JP6895378B2 - Ｓ１ｐ１受容体に関連する状態の処置方法 - Google Patents
Ｓ１ｐ１受容体に関連する状態の処置方法 Download PDFInfo
- Publication number
- JP6895378B2 JP6895378B2 JP2017535738A JP2017535738A JP6895378B2 JP 6895378 B2 JP6895378 B2 JP 6895378B2 JP 2017535738 A JP2017535738 A JP 2017535738A JP 2017535738 A JP2017535738 A JP 2017535738A JP 6895378 B2 JP6895378 B2 JP 6895378B2
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- compound
- pharmaceutically acceptable
- hydrate
- acceptable salt
- solvate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562100362P | 2015-01-06 | 2015-01-06 | |
| US62/100,362 | 2015-01-06 | ||
| US201562159550P | 2015-05-11 | 2015-05-11 | |
| US62/159,550 | 2015-05-11 | ||
| PCT/US2016/012289 WO2016112075A1 (en) | 2015-01-06 | 2016-01-06 | Methods of treating conditions related to the s1p1 receptor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020046453A Division JP7219732B2 (ja) | 2015-01-06 | 2020-03-17 | Ｓ１ｐ１受容体に関連する状態の処置方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018504398A JP2018504398A (ja) | 2018-02-15 |
| JP2018504398A5 JP2018504398A5 (enExample) | 2019-01-31 |
| JP6895378B2 true JP6895378B2 (ja) | 2021-06-30 |
Family
ID=55174728
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017535738A Active JP6895378B2 (ja) | 2015-01-06 | 2016-01-06 | Ｓ１ｐ１受容体に関連する状態の処置方法 |
| JP2020046453A Active JP7219732B2 (ja) | 2015-01-06 | 2020-03-17 | Ｓ１ｐ１受容体に関連する状態の処置方法 |
| JP2021129838A Withdrawn JP2021175752A (ja) | 2015-01-06 | 2021-08-06 | Ｓ１ｐ１受容体に関連する状態の処置方法 |
| JP2023143336A Pending JP2023158050A (ja) | 2015-01-06 | 2023-09-05 | Ｓ１ｐ１受容体に関連する状態の処置方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020046453A Active JP7219732B2 (ja) | 2015-01-06 | 2020-03-17 | Ｓ１ｐ１受容体に関連する状態の処置方法 |
| JP2021129838A Withdrawn JP2021175752A (ja) | 2015-01-06 | 2021-08-06 | Ｓ１ｐ１受容体に関連する状態の処置方法 |
| JP2023143336A Pending JP2023158050A (ja) | 2015-01-06 | 2023-09-05 | Ｓ１ｐ１受容体に関連する状態の処置方法 |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US11007175B2 (enExample) |
| EP (2) | EP3242666B9 (enExample) |
| JP (4) | JP6895378B2 (enExample) |
| KR (2) | KR102595163B1 (enExample) |
| CN (2) | CN107405332A (enExample) |
| AU (3) | AU2016205361C1 (enExample) |
| CA (1) | CA3002540C (enExample) |
| DK (1) | DK3242666T5 (enExample) |
| ES (1) | ES2995737T3 (enExample) |
| FI (1) | FI3242666T3 (enExample) |
| HU (1) | HUE069888T2 (enExample) |
| IL (2) | IL253197B (enExample) |
| MX (2) | MX394839B (enExample) |
| NZ (1) | NZ734220A (enExample) |
| PL (1) | PL3242666T3 (enExample) |
| PT (1) | PT3242666T (enExample) |
| SI (1) | SI3242666T1 (enExample) |
| UA (1) | UA126268C2 (enExample) |
| WO (1) | WO2016112075A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108558740B (zh) | 2010-01-27 | 2021-10-19 | 艾尼纳制药公司 | S1p1受体调节剂及其盐的制备方法 |
| US11007175B2 (en) | 2015-01-06 | 2021-05-18 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the S1P1 receptor |
| KR102883123B1 (ko) | 2015-06-22 | 2025-11-10 | 아레나 파마슈티칼스, 인크. | Ｓ1ｐ1 수용체-관련 장애에서의 사용을 위한 (ｒ)-2-(7-(4-시클로펜틸-3-(트리플루오로메틸)벤질옥시)-1,2,3,4-테트라히드로시클로-펜타[ｂ]인돌-3-일)아세트산 (화합물 1)의 결정성 ｌ-아르기닌 염 |
| MA47504A (fr) | 2017-02-16 | 2019-12-25 | Arena Pharm Inc | Composés et méthodes de traitement de l'angiocholite biliaire primitive |
| ES2981521T3 (es) * | 2017-02-16 | 2024-10-09 | Arena Pharm Inc | Compuestos y procedimientos para el tratamiento de la enfermedad inflamatoria intestinal con manifestaciones extraintestinales |
| WO2019236757A1 (en) * | 2018-06-06 | 2019-12-12 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the s1p1 receptor |
| US11555015B2 (en) * | 2018-09-06 | 2023-01-17 | Arena Pharmaceuticals, Inc. | Compounds useful in the treatment of autoimmune and inflammatory disorders |
| WO2020072824A1 (en) * | 2018-10-03 | 2020-04-09 | Arena Pharmaceuticals, Inc. | Methods for the treatment of scleroderma |
| CN118649163A (zh) * | 2018-11-30 | 2024-09-17 | 艾尼纳制药公司 | 治疗与s1p1受体有关的病况的方法 |
| WO2020146529A1 (en) * | 2019-01-08 | 2020-07-16 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the s1p1 receptor |
| WO2021067506A1 (en) * | 2019-10-01 | 2021-04-08 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the s1p1 receptor |
| AU2020372647A1 (en) | 2019-10-31 | 2022-06-16 | Idorsia Pharmaceuticals Ltd | Combination of a CXCR7 antagonist with an S1P1 receptor modulator |
| KR20220103750A (ko) * | 2019-11-20 | 2022-07-22 | 아레나 파마슈티칼스, 인크. | S1p1 수용체와 관련된 상태를 치료하는 방법 |
| BR112022012846A2 (pt) * | 2020-01-06 | 2022-09-06 | Arena Pharm Inc | Métodos de tratamento de condições relacionadas ao receptor s1p1 |
| WO2021163355A1 (en) * | 2020-02-11 | 2021-08-19 | Arena Pharmaceuticals, Inc. | Formulations and methods of treating conditions related to the s1p1 receptor |
| EP4212159A4 (en) * | 2020-09-28 | 2024-03-06 | Lg Chem, Ltd. | USE OF SPHINGOSINE-1 PHOSPHATE RECEPTOR AGONISTS |
| WO2022099150A1 (en) * | 2020-11-09 | 2022-05-12 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the s1p1 receptor |
| US20250152556A1 (en) | 2022-01-13 | 2025-05-15 | Arena Pharmaceuticals, Inc. | Etrasimod for use in treating s1p1 receptor-associated disorders in combination with hormone treatment |
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| KR102883123B1 (ko) | 2015-06-22 | 2025-11-10 | 아레나 파마슈티칼스, 인크. | Ｓ1ｐ1 수용체-관련 장애에서의 사용을 위한 (ｒ)-2-(7-(4-시클로펜틸-3-(트리플루오로메틸)벤질옥시)-1,2,3,4-테트라히드로시클로-펜타[ｂ]인돌-3-일)아세트산 (화합물 1)의 결정성 ｌ-아르기닌 염 |
| ES2981521T3 (es) | 2017-02-16 | 2024-10-09 | Arena Pharm Inc | Compuestos y procedimientos para el tratamiento de la enfermedad inflamatoria intestinal con manifestaciones extraintestinales |
| MA47504A (fr) | 2017-02-16 | 2019-12-25 | Arena Pharm Inc | Composés et méthodes de traitement de l'angiocholite biliaire primitive |
| WO2019236757A1 (en) | 2018-06-06 | 2019-12-12 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the s1p1 receptor |
| WO2020072824A1 (en) | 2018-10-03 | 2020-04-09 | Arena Pharmaceuticals, Inc. | Methods for the treatment of scleroderma |
| CN118649163A (zh) | 2018-11-30 | 2024-09-17 | 艾尼纳制药公司 | 治疗与s1p1受体有关的病况的方法 |
| WO2020146529A1 (en) | 2019-01-08 | 2020-07-16 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the s1p1 receptor |
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