EA020556B1 - ПРОИЗВОДНЫЕ 7-АРИЛ-1,2,4-ТРИАЗОЛО[4,3-a]ПИРИДИНА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ПОЛОЖИТЕЛЬНЫХ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ mGluR2 - Google Patents

ПРОИЗВОДНЫЕ 7-АРИЛ-1,2,4-ТРИАЗОЛО[4,3-a]ПИРИДИНА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ПОЛОЖИТЕЛЬНЫХ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ mGluR2 Download PDF

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Publication number
EA020556B1
EA020556B1 EA201190302A EA201190302A EA020556B1 EA 020556 B1 EA020556 B1 EA 020556B1 EA 201190302 A EA201190302 A EA 201190302A EA 201190302 A EA201190302 A EA 201190302A EA 020556 B1 EA020556 B1 EA 020556B1
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Eurasian Patent Office
Prior art keywords
chloro
mmol
compound
triazolo
disorders
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EA201190302A
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English (en)
Russian (ru)
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EA201190302A1 (ru
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Хосе Мария Сид-Нуньес
Ана Изабель Де Лукас Оливарес
Андрес Авелино Трабанко-Суарес
Грегор Джеймс Макдональд
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Янссен Фармасьютикалс, Инк.
Аддекс Фарма С.А.
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Publication of EA201190302A1 publication Critical patent/EA201190302A1/ru
Publication of EA020556B1 publication Critical patent/EA020556B1/ru

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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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EA201190302A 2009-05-12 2010-05-11 ПРОИЗВОДНЫЕ 7-АРИЛ-1,2,4-ТРИАЗОЛО[4,3-a]ПИРИДИНА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ПОЛОЖИТЕЛЬНЫХ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ mGluR2 EA020556B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09160064 2009-05-12
PCT/EP2010/002909 WO2010130423A1 (en) 2009-05-12 2010-05-11 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors

Publications (2)

Publication Number Publication Date
EA201190302A1 EA201190302A1 (ru) 2012-06-29
EA020556B1 true EA020556B1 (ru) 2014-12-30

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EA201190302A EA020556B1 (ru) 2009-05-12 2010-05-11 ПРОИЗВОДНЫЕ 7-АРИЛ-1,2,4-ТРИАЗОЛО[4,3-a]ПИРИДИНА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ПОЛОЖИТЕЛЬНЫХ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ mGluR2

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US (2) US8716480B2 (https=)
EP (1) EP2430021B1 (https=)
JP (1) JP5707391B2 (https=)
KR (1) KR20120039532A (https=)
CN (1) CN102439009B (https=)
AR (1) AR076860A1 (https=)
AU (1) AU2010246608B2 (https=)
CA (1) CA2760084C (https=)
CL (1) CL2011002839A1 (https=)
EA (1) EA020556B1 (https=)
ES (1) ES2428401T3 (https=)
IL (1) IL215911A (https=)
MX (1) MX2011011963A (https=)
MY (1) MY153913A (https=)
NZ (1) NZ595945A (https=)
SG (1) SG175931A1 (https=)
TW (1) TW201100415A (https=)
WO (1) WO2010130423A1 (https=)
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GB0420722D0 (en) 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
AR059898A1 (es) 2006-03-15 2008-05-07 Janssen Pharmaceutica Nv Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
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