ITRM20020588A1 - Metodo per isolare anticorpi intracellulari neutralizzanti di interazioni proteiche. - Google Patents

Metodo per isolare anticorpi intracellulari neutralizzanti di interazioni proteiche.

Info

Publication number
ITRM20020588A1
ITRM20020588A1 IT000588A ITRM20020588A ITRM20020588A1 IT RM20020588 A1 ITRM20020588 A1 IT RM20020588A1 IT 000588 A IT000588 A IT 000588A IT RM20020588 A ITRM20020588 A IT RM20020588A IT RM20020588 A1 ITRM20020588 A1 IT RM20020588A1
Authority
IT
Italy
Prior art keywords
intra
protein interactions
cell antibodies
neutralizing
isolating
Prior art date
Application number
IT000588A
Other languages
English (en)
Inventor
Antinino Cattaneo
Michela Visintin
Original Assignee
Lay Line Genomics Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lay Line Genomics Spa filed Critical Lay Line Genomics Spa
Priority to IT000588A priority Critical patent/ITRM20020588A1/it
Priority to ES03780645.2T priority patent/ES2526612T3/es
Priority to JP2004553091A priority patent/JP4652057B2/ja
Priority to AU2003288742A priority patent/AU2003288742B2/en
Priority to US10/536,263 priority patent/US20060257925A1/en
Priority to PT37806452T priority patent/PT1565558E/pt
Priority to CA2506890A priority patent/CA2506890C/en
Priority to EP03780645.2A priority patent/EP1565558B1/en
Priority to PCT/IT2003/000764 priority patent/WO2004046192A2/en
Publication of ITRM20020588A1 publication Critical patent/ITRM20020588A1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/80—Immunoglobulins specific features remaining in the (producing) cell, i.e. intracellular antibodies or intrabodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IT000588A 2002-11-21 2002-11-21 Metodo per isolare anticorpi intracellulari neutralizzanti di interazioni proteiche. ITRM20020588A1 (it)

Priority Applications (9)

Application Number Priority Date Filing Date Title
IT000588A ITRM20020588A1 (it) 2002-11-21 2002-11-21 Metodo per isolare anticorpi intracellulari neutralizzanti di interazioni proteiche.
ES03780645.2T ES2526612T3 (es) 2002-11-21 2003-11-21 Método para aislar anticuerpos intracelulares capaces de neutralizar interacciones proteicas
JP2004553091A JP4652057B2 (ja) 2002-11-21 2003-11-21 タンパク質相互作用を中和し得る細胞内抗体を単離するための方法
AU2003288742A AU2003288742B2 (en) 2002-11-21 2003-11-21 Method for isolating intracellular antibodies able to neutralize protein interactions
US10/536,263 US20060257925A1 (en) 2002-11-21 2003-11-21 Method for isolating intracellular antibodies able to neutralize protein interactions
PT37806452T PT1565558E (pt) 2002-11-21 2003-11-21 Método para isolar anticorpos intracelulares capazes de neutralizar interações proteicas
CA2506890A CA2506890C (en) 2002-11-21 2003-11-21 Method for isolating intracellular antibodies able to neutralize protein interactions
EP03780645.2A EP1565558B1 (en) 2002-11-21 2003-11-21 Method for isolating intracellular antibodies able to neutralize protein interactions
PCT/IT2003/000764 WO2004046192A2 (en) 2002-11-21 2003-11-21 Method for isolating intracellular antibodies able to neutralize protein interactions

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT000588A ITRM20020588A1 (it) 2002-11-21 2002-11-21 Metodo per isolare anticorpi intracellulari neutralizzanti di interazioni proteiche.

Publications (1)

Publication Number Publication Date
ITRM20020588A1 true ITRM20020588A1 (it) 2004-05-22

Family

ID=32321450

Family Applications (1)

Application Number Title Priority Date Filing Date
IT000588A ITRM20020588A1 (it) 2002-11-21 2002-11-21 Metodo per isolare anticorpi intracellulari neutralizzanti di interazioni proteiche.

Country Status (9)

Country Link
US (1) US20060257925A1 (it)
EP (1) EP1565558B1 (it)
JP (1) JP4652057B2 (it)
AU (1) AU2003288742B2 (it)
CA (1) CA2506890C (it)
ES (1) ES2526612T3 (it)
IT (1) ITRM20020588A1 (it)
PT (1) PT1565558E (it)
WO (1) WO2004046192A2 (it)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2869416B1 (fr) * 2004-04-27 2007-01-12 Centre Nat Rech Scient Cnrse Procede d'identification d'un ligand capable de moduler selectivement une cascade fonctionnelle impliquant une cible et ses applications pour le criblage a haut-debit de molecules d'interet.
CN101977932B (zh) 2008-01-31 2014-09-03 美国政府健康及人类服务部 工程化抗体恒定结构域分子
US20150010932A1 (en) * 2013-07-02 2015-01-08 Salk Institute For Biological Studies Methods for assaying protein-protein interactions
HUE061672T2 (hu) 2014-11-12 2023-08-28 Seagen Inc Glikán-interakcióban lévõ vegyületek és felhasználási módszerek
US9879087B2 (en) 2014-11-12 2018-01-30 Siamab Therapeutics, Inc. Glycan-interacting compounds and methods of use
ITUB20155272A1 (it) 2015-11-02 2017-05-02 Scuola Normale Superiore Intracellular antibody
JP7066613B2 (ja) 2015-11-12 2022-05-13 シージェン インコーポレイテッド グリカン相互作用化合物および使用方法
WO2018094143A1 (en) 2016-11-17 2018-05-24 Siamab Therapeutics, Inc. Glycan-interacting compounds and methods of use
KR102653141B1 (ko) 2017-03-03 2024-04-01 씨젠 인크. 글리칸-상호작용 화합물 및 사용 방법

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6083693A (en) * 1996-06-14 2000-07-04 Curagen Corporation Identification and comparison of protein-protein interactions that occur in populations
GB2344886B (en) * 1999-03-10 2000-11-01 Medical Res Council Selection of intracellular immunoglobulins
US6878524B2 (en) * 2001-06-08 2005-04-12 Gang Peng Reagents and methods for detection and characterization of protein-protein interactions, nuclear export and localization sequences and inducible Gal4p-mediated gene expression in yeast

Also Published As

Publication number Publication date
EP1565558A2 (en) 2005-08-24
AU2003288742B2 (en) 2011-06-30
CA2506890C (en) 2013-02-12
AU2003288742A1 (en) 2004-06-15
EP1565558B1 (en) 2014-10-29
WO2004046192A3 (en) 2004-12-23
CA2506890A1 (en) 2004-06-03
JP2006518988A (ja) 2006-08-24
PT1565558E (pt) 2015-01-02
ES2526612T3 (es) 2015-01-13
WO2004046192A2 (en) 2004-06-03
US20060257925A1 (en) 2006-11-16
JP4652057B2 (ja) 2011-03-16

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