DK2666859T3
(da)
|
2006-04-03 |
2019-04-08 |
Roche Innovation Ct Copenhagen As |
FARMACEUTISK SAMMENSÆTNING, DER OMFATTER ANTI-miRNA-ANTISENSE-OLIGONUKLEOTIDER
|
CN102851291B
(zh)
|
2006-04-03 |
2016-03-09 |
斯特拉有限责任公司 |
包含抗微小rna反义寡核苷酸的药物组合物
|
EP2410053B2
(en)
†
|
2006-10-18 |
2020-07-15 |
Ionis Pharmaceuticals, Inc. |
Antisense compounds
|
WO2008111908A1
(en)
*
|
2007-03-15 |
2008-09-18 |
Jyoti Chattopadhyaya |
Five- and six-membered conformationally locked 2',4'- carbocyclic ribo-thymidines for the treatment of infections and cancer
|
CA2681406A1
(en)
|
2007-03-22 |
2008-09-25 |
Santaris Pharma A/S |
Rna antagonist compounds for the inhibition of apo-b100 expression
|
US8580756B2
(en)
|
2007-03-22 |
2013-11-12 |
Santaris Pharma A/S |
Short oligomer antagonist compounds for the modulation of target mRNA
|
EP2188298B1
(en)
|
2007-08-15 |
2013-09-18 |
Isis Pharmaceuticals, Inc. |
Tetrahydropyran nucleic acid analogs
|
ES2463665T3
(es)
|
2007-10-04 |
2014-05-28 |
Stella Aps |
Tratamiento de combinación para el tratamiento de infección por virus de la hepatitis C
|
CA2717792A1
(en)
|
2008-03-07 |
2009-09-11 |
Santaris Pharma A/S |
Pharmaceutical compositions for treatment of microrna related diseases
|
EP2282744B1
(en)
|
2008-03-21 |
2018-01-17 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds comprising tricyclic nucleosides and methods for their use
|
EP2285819B1
(en)
|
2008-04-04 |
2013-10-16 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising neutrally linked terminal bicyclic nucleosides
|
WO2010012667A1
(en)
|
2008-08-01 |
2010-02-04 |
Santaris Pharma A/S |
Micro-rna mediated modulation of colony stimulating factors
|
US8604192B2
(en)
|
2008-09-24 |
2013-12-10 |
Isis Pharmaceuticals, Inc. |
Cyclohexenyl nucleic acids analogs
|
CA2966011C
(en)
|
2008-10-15 |
2021-10-19 |
Ionis Pharmaceuticals, Inc. |
Modulation of factor 11 expression
|
CN102264374B
(zh)
|
2008-10-24 |
2015-01-07 |
Isis制药公司 |
5′和2′双取代的核苷和由其制备的低聚化合物
|
US8987435B2
(en)
|
2008-10-24 |
2015-03-24 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and methods
|
KR101881596B1
(ko)
|
2008-12-02 |
2018-07-24 |
웨이브 라이프 사이언시스 재팬 인코포레이티드 |
인 원자 변형된 핵산의 합성 방법
|
JP5793423B2
(ja)
|
2008-12-31 |
2015-10-14 |
ロシュ・イノベーション・センター・コペンハーゲン・アクティーゼルスカブRoche Innovation Center Copenhagen A/S |
急性冠症候群の治療のためのLNAApoBアンチセンスオリゴマーの使用
|
US20120021515A1
(en)
|
2009-02-06 |
2012-01-26 |
Swayze Eric E |
Oligomeric compounds and methods
|
WO2010090969A1
(en)
|
2009-02-06 |
2010-08-12 |
Isis Pharmaceuticals, Inc. |
Tetrahydropyran nucleic acid analogs
|
JP5773535B2
(ja)
|
2009-04-24 |
2015-09-02 |
ロシュ・イノベーション・センター・コペンハーゲン・アクティーゼルスカブRoche Innovation Center Copenhagen A/S |
インターフェロンに非応答性のhcv患者の治療のための医薬組成物
|
NZ596608A
(en)
|
2009-06-12 |
2014-01-31 |
Santaris Pharma As |
New potent anti apob antisense compounds
|
NZ597071A
(en)
|
2009-06-17 |
2014-05-30 |
Isis Pharmaceuticals Inc |
Compositions and methods for modulation of smn2 splicing in a subject
|
SG177564A1
(en)
|
2009-07-06 |
2012-02-28 |
Ontorii Inc |
Novel nucleic acid prodrugs and methods of use thereof
|
EP2456870A1
(en)
|
2009-07-21 |
2012-05-30 |
Santaris Pharma A/S |
Antisense oligomers targeting pcsk9
|
US9012421B2
(en)
|
2009-08-06 |
2015-04-21 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexose nucleic acid analogs
|
WO2011048125A1
(en)
|
2009-10-20 |
2011-04-28 |
Santaris Pharma A/S |
Oral delivery of therapeutically effective lna oligonucleotides
|
WO2011054811A1
(en)
|
2009-11-03 |
2011-05-12 |
Santaris Pharma A/S |
Rna antagonists targeting hsp27 combination therapy
|
US8779118B2
(en)
|
2010-01-11 |
2014-07-15 |
Isis Pharmaceuticals, Inc. |
Base modified bicyclic nucleosides and oligomeric compounds prepared therefrom
|
US8957040B2
(en)
|
2010-02-08 |
2015-02-17 |
Isis Pharmaceuticals, Inc. |
Selective reduction of allelic variants
|
JP6018506B2
(ja)
|
2010-02-08 |
2016-11-02 |
アイオーニス ファーマシューティカルズ, インコーポレーテッドIonis Pharmaceuticals,Inc. |
対立遺伝子多様体の選択的低減
|
WO2011115817A1
(en)
|
2010-03-16 |
2011-09-22 |
Isis Pharmaceuticals, Inc. |
Methods of preparing 2'-o-substituted purine nucleosides
|
WO2011115818A1
(en)
|
2010-03-17 |
2011-09-22 |
Isis Pharmaceuticals, Inc. |
5'-substituted bicyclic nucleosides and oligomeric compounds prepared therefrom
|
EP3091027B1
(en)
|
2010-04-28 |
2018-01-17 |
Ionis Pharmaceuticals, Inc. |
5' modified nucleosides and oligomeric compounds prepared therefrom
|
WO2011139695A2
(en)
|
2010-04-28 |
2011-11-10 |
Isis Pharmaceuticals, Inc. |
Modified 5' diphosphate nucleosides and oligomeric compounds prepared therefrom
|
EP2601204B1
(en)
|
2010-04-28 |
2016-09-07 |
Ionis Pharmaceuticals, Inc. |
Modified nucleosides and oligomeric compounds prepared therefrom
|
US20130156845A1
(en)
|
2010-04-29 |
2013-06-20 |
Alnylam Pharmaceuticals, Inc. |
Lipid formulated single stranded rna
|
WO2011139917A1
(en)
|
2010-04-29 |
2011-11-10 |
Isis Pharmaceuticals, Inc. |
Modulation of transthyretin expression
|
US8957200B2
(en)
|
2010-06-07 |
2015-02-17 |
Isis Pharmaceuticals, Inc. |
Bicyclic nucleosides and oligomeric compounds prepared therefrom
|
WO2011156202A1
(en)
|
2010-06-08 |
2011-12-15 |
Isis Pharmaceuticals, Inc. |
Substituted 2 '-amino and 2 '-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
|
US9518259B2
(en)
|
2010-06-15 |
2016-12-13 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating interaction between proteins and target nucleic acids
|
WO2012007477A1
(en)
|
2010-07-12 |
2012-01-19 |
Santaris Pharma A/S |
Anti hcv oligomers
|
WO2012012467A2
(en)
|
2010-07-19 |
2012-01-26 |
Isis Pharmaceuticals, Inc. |
Modulation of nuclear-retained rna
|
WO2012034942A1
(en)
|
2010-09-13 |
2012-03-22 |
Santaris Pharma A/S |
Compounds for the modulation of aurora kinase b expression
|
WO2012039448A1
(ja)
|
2010-09-24 |
2012-03-29 |
株式会社キラルジェン |
不斉補助基
|
US8648053B2
(en)
|
2010-10-20 |
2014-02-11 |
Rosalind Franklin University Of Medicine And Science |
Antisense oligonucleotides that target a cryptic splice site in Ush1c as a therapeutic for Usher syndrome
|
WO2012064758A2
(en)
|
2010-11-08 |
2012-05-18 |
Isis Pharmaceuticals, Inc. |
Methods for modulating factor 12 expression
|
WO2012068405A2
(en)
|
2010-11-17 |
2012-05-24 |
Isis Pharmaceuticals, Inc. |
Modulation of alpha synuclein expression
|
WO2012066092A1
(en)
|
2010-11-19 |
2012-05-24 |
Santaris Pharma A/S |
Compounds for the modulation of aurora kinase a expression
|
WO2012066093A1
(en)
|
2010-11-19 |
2012-05-24 |
Santaris Pharma A/S |
Compounds for the modulation of pdz-binding kinase (pbk) expression
|
US10017764B2
(en)
|
2011-02-08 |
2018-07-10 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleotides and uses thereof
|
WO2012110457A2
(en)
|
2011-02-14 |
2012-08-23 |
Santaris Pharma A/S |
Compounds for the modulation of osteopontin expression
|
KR102050469B1
(ko)
|
2011-04-01 |
2019-12-02 |
아이오니스 파마수티컬즈, 인코포레이티드 |
전사 신호 전달 인자 및 활성 인자 3(stat3) 발현 조절
|
AU2012242642A1
(en)
|
2011-04-13 |
2013-05-02 |
Ionis Pharmaceuticals, Inc. |
Antisense modulation of PTP1B expression
|
WO2012143427A1
(en)
|
2011-04-19 |
2012-10-26 |
Santaris Pharma A/S |
Anti polyomavirus compounds
|
CN111172162A
(zh)
|
2011-04-21 |
2020-05-19 |
葛兰素史克公司 |
乙型肝炎病毒(hbv)表达的调节
|
CN113249381A
(zh)
|
2011-04-25 |
2021-08-13 |
赛诺菲 |
用于调节mir-21活性的微rna化合物以及方法
|
RU2603076C9
(ru)
|
2011-04-27 |
2017-02-03 |
Айсис Фармасьютикалс, Инк. |
Модулирование экспрессии аполипопротеина сiii (аросiii)
|
US9353371B2
(en)
|
2011-05-02 |
2016-05-31 |
Ionis Pharmaceuticals, Inc. |
Antisense compounds targeting genes associated with usher syndrome
|
WO2012170347A1
(en)
|
2011-06-09 |
2012-12-13 |
Isis Pharmaceuticals, Inc. |
Bicyclic nucleosides and oligomeric compounds prepared therefrom
|
EP2717923B1
(en)
|
2011-06-10 |
2017-09-27 |
Ionis Pharmaceuticals, Inc. |
Methods for modulating kallikrein (klkb1) expression
|
US9187749B2
(en)
|
2011-06-10 |
2015-11-17 |
Isis Pharmaceuticals, Inc. |
Methods for modulating factor 12 expression
|
CN103597074A
(zh)
|
2011-06-16 |
2014-02-19 |
Isis制药公司 |
成纤维细胞生长因子受体4表达的反义调节
|
KR20140051271A
(ko)
|
2011-06-23 |
2014-04-30 |
스텔라 에이피에스 |
Hcv 조합 치료
|
CA2840614A1
(en)
|
2011-06-29 |
2013-01-03 |
Isis Pharmaceuticals, Inc. |
Methods for modulating kallikrein (klkb1) expression
|
WO2013000856A1
(en)
|
2011-06-30 |
2013-01-03 |
Santaris Pharma A/S |
Hcv combination therapy
|
EP2726610A1
(en)
|
2011-06-30 |
2014-05-07 |
Stella ApS |
Hcv combination therapy
|
EP2734208B1
(en)
|
2011-07-19 |
2017-03-01 |
Wave Life Sciences Ltd. |
Methods for the synthesis of functionalized nucleic acids
|
US10202599B2
(en)
|
2011-08-11 |
2019-02-12 |
Ionis Pharmaceuticals, Inc. |
Selective antisense compounds and uses thereof
|
EP2751269B1
(en)
|
2011-08-29 |
2016-03-23 |
Ionis Pharmaceuticals, Inc. |
Methods and compounds useful in conditions related to repeat expansion
|
US10023861B2
(en)
|
2011-08-29 |
2018-07-17 |
Ionis Pharmaceuticals, Inc. |
Oligomer-conjugate complexes and their use
|
CN103814132B
(zh)
|
2011-09-20 |
2018-06-05 |
苏州瑞博生物技术有限公司 |
Gcgr表达的反义调节
|
CN103906838A
(zh)
|
2011-10-25 |
2014-07-02 |
Isis制药公司 |
Gccr表达的反义调节
|
WO2013068348A1
(en)
|
2011-11-07 |
2013-05-16 |
Santaris Pharma A/S |
Lna oligomers for improvement in hepatic function
|
US9725722B2
(en)
|
2011-11-07 |
2017-08-08 |
Ionis Pharmaceuticals, Inc. |
Modulation of TMPRSS6 expression
|
DK2776590T3
(da)
|
2011-11-07 |
2016-12-05 |
Roche Innovation Ct Copenhagen As |
Prognostisk fremgangsmåde til vurdering af virkningsfuldheden af mikro rna-122 inhibitorer i hcv+-patienter
|
EA201400566A1
(ru)
|
2011-11-11 |
2014-09-30 |
Сэнтерис Фарма А/С |
Соединения, предназначенные для модуляции сплайсинга smn2
|
AU2012358238B2
(en)
|
2011-12-22 |
2017-12-07 |
C. Frank Bennett |
Methods for modulating Metastasis-Associated-in-Lung-Adenocarcinoma-Transcript-1(MALAT-1) expression
|
ES2842938T3
(es)
|
2012-01-11 |
2021-07-15 |
Ionis Pharmaceuticals Inc |
Composiciones y métodos para la modulación del empalme de IKBKAP
|
EP2812342B1
(en)
|
2012-02-08 |
2017-11-15 |
Ionis Pharmaceuticals, Inc. |
Modulation of rna by repeat targeting
|
WO2013142514A1
(en)
|
2012-03-19 |
2013-09-26 |
Isis Pharmaceuticals, Inc. |
Methods and compositions for modulating alpha-1-antitrypsin expression
|
WO2013148260A1
(en)
|
2012-03-30 |
2013-10-03 |
Washington University |
Methods for modulating tau expression for reducing seizure and modifying a neurodegenerative syndrome
|
WO2013154799A1
(en)
|
2012-04-09 |
2013-10-17 |
Isis Pharmaceuticals, Inc. |
Tricyclic nucleosides and oligomeric compounds prepared therefrom
|
EP2850092B1
(en)
|
2012-04-09 |
2017-03-01 |
Ionis Pharmaceuticals, Inc. |
Tricyclic nucleic acid analogs
|
WO2013159108A2
(en)
|
2012-04-20 |
2013-10-24 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleotides and uses thereof
|
NZ630591A
(en)
|
2012-04-25 |
2017-02-24 |
Regulus Therapeutics Inc |
Microrna compounds and methods for modulating mir-21 activity
|
US9574193B2
(en)
|
2012-05-17 |
2017-02-21 |
Ionis Pharmaceuticals, Inc. |
Methods and compositions for modulating apolipoprotein (a) expression
|
US20160002624A1
(en)
|
2012-05-17 |
2016-01-07 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide compositions
|
US9518261B2
(en)
|
2012-05-22 |
2016-12-13 |
Ionis Pharmaceuticals, Inc. |
Modulation of enhancer RNA mediated gene expression
|
KR20190084354A
(ko)
|
2012-05-24 |
2019-07-16 |
아이오니스 파마수티컬즈, 인코포레이티드 |
아포지질단백질 (a) 발현을 조절하는 방법들 및 조성물들
|
US9487780B2
(en)
|
2012-06-01 |
2016-11-08 |
Ionis Pharmaceuticals, Inc. |
Antisense compounds targeting genes associated with fibronectin
|
WO2013181665A1
(en)
|
2012-06-01 |
2013-12-05 |
Isis Pharmaceuticals, Inc. |
Antisense compounds targeting genes associated with fibronectin
|
ES2688831T3
(es)
|
2012-06-25 |
2018-11-07 |
Ionis Pharmaceuticals, Inc. |
Modulación de la expresión de UBE3A-ATS
|
EP2872485B1
(en)
|
2012-07-13 |
2020-12-16 |
Wave Life Sciences Ltd. |
Asymmetric auxiliary group
|
WO2014010718A1
(ja)
|
2012-07-13 |
2014-01-16 |
株式会社新日本科学 |
キラル核酸アジュバント
|
KR102213609B1
(ko)
|
2012-07-13 |
2021-02-08 |
웨이브 라이프 사이언시스 리미티드 |
키랄 제어
|
EP3693460A1
(en)
|
2012-07-27 |
2020-08-12 |
Ionis Pharmaceuticals, Inc. |
Modulation of renin-angiotensin system (ras) related diseases by angiotensinogen
|
KR102237882B1
(ko)
|
2012-08-15 |
2021-04-07 |
아이오니스 파마수티컬즈, 인코포레이티드 |
변형된 캡핑 프로토콜을 이용하는 올리고머 화합물 제조 방법
|
US9175291B2
(en)
|
2012-10-11 |
2015-11-03 |
Isis Pharmaceuticals Inc. |
Modulation of androgen receptor expression
|
EP4052709A1
(en)
|
2012-10-11 |
2022-09-07 |
Ionis Pharmaceuticals, Inc. |
Methods of treating kennedy's disease
|
WO2014059353A2
(en)
|
2012-10-11 |
2014-04-17 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleosides and uses thereof
|
EP2906255B1
(en)
|
2012-10-12 |
2023-02-22 |
Ionis Pharmaceuticals, Inc. |
Antisense compounds and uses thereof
|
US20150275208A1
(en)
|
2012-10-12 |
2015-10-01 |
Isis Pharmaceuticals, Inc. |
Selective antisense compounds and uses thereof
|
CA2888486A1
(en)
|
2012-10-15 |
2014-04-24 |
Isis Pharmaceuticals, Inc. |
Compositions for modulating c9orf72 expression
|
WO2014062686A1
(en)
|
2012-10-15 |
2014-04-24 |
Isis Pharmaceuticals, Inc. |
Methods for modulating c9orf72 expression
|
WO2014062736A1
(en)
|
2012-10-15 |
2014-04-24 |
Isis Pharmaceuticals, Inc. |
Methods for monitoring c9orf72 expression
|
US9029335B2
(en)
|
2012-10-16 |
2015-05-12 |
Isis Pharmaceuticals, Inc. |
Substituted 2′-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
|
US10723754B2
(en)
|
2012-10-22 |
2020-07-28 |
Idenix Pharmaceuticals Llc |
2′,4′-bridged nucleosides for HCV infection
|
HUE041632T2
(hu)
|
2012-10-31 |
2019-05-28 |
Ionis Pharmaceuticals Inc |
Rákkezelés
|
US20150291958A1
(en)
|
2012-11-15 |
2015-10-15 |
Roche Innovation Center Copenhagen A/S |
Anti apob antisense conjugate compounds
|
KR20150088305A
(ko)
|
2012-11-26 |
2015-07-31 |
로슈 이노베이션 센터 코펜하겐 에이/에스 |
Fgfr3 발현의 조절을 위한 조성물 및 방법
|
US9695475B2
(en)
|
2012-12-11 |
2017-07-04 |
Ionis Pharmaceuticals, Inc. |
Competitive modulation of microRNAs
|
WO2014118272A1
(en)
|
2013-01-30 |
2014-08-07 |
Santaris Pharma A/S |
Antimir-122 oligonucleotide carbohydrate conjugates
|
RU2018108405A
(ru)
|
2013-01-30 |
2019-02-26 |
Ф. Хоффманн-Ля Рош Аг |
Конъюгаты углевода и lna-олигонуклеотида
|
US9701708B2
(en)
|
2013-01-31 |
2017-07-11 |
Ionis Pharmaceuticals, Inc. |
Method of preparing oligomeric compounds using modified coupling protocols
|
WO2014121287A2
(en)
|
2013-02-04 |
2014-08-07 |
Isis Pharmaceuticals, Inc. |
Selective antisense compounds and uses thereof
|
AU2014216137B2
(en)
|
2013-02-14 |
2018-05-10 |
Ionis Pharmaceuticals, Inc. |
Modulation of Apolipoprotein C-III (ApoCIII) expression in lipoprotein lipase deficient (LPLD) populations
|
BR112015022156A2
(pt)
|
2013-03-14 |
2017-11-14 |
Isis Pharmaceuticals Inc |
composições e métodos para modular a expressão de tau
|
WO2014172698A1
(en)
|
2013-04-19 |
2014-10-23 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for modulation nucleic acids through nonsense mediated decay
|
CA2909868C
(en)
|
2013-05-01 |
2021-10-19 |
Regulus Therapeutics Inc. |
Compounds and methods for enhanced cellular uptake
|
AU2014259759B2
(en)
|
2013-05-01 |
2020-06-18 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods
|
TW201446791A
(zh)
|
2013-05-01 |
2014-12-16 |
Regulus Therapeutics Inc |
用於調節mir-122之微小rna化合物及方法
|
WO2014188001A1
(en)
|
2013-05-24 |
2014-11-27 |
Santaris Pharma A/S |
Oligonucleotide modulators of b-cell cll/lymphoma 11a (bcl11a) and uses thereof
|
WO2014205449A2
(en)
|
2013-06-21 |
2014-12-24 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating apolipoprotein c-iii expression for improving a diabetic profile
|
WO2014205451A2
(en)
|
2013-06-21 |
2014-12-24 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for modulation of target nucleic acids
|
EP3591054A1
(en)
|
2013-06-27 |
2020-01-08 |
Roche Innovation Center Copenhagen A/S |
Antisense oligomers and conjugates targeting pcsk9
|
RU2700244C2
(ru)
|
2013-07-02 |
2019-09-13 |
Ионис Фармасьютикалз, Инк. |
Модуляторы рецептора гормона роста
|
JP6617702B2
(ja)
|
2013-07-15 |
2019-12-11 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
Fty720のアザサイクリック拘束アナログ
|
TWI657819B
(zh)
|
2013-07-19 |
2019-05-01 |
美商Ionis製藥公司 |
用於調節τ蛋白表現之組合物
|
EP3027617A4
(en)
|
2013-07-31 |
2017-04-12 |
Ionis Pharmaceuticals, Inc. |
Methods and compounds useful in conditions related to repeat expansion
|
AU2014306271A1
(en)
|
2013-08-08 |
2016-03-24 |
The Scripps Research Institute |
A method for the site-specific enzymatic labelling of nucleic acids in vitro by incorporation of unnatural nucleotides
|
TW201536329A
(zh)
|
2013-08-09 |
2015-10-01 |
Isis Pharmaceuticals Inc |
用於調節失養性肌強直蛋白質激酶(dmpk)表現之化合物及方法
|
JP6652922B2
(ja)
|
2013-08-28 |
2020-02-26 |
アイオーニス ファーマシューティカルズ, インコーポレーテッドIonis Pharmaceuticals,Inc. |
プレカリクレイン(pkk)発現の調節
|
PE20190354A1
(es)
|
2013-09-13 |
2019-03-07 |
Ionis Pharmaceuticals Inc |
Moduladores del factor del complemento b
|
WO2015042447A1
(en)
|
2013-09-20 |
2015-03-26 |
Isis Pharmaceuticals, Inc. |
Targeted therapeutic nucleosides and their use
|
SG11201602597YA
(en)
|
2013-10-11 |
2016-05-30 |
Ionis Pharmaceuticals Inc |
Compositions for modulating c9orf72 expression
|
US11162096B2
(en)
|
2013-10-14 |
2021-11-02 |
Ionis Pharmaceuticals, Inc |
Methods for modulating expression of C9ORF72 antisense transcript
|
US9758546B2
(en)
|
2013-10-21 |
2017-09-12 |
Ionis Pharmaceuticals, Inc. |
Method for solution phase detritylation of oligomeric compounds
|
WO2015061536A1
(en)
|
2013-10-25 |
2015-04-30 |
Regulus Therapeutics Inc. |
Microrna compounds and methods for modulating mir-21 activity
|
DK3077510T3
(da)
|
2013-12-02 |
2020-06-08 |
Ionis Pharmaceuticals Inc |
Antisense-forbindelser og anvendelser deraf
|
CN105814205B
(zh)
|
2013-12-12 |
2019-11-19 |
阿尔尼拉姆医药品有限公司 |
补体成分iRNA组合物及其使用方法
|
AU2014369900B2
(en)
|
2013-12-24 |
2021-05-20 |
Ionis Pharmaceuticals, Inc. |
Modulation of angiopoietin-like 3 expression
|
JPWO2015108048A1
(ja)
|
2014-01-15 |
2017-03-23 |
株式会社新日本科学 |
抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
|
JPWO2015108046A1
(ja)
|
2014-01-15 |
2017-03-23 |
株式会社新日本科学 |
抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤
|
WO2015108047A1
(ja)
|
2014-01-15 |
2015-07-23 |
株式会社新日本科学 |
免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
|
AU2015207773B2
(en)
|
2014-01-16 |
2021-06-17 |
Wave Life Sciences Ltd. |
Chiral design
|
EA201691587A1
(ru)
|
2014-02-11 |
2017-01-30 |
Элнилэм Фармасьютикалз, Инк. |
КОМПОЗИЦИИ НА ОСНОВЕ iRNA ДЛЯ КЕТОГЕКСОКИНАЗЫ (KHK) И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
|
US10036019B2
(en)
|
2014-03-17 |
2018-07-31 |
Ionis Pharmaceuticals, Inc. |
Bicyclic carbocyclic nucleosides and oligomeric compounds prepared therefrom
|
DK3119888T3
(da)
|
2014-03-19 |
2021-09-06 |
Ionis Pharmaceuticals Inc |
Sammensætninger til at modulere ataxin-2-ekspression
|
US10006027B2
(en)
|
2014-03-19 |
2018-06-26 |
Ionis Pharmaceuticals, Inc. |
Methods for modulating Ataxin 2 expression
|
EP3757214B1
(en)
|
2014-04-01 |
2022-06-15 |
Biogen MA Inc. |
Compositions for modulating sod-1 expression
|
DK3129493T3
(da)
|
2014-04-09 |
2021-09-27 |
Scripps Research Inst |
Import af unaturlige eller modificerede nukleosidtriphosphater ind i celler via nukleinsyre-triphosphat-transportører
|
WO2015164693A1
(en)
|
2014-04-24 |
2015-10-29 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising alpha-beta-constrained nucleic acid
|
WO2015168172A1
(en)
|
2014-04-28 |
2015-11-05 |
Isis Pharmaceuticals, Inc. |
Linkage modified oligomeric compounds
|
EP3845547A1
(en)
|
2014-05-01 |
2021-07-07 |
Ionis Pharmaceuticals, Inc. |
Galnac3 conjugated modified oligonucleotide for modulating angiopoietin-like 3 expression
|
PL3608406T3
(pl)
|
2014-05-01 |
2023-05-22 |
Ionis Pharmaceuticals, Inc. |
Kompozycje i sposoby modulowania ekspresji czynnika B dopełniacza
|
MX2016014140A
(es)
|
2014-05-01 |
2017-09-15 |
Ionis Pharmaceuticals Inc |
Composiciones y metodos para modular la expresion de pkk.
|
JP6667453B2
(ja)
|
2014-05-01 |
2020-03-18 |
アイオーニス ファーマシューティカルズ, インコーポレーテッドIonis Pharmaceuticals,Inc. |
成長ホルモン受容体発現を調節するための組成物及び方法
|
WO2015168514A1
(en)
|
2014-05-01 |
2015-11-05 |
Isis Pharmaceuticals, Inc. |
Method for synthesis of reactive conjugate clusters
|
TW201607559A
(zh)
|
2014-05-12 |
2016-03-01 |
阿尼拉製藥公司 |
治療serpinc1相關疾患之方法和組成物
|
GB201408623D0
(en)
|
2014-05-15 |
2014-07-02 |
Santaris Pharma As |
Oligomers and oligomer conjugates
|
KR20220087576A
(ko)
|
2014-05-22 |
2022-06-24 |
알닐람 파마슈티칼스 인코포레이티드 |
안지오텐시노겐 (agt) irna 조성물 및 이의 사용 방법
|
WO2015179693A1
(en)
|
2014-05-22 |
2015-11-26 |
Isis Pharmaceuticals, Inc. |
Conjugated antisense compounds and their use
|
GB201410693D0
(en)
|
2014-06-16 |
2014-07-30 |
Univ Southampton |
Splicing modulation
|
US9487783B2
(en)
|
2014-08-07 |
2016-11-08 |
Regulus Therapeutics Inc. |
Targeting microRNAs for metabolic disorders
|
WO2016024205A1
(en)
|
2014-08-15 |
2016-02-18 |
Pfizer Inc. |
Oligomers targeting hexanucleotide repeat expansion in human c9orf72 gene
|
EP3191591A1
(en)
|
2014-09-12 |
2017-07-19 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotide agents targeting complement component c5 and methods of use thereof
|
US9976143B2
(en)
|
2014-10-03 |
2018-05-22 |
Cold Spring Harbor Laboratory |
Targeted augmentation of nuclear gene output
|
KR20170068469A
(ko)
|
2014-10-10 |
2017-06-19 |
에프. 호프만-라 로슈 아게 |
GalNAc 포스포라미다이트, 그의 핵산 컨쥬게이트 및 그의 용도
|
EP3207138B1
(en)
|
2014-10-17 |
2020-07-15 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotide agents targeting aminolevulinic acid synthase-1 (alas1) and uses thereof
|
EP3212794B1
(en)
|
2014-10-30 |
2021-04-07 |
Genzyme Corporation |
Polynucleotide agents targeting serpinc1 (at3) and methods of use thereof
|
JOP20200092A1
(ar)
|
2014-11-10 |
2017-06-16 |
Alnylam Pharmaceuticals Inc |
تركيبات iRNA لفيروس الكبد B (HBV) وطرق لاستخدامها
|
US10287584B2
(en)
|
2014-11-12 |
2019-05-14 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for the modulation of COMP
|
WO2016077704A1
(en)
|
2014-11-14 |
2016-05-19 |
The Regents Of The University Of California |
Modulation of agpat5 expression
|
EP3020813A1
(en)
|
2014-11-16 |
2016-05-18 |
Neurovision Pharma GmbH |
Antisense-oligonucleotides as inhibitors of TGF-R signaling
|
EP3221451A1
(en)
|
2014-11-17 |
2017-09-27 |
Alnylam Pharmaceuticals, Inc. |
Apolipoprotein c3 (apoc3) irna compositions and methods of use thereof
|
US10400243B2
(en)
|
2014-11-25 |
2019-09-03 |
Ionis Pharmaceuticals, Inc. |
Modulation of UBE3A-ATS expression
|
EP3229842B1
(en)
|
2014-12-08 |
2022-07-06 |
The Board of Regents of The University of Texas System |
Lipocationic polymers and uses thereof
|
CN107208092B
(zh)
|
2014-12-16 |
2021-09-10 |
罗氏创新中心哥本哈根有限公司 |
手性毒性筛选方法
|
US9688707B2
(en)
|
2014-12-30 |
2017-06-27 |
Ionis Pharmaceuticals, Inc. |
Bicyclic morpholino compounds and oligomeric compounds prepared therefrom
|
WO2016112132A1
(en)
|
2015-01-06 |
2016-07-14 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of c9orf72 antisense transcript
|
WO2016115490A1
(en)
|
2015-01-16 |
2016-07-21 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulation of dux4
|
ES2893114T3
(es)
|
2015-02-04 |
2022-02-08 |
Bristol Myers Squibb Co |
Métodos para seleccionar moléculas terapéuticas
|
RU2017127609A
(ru)
|
2015-02-04 |
2019-03-04 |
Ф. Хоффманн-Ля Рош Аг |
Антисмысловые олигомеры тау-белка и их применение
|
JP2018510621A
(ja)
|
2015-02-13 |
2018-04-19 |
アルナイラム ファーマシューティカルズ, インコーポレイテッドAlnylam Pharmaceuticals, Inc. |
パタチン様ホスホリパーゼドメイン含有3(PNPLA3)iRNA組成物およびその使用方法
|
AU2016222546B2
(en)
|
2015-02-26 |
2020-01-23 |
Ionis Pharmaceuticals, Inc. |
Allele specific modulators of P23H rhodopsin
|
ES2909308T3
(es)
|
2015-03-03 |
2022-05-06 |
Ionis Pharmaceuticals Inc |
Métodos para modular la expresión de MECP2
|
EP3265098A4
(en)
|
2015-03-03 |
2019-02-13 |
Ionis Pharmaceuticals, Inc. |
COMPOSITIONS FOR MODULATING MECP2 EXPRESSION
|
US11129844B2
(en)
|
2015-03-03 |
2021-09-28 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulating MECP2 expression
|
JP6833705B2
(ja)
|
2015-04-03 |
2021-02-24 |
アイオーニス ファーマシューティカルズ, インコーポレーテッドIonis Pharmaceuticals,Inc. |
Tmprss6発現を調節するための化合物及び方法
|
US10745702B2
(en)
|
2015-04-08 |
2020-08-18 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the LECT2 gene
|
WO2016167780A1
(en)
|
2015-04-16 |
2016-10-20 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of c9orf72 antisense transcript
|
PL3283080T3
(pl)
|
2015-04-16 |
2020-07-27 |
Ionis Pharmaceuticals, Inc. |
Kompozycja do modulowania ekspresji c9orf72
|
WO2016201301A1
(en)
|
2015-06-12 |
2016-12-15 |
Alnylam Pharmaceuticals, Inc. |
Complement component c5 irna compositions and methods of use thereof
|
EP3310918B1
(en)
|
2015-06-18 |
2020-08-05 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotide agents targeting hydroxyacid oxidase (glycolate oxidase, hao1) and methods of use thereof
|
WO2016209862A1
(en)
|
2015-06-23 |
2016-12-29 |
Alnylam Pharmaceuticals, Inc. |
Glucokinase (gck) irna compositions and methods of use thereof
|
JP2018519811A
(ja)
|
2015-06-29 |
2018-07-26 |
アイオーニス ファーマシューティカルズ, インコーポレーテッドIonis Pharmaceuticals,Inc. |
修飾crispr rna及び修飾単一crispr rnaならびにその使用
|
WO2017011276A1
(en)
|
2015-07-10 |
2017-01-19 |
Ionis Pharmaceuticals, Inc. |
Modulators of diacyglycerol acyltransferase 2 (dgat2)
|
US10494632B2
(en)
|
2015-07-10 |
2019-12-03 |
Alnylam Pharmaceuticals, Inc. |
Insulin-like growth factor binding protein, acid labile subunit (IGFALS) compositions and methods of use thereof
|
WO2017024111A1
(en)
|
2015-08-04 |
2017-02-09 |
The University Of Chicago |
Inhibitors of cacna1a/alpha1a subunit internal ribosomal entry site (ires) and methods of treating spinocerebellar ataxia type 6
|
JP6835826B2
(ja)
|
2015-08-24 |
2021-02-24 |
ロシュ イノベーション センター コペンハーゲン エーエス |
Lna−gプロセス
|
WO2017040078A1
(en)
|
2015-09-02 |
2017-03-09 |
Alnylam Pharmaceuticals, Inc. |
PROGRAMMED CELL DEATH 1 LIGAND 1 (PD-L1) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
KR20240027890A
(ko)
|
2015-09-14 |
2024-03-04 |
더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 |
지질양이온성 덴드리머 및 이의 용도
|
EP3353328A4
(en)
|
2015-09-24 |
2019-06-12 |
Ionis Pharmaceuticals, Inc. |
MODULATORS OF KRAS EXPRESSION
|
CA2999177A1
(en)
|
2015-09-24 |
2017-03-30 |
The Regents Of The University Of California |
Synthetic sphingolipid-like molecules, drugs, methods of their synthesis and methods of treatment
|
WO2017053781A1
(en)
|
2015-09-25 |
2017-03-30 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulating ataxin 3 expression
|
PE20181085A1
(es)
|
2015-10-08 |
2018-07-05 |
Ionis Pharmaceuticals Inc |
Composiciones y metodos para modular la expresion de angiotensinogeno
|
EP3359685A1
(en)
|
2015-10-09 |
2018-08-15 |
University Of Southampton |
Modulation of gene expression and screening for deregulated protein expression
|
WO2017068087A1
(en)
|
2015-10-22 |
2017-04-27 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotide detection method
|
EP3394258B1
(en)
|
2015-10-22 |
2021-09-22 |
Roche Innovation Center Copenhagen A/S |
In vitro toxicity screening assay
|
US11260073B2
(en)
|
2015-11-02 |
2022-03-01 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating C90RF72
|
US20190046555A1
(en)
|
2015-11-06 |
2019-02-14 |
Ionis Pharmaceuticals, Inc. |
Conjugated antisense compounds for use in therapy
|
US10557137B2
(en)
|
2015-11-06 |
2020-02-11 |
Ionis Pharmaceuticals, Inc. |
Modulating apolipoprotein (a) expression
|
ES2852998T3
(es)
|
2015-11-12 |
2021-09-14 |
Hoffmann La Roche |
Oligonucleótidos para inducir la expresión de UBE3A paterno
|
EP3389670A4
(en)
|
2015-12-04 |
2020-01-08 |
Ionis Pharmaceuticals, Inc. |
METHODS OF TREATING BREAST CANCER
|
US11096956B2
(en)
|
2015-12-14 |
2021-08-24 |
Stoke Therapeutics, Inc. |
Antisense oligomers and uses thereof
|
WO2017106377A1
(en)
|
2015-12-14 |
2017-06-22 |
Cold Spring Harbor Laboratory |
Antisense oligomers for treatment of autosomal dominant mental retardation-5 and dravet syndrome
|
US11761007B2
(en)
|
2015-12-18 |
2023-09-19 |
The Scripps Research Institute |
Production of unnatural nucleotides using a CRISPR/Cas9 system
|
CA3006599A1
(en)
|
2016-01-05 |
2017-07-13 |
Ionis Pharmaceuticals, Inc. |
Methods for reducing lrrk2 expression
|
US11136577B2
(en)
|
2016-03-09 |
2021-10-05 |
Ionis Pharmaceuticals, Inc. |
Methods and compositions for inhibiting PMP22 expression
|
ES2857702T3
(es)
|
2016-03-14 |
2021-09-29 |
Hoffmann La Roche |
Oligonucleótidos para la reducción de la expresión de PD-L1
|
WO2017161168A1
(en)
|
2016-03-16 |
2017-09-21 |
Ionis Pharmaceuticals, Inc. |
Modulation of dyrk1b expression
|
WO2017161172A1
(en)
|
2016-03-16 |
2017-09-21 |
Ionis Pharmaceuticals, Inc. |
Methods of modulating keap1
|
EP3443094B1
(en)
|
2016-04-13 |
2022-10-19 |
Ionis Pharmaceuticals, Inc. |
Methods for reducing c9orf72 expression
|
CN109153697A
(zh)
|
2016-04-14 |
2019-01-04 |
豪夫迈·罗氏有限公司 |
三苯甲基-单-GalNAc化合物及其用途
|
MA45295A
(fr)
|
2016-04-19 |
2019-02-27 |
Alnylam Pharmaceuticals Inc |
Composition d'arni de protéine de liaison de lipoprotéines haute densité (hdlbp/vigiline) et procédés pour les utiliser
|
CA3024129A1
(en)
|
2016-05-16 |
2017-11-23 |
The Board Of Regents Of The University Of Texas System |
Cationic sulfonamide amino lipids and amphiphilic zwitterionic amino lipids
|
KR102426487B1
(ko)
|
2016-06-06 |
2022-07-27 |
애로우헤드 파마슈티컬스 인코포레이티드 |
5'-시클로-포스포네이트 변형된 뉴클레오티드
|
EP3469083A1
(en)
|
2016-06-10 |
2019-04-17 |
Alnylam Pharmaceuticals, Inc. |
COMPLEMENT COMPONENT C5 iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH)
|
JP7012033B2
(ja)
|
2016-06-17 |
2022-02-10 |
エフ.ホフマン-ラ ロシュ アーゲー |
インビトロ腎毒性スクリーニングアッセイ
|
WO2017219017A1
(en)
|
2016-06-17 |
2017-12-21 |
Ionis Pharmaceuticals, Inc. |
Modulation of gys1 expression
|
MA45496A
(fr)
|
2016-06-17 |
2019-04-24 |
Hoffmann La Roche |
Molécules d'acide nucléique pour la réduction de l'arnm de padd5 ou pad7 pour le traitement d'une infection par l'hépatite b
|
EP3472348B1
(en)
|
2016-06-17 |
2022-06-29 |
F. Hoffmann-La Roche AG |
In vitro nephrotoxicity screening assay
|
ES2929047T3
(es)
|
2016-06-24 |
2022-11-24 |
Scripps Research Inst |
Transportador de nucleósido trifosfato novedoso y usos del mismo
|
SG10202005885VA
(en)
|
2016-07-01 |
2020-07-29 |
Hoffmann La Roche |
Antisense oligonucleotides for modulating htra1 expression
|
EP3507367A4
(en)
|
2016-07-05 |
2020-03-25 |
Aduro BioTech, Inc. |
CYCLIC DINUCLEOTID COMPOUNDS WITH INCLUDED NUCLEIC ACIDS AND USES THEREOF
|
LT3484524T
(lt)
|
2016-07-15 |
2022-12-27 |
Ionis Pharmaceuticals, Inc. |
Junginiai ir būdai, skirti smn2 moduliavimui
|
JOP20190065A1
(ar)
|
2016-09-29 |
2019-03-28 |
Ionis Pharmaceuticals Inc |
مركبات وطرق لتقليل التعبير عن tau
|
WO2018067900A1
(en)
|
2016-10-06 |
2018-04-12 |
Ionis Pharmaceuticals, Inc. |
Method of conjugating oligomeric compounds
|
JOP20190104A1
(ar)
|
2016-11-10 |
2019-05-07 |
Ionis Pharmaceuticals Inc |
مركبات وطرق لتقليل التعبير عن atxn3
|
WO2018087200A1
(en)
|
2016-11-11 |
2018-05-17 |
Roche Innovation Center Copenhagen A/S |
Therapeutic oligonucleotides capture and detection
|
TWI788312B
(zh)
|
2016-11-23 |
2023-01-01 |
美商阿尼拉製藥公司 |
絲胺酸蛋白酶抑制因子A1 iRNA組成物及其使用方法
|
EP3548620A4
(en)
|
2016-12-02 |
2020-07-22 |
Cold Spring Harbor Laboratory |
MODULATION OF THE EXPRESSION OF LNC05
|
SG10201913552UA
(en)
|
2016-12-16 |
2020-03-30 |
Alnylam Pharmaceuticals Inc |
Methods for treating or preventing ttr-associated diseases using transthyretin (ttr) irna compositions
|
US20190338286A1
(en)
|
2017-01-13 |
2019-11-07 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides for modulating rel expression
|
WO2018130583A1
(en)
|
2017-01-13 |
2018-07-19 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides for modulating nfkb1 expression
|
EP3568481A1
(en)
|
2017-01-13 |
2019-11-20 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides for modulating relb expression
|
US20190345495A1
(en)
|
2017-01-13 |
2019-11-14 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides for modulating nfkb2 expression
|
US20200216845A1
(en)
|
2017-01-13 |
2020-07-09 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides for modulating rela expression
|
US11180756B2
(en)
|
2017-03-09 |
2021-11-23 |
Ionis Pharmaceuticals |
Morpholino modified oligomeric compounds
|
JOP20190215A1
(ar)
|
2017-03-24 |
2019-09-19 |
Ionis Pharmaceuticals Inc |
مُعدّلات التعبير الوراثي عن pcsk9
|
CA3059446A1
(en)
|
2017-04-18 |
2018-10-25 |
Alnylam Pharmaceuticals, Inc. |
Methods for the treatment of subjects having a hepatitis b virus (hbv) infection
|
US20190055564A1
(en)
|
2017-06-01 |
2019-02-21 |
F. Hoffmann-La Roche Ag |
Antisense oligonucleotides for modulating htra1 expression
|
EP3599844A4
(en)
|
2017-06-07 |
2021-01-13 |
University of Massachusetts |
ANTI-ADAM33 OLIGONUCLEOTIDES AND RELATED PROCESSES
|
JP7325341B2
(ja)
|
2017-07-11 |
2023-08-14 |
シンソークス,インク. |
非天然ヌクレオチドの組み込み及びその方法
|
NZ761430A
(en)
|
2017-08-03 |
2024-03-22 |
Synthorx Inc |
Cytokine conjugates for the treatment of proliferative and infectious diseases
|
WO2019030313A2
(en)
|
2017-08-11 |
2019-02-14 |
Roche Innovation Center Copenhagen A/S |
OLIGONUCLEOTIDES FOR MODULATION OF UBE3C EXPRESSION
|
WO2019036613A1
(en)
|
2017-08-18 |
2019-02-21 |
Ionis Pharmaceuticals, Inc. |
MODULATION OF THE NOTCH SIGNALING PATHWAY FOR THE TREATMENT OF RESPIRATORY DISORDERS
|
WO2019038228A1
(en)
|
2017-08-22 |
2019-02-28 |
Roche Innovation Center Copenhagen A/S |
OLIGONUCLEOTIDES FOR MODULATION OF TOM1 EXPRESSION
|
CN111278991B
(zh)
|
2017-08-25 |
2022-04-01 |
斯托克制药公司 |
用于治疗病况和疾病的反义寡聚体
|
WO2019051173A1
(en)
|
2017-09-08 |
2019-03-14 |
Ionis Pharmaceuticals, Inc. |
MODULATORS OF SMAD7 EXPRESSION
|
CN111226114A
(zh)
|
2017-10-13 |
2020-06-02 |
罗氏创新中心哥本哈根有限公司 |
用部分立体限定的寡核苷酸子文库鉴定反义寡核苷酸改进的立体限定硫代磷酸酯寡核苷酸变体的方法
|
BR122020018622A2
(pt)
|
2017-10-16 |
2021-02-09 |
F. Hoffmann-La Roche Ag |
Molécula de ácido nucleico para redução de papd5 e papd7 de mrna para o tratamento de infecção hepatite b
|
WO2019089922A1
(en)
|
2017-11-01 |
2019-05-09 |
Alnylam Pharmaceuticals, Inc. |
Complement component c3 irna compositions and methods of use thereof
|
TWI809004B
(zh)
|
2017-11-09 |
2023-07-21 |
美商Ionis製藥公司 |
用於降低snca表現之化合物及方法
|
US20200385719A1
(en)
|
2017-11-16 |
2020-12-10 |
Alnylam Pharmaceuticals, Inc. |
Kisspeptin 1 (kiss1) irna compositions and methods of use thereof
|
WO2019100039A1
(en)
|
2017-11-20 |
2019-05-23 |
Alnylam Pharmaceuticals, Inc. |
Serum amyloid p component (apcs) irna compositions and methods of use thereof
|
US20200385714A1
(en)
|
2017-12-11 |
2020-12-10 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides for modulating fndc3b expression
|
WO2019115417A2
(en)
|
2017-12-12 |
2019-06-20 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides for modulating rb1 expression
|
EP3724206B1
(en)
|
2017-12-14 |
2023-06-28 |
Ionis Pharmaceuticals, Inc. |
Conjugated antisense compounds and their use
|
US20200308588A1
(en)
|
2017-12-18 |
2020-10-01 |
Alnylam Pharmaceuticals, Inc. |
High mobility group box-1 (hmgb1) irna compositions and methods of use thereof
|
US20200378970A1
(en)
|
2017-12-21 |
2020-12-03 |
Hoffmann-La Roche Inc. |
Companion diagnostic for htra1 rna antagonists
|
WO2019126641A2
(en)
|
2017-12-21 |
2019-06-27 |
Ionis Pharmaceuticals, Inc. |
Modulation of frataxin expression
|
MX2020005754A
(es)
|
2017-12-22 |
2020-08-20 |
Roche Innovation Ct Copenhagen As |
Oligonucleotidos gapmeros que comprenden un enlace internucleosido fosforoditioato.
|
WO2019122279A1
(en)
|
2017-12-22 |
2019-06-27 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides comprising a phosphorodithioate internucleoside linkage
|
KR20200104302A
(ko)
|
2017-12-22 |
2020-09-03 |
로슈 이노베이션 센터 코펜하겐 에이/에스 |
신규 티오포스포르아미다이트
|
JP2021511022A
(ja)
|
2018-01-10 |
2021-05-06 |
ロシュ イノベーション センター コペンハーゲン エーエス |
Pias4発現を調節するためのオリゴヌクレオチド
|
JP2021510295A
(ja)
|
2018-01-12 |
2021-04-22 |
ロシュ イノベーション センター コペンハーゲン エーエス |
Gsk3b発現を調節するためのオリゴヌクレオチド
|
SG11202006142PA
(en)
|
2018-01-12 |
2020-07-29 |
Roche Innovation Ct Copenhagen As |
Alpha-synuclein antisense oligonucleotides and uses thereof
|
US11447775B2
(en)
|
2018-01-12 |
2022-09-20 |
Bristol-Myers Squibb Company |
Antisense oligonucleotides targeting alpha-synuclein and uses thereof
|
CA3087966A1
(en)
|
2018-01-12 |
2019-07-18 |
Bristol-Myers Squibb Company |
Antisense oligonucleotides targeting alpha-synuclein and uses thereof
|
US20200392510A1
(en)
|
2018-01-15 |
2020-12-17 |
Ionis Pharmaceuticals, Inc. |
Modulators of dnm2 expression
|
US20210095276A1
(en)
|
2018-01-17 |
2021-04-01 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides for modulating erc1 expression
|
US20210095277A1
(en)
|
2018-01-18 |
2021-04-01 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting srebp1
|
WO2019145386A1
(en)
|
2018-01-26 |
2019-08-01 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides for modulating csnk1d expression
|
CR20200346A
(es)
|
2018-02-09 |
2020-10-19 |
Genentech Inc |
Oligonucleótidos para modular la expresión de tmem106b
|
US11332733B2
(en)
|
2018-02-12 |
2022-05-17 |
lonis Pharmaceuticals, Inc. |
Modified compounds and uses thereof
|
SG11202007652UA
(en)
|
2018-02-21 |
2020-09-29 |
Bristol Myers Squibb Co |
Camk2d antisense oligonucleotides and uses thereof
|
JP2021514974A
(ja)
|
2018-02-26 |
2021-06-17 |
シンソークス, インコーポレイテッド |
Il−15コンジュゲートおよびその使用
|
EP3759127A4
(en)
|
2018-03-02 |
2022-03-30 |
Ionis Pharmaceuticals, Inc. |
COMPOUNDS AND METHODS FOR MODULATING AMYLOID BETA PRECURSOR PROTEIN
|
JP7239597B2
(ja)
|
2018-03-02 |
2023-03-14 |
アイオーニス ファーマシューティカルズ, インコーポレーテッド |
Irf4発現の調節因子
|
EP3768694A4
(en)
|
2018-03-22 |
2021-12-29 |
Ionis Pharmaceuticals, Inc. |
Methods for modulating fmr1 expression
|
MX2020010383A
(es)
|
2018-04-05 |
2020-12-10 |
Hoffmann La Roche |
Uso de inhibidores de fubp1 para el tratamiento de infeccion de virus de hepatitis b.
|
JP7275164B2
(ja)
|
2018-04-11 |
2023-05-17 |
アイオーニス ファーマシューティカルズ, インコーポレーテッド |
Ezh2発現の調節因子
|
WO2019200273A1
(en)
|
2018-04-13 |
2019-10-17 |
Bristol-Myers Squibb Company |
Novel phosphorous (v)-based reagents, processes for the preparation thereof, and their use in making stereo-defined organophoshorous (v) compounds
|
EP3790990A1
(en)
|
2018-05-07 |
2021-03-17 |
Roche Innovation Center Copenhagen A/S |
Quality control of lna oligonucleotide therapeutics using massively parallel sequencing
|
US20210371860A1
(en)
|
2018-05-08 |
2021-12-02 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides for modulating myh7 expression
|
KR20210008497A
(ko)
|
2018-05-09 |
2021-01-22 |
아이오니스 파마수티컬즈, 인코포레이티드 |
Atxn3 발현 감소용 화합물 및 방법
|
BR112020020957B1
(pt)
|
2018-05-09 |
2022-05-10 |
Ionis Pharmaceuticals, Inc |
Compostos oligoméricos, população e composição farmacêutica dos mesmos e seus usos
|
TW202016304A
(zh)
|
2018-05-14 |
2020-05-01 |
美商阿尼拉製藥公司 |
血管收縮素原(AGT)iRNA組成物及其使用方法
|
EP3793685A1
(en)
|
2018-05-18 |
2021-03-24 |
F. Hoffmann-La Roche AG |
Pharmaceutical compositions for treatment of microrna related diseases
|
WO2019224172A1
(en)
|
2018-05-25 |
2019-11-28 |
Roche Innovation Center Copenhagen A/S |
Novel process for making allofuranose from glucofuranose
|
CN112912500A
(zh)
|
2018-06-05 |
2021-06-04 |
豪夫迈·罗氏有限公司 |
用于调节atxn2表达的寡核苷酸
|
JP2021526823A
(ja)
|
2018-06-14 |
2021-10-11 |
アイオーニス ファーマシューティカルズ, インコーポレーテッドIonis Pharmaceuticals,Inc. |
Stmn2発現を増加させるための化合物及び方法
|
JP7315594B2
(ja)
|
2018-06-27 |
2023-07-26 |
アイオーニス ファーマシューティカルズ, インコーポレーテッド |
Lrrk2発現を低減するための化合物及び方法
|
WO2020007702A1
(en)
|
2018-07-02 |
2020-01-09 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting bcl2l11
|
WO2020007772A1
(en)
|
2018-07-02 |
2020-01-09 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting gbp-1
|
WO2020007700A1
(en)
|
2018-07-02 |
2020-01-09 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting spi1
|
EP3818159A1
(en)
|
2018-07-03 |
2021-05-12 |
F. Hoffmann-La Roche AG |
Oligonucleotides for modulating tau expression
|
WO2020007889A1
(en)
|
2018-07-05 |
2020-01-09 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting stat1
|
WO2020007826A1
(en)
|
2018-07-05 |
2020-01-09 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting mbtps1
|
WO2020011743A1
(en)
|
2018-07-09 |
2020-01-16 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting mafb
|
WO2020011653A1
(en)
|
2018-07-09 |
2020-01-16 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting kynu
|
WO2020011869A2
(en)
|
2018-07-11 |
2020-01-16 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting tlr2
|
WO2020011745A2
(en)
|
2018-07-11 |
2020-01-16 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting cers6
|
WO2020011744A2
(en)
|
2018-07-11 |
2020-01-16 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting cers5
|
CR20210015A
(es)
|
2018-07-13 |
2021-03-22 |
Hoffmann La Roche |
Oligonucleótidos para modular la expresión de rtel 1
|
EP3826645A4
(en)
|
2018-07-25 |
2023-05-17 |
Ionis Pharmaceuticals, Inc. |
COMPOUNDS AND METHODS FOR REDUCING ATXN2 EXPRESSION
|
BR112021001756A2
(pt)
|
2018-07-31 |
2021-05-11 |
Roche Innovation Center Copenhagen A/S |
oligonucleotídeos, oligonucleotídeo gapmer, sal farmaceuticamente aceitável, conjugado, composição farmacêutica, usos de um oligonucleotídeo, método para o tratamento ou profilaxia de uma doença, processo para a fabricação de um oligonucleotídeo e invenção
|
CA3098267A1
(en)
|
2018-07-31 |
2020-02-06 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides comprising a phosphorotrithioate internucleoside linkage
|
JP2021533767A
(ja)
|
2018-08-13 |
2021-12-09 |
アルナイラム ファーマシューティカルズ, インコーポレイテッドAlnylam Pharmaceuticals, Inc. |
B型肝炎ウイルス(HBV)dsRNA物質組成物およびその使用方法
|
BR112021002779A2
(pt)
|
2018-08-15 |
2021-05-04 |
Illumina, Inc. |
composições e métodos para melhorar o enriquecimento de bibliotecas
|
CN113329739A
(zh)
|
2018-08-20 |
2021-08-31 |
罗贡股份有限公司 |
用于治疗scn1a脑病的靶向scn2a的反义寡核苷酸
|
WO2020038971A1
(en)
|
2018-08-23 |
2020-02-27 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting vcan
|
WO2020038976A1
(en)
|
2018-08-23 |
2020-02-27 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting usp8
|
WO2020038973A1
(en)
|
2018-08-23 |
2020-02-27 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting sptlc1
|
CN112585280A
(zh)
|
2018-08-23 |
2021-03-30 |
罗氏创新中心哥本哈根有限公司 |
微小rna-134生物标志物
|
WO2020043750A1
(en)
|
2018-08-28 |
2020-03-05 |
Roche Innovation Center Copenhagen A/S |
Neoantigen engineering using splice modulating compounds
|
EP3620519A1
(en)
|
2018-09-04 |
2020-03-11 |
F. Hoffmann-La Roche AG |
Use of isolated milk extracellular vesicles for delivering oligonucleotides orally
|
EP3620520A1
(en)
|
2018-09-10 |
2020-03-11 |
Universidad del Pais Vasco |
Novel target to treat a metabolic disease in an individual
|
CN112424355A
(zh)
|
2018-09-18 |
2021-02-26 |
阿尔尼拉姆医药品有限公司 |
己酮糖激酶(KHK)iRNA组合物及其使用方法
|
TW202023573A
(zh)
|
2018-09-19 |
2020-07-01 |
美商Ionis製藥公司 |
Pnpla3表現之調節劑
|
US10913951B2
(en)
|
2018-10-31 |
2021-02-09 |
University of Pittsburgh—of the Commonwealth System of Higher Education |
Silencing of HNF4A-P2 isoforms with siRNA to improve hepatocyte function in liver failure
|
WO2020089260A1
(en)
|
2018-11-01 |
2020-05-07 |
F. Hoffmann-La Roche Ag |
Antisense oligonucleotides targeting tia1
|
TW202028222A
(zh)
|
2018-11-14 |
2020-08-01 |
美商Ionis製藥公司 |
Foxp3表現之調節劑
|
BR112021008967A2
(pt)
|
2018-11-15 |
2021-08-17 |
Ionis Pharmaceuticals, Inc. |
moduladores da expressão de irf5
|
WO2020104492A1
(en)
|
2018-11-22 |
2020-05-28 |
Roche Innovation Center Copenhagen A/S |
Pyridinium salts as activators in the synthesis of stereodefined oligonucleotides
|
WO2020109344A1
(en)
|
2018-11-29 |
2020-06-04 |
F. Hoffmann-La Roche Ag |
Occular administration device for antisense oligonucleotides
|
WO2020109343A1
(en)
|
2018-11-29 |
2020-06-04 |
F. Hoffmann-La Roche Ag |
Combination therapy for treatment of macular degeneration
|
CN113631709A
(zh)
|
2018-12-20 |
2021-11-09 |
普拉克西斯精密药物股份有限公司 |
用于治疗kcnt1相关病症的组合物和方法
|
WO2020136125A2
(en)
|
2018-12-21 |
2020-07-02 |
Boehringer Ingelheim International Gmbh |
Antisense oligonucleotides targeting card9
|
SG11202107669WA
(en)
|
2019-01-16 |
2021-08-30 |
Genzyme Corp |
Serpinc1 irna compositions and methods of use thereof
|
JP2022518500A
(ja)
|
2019-01-25 |
2022-03-15 |
エフ.ホフマン-ラ ロシュ アーゲー |
経口薬物送達のための脂質小胞
|
MX2021008918A
(es)
|
2019-01-31 |
2021-08-24 |
Ionis Pharmaceuticals Inc |
Moduladores de expresion yap1.
|
BR112021014415A2
(pt)
|
2019-02-06 |
2021-09-21 |
Synthorx, Inc. |
Conjugados de il-2 e métodos de uso dos mesmos
|
CA3130431A1
(en)
|
2019-02-20 |
2020-08-27 |
Roche Innovation Center Copenhagen A/S |
Phosphonoacetate gapmer oligonucleotides
|
KR20210132681A
(ko)
|
2019-02-20 |
2021-11-04 |
로슈 이노베이션 센터 코펜하겐 에이/에스 |
신규 포스포라미디트
|
CN113474633A
(zh)
|
2019-02-26 |
2021-10-01 |
罗氏创新中心哥本哈根有限公司 |
寡核苷酸配制方法
|
EP3931328A4
(en)
|
2019-02-27 |
2023-09-13 |
Ionis Pharmaceuticals, Inc. |
MODULATORS OF MALAT1 EXPRESSION
|
SG11202109587TA
(en)
|
2019-03-21 |
2021-10-28 |
Codiak Biosciences Inc |
Extracellular vesicle conjugates and uses thereof
|
CA3198063A1
(en)
|
2019-03-29 |
2020-10-08 |
Mitsubishi Tanabe Pharma Corporation |
Compound, method and pharmaceutical composition for modulating expression of dux4
|
AU2020253821A1
(en)
|
2019-03-29 |
2021-10-28 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating UBE3A-ATS
|
BR112021019182A2
(pt)
|
2019-04-03 |
2022-05-31 |
Bristol Myers Squibb Co |
Oligonucleotídeos angptl2 antissenso e seus usos
|
US11286485B2
(en)
|
2019-04-04 |
2022-03-29 |
Hoffmann-La Roche Inc. |
Oligonucleotides for modulating ATXN2 expression
|
EP3947677A1
(en)
|
2019-04-04 |
2022-02-09 |
F. Hoffmann-La Roche AG |
Oligonucleotides for modulating atxn2 expression
|
WO2020212301A1
(en)
|
2019-04-16 |
2020-10-22 |
Roche Innovation Center Copenhagen A/S |
Novel process for preparing nucleotide p(v) monomers
|
JP2022530537A
(ja)
|
2019-04-30 |
2022-06-29 |
ロシュ イノベーション センター コペンハーゲン エーエス |
レニウムキレート化mag3オリゴヌクレオチドを調製するための新規の方法
|
US20220177880A1
(en)
|
2019-05-03 |
2022-06-09 |
Dicerna Pharmaceuticals, Inc. |
Double-stranded nucleic acid inhibitor molecules with shortened sense strands
|
US20220243203A1
(en)
|
2019-05-28 |
2022-08-04 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for reducing fus expression
|
JP7155302B2
(ja)
|
2019-06-06 |
2022-10-18 |
エフ.ホフマン-ラ ロシュ アーゲー |
Atxn3を標的とするアンチセンスオリゴヌクレオチド
|
TW202113078A
(zh)
|
2019-06-14 |
2021-04-01 |
美商史基普研究協會 |
於半合成生物體中複製、轉錄及轉譯之試劑及方法
|
EP3956450A4
(en)
|
2019-07-26 |
2022-11-16 |
Ionis Pharmaceuticals, Inc. |
COMPOUNDS AND METHODS FOR MODULATION OF GFAP
|
WO2021022108A2
(en)
|
2019-08-01 |
2021-02-04 |
Alnylam Pharmaceuticals, Inc. |
CARBOXYPEPTIDASE B2 (CPB2) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
WO2021022109A1
(en)
|
2019-08-01 |
2021-02-04 |
Alnylam Pharmaceuticals, Inc. |
SERPIN FAMILY F MEMBER 2 (SERPINF2) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
WO2021030522A1
(en)
|
2019-08-13 |
2021-02-18 |
Alnylam Pharmaceuticals, Inc. |
SMALL RIBOSOMAL PROTEIN SUBUNIT 25 (RPS25) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF
|
CA3147366A1
(en)
|
2019-08-14 |
2021-02-18 |
Adam T. BOUTIN |
Extracellular vesicles with stat3-antisense oligonucleotides
|
MX2022001770A
(es)
|
2019-08-14 |
2022-05-20 |
Codiak Biosciences Inc |
Vesícula extracelular unida a moléculas y usos de esta.
|
JP2022544935A
(ja)
|
2019-08-14 |
2022-10-24 |
コディアック バイオサイエンシーズ, インコーポレイテッド |
細胞外小胞-nlrp3アンタゴニスト
|
MX2022001767A
(es)
|
2019-08-14 |
2022-06-09 |
Codiak Biosciences Inc |
Construcciones de vesículas-oligonucleótidos antisentido (aso) extracelulares que se dirigen a transductor de señal y activador de la transcripción 6 (stat6).
|
EP4013872A1
(en)
|
2019-08-14 |
2022-06-22 |
Codiak BioSciences, Inc. |
Extracellular vesicles with antisense oligonucleotides targeting kras
|
WO2021030780A1
(en)
|
2019-08-14 |
2021-02-18 |
Codiak Biosciences, Inc. |
Extracellular vesicle-aso constructs targeting cebp/beta
|
CN114555621A
(zh)
|
2019-08-15 |
2022-05-27 |
Ionis制药公司 |
键修饰的寡聚化合物及其用途
|
MX2022001776A
(es)
|
2019-08-15 |
2022-03-17 |
Synthorx Inc |
Terapias de combinacion de inmuno oncologia con conjugados de il-2.
|
MX2022002053A
(es)
|
2019-08-23 |
2022-03-17 |
Synthorx Inc |
Conjugados de il-15 y sus usos.
|
US20210070827A1
(en)
|
2019-09-10 |
2021-03-11 |
Synthorx, Inc. |
Il-2 conjugates and methods of use to treat autoimmune diseases
|
US20230241089A1
(en)
|
2019-09-25 |
2023-08-03 |
Codiak Biosciences, Inc. |
Sting agonist comprising exosomes for treating neuroimmunological disorders
|
EP4045062A1
(en)
|
2019-10-14 |
2022-08-24 |
Astrazeneca AB |
Modulators of pnpla3 expression
|
EP4045652A1
(en)
|
2019-10-18 |
2022-08-24 |
Alnylam Pharmaceuticals, Inc. |
Solute carrier family member irna compositions and methods of use thereof
|
CN115176004A
(zh)
|
2019-10-22 |
2022-10-11 |
阿尔尼拉姆医药品有限公司 |
补体成分C3 iRNA组合物及其使用方法
|
AR120341A1
(es)
|
2019-11-01 |
2022-02-09 |
Alnylam Pharmaceuticals Inc |
COMPOSICIONES DE AGENTES DE ARNi CONTRA LA HUNTINGTINA (HTT) Y SUS MÉTODOS DE USO
|
TW202131952A
(zh)
|
2019-11-04 |
2021-09-01 |
美商欣爍克斯公司 |
介白素10接合物及其用途
|
BR112022009216A2
(pt)
|
2019-11-13 |
2022-08-02 |
Alnylam Pharmaceuticals Inc |
Métodos e composições para tratar um distúrbio associado a angiotensinogênio (agt)
|
US20230056569A1
(en)
|
2019-11-22 |
2023-02-23 |
Alnylam Pharmaceuticals, Inc. |
Ataxin3 (atxn3) rnai agent compositions and methods of use thereof
|
BR112022011417A2
(pt)
|
2019-12-13 |
2022-08-30 |
Alnylam Pharmaceuticals Inc |
Composições do agente de irna da fase de leitura aberta 72 do cromossomo humano 9 (c9orf72) e métodos de uso das mesmas
|
TW202138559A
(zh)
|
2019-12-16 |
2021-10-16 |
美商阿尼拉製藥公司 |
含類PATATIN磷脂酶結構域3(PNPLA3)iRNA組成物及其使用方法
|
JP2023506550A
(ja)
|
2019-12-19 |
2023-02-16 |
エフ. ホフマン-ラ ロシュ エージー. |
B型肝炎ウイルス感染症を処置するためのsbds阻害剤の使用
|
EP4077671A1
(en)
|
2019-12-19 |
2022-10-26 |
F. Hoffmann-La Roche AG |
Use of saraf inhibitors for treating hepatitis b virus infection
|
WO2021122921A1
(en)
|
2019-12-19 |
2021-06-24 |
F. Hoffmann-La Roche Ag |
Use of cops3 inhibitors for treating hepatitis b virus infection
|
JP2023506540A
(ja)
|
2019-12-19 |
2023-02-16 |
エフ. ホフマン-ラ ロシュ エージー. |
B型肝炎ウイルス感染を処置するためのscamp3阻害剤の使用
|
CN114901821A
(zh)
|
2019-12-19 |
2022-08-12 |
豪夫迈·罗氏有限公司 |
Sept9抑制剂用于治疗乙型肝炎病毒感染的用途
|
EP4077672A1
(en)
|
2019-12-20 |
2022-10-26 |
F. Hoffmann-La Roche AG |
Enhanced oligonucleotides for inhibiting scn9a expression
|
TW202137987A
(zh)
|
2019-12-24 |
2021-10-16 |
瑞士商赫孚孟拉羅股份公司 |
用於治療hbv之靶向hbv的治療性寡核苷酸及tlr7促效劑之醫藥組合
|
AU2020415322A1
(en)
|
2019-12-24 |
2022-06-16 |
F. Hoffmann-La Roche Ag |
Pharmaceutical combination of antiviral agents targeting HBV and/or an immune modulator for treatment of HBV
|
WO2021158810A1
(en)
|
2020-02-05 |
2021-08-12 |
Bristol-Myers Squibb Company |
Oligonucleotides for splice modulation of camk2d
|
KR20220140593A
(ko)
|
2020-02-10 |
2022-10-18 |
알닐람 파마슈티칼스 인코포레이티드 |
Vegf-a 발현을 사일런싱하기 위한 조성물 및 방법
|
US20230124641A1
(en)
*
|
2020-02-18 |
2023-04-20 |
Osaka University |
Cross-linked nucleoside and nucleotide using same
|
IL295496A
(en)
|
2020-02-18 |
2022-10-01 |
Alnylam Pharmaceuticals Inc |
Apolipoprotein c3 (apoc3) irna preparations and methods of using them
|
EP4110916A1
(en)
|
2020-02-28 |
2023-01-04 |
F. Hoffmann-La Roche AG |
Oligonucleotides for modulating cd73 exon 7 splicing
|
US20220064638A1
(en)
|
2020-02-28 |
2022-03-03 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating smn2
|
US20230159924A1
(en)
|
2020-03-02 |
2023-05-25 |
Mitsubishi Tanabe Pharma Corporation |
Prevention or treatment of aneurysms using mir-33b inhibitor
|
WO2021178607A1
(en)
|
2020-03-05 |
2021-09-10 |
Alnylam Pharmaceuticals, Inc. |
Complement component c3 irna compositions and methods of use thereof for treating or preventing complement component c3-associated diseases
|
JP2023516748A
(ja)
|
2020-03-06 |
2023-04-20 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
トランスサイレチン(ttr)の発現を阻害するための組成物および方法
|
AU2021232014A1
(en)
|
2020-03-06 |
2022-10-06 |
Alnylam Pharmaceuticals, Inc. |
Ketohexokinase (KHK) IRNA compositions and methods of use thereof
|
WO2021184020A1
(en)
|
2020-03-13 |
2021-09-16 |
Codiak Biosciences, Inc. |
Methods of treating neuroinflammation
|
WO2021184021A1
(en)
|
2020-03-13 |
2021-09-16 |
Codiak Biosciences, Inc. |
Extracellular vesicle-aso constructs targeting pmp22
|
WO2021188611A1
(en)
|
2020-03-18 |
2021-09-23 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for treating subjects having a heterozygous alanine-glyoxylate aminotransferase gene (agxt) variant
|
JP2023519274A
(ja)
|
2020-03-26 |
2023-05-10 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
コロナウイルスiRNA組成物およびその使用方法
|
US20230295622A1
(en)
|
2020-04-06 |
2023-09-21 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for silencing myoc expression
|
JP2023521094A
(ja)
|
2020-04-07 |
2023-05-23 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
Scn9a発現をサイレンシングするための組成物および方法
|
EP4133076A1
(en)
|
2020-04-07 |
2023-02-15 |
Alnylam Pharmaceuticals, Inc. |
Angiotensin-converting enzyme 2 (ace2) irna compositions and methods of use thereof
|
WO2021206922A1
(en)
|
2020-04-07 |
2021-10-14 |
Alnylam Pharmaceuticals, Inc. |
Transmembrane serine protease 2 (tmprss2) irna compositions and methods of use thereof
|
JP2023523993A
(ja)
|
2020-04-27 |
2023-06-08 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
アポリポタンパク質E(ApoE)iRNA剤組成物およびその使用方法
|
CN116096381A
(zh)
|
2020-04-30 |
2023-05-09 |
阿尔尼拉姆医药品有限公司 |
补体因子B(CFB)iRNA组合物及其使用方法
|
IL297435A
(en)
|
2020-05-01 |
2022-12-01 |
Ionis Pharmaceuticals Inc |
Compounds and methods for modulating atxn1
|
JP2023527693A
(ja)
|
2020-05-11 |
2023-06-30 |
ジェネンテック, インコーポレイテッド |
神経疾患を治療するための補体成分c1r阻害剤、並びに関連する組成物、システム、及びそれを使用する方法
|
CA3173647A1
(en)
|
2020-05-11 |
2021-11-18 |
Isabel AZNAREZ |
Opa1 antisense oligomers for treatment of conditions and diseases
|
WO2021231211A1
(en)
|
2020-05-11 |
2021-11-18 |
Genentech, Inc. |
Complement component c1s inhibitors for treating a neurological disease, and related compositions, systems and methods of using same
|
WO2021231204A1
(en)
|
2020-05-11 |
2021-11-18 |
Genentech, Inc. |
Complement component 4 inhibitors for treating neurological diseases, and related compositons, systems and methods of using same
|
US20230227824A1
(en)
|
2020-05-12 |
2023-07-20 |
Mitsubishi Tanabe Pharma Corporation |
Compound, method and pharmaceutical composition for regulating expression of ataxin 3
|
WO2021229036A1
(en)
|
2020-05-13 |
2021-11-18 |
F. Hoffmann-La Roche Ag |
Oligonucleotide agonists targeting progranulin
|
EP4150089A1
(en)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of retinoschisin 1 (rs1)
|
EP4150076A1
(en)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of methyl-cpg binding protein 2 (mecp2)
|
EP4150078A1
(en)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of argininosuccinate lyase (asl)
|
WO2021231679A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of gap junction protein beta 2 (gjb2)
|
WO2021231692A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of otoferlin (otof)
|
EP4150086A1
(en)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of leucine rich repeat kinase 2 (lrrk2)
|
WO2021231675A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of argininosuccinate synthetase (ass1)
|
EP4150077A1
(en)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of transmembrane channel-like protein 1 (tmc1)
|
CN115884777A
(zh)
|
2020-05-22 |
2023-03-31 |
豪夫迈·罗氏有限公司 |
用于card9的剪接调节的寡核苷酸
|
US11408000B2
(en)
|
2020-06-03 |
2022-08-09 |
Triplet Therapeutics, Inc. |
Oligonucleotides for the treatment of nucleotide repeat expansion disorders associated with MSH3 activity
|
JP2023529457A
(ja)
|
2020-06-09 |
2023-07-10 |
ロシュ イノベーション センター コペンハーゲン エーエス |
治療用ポリヌクレオチドに使用するためのグアノシン類似体
|
EP4162050A1
(en)
|
2020-06-09 |
2023-04-12 |
Alnylam Pharmaceuticals, Inc. |
Rnai compositions and methods of use thereof for delivery by inhalation
|
CA3184289A1
(en)
|
2020-06-18 |
2021-12-23 |
Alnylam Pharmaceuticals, Inc. |
Xanthine dehydrogenase (xdh) irna compositions and methods of use thereof
|
KR20230027235A
(ko)
|
2020-06-25 |
2023-02-27 |
신톡스, 인크. |
Il-2 콘쥬게이트 및 항-egfr 항체를 사용한 면역 종양학 병용 요법
|
AR122731A1
(es)
|
2020-06-26 |
2022-10-05 |
Hoffmann La Roche |
Oligonucleótidos mejorados para modular la expresión de fubp1
|
US11732263B2
(en)
|
2020-06-29 |
2023-08-22 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating PLP1
|
EP4183416A1
(en)
|
2020-07-17 |
2023-05-24 |
Mitsubishi Tanabe Pharma Corporation |
Agent for preventing or treating muscular disease
|
WO2022018155A1
(en)
|
2020-07-23 |
2022-01-27 |
F. Hoffmann-La Roche Ag |
Lna oligonucleotides for splice modulation of stmn2
|
EP4185696A1
(en)
|
2020-07-23 |
2023-05-31 |
F. Hoffmann-La Roche AG |
Oligonucleotides targeting rna binding protein sites
|
EP4200419A2
(en)
|
2020-08-21 |
2023-06-28 |
F. Hoffmann-La Roche AG |
Use of a1cf inhibitors for treating hepatitis b virus infection
|
TW202227102A
(zh)
|
2020-09-22 |
2022-07-16 |
瑞典商阿斯特捷利康公司 |
治療脂肪肝病之方法
|
EP4217489A1
(en)
|
2020-09-24 |
2023-08-02 |
Alnylam Pharmaceuticals, Inc. |
Dipeptidyl peptidase 4 (dpp4) irna compositions and methods of use thereof
|
WO2022076291A1
(en)
|
2020-10-05 |
2022-04-14 |
Alnylam Pharmaceuticals, Inc. |
G protein-coupled receptor 75 (gpr75) irna compositions and methods of use thereof
|
US20230364127A1
(en)
|
2020-10-06 |
2023-11-16 |
Codiak Biosciences, Inc. |
Extracellular vesicle-aso constructs targeting stat6
|
MX2023004029A
(es)
|
2020-10-09 |
2023-04-27 |
Synthorx Inc |
Terapia de combinacion de inmunoncologia con conjugados de il-2 y pembrolizumab.
|
AU2021356610A1
(en)
|
2020-10-09 |
2023-06-15 |
Synthorx, Inc. |
Immuno oncology therapies with il-2 conjugates
|
EP4232582A1
(en)
|
2020-10-23 |
2023-08-30 |
Alnylam Pharmaceuticals, Inc. |
Mucin 5b (muc5b) irna compositions and methods of use thereof
|
IL302709A
(en)
|
2020-11-13 |
2023-07-01 |
Alnylam Pharmaceuticals Inc |
Coagulation factor iRNA compositions (F5) and methods of using them
|
AU2021381363A1
(en)
|
2020-11-18 |
2023-06-15 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating angiotensinogen expression
|
WO2022107025A1
(en)
|
2020-11-18 |
2022-05-27 |
Lemba Bv |
Umlilo antisense transcription inhibitors
|
WO2022106695A1
(en)
|
2020-11-23 |
2022-05-27 |
Alpha Anomeric Sas |
Nucleic acid duplexes
|
AR124229A1
(es)
|
2020-12-03 |
2023-03-01 |
Hoffmann La Roche |
Oligonucleótidos antisentido que actúan sobre atxn3
|
TW202237843A
(zh)
|
2020-12-03 |
2022-10-01 |
瑞士商赫孚孟拉羅股份公司 |
靶向atxn3之反義寡核苷酸
|
EP4259795A1
(en)
|
2020-12-08 |
2023-10-18 |
Alnylam Pharmaceuticals, Inc. |
Coagulation factor x (f10) irna compositions and methods of use thereof
|
JP2023553069A
(ja)
|
2020-12-08 |
2023-12-20 |
エフ. ホフマン-ラ ロシュ アーゲー |
ホスホロジチオエートオリゴヌクレオチドの新規合成
|
GB2603454A
(en)
|
2020-12-09 |
2022-08-10 |
Ucl Business Ltd |
Novel therapeutics for the treatment of neurodegenerative disorders
|
JP2023553710A
(ja)
|
2020-12-18 |
2023-12-25 |
エフ. ホフマン-ラ ロシュ アーゲー |
プログラニュリンを標的とするためのアンチセンスオリゴヌクレオチド
|
EP4267734A1
(en)
|
2020-12-22 |
2023-11-01 |
F. Hoffmann-La Roche AG |
Oligonucleotides targeting xbp1
|
WO2022150260A1
(en)
|
2021-01-05 |
2022-07-14 |
Alnylam Pharmaceuticals, Inc. |
COMPLEMENT COMPONENT 9 (C9) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
TW202246500A
(zh)
|
2021-02-02 |
2022-12-01 |
瑞士商赫孚孟拉羅股份公司 |
用於抑制 rtel1 表現之增強型寡核苷酸
|
WO2022174101A1
(en)
|
2021-02-12 |
2022-08-18 |
Synthorx, Inc. |
Skin cancer combination therapy with il-2 conjugates and cemiplimab
|
WO2022174000A2
(en)
|
2021-02-12 |
2022-08-18 |
Alnylam Pharmaceuticals, Inc. |
Superoxide dismutase 1 (sod1) irna compositions and methods of use thereof for treating or preventing superoxide dismutase 1- (sod1-) associated neurodegenerative diseases
|
WO2022174102A1
(en)
|
2021-02-12 |
2022-08-18 |
Synthorx, Inc. |
Lung cancer combination therapy with il-2 conjugates and an anti-pd-1 antibody or antigen-binding fragment thereof
|
IL305176A
(en)
|
2021-02-17 |
2023-10-01 |
Lonza Sales Ag |
An extracellular vesicle is linked to a biologically active molecule via an optimal linker and an anchored moiety
|
KR20230147125A
(ko)
|
2021-02-17 |
2023-10-20 |
론자 세일즈 아게 |
세포외 소포-nlrp3 길항제
|
WO2022182864A1
(en)
|
2021-02-25 |
2022-09-01 |
Alnylam Pharmaceuticals, Inc. |
Prion protein (prnp) irna compositions and methods and methods of use thereof
|
AU2022226098A1
(en)
|
2021-02-26 |
2023-08-24 |
Alnylam Pharmaceuticals, Inc. |
KETOHEXOKINASE (KHK) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
IL305418A
(en)
|
2021-03-04 |
2023-10-01 |
Alnylam Pharmaceuticals Inc |
Angiopoietin-like 3 (ANGPTL3) IRNA compositions and methods of using them
|
WO2022192519A1
(en)
|
2021-03-12 |
2022-09-15 |
Alnylam Pharmaceuticals, Inc. |
Glycogen synthase kinase 3 alpha (gsk3a) irna compositions and methods of use thereof
|
AR125230A1
(es)
|
2021-03-29 |
2023-06-28 |
Alnylam Pharmaceuticals Inc |
COMPOSICIONES DE AGENTES DE ARNi CONTRA HUNTINGTINA (HTT) Y SUS MÉTODOS DE USO
|
CN117120041A
(zh)
|
2021-04-01 |
2023-11-24 |
隆萨销售股份有限公司 |
胞外囊泡组合物
|
EP4314293A1
(en)
|
2021-04-01 |
2024-02-07 |
Alnylam Pharmaceuticals, Inc. |
Proline dehydrogenase 2 (prodh2) irna compositions and methods of use thereof
|
EP4330392A1
(en)
|
2021-04-26 |
2024-03-06 |
Alnylam Pharmaceuticals, Inc. |
Transmembrane protease, serine 6 (tmprss6) irna compositions and methods of use thereof
|
WO2022232343A1
(en)
|
2021-04-29 |
2022-11-03 |
Alnylam Pharmaceuticals, Inc. |
Signal transducer and activator of transcription factor 6 (stat6) irna compositions and methods of use thereof
|
WO2022230987A1
(ja)
|
2021-04-30 |
2022-11-03 |
田辺三菱製薬株式会社 |
miR-33b阻害物質による筋疾患の予防又は治療
|
WO2022245583A1
(en)
|
2021-05-18 |
2022-11-24 |
Alnylam Pharmaceuticals, Inc. |
Sodium-glucose cotransporter-2 (sglt2) irna compositions and methods of use thereof
|
EP4341405A1
(en)
|
2021-05-20 |
2024-03-27 |
Korro Bio, Inc. |
Methods and compositions for adar-mediated editing
|
CA3221923A1
(en)
|
2021-05-29 |
2022-12-08 |
1Globe Health Institute Llc |
Short duplex dna as a novel gene silencing technology and use thereof
|
EP4347829A1
(en)
|
2021-05-29 |
2024-04-10 |
1Globe Health Institute LLC |
Asymmetric short duplex dna as a novel gene silencing technology and use thereof
|
WO2022256283A2
(en)
|
2021-06-01 |
2022-12-08 |
Korro Bio, Inc. |
Methods for restoring protein function using adar
|
TW202317762A
(zh)
|
2021-06-02 |
2023-05-01 |
美商艾拉倫製藥股份有限公司 |
含有類PATATIN磷脂酶結構域3(PNPLA3)的iRNA組成物及其使用方法
|
WO2022256538A1
(en)
|
2021-06-03 |
2022-12-08 |
Synthorx, Inc. |
Head and neck cancer combination therapy comprising an il-2 conjugate and cetuximab
|
IL308743A
(en)
|
2021-06-04 |
2024-01-01 |
Alnylam Pharmaceuticals Inc |
Compositions of human chromosome 9 open reading frame 72 iRNA factor (C9ORF72) and methods of using them
|
AR126085A1
(es)
|
2021-06-08 |
2023-09-13 |
Hoffmann La Roche |
Agonistas de progranulina de oligonucleótido
|
AR126070A1
(es)
|
2021-06-08 |
2023-09-06 |
Alnylam Pharmaceuticals Inc |
Composiciones y métodos para tratar o prevenir la enfermedad de stargardt y/o trastornos asociados con la proteína transportadora de retinol 4 (rbp4)
|
EP4105328A1
(en)
|
2021-06-15 |
2022-12-21 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Antisense-oligonucleotides for prevention of kidney dysfunction promoted by endothelial dysfunction by ephrin-b2 suppression
|
IL309217A
(en)
|
2021-06-18 |
2024-02-01 |
Ionis Pharmaceuticals Inc |
Compounds and Methods for Reducing IFNAR1 Expression
|
WO2023278410A1
(en)
|
2021-06-29 |
2023-01-05 |
Korro Bio, Inc. |
Methods and compositions for adar-mediated editing
|
US20230194709A9
(en)
|
2021-06-29 |
2023-06-22 |
Seagate Technology Llc |
Range information detection using coherent pulse sets with selected waveform characteristics
|
KR20240026203A
(ko)
|
2021-06-30 |
2024-02-27 |
알닐람 파마슈티칼스 인코포레이티드 |
안지오텐시노겐(agt)-관련 장애를 치료하는 방법 및 조성물
|
TW202333748A
(zh)
|
2021-07-19 |
2023-09-01 |
美商艾拉倫製藥股份有限公司 |
用於處置具有或有風險發展非原發性高草酸鹽尿疾病或病症的個體的方法及組成物
|
IL309905A
(en)
|
2021-07-23 |
2024-03-01 |
Alnylam Pharmaceuticals Inc |
IRNA compositions in β-catenin (CTNNB1) and methods of using them
|
WO2023009687A1
(en)
|
2021-07-29 |
2023-02-02 |
Alnylam Pharmaceuticals, Inc. |
3-hydroxy-3-methylglutaryl-coa reductase (hmgcr) irna compositions and methods of use thereof
|
WO2023014677A1
(en)
|
2021-08-03 |
2023-02-09 |
Alnylam Pharmaceuticals, Inc. |
Transthyretin (ttr) irna compositions and methods of use thereof
|
TW202337474A
(zh)
|
2021-08-04 |
2023-10-01 |
美商艾拉倫製藥股份有限公司 |
用於緘默血管收縮素原(AGT)的iRNA組成物及方法
|
TW202334413A
(zh)
|
2021-08-13 |
2023-09-01 |
美商艾拉倫製藥股份有限公司 |
第十二因子(F12)iRNA組成物及其使用方法
|
CA3229305A1
(en)
|
2021-08-16 |
2023-02-23 |
Vib Vzw |
Oligonucleotides for modulating synaptogyrin-3 expression
|
US11833221B2
(en)
|
2021-09-01 |
2023-12-05 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds for reducing DMPK expression
|
WO2023044370A2
(en)
|
2021-09-17 |
2023-03-23 |
Alnylam Pharmaceuticals, Inc. |
Irna compositions and methods for silencing complement component 3 (c3)
|
WO2023044094A1
(en)
|
2021-09-20 |
2023-03-23 |
Alnylam Pharmaceuticals, Inc. |
Inhibin subunit beta e (inhbe) modulator compositions and methods of use thereof
|
WO2023052317A1
(en)
|
2021-09-29 |
2023-04-06 |
F. Hoffmann-La Roche Ag |
Rna editing
|
CA3234835A1
(en)
|
2021-10-22 |
2023-04-27 |
Korro Bio, Inc. |
Methods and compositions for disrupting nrf2-keap1 protein interaction by adar mediated rna editing
|
WO2023076450A2
(en)
|
2021-10-29 |
2023-05-04 |
Alnylam Pharmaceuticals, Inc. |
HUNTINGTIN (HTT) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF
|
TW202333749A
(zh)
|
2021-10-29 |
2023-09-01 |
美商艾拉倫製藥股份有限公司 |
補體因子b(cfb)irna組成物及其使用方法
|
WO2023078883A1
(en)
|
2021-11-03 |
2023-05-11 |
F. Hoffmann-La Roche Ag |
Oligonucleotides for modulating apolipoprotein e4 expression
|
WO2023086292A2
(en)
|
2021-11-10 |
2023-05-19 |
University Of Rochester |
Gata4-targeted therapeutics for treatment of cardiac hypertrophy
|
WO2023086295A2
(en)
|
2021-11-10 |
2023-05-19 |
University Of Rochester |
Antisense oligonucleotides for modifying protein expression
|
AU2022384619A1
(en)
|
2021-11-11 |
2024-04-11 |
F. Hoffmann-La Roche Ag |
Pharmaceutical combinations for treatment of hbv
|
WO2023104693A1
(en)
|
2021-12-07 |
2023-06-15 |
F. Hoffmann-La Roche Ag |
Antisense oligonucleotides targeting actl6b
|
GB202117758D0
(en)
|
2021-12-09 |
2022-01-26 |
Ucl Business Ltd |
Therapeutics for the treatment of neurodegenerative disorders
|
WO2023111336A1
(en)
|
2021-12-17 |
2023-06-22 |
F. Hoffmann-La Roche Ag |
Oligonucleotide gba agonists
|
WO2023111210A1
(en)
|
2021-12-17 |
2023-06-22 |
F. Hoffmann-La Roche Ag |
Combination of oligonucleotides for modulating rtel1 and fubp1
|
WO2023122573A1
(en)
|
2021-12-20 |
2023-06-29 |
Synthorx, Inc. |
Head and neck cancer combination therapy comprising an il-2 conjugate and pembrolizumab
|
WO2023117738A1
(en)
|
2021-12-20 |
2023-06-29 |
F. Hoffmann-La Roche Ag |
Threose nucleic acid antisense oligonucleotides and methods thereof
|
WO2023122762A1
(en)
|
2021-12-22 |
2023-06-29 |
Camp4 Therapeutics Corporation |
Modulation of gene transcription using antisense oligonucleotides targeting regulatory rnas
|
WO2023122750A1
(en)
|
2021-12-23 |
2023-06-29 |
Synthorx, Inc. |
Cancer combination therapy with il-2 conjugates and cetuximab
|
WO2023141507A1
(en)
|
2022-01-20 |
2023-07-27 |
Genentech, Inc. |
Antisense oligonucleotides for modulating tmem106b expression
|
WO2023141314A2
(en)
|
2022-01-24 |
2023-07-27 |
Alnylam Pharmaceuticals, Inc. |
Heparin sulfate biosynthesis pathway enzyme irna agent compositions and methods of use thereof
|
WO2023156652A1
(en)
|
2022-02-21 |
2023-08-24 |
F. Hoffmann-La Roche Ag |
Antisense oligonucleotide
|
WO2023217890A1
(en)
|
2022-05-10 |
2023-11-16 |
F. Hoffmann-La Roche Ag |
Antisense oligonucleotides targeting cfp-elk1 intergene region
|
WO2023222858A1
(en)
|
2022-05-18 |
2023-11-23 |
F. Hoffmann-La Roche Ag |
Improved oligonucleotides targeting rna binding protein sites
|
WO2023240277A2
(en)
|
2022-06-10 |
2023-12-14 |
Camp4 Therapeutics Corporation |
Methods of modulating progranulin expression using antisense oligonucleotides targeting regulatory rnas
|
WO2023242324A1
(en)
|
2022-06-17 |
2023-12-21 |
F. Hoffmann-La Roche Ag |
Antisense oligonucleotides for targeting progranulin
|
WO2024040041A1
(en)
|
2022-08-15 |
2024-02-22 |
Dicerna Pharmaceuticals, Inc. |
Regulation of activity of rnai molecules
|
WO2024039776A2
(en)
|
2022-08-18 |
2024-02-22 |
Alnylam Pharmaceuticals, Inc. |
Universal non-targeting sirna compositions and methods of use thereof
|
EP4332221A1
(en)
|
2022-08-29 |
2024-03-06 |
Roche Innovation Center Copenhagen A/S |
Threose nucleic acid antisense oligonucleotides and methods thereof
|
WO2024050261A1
(en)
|
2022-08-29 |
2024-03-07 |
University Of Rochester |
Antisense oligonucleotide-based anti-fibrotic therapeutics
|
WO2024052403A1
(en)
|
2022-09-06 |
2024-03-14 |
F. Hoffmann-La Roche Ag |
Double-stranded rna molecule for administration to the eye
|
WO2024059165A1
(en)
|
2022-09-15 |
2024-03-21 |
Alnylam Pharmaceuticals, Inc. |
17b-hydroxysteroid dehydrogenase type 13 (hsd17b13) irna compositions and methods of use thereof
|