AU2016205361C1 - Methods of treating conditions related to the S1P1 receptor - Google Patents

Methods of treating conditions related to the S1P1 receptor Download PDF

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Publication number
AU2016205361C1
AU2016205361C1 AU2016205361A AU2016205361A AU2016205361C1 AU 2016205361 C1 AU2016205361 C1 AU 2016205361C1 AU 2016205361 A AU2016205361 A AU 2016205361A AU 2016205361 A AU2016205361 A AU 2016205361A AU 2016205361 C1 AU2016205361 C1 AU 2016205361C1
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Australia
Prior art keywords
compound
pharmaceutically acceptable
acceptable salt
solvate
hydrate
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AU2016205361A
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AU2016205361A1 (en
AU2016205361B2 (en
Inventor
Alan GLICKLICH
Maria Matilde Sanchez KAM
William R. Shanahan
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Arena Pharmaceuticals Inc
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Arena Pharmaceuticals Inc
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Priority to AU2021200129A priority Critical patent/AU2021200129B2/en
Publication of AU2016205361C1 publication Critical patent/AU2016205361C1/en
Priority to AU2022283660A priority patent/AU2022283660B2/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A61K9/4825—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
AU2016205361A 2015-01-06 2016-01-06 Methods of treating conditions related to the S1P1 receptor Active AU2016205361C1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2021200129A AU2021200129B2 (en) 2015-01-06 2021-01-11 Methods of treating conditions related to the S1P1 receptor
AU2022283660A AU2022283660B2 (en) 2015-01-06 2022-12-06 Methods of treating conditions related to the S1P1 receptor

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562100362P 2015-01-06 2015-01-06
US62/100,362 2015-01-06
US201562159550P 2015-05-11 2015-05-11
US62/159,550 2015-05-11
PCT/US2016/012289 WO2016112075A1 (en) 2015-01-06 2016-01-06 Methods of treating conditions related to the s1p1 receptor

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2021200129A Division AU2021200129B2 (en) 2015-01-06 2021-01-11 Methods of treating conditions related to the S1P1 receptor

Publications (3)

Publication Number Publication Date
AU2016205361A1 AU2016205361A1 (en) 2017-08-17
AU2016205361B2 AU2016205361B2 (en) 2020-10-15
AU2016205361C1 true AU2016205361C1 (en) 2021-04-08

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AU2016205361A Active AU2016205361C1 (en) 2015-01-06 2016-01-06 Methods of treating conditions related to the S1P1 receptor
AU2021200129A Active AU2021200129B2 (en) 2015-01-06 2021-01-11 Methods of treating conditions related to the S1P1 receptor
AU2022283660A Active AU2022283660B2 (en) 2015-01-06 2022-12-06 Methods of treating conditions related to the S1P1 receptor

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AU2021200129A Active AU2021200129B2 (en) 2015-01-06 2021-01-11 Methods of treating conditions related to the S1P1 receptor
AU2022283660A Active AU2022283660B2 (en) 2015-01-06 2022-12-06 Methods of treating conditions related to the S1P1 receptor

Country Status (19)

Country Link
US (4) US11007175B2 (enExample)
EP (2) EP4445956A3 (enExample)
JP (4) JP6895378B2 (enExample)
KR (2) KR102595163B1 (enExample)
CN (2) CN107405332A (enExample)
AU (3) AU2016205361C1 (enExample)
CA (1) CA3002540C (enExample)
DK (1) DK3242666T5 (enExample)
ES (1) ES2995737T3 (enExample)
FI (1) FI3242666T3 (enExample)
HU (1) HUE069888T2 (enExample)
IL (2) IL253197B (enExample)
MX (2) MX386419B (enExample)
NZ (1) NZ734220A (enExample)
PL (1) PL3242666T3 (enExample)
PT (1) PT3242666T (enExample)
SI (1) SI3242666T1 (enExample)
UA (1) UA126268C2 (enExample)
WO (1) WO2016112075A1 (enExample)

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US8853419B2 (en) 2010-01-27 2014-10-07 Arena Pharmaceuticals, Inc. Processes for the preparation of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof
DK3242666T5 (da) 2015-01-06 2025-01-20 Arena Pharm Inc Forbindelsee til anvendelse i behandling af tilstande, der er forbundet med SIP1-receptoren
JP6838744B2 (ja) 2015-06-22 2021-03-03 アリーナ ファーマシューティカルズ， インコーポレイテッド Ｓ１Ｐ１レセプター関連障害における使用のための（Ｒ）−２−（７−（４−シクロペンチル−３−（トリフルオロメチル）ベンジルオキシ）−１，２，３，４−テトラヒドロシクロペンタ［ｂ］インドール−３−イル）酢酸（化合物１）の結晶性Ｌ−アルギニン塩
MA47503A (fr) * 2017-02-16 2021-04-21 Arena Pharm Inc Composés et méthodes pour le traitement de maladies inflammatoires chroniques de l'intestin avec manifestations extra-intestinales
KR20190116416A (ko) 2017-02-16 2019-10-14 아레나 파마슈티칼스, 인크. 원발 담즙성 담관염을 치료하기 위한 화합물 및 방법
ES2987794T3 (es) * 2018-06-06 2024-11-18 Arena Pharm Inc Procedimientos de tratamiento de afecciones relacionadas con el receptor S1P1
KR102836433B1 (ko) * 2018-09-06 2025-07-21 아레나 파마슈티칼스, 인크. 자가면역 및 염증성 장애의 치료에 유용한 화합물
WO2020072824A1 (en) * 2018-10-03 2020-04-09 Arena Pharmaceuticals, Inc. Methods for the treatment of scleroderma
EP3886841A1 (en) * 2018-11-30 2021-10-06 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the s1p1 receptor
CA3124701A1 (en) * 2019-01-08 2020-07-16 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the s1p1 receptor
TW202114656A (zh) * 2019-10-01 2021-04-16 美商艾尼納製藥公司 治療與s1p1 受體相關之病況的方法
KR20220093330A (ko) 2019-10-31 2022-07-05 이도르시아 파마슈티컬스 리미티드 Cxcr7 안타고니스트와 s1p1 수용체 조절인자의 조합
CN115038437A (zh) * 2019-11-20 2022-09-09 艾尼纳制药公司 治疗与s1p1受体相关的病症的方法
BR112022012846A2 (pt) * 2020-01-06 2022-09-06 Arena Pharm Inc Métodos de tratamento de condições relacionadas ao receptor s1p1
WO2021163355A1 (en) * 2020-02-11 2021-08-19 Arena Pharmaceuticals, Inc. Formulations and methods of treating conditions related to the s1p1 receptor
TW202222314A (zh) * 2020-09-28 2022-06-16 南韓商Ｌｇ化學股份有限公司 神經鞘胺醇－１－磷酸受體促效劑的用途
CA3200998A1 (en) * 2020-11-09 2022-05-12 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the s1p1 receptor
WO2023135506A1 (en) 2022-01-13 2023-07-20 Arena Pharmaceuticals, Inc. Etrasimod for use in treating s1p1 receptor-associated disorders in combination with hormone treatment

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