JP2006022108A5 - - Google Patents
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- Publication number
- JP2006022108A5 JP2006022108A5 JP2005217442A JP2005217442A JP2006022108A5 JP 2006022108 A5 JP2006022108 A5 JP 2006022108A5 JP 2005217442 A JP2005217442 A JP 2005217442A JP 2005217442 A JP2005217442 A JP 2005217442A JP 2006022108 A5 JP2006022108 A5 JP 2006022108A5
- Authority
- JP
- Japan
- Prior art keywords
- oxo
- pyrrolidinyl
- butanamide
- propyl
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- DNSISZSEWVHGLH-UHFFFAOYSA-N butanamide Chemical compound CCCC(N)=O DNSISZSEWVHGLH-UHFFFAOYSA-N 0.000 claims 19
- 150000001875 compounds Chemical class 0.000 claims 16
- -1 2,2-difluorovinyl Chemical group 0.000 claims 11
- 125000000217 alkyl group Chemical group 0.000 claims 8
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- 239000001257 hydrogen Substances 0.000 claims 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 208000006673 asthma Diseases 0.000 claims 4
- 206010015037 epilepsy Diseases 0.000 claims 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 208000020925 Bipolar disease Diseases 0.000 claims 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 2
- 208000019695 Migraine disease Diseases 0.000 claims 2
- 208000002193 Pain Diseases 0.000 claims 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 206010027599 migraine Diseases 0.000 claims 2
- 208000004296 neuralgia Diseases 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 2
- 229920002554 vinyl polymer Polymers 0.000 claims 2
- LYHWYWWLWAVRMW-YUMQZZPRSA-N (2s)-2-[(4r)-4-(iodomethyl)-2-oxopyrrolidin-1-yl]-n-methylbutanamide Chemical compound CNC(=O)[C@H](CC)N1C[C@H](CI)CC1=O LYHWYWWLWAVRMW-YUMQZZPRSA-N 0.000 claims 1
- HXSYUKBJWISQLD-MQWKRIRWSA-N (2s)-2-[2-oxo-4-(tetrazol-1-ylmethyl)pyrrolidin-1-yl]butanamide Chemical compound C1C(=O)N([C@@H](CC)C(N)=O)CC1CN1N=NN=C1 HXSYUKBJWISQLD-MQWKRIRWSA-N 0.000 claims 1
- UMWCSODNRCPYON-HACHORDNSA-N (2s)-2-[4-(2-iodopropyl)-2-oxopyrrolidin-1-yl]butanamide Chemical compound CC[C@@H](C(N)=O)N1CC(CC(C)I)CC1=O UMWCSODNRCPYON-HACHORDNSA-N 0.000 claims 1
- AODIMRJCLWXUFM-MQWKRIRWSA-N (2s)-2-[4-(isothiocyanatomethyl)-2-oxopyrrolidin-1-yl]butanamide Chemical compound CC[C@@H](C(N)=O)N1CC(CN=C=S)CC1=O AODIMRJCLWXUFM-MQWKRIRWSA-N 0.000 claims 1
- 125000004778 2,2-difluoroethyl group Chemical group [H]C([H])(*)C([H])(F)F 0.000 claims 1
- 125000004201 2,4-dichlorophenyl group Chemical group [H]C1=C([H])C(*)=C(Cl)C([H])=C1Cl 0.000 claims 1
- QXOVTMVRAFZVHN-UHFFFAOYSA-N 2-(2-oxo-4-propylpyrrolidin-1-yl)pent-4-enamide Chemical compound CCCC1CN(C(CC=C)C(N)=O)C(=O)C1 QXOVTMVRAFZVHN-UHFFFAOYSA-N 0.000 claims 1
- NLVDSLZEVKVXBN-UHFFFAOYSA-N 2-(4-ethynyl-2-oxopyrrolidin-1-yl)butanamide Chemical compound CCC(C(N)=O)N1CC(C#C)CC1=O NLVDSLZEVKVXBN-UHFFFAOYSA-N 0.000 claims 1
- 125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 claims 1
- 125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 claims 1
- 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims 1
- 125000006201 3-phenylpropyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 206010052613 Allergic bronchitis Diseases 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 201000006474 Brain Ischemia Diseases 0.000 claims 1
- 206010066091 Bronchial Hyperreactivity Diseases 0.000 claims 1
- 208000009079 Bronchial Spasm Diseases 0.000 claims 1
- 208000014181 Bronchial disease Diseases 0.000 claims 1
- 206010006482 Bronchospasm Diseases 0.000 claims 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 1
- 206010008111 Cerebral haemorrhage Diseases 0.000 claims 1
- 206010008120 Cerebral ischaemia Diseases 0.000 claims 1
- 208000000094 Chronic Pain Diseases 0.000 claims 1
- 208000022497 Cocaine-Related disease Diseases 0.000 claims 1
- 206010010741 Conjunctivitis Diseases 0.000 claims 1
- 206010010904 Convulsion Diseases 0.000 claims 1
- 206010013654 Drug abuse Diseases 0.000 claims 1
- 206010026749 Mania Diseases 0.000 claims 1
- 208000016285 Movement disease Diseases 0.000 claims 1
- 208000008238 Muscle Spasticity Diseases 0.000 claims 1
- 208000002033 Myoclonus Diseases 0.000 claims 1
- 229910002651 NO3 Inorganic materials 0.000 claims 1
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- 208000025966 Neurological disease Diseases 0.000 claims 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- MPRPZCNJUPQRGV-PYMCNQPYSA-N [1-[(2s)-1-amino-1-oxobutan-2-yl]-5-oxopyrrolidin-3-yl]methyl 4-methylbenzenesulfonate Chemical compound C1C(=O)N([C@@H](CC)C(N)=O)CC1COS(=O)(=O)C1=CC=C(C)C=C1 MPRPZCNJUPQRGV-PYMCNQPYSA-N 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 230000000172 allergic effect Effects 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 206010003119 arrhythmia Diseases 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims 1
- 125000005279 aryl sulfonyloxy group Chemical group 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- 150000001540 azides Chemical group 0.000 claims 1
- 230000036427 bronchial hyperreactivity Effects 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 206010008118 cerebral infarction Diseases 0.000 claims 1
- 201000001272 cocaine abuse Diseases 0.000 claims 1
- 230000036461 convulsion Effects 0.000 claims 1
- 201000006517 essential tremor Diseases 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- WMCFGPHWGVXGOY-UHFFFAOYSA-N hexanoic acid;hydrochloride Chemical compound Cl.CCCCCC(O)=O WMCFGPHWGVXGOY-UHFFFAOYSA-N 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 208000030603 inherited susceptibility to asthma Diseases 0.000 claims 1
- 150000002540 isothiocyanates Chemical class 0.000 claims 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 claims 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- 125000001893 nitrooxy group Chemical group [O-][N+](=O)O* 0.000 claims 1
- XDRYMKDFEDOLFX-UHFFFAOYSA-N pentamidine Chemical compound C1=CC(C(=N)N)=CC=C1OCCCCCOC1=CC=C(C(N)=N)C=C1 XDRYMKDFEDOLFX-UHFFFAOYSA-N 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- QLNJFJADRCOGBJ-UHFFFAOYSA-N propionamide Chemical compound CCC(N)=O QLNJFJADRCOGBJ-UHFFFAOYSA-N 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- 206010039083 rhinitis Diseases 0.000 claims 1
- 208000018198 spasticity Diseases 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0004297.8A GB0004297D0 (en) | 2000-02-23 | 2000-02-23 | 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses |
| GB0004297.8 | 2000-02-23 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001561734A Division JP4121744B2 (ja) | 2000-02-23 | 2001-02-21 | ２−オキソ−１−ピロリジン誘導体、それらの製造方法及びそれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006022108A JP2006022108A (ja) | 2006-01-26 |
| JP2006022108A5 true JP2006022108A5 (OSRAM) | 2008-03-13 |
| JP4938259B2 JP4938259B2 (ja) | 2012-05-23 |
Family
ID=9886259
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001561734A Expired - Lifetime JP4121744B2 (ja) | 2000-02-23 | 2001-02-21 | ２−オキソ−１−ピロリジン誘導体、それらの製造方法及びそれらの使用 |
| JP2001563480A Expired - Fee Related JP4081275B2 (ja) | 2000-02-23 | 2001-02-21 | ２−オキソ−１−ピロリジン誘導体、それらの製造法、およびそれらの使用 |
| JP2005217433A Pending JP2006022107A (ja) | 2000-02-23 | 2005-07-27 | ２−オキソ−１−ピロリジン誘導体、それらの製造方法及びそれらの使用 |
| JP2005217442A Expired - Lifetime JP4938259B2 (ja) | 2000-02-23 | 2005-07-27 | ２−オキソ−１−ピロリジン誘導体、それらの製造方法及びそれらの使用 |
| JP2007102379A Expired - Fee Related JP4769756B2 (ja) | 2000-02-23 | 2007-04-10 | ２−オキソ−１−ピロリジン誘導体、それらの製造法、およびそれらの使用 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001561734A Expired - Lifetime JP4121744B2 (ja) | 2000-02-23 | 2001-02-21 | ２−オキソ−１−ピロリジン誘導体、それらの製造方法及びそれらの使用 |
| JP2001563480A Expired - Fee Related JP4081275B2 (ja) | 2000-02-23 | 2001-02-21 | ２−オキソ−１−ピロリジン誘導体、それらの製造法、およびそれらの使用 |
| JP2005217433A Pending JP2006022107A (ja) | 2000-02-23 | 2005-07-27 | ２−オキソ−１−ピロリジン誘導体、それらの製造方法及びそれらの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007102379A Expired - Fee Related JP4769756B2 (ja) | 2000-02-23 | 2007-04-10 | ２−オキソ−１−ピロリジン誘導体、それらの製造法、およびそれらの使用 |
Country Status (43)
Families Citing this family (166)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7365093B2 (en) * | 1994-08-19 | 2008-04-29 | Abbott Laboratories | Endothelin antagonists |
| GB0004297D0 (en) * | 2000-02-23 | 2000-04-12 | Ucb Sa | 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses |
| US6686477B2 (en) * | 2000-09-29 | 2004-02-03 | Eastman Chemical Company | Highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using same |
| US20040116505A1 (en) * | 2001-02-23 | 2004-06-17 | Gregory Krauss | Treatment of tics, tremors and related disorders |
| AU2002329233B2 (en) * | 2001-08-10 | 2007-08-16 | Ucb Pharma | Oxopyrrolidine compounds, preparation of said compounds and their use in the manufacturing of levetiracetam and analogues |
| HUP0401667A2 (hu) * | 2001-10-08 | 2004-12-28 | Ucb, S.A. | 2-Oxo-1-pirrolidin-származékok alkalmazása diszkinézia és mozgási rendellenességek kezelésére szolgáló gyógyszer előállítására |
| ATE444065T1 (de) | 2001-10-16 | 2009-10-15 | Memory Pharm Corp | 4(4-alkoxy-3-hydroxyphenyl)-2-pyrrolidon-deriva e als pde-4-hemmer zur behandlung von neurologischen syndromen |
| AU2003242538A1 (en) * | 2002-05-14 | 2003-11-11 | Ucb, S.A. | Use of 2-oxo-1-pyrrolidone derivatives for the preparation of a drug |
| EP1587620B1 (en) | 2003-01-13 | 2009-09-09 | UCB Pharma, S.A. | Hydrogenation catalysts |
| WO2004069796A2 (en) * | 2003-02-03 | 2004-08-19 | Teva Pharmaceutical Industries Ltd. | Process for producing levetiracetam |
| ES2214147B1 (es) | 2003-02-28 | 2005-10-01 | Farma-Lepori S.A. | Procedimiento de obtencion de un agente antiepileptico. |
| TR200503397T1 (tr) * | 2003-03-18 | 2007-03-21 | Hetero Drugs Limited | Levetirasetam'ın yeni kristal formları. |
| RU2232578C1 (ru) * | 2003-04-10 | 2004-07-20 | Ахапкина Валентина Ивановна | Вещество, обладающее антидепрессивной активностью |
| WO2004094375A2 (en) | 2003-04-16 | 2004-11-04 | Memory Pharmaceuticals Corporation | 4 - (3,4 - disubstituted phenyl) - pyrrolidin-2-one compounds as phosphodiesterase 4 inhibitors |
| US7034051B2 (en) * | 2003-08-28 | 2006-04-25 | Adolor Corporation | Fused bicyclic carboxamide derivatives and methods of their use |
| EP1663968A1 (en) * | 2003-09-05 | 2006-06-07 | Ranbaxy Laboratories Limited | Process for the preparation of pure levetiracetam |
| US7629474B2 (en) | 2003-09-24 | 2009-12-08 | Ucb Pharma S.A. | Process for preparing 2-oxo-1-pyrrolidine derivatives |
| EA010031B1 (ru) * | 2003-12-02 | 2008-06-30 | Юсб, С.А. | Производные имидазола, способы их получения и применения |
| ZA200610274B (en) * | 2004-06-11 | 2008-06-25 | Ucb Sa | Process for preparing 2-oxo-1-pyrrolidine derivatives by intramolecular allylation |
| SI1831154T1 (sl) * | 2004-06-21 | 2010-03-31 | Warner Lambert Co | Priprava pregabalina in sorodnih spojin |
| US7427601B2 (en) * | 2004-06-24 | 2008-09-23 | Schwarz Pharma Ag | Method for treating tremor |
| US7585882B2 (en) | 2004-10-20 | 2009-09-08 | Memory Pharmaceuticals Corporation | Phosphodiesterase 4 inhibitors |
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| EP1912966A2 (en) | 2005-06-01 | 2008-04-23 | Ucb, S.A. | 2-oxo-1-pyrrolidine derivatives and their therapeutic use on the central nervous system |
| EP1731149A1 (en) * | 2005-06-08 | 2006-12-13 | Ucb S.A. | Use of 2-oxo-1-pyrrolidone derivatives for the treatment of diseases characterized by progressive myoclonic epilepsy |
| US8957226B2 (en) * | 2005-09-15 | 2015-02-17 | Ucb Pharma S.A. | 2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses |
| JP2007153755A (ja) * | 2005-12-01 | 2007-06-21 | Gifu Univ | プロリン類縁体 |
| AU2006322297A1 (en) * | 2005-12-07 | 2007-06-14 | Ucb Pharma, S.A. | 3-carboxy- 2-oxo-1 -pyrrolidine derivatives and their uses |
| US8338621B2 (en) | 2005-12-21 | 2012-12-25 | Ucb S.A. | Process for the preparation of 2-oxo-1-pyrrolidine derivatives |
| LV13630B (en) * | 2006-03-16 | 2007-12-20 | Olainfarm As | Method of preparation and use of pharmaceutically active n-carbamoylmethyl-4(r)-phenyl-2-pyrrolidinone |
| BRPI0712325A2 (pt) * | 2006-06-08 | 2012-01-10 | Ucb Pharma Sa | processo para a preparação de co-cristais de pirrolidinonas, co-cristal, composição farmacêutica, e, uso de um co-cristal |
| EP2037965B1 (en) * | 2006-06-15 | 2017-08-30 | UCB Pharma GmbH | Pharmaceutical composition with synergistic anticonvulsant effect |
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| SI2076508T1 (sl) * | 2006-10-18 | 2011-04-29 | Pfizer Prod Inc | Spojine biaril eter sečnine |
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| WO2008132139A2 (en) * | 2007-04-27 | 2008-11-06 | Ucb Pharma S.A. | New heterocyclic derivatives useful for the treatment of cns disorders |
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| EP2273975B8 (en) * | 2008-03-03 | 2014-12-17 | UCB Pharma, S.A. | Pharmaceutical solutions, process of preparation and therapeutic uses |
| US7741327B2 (en) * | 2008-04-16 | 2010-06-22 | Hoffmann-La Roche Inc. | Pyrrolidinone glucokinase activators |
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| HUE032275T2 (en) * | 2008-11-18 | 2017-09-28 | Ucb Biopharma Sprl | Sustained release formulations containing a 2-oxo-pyrrolidine derivative |
| MX356281B (es) * | 2008-11-18 | 2018-05-22 | Ucb Pharma Sa | Formulaciones de liberacion prolongada que comprenden un derivado de 2-oxo-1-pirrolidina. |
| FR2939311A1 (fr) * | 2008-12-08 | 2010-06-11 | Oreal | Utilisation d'un derive diester de pyrrolidinone 4-carboxy comme solvant dans les compositions cosmetiques ; compositions cosmetiques les contenant |
| WO2010089372A1 (en) | 2009-02-09 | 2010-08-12 | Ucb Pharma, S.A. | Pharmaceutical compositions comprising brivaracetam |
| US8846411B2 (en) * | 2009-06-11 | 2014-09-30 | Microgenics Corporation | Derivatives, reagents, and immunoassay for detecting levetiracetam |
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| US7939676B2 (en) | 2009-09-17 | 2011-05-10 | Zach System S.P.A. | Process for the preparation of levetiracetam |
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| PE20121562A1 (es) | 2009-10-23 | 2012-11-30 | Ucb Pharma Sa | Derivados de 2-oxo-1-pirrolidinila imidazotiadiazol |
| PL389364A1 (pl) | 2009-10-23 | 2011-04-26 | Uniwersytet Jagielloński | Nowe zastosowanie pochodnych 2-pirolidonu |
| CN109662964A (zh) | 2010-02-09 | 2019-04-23 | 约翰斯.霍普金斯大学 | 用于改善认知功能的方法和组合物 |
| FR2961099B1 (fr) | 2010-06-09 | 2012-06-15 | Oreal | Derives de 2-pyrrolidone fonctionnalisee par un radical ester, acide ou amide, la composition cosmetique les comprenant et leur utilisation pour le conditionnement des matieres keratiniques |
| FR2961101B1 (fr) | 2010-06-09 | 2013-01-25 | Oreal | Composition comprenant au moins une 2-pyrrolidone fonctionnalisee par un radical ester ou amide, et au moins un pigment ou un colorant direct pour la teinture des matieres keratiniques |
| FR2961098A1 (fr) | 2010-06-09 | 2011-12-16 | Oreal | Composition comprenant au moins une 2-pyrrolidone fonctionnalisee en position 4 par un acide carboxylique ou amide, et au moins un colorant direct ou un pigment pour la teinture des fibres keratiniques |
| US8466297B2 (en) | 2010-11-01 | 2013-06-18 | Milan Soukup | Manufacturing process for (S)-Pregabalin |
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| AU2012214303A1 (en) * | 2011-02-09 | 2013-09-12 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
| SI2699581T1 (sl) | 2011-04-18 | 2016-02-29 | Ucb Biopharma Sprl | Derivati 2-okso-1-imidazolidinil imidazotiadiazola |
| IN2014CN03043A (OSRAM) | 2011-09-30 | 2015-07-03 | Univ Tufts | |
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- 2001-02-21 RU RU2002124522A patent/RU2291860C3/ru active
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- 2001-02-21 CN CNA2005100999539A patent/CN1740150A/zh active Pending
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- 2001-02-21 CN CNA2005100999524A patent/CN1740151A/zh active Pending
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2002
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2003
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2004
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2005
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- 2005-08-09 IL IL170181A patent/IL170181A/en active Protection Beyond IP Right Term
- 2005-08-11 RU RU2005125569/04A patent/RU2005125569A/ru not_active Application Discontinuation
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- 2005-09-16 BG BG109297A patent/BG65803B1/bg unknown
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2006
- 2006-07-28 CY CY20061101045T patent/CY1105517T1/el unknown
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2007
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2010
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2011
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2016
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- 2016-03-09 BE BE2016C012C patent/BE2016C012I2/fr unknown
- 2016-03-11 LU LU92993C patent/LU92993I2/xx unknown
- 2016-04-13 HU HUS1600017C patent/HUS1600017I1/hu unknown
- 2016-05-04 LT LTPA2016013C patent/LTC1265862I2/lt unknown
- 2016-05-25 FR FR16C1001C patent/FR16C1001I2/fr active Active
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- 2016-06-30 CY CY2016022C patent/CY2016022I1/el unknown
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2023
- 2023-06-20 NO NO2023025C patent/NO2023025I1/no unknown
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