WO2000013580A1 - Device for determination of an analyte in a body fluid intergrated with an insulin pump - Google Patents

Device for determination of an analyte in a body fluid intergrated with an insulin pump Download PDF

Info

Publication number
WO2000013580A1
WO2000013580A1 PCT/US1999/020978 US9920978W WO0013580A1 WO 2000013580 A1 WO2000013580 A1 WO 2000013580A1 US 9920978 W US9920978 W US 9920978W WO 0013580 A1 WO0013580 A1 WO 0013580A1
Authority
WO
Grant status
Application
Patent type
Prior art keywords
blood glucose
insulin pump
insulin
glucose meter
combined blood
Prior art date
Application number
PCT/US1999/020978
Other languages
French (fr)
Other versions
WO2000013580A9 (en )
WO2000013580A8 (en )
Inventor
Su I. Yum
Joel S. Douglas
Jeffrey N. Roe
Original Assignee
Amira Medical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/48Other medical applications
    • A61B5/4836Diagnosis combined with treatment in closed-loop systems or methods
    • A61B5/4839Diagnosis combined with treatment in closed-loop systems or methods combined with drug delivery
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
    • A61M5/1723Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00Measuring parameters of the user
    • A61M2230/20Blood composition characteristics
    • A61M2230/201Glucose concentration

Abstract

A combined blood glucose meter and insulin pump is disclosed, comprising a housing, a meter display visible from the outside of the housing, and at least one test strip that is stored in the housing. In an alternative embodiment, the combined blood glucose meter and insulin pump further comprise an optics system to receive colorimetric data from the test sample.

Description

DEVICE FOR DETERMINATION OF AN ANALYTE IN A BODY FLUID INTEGRATED WITH AN INSULIN PUMP

FIELD OF THE INVENTION

The present invention relates to a test device and determination of a chemical or biochemical component (analyte) in an aqueous body fluid, such as whole blood and an infusion system for delivering a chemical therapy to a patient. In particular the present invention relates to an infusion system integrated with an electronic system using a dry reagent test strip from which an analyte presence and/or concentration is determined by use of an instrument. A common use of such test strips is for determination of glucose level in blood by diabetics and the delivery of insulin based on the glucose result.

BACKGROUND OF THE INVENTION

Numerous devices have been developed to test for presence and quantity of analytes in aqueous samples, such as whole blood or urine. The patent and technical literature of the last thirty years is replete with inventions which utilize a reagent strip containing a dry chemistry reagent system, that is, a system in which the wet chemistries are imbibed into an absorbent or bibulous medium, dried, and later reconstituted by fluid from the test sample. The reagent strips contain an indicator which changes color or a chemical system which produces an electrical signal proportional to the presence or concentration of a particular analyte in a biological fluid applied to the strip. These strips may be read colorirnetrically by an instrument calibrated or programmed to detect a certain color or by amphometrically or culombic means. Although some of these strips use reduction chemistries, more commonly they involve an oxidizable dye or dye couple. Some of the strips include an enzyme, such as glucose oxidase, which is capable of oxidizing glucose to gluconic acid and hydrogen peroxide.

The patient may also use an automated system to deliver drug therapy, such as insulin in diabetics. These systems are normally referred to as infusion pumps and are used to deliver such agents as insulin. The patient will use a diagnostic instrument and test strip to determine their analyte level and will then determine the appropriate therapy change and modify the delivery dosage of their infusion pump. However, this requires the patient to maintain and carry two separate devices, such as a monitoring system and an insulin delivery infusion pump. (See, for example, U.S. Pat. No. 4,935,346, to Phillips et al.) Examples of these devices, in addition to those used to test blood glucose, include tests for cholesterol, triglycerides, calcium or albumin in whole blood, and for protein, ketones, albumin or glucose in urine.

The Diabetes Complications and Control Trial, which was a study sponsored by the NIH, demonstrated conclusively that careful control of blood glucose levels can significantly reduce the incidence of serious complications of diabetes such as vision loss and kidney malfunction. Most diabetics must test themselves periodically in order to make appropriate adjustments to their diet or medication. It is therefore especially important for diabetics to have rapid, inexpensive, and accurate reagent strips for glucose determination. The convenience of having both the insulin delivery and monitoring system in one easy to use and carry unit will help provide an incentive for the patient to monitor and adjust their therapy appropriately to improve their condition. The technologies embodied in the products which have been developed to date have certain limitations from the perspective of the end user and/or the manufacturer. There is, therefore, a need to overcome some of the limitations of currently available testing and infusion systems.

U.S. Pat. No.4,935,346, issued to Phillips, et al., discloses a system wherein a whole blood sample is applied to the device and indicator development occurs in the presence of the colored components of the sample. Measurements of the color change in the indicator are made at two distinct wavelengths to eliminate the interferences from the presence of colored blood components. The unit is of considerable size and requires up to 12μ of sample to perform a test.

Numerous electrochemical testing systems and related methods are known in the art. For example. European Patent Publication No.0255291 B I, to Birch et al., describes methods and an apparatus for making electrochemical measurements, in particular but not exclusively for the purpose of carrying out microchemical testing on small liquid biological samples of clinical origin.

European Patent Publication No.O 351 891 B 1, to Hill et al., teaches a method of making an electrochemical sensor by printing. The sensor is used to detect, measure or monitor a given dissolved substrate in a mixture of dissolved substrates, most specifically glucose in body fluid.

U.S. Patent No.5,391, 250, to Cheney II et al., teaches a method of fabricating thin film electrochemical sensors for use in measuring subcutaneous or transdermal glucose. Fabrication of the sensors comprises placing a thin film base layer of insulating material onto a rigid substrate. Conductor elements for the sensors are formed on the base layer using contact mask photolithography and a thin film cover layer. U.S. Patent No. 5,437,999, to Diebold et al., teaches a method of fabricating thin film electrochemical devices which are suitable for biological applications using photolithography to define the electrode areas. The disclosures of each of the above patent specifications are incorporated herein by reference in their entirety.

Various infusion pump systems have been described in the current art and include U.S. Patent No. 4,704,029, to Van Heuvelen, which teaches a blood glucose monitor which is applicable for use as an implantable unit for controlling an insulin pump.

U.S. Patent No. 4,436,094, to Cerami, teaches a method for continuous monitoring of the glucose concentration which can be tied to an infusion device.

U.S. Patent No. 5,062,841, to Siegel, teaches an implantible self-regulating mechanochemical insulin pump.

U.S. Patent No. 5,665,065, to Colman et al. , teaches a medication infusion device with a blood glucose data input method.

U.S. Patent No. 5,383,865, to Michel, teaches a medication dispensing device comprising an injector attached to a cartridge with a drive mechanism.

U.S. Patent No. 5,176,644, to Srisathapat et al., discloses a medication infusion pump with a simplified pressure reservoir.

The disclosures of the above patents are incorporated herein by reference. The prior-art devices and methods of the above references provide varying degrees of effectiveness of blood analysis and drug infusion at varying degrees of complexity.

It is an object of the present invention to provide improved devices and methods to improve the performance and minimize the complexity compared to the prior-art devices.

It is a further object of the present invention to provide an integrated infusion pump and monitoring system.

It is another object of this invention to provide an integrated infusion pump, sampling system and monitoring system.

The above objects as well as others are achieved by die devices, methods and systems of this invention as disclosed herein.

SUMMARY OF THE INVENTION

In one aspect this invention provides a method of sampling a body fluid and applying the sample to a test strip which is either inserted or removed from the test strip holder located on the analyte testing portion of a combined insulin pump and glucose monitoring system. Wizen the test strip is positioned in the glucose monitoring system, the system then reads the analyte concentration and displays a value for that reading on a display located on the combined device.

In a preferred embodiment of the invention the device consists of a combined insulin delivery pump, blood glucose monitoring device and lancing system for the extraction of a blood sample. The system provides a small convenient package which eliminates the need for the patient to carry three separate devices.

In a next preferred embodiment of this invention the device has a storage compartment for test strips to protect them from damage due to physical stress, moisture or light.

In another embodiment of this invention the device consist of a combined blood glucose meter and insulin pump.

The method comprises applying a blood sample to the test strip and reading the glucose concentration from the meter display. The display can be shared by the insulin delivery system or separate depending on the design of the instrument. The insulin delivery system settings are either modified by the patient or an algorithm in the electronic system calculates the system settings. This permits the fluid to pass through the capillary spreading layer/filter into the membrane, then reading or measuring on the test side of the membrane the indication provided by the indicator of the presence or concentration of the analyte.

The above embodiments of the devices of the invention with the appropriate dry chemistry system in the matrix member can be used in test strips which may be read or measured in an electronic meter.

The above sets forth the generic aspects of the various devices and methods of the. present invention. These devices and methods are more fully described in the drawings and the descriptions below. BRIEF DESCRIPTION OF THE DRAWINGS

Figure 1 is an isometric view an insulin pump and combined test device.

Figure 2 is an isometric view of the insulin pump, test device, lancing system and test strip.

Figure 3 is a block diagram of the system components for a combined meter and insulin pump.

DETAILED DESCRIPTION OF THE INVENTION

The devices of the present invention are simpler to use and are easier and less costly to manufacture than most devices previously available. This is especially important for diabetics who rely on blood glucose testing multiple times per day to keep their disease under control.

The ease of use and portability of these devices will facilitate increased patient compliance with recommended testing routines and will result in improved overall health of diabetic patients.

In one or more aspects of this invention an insulin pump is integrated with a blood glucose monitoring device to create a more portable and compact system for use by persons with diabetes. The embodiments can have the following characteristics, the first being a microprocessor which controls both the insulin delivery system and the blood glucose detection system, or a second type of device which has two completely separate subsystems for insulin delivery and blood glucose monitoring but which are housed in the same case. Each of these solutions can be coupled with various case configurations to support integrated sampling Sy stems and/or strip storage. The system could also support the necessary logic to link me blood glucose reading to an output which controls the insulin delivery of the pump to the patient.

The invention uses two categories of devices as noted above to solve the need for compact and discrete device for the treatment and monitoring of intensive therapy. By providing a feedback and software means to vary the insulin delivery to the patient based on the blood glucose reading, inputted exercise, and other factors, the diabetic patient is freed from many error-prone treatment determinations.

The integration of a blood glucose monitoring system and an insulin pump system can provide numerous benefits to the patient, one being the compact package, another the possibility of integrated algorithm, and still another the integrated sampling system and strip storage. These features provide portability and discreetness features not found in other devices and permit a possibility of a semiclosed loop system.

The various aspects of the invention disclosed herein can best be illustrated by reference to the drawings and the description thereof which follows.

Figure 1 shows insulin pump 5 with catheter connection 10 and catheters 15 incorporated in a case 20 which has blood glucose monitor 25, strip holder 30, and common display 35. The figure also shows the blood glucose monitor start button 40 and insulin pump dispensing selection button 45.

Figure 2 shows insulin pump 5 with catheter connection 10 and catheters 15 incorporated in a case 20 which has blood glucose monitor 25, strip holder 30, and common display 35. The figure also shows the blood glucose monitor start button 40 and insulin pump dispensing selection button 45. A sampling system 50 used to extract a small sample of capillary blood is built into the unit and test strip 55 is used to collect and test the blood sample.

Figure 3 is a block diagram of the system components for a combined meter and insulin pump. Insulin pump 5 is comprised of microprocessor 100, metering pump 105 and indicator scales 110. The dispensing button 45 is used to set the dispensing rate and time increment of the insulin dose. The serial communication line 115 is used to connect the microprocessor 100 to the blood glucose meter microprocessor 200. The blood glucose meter 25 has a microprocessor 200 which runs the blood glucose meter and controls the common display 35. The blood glucose start button 40 provides for the initiation of the testing cycle used by the blood glucose monitor. The optics system 210 receives colormetric data from the test and converts it to electrical signal in the analog to digital circuit 215. The microprocessor 200 communicates with microprocessor 100 through the serial link 220. The serial link 220 permits the use of a common display 35.

Claims

Claims:
1. A combined blood glucose meter and insulin pump, comprising: a housing; a meter display visible from the outside of said housing; and at least one test strip that is stored in said housing.
2. The combined blood glucose meter and insulin pump of Claim 1, wherein the insulin settings are manually operated by the patient.
3. The combined blood glucose meter and insulin pump of Claim 1, wherein the insulin settings are calculated by an electronic system utilizing an algorithm.
4. The combined blood glucose meter and insulin pump of Claim 1, further comprising: a lancing system for obtaining the test specimen.
5. The combined blood glucose meter and insulin pump of Claim 3, wherein said electronic system utilizing an algorithm is a microprocessor.
6. The combined blood glucose meter and insulin pump of Claim 5, wherein said microprocessor controls the insulin delivery and the blood glucose detection.
7. The combined blood glucose meter and insulin pump of Claim 5, further comprising: software means to provide feedback to vary the insulin delivery based on the blood glucose reading.
8. The combined blood glucose meter and insulin pump of Claim 1, further comprising: a catheter connection to said housing.
9. The combined blood glucose meter and insulin pump of Claim 1, further comprising: an optics system to receive colorimetric data from the test sample.
PCT/US1999/020978 1998-09-11 1999-09-10 Device for determination of an analyte in a body fluid intergrated with an insulin pump WO2000013580A9 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US9989498 true 1998-09-11 1998-09-11
US60/099,894 1998-09-11

Publications (3)

Publication Number Publication Date
WO2000013580A1 true true WO2000013580A1 (en) 2000-03-16
WO2000013580A8 true WO2000013580A8 (en) 2000-06-02
WO2000013580A9 true WO2000013580A9 (en) 2000-08-10

Family

ID=22277137

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/020978 WO2000013580A9 (en) 1998-09-11 1999-09-10 Device for determination of an analyte in a body fluid intergrated with an insulin pump

Country Status (1)

Country Link
WO (1) WO2000013580A9 (en)

Cited By (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001013783A1 (en) * 1999-08-26 2001-03-01 Novartis Ag Ocular analyte sensor
WO2002028454A2 (en) * 2000-10-04 2002-04-11 Insulet Corporation Data collection assembly for patient infusion system
US6482186B1 (en) 1999-09-29 2002-11-19 Sterling Medivations, Inc. Reusable medication delivery device
FR2829941A1 (en) * 2001-09-21 2003-03-28 Soo Bong Choi Portable automatic insulin injector with blood sugar detection function
US6740059B2 (en) 2000-09-08 2004-05-25 Insulet Corporation Devices, systems and methods for patient infusion
US7041063B2 (en) 1996-09-04 2006-05-09 Marcio Marc Abreu Noninvasive measurement of chemical substances
US7187960B2 (en) 2002-04-22 2007-03-06 Marcio Marc Abreu Apparatus and method for measuring biologic parameters
US7276027B2 (en) 2001-02-06 2007-10-02 Roche Diagnostics Operations, Inc. System, for monitoring the concentration of analytes in body fluids
WO2010081219A1 (en) * 2009-01-13 2010-07-22 Fio Corporation A handheld diagnostic test device and method for use with an electronic device and a test cartridge in a rapid diagnostic test
US8328420B2 (en) 2003-04-22 2012-12-11 Marcio Marc Abreu Apparatus and method for measuring biologic parameters
US8771251B2 (en) 2009-12-17 2014-07-08 Hospira, Inc. Systems and methods for managing and delivering patient therapy through electronic drug delivery systems
US8849379B2 (en) 2002-04-22 2014-09-30 Geelux Holdings, Ltd. Apparatus and method for measuring biologic parameters
US9039975B2 (en) 2006-03-31 2015-05-26 Abbott Diabetes Care Inc. Analyte monitoring devices and methods therefor
US9042953B2 (en) 1998-04-30 2015-05-26 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US9066695B2 (en) 1998-04-30 2015-06-30 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US9066697B2 (en) 1998-04-30 2015-06-30 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US9066709B2 (en) 2009-01-29 2015-06-30 Abbott Diabetes Care Inc. Method and device for early signal attenuation detection using blood glucose measurements
US9078607B2 (en) 2005-11-01 2015-07-14 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US9445767B2 (en) 2005-10-24 2016-09-20 Geelux Holdings, Ltd. Apparatus and method for measuring biologic parameters
US9610034B2 (en) 2001-01-02 2017-04-04 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US9619625B2 (en) 2011-03-30 2017-04-11 Novo Nordisk A/S System for optimizing a patient's drug dosage regimen over time
US9649057B2 (en) 2007-05-08 2017-05-16 Abbott Diabetes Care Inc. Analyte monitoring system and methods
US9669162B2 (en) 2005-11-04 2017-06-06 Abbott Diabetes Care Inc. Method and system for providing basal profile modification in analyte monitoring and management systems
US9695482B2 (en) 2007-10-12 2017-07-04 Fio Coporation Flow focusing method and system for forming concentrated volumes of microbeads, and microbeads formed further thereto
US9730584B2 (en) 2003-06-10 2017-08-15 Abbott Diabetes Care Inc. Glucose measuring device for use in personal area network
US9743863B2 (en) 2006-03-31 2017-08-29 Abbott Diabetes Care Inc. Method and system for powering an electronic device
US9750439B2 (en) 2009-09-29 2017-09-05 Abbott Diabetes Care Inc. Method and apparatus for providing notification function in analyte monitoring systems
US9792809B2 (en) 2008-06-25 2017-10-17 Fio Corporation Bio-threat alert system
US9801545B2 (en) 2007-03-01 2017-10-31 Abbott Diabetes Care Inc. Method and apparatus for providing rolling data in communication systems
US9848815B2 (en) 2002-04-22 2017-12-26 Geelux Holdings, Ltd. Apparatus and method for measuring biologic parameters
US9945837B2 (en) 2008-08-29 2018-04-17 Fio Corporation Single-use handheld diagnostic test device, and an associated system and method for testing biological and environmental test samples
US9949678B2 (en) 2007-05-08 2018-04-24 Abbott Diabetes Care Inc. Method and device for determining elapsed sensor life
US9968302B2 (en) 2009-08-31 2018-05-15 Abbott Diabetes Care Inc. Analyte signal processing device and methods
US9968306B2 (en) 2012-09-17 2018-05-15 Abbott Diabetes Care Inc. Methods and apparatuses for providing adverse condition notification with enhanced wireless communication range in analyte monitoring systems
US9971871B2 (en) 2011-10-21 2018-05-15 Icu Medical, Inc. Medical device update system
US9980669B2 (en) 2011-11-07 2018-05-29 Abbott Diabetes Care Inc. Analyte monitoring device and methods
US9995611B2 (en) 2012-03-30 2018-06-12 Icu Medical, Inc. Air detection system and method for detecting air in a pump of an infusion system
US10042986B2 (en) 2013-11-19 2018-08-07 Icu Medical, Inc. Infusion pump automation system and method
US10046112B2 (en) 2013-05-24 2018-08-14 Icu Medical, Inc. Multi-sensor infusion system for detecting air or an occlusion in the infusion system

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8688188B2 (en) 1998-04-30 2014-04-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8346337B2 (en) 1998-04-30 2013-01-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
WO2002078512A8 (en) 2001-04-02 2004-12-02 Therasense Inc Blood glucose tracking apparatus and methods
US8771183B2 (en) 2004-02-17 2014-07-08 Abbott Diabetes Care Inc. Method and system for providing data communication in continuous glucose monitoring and management system
CA2580589C (en) 2006-12-19 2016-08-09 Fio Corporation Microfluidic detection system
US8930203B2 (en) 2007-02-18 2015-01-06 Abbott Diabetes Care Inc. Multi-function analyte test device and methods therefor
US8461985B2 (en) 2007-05-08 2013-06-11 Abbott Diabetes Care Inc. Analyte monitoring system and methods
US7928850B2 (en) 2007-05-08 2011-04-19 Abbott Diabetes Care Inc. Analyte monitoring system and methods
WO2010127050A1 (en) 2009-04-28 2010-11-04 Abbott Diabetes Care Inc. Error detection in critical repeating data in a wireless sensor system
EP2473099A4 (en) 2009-08-31 2015-01-14 Abbott Diabetes Care Inc Analyte monitoring system and methods for managing power and noise
US10022498B2 (en) 2011-12-16 2018-07-17 Icu Medical, Inc. System for monitoring and delivering medication to a patient and method of using the same to minimize the risks associated with automated therapy

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0098592A2 (en) * 1982-07-06 1984-01-18 Fujisawa Pharmaceutical Co., Ltd. Portable artificial pancreas
US4436094A (en) 1981-03-09 1984-03-13 Evreka, Inc. Monitor for continuous in vivo measurement of glucose concentration
US4704029A (en) 1985-12-26 1987-11-03 Research Corporation Blood glucose monitor
US4935346A (en) 1986-08-13 1990-06-19 Lifescan, Inc. Minimum procedure system for the determination of analytes
US5062841A (en) 1988-08-12 1991-11-05 The Regents Of The University Of California Implantable, self-regulating mechanochemical insulin pump
EP0255291B1 (en) 1986-07-23 1992-06-24 Unilever Plc Method and apparatus for electrochemical measurements
DE4234553A1 (en) * 1991-10-19 1993-04-22 Volker Frese Instrument for measuring blood glucose content - comprises storage container with test strips, colour scale and lancet with exchangeable needle
EP0351891B1 (en) 1983-05-05 1993-09-29 MediSense, Inc. Printed electrodes
US5391250A (en) 1994-03-15 1995-02-21 Minimed Inc. Method of fabricating thin film sensors
US5437999A (en) 1994-02-22 1995-08-01 Boehringer Mannheim Corporation Electrochemical sensor
EP0777123A2 (en) * 1994-03-09 1997-06-04 Thomas P. Castellano Medication delivery device with a microprocessor and characteristic monitor
US5665065A (en) * 1995-05-26 1997-09-09 Minimed Inc. Medication infusion device with blood glucose data input

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4436094A (en) 1981-03-09 1984-03-13 Evreka, Inc. Monitor for continuous in vivo measurement of glucose concentration
EP0098592A2 (en) * 1982-07-06 1984-01-18 Fujisawa Pharmaceutical Co., Ltd. Portable artificial pancreas
EP0351891B1 (en) 1983-05-05 1993-09-29 MediSense, Inc. Printed electrodes
US4704029A (en) 1985-12-26 1987-11-03 Research Corporation Blood glucose monitor
EP0255291B1 (en) 1986-07-23 1992-06-24 Unilever Plc Method and apparatus for electrochemical measurements
US4935346A (en) 1986-08-13 1990-06-19 Lifescan, Inc. Minimum procedure system for the determination of analytes
US5062841A (en) 1988-08-12 1991-11-05 The Regents Of The University Of California Implantable, self-regulating mechanochemical insulin pump
DE4234553A1 (en) * 1991-10-19 1993-04-22 Volker Frese Instrument for measuring blood glucose content - comprises storage container with test strips, colour scale and lancet with exchangeable needle
US5437999A (en) 1994-02-22 1995-08-01 Boehringer Mannheim Corporation Electrochemical sensor
EP0777123A2 (en) * 1994-03-09 1997-06-04 Thomas P. Castellano Medication delivery device with a microprocessor and characteristic monitor
US5391250A (en) 1994-03-15 1995-02-21 Minimed Inc. Method of fabricating thin film sensors
US5665065A (en) * 1995-05-26 1997-09-09 Minimed Inc. Medication infusion device with blood glucose data input

Cited By (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7809417B2 (en) 1996-09-04 2010-10-05 Marcio Marc Abreu Contact lens for collecting tears and detecting analytes for determining health status, ovulation detection, and diabetes screening
US7756559B2 (en) 1996-09-04 2010-07-13 Marcio Marc Abreu Device for generating a detectable signal based upon antibody/antigen interaction
US8774885B2 (en) 1996-09-04 2014-07-08 Geelux Holdings, Ltd. Device for generating a detectable signal based upon concentration of at least one substance
US7041063B2 (en) 1996-09-04 2006-05-09 Marcio Marc Abreu Noninvasive measurement of chemical substances
US9066697B2 (en) 1998-04-30 2015-06-30 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US9066694B2 (en) 1998-04-30 2015-06-30 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US9042953B2 (en) 1998-04-30 2015-05-26 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US9066695B2 (en) 1998-04-30 2015-06-30 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
WO2001013783A1 (en) * 1999-08-26 2001-03-01 Novartis Ag Ocular analyte sensor
US6850786B2 (en) 1999-08-26 2005-02-01 Novartis Ag Ocular analyte sensor
US6681127B2 (en) 1999-08-26 2004-01-20 Novartis Ag Ocular analyte sensor
US6482186B1 (en) 1999-09-29 2002-11-19 Sterling Medivations, Inc. Reusable medication delivery device
US6740059B2 (en) 2000-09-08 2004-05-25 Insulet Corporation Devices, systems and methods for patient infusion
WO2002028454A3 (en) * 2000-10-04 2002-07-18 Insulet Corp Data collection assembly for patient infusion system
WO2002028454A2 (en) * 2000-10-04 2002-04-11 Insulet Corporation Data collection assembly for patient infusion system
US9610034B2 (en) 2001-01-02 2017-04-04 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US7276027B2 (en) 2001-02-06 2007-10-02 Roche Diagnostics Operations, Inc. System, for monitoring the concentration of analytes in body fluids
US7403805B2 (en) 2001-02-23 2008-07-22 Marcio Marc Abreu Apparatus and method for noninvasive measurement of analytes from the conjunctiva using mid-infrared radiation
US8914089B2 (en) 2001-02-23 2014-12-16 Geelux Holdings, Ltd. Noninvasive measurement of chemical substances
FR2829941A1 (en) * 2001-09-21 2003-03-28 Soo Bong Choi Portable automatic insulin injector with blood sugar detection function
US8721562B2 (en) 2002-04-22 2014-05-13 Geelux Holdings, Ltd. Apparatus and method for measuring biologic parameters
US9011349B2 (en) 2002-04-22 2015-04-21 Geelux Holdings, Ltd. Apparatus and method for measuring biologic parameters
US9833150B2 (en) 2002-04-22 2017-12-05 Geelux Holdings, Ltd. Apparatus and method for measuring biologic parameters
US8849379B2 (en) 2002-04-22 2014-09-30 Geelux Holdings, Ltd. Apparatus and method for measuring biologic parameters
US9848815B2 (en) 2002-04-22 2017-12-26 Geelux Holdings, Ltd. Apparatus and method for measuring biologic parameters
US9408572B2 (en) 2002-04-22 2016-08-09 Geelux Holdings, Ltd. Apparatus and method for measuring biologic parameters
US10052030B2 (en) 2002-04-22 2018-08-21 Geelux Holdings, Ltd. Apparatus and method for measuring biologic parameters
US9398856B2 (en) 2002-04-22 2016-07-26 Geelux Holdings, Ltd. Thermal imaging system
US7187960B2 (en) 2002-04-22 2007-03-06 Marcio Marc Abreu Apparatus and method for measuring biologic parameters
US9301719B2 (en) 2002-04-22 2016-04-05 Geelux Holding, Ltd. Apparatus and method for measuring biologic parameters
US8328420B2 (en) 2003-04-22 2012-12-11 Marcio Marc Abreu Apparatus and method for measuring biologic parameters
US9730584B2 (en) 2003-06-10 2017-08-15 Abbott Diabetes Care Inc. Glucose measuring device for use in personal area network
US9445767B2 (en) 2005-10-24 2016-09-20 Geelux Holdings, Ltd. Apparatus and method for measuring biologic parameters
US9078607B2 (en) 2005-11-01 2015-07-14 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US9669162B2 (en) 2005-11-04 2017-06-06 Abbott Diabetes Care Inc. Method and system for providing basal profile modification in analyte monitoring and management systems
US9743863B2 (en) 2006-03-31 2017-08-29 Abbott Diabetes Care Inc. Method and system for powering an electronic device
US9625413B2 (en) 2006-03-31 2017-04-18 Abbott Diabetes Care Inc. Analyte monitoring devices and methods therefor
US9039975B2 (en) 2006-03-31 2015-05-26 Abbott Diabetes Care Inc. Analyte monitoring devices and methods therefor
US9801545B2 (en) 2007-03-01 2017-10-31 Abbott Diabetes Care Inc. Method and apparatus for providing rolling data in communication systems
US9649057B2 (en) 2007-05-08 2017-05-16 Abbott Diabetes Care Inc. Analyte monitoring system and methods
US9949678B2 (en) 2007-05-08 2018-04-24 Abbott Diabetes Care Inc. Method and device for determining elapsed sensor life
US9695482B2 (en) 2007-10-12 2017-07-04 Fio Coporation Flow focusing method and system for forming concentrated volumes of microbeads, and microbeads formed further thereto
US9792809B2 (en) 2008-06-25 2017-10-17 Fio Corporation Bio-threat alert system
US9945837B2 (en) 2008-08-29 2018-04-17 Fio Corporation Single-use handheld diagnostic test device, and an associated system and method for testing biological and environmental test samples
US9805165B2 (en) 2009-01-13 2017-10-31 Fio Corporation Handheld diagnostic test device and method for use with an electronic device and a test cartridge in a rapid diagnostic test
WO2010081219A1 (en) * 2009-01-13 2010-07-22 Fio Corporation A handheld diagnostic test device and method for use with an electronic device and a test cartridge in a rapid diagnostic test
US9066709B2 (en) 2009-01-29 2015-06-30 Abbott Diabetes Care Inc. Method and device for early signal attenuation detection using blood glucose measurements
US9968302B2 (en) 2009-08-31 2018-05-15 Abbott Diabetes Care Inc. Analyte signal processing device and methods
US9750439B2 (en) 2009-09-29 2017-09-05 Abbott Diabetes Care Inc. Method and apparatus for providing notification function in analyte monitoring systems
US8771251B2 (en) 2009-12-17 2014-07-08 Hospira, Inc. Systems and methods for managing and delivering patient therapy through electronic drug delivery systems
US9619625B2 (en) 2011-03-30 2017-04-11 Novo Nordisk A/S System for optimizing a patient's drug dosage regimen over time
US9971871B2 (en) 2011-10-21 2018-05-15 Icu Medical, Inc. Medical device update system
US9980669B2 (en) 2011-11-07 2018-05-29 Abbott Diabetes Care Inc. Analyte monitoring device and methods
US9995611B2 (en) 2012-03-30 2018-06-12 Icu Medical, Inc. Air detection system and method for detecting air in a pump of an infusion system
US9968306B2 (en) 2012-09-17 2018-05-15 Abbott Diabetes Care Inc. Methods and apparatuses for providing adverse condition notification with enhanced wireless communication range in analyte monitoring systems
US10046112B2 (en) 2013-05-24 2018-08-14 Icu Medical, Inc. Multi-sensor infusion system for detecting air or an occlusion in the infusion system
US10042986B2 (en) 2013-11-19 2018-08-07 Icu Medical, Inc. Infusion pump automation system and method

Also Published As

Publication number Publication date Type
WO2000013580A9 (en) 2000-08-10 application
WO2000013580A8 (en) 2000-06-02 application

Similar Documents

Publication Publication Date Title
US6123827A (en) Method for calibrating sensors used in diagnostic testing
US7162290B1 (en) Method and apparatus for blood glucose testing from a reversible infusion line
US4940945A (en) Interface circuit for use in a portable blood chemistry measuring apparatus
US5820622A (en) Analyte-controlled liquid delivery device and analyte monitor
US4929426A (en) Portable blood chemistry measuring apparatus
US7384396B2 (en) System and method for continuous analyte monitoring
US6275717B1 (en) Device and method of calibrating and testing a sensor for in vivo measurement of an analyte
US5237993A (en) Process and device for determining parameters of interest in living organisms
US5443080A (en) Integrated system for biological fluid constituent analysis
US7276027B2 (en) System, for monitoring the concentration of analytes in body fluids
US7147825B2 (en) Measuring system
US5266179A (en) Quantitative analysis method and its system using a disposable sensor
US20060091006A1 (en) Analyte sensor with insertion monitor, and methods
US20070239068A1 (en) Control solution packets and methods for calibrating bodily fluid sampling devices
US20080262334A1 (en) Method and device for predicting physiological values
US4787398A (en) Glucose medical monitoring system
US20050232815A1 (en) Body fluid testing device
US7914460B2 (en) Condensate glucose analyzer
EP0449525A1 (en) Medical diagnostic system
US20080283396A1 (en) Analyte Sensor with Insertion Monitor, and Methods
EP1256798A1 (en) Biosensor, measuring instrument for biosensor, and method of quantifying substrate
Updike et al. Laboratory evaluation of new reusable blood glucose sensor
US6066243A (en) Portable immediate response medical analyzer having multiple testing modules
Yamaguchi et al. Noninvasively measuring blood glucose using saliva
US5352411A (en) Device for determination of tear constituents

Legal Events

Date Code Title Description
AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

AK Designated states

Kind code of ref document: A1

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AL Designated countries for regional patents

Kind code of ref document: C1

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

CFP Corrected version of a pamphlet front page
CR1 Correction of entry in section i
AK Designated states

Kind code of ref document: C1

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: C2

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

AK Designated states

Kind code of ref document: C2

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW

COP Corrected version of pamphlet

Free format text: PAGES 1/3-3/3, DRAWINGS, REPLACED BY NEW PAGES 1/3-3/3; DUE TO LATE TRANSMITTAL BY THE RECEIVING OFFICE

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase