MX2020004568A - Combinación de una terapia celular y un inhibidor de gamma secretasa. - Google Patents

Combinación de una terapia celular y un inhibidor de gamma secretasa.

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Publication number
MX2020004568A
MX2020004568A MX2020004568A MX2020004568A MX2020004568A MX 2020004568 A MX2020004568 A MX 2020004568A MX 2020004568 A MX2020004568 A MX 2020004568A MX 2020004568 A MX2020004568 A MX 2020004568A MX 2020004568 A MX2020004568 A MX 2020004568A
Authority
MX
Mexico
Prior art keywords
secretase inhibitor
gamma secretase
cell therapy
combination
cells
Prior art date
Application number
MX2020004568A
Other languages
English (en)
Inventor
Stanley R Riddell
Melissa Works
Damian J Green
Original Assignee
Juno Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Juno Therapeutics Inc filed Critical Juno Therapeutics Inc
Publication of MX2020004568A publication Critical patent/MX2020004568A/es

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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/46—Cellular immunotherapy
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    • A61K39/46—Cellular immunotherapy
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    • A61K39/4631—Chimeric Antigen Receptors [CAR]
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3092—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated mucins
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001116—Receptors for cytokines
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment

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Abstract

En la presente se proporcionan terapias de combinación que implican la administración de una inmunoterapia que implica una terapia celular, tal como una terapia de células T, y un inhibidor de gamma secretasa. También se proporcionan métodos para modificar, preparar, y producir las células, composiciones que contienen las células e/o inhibidor de gamma secretasa, y kits y dispositivos que contienen y para utilizar, producir y administrar las células e/o inhibidor de gamma secretasa, tal como de acuerdo con los métodos de terapia de combinación proporcionados.
MX2020004568A 2017-11-06 2018-11-06 Combinación de una terapia celular y un inhibidor de gamma secretasa. MX2020004568A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762582308P 2017-11-06 2017-11-06
US201762582937P 2017-11-07 2017-11-07
US201862665450P 2018-05-01 2018-05-01
PCT/US2018/059510 WO2019090364A1 (en) 2017-11-06 2018-11-06 Combination of a cell therapy and a gamma secretase inhibitor

Publications (1)

Publication Number Publication Date
MX2020004568A true MX2020004568A (es) 2020-10-05

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MX2020004568A MX2020004568A (es) 2017-11-06 2018-11-06 Combinación de una terapia celular y un inhibidor de gamma secretasa.

Country Status (13)

Country Link
US (1) US20200289565A1 (es)
EP (1) EP3706754A1 (es)
JP (2) JP7233425B2 (es)
KR (1) KR20200099137A (es)
CN (1) CN111886012A (es)
AU (1) AU2018359907A1 (es)
BR (1) BR112020008812A2 (es)
CA (1) CA3080395A1 (es)
IL (1) IL274361A (es)
MA (1) MA50564A (es)
MX (1) MX2020004568A (es)
SG (1) SG11202003427XA (es)
WO (1) WO2019090364A1 (es)

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