MA47812A - Composés interagissant avec le glycane et méthodes d'utilisation - Google Patents
Composés interagissant avec le glycane et méthodes d'utilisationInfo
- Publication number
- MA47812A MA47812A MA047812A MA47812A MA47812A MA 47812 A MA47812 A MA 47812A MA 047812 A MA047812 A MA 047812A MA 47812 A MA47812 A MA 47812A MA 47812 A MA47812 A MA 47812A
- Authority
- MA
- Morocco
- Prior art keywords
- glycan
- methods
- compounds interacting
- interacting
- compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 150000004676 glycans Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Zoology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762466766P | 2017-03-03 | 2017-03-03 | |
US201762480126P | 2017-03-31 | 2017-03-31 | |
US201762486826P | 2017-04-18 | 2017-04-18 | |
US201762563718P | 2017-09-27 | 2017-09-27 | |
US201762577830P | 2017-10-27 | 2017-10-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA47812A true MA47812A (fr) | 2021-04-14 |
Family
ID=63371128
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA047812A MA47812A (fr) | 2017-03-03 | 2018-03-02 | Composés interagissant avec le glycane et méthodes d'utilisation |
Country Status (14)
Country | Link |
---|---|
US (3) | US11253609B2 (fr) |
EP (1) | EP3589319A4 (fr) |
JP (3) | JP2020510671A (fr) |
KR (2) | KR20240044544A (fr) |
CN (1) | CN110913903B (fr) |
AU (1) | AU2018226824A1 (fr) |
BR (1) | BR112019018043A2 (fr) |
CA (1) | CA3054939A1 (fr) |
IL (1) | IL268966A (fr) |
MA (1) | MA47812A (fr) |
MX (2) | MX2019010202A (fr) |
SG (1) | SG11201907889YA (fr) |
WO (1) | WO2018160909A1 (fr) |
ZA (1) | ZA201905677B (fr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
US9725710B2 (en) | 2014-01-08 | 2017-08-08 | Flodesign Sonics, Inc. | Acoustophoresis device with dual acoustophoretic chamber |
WO2016077526A1 (fr) | 2014-11-12 | 2016-05-19 | Siamab Therapeutics, Inc. | Composés interagissant avec le glycane et procédés d'utilisation |
US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
CN116217729A (zh) * | 2015-11-12 | 2023-06-06 | 思进公司 | 聚糖相互作用化合物及使用方法 |
US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
US11401330B2 (en) | 2016-11-17 | 2022-08-02 | Seagen Inc. | Glycan-interacting compounds and methods of use |
JP2020510671A (ja) | 2017-03-03 | 2020-04-09 | シアトル ジェネティックス, インコーポレイテッド | グリカン相互作用化合物および使用の方法 |
CN114900773A (zh) | 2017-12-14 | 2022-08-12 | 弗洛设计声能学公司 | 声泳系统及其操作方法、控制声换能器及声学系统的方法 |
EP4065605A4 (fr) * | 2019-11-26 | 2023-07-12 | Ramot at Tel-Aviv University Ltd. | Anticorps dirigés contre des antigènes glucidiques |
CN115103858A (zh) * | 2020-03-25 | 2022-09-23 | 江苏恒瑞医药股份有限公司 | 一种抗体药物偶联物的制备方法 |
EP4251653A4 (fr) * | 2020-11-24 | 2024-06-19 | Univ Ramot | Anticorps humanisés et fragments de ceux-ci se liant à des antigènes glucidiques et leurs utilisations |
CN112461807B (zh) * | 2020-11-26 | 2021-11-19 | 山西大学 | 碳量子点在靶向细胞核仁免洗成像中的应用 |
Family Cites Families (239)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
US4444887A (en) | 1979-12-10 | 1984-04-24 | Sloan-Kettering Institute | Process for making human antibody producing B-lymphocytes |
US6872868B1 (en) | 1981-06-12 | 2005-03-29 | Ohio University | Transgenic mammals |
US4714681A (en) | 1981-07-01 | 1987-12-22 | The Board Of Reagents, The University Of Texas System Cancer Center | Quadroma cells and trioma cells and methods for the production of same |
US4474893A (en) | 1981-07-01 | 1984-10-02 | The University of Texas System Cancer Center | Recombinant monoclonal antibodies |
US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
US4640835A (en) | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
US4716111A (en) | 1982-08-11 | 1987-12-29 | Trustees Of Boston University | Process for producing human antibodies |
GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
US4496689A (en) | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
EP0206448B1 (fr) | 1985-06-19 | 1990-11-14 | Ajinomoto Co., Inc. | Hémoglobine liée à un poly(oxyde d'alkylène) |
US4965198A (en) | 1985-12-24 | 1990-10-23 | Konica Corporation | Monoclonal antibody and method of manufacturing hybridoma producing the same |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
IN164232B (fr) | 1986-04-11 | 1989-02-04 | Hoechst India | |
US4695198A (en) | 1986-05-23 | 1987-09-22 | Chevron Research Company | Lip-type sealing system for a removable bottom founded structure |
US4791192A (en) | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
US5059680A (en) | 1986-11-24 | 1991-10-22 | Centocor, Inc. | Method of isolating ca 125 antigen |
US5258498A (en) | 1987-05-21 | 1993-11-02 | Creative Biomolecules, Inc. | Polypeptide linkers for production of biosynthetic proteins |
US5091513A (en) | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
CA1340927C (fr) | 1987-10-09 | 2000-03-14 | Peter S. Linsley | Procede d'hypersensibilisation d'essais a des ligands specifiques |
IT1212041B (it) | 1987-11-02 | 1989-11-08 | Fidia Farmaceutici | Gangliosidi esteri interni come agenti terapeutici capaci di eliminare il dolore nelle neuropatie periferiche |
JPH02486A (ja) | 1987-11-13 | 1990-01-05 | Mect Corp | 遊離n−アセチルノイラミン酸を認識するモノクローナル抗体 |
US4978745A (en) | 1987-11-23 | 1990-12-18 | Centocor, Inc. | Immunoreactive heterochain antibodies |
US4975369A (en) | 1988-04-21 | 1990-12-04 | Eli Lilly And Company | Recombinant and chimeric KS1/4 antibodies directed against a human adenocarcinoma antigen |
US4925648A (en) | 1988-07-29 | 1990-05-15 | Immunomedics, Inc. | Detection and treatment of infectious and inflammatory lesions |
US5601819A (en) | 1988-08-11 | 1997-02-11 | The General Hospital Corporation | Bispecific antibodies for selective immune regulation and for selective immune cell binding |
DE68927933T2 (de) | 1988-09-02 | 1997-08-14 | Dyax Corp | Herstellung und auswahl von rekombinantproteinen mit verschiedenen bindestellen |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
EP0479909B1 (fr) | 1989-06-29 | 1996-10-30 | Medarex, Inc. | Reactifs bispecifiques pour le traitement du sida |
US5413923A (en) | 1989-07-25 | 1995-05-09 | Cell Genesys, Inc. | Homologous recombination for universal donor cells and chimeric mammalian hosts |
US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
WO1991010737A1 (fr) | 1990-01-11 | 1991-07-25 | Molecular Affinities Corporation | Production d'anticorps utilisant des librairies de genes |
US5780225A (en) | 1990-01-12 | 1998-07-14 | Stratagene | Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules |
SG48759A1 (en) | 1990-01-12 | 2002-07-23 | Abgenix Inc | Generation of xenogenic antibodies |
US6075181A (en) | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
GB9012995D0 (en) | 1990-06-11 | 1990-08-01 | Celltech Ltd | Multivalent antigen-binding proteins |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
US6300129B1 (en) | 1990-08-29 | 2001-10-09 | Genpharm International | Transgenic non-human animals for producing heterologous antibodies |
US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5698426A (en) | 1990-09-28 | 1997-12-16 | Ixsys, Incorporated | Surface expression libraries of heteromeric receptors |
AU667460B2 (en) | 1990-10-05 | 1996-03-28 | Medarex, Inc. | Targeted immunostimulation with bispecific reagents |
AU8727291A (en) | 1990-10-29 | 1992-06-11 | Cetus Oncology Corporation | Bispecific antibodies, method of production, and uses thereof |
ATE164395T1 (de) | 1990-12-03 | 1998-04-15 | Genentech Inc | Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften |
WO1992018619A1 (fr) | 1991-04-10 | 1992-10-29 | The Scripps Research Institute | Banques de recepteurs heterodimeres utilisant des phagemides |
EP0511011B1 (fr) | 1991-04-26 | 1996-10-23 | Surface Active Limited | Anticorps nouveaux et méthodes pour leur utilisation |
DE69233482T2 (de) | 1991-05-17 | 2006-01-12 | Merck & Co., Inc. | Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen |
ES2136092T3 (es) | 1991-09-23 | 1999-11-16 | Medical Res Council | Procedimientos para la produccion de anticuerpos humanizados. |
EP0617706B1 (fr) | 1991-11-25 | 2001-10-17 | Enzon, Inc. | Proteines multivalentes de fixation aux antigenes |
US5932448A (en) | 1991-11-29 | 1999-08-03 | Protein Design Labs., Inc. | Bispecific antibody heterodimers |
PT1696031E (pt) | 1991-12-02 | 2010-06-25 | Medical Res Council | Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos |
EP1306095A3 (fr) | 1992-03-05 | 2003-06-25 | Board Of Regents, The University Of Texas System | Méthodes et compositions pour cibler les vaisceaux des tumeurs solides |
US5733743A (en) | 1992-03-24 | 1998-03-31 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
CA2076465C (fr) | 1992-03-25 | 2002-11-26 | Ravi V. J. Chari | Conjugues agents de liaison cellulaire d'analogues et de derives de cc-1065 |
US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
US5951983A (en) | 1993-03-05 | 1999-09-14 | Universite Catholique De Louvain | Methods of inhibiting T cell mediated immune responses with humanized LO-CD2A-specific antibodies |
US20030108548A1 (en) | 1993-06-01 | 2003-06-12 | Bluestone Jeffrey A. | Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies |
JPH09506262A (ja) | 1993-12-08 | 1997-06-24 | ジェンザイム・コーポレイション | 特異的抗体の製造方法 |
DE69534347T2 (de) | 1994-01-31 | 2006-05-24 | Trustees Of Boston University, Boston | Bibliotheken aus Polyklonalen Antikörpern |
US5516637A (en) | 1994-06-10 | 1996-05-14 | Dade International Inc. | Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage |
US5786464C1 (en) | 1994-09-19 | 2012-04-24 | Gen Hospital Corp | Overexpression of mammalian and viral proteins |
US5919652A (en) | 1994-11-09 | 1999-07-06 | The Regents Of The University Of California | Nucleic acid molecules comprising the prostate specific antigen (PSA) promoter and uses thereof |
US5710038A (en) | 1994-11-25 | 1998-01-20 | Universite De Montreal | Primary cultures of normal and tumoral human ovarian epithelium |
US5811510A (en) | 1995-04-14 | 1998-09-22 | General Hospital Corporation | Biodegradable polyacetal polymers and methods for their formation and use |
KR100654645B1 (ko) | 1995-04-27 | 2007-04-04 | 아브게닉스, 인크. | 면역화된 제노마우스 유래의 인간 항체 |
CA2219486A1 (fr) | 1995-04-28 | 1996-10-31 | Abgenix, Inc. | Anticorps humains derives de xeno-souris immunisees |
US5733920A (en) | 1995-10-31 | 1998-03-31 | Mitotix, Inc. | Inhibitors of cyclin dependent kinases |
JP2978435B2 (ja) | 1996-01-24 | 1999-11-15 | チッソ株式会社 | アクリロキシプロピルシランの製造方法 |
US5849733A (en) | 1996-05-10 | 1998-12-15 | Bristol-Myers Squibb Co. | 2-thio or 2-oxo flavopiridol analogs |
EP0912890A4 (fr) | 1996-07-03 | 2002-01-02 | Millennium Pharm Inc | Depistage du cancer par analyse de recherche d'antigenes specifiques du cancer presentant des oligosaccharides lies qui sont au moins triantennaires |
US6114148C1 (en) | 1996-09-20 | 2012-05-01 | Gen Hospital Corp | High level expression of proteins |
US5916771A (en) | 1996-10-11 | 1999-06-29 | Abgenix, Inc. | Production of a multimeric protein by cell fusion method |
US6348584B1 (en) | 1996-10-17 | 2002-02-19 | John Edward Hodgson | Fibronectin binding protein compounds |
KR20080059467A (ko) | 1996-12-03 | 2008-06-27 | 아브게닉스, 인크. | 복수의 vh 및 vk 부위를 함유하는 사람 면역글로불린유전자좌를 갖는 형질전환된 포유류 및 이로부터 생성된항체 |
KR100663319B1 (ko) | 1997-04-14 | 2007-01-02 | 마이크로메트 에이지 | 인간 17-1에이항원에 대해 특이성을 갖는 인간항체 및 그용도 |
US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
ES2301198T3 (es) | 1997-06-12 | 2008-06-16 | Novartis International Pharmaceutical Ltd. | Polipeptidos artificiales de anticuerpos. |
WO1999014353A2 (fr) | 1997-09-19 | 1999-03-25 | Dana-Farber Cancer Institute, Inc. | Regulation a mediation intracorps de reactions immunitaires. |
CA2311729A1 (fr) | 1998-01-23 | 1999-07-29 | Imclone Systems Incorporated | Populations purifiees de cellules souches |
WO2000023573A2 (fr) | 1998-10-20 | 2000-04-27 | City Of Hope | Cellules modifiees specifiques a la molecule cd20 et utilisation de ces dernieres pour l'immunotherapie cellulaires des malignites cd20?+¿ |
US20030170249A1 (en) | 1999-02-19 | 2003-09-11 | Hakomori Sen-Itiroh | Vaccines directed to cancer-associated carbohydrate antigens |
US20020012660A1 (en) | 1999-03-04 | 2002-01-31 | Alan Colman | Method of preparing a somatic cells for nuclear transfer |
GB2344886B (en) | 1999-03-10 | 2000-11-01 | Medical Res Council | Selection of intracellular immunoglobulins |
EP1196031A1 (fr) | 1999-06-16 | 2002-04-17 | Biocrystal Limited | Formulations de vaccins et procedes d'immunisation d'un sujet contre les lymphocytes b specifiques d'un antigene excrete |
IL150018A0 (en) | 1999-12-06 | 2002-12-01 | Agensys Inc | Novel serpentine transmembrane antigens expressed in human cancers and uses thereof |
US20030008813A1 (en) | 1999-12-17 | 2003-01-09 | Felgner Philip L. | Intracellular protein delivery compositions and methods of use |
WO2001043778A1 (fr) | 1999-12-17 | 2001-06-21 | Gene Therapy Systems, Inc. | Utilisation de lipides cationiques pour administration de proteines intracellulaires |
US7279294B2 (en) | 2000-04-03 | 2007-10-09 | The United States Of America As Represented By The Secretary, Dept. Of Health And Human Services, Nih | Tumor markers in ovarian cancer |
IT1317922B1 (it) | 2000-10-24 | 2003-07-15 | S I S S A Scuola Internaz Supe | Metodo per identificare in vivo epitopi intracellulari. |
EP1334188B1 (fr) | 2000-11-07 | 2006-08-30 | City of Hope | Cellules immunitaires specifiques a cd19 redirigees |
AU2002338446A1 (en) | 2001-01-23 | 2002-11-05 | University Of Rochester Medical Center | Methods of producing or identifying intrabodies in eukaryotic cells |
EP1389071A2 (fr) | 2001-02-26 | 2004-02-18 | Sabina Glozman | Systemes, dispositifs et procedes d'administration intracorporelle ciblee et de rechargement d'agents therapeutiques |
GB0108165D0 (en) | 2001-03-31 | 2001-05-23 | Univ Manchester | Intracellular analysis |
US20090257994A1 (en) | 2001-04-30 | 2009-10-15 | City Of Hope | Chimeric immunoreceptor useful in treating human cancers |
CA2445746C (fr) | 2001-04-30 | 2012-09-18 | City Of Hope | Immunorecepteur chimerique utilise dans le traitement des cancers humains |
US7514537B2 (en) | 2001-04-30 | 2009-04-07 | City Of Hope | Chimeric immunoreceptor useful in treating human gliomas |
ES2530872T3 (es) | 2001-04-30 | 2015-03-06 | Rbc Biotechnology Inc | Organos y células modificados para xenotrasplante |
KR100486784B1 (ko) | 2001-05-22 | 2005-04-29 | 김하형 | 솔비나무로 부터 추출된 렉틴 단백질, 그의 제조방법 및용도 |
WO2002094199A2 (fr) | 2001-05-24 | 2002-11-28 | Immucom Inc. | Procede d'augmentation des niveaux d'anticorps anti-neugc dans le sang |
US6814734B2 (en) | 2001-06-18 | 2004-11-09 | Sdgi Holdings, Inc, | Surgical instrumentation and method for forming a passage in bone having an enlarged cross-sectional portion |
JP4355571B2 (ja) | 2001-07-19 | 2009-11-04 | ウニベルジテート チューリッヒ | ヒト可変ドメインの改変 |
JP2004538324A (ja) | 2001-08-03 | 2004-12-24 | メディカル リサーチ カウンシル | 細胞内抗体 |
US20050042714A1 (en) | 2001-08-17 | 2005-02-24 | Michael Pawlita | Glycoconjugates of sialic acid derivates, methods for their production and use thereof |
EP1442063A2 (fr) | 2001-11-09 | 2004-08-04 | Hexal Biotech Forschungsgmbh | Anticorps a anti-n-glycolyl-acide neuraminique et leur utilisation pour determiner la presence de glycoproteines |
CA2471363C (fr) | 2001-12-21 | 2014-02-11 | Human Genome Sciences, Inc. | Proteines hybrides d'albumine |
DK1470124T3 (da) | 2002-01-22 | 2006-04-18 | Warner Lambert Co | 2-(Pyridin-2-yl amino)-pyrido[2,3]pyrimidin-7-oner |
GB0201611D0 (en) | 2002-01-24 | 2002-03-13 | Grosveld Frank | Transgenic animal |
GB0226723D0 (en) | 2002-11-15 | 2002-12-24 | Medical Res Council | Antibodies for in vitro use |
WO2003077945A1 (fr) | 2002-03-14 | 2003-09-25 | Medical Research Council | Anticorps intracellulaires |
GB0226727D0 (en) | 2002-11-15 | 2002-12-24 | Medical Res Council | Intrabodies |
WO2003086276A2 (fr) | 2002-04-05 | 2003-10-23 | Selective Genetics, Inc. | Compositions et procedes pour administration genique a specificite de porte et traitement des infections |
DK2332989T3 (en) | 2002-05-22 | 2015-05-11 | Esbatech Alcon Biomed Res Unit | IMMUNGLOBULIN FRAMEWORKS PROVIDING IMPROVED STABILITY IN THE INTRACELLULAR ENVIRONMENT AND PROCEDURES FOR IDENTIFICATION THEREOF |
US7119200B2 (en) | 2002-09-04 | 2006-10-10 | Schering Corporation | Pyrazolopyrimidines as cyclin dependent kinase inhibitors |
GB0226729D0 (en) | 2002-11-15 | 2002-12-24 | Medical Res Council | Intracellular antibodies |
JP2006521088A (ja) | 2002-11-15 | 2006-09-21 | メディカル リサーチ カウンシル | 抗活性化ras抗体 |
GB0226731D0 (en) | 2002-11-15 | 2002-12-24 | Medical Res Council | Method for generating immunoglobulin genes |
ITRM20020588A1 (it) | 2002-11-21 | 2004-05-22 | Lay Line Genomics Spa | Metodo per isolare anticorpi intracellulari neutralizzanti di interazioni proteiche. |
EP1482309A1 (fr) | 2003-05-07 | 2004-12-01 | Institut Curie | Moyens pour la détection de la conformation de protéines et leurs applications |
CN1835951B (zh) | 2003-07-11 | 2010-06-02 | 沃尼尔·朗伯有限责任公司 | 选择性cdk4抑制剂的羟乙基磺酸盐 |
WO2005010485A2 (fr) | 2003-07-15 | 2005-02-03 | The Regents Of The University Of California | Procedes pour detecter et analyser l'acide n-glycolylneuraminique (neu5gc) dans des matieres biologiques |
ITMI20031909A1 (it) | 2003-10-03 | 2005-04-04 | Keryos Spa | Linee cellulari di mammifero modificate per la produzione di glicoproteine ricombinanti. |
WO2005063817A2 (fr) | 2003-12-22 | 2005-07-14 | Amgen Inc. | Procédés d'identification d'anticorps fonctionnels |
JP2007527539A (ja) | 2004-03-05 | 2007-09-27 | ザ スクリプス リサーチ インスティテュート | ハイスループットグリカンマイクロアレイ |
EP1740616B1 (fr) | 2004-04-30 | 2011-12-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Anticorps anti-tfr |
KR100620554B1 (ko) * | 2004-06-05 | 2006-09-06 | 한국생명공학연구원 | Tag-72에 대한 인간화 항체 |
WO2006002382A2 (fr) | 2004-06-24 | 2006-01-05 | The Scripps Research Institute | Reseaux de liants clivables |
US7638467B2 (en) | 2004-08-03 | 2009-12-29 | Intevep, S.A. | Reversible gelling system and method using same during well treatments |
CA2585717A1 (fr) | 2004-10-27 | 2006-05-04 | Medimmune Inc. | Modulation d'une specificite d'anticorps par adaptation sur mesure de son affinite a un antigene apparente |
WO2006068758A2 (fr) | 2004-11-19 | 2006-06-29 | The Scripps Research Institute | Detection, prevention et traitement du cancer du sein |
US7585503B2 (en) | 2005-03-31 | 2009-09-08 | Nahid Razi | Method for detecting multi-drug resistance |
US8008443B2 (en) | 2005-04-26 | 2011-08-30 | Medimmune, Llc | Modulation of antibody effector function by hinge domain engineering |
US20090041783A1 (en) | 2005-04-28 | 2009-02-12 | Mochida Pharmaceutical Co., Ltd. | Anti-platelet membrane glycoprotein vi monoclonal antibody |
US20080166805A1 (en) | 2005-06-08 | 2008-07-10 | The Regents Of The University Of California | Culturing human cells and tissues in an N-glycolylneuraminic acid-free environment |
CA2620343C (fr) | 2005-08-24 | 2013-01-08 | Immunogen, Inc. | Procede de preparation de conjugues maytansinoides-anticorps |
SG10201602095PA (en) | 2005-12-20 | 2016-05-30 | Sbi Biotech Co Ltd | Anti-Ilt7 Antibody |
WO2007079448A2 (fr) | 2006-01-03 | 2007-07-12 | University Of Georgia Research Foundation, Inc. | Vaccin glucidique à trois composants |
ATE509027T1 (de) | 2006-01-13 | 2011-05-15 | Pasteur Institut | Enzymatische synthese von grossen mengen von mucin glyconjugaten und deren immunogenische anwendungen |
EP2389951A1 (fr) | 2006-03-23 | 2011-11-30 | Novartis AG | Thérapeutique anticorps antigène de cellules anti-tumorales |
CA2646807A1 (fr) | 2006-03-31 | 2007-10-18 | Mochida Pharmaceutical Co., Ltd. | Nouveau marqueur de l'activation plaquettaire et son procede de determination |
US20070265170A1 (en) | 2006-05-15 | 2007-11-15 | Ola Blixt | Detection, prevention and treatment of ovarian cancer |
GB0613209D0 (en) | 2006-07-03 | 2006-08-09 | Ucb Sa | Methods |
JP2010505775A (ja) | 2006-10-04 | 2010-02-25 | クーベンハヴンス・ユニヴェルシテット | Muc1に対する癌特異的な免疫反応の産生及び癌特異的muc1抗体 |
US20100143371A1 (en) | 2006-10-31 | 2010-06-10 | Zhenping Zhu | Intrabodies |
WO2008053486A1 (fr) | 2006-11-02 | 2008-05-08 | Sylvie Luria | Procédés pour dépister des molécules thérapeutiques et utilisation des molécules issues de ces procédés |
WO2009018438A1 (fr) | 2007-07-31 | 2009-02-05 | Cornell Research Foundation, Inc. | Découverte de protéine utilisant un affichage de ribosome intracellulaire |
EP2014302A1 (fr) | 2007-07-12 | 2009-01-14 | Institut Curie | Anticorps spécifique à l'antigène Tn pour le traitement du cancer |
WO2009035494A2 (fr) | 2007-07-30 | 2009-03-19 | The Scripps Research Institute | Méthodes de production d'anticorps anti-glycane, vaccins et méthodes de traitement du cancer ou de maladies infectieuses |
FI20070853A0 (fi) | 2007-11-09 | 2007-11-09 | Glykos Finland Oy | Glykaania sitovat monoklonaaliset vasta-aineet |
CA2705292C (fr) | 2007-11-13 | 2016-06-21 | Teva Biopharmaceuticals Usa, Inc. | Anticorps humanises contre tl1a |
WO2009091826A2 (fr) | 2008-01-14 | 2009-07-23 | The Board Of Regents Of The University Of Texas System | Compositions et procédés associés à un récepteur d'antigène chimérique spécifique du cd19 humain (h-car) |
US20120027813A1 (en) | 2008-02-22 | 2012-02-02 | Novartis Vaccines And Diagnostics Srl | Adjuvanted influenza vaccines for pediatric use |
US8506966B2 (en) | 2008-02-22 | 2013-08-13 | Novartis Ag | Adjuvanted influenza vaccines for pediatric use |
US8298773B2 (en) | 2008-05-02 | 2012-10-30 | Marko Vuskovic | Methods, assays and kits for cancer diagnosis and screening utilizing glycan-binding and glycan epitopes |
WO2009147781A1 (fr) | 2008-06-02 | 2009-12-10 | 国立大学法人東京大学 | Agent antitumoral |
US20120039984A1 (en) | 2008-07-03 | 2012-02-16 | University Of Georgia Research Foundation, Inc. | Glycopeptide and uses thereof |
EP2143735A1 (fr) | 2008-07-10 | 2010-01-13 | Institut Pasteur | Domaines variables d'anticorps de camélidé à chaîne lourde dirigés contre les protéines acides fibrillaires gliales |
US20100009424A1 (en) | 2008-07-14 | 2010-01-14 | Natasha Forde | Sonoporation systems and methods |
FI20095418A0 (fi) | 2009-04-16 | 2009-04-16 | Suomen Punainen Risti Veripalv | Kryptinen subpopulaatio |
KR101353857B1 (ko) | 2008-08-22 | 2014-01-21 | 노파르티스 아게 | Cdk 억제제로서 피롤로피리미딘 화합물 |
CA2736488A1 (fr) | 2008-09-09 | 2010-03-18 | The Regents Of The University Of California | Elimination d'un acide sialique non-humain contaminant par competition metabolique |
US20120045816A1 (en) | 2008-09-09 | 2012-02-23 | Sialix, Inc. | Novel Glycosylated Polypeptides |
JO2885B1 (en) | 2008-12-22 | 2015-03-15 | ايلي ليلي اند كومباني | Protein kinase inhibitors |
US20100178292A1 (en) | 2009-01-12 | 2010-07-15 | The Board Of Trustees Of The Leland Stanford Junior University | Cryptic glycan markers and applications thereof |
US8669085B2 (en) | 2009-02-05 | 2014-03-11 | Ut-Battelle, Llc | Transformation of gram positive bacteria by sonoporation |
KR20120057588A (ko) | 2009-05-28 | 2012-06-05 | 메르사나 테라퓨틱스, 인코포레이티드 | 가변 속도 방출 링커를 포함하는 폴리알 약물 접합체 |
US8399625B1 (en) | 2009-06-25 | 2013-03-19 | ESBATech, an Alcon Biomedical Research Unit, LLC | Acceptor framework for CDR grafting |
CA2766409C (fr) | 2009-07-03 | 2023-04-25 | Avipep Pty Ltd | Immunoconjugues et leurs procedes de production |
EP2275442A1 (fr) | 2009-07-06 | 2011-01-19 | Ludwig-Maximilians-Universität München | Détection et visualisation du cycle cellulaire dans des cellules vivantes |
CN102574915B (zh) | 2009-08-06 | 2014-10-22 | 伊缪纳斯制药株式会社 | 特异性结合Aβ寡聚体的抗体及其用途 |
EP2287202A1 (fr) | 2009-08-07 | 2011-02-23 | Dublin City University | Molécules d'anticorps anti-acide sialique |
AU2010301042B2 (en) | 2009-10-01 | 2014-03-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-vascular endothelial growth factor receptor-2 chimeric antigen receptors and use of same for the treatment of cancer |
CA2781682A1 (fr) | 2009-12-04 | 2011-06-09 | Genentech, Inc. | Anticorps plurispecifiques, analogues d'anticorps, compositions et procedes |
US20110177614A1 (en) | 2010-01-15 | 2011-07-21 | The Regents Of The University Of California | Compositions and methods for detecting cancer |
EP2347769A1 (fr) | 2010-01-20 | 2011-07-27 | Glycotope GmbH | Marqueurs de cellules souches de cancer et utilisations associées |
EP2565268A4 (fr) | 2010-04-28 | 2013-10-09 | Shionogi & Co | Nouvel anticorps muc1 |
WO2011139974A2 (fr) | 2010-05-03 | 2011-11-10 | Abbott Laboratories | Anticorps anti-pai-1 et leurs procédés d'utilisation |
CN103209701B (zh) | 2010-06-11 | 2016-08-03 | 乔治亚大学研究基金公司 | 免疫原性疫苗 |
US9511015B2 (en) | 2010-07-13 | 2016-12-06 | Ultragenyx Pharmaceutical Inc. | Methods and formulations for treating sialic acid deficiencies |
EP2407487A1 (fr) | 2010-07-14 | 2012-01-18 | F-Star Biotechnologische Forschungs - und Entwicklungsges. M.B.H. | Anticorps modulaires multi-spécifiques |
JP6157352B2 (ja) | 2010-10-08 | 2017-07-05 | シティ・オブ・ホープCity of Hope | メディトープ(Meditope)のためのモノクローナル抗体フレームワーク結合インターフェース、メディトープ送達系、およびその使用法 |
AR083797A1 (es) | 2010-11-10 | 2013-03-20 | Novartis Ag | Succinato de dimetil-amida del acido 7-ciclopentil-2-(5-piperazin-1-il-piridin-2-il-amino)-7h-pirrolo-[2,3-d]pirimidin-6-carboxilico, proceso para prepararla, intermediarios de dicha sintesis y proceso de preparacion de los mismos |
DK2649086T3 (en) | 2010-12-09 | 2017-09-18 | Univ Pennsylvania | USING CHEMICAL ANTIGEN RECEPTOR-MODIFIED T-CELLS TO TREAT CANCER |
MX2013006234A (es) | 2011-01-06 | 2013-08-01 | Univ Johns Hopkins | Metodo para la produccion de glicoproteinas recombinantes con semivida en circulacion incrementada en celulas de mamifero. |
JP2014506787A (ja) | 2011-02-01 | 2014-03-20 | エイチアイビーエム リサーチ グループ,インコーポレイテッド | シアル酸産生を増加させて、シアル酸に関連した病状を治療する方法および組成物 |
US20140005069A1 (en) | 2011-03-01 | 2014-01-02 | Glycosensors And Diagnostics, Llc. | Glycoprofiling with multiplexed suspension arrays |
EP2703485B1 (fr) | 2011-03-30 | 2018-12-26 | National University Corporation University Of Toyama | Procédé de sélection de plasmocytes et de plasmoblastes, et procédé de production d'un anticorps spécifique d'un antigène cible |
CN106110332B (zh) | 2011-06-10 | 2018-11-30 | 梅尔莎纳医疗公司 | 蛋白质-聚合物-药物共轭物 |
JP6244301B2 (ja) | 2011-08-18 | 2017-12-06 | アフィニティ バイオサイエンス ピーティーワイ リミテッド | 可溶性ポリペプチド |
WO2013033420A1 (fr) | 2011-08-30 | 2013-03-07 | Whitehead Institute For Biomedical Research | Procédés utilisant des inhibiteurs de bromodomaine pour réguler à la baisse l'expression d'un oncogène transloqué |
EA201490636A1 (ru) | 2011-09-16 | 2014-08-29 | Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания | Сконструированные с помощью рнк t-клетки для лечения злокачественных новообразований |
EP3741773A1 (fr) | 2011-10-10 | 2020-11-25 | City of Hope | Méditopes et anticorps de liaison de méditopes et leurs utilisations |
US10391126B2 (en) | 2011-11-18 | 2019-08-27 | Board Of Regents, The University Of Texas System | CAR+ T cells genetically modified to eliminate expression of T-cell receptor and/or HLA |
SI2794658T1 (sl) | 2011-12-19 | 2017-05-31 | Synimmune Gmbh | Bispecifična molekula protitelesa |
WO2013103800A1 (fr) | 2012-01-06 | 2013-07-11 | Bioalliance C.V. | Anticorps de récepteur d'anti-transferrine et leurs procédés |
WO2013126712A1 (fr) | 2012-02-22 | 2013-08-29 | The Trustees Of The University Of Pennsylvania | Topicompositions et procédés pour produire une population de lymphocytes t tenaces utiles dans le traitement du cancer |
EP2825561A4 (fr) | 2012-03-15 | 2016-03-09 | Permeon Biolog Inc | Compositions pénétrant les cellules pour l'administration d'anticorps intracellulaires et de groupes fonctionnels intracellulaires semblables aux anticorps, et procédés d'utilisation |
WO2013151649A1 (fr) | 2012-04-04 | 2013-10-10 | Sialix Inc | Composés d'interaction avec des glycanes |
EP2885002A4 (fr) | 2012-08-14 | 2016-04-20 | Ibc Pharmaceuticals Inc | Anticorps bispécifiques redirigés contre des cellules t pour le traitement de maladies |
KR101732552B1 (ko) | 2012-08-22 | 2017-05-08 | 재단법인 목암생명과학연구소 | 안정화된 면역글로불린가변도메인 선별방법 및 선별된 도메인의 응용 |
WO2014039513A2 (fr) | 2012-09-04 | 2014-03-13 | The Trustees Of The University Of Pennsylvania | Inhibition de la diacylglycérol kinase pour augmenter le transfert de lymphocyte t adoptif |
WO2014055771A1 (fr) | 2012-10-05 | 2014-04-10 | The Trustees Of The University Of Pennsylvania | Récepteur d'antigène chimérique de récepteur alpha du folate humain |
WO2014093379A1 (fr) | 2012-12-10 | 2014-06-19 | Mersana Therapeutics, Inc. | Composés auristatine et leurs conjugués |
PL2935331T3 (pl) | 2012-12-24 | 2018-07-31 | Abbvie Inc. | Białka wiążące receptor prolaktyny i ich zastosowania |
EP2752487A1 (fr) | 2013-01-03 | 2014-07-09 | Sanofi | Criblage phénotypique intracellulaire |
US20160022829A1 (en) | 2013-03-14 | 2016-01-28 | Mersana Therapeutics, Inc. | Tubulysin compounds and conjugates thereof |
BR112015022978A8 (pt) | 2013-03-15 | 2018-01-23 | Memorial Sloan Kettering Cancer Center | tecnologias de multimerização |
CA2903056A1 (fr) | 2013-03-15 | 2014-09-18 | Merck Patent Gmbh | Anticorps bispecifiques tetravalents |
US9718888B2 (en) | 2013-07-23 | 2017-08-01 | Ohio State Innovation Foundation | Methods and compositions related to single chain antibody fragments that bind to tumor-associated glycoprotein 72 (TAG-72) |
WO2015048748A1 (fr) | 2013-09-30 | 2015-04-02 | Board Of Regents, The University Of Texas System | Peptides spécifiques dirigés contre les cellules myéloïdes suppressives (mdsc), à usage diagnostique et thérapeutique |
US20160264684A1 (en) | 2013-10-10 | 2016-09-15 | Siamab Therapeutics, Inc. | Glycan-interacting compounds and methods of use |
WO2015134488A1 (fr) | 2014-03-04 | 2015-09-11 | Sigma-Aldrich Co. Llc | Cellules résistantes aux virus et utilisations de celles-ci |
GB201406767D0 (en) | 2014-04-15 | 2014-05-28 | Cancer Rec Tech Ltd | Humanized anti-Tn-MUC1 antibodies anf their conjugates |
PT3148579T (pt) * | 2014-05-28 | 2021-03-11 | Ludwig Inst For Cancer Res Ltd | Anticorpos anti-gitr e métodos da sua utilização |
TWI695011B (zh) | 2014-06-18 | 2020-06-01 | 美商梅爾莎納醫療公司 | 抗her2表位之單株抗體及其使用之方法 |
CN106714822A (zh) * | 2014-08-27 | 2017-05-24 | 昂科梅德制药有限公司 | 用于治疗癌症的组合治疗 |
US20180280504A1 (en) | 2014-10-10 | 2018-10-04 | Siamab Therapeutics, Inc. | Glycan-interacting compounds and methods of use |
WO2016057890A1 (fr) | 2014-10-10 | 2016-04-14 | Siamab Therapeutics, Inc. | Analyse et profilage de glycanes |
US9879087B2 (en) | 2014-11-12 | 2018-01-30 | Siamab Therapeutics, Inc. | Glycan-interacting compounds and methods of use |
WO2016077526A1 (fr) | 2014-11-12 | 2016-05-19 | Siamab Therapeutics, Inc. | Composés interagissant avec le glycane et procédés d'utilisation |
US20180334490A1 (en) | 2014-12-03 | 2018-11-22 | Qilong H. Wu | Methods for b cell preconditioning in car therapy |
IL296062A (en) | 2015-03-17 | 2022-10-01 | Memorial Sloan Kettering Cancer Center | Antibodies against muc16 and their uses |
EP3091032A1 (fr) | 2015-05-08 | 2016-11-09 | Miltenyi Biotec GmbH | Anticorps humanisé ou fragment de celui-ci spécifique au cd3 |
US20200041517A1 (en) | 2015-06-12 | 2020-02-06 | Seattle Genetics, Inc. | Compositions and methods for targeting cancer stem cells |
CN116217729A (zh) | 2015-11-12 | 2023-06-06 | 思进公司 | 聚糖相互作用化合物及使用方法 |
US20190031780A1 (en) | 2016-01-27 | 2019-01-31 | Siamab Therapeutics, Inc. | Compositions and methods for targeting cancer stem cells |
US11401330B2 (en) | 2016-11-17 | 2022-08-02 | Seagen Inc. | Glycan-interacting compounds and methods of use |
US20200247902A1 (en) | 2016-11-17 | 2020-08-06 | Seattle Genetics, Inc. | Compositions and methods for treating cancer |
JP2020510671A (ja) | 2017-03-03 | 2020-04-09 | シアトル ジェネティックス, インコーポレイテッド | グリカン相互作用化合物および使用の方法 |
-
2018
- 2018-03-02 JP JP2019547665A patent/JP2020510671A/ja active Pending
- 2018-03-02 MA MA047812A patent/MA47812A/fr unknown
- 2018-03-02 US US16/489,569 patent/US11253609B2/en active Active
- 2018-03-02 BR BR112019018043A patent/BR112019018043A2/pt unknown
- 2018-03-02 CA CA3054939A patent/CA3054939A1/fr active Pending
- 2018-03-02 EP EP18760528.2A patent/EP3589319A4/fr active Pending
- 2018-03-02 SG SG11201907889YA patent/SG11201907889YA/en unknown
- 2018-03-02 WO PCT/US2018/020562 patent/WO2018160909A1/fr active Application Filing
- 2018-03-02 CN CN201880028376.XA patent/CN110913903B/zh active Active
- 2018-03-02 AU AU2018226824A patent/AU2018226824A1/en active Pending
- 2018-03-02 KR KR1020247010200A patent/KR20240044544A/ko active Search and Examination
- 2018-03-02 MX MX2019010202A patent/MX2019010202A/es unknown
- 2018-03-02 KR KR1020197028878A patent/KR102653141B1/ko active IP Right Grant
-
2019
- 2019-08-27 IL IL26896619A patent/IL268966A/en unknown
- 2019-08-27 MX MX2023014093A patent/MX2023014093A/es unknown
- 2019-08-28 ZA ZA2019/05677A patent/ZA201905677B/en unknown
-
2022
- 2022-01-04 US US17/568,195 patent/US20230001007A1/en not_active Abandoned
- 2022-08-10 JP JP2022128246A patent/JP2022160669A/ja active Pending
- 2022-08-10 JP JP2022128245A patent/JP7316421B2/ja active Active
- 2022-11-07 US US18/053,006 patent/US20240000962A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ZA201905677B (en) | 2022-12-21 |
US20230001007A1 (en) | 2023-01-05 |
MX2019010202A (es) | 2019-10-02 |
US11253609B2 (en) | 2022-02-22 |
US20240000962A1 (en) | 2024-01-04 |
JP2022160669A (ja) | 2022-10-19 |
IL268966A (en) | 2019-10-31 |
MX2023014093A (es) | 2023-12-11 |
CA3054939A1 (fr) | 2018-09-07 |
US20200000932A1 (en) | 2020-01-02 |
EP3589319A4 (fr) | 2021-07-14 |
AU2018226824A1 (en) | 2019-09-19 |
BR112019018043A2 (pt) | 2020-04-07 |
EP3589319A1 (fr) | 2020-01-08 |
JP2022160668A (ja) | 2022-10-19 |
CN110913903A (zh) | 2020-03-24 |
CN110913903B (zh) | 2024-03-01 |
KR102653141B1 (ko) | 2024-04-01 |
JP2020510671A (ja) | 2020-04-09 |
JP7316421B2 (ja) | 2023-07-27 |
KR20240044544A (ko) | 2024-04-04 |
KR20190125398A (ko) | 2019-11-06 |
SG11201907889YA (en) | 2019-09-27 |
WO2018160909A1 (fr) | 2018-09-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MA47812A (fr) | Composés interagissant avec le glycane et méthodes d'utilisation | |
MA43284A (fr) | Composés et leurs méthodes d'utilisation | |
MA42925A (fr) | Anticorps anti-tigit et méthodes d'utilisation | |
MA45996A (fr) | Variants d'endonucléase de homing du récepteur alpha de l'il-10, compositions et méthodes d'utilisation associées | |
MA44225A (fr) | Sulfonylurées et composés apparentés et leur utilisation | |
MA50957A (fr) | Anticorps anti-tigit et leurs méthodes d'utilisation | |
MA49288A (fr) | Reactifs particulaires oligomères et leurs méthodes d'utilisation | |
MA45123A (fr) | Anticorps anti-tim-3 et leurs méthodes d'utilisation | |
MA43364A (fr) | Composés d'alcènes tétrasubstitués et leur utilisation | |
DK3452448T3 (da) | Modulatorer af den integrerede stressvej | |
MA43387A (fr) | Anticorps anti-gitr et leurs méthodes d'utilisation | |
MA48579A (fr) | Anticorps anti-pd1 et méthodes d'utilisation de ceux-ci | |
MA43823A (fr) | Inhibiteurs bicycliques pontés de ménine-mll et méthodes d'utilisation | |
MA42243A (fr) | Anticorps de facteur xi et méthodes d'utilisation | |
MA44526A (fr) | Oxystérols et leurs méthodes d'utilisation | |
MA43385A (fr) | Nouveaux anticorps anti-claudine et méthodes d'utilisation | |
MA45709A (fr) | Composés diazahétérobicycliques substitués et leur utilisation | |
DK3355041T3 (da) | Strækbar touchpad af den kapacitive type | |
MA41957A (fr) | Conjugués d'une fraction d'il-7 et d'un polymère | |
MA46422A (fr) | Oligonucléotides modifiés et méthodes d'utilisation | |
MA44087A (fr) | Immunothérapie basée sur la listéria et ses méthodes d'utilisation | |
MA39915B1 (fr) | Composés de pladiénolide pyridine et leurs procédés d'utilisation | |
MA41642A (fr) | Variants de protoxine ii et méthodes d'utilisation | |
MA42118A (fr) | Benzamides substitués et leurs méthodes d'utilisation | |
MA46896A (fr) | Composés d'alcène tétrasubstitués et leur utilisation |