JP5674777B2 - 分析物モニタリング装置および使用方法 - Google Patents
分析物モニタリング装置および使用方法 Download PDFInfo
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- JP5674777B2 JP5674777B2 JP2012517811A JP2012517811A JP5674777B2 JP 5674777 B2 JP5674777 B2 JP 5674777B2 JP 2012517811 A JP2012517811 A JP 2012517811A JP 2012517811 A JP2012517811 A JP 2012517811A JP 5674777 B2 JP5674777 B2 JP 5674777B2
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Description
「対電極」は、作用電極と対になる電極を称し、作用電極を通る電流と大きさが等しく符号が反対の電流を通す。本発明に関して、「対電極」という用語は、参照電極としても機能する対電極(すなわち、対/参照電極)を含むことを意味する。
本発明の分析物モニタリングシステムは様々な条件下で利用できる。この分析物モニタリングシステムに使用されるセンサおよび他のユニットの特定の構成は、分析物モニタリングシステムが意図される用途、および分析物モニタリングシステムが動作する条件に依存するであろう。分析物モニタリングシステムのある実施の形態は、患者または使用者に埋め込まれるように構成されたセンサを含む。例えば、血中の分析物レベルを直接検査するために動脈系または静脈系にセンサを埋め込んでもよい。あるいは、間質液中の分析物レベルを決定するために間質組織内にセンサを埋め込んでもよい。このレベルは、血液または他の流体中の分析物レベルに相関付けてもおよび/または変換されてもよい。埋込みの部位および深さは、センサの特定の形状、構成要素、および形態に影響するであろう。いくつかの場合には、センサの埋込みの深さを制限するために、皮下埋込みが好ましいであろう。他の流体中の分析物レベルを決定するために、体の他の領域にセンサを埋め込んでもよい。本発明の分析物モニタリングシステムに使用するのに適切なセンサの例が、ここに引用する、米国特許第6134461号として発行された米国特許出願第09/034372号明細書に記載されている。
センサ42は、図2に示されるように、基板50上に形成された少なくとも1つの作用電極58を含む。センサ42は、少なくとも1つの対電極60(または対/参照電極)および/または少なくとも1つの参照電極62(図8参照)を含んでもよい。対電極60および/または参照電極62は、基板50上に形成しても、または別個のユニットであってもよい。例えば、対電極および/または参照電極は、これも患者に埋め込まれる第2の基板上に形成されても、または埋込可能なセンサのいくつかの実施の形態について、作用電極が患者に埋め込まれた状態で、対電極および/または参照電極を患者の皮膚の上に配置してもよい。埋込可能な作用電極と共に皮膚上の対および/または参照電極を使用することが、全ての目的のためにここに引用する米国特許第5593852号明細書に記載されている。
基板50は、例えば、高分子またはプラスチック材料およびセラミック材料を含む、様々な非導電性材料を使用して形成してよい。特定のセンサ42に適切な材料は、少なくとも一部には、センサ42の所望の用途および材料の性質に基づいて決定してよい。
少なくとも1つの導電性トレース52を、作用電極58の構築に使用するための基板上に形成する。その上、電極(例えば、追加の作用電極、並びに対、対/参照、および/または参照電極)および温度プローブなどの他の構成要素として使用するために、他の導電性トレース52を基板50上に形成してもよい。導電性トレース52は、図2に示されるように、センサ42の長さ57に沿った距離のほとんどに延在してもよいが、これは必要ではない。導電性トレース52の配置は、分析物モニタリングシステムの特定の構成に依存するであろう(例えば、センサ42に対する制御ユニット接点および/またはサンプルチャンバの配置)。埋込可能なセンサ、特に皮下に埋込可能なセンサについて、導電性トレースは、典型的に、埋め込まなければならないセンサの量を最小にするためにセンサ42の先端に近接して延在する。
一般に、導電性トレース52の各々は導体パッド49を含む。導体パッド49は、単に、導体パッド49が制御ユニット(例えば、図1のセンサ制御ユニット)の導電接点と接触せしめられることを除いて、トレース52の残りから見分けの付かない導電性トレース52の一部分であってよい。しかしながら、より一般には、導体パッド49は、制御ユニット上の接点との接続を容易にするためにトレース52の他の領域より幅が広い導電性トレース52の領域である。導電性トレース52の幅と比べて導体パッド49を比較的大きく作ることによって、導体パッド49と制御ユニット上の接点との間の正確な位置合せの必要が、小さな導体パッドの場合よりも重大ではなくなる。
数多くの例示の電極構成を以下に記載するが、他の構成を使用してもよいことが理解されよう。図3Aに示されるある実施の形態において、センサ42は、2つの作用電極58a,58bおよび1つの対電極60を含み、この対電極は参照電極としても機能する。別の実施の形態において、センサは、図3Bに示されるように、1つの作用電極58a、1つの対電極60、および1つの参照電極62を含む。これらの実施の形態の各々は、電極の全てが基板50の同じ側に形成されたものとして示されている。
酸素などのある分析物は、作用電極58上で直接、電気酸化または電気還元され得る。グルコースおよび乳酸などの他の分析物については、その分析物の電気酸化または電気還元を促進するために、少なくとも1種類の電子移動剤および/または少なくとも1種類の触媒の存在が要求される。作用電極58上で直接、電気酸化または電気還元され得る、酸素などの分析物に触媒を使用してもよい。これらの分析物について、各作用電極58は、その作用電極58の作用表面に近接してまたはその上に形成された検出層64を有する。一般に、検出層64は、センサ42の先端近くであることが多い、作用電極58の小さい部分の近くに、またはその部分のみに形成される。これにより、センサ42を形成するのに必要な材料の量が制限され、分析物含有流体(例えば、体液、サンプル流体、または分散媒)と接触するための最良の位置に検出層64が配置される。
多くの実施の形態において、検出層64は、図3Aおよび3Bに示されるように、作用電極58の導電材料56と接触した1種類以上の電子移動剤を含有する。本発明のいくつかの実施の形態において、センサ42が患者に埋め込まれている期間中に、作用電極58からの電子移動剤の浸出はほとんどまたは全くない。拡散性または浸出可能な(すなわち、放出可能な)電子移動剤は分析物含有流体中に拡散し、したがって、時間経過でセンサの感度が減少することによって電極の有効性が低下する。その上、埋込可能なセンサ42内の拡散性または浸出性電子移動剤により、患者に損傷が生じるかもしれない。これらの実施の形態において、24時間に亘り、より好ましくは72時間に亘り分析物含有流体中に浸漬された後、電子移動剤の好ましくは少なくとも90%、より好ましくは少なくとも95%、最も好ましくは少なくとも99%がセンサ上に堆積されたままである。特に、埋込可能なセンサについて、24時間に亘り、より好ましくは72時間に亘り37℃で体液中に浸漬された後、電子移動剤の好ましくは少なくとも90%、より好ましくは少なくとも95%、最も好ましくは少なくとも99%がセンサ上に堆積されたままである。
検出層64は、分析物の反応を触媒することのできる触媒も含んでよい。触媒は、いくつかの実施の形態において、電子移動剤として働いてもよい。適切な触媒の一例は、分析物の反応を触媒する酵素である。例えば、分析物がグルコースである場合、グルコースオキシダーゼ、グルコースデヒドロゲナーゼ(例えば、ピロロキノリンキノングルコースデヒドロゲナーゼ(PQQ))、またはオリゴ糖デヒドロゲナーゼなどの酵素を使用してよい。分析物が乳酸である場合、乳酸オキシダーゼまたは乳酸デヒドロゲナーゼを使用してよい。分析物が酸素である、または分析物の反応に応答して酸素が生成されるまたは消費される場合、ラッカーゼを使用してよい。
分析物を電気分解するために、作用電極58と対電極60に電位(参照電位に対して)を印加する。印加される電位の最小の大きさは、特定の電子移動剤、分析物(分析物が電極で直接電気分解される場合)、または第2の化合物(そのレベルが分析物のレベルに依存する、酸素または過酸化水素などの第2の化合物が、電極で直接電気分解される場合)に依存することが多い。印加される電位は、通常等しいか、または所望の電気化学反応に応じて、どれも電極で直接電気分解される、電子移動剤、分析物、または第2の化合物の酸化還元電位よりも、酸化性または還元性である。作用電極での電位は、一般に、電気化学反応を完了またはほぼ完了へと推進するのに十分に大きい。
様々な随意的アイテムがセンサに含まれてもよい。随意的アイテムの1つは、温度プローブ66(図8および11)である。温度プローブ66は、様々な公知の設計および材料を使用して製造してよい。ある例示の温度プローブ66は、温度依存特徴を有する材料を使用して形成された温度依存性要素72を通じて互いに接続された2つのプローブ導線68,70を使用して形成される。適切な温度依存特徴の一例は、温度依存性要素72の抵抗である。
随意的な生体適合被膜層75が、図9に示されるように、少なくとも、患者の皮下に挿入されるセンサ42の部分を覆って形成されている。この随意的な生体適合被膜層75は1つ以上の機能を果たしてよい。生体適合被膜層75は、大きな生体分子が電極中に浸透するのを防ぐ。このことは、排除すべき生体分子より小さい細孔径を有する生体適合被膜層75を使用することによって行われる。そのような生体分子は、電極および/または検出層64を塞ぎ、それによって、センサ42の有効性を減少させ、所定の分析物濃度について予測される信号振幅を変えてしまうであろう。作用電極58が塞がれると、センサ42の有効寿命が減少するであろう。生体適合層75は、センサ42へのタンパク質の付着、血栓の形成、およびセンサ42と体との間の他の望ましくない相互作用を防いでもよい。
干渉物質除去層(図示せず)がセンサ42に含まれてもよい。干渉物質除去層は、生体適合層75内、または質量輸送制限層74(以下に記載する)に含まれても、もしくは別個の層であってもよい。干渉物質は、直接的にまたは電子移動剤を介して、電極で電気還元または電気酸化されて、擬似信号を生成する分子または他の種である。ある実施の形態において、被膜または膜が、1種類以上の干渉物質が作用電極58の周りの領域中に浸透するのを防ぐ。このタイプの干渉物質除去層は、分析物に対するよりも、干渉物質に対して、浸透性がずっと少ない。
分析物、例えば、グルコースまたは乳酸の、作用電極58の周りの領域中への質量輸送の速度を減少させるための拡散制限バリアとして働く質量輸送制限層74をセンサに含ませてもよい。分析物の拡散を制限することによって、作用電極58の近傍にある分析物の定常状態濃度(体液またはサンプル流体中の分析物の濃度に比例する)を減少させることができる。これにより、まだ正確に測定することができる分析物の上限範囲が広がり、電流が分析物のレベルとほぼ線形に増加する範囲も広がるであろう。
埋込可能なセンサは、必要に応じて、患者に埋め込まれる基板の一部分の上に配置された抗凝固剤を有してもよい。この抗凝固剤により、特にセンサの挿入後の、センサの周りでの血液または他の体液の凝固が減少するかなくなるであろう。血栓は、センサを塞いだり、センサ中に拡散する分析物の量を再生不可能に減少させてしまうかもしれない。有用な抗凝固剤の例としては、ヘパリンおよび組織プラスミノゲン活性化因子(TPA)、並びに他の公知の抗凝固剤が挙げられる。
センサ42は、生体内分析物モニタ、特に埋込可能な分析物モニタにおいて交換できる構成要素であるように設計してもよい。一般に、センサ42は数日間に亘り作動できる。作動期間は、好ましくは少なくとも一日、より好ましくは少なくとも三日間、最も好ましくは少なくとも一週間である。次に、センサ42を取り出し、新しいセンサと交換できる。センサ42の寿命は、電極のファウリングにより、もしくは電子移動剤または触媒の浸出によって、減少するであろう。センサ42の寿命へのこれらの制限は、上述したように、それぞれ、生体適合層75または浸出不能な電子移動剤および触媒の使用により克服できる。
図12に示されるように、患者の皮下にセンサ42を挿入するために、挿入装置120を使用することができる。挿入装置120は、一般に、金属または剛性プラスチックなどの構造的に剛性の材料を使用して形成される。好ましい材料としては、ステンレス鋼およびABS(アクリロニトリル・ブタジエン・スチレン)プラスチックが挙げられる。いくつかの実施の形態において、挿入装置120は、患者の皮膚の貫通を容易にするために、先端121で尖っているおよび/または鋭くなっている。鋭く薄い挿入装置により、センサ42の挿入の際に患者が感じる痛みが減少するであろう。他の実施の形態において、挿入装置120の先端121は、鈍端または平らな形状を含む他の形状を有する。これらの実施の形態は、挿入装置120が、皮膚を貫通するのではなく、センサ42が皮膚に押し付けられたときにセンサ42の構造的支持体として働く場合に、特に有用であろう。
皮膚上センサ制御ユニット44は、患者の皮膚上に配置されるように構成されている。皮膚上センサ制御ユニット44は、必要に応じて、患者にとって快適であり、例えば、患者の衣類の下に隠せるような形状で形成される。太股、足、上腕、肩、または腹部が、隠した状態を維持するように皮膚上センサ制御ユニット44を配置するための、患者の体の都合よい部分である。しかしながら、皮膚上センサ制御ユニット44を、患者の体の他の部分に配置してもよい。皮膚上センサ制御ユニット44のある実施の形態は、図14〜16に示されるように、隠しやすいように薄い楕円形状を有する。しかしながら、他の形状とサイズを使用してもよい。
皮膚上センサ制御ユニット44は、一般に、センサ42および分析物モニタリングシステム40を作動させる電子部品の少なくとも一部分も含む。皮膚上センサ制御ユニット44内の電子部品のある実施の形態が図18Aのブロック図として示されている。皮膚上センサ制御ユニット44の電子部品は、一般に、皮膚上センサ制御ユニット44およびセンサ42を作動させるための電源95、センサ42から信号を得てこのセンサを作動させるためのセンサ回路97、センサ信号を所望のフォーマットに変換する測定回路96、および最低限で、センサ回路97および/または測定回路96から信号を得、その信号を随意的なトランスミッタ98に提供する処理回路109を含む。いくつかの実施の形態において、処理回路109は、センサ42からの信号を部分的にまたは完全に評価し、その結果得られたデータを随意的なトランスミッタ98に伝達するおよび/または分析物のレベルが閾値を超えた場合に随意的な警報システム104(図18B参照)を起動してもよい。処理回路109はデジタル論理回路を含むことが多い。
1つ以上のレシーバ/ディスプレイユニット46,48は、センサ42によって生成されるデータへのアクセスを容易にするため分析物モニタリング装置40を備えてもよく、また、いくつかの実施の形態においては、皮膚上センサ制御ユニット44からの信号を処理して、皮下組織中の分析物の濃度またはレベルを測定してもよい。小型レシーバ/ディスプレイユニット46は、患者が携帯することもできる。これらのユニット46は、手のひらサイズとすることもでき、および/または、患者が携帯するカバンまたはハンドバック内またはベルト上に収まるように適合させてもよい。小型レシーバ/ディスプレイユニット46の1つの実施の形態は、例えば、使用者が医療装置を使用している人であることが分からないように、ポケットベルの外観を有する。そのようなレシーバ/ディスプレイユニットは、必要に応じて、一方向または双方向の呼出し機能を有してもよい。
図25は、本発明による、センサに基づく薬剤送達システム250のブロック図を示す。このシステムは、1つ以上のセンサ252からの信号に応答して高レベルまたは低レベルの分析物の影響を打ち消すように薬剤を供給してもよい。あるいは、このシステムは、薬剤が確実に所望の治療域内に留まるように薬剤濃度をモニタする。薬剤送達システムは、1つ以上(好ましくは2つ以上)の皮下に埋め込まれたセンサ252、皮膚上センサ制御ユニット254、レシーバ/ディスプレイユニット256、データ記憶および制御装置モジュール258、および薬剤投与システム260を備えている。場合によって、レシーバ/ディスプレイユニット256と、データ記憶および制御装置モジュール258と、薬剤投与システム260とは、単一ユニット内に一体化されていてもよい。センサに基づく薬剤送達システム250は、1つ以上のセンサ252からのデータを使用して、データ記憶および制御装置モジュール252内の制御アルゴリズム/機構に必要な入力情報を提供し、薬剤の投与を調節する。一例として、グルコースセンサを使用して、インスリンの投与を制御および調節することができるであろう。
44 センサ制御ユニット
46,48 レシーバ/ディスプレイユニット
66 温度プローブ
95 電源
96 測定回路
97 センサ回路
98,160 トランスミッタ
99 温度プローブ回路
101 基準電圧発生装置
102 データ記憶ユニット
103 監視回路
150 レシーバ
154 ディスプレイ
156 警報システム
Claims (26)
- 一体型モニタおよびディスプレイユニットにおいて、
筐体、
前記筐体内に配置された無線周波数(RF)レシーバであって、経皮分析物センサからの分析物信号に関連するデータを送信するように構成され配置されたトランスミッタからデータを受信するためのレシーバ、
前記筐体に連結され、生体外分析物センサを収容するように構成された分析物センサポートであって、前記生体外分析物センサが、該生体外分析物センサ上に配置された流体サンプルに関連する分析物信号を発生するものである分析物センサポート、および
前記筐体内に配置されたプロセッサであって、前記生体外分析物センサにより生成された前記分析物信号に少なくともある程度基づいて前記経皮分析物センサからの分析物信号に関連するデータを検証するように構成されたプロセッサ、
を備え、
前記分析物センサポートが、所定の較正パラメータに関連付けられていない第1のタイプの生体外分析物センサおよび前記所定の較正パラメータに関連付けられた第2のタイプの生体外分析物センサを収容するように構成されており、
前記較正パラメータは前記生体外分析物センサを較正するためのものであることを特徴とする一体型モニタおよびディスプレイユニット。 - 前記プロセッサが、前記第1のタイプの生体外分析物センサが前記分析物センサポート内に収容されたときに、第1の所定のルーチンを実行するように構成されており、該プロセッサが、前記第2のタイプの生体外分析物センサが前記分析物センサポート内に収容されたときに、第2の所定のルーチンを実行するように構成されていることを特徴とする請求項1記載の一体型モニタおよびディスプレイユニット。
- 前記分析物センサポートにより配置される生体外分析物センサをさらに備えることを特徴とする請求項1記載の一体型モニタおよびディスプレイユニット。
- 前記第1のタイプの生体外分析物センサが、該第1のタイプの生体外分析物センサが前記分析物センサポート内に収容された際に、該第1のタイプの生体外分析物センサに関連する較正情報の使用者による入力を要求することを特徴とする請求項1記載の一体型モニタおよびディスプレイユニット。
- 前記所定の較正パラメータを記憶するように構成されたメモリをさらに備えることを特徴とする請求項1記載の一体型モニタおよびディスプレイユニット。
- 前記所定の較正パラメータが較正コードを含むことを特徴とする請求項1記載の一体型モニタおよびディスプレイユニット。
- 前記分析物センサポートが、前記第2のタイプの生体外分析物センサの表面上の挿入モニタと接触するように構成され、前記プロセッサが、前記第2のタイプの生体外分析物センサの前記挿入モニタに基づいて前記所定の較正パラメータの関連性を決定するように構成されていることを特徴とする請求項1記載の一体型モニタおよびディスプレイユニット。
- 前記プロセッサが、前記挿入モニタの形状に基づいて前記所定の較正パラメータの関連性を決定するように構成されていることを特徴とする請求項7記載の一体型モニタおよびディスプレイユニット。
- 前記プロセッサが、前記挿入モニタの位置に基づいて前記所定の較正パラメータの関連性を決定するように構成されていることを特徴とする請求項7記載の一体型モニタおよびディスプレイユニット。
- 前記プロセッサが、前記挿入モニタの電気的特徴に基づいて前記所定の較正パラメータの関連性を決定するように構成されていることを特徴とする請求項7記載の一体型モニタおよびディスプレイユニット。
- 前記プロセッサが、前記挿入モニタの抵抗に基づいて前記所定の較正パラメータの関連性を決定するように構成されていることを特徴とする請求項7記載の一体型モニタおよびディスプレイユニット。
- 前記分析物センサポートが、前記挿入モニタと接触するように構成された第1の接触構造および第2の接触構造を含むことを特徴とする請求項7記載の一体型モニタおよびディスプレイユニット。
- 前記第2のタイプの生体外分析物センサが、前記所定の較正パラメータに関連付けられた較正調節された生体外分析物センサであることを特徴とする請求項1記載の一体型モニタおよびディスプレイユニット。
- 前記所定の較正パラメータが、前記第2のタイプの生体外分析物センサに使用されるユニバーサル較正パラメータであることを特徴とする請求項1記載の一体型モニタおよびディスプレイユニット。
- 前記プロセッサが、前記経皮分析物センサからの分析物信号の変化速度が所定の許容範囲内にあるか否かを判定することによって前記データを検証するように構成されていることを特徴とする請求項1記載の一体型モニタおよびディスプレイユニット。
- 前記プロセッサが、前記経皮分析物センサからの分析物信号が所定の許容分析物信号範囲内にあるか否かを判定することによって前記データを検証するように構成されていることを特徴とする請求項1記載の一体型モニタおよびディスプレイユニット。
- 前記プロセッサが、前記皮下分析物センサからの分析物信号に関連するデータに基づいて治療行為を推奨するおよび/または実行する前に、前記データを検証するように構成されていることを特徴とする請求項1記載の一体型モニタおよびディスプレイユニット。
- 前記RFレシーバが、所定の時間間隔で前記トランスミッタにより送信されたデータを受信するように構成されていることを特徴とする請求項1記載の一体型モニタおよびディスプレイユニット。
- 前記分析物がグルコースであることを特徴とする請求項1記載の一体型モニタおよびディスプレイユニット。
- 流体サンプルがその上に配置された生体外分析物検査片の存在を、該検査片を収容するように構成された検査片ポートを含む一体型モニタを使用して、検出する工程、
前記検査片ポート内に前記検査片を検出した際に、該検査片が、使用者が較正情報を入力する必要がある第1のタイプであるか、較正が自動的である第2のタイプであるかを判定する工程、
前記一体型モニタを使用し前記生体外検査片の判定されたタイプに応じて、前記流体サンプルに基づいて前記検査片により生成される1つ以上の信号を処理する工程、および
前記一体型モニタを使用してトランスミッタから、各々がモニタされた分析物レベルに対応する複数の時間間隔の空いた信号を無線で受信する工程、
を有してなる方法であって、
前記検査片により生成された前記1つ以上の信号を処理する工程が、
前記検査片の判定されたタイプが前記第1のタイプであるときに、該検査片に関連付けられた較正パラメータを提供するリクエストを生成し、前記検査片の判定されたタイプが前記第2のタイプであるときに、該検査片に関連付けられた前記較正パラメータを検索するものであり、
前記較正パラメータは前記検査片を較正するためのものであることを特徴とする方法。 - 前記リクエストされた較正パラメータが受け取られたときに、前記第1のタイプの検査片により生成される前記1つ以上の信号に基づいて、対応する分析物レベルを決定する工程、または検索された前記較正パラメータに基づいて第2のタイプの検査片により生成された前記1つ以上の信号に基づいて対応する分析物レベルを決定する工程を含むことを特徴とする請求項20記載の方法。
- 前記一体型モニタを使用して、検索された前記較正パラメータに基づいて、使用者のやりとりなく自動的に、前記第2のタイプの検査片により生成された前記1つ以上の信号を較正する工程を含むことを特徴とする請求項20記載の方法。
- 処理された前記1つ以上の信号に基づいて、前記一体型モニタを使用して、受信された前記複数の時間間隔の空いた信号を較正する工程を含むことを特徴とする請求項20記載の方法。
- 筐体、
前記筐体に連結された検査片インターフェース、
前記筐体内に配置された1つ以上のプロセッサ、および
命令を記憶するための、前記筐体内に配置されたメモリ、
を備えた装置であって、
前記命令が、前記1つ以上のプロセッサにより実行されたときに、該1つ以上のプロセッサに、
(1)前記検査片インターフェースで流体サンプルがその上に配置された生体外分析物検査片の存在を検出させ、
(2)該検査片インターフェース内で該検査片の存在を検出した際に、該検査片が、使用者が較正情報を前記装置に入力する必要がある第1のタイプであるか、較正が自動的である第2のタイプであるかを判定させ、
(3)前記1つ以上のプロセッサを使用し前記検査片の判定されたタイプに応じて、前記流体サンプルに基づいて該検査片により生成される1つ以上の信号を処理させ、
(4)トランスミッタからの、各々がモニタされた分析物レベルに対応する、複数の時間間隔の空いた信号を無線で受信させ、
(5)前記検査片の判定されたタイプが前記第1のタイプである場合には、該検査片に関連付けられた較正パラメータを提供するように、リクエストを生成させるものであり、前記検査片の判定されたタイプか前記第2のタイプである場合には、前記メモリから該検査片に関連付けられた前記較正パラメータを検索させるように、リクエストを生成させるものであり、
前記較正パラメータは前記検査片を較正するためのものであることを特徴とする装置。 - 前記メモリが、前記1つ以上のプロセッサにより実行されたときに、該1つ以上のプロセッサに、検索された前記較正パラメータに基づいて、使用者のやりとりなく自動的に、前記第2のタイプの検査片により生成される前記1つ以上の信号を較正させる命令を含むことを特徴とする請求項24記載の装置。
- 前記メモリが、前記1つ以上のプロセッサにより実行されたときに、該1つ以上のプロセッサに、前記検査片により生成された前記1つ以上の信号に基づくモニタされた分析物レベルに対応する、受信された前記複数の時間間隔の空いた信号を較正させる命令を含むことを特徴とする請求項24記載の装置。
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CN102469964B (zh) | 2015-01-07 |
US20130116525A1 (en) | 2013-05-09 |
EP2448487A4 (en) | 2014-08-06 |
EP2448487A1 (en) | 2012-05-09 |
JP2012531947A (ja) | 2012-12-13 |
AU2010266534B2 (en) | 2014-06-12 |
BRPI1011321A2 (pt) | 2016-03-15 |
CA2764069A1 (en) | 2011-01-06 |
US20100094111A1 (en) | 2010-04-15 |
US20150094554A1 (en) | 2015-04-02 |
US8346337B2 (en) | 2013-01-01 |
CN102469964A (zh) | 2012-05-23 |
AU2010266534A1 (en) | 2011-12-15 |
WO2011002693A1 (en) | 2011-01-06 |
US8920319B2 (en) | 2014-12-30 |
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