MY181834A - Treatment of cancer using humanized anti-bcma chimeric antigen receptor - Google Patents

Treatment of cancer using humanized anti-bcma chimeric antigen receptor

Info

Publication number
MY181834A
MY181834A MYPI2017700118A MYPI2017700118A MY181834A MY 181834 A MY181834 A MY 181834A MY PI2017700118 A MYPI2017700118 A MY PI2017700118A MY PI2017700118 A MYPI2017700118 A MY PI2017700118A MY 181834 A MY181834 A MY 181834A
Authority
MY
Malaysia
Prior art keywords
bcma
antigen receptor
chimeric antigen
cancer
treatment
Prior art date
Application number
MYPI2017700118A
Other languages
English (en)
Inventor
Jennifer Brogdon
Eugene Choi
Hilmar Ebersbach
David Glass
Heather Huet
Carl H June
Joan Mannick
Michael C Milone
Leon Murphy
Gabriela Plesa
Celeste Richardson
Marco Ruella
Reshma Singh
Yongqiang Wang
Qilong Wu
Original Assignee
Novartis Ag
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Univ Pennsylvania filed Critical Novartis Ag
Publication of MY181834A publication Critical patent/MY181834A/en

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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
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    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
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    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N5/0602—Vertebrate cells
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
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    • C07K2317/622—Single chain antibody (scFv)
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MYPI2017700118A 2014-07-21 2015-07-21 Treatment of cancer using humanized anti-bcma chimeric antigen receptor MY181834A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2014082586 2014-07-21
CN2014090501 2014-11-06
PCT/US2015/041378 WO2016014565A2 (en) 2014-07-21 2015-07-21 Treatment of cancer using humanized anti-bcma chimeric antigen receptor

Publications (1)

Publication Number Publication Date
MY181834A true MY181834A (en) 2021-01-08

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Application Number Title Priority Date Filing Date
MYPI2017700118A MY181834A (en) 2014-07-21 2015-07-21 Treatment of cancer using humanized anti-bcma chimeric antigen receptor

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Country Link
US (3) US10174095B2 (enExample)
EP (1) EP3172237A2 (enExample)
JP (2) JP7054622B2 (enExample)
KR (1) KR102612313B1 (enExample)
CN (1) CN106687483B (enExample)
AU (2) AU2015292744C1 (enExample)
BR (1) BR112017001183A2 (enExample)
CO (1) CO2017000507A2 (enExample)
IL (1) IL250043B (enExample)
MX (1) MX2017001011A (enExample)
MY (1) MY181834A (enExample)
RU (1) RU2751660C2 (enExample)
SG (1) SG11201700476VA (enExample)
TW (1) TWI750110B (enExample)
WO (1) WO2016014565A2 (enExample)

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