MX2010002938A - Derivados de (3-hidroxi-4-amino-butan-2-il)-3-(2-tiazol-2-il-pirro lidin-1-carbonil)benzamida y compuestos relacionados como inhibidores de beta-secretasa para tratar enfermedad de alzheimer. - Google Patents
Derivados de (3-hidroxi-4-amino-butan-2-il)-3-(2-tiazol-2-il-pirro lidin-1-carbonil)benzamida y compuestos relacionados como inhibidores de beta-secretasa para tratar enfermedad de alzheimer.Info
- Publication number
- MX2010002938A MX2010002938A MX2010002938A MX2010002938A MX2010002938A MX 2010002938 A MX2010002938 A MX 2010002938A MX 2010002938 A MX2010002938 A MX 2010002938A MX 2010002938 A MX2010002938 A MX 2010002938A MX 2010002938 A MX2010002938 A MX 2010002938A
- Authority
- MX
- Mexico
- Prior art keywords
- treating
- beta
- butan
- thiazol
- pyrrolidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97479307P | 2007-09-24 | 2007-09-24 | |
| PCT/US2008/077537 WO2009042694A1 (en) | 2007-09-24 | 2008-09-24 | (3-hydroxy-4-amino-butan-2-yl) -3- (2-thiazol-2-yl-pyrrolidine-1-carbonyl) benzamide derivatives and related compounds as beta-secretase inhibitors for treating |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2010002938A true MX2010002938A (es) | 2010-04-01 |
Family
ID=40343545
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010002938A MX2010002938A (es) | 2007-09-24 | 2008-09-24 | Derivados de (3-hidroxi-4-amino-butan-2-il)-3-(2-tiazol-2-il-pirro lidin-1-carbonil)benzamida y compuestos relacionados como inhibidores de beta-secretasa para tratar enfermedad de alzheimer. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8299267B2 (OSRAM) |
| EP (1) | EP2205596A1 (OSRAM) |
| JP (1) | JP5055432B2 (OSRAM) |
| KR (1) | KR20100059919A (OSRAM) |
| CN (1) | CN101868457B (OSRAM) |
| CA (1) | CA2699787A1 (OSRAM) |
| MX (1) | MX2010002938A (OSRAM) |
| WO (1) | WO2009042694A1 (OSRAM) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2205596A1 (en) | 2007-09-24 | 2010-07-14 | Comentis, Inc. | (3-hydroxy-4-amino-butan-2-yl) -3- (2-thiazol-2-yl-pyrrolidine-1-carbonyl) benzamide derivatives and related compounds as beta-secretase inhibitors for treating |
| WO2011028288A1 (en) * | 2009-09-04 | 2011-03-10 | Tactical Therapeutics, Inc | Novel compositions and processes for preparing 5-amino or substituted amino 1,2,3-triazoles and triazole orotate formulations |
| CN102695546B (zh) | 2009-09-11 | 2014-09-10 | 前体生物药物股份公司 | 作为谷氨酰胺酰环化酶抑制剂的杂环衍生物 |
| EP2486006A4 (en) * | 2009-10-05 | 2013-05-01 | Comentis Inc | SULFONAMIDO PYRROLIDINE COMPOUNDS THAT INHIBIT BETA SECRETASE ACTIVITY AND METHODS OF USE THEREOF |
| WO2012027495A1 (en) | 2010-08-27 | 2012-03-01 | University Of The Pacific | Piperazinylpyrimidine analogues as protein kinase inhibitors |
| US20120053200A1 (en) * | 2010-09-01 | 2012-03-01 | Harald Mauser | Bace 2 inhibitors |
| KR20150021036A (ko) | 2012-06-14 | 2015-02-27 | 다이이찌 산쿄 가부시키가이샤 | 피페리디닐피라졸로피리딘 유도체 |
| CN105669365B (zh) * | 2016-03-04 | 2022-06-21 | 中国科学院上海有机化学研究所 | 含二氟烷基取代的芳基或杂芳基化合物、制备方法和应用 |
| PL3461819T3 (pl) | 2017-09-29 | 2020-11-30 | Probiodrug Ag | Inhibitory cyklazy glutaminylowej |
| CN110117237B (zh) * | 2018-02-05 | 2024-02-02 | 中国科学院上海有机化学研究所 | 一种芳香腈或烯基腈类化合物的制备方法 |
| CN110642789B (zh) * | 2019-11-25 | 2020-05-26 | 天津凯莱英制药有限公司 | 2-氯嘧啶-4-甲酸类化合物的连续性合成方法 |
| CN112321515A (zh) * | 2020-10-21 | 2021-02-05 | 上海馨远医药科技有限公司 | 一种手性1-叔丁基-3-甲基-6-甲基哌嗪-1,3-二甲酸酯的制备方法 |
| WO2023149945A1 (en) * | 2022-02-03 | 2023-08-10 | Purdue Research Foundation | Peptidomimetic inhibitors of protein n-terminal methyltransferase 1, composition, and method of use |
| US12191004B2 (en) | 2022-06-27 | 2025-01-07 | Microsoft Technology Licensing, Llc | Machine learning system with two encoder towers for semantic matching |
Family Cites Families (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4911920A (en) | 1986-07-30 | 1990-03-27 | Alcon Laboratories, Inc. | Sustained release, comfort formulation for glaucoma therapy |
| FR2588189B1 (fr) | 1985-10-03 | 1988-12-02 | Merck Sharp & Dohme | Composition pharmaceutique de type a transition de phase liquide-gel |
| US4902505A (en) | 1986-07-30 | 1990-02-20 | Alkermes | Chimeric peptides for neuropeptide delivery through the blood-brain barrier |
| US4801575A (en) | 1986-07-30 | 1989-01-31 | The Regents Of The University Of California | Chimeric peptides for neuropeptide delivery through the blood-brain barrier |
| US6407061B1 (en) | 1989-12-05 | 2002-06-18 | Chiron Corporation | Method for administering insulin-like growth factor to the brain |
| US5624898A (en) | 1989-12-05 | 1997-04-29 | Ramsey Foundation | Method for administering neurologic agents to the brain |
| EP0495421B1 (en) | 1991-01-15 | 1996-08-21 | Alcon Laboratories, Inc. | Use of carrageenans in topical ophthalmic compositions |
| US5212162A (en) | 1991-03-27 | 1993-05-18 | Alcon Laboratories, Inc. | Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions |
| US6287792B1 (en) | 1991-06-17 | 2001-09-11 | The Regents Of The University Of California | Drug delivery of antisense oligonucleotides and peptides to tissues in vivo and to cells using avidin-biotin technology |
| TW282460B (OSRAM) | 1993-12-28 | 1996-08-01 | Yamanouchi Pharma Co Ltd | |
| US6309853B1 (en) | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
| US5728718A (en) | 1994-12-20 | 1998-03-17 | The United States Of America As Represented By The Department Of Health And Human Services | 2,5-diamino-3,4-disubstituted-1,6-diphenylhexane isosteres comprising benzamide, sulfonamide and anthranilamide subunits and methods of using same |
| AU5773500A (en) | 1999-06-28 | 2001-01-31 | Board Of Trustees Of The University Of Illinois, The | Inhibitors of memapsin 2 and use thereof |
| DE60038183T2 (de) | 1999-12-16 | 2009-02-19 | Emisphere Technologies, Inc. | Verbindungen und zusammensetzungen zur abgabe aktiver wirkstoffe |
| EP1272222A2 (en) | 2000-04-12 | 2003-01-08 | Implyx Ltd. | Compositions for drug delivery |
| US6372250B1 (en) | 2000-04-25 | 2002-04-16 | The Regents Of The University Of California | Non-invasive gene targeting to the brain |
| US6846813B2 (en) | 2000-06-30 | 2005-01-25 | Pharmacia & Upjohn Company | Compounds to treat alzheimer's disease |
| PE20020276A1 (es) | 2000-06-30 | 2002-04-06 | Elan Pharm Inc | COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER |
| MXPA02012560A (es) | 2000-06-30 | 2003-05-14 | Elan Pharm Inc | Compuestos para tratar la enfermedad de alzheimer. |
| EP1404718A2 (en) | 2000-12-28 | 2004-04-07 | Oklahoma Medical Research Foundation | Inhibitors of memapsin 2 and use thereof |
| US20040121947A1 (en) | 2000-12-28 | 2004-06-24 | Oklahoma Medical Research Foundation | Compounds which inhibit beta-secretase activity and methods of use thereof |
| WO2002064558A2 (en) | 2001-02-14 | 2002-08-22 | Sankyo Company, Limited | Oxazole derivatives, their preparation and their use as cytokine inhibitors |
| US20060234944A1 (en) | 2001-10-23 | 2006-10-19 | Oklahoma Medical Reseach Foundation | Beta-secretase inhibitors and methods of use |
| CA2464736A1 (en) | 2001-10-23 | 2003-05-15 | Oklahoma Medical Research Foundation | Beta-secretase inhibitors and methods of use |
| EP1453789A2 (en) | 2001-11-08 | 2004-09-08 | Elan Pharmaceuticals, Inc. | N,n'-substituted-1,3-diamino-2-hydroxypropane derivatives |
| BR0214736A (pt) | 2001-12-06 | 2004-11-23 | Elan Pharm Inc | Composto e seus sais farmaceuticamente aceitáveis, composição farmacêutica e método de tratar seres humanos ou animais que sofrem de doenças ou condições |
| MXPA04008317A (es) | 2002-02-27 | 2005-06-08 | Upjohn Co | Hidroxietilaminas sustituidas. |
| AU2003220115A1 (en) | 2002-05-20 | 2003-12-12 | Board Of Regents, The University Of Texas System | Methods and compositions for delivering enzymes and nucleic acid molecules to brain, bone, and other tissues |
| JP2005538162A (ja) | 2002-09-06 | 2005-12-15 | イーラン ファーマスーティカルズ、インコーポレイテッド | １，３−ジアミノ−２−ヒドロキシプロパンプロドラッグ誘導体 |
| CA2505098A1 (en) | 2002-11-12 | 2004-05-27 | Merck & Co., Inc. | Phenylcarboxamide beta-secretase inhibitors for the treatment of alzheimer's disease |
| US20040102369A1 (en) | 2002-11-27 | 2004-05-27 | The Regents Of The University Of California | Transport of basic fibroblast growth factor across the blood brain barrier |
| US7388079B2 (en) | 2002-11-27 | 2008-06-17 | The Regents Of The University Of California | Delivery of pharmaceutical agents via the human insulin receptor |
| GB0228410D0 (en) | 2002-12-05 | 2003-01-08 | Glaxo Group Ltd | Novel Compounds |
| GB0305918D0 (en) | 2003-03-14 | 2003-04-23 | Glaxo Group Ltd | Novel compounds |
| DE602004019793D1 (de) | 2003-08-08 | 2009-04-16 | Schering Corp | Cyclische amine mit benzamidsubstituent als bace-1-inhibitoren |
| KR100793095B1 (ko) | 2003-10-01 | 2008-01-10 | 주식회사 프로메디텍 | Ｂａｃｅ 저해효능을 가진 신규한 술폰 아미드 유도체 |
| AU2004311749A1 (en) | 2003-12-19 | 2005-07-21 | Merck & Co., Inc. | Phenylamide and pyridylamide beta-secretase inhibitors for the treatment of Alzheimer's disease |
| US7585885B2 (en) | 2004-04-22 | 2009-09-08 | Eli Lilly And Company | Pyrrolidine derivatives useful as BACE inhibitors |
| EP1740575A2 (en) | 2004-04-22 | 2007-01-10 | Eli Lilly And Company | Pyrrolidine derivatives useful as bace inhibitors |
| CN1968924B (zh) | 2004-06-15 | 2011-08-03 | 默沙东公司 | 作为β-分泌酶抑制剂用于治疗阿尔茨海默氏病的吡咯烷-3-基化合物 |
| US8436006B2 (en) | 2004-08-06 | 2013-05-07 | Jansssen Pharmaceutica N.V. | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) |
| CA2580238A1 (en) * | 2004-09-17 | 2006-03-30 | Comentis, Inc. | Bicyclic compounds which inhibit beta-secretase activity and methods of use thereof |
| US7659289B2 (en) | 2004-09-17 | 2010-02-09 | Comentis, Inc. | Hydroxyethylene-based β-secretase inhibitors and use thereof |
| CN100475786C (zh) * | 2005-02-18 | 2009-04-08 | 中国科学院上海药物研究所 | 一类4-羟基戊酰胺类化合物及其制备方法和用途 |
| US7745470B2 (en) | 2005-03-10 | 2010-06-29 | Bristol-Myers Squibb Company | Isophthalates as beta-secretase inhibitors |
| JP2008535863A (ja) | 2005-04-08 | 2008-09-04 | コメンティス，インコーポレーテッド | β−セクレターゼ活性を阻害する化合物およびその使用方法 |
| MY144968A (en) | 2005-04-11 | 2011-11-30 | Xenon Pharmaceuticals Inc | Spiro-oxindole compounds and their uses as therapeutic agents |
| AR054044A1 (es) | 2005-05-23 | 2007-05-30 | Astrazeneca Ab | Derivados de cromano y tetrahidronaftaleno como moduladores del receptor 5 - ht6; intermediarios en su preparacion; composiciones farmaceuticas que los contienen y su empelo en la fabricacion de medicamentos para el tratamiento de enfermedades del snc y de la obesidad. |
| AR054363A1 (es) | 2005-05-23 | 2007-06-20 | Astrazeneca Ab | Compuestos que exhiben actividad moduladora en el receptor 5-hidroxi-triptamina 6 |
| GB0513886D0 (en) | 2005-07-06 | 2005-08-10 | Glaxo Group Ltd | Novel compounds |
| US7476764B2 (en) | 2005-08-04 | 2009-01-13 | Bristol-Myers Squibb Company | Phenylcarboxyamides as beta-secretase inhibitors |
| US7790745B2 (en) | 2005-10-21 | 2010-09-07 | Bristol-Myers Squibb Company | Tetrahydroisoquinoline LXR Modulators |
| TW200804290A (en) | 2005-11-15 | 2008-01-16 | Astrazeneca Ab | Compounds and uses thereof |
| US8143405B2 (en) | 2006-09-21 | 2012-03-27 | Merck, Sharp & Dohme Corp | Piperidine and pyrrolidine beta-secretase inhibitors for the treatment of alzheimer's disease |
| WO2009015369A2 (en) | 2007-07-26 | 2009-01-29 | Comentis, Inc. | Compounds which inhibit beta-secretase activity and methods of use thereof |
| EP2205596A1 (en) | 2007-09-24 | 2010-07-14 | Comentis, Inc. | (3-hydroxy-4-amino-butan-2-yl) -3- (2-thiazol-2-yl-pyrrolidine-1-carbonyl) benzamide derivatives and related compounds as beta-secretase inhibitors for treating |
| US8791135B2 (en) | 2008-07-01 | 2014-07-29 | Purdue Research Foundation | Nonpeptide HIV-1 protease inhibitors |
| EP2349244A4 (en) | 2008-10-10 | 2012-09-19 | Comentis Inc | PYRROLIDINE COMPOUNDS THAT PREVENT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF |
| JP2012505241A (ja) | 2008-10-10 | 2012-03-01 | パーデュー・リサーチ・ファウンデーション | アルツハイマー病の治療用組成物 |
| CA2744425A1 (en) | 2008-11-20 | 2010-05-27 | Purdue Research Foundation | Quinazoline inhibitors of bace 1 and methods of using |
| US8859590B2 (en) | 2008-12-05 | 2014-10-14 | Purdue Research Foundation | Inhibitors of BACE1 and methods for treating Alzheimer's disease |
| WO2010110817A1 (en) | 2009-03-25 | 2010-09-30 | Comentis, Inc. | Pyrrolidine compounds which inhibit beta-secretase activity and methods of use thereof |
| EP2486006A4 (en) | 2009-10-05 | 2013-05-01 | Comentis Inc | SULFONAMIDO PYRROLIDINE COMPOUNDS THAT INHIBIT BETA SECRETASE ACTIVITY AND METHODS OF USE THEREOF |
-
2008
- 2008-09-24 EP EP08834393A patent/EP2205596A1/en not_active Withdrawn
- 2008-09-24 KR KR1020107006815A patent/KR20100059919A/ko not_active Withdrawn
- 2008-09-24 JP JP2010526066A patent/JP5055432B2/ja not_active Expired - Fee Related
- 2008-09-24 CN CN2008801172385A patent/CN101868457B/zh not_active Expired - Fee Related
- 2008-09-24 WO PCT/US2008/077537 patent/WO2009042694A1/en not_active Ceased
- 2008-09-24 MX MX2010002938A patent/MX2010002938A/es active IP Right Grant
- 2008-09-24 US US12/677,748 patent/US8299267B2/en not_active Expired - Fee Related
- 2008-09-24 CA CA2699787A patent/CA2699787A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP5055432B2 (ja) | 2012-10-24 |
| CN101868457B (zh) | 2013-02-13 |
| US20100286170A1 (en) | 2010-11-11 |
| WO2009042694A1 (en) | 2009-04-02 |
| US8299267B2 (en) | 2012-10-30 |
| KR20100059919A (ko) | 2010-06-04 |
| JP2010540462A (ja) | 2010-12-24 |
| EP2205596A1 (en) | 2010-07-14 |
| CA2699787A1 (en) | 2009-04-02 |
| CN101868457A (zh) | 2010-10-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2010002938A (es) | Derivados de (3-hidroxi-4-amino-butan-2-il)-3-(2-tiazol-2-il-pirro lidin-1-carbonil)benzamida y compuestos relacionados como inhibidores de beta-secretasa para tratar enfermedad de alzheimer. | |
| UA102251C2 (ru) | Производные аминодигидротиазина как ингибиторы васе для лечения болезни альцгеймера | |
| NO20083207L (no) | Inhibitorer av IAP | |
| PT1902037E (pt) | 2,4-diamino-pirimidinas como inibidores de aurora | |
| TW200728305A (en) | Spiropiperidine beta-sectetase inhibitors for the treatment of alzheimer's disease | |
| PH12013500745A1 (en) | Azaadamantane derivatives and methods of use | |
| EA200900152A1 (ru) | Ингибиторы пирролотриазинкиназы | |
| NO20082136L (no) | 1,5-substituerte indol-2-yl-amidderivater | |
| MX2007011023A (es) | 2-(4-oxo-4h-quinazolin-3-il) acetamidas y su uso como antagonistas de vasopresin v3. | |
| DK2026803T3 (da) | Sammensætninger af R(+) og S(-) pramipexol og fremgangsmåder til anvendelse heraf | |
| EA200801428A1 (ru) | Производные пиридиазинона для лечения опухолей | |
| EA201170344A1 (ru) | Азаиндольные ингибиторы iap | |
| NO20076145L (no) | Ureadeviater, fremgangsmater for deres fremstilling og anvendelse derav | |
| GEP20135959B (en) | Aryl piperazine and their usage as alpha2c antagonists | |
| MX2010007543A (es) | Inhibidores de iap. | |
| MX2010000956A (es) | Derivados de isoftalamida que inhiben actividad de beta-secretasa. | |
| IL183636A0 (en) | Quinoline derivative, use and production thereof, and drug containing the same | |
| IL176111A0 (en) | 2-(1h-indolylsulfanyl)-benzyl amine derivatives as ssri | |
| MX2009012525A (es) | Pirazol-pirrolidinas como inhibidores de gamma secretasa. | |
| TW200745066A (en) | Novel PTP1B inhibitors | |
| DE602004006118D1 (de) | 2,3,4,5-TETRAHYDROBENZOiFöi1,4öOXAZEPIN-5-CARBONSÄUREAMID DERIVATE ALS GAMMA-SECRETASE INHIBITOREN ZUR BEHANDLUNG VON ALZHEIMER | |
| WO2006034296A3 (en) | Amino-containing compounds which inhibit memapsin 2 beta-secretase activity and methods of use thereof | |
| DE602006010738D1 (de) | Pyrroloä2,3-cüpyridinderivate | |
| WO2006055434A3 (en) | Macrocyclic tertiary amine beta-secretase inhibitors for the treatment of alzheimer's disease | |
| ZA200704913B (en) | 3-[2-(3-acylamino-2-oxo-2H-pyridin-1-YL)-acetylamino]-4-oxo-pentanoic acid derivatives and their use as caspase inhibitors |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |