
SG11201803419PA
SG11201803419PA SG11201803419PA SG11201803419PA SG11201803419PA SG 11201803419P A SG11201803419P A SG 11201803419PA SG 11201803419P A SG11201803419P A SG 11201803419PA SG 11201803419P A SG11201803419P A SG 11201803419PA SG 11201803419P A SG11201803419P A SG 11201803419PA
Authority
SG
Singapore
Prior art keywords
cells
methods
generating
immunotherapeutic
stem
Prior art date
Application number
SG11201803419PA
Inventor
Gay Crooks
Amelie Hagen
Christopher Seet
Original Assignee
The Regents Of The Universtiy Of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Regents Of The Universtiy Of California filed Critical The Regents Of The Universtiy Of California
Publication of SG11201803419PA publication Critical patent/SG11201803419PA/en

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/463—Cellular immunotherapy characterised by recombinant expression
    • A61K39/4631—Chimeric Antigen Receptors [CAR]
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/463—Cellular immunotherapy characterised by recombinant expression
    • A61K39/4632—T-cell receptors [TCR]; antibody T-cell receptor constructs
    • A—HUMAN NECESSITIES
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    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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    • C07K2319/00—Fusion polypeptide
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SG11201803419PA 2015-10-30 2016-10-28 Methods of generating t-cells from stem cells and immunotherapeutic methods using the t-cells SG11201803419PA (en)

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US201562248931P 2015-10-30 2015-10-30
US201562265204P 2015-12-09 2015-12-09
US201662359456P 2016-07-07 2016-07-07
PCT/US2016/059375 WO2017075389A1 (en) 2015-10-30 2016-10-28 Methods of generating t-cells from stem cells and immunotherapeutic methods using the t-cells

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EP (1) EP3368660A4 (en)
JP (2) JP6983771B2 (en)
KR (1) KR20180092951A (en)
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AU (2) AU2016343682A1 (en)
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