|
US4911920A
(en)
*
|
1986-07-30 |
1990-03-27 |
Alcon Laboratories, Inc. |
Sustained release, comfort formulation for glaucoma therapy
|
|
FR2588189B1
(fr)
*
|
1985-10-03 |
1988-12-02 |
Merck Sharp & Dohme |
Composition pharmaceutique de type a transition de phase liquide-gel
|
|
US4902505A
(en)
|
1986-07-30 |
1990-02-20 |
Alkermes |
Chimeric peptides for neuropeptide delivery through the blood-brain barrier
|
|
US4801575A
(en)
*
|
1986-07-30 |
1989-01-31 |
The Regents Of The University Of California |
Chimeric peptides for neuropeptide delivery through the blood-brain barrier
|
|
US5624898A
(en)
*
|
1989-12-05 |
1997-04-29 |
Ramsey Foundation |
Method for administering neurologic agents to the brain
|
|
US6407061B1
(en)
*
|
1989-12-05 |
2002-06-18 |
Chiron Corporation |
Method for administering insulin-like growth factor to the brain
|
|
JP2594486B2
(ja)
*
|
1991-01-15 |
1997-03-26 |
アルコン ラボラトリーズ インコーポレイテッド |
局所的眼薬組成物
|
|
US5212162A
(en)
*
|
1991-03-27 |
1993-05-18 |
Alcon Laboratories, Inc. |
Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions
|
|
US6287792B1
(en)
*
|
1991-06-17 |
2001-09-11 |
The Regents Of The University Of California |
Drug delivery of antisense oligonucleotides and peptides to tissues in vivo and to cells using avidin-biotin technology
|
|
TW282460B
(OSRAM)
|
1993-12-28 |
1996-08-01 |
Yamanouchi Pharma Co Ltd |
|
|
US6309853B1
(en)
|
1994-08-17 |
2001-10-30 |
The Rockfeller University |
Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
|
|
US5728718A
(en)
*
|
1994-12-20 |
1998-03-17 |
The United States Of America As Represented By The Department Of Health And Human Services |
2,5-diamino-3,4-disubstituted-1,6-diphenylhexane isosteres comprising benzamide, sulfonamide and anthranilamide subunits and methods of using same
|
|
DE60045005D1
(de)
*
|
1999-06-28 |
2010-11-04 |
Oklahoma Med Res Found |
Inhibitoren des memapsin 2 und ihre verwendung
|
|
EP1237872B1
(en)
*
|
1999-12-16 |
2008-02-27 |
Emisphere Technologies, Inc. |
Compounds and compositions for delivering active agents
|
|
JP2004528266A
(ja)
*
|
2000-04-12 |
2004-09-16 |
インプリクス リミテッド |
薬物送達用組成物
|
|
US6372250B1
(en)
*
|
2000-04-25 |
2002-04-16 |
The Regents Of The University Of California |
Non-invasive gene targeting to the brain
|
|
WO2002002506A2
(en)
|
2000-06-30 |
2002-01-10 |
Elan Pharmaceuticals, Inc. |
Compounds to treat alzheimer's disease
|
|
PE20020276A1
(es)
*
|
2000-06-30 |
2002-04-06 |
Elan Pharm Inc |
COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER
|
|
US6846813B2
(en)
|
2000-06-30 |
2005-01-25 |
Pharmacia & Upjohn Company |
Compounds to treat alzheimer's disease
|
|
US20040121947A1
(en)
*
|
2000-12-28 |
2004-06-24 |
Oklahoma Medical Research Foundation |
Compounds which inhibit beta-secretase activity and methods of use thereof
|
|
US20030092629A1
(en)
|
2000-12-28 |
2003-05-15 |
Oklahoma Medical Research Foundation |
Inhibitors of memapsin 2 and use thereof
|
|
AU2002248432A1
(en)
|
2001-02-14 |
2002-08-28 |
Sankyo Company, Limited |
Oxazole derivatives, their preparation and their use as cytokine inhibitors
|
|
US20060234944A1
(en)
*
|
2001-10-23 |
2006-10-19 |
Oklahoma Medical Reseach Foundation |
Beta-secretase inhibitors and methods of use
|
|
WO2003039454A2
(en)
|
2001-10-23 |
2003-05-15 |
Oklahoma Medical Research Foundation |
Beta-secretase inhibitors and methods of use
|
|
IL161881A0
(en)
|
2001-11-08 |
2005-11-20 |
Upjohn Co |
N,N'-substituted-1,3-diamino-2-hydroxypropane derivatives
|
|
CA2469622A1
(en)
*
|
2001-12-06 |
2003-06-19 |
Elan Pharmaceuticals, Inc. |
Substituted hydroxyethylamines
|
|
CN101090883A
(zh)
|
2002-02-27 |
2007-12-19 |
艾伦药物公司 |
取代羟基乙胺
|
|
US7807618B2
(en)
*
|
2002-05-20 |
2010-10-05 |
The Board Of Regents Of The University Of Texas System |
Methods and compositions for delivering enzymes and nucleic acid molecules to brain, bone and other tissues
|
|
CN1732161A
(zh)
|
2002-09-06 |
2006-02-08 |
艾伦药物公司 |
1,3-二氨基-2-羟基丙烷前体药物衍生物
|
|
ATE443043T1
(de)
*
|
2002-11-12 |
2009-10-15 |
Merck & Co Inc |
Phenylcarboxamide als beta-sekretase-hemmer zur behandlung von alzheimer
|
|
US7388079B2
(en)
*
|
2002-11-27 |
2008-06-17 |
The Regents Of The University Of California |
Delivery of pharmaceutical agents via the human insulin receptor
|
|
US20040102369A1
(en)
*
|
2002-11-27 |
2004-05-27 |
The Regents Of The University Of California |
Transport of basic fibroblast growth factor across the blood brain barrier
|
|
GB0228410D0
(en)
*
|
2002-12-05 |
2003-01-08 |
Glaxo Group Ltd |
Novel Compounds
|
|
GB0305918D0
(en)
|
2003-03-14 |
2003-04-23 |
Glaxo Group Ltd |
Novel compounds
|
|
JP4448134B2
(ja)
*
|
2003-08-08 |
2010-04-07 |
シェーリング コーポレイション |
ベンズアミド置換基を有する環状アミンbase−1阻害剤
|
|
KR100793095B1
(ko)
|
2003-10-01 |
2008-01-10 |
주식회사 프로메디텍 |
Bace 저해효능을 가진 신규한 술폰 아미드 유도체
|
|
AU2004311749A1
(en)
|
2003-12-19 |
2005-07-21 |
Merck & Co., Inc. |
Phenylamide and pyridylamide beta-secretase inhibitors for the treatment of Alzheimer's disease
|
|
EP1740575A2
(en)
|
2004-04-22 |
2007-01-10 |
Eli Lilly And Company |
Pyrrolidine derivatives useful as bace inhibitors
|
|
US7585885B2
(en)
*
|
2004-04-22 |
2009-09-08 |
Eli Lilly And Company |
Pyrrolidine derivatives useful as BACE inhibitors
|
|
EP1758854B1
(en)
|
2004-06-15 |
2014-07-16 |
Merck Sharp & Dohme Corp. |
Pyrrolidin-3-yl compounds useful as beta-secretase inhibitors for the treatment of alzheimer's disease
|
|
US8436006B2
(en)
*
|
2004-08-06 |
2013-05-07 |
Jansssen Pharmaceutica N.V. |
2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
|
|
US20080207527A1
(en)
*
|
2004-09-17 |
2008-08-28 |
Comentis, Inc. |
Bicyclic Compounds Which Inhibit Beta-Secretase Activity and Methods of Use Thereof
|
|
JP2008513497A
(ja)
*
|
2004-09-17 |
2008-05-01 |
コメンティス,インコーポレーテッド |
メマプシン2βセクレターゼ活性を阻害するアミノ含有化合物およびその使用方法
|
|
CN100475786C
(zh)
*
|
2005-02-18 |
2009-04-08 |
中国科学院上海药物研究所 |
一类4-羟基戊酰胺类化合物及其制备方法和用途
|
|
WO2006099352A1
(en)
|
2005-03-10 |
2006-09-21 |
Bristol-Myers Squibb Company |
Novel isophthalates as beta-secretase inhibitors
|
|
CA2604291A1
(en)
*
|
2005-04-08 |
2006-10-19 |
Comentis, Inc. |
Compounds which inhibit beta-secretase activity and methods of use thereof
|
|
MY144968A
(en)
|
2005-04-11 |
2011-11-30 |
Xenon Pharmaceuticals Inc |
Spiro-oxindole compounds and their uses as therapeutic agents
|
|
AR054363A1
(es)
|
2005-05-23 |
2007-06-20 |
Astrazeneca Ab |
Compuestos que exhiben actividad moduladora en el receptor 5-hidroxi-triptamina 6
|
|
AR054044A1
(es)
|
2005-05-23 |
2007-05-30 |
Astrazeneca Ab |
Derivados de cromano y tetrahidronaftaleno como moduladores del receptor 5 - ht6; intermediarios en su preparacion; composiciones farmaceuticas que los contienen y su empelo en la fabricacion de medicamentos para el tratamiento de enfermedades del snc y de la obesidad.
|
|
GB0513886D0
(en)
|
2005-07-06 |
2005-08-10 |
Glaxo Group Ltd |
Novel compounds
|
|
US7476764B2
(en)
*
|
2005-08-04 |
2009-01-13 |
Bristol-Myers Squibb Company |
Phenylcarboxyamides as beta-secretase inhibitors
|
|
US7790745B2
(en)
|
2005-10-21 |
2010-09-07 |
Bristol-Myers Squibb Company |
Tetrahydroisoquinoline LXR Modulators
|
|
TW200804290A
(en)
|
2005-11-15 |
2008-01-16 |
Astrazeneca Ab |
Compounds and uses thereof
|
|
EP2077719B1
(en)
|
2006-09-21 |
2011-12-28 |
Merck Sharp & Dohme Corp. |
Piperidine and pyrrolidine beta-secretase inhibitors for the treatment of alzheimer's disease
|
|
KR20100051668A
(ko)
|
2007-07-26 |
2010-05-17 |
코멘티스, 인코포레이티드 |
베타-세크레타제 활성을 억제하는 이소프탈아미드 유도체
|
|
MX2010002938A
(es)
|
2007-09-24 |
2010-04-01 |
Comentis Inc |
Derivados de (3-hidroxi-4-amino-butan-2-il)-3-(2-tiazol-2-il-pirro lidin-1-carbonil)benzamida y compuestos relacionados como inhibidores de beta-secretasa para tratar enfermedad de alzheimer.
|
|
EP2307345A4
(en)
|
2008-07-01 |
2012-05-02 |
Purdue Research Foundation |
NON-PEPTIDINHIBITORS OF HIV-1 PROTEASE
|
|
JP2012505241A
(ja)
|
2008-10-10 |
2012-03-01 |
パーデュー・リサーチ・ファウンデーション |
アルツハイマー病の治療用組成物
|
|
EP2349244A4
(en)
|
2008-10-10 |
2012-09-19 |
Comentis Inc |
PYRROLIDINE COMPOUNDS THAT PREVENT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF
|
|
US8394807B2
(en)
|
2008-11-20 |
2013-03-12 |
Purdue Research Foundation |
Quinazoline inhibitors of BACE 1 and methods of using
|
|
US8859590B2
(en)
|
2008-12-05 |
2014-10-14 |
Purdue Research Foundation |
Inhibitors of BACE1 and methods for treating Alzheimer's disease
|
|
US20120214802A1
(en)
|
2009-03-25 |
2012-08-23 |
Bilcer Geoffrey M |
Pyrrolidine compounds which inhibit beta-secretase activity and methods of use thereof
|
|
WO2011044057A1
(en)
|
2009-10-05 |
2011-04-14 |
Comentis, Inc. |
Sulfonamido pyrrolidine compounds which inhibit beta-secretase activity and methods of use thereof
|