IL91501A - Generation of a variegated library of mutant potential binding proteins and screening of said library for proteins with a desired binding activity - Google Patents

Generation of a variegated library of mutant potential binding proteins and screening of said library for proteins with a desired binding activity

Info

Publication number
IL91501A
IL91501A IL91501A IL9150189A IL91501A IL 91501 A IL91501 A IL 91501A IL 91501 A IL91501 A IL 91501A IL 9150189 A IL9150189 A IL 9150189A IL 91501 A IL91501 A IL 91501A
Authority
IL
Israel
Prior art keywords
protein
ipbd
target
residues
potential binding
Prior art date
Application number
IL91501A
Other languages
English (en)
Other versions
IL91501A0 (en
Original Assignee
Dyax Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22905360&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL91501(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Dyax Corp filed Critical Dyax Corp
Priority to IL12094189A priority Critical patent/IL120941A/xx
Priority to IL12094089A priority patent/IL120940A/xx
Priority to IL12093989A priority patent/IL120939A/en
Publication of IL91501A0 publication Critical patent/IL91501A0/xx
Publication of IL91501A publication Critical patent/IL91501A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
IL91501A 1988-09-02 1989-09-01 Generation of a variegated library of mutant potential binding proteins and screening of said library for proteins with a desired binding activity IL91501A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
IL12094189A IL120941A (en) 1988-09-02 1989-09-01 Chimeric binding protein
IL12094089A IL120940A (en) 1988-09-02 1989-09-01 Fusion proteins displayable on the surface of filamentous phage and a recombinant, filamentous phage bearing the same
IL12093989A IL120939A (en) 1988-09-02 1989-09-01 Method for obtaining nucleic acid encoding a proteinaceous binding domain

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US24016088A 1988-09-02 1988-09-02

Publications (2)

Publication Number Publication Date
IL91501A0 IL91501A0 (en) 1990-04-29
IL91501A true IL91501A (en) 1998-03-10

Family

ID=22905360

Family Applications (1)

Application Number Title Priority Date Filing Date
IL91501A IL91501A (en) 1988-09-02 1989-09-01 Generation of a variegated library of mutant potential binding proteins and screening of said library for proteins with a desired binding activity

Country Status (8)

Country Link
EP (6) EP0768377A1 (de)
JP (1) JP3771253B2 (de)
AT (1) ATE151110T1 (de)
AU (1) AU4308689A (de)
CA (1) CA1340288C (de)
DE (2) DE68927933T2 (de)
IL (1) IL91501A (de)
WO (1) WO1990002809A1 (de)

Families Citing this family (1011)

* Cited by examiner, † Cited by third party
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WO1990002809A1 (en) 1990-03-22
EP1026240A3 (de) 2004-04-07
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DE68927933D1 (de) 1997-05-07
EP0436597A4 (en) 1992-05-20
EP0768377A1 (de) 1997-04-16
EP0436597B1 (de) 1997-04-02
DE768377T1 (de) 1998-01-02
IL91501A0 (en) 1990-04-29
EP0436597A1 (de) 1991-07-17
EP1541682A2 (de) 2005-06-15
JP3771253B2 (ja) 2006-04-26
JPH04502700A (ja) 1992-05-21
EP1892296A1 (de) 2008-02-27
EP1997891A1 (de) 2008-12-03
ATE151110T1 (de) 1997-04-15
AU4308689A (en) 1990-04-02
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CA1340288C (en) 1998-12-29

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