DK1447399T3 - 2-oxo-1-pyrrolidinderivat og dets farmaceutiske anvendelser - Google Patents
2-oxo-1-pyrrolidinderivat og dets farmaceutiske anvendelserInfo
- Publication number
- DK1447399T3 DK1447399T3 DK04007733T DK04007733T DK1447399T3 DK 1447399 T3 DK1447399 T3 DK 1447399T3 DK 04007733 T DK04007733 T DK 04007733T DK 04007733 T DK04007733 T DK 04007733T DK 1447399 T3 DK1447399 T3 DK 1447399T3
- Authority
- DK
- Denmark
- Prior art keywords
- sup
- oxo
- pharmaceutical uses
- pyrrolidine derivative
- pyrrolidine
- Prior art date
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- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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GBGB0004297.8A GB0004297D0 (en) | 2000-02-23 | 2000-02-23 | 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses |
PCT/EP2001/001992 WO2001062726A2 (en) | 2000-02-23 | 2001-02-21 | 2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses |
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DK04007878.4T DK1452524T3 (da) | 2000-02-23 | 2001-02-21 | "2-oxo-1-pyrrolidinderivat og dets farmaceutiske anvendelser" |
DK01925354T DK1265862T3 (da) | 2000-02-23 | 2001-02-21 | 2-oxo-1-pyrrolidinderivater, fremgangsmåder til fremstilling heraf og deres anvendelse |
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DK01925354T DK1265862T3 (da) | 2000-02-23 | 2001-02-21 | 2-oxo-1-pyrrolidinderivater, fremgangsmåder til fremstilling heraf og deres anvendelse |
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Families Citing this family (157)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7365093B2 (en) * | 1994-08-19 | 2008-04-29 | Abbott Laboratories | Endothelin antagonists |
GB0004297D0 (en) * | 2000-02-23 | 2000-04-12 | Ucb Sa | 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses |
US6686477B2 (en) | 2000-09-29 | 2004-02-03 | Eastman Chemical Company | Highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using same |
JP2004523557A (ja) * | 2001-02-23 | 2004-08-05 | ジョンズ・ホプキンス・ユニバーシティ | チック、振せん、および関連疾患の治療 |
ATE410412T1 (de) | 2001-08-10 | 2008-10-15 | Ucb Pharma Sa | Oxopyrrolidin verbindungen, verfahren zur herstellung dieser verbindungen und deren verwendung zur herstellung von levetiracetam und analogen |
CA2461961A1 (en) * | 2001-10-08 | 2003-04-17 | Ucb, S.A. | Use of 2-oxo-1-pyrrolidine derivatives for the treatment of dyskinesia and movement disorders |
CN1604776A (zh) | 2001-10-16 | 2005-04-06 | 记忆药物公司 | 作为用于治疗神经病综合症的pde-4抑制剂的4-(4-烷氧基-3-羟基苯基)-2-吡咯烷酮衍生物 |
AU2003242538A1 (en) * | 2002-05-14 | 2003-11-11 | Ucb, S.A. | Use of 2-oxo-1-pyrrolidone derivatives for the preparation of a drug |
AU2004204338A1 (en) * | 2003-01-13 | 2004-07-29 | Ucb | Hydrogenation catalysts |
EP1517893A2 (de) * | 2003-02-03 | 2005-03-30 | Teva Pharmaceutical Industries Limited | Verfahren zur herstellung von levetiracetam |
ES2214147B1 (es) | 2003-02-28 | 2005-10-01 | Farma-Lepori S.A. | Procedimiento de obtencion de un agente antiepileptico. |
TR200503397T1 (tr) * | 2003-03-18 | 2007-03-21 | Hetero Drugs Limited | Levetirasetam'ın yeni kristal formları. |
RU2232578C1 (ru) * | 2003-04-10 | 2004-07-20 | Ахапкина Валентина Ивановна | Вещество, обладающее антидепрессивной активностью |
SG169900A1 (en) | 2003-04-16 | 2011-04-29 | Memory Pharm Corp | 4 - (3,4 - disubstituted phenyl) - pyrrolidin-2-one compounds as phosphodiesterase 4 inhibitors |
US7034051B2 (en) * | 2003-08-28 | 2006-04-25 | Adolor Corporation | Fused bicyclic carboxamide derivatives and methods of their use |
EP1663968A1 (de) * | 2003-09-05 | 2006-06-07 | Ranbaxy Laboratories Limited | Verfahren zur herstellung von reinem levetiracetam |
US7629474B2 (en) * | 2003-09-24 | 2009-12-08 | Ucb Pharma S.A. | Process for preparing 2-oxo-1-pyrrolidine derivatives |
BRPI0417157A (pt) * | 2003-12-02 | 2007-03-06 | Ucb Sa | composto, composição farmacêutica, e, uso de um composto ou de uma composição farmacêutica |
KR101159870B1 (ko) | 2004-06-11 | 2012-06-25 | 유씨비 소시에떼아노님 | 분자내 알릴화에 의해 2-옥소-1-피롤리딘 유도체를제조하는 방법 |
EP1831154B1 (de) * | 2004-06-21 | 2010-01-13 | Warner-Lambert Company LLC | Herstellung von pregabalin und verwandten verbindungen |
US7427601B2 (en) * | 2004-06-24 | 2008-09-23 | Schwarz Pharma Ag | Method for treating tremor |
WO2006044955A1 (en) * | 2004-10-20 | 2006-04-27 | Memory Pharmaceuticals Corporation | Phosphodiesterase 4 inhibitors |
CA2488325C (en) * | 2004-11-22 | 2010-08-24 | Apotex Pharmachem Inc. | Improved process for the preparation of (s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide and (r)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide |
CA2610695A1 (en) | 2005-06-01 | 2006-12-07 | Ucb Pharma, S.A. | 2-oxo-1-pyrrolidine derivatives and their therapeutic use on the central nervous system |
EP1731149A1 (de) * | 2005-06-08 | 2006-12-13 | Ucb S.A. | Verwendung von Brivaracetam in der Behandlung von Krankheiten, die durch vorschreitende Myoloniusepilepsie gekenneichnet sind |
MY143249A (en) * | 2005-09-15 | 2011-04-15 | Ucb Pharma Sa | 4-substituted pyrrolidin-2-ones and their use |
JP2007153755A (ja) * | 2005-12-01 | 2007-06-21 | Gifu Univ | プロリン類縁体 |
WO2007065634A1 (en) * | 2005-12-07 | 2007-06-14 | Ucb Pharma, S.A. | 3-carboxy- 2-oxo-1 -pyrrolidine derivatives and their uses |
US8338621B2 (en) | 2005-12-21 | 2012-12-25 | Ucb S.A. | Process for the preparation of 2-oxo-1-pyrrolidine derivatives |
LV13630B (en) * | 2006-03-16 | 2007-12-20 | Olainfarm As | Method of preparation and use of pharmaceutically active n-carbamoylmethyl-4(r)-phenyl-2-pyrrolidinone |
BRPI0712325A2 (pt) * | 2006-06-08 | 2012-01-10 | Ucb Pharma Sa | processo para a preparação de co-cristais de pirrolidinonas, co-cristal, composição farmacêutica, e, uso de um co-cristal |
KR101518427B1 (ko) | 2006-06-15 | 2015-05-08 | 유씨비 파르마 게엠베하 | 상승적 항경련 효과를 갖는 약제학적 조성물 |
WO2008021666A2 (en) * | 2006-08-18 | 2008-02-21 | Morton Grove Pharmaceuticals, Inc. | Stable liquid levetiracetam compositions and methods |
KR101181194B1 (ko) * | 2006-10-18 | 2012-09-18 | 화이자 프로덕츠 인코포레이티드 | 바이아릴 에터 우레아 화합물 |
WO2008103319A2 (en) | 2007-02-16 | 2008-08-28 | Ark Diagnostics, Inc. | Compounds and methods for use in detecting gabapentin |
WO2008132139A2 (en) * | 2007-04-27 | 2008-11-06 | Ucb Pharma S.A. | New heterocyclic derivatives useful for the treatment of cns disorders |
US20090082422A1 (en) * | 2007-09-26 | 2009-03-26 | Protia, Llc | Deuterium-enriched levetiracetam |
CA2715685C (en) * | 2008-03-03 | 2015-04-28 | Eric Schenkel | Pharmaceutical solutions, process of preparation and therapeutic uses |
US7741327B2 (en) | 2008-04-16 | 2010-06-22 | Hoffmann-La Roche Inc. | Pyrrolidinone glucokinase activators |
US20110212944A1 (en) * | 2008-07-01 | 2011-09-01 | Julie Liu | 2-oxo-1-pyrrolidine derivatives |
EP2147911A1 (de) | 2008-07-24 | 2010-01-27 | ZaCh System S.p.A. | Verfahren zur Herstellung von Levetiracetam |
JP4644881B2 (ja) * | 2008-09-19 | 2011-03-09 | 高砂香料工業株式会社 | ルテニウム錯体の製造方法 |
CN102227217A (zh) | 2008-10-16 | 2011-10-26 | 约翰斯.霍普金斯大学 | 改善认知功能的方法和组合物 |
US8168756B2 (en) | 2008-10-24 | 2012-05-01 | Ark Diagnostics, Inc. | Levetiracetam immunoassays |
EP2341777B1 (de) * | 2008-11-07 | 2015-01-21 | NovaBay Pharmaceuticals, Inc. | Antimikrobielle oxazolidinon-, hydantoin- und imidazolidinon-zusammensetzungen |
ES2602606T3 (es) * | 2008-11-18 | 2017-02-21 | Ucb Biopharma Sprl | Formulaciones de liberación prolongada que comprenden un derivado de 2-oxo-1-pirrolidina |
KR101689688B1 (ko) * | 2008-11-18 | 2016-12-26 | 유씨비 파마, 에스.에이. | 2옥소1피롤리딘 유도체를 포함하는 지연 방출형 제형 |
FR2939311A1 (fr) * | 2008-12-08 | 2010-06-11 | Oreal | Utilisation d'un derive diester de pyrrolidinone 4-carboxy comme solvant dans les compositions cosmetiques ; compositions cosmetiques les contenant |
US8563036B2 (en) | 2009-02-09 | 2013-10-22 | Ucb Pharma, S.A. | Pharmaceutical compositions comprising Brivaracetam |
US8846411B2 (en) * | 2009-06-11 | 2014-09-30 | Microgenics Corporation | Derivatives, reagents, and immunoassay for detecting levetiracetam |
US20120171125A1 (en) | 2009-08-07 | 2012-07-05 | Ucb Pharma, S.A. | Methods for Enhancing the Cognitive Function |
US7939676B2 (en) | 2009-09-17 | 2011-05-10 | Zach System S.P.A. | Process for the preparation of levetiracetam |
US8487591B1 (en) | 2009-12-31 | 2013-07-16 | Cirrus Logic, Inc. | Power control system with power drop out immunity and uncompromised startup time |
SI2491045T1 (sl) | 2009-10-23 | 2016-04-29 | Ucb Biopharma Sprl | 2-okso-1-pirolidinil imidazotiadiazolni derivati |
PL389364A1 (pl) | 2009-10-23 | 2011-04-26 | Uniwersytet Jagielloński | Nowe zastosowanie pochodnych 2-pirolidonu |
EP2533645B1 (de) | 2010-02-09 | 2016-07-27 | The Johns Hopkins University | Verfahren und zusammensetzungen zur verbesserung von kognitiven funktionen |
FR2961099B1 (fr) | 2010-06-09 | 2012-06-15 | Oreal | Derives de 2-pyrrolidone fonctionnalisee par un radical ester, acide ou amide, la composition cosmetique les comprenant et leur utilisation pour le conditionnement des matieres keratiniques |
FR2961098A1 (fr) | 2010-06-09 | 2011-12-16 | Oreal | Composition comprenant au moins une 2-pyrrolidone fonctionnalisee en position 4 par un acide carboxylique ou amide, et au moins un colorant direct ou un pigment pour la teinture des fibres keratiniques |
FR2961101B1 (fr) | 2010-06-09 | 2013-01-25 | Oreal | Composition comprenant au moins une 2-pyrrolidone fonctionnalisee par un radical ester ou amide, et au moins un pigment ou un colorant direct pour la teinture des matieres keratiniques |
US8866452B1 (en) | 2010-08-11 | 2014-10-21 | Cirrus Logic, Inc. | Variable minimum input voltage based switching in an electronic power control system |
US9510401B1 (en) | 2010-08-24 | 2016-11-29 | Cirrus Logic, Inc. | Reduced standby power in an electronic power control system |
US8466297B2 (en) | 2010-11-01 | 2013-06-18 | Milan Soukup | Manufacturing process for (S)-Pregabalin |
CA2818025A1 (en) | 2010-11-15 | 2012-05-24 | Agenebio, Inc. | Pyridazine derivatives, compositions and methods for treating cognitive impairment |
US20120214859A1 (en) * | 2011-02-09 | 2012-08-23 | Michela Gallagher | Methods and compositions for improving cognitive function |
ME02351B (de) | 2011-04-18 | 2016-06-20 | Ucb Biopharma Sprl | 2-oxo-1-imidiazolidinyl-imidazothiadiazol-derivate |
CN103636109B (zh) | 2011-06-03 | 2016-08-17 | 塞瑞斯逻辑公司 | 用于操作开关电力转换器的方法和装置以及电力分配系统 |
IN2014CN03043A (de) | 2011-09-30 | 2015-07-03 | Univ Tufts | |
WO2013100568A1 (en) * | 2011-12-27 | 2013-07-04 | Bio-Pharm Solutions Co., Ltd. | Phenyl carbamate compounds for use in preventing or treating stroke |
TW201408293A (zh) * | 2012-07-05 | 2014-03-01 | Merz Pharma Gmbh & Co Kgaa | (r)-苯基披喇瑟盪於治療疾病相關疲勞之用途 |
TW201408294A (zh) * | 2012-07-05 | 2014-03-01 | Merz Pharma Gmbh & Co Kgaa | (r)-苯基披喇瑟盪於治療帕金森氏症之用除 |
CA2885369A1 (en) | 2012-09-28 | 2014-04-03 | Tufts University | Uridine diphosphate derivatives, prodrugs, compositions and uses thereof |
EP2919788A4 (de) | 2012-11-14 | 2016-05-25 | Univ Johns Hopkins | Verfahren und zusammensetzungen zur behandlung von schizophrenie |
DK2928865T3 (en) | 2012-12-07 | 2018-06-18 | Merck Sharp & Dohme | BIOCATALYTIC TRANSAMINATION PROCEDURE |
WO2014087367A2 (en) * | 2012-12-09 | 2014-06-12 | Mahesh Kandula | Compositions and methods for the treatment of neurological diseases and its associated complications |
EP2945942B1 (de) | 2013-01-18 | 2018-05-09 | ARK Diagnostics, Inc. | Voriconazol-immunoassays |
ES2674704T3 (es) | 2013-02-13 | 2018-07-03 | Ark Diagnostics, Inc. | Inmunoensayos de posaconazol |
CA2904180C (en) | 2013-03-13 | 2022-05-10 | Tufts University | Uridine nucleoside derivatives, compositions and methods of use |
AR095442A1 (es) | 2013-03-13 | 2015-10-14 | Univ Tufts | Derivados de nucleósido de uridina, composiciones y métodos de uso |
EP2968237A4 (de) | 2013-03-15 | 2016-08-31 | Univ Johns Hopkins | Verfahren und zusammensetzungen zur verbesserung der kognitiven funktion |
DK2968220T3 (da) | 2013-03-15 | 2021-06-14 | Agenebio Inc | Fremgangsmåder og sammensætninger til forbedring af kognitiv funktion |
CN103342672B (zh) * | 2013-07-02 | 2015-12-23 | 扬州大学 | 取代吡咯烷-2-酮的新合成方法 |
JP6465634B2 (ja) * | 2013-12-05 | 2019-02-06 | 株式会社日本触媒 | 環状アミド基含有重合体 |
JP6453632B2 (ja) * | 2013-12-05 | 2019-01-16 | 株式会社日本触媒 | 環状アミドアクリレート含有組成物およびその製造方法 |
EP3083569B1 (de) | 2013-12-20 | 2022-01-26 | Agenebio, Inc. | Benzodiazepinderivate, zusammensetzungen und verfahren zur behandlung von kognitiven störungen |
ME03518B (de) | 2014-01-21 | 2020-04-20 | Janssen Pharmaceutica Nv | Kombinationen mit positiven allosterischen modulatoren von metabotropem glutamatergen rezeptor vom subtyp 2 und deren verwendung |
WO2015110435A1 (en) | 2014-01-21 | 2015-07-30 | Janssen Pharmaceutica Nv | Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use |
CN104098497B (zh) * | 2014-06-17 | 2016-04-13 | 王庚禹 | 一种新的酰胺类化合物 |
WO2016075082A1 (en) | 2014-11-10 | 2016-05-19 | Sandoz Ag | Stereoselective reductive amination of alpha-chiral aldehydes using omega-transaminases for the synthesis of precursors of pregabalin and brivaracetam |
US20180021307A1 (en) | 2015-02-20 | 2018-01-25 | Ucb Biopharma Sprl | Combination Treatment |
WO2016191435A1 (en) * | 2015-05-25 | 2016-12-01 | Peng Wang | Processes to produce brivaracetam |
CN108689968B (zh) * | 2015-05-25 | 2020-09-15 | 苏州鹏旭医药科技有限公司 | 两种化合物及其制备方法和在合成布瓦西坦中的用途 |
CN106365986B (zh) * | 2015-07-21 | 2019-01-08 | 苏州鹏旭医药科技有限公司 | 化合物及其制备方法和在合成布瓦西坦中的用途 |
CN107922457B (zh) | 2015-06-19 | 2022-05-13 | 森托瑞恩生物制药公司 | 用于控制药物释放的递送系统 |
WO2016205739A1 (en) | 2015-06-19 | 2016-12-22 | Belew Mekonnen | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
WO2017076737A1 (en) | 2015-11-03 | 2017-05-11 | Ucb Biopharma Sprl | Continuous process for preparing brivaracetam |
SI3371150T1 (sl) | 2015-11-03 | 2021-11-30 | UCB Biopharma SRL | Postopek za pripravo brivaracetama |
CN106748748B (zh) * | 2015-11-10 | 2021-08-24 | 成都国为生物医药有限公司 | 一种布瓦西坦的制备方法及其中间体 |
EP3397253A1 (de) | 2015-12-30 | 2018-11-07 | Adamas Pharmaceuticals, Inc. | Verfahren und zusammensetzungen zur behandlung von erkrankungen im zusammenhang mit krämpfen |
CN105646319B (zh) * | 2015-12-30 | 2018-05-18 | 佛山市隆信医药科技有限公司 | 一种布瓦西坦的制备方法 |
EP3452447A4 (de) | 2016-05-03 | 2019-12-18 | The Regents of The University of California | Inhibitoren der ires-vermittelten proteinsynthese |
RU2629117C1 (ru) * | 2016-06-14 | 2017-08-24 | Сизов Владимир Владимирович | Способ получения 4-замещенного 2-[2-оксо-1-пирролидинил] ацетамида |
CN107513031B (zh) * | 2016-06-16 | 2022-08-02 | 上海医药集团股份有限公司 | 一种2-氧代-1-吡咯烷手性衍生物的制备方法 |
BR112019012821A2 (pt) | 2016-12-19 | 2019-11-26 | Agenebio Inc | derivados de benzodiazepina, composições e métodos para o tratamento do comprometimento cognitivo |
US20180170941A1 (en) | 2016-12-19 | 2018-06-21 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
AU2018210393A1 (en) | 2017-01-20 | 2019-07-25 | The Regents Of The University Of California | Inhibitors of the N-terminal domain of the androgen receptor |
WO2018141276A1 (zh) * | 2017-02-05 | 2018-08-09 | 苏州鹏旭医药科技有限公司 | 布瓦西坦中间体的晶型a及其制备方法和布瓦西坦的晶型c及其制备方法 |
CN106866483A (zh) * | 2017-02-05 | 2017-06-20 | 苏州鹏旭医药科技有限公司 | 布瓦西坦的晶型c及其制备方法 |
CN108503610B (zh) | 2017-02-24 | 2019-09-13 | 北京艾百诺医药股份有限公司 | 一种光学纯的(r)-4-正丙基-二氢呋喃-2(3h)-酮的制备方法 |
CN108658831B (zh) * | 2017-03-30 | 2021-11-05 | 江苏豪森药业集团有限公司 | 2-氧代-1-吡咯烷衍生物或其盐的制备方法 |
EP3615513B1 (de) | 2017-04-24 | 2022-07-20 | Tesaro, Inc. | Verfahren zur herstellung von nirapaib |
JP7221227B2 (ja) | 2017-06-30 | 2023-02-13 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 発毛を調節するための組成物及び方法 |
CN107793342A (zh) * | 2017-10-19 | 2018-03-13 | 丽珠集团新北江制药股份有限公司 | 一种布瓦西坦的制备方法 |
CN107721896A (zh) * | 2017-10-19 | 2018-02-23 | 丽珠集团新北江制药股份有限公司 | 一种布瓦西坦的中间体的制备方法 |
MX2020005472A (es) | 2017-11-30 | 2020-11-11 | Centurion Biopharma Corp | Sistemas de administración de fármacos a base de maitansinoide. |
CN111712511B (zh) | 2017-11-30 | 2024-07-16 | 拉德克斯公司 | 澳瑞他汀e衍生物的白蛋白结合产物 |
WO2019152536A1 (en) | 2018-01-30 | 2019-08-08 | The Regents Of The University Of California | Inhibitors of the wnt/beta-catenin pathway |
CN108147988B (zh) * | 2018-02-13 | 2020-10-02 | 扬州奥锐特药业有限公司 | 一种高手性纯度内酰胺化合物的制备方法 |
CN108530402B (zh) * | 2018-04-10 | 2020-06-26 | 浙江工业大学 | 一种(R)-3-丙基-γ-丁内酯的制备方法 |
EP3566760A1 (de) * | 2018-05-07 | 2019-11-13 | Universite Libre De Bruxelles | Verfahren zur keimbildung von kristallen aus einer lösung in einem kapillarrohr |
ES2947618T3 (es) | 2018-05-08 | 2023-08-14 | UCB Biopharma SRL | Derivados de 1-imidazotiadiazolo-2H-pirrol-5-ona |
CN112601749B (zh) | 2018-06-19 | 2024-03-26 | 艾吉因生物股份有限公司 | 用于治疗认知损害的苯并二氮杂环庚三烯衍生物,组合物和方法 |
CN110615744B (zh) * | 2018-06-20 | 2023-01-06 | 上海朴颐化学科技有限公司 | 一种布瓦西坦中间体及其制备方法 |
WO2020006489A1 (en) | 2018-06-29 | 2020-01-02 | The Regents Of The University Of California | New molecular tweezers against neurological disorders and viral infections |
RU2699669C1 (ru) * | 2018-07-04 | 2019-09-09 | Общество С Ограниченной Ответственностью "Валента - Интеллект" | Новые составы N-карбамоилметил-4-фенил-2-пирролидона |
SG11202100429TA (en) | 2018-07-27 | 2021-02-25 | California Inst Of Techn | Cdk inhibitors and uses thereof |
US11214568B2 (en) | 2018-10-18 | 2022-01-04 | California Institute Of Technology | Gem-disubstituted pyrrolidines, piperazines, and diazepanes, and compositions and methods of making the same |
US20220047548A1 (en) | 2018-12-04 | 2022-02-17 | Metys Pharmaceuticals AG | SYNERGISTIC COMPOSITIONS COMPRISING (R)-2-(2-OXOPYRROLIDIN-1-YL)BUTANAMIDE AND (S)-2-(2-e OXOPYRROLEDIN-1-YL)BUTANAMEDE IN A NON-RACEMIC RATIO |
CN109932442A (zh) * | 2019-03-04 | 2019-06-25 | 成都美域高制药有限公司 | 一种布瓦西坦异构体的检测方法 |
WO2020198323A1 (en) | 2019-03-25 | 2020-10-01 | California Institute Of Technology | Prmt5 inhibitors and uses thereof |
SG11202112827QA (en) | 2019-06-04 | 2021-12-30 | Hager Biosciences Llc | Imidazolo derivatives, compositions and methods as orexin antagonists |
CN110357752A (zh) * | 2019-08-15 | 2019-10-22 | 中国工程物理研究院化工材料研究所 | 一种快速制备均匀包覆含能材料的方法 |
RU2732245C1 (ru) * | 2019-08-30 | 2020-09-14 | Ооо "Валента-Интеллект" | Новые составы n-карбамоилметил-4-фенил-2-пирролидона для лечения и профилактики ожирения |
CN110551050A (zh) * | 2019-09-02 | 2019-12-10 | 南通大学 | 一种2-[3’-(N-Boc-吡咯基)]-苯甲酸的合成方法 |
US10781170B1 (en) | 2019-10-21 | 2020-09-22 | Divi's Laboratories Ltd. | Process for preparing Brivaracetam |
US20230100559A1 (en) | 2020-01-07 | 2023-03-30 | The Trustees Of Princeton University | Compositions and Methods for Treatment of Disease by Manipulation of Serine Metabolism |
EP4087847A4 (de) | 2020-01-10 | 2024-02-28 | The Regents of the University of California | Zusammensetzungen und verfahren zur behandlung von neurodegenerativen erkrankungen |
US20230174460A1 (en) | 2020-04-21 | 2023-06-08 | President And Fellowes Of Harvard College | Afmt analogs and their use in methods of treating parkinson's disease |
LV15614A (lv) | 2020-07-30 | 2022-02-20 | Latvijas Organiskās Sintēzes Institūts | 2-(2-okso-3-pirolin-1-il)acetamīdi kā pretkrampju līdzekļi |
US20230265082A1 (en) | 2020-08-10 | 2023-08-24 | Dana-Farber Cancer Institute, Inc. | Substituted 1,2,4-oxadiazoles as small molecule inhibitors of ubiquitin-specific protease 28 |
CA3191166A1 (en) | 2020-08-10 | 2022-02-17 | Dana-Farber Cancer Institute, Inc. | Substituted 3-amino-4-methylbenzenesulfonamides as small molecule inhibitors of ubiquitin-specific protease 28 |
WO2022035806A1 (en) | 2020-08-10 | 2022-02-17 | Dana-Farber Cancer Institute, Inc. | Fused tricyclic pyrimidine-thieno-pyridine small molecule inhibitors of ubiquitin-specific protease 28 |
CN116323571A (zh) | 2020-10-23 | 2023-06-23 | 丹娜法伯癌症研究院 | 肌酸激酶(ck)的共价抑制剂以及其用于治疗和预防癌症的用途 |
WO2022133237A2 (en) | 2020-12-18 | 2022-06-23 | Cornell University | Methods of treating neurodegenerative disorders and stat3-linked cancers using suppressors of electron leak |
WO2022140289A1 (en) | 2020-12-21 | 2022-06-30 | Cornell University | Peptide-linked drug delivery system |
US20240132480A1 (en) | 2021-01-08 | 2024-04-25 | Cornell University | Inhibitors of mycobacterium tuberculosis lipoamide dehydrogenase |
US11400074B1 (en) | 2021-02-01 | 2022-08-02 | Divi's Laboratories Ltd. | Enzymatic process for the preparation of (2S)-2-[(4R)-2-oxo-4-propyl-pyrrolidin-1-yl]butyric acid and its conversion into brivaracetam |
US11384050B1 (en) | 2021-02-03 | 2022-07-12 | Vitaworks Ip, Llc | Method for preparing levetiracetam and intermediates thereof |
CN114948953A (zh) * | 2021-06-29 | 2022-08-30 | 四川大学华西医院 | 一种杂原子取代芳香类化合物及其盐的用途 |
CN113511994B (zh) * | 2021-08-16 | 2023-03-21 | 江苏八巨药业有限公司 | 一种左乙拉西坦的制备方法 |
CN114634437B (zh) * | 2022-03-29 | 2023-05-30 | 武汉氟本氘合新材料科技有限公司 | 一种布瓦西坦的简易制备方法 |
US11884623B2 (en) | 2022-05-23 | 2024-01-30 | Divi's Laboratories Ltd. | Process for the preparation of (R)-4-propyl pyrrolidine-2-one, a key intermediate for synthesis of brivaracetam |
WO2023250157A1 (en) | 2022-06-24 | 2023-12-28 | Cornell University | Inhibitors of mycobacterium tuberculosis lipoamide dehydrogenase |
WO2024013209A1 (en) | 2022-07-13 | 2024-01-18 | Astrazeneca Ab | Pcsk9 inhibitors and methods of use thereof |
WO2024039886A1 (en) | 2022-08-19 | 2024-02-22 | Agenebio, Inc. | Benzazepine derivatives, compositions, and methods for treating cognitive impairment |
WO2024049236A1 (ko) * | 2022-08-31 | 2024-03-07 | 고려대학교 산학협력단 | 키랄 감마 락탐 유도체 또는 이의 약학적으로 허용가능한 염 및 이의 제조방법 |
WO2024163711A1 (en) | 2023-02-02 | 2024-08-08 | Osmoses Inc. | Norbornyl benzocyclobutene ladder polymer composite membranes for fluid separation |
EP4431086A1 (de) | 2023-03-16 | 2024-09-18 | Adalvo Limited | Pharmazeutische zusammensetzung mit (2s)-2-[(4r)-2-oxo-4-propyltetrahydro-1h-pyrrol-1-yl)butanamid |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE92031C (de) | ||||
DD92031A (de) * | ||||
US2836599A (en) * | 1957-03-07 | 1958-05-27 | Aerojet General Co | Nu-(carboxyalkyl) dinitro lactams |
GB1309692A (en) * | 1970-02-13 | 1973-03-14 | Ucb Sa | N-substituted lactams |
GB1039113A (en) | 1964-08-06 | 1966-08-17 | Ucb Sa | New n-substituted lactams |
US4008281A (en) | 1973-12-03 | 1977-02-15 | Monsanto Company | Asymmetric catalysis |
HU177239B (hu) | 1974-10-15 | 1981-08-28 | Monsanto Co | Eljárás N-acetamido-L-alanin-származékok előállítására α-acetamido-akrilsav-származékok aszimmetrikus katalitikus hídrogénezésével |
GB8412358D0 (en) | 1984-05-15 | 1984-06-20 | Ucb Sa | Pharmaceutical composition |
CN1015542B (zh) * | 1984-05-15 | 1992-02-19 | 尤西比公司 | (R)-α-乙基-2-氧代-1-吡咯烷乙酰胺的制备方法 |
GB8412357D0 (en) * | 1984-05-15 | 1984-06-20 | Ucb Sa | Pharmaceutical composition |
JPS60166692A (ja) | 1984-09-28 | 1985-08-29 | Kazuo Achinami | 新規不斉還元試薬 |
CH666891A5 (de) * | 1985-11-26 | 1988-08-31 | Lonza Ag | 4-alkoxy-2-oxo-pyrrolidin-1-yl-essigsaeure-c(1)-c(4)-alkylester, deren herstellung und verwendung. |
DE3719873A1 (de) * | 1987-06-13 | 1988-12-29 | Basf Ag | Verfahren zur herstellung von itaconsaeurediestern und itaconsaeure |
JPH0757758B2 (ja) | 1988-10-24 | 1995-06-21 | 高砂香料工業株式会社 | ルテニウム―ホスフィン錯体 |
GB8827389D0 (en) | 1988-11-23 | 1988-12-29 | Ucb Sa | Process for preparation of(s)alpha-ethyl-2-oxo-1-pyrrolidineacetamide |
SK279285B6 (sk) * | 1991-05-02 | 1998-09-09 | Daiichi Pharmaceutical Co. | Použitie n-(2,6-dimetylfenyl)-2-(2-oxo-1-pyrolidin |
US5171892A (en) | 1991-07-02 | 1992-12-15 | E. I. Du Pont De Nemours And Company | Chiral phospholanes via chiral 1,4-diol cyclic sulfates |
GB9319732D0 (en) | 1993-09-24 | 1993-11-10 | Ucb Sa | Use of (s)-alpha-ethyl-2-oxo-l-pyrrolidineacetamide for the treatment of anxiety |
JPH1180027A (ja) * | 1997-09-12 | 1999-03-23 | Dai Ichi Seiyaku Co Ltd | 向知性薬 |
TW544311B (en) * | 1998-08-06 | 2003-08-01 | Daiichi Seiyaku Co | Therapeutic or preventive agent for intractable epilepsies |
CZ20001055A3 (cs) * | 1998-10-02 | 2000-08-16 | Dupont Pharmaceuticals Company | Nové laktamové inhibitory metaloproteázy |
ATE361751T1 (de) | 1999-12-01 | 2007-06-15 | Ucb Sa | Ein pyrrolidinacetatderivat zur behandlung von chronischem oder neuropathischem schmerz |
GB0004297D0 (en) * | 2000-02-23 | 2000-04-12 | Ucb Sa | 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses |
US6686477B2 (en) | 2000-09-29 | 2004-02-03 | Eastman Chemical Company | Highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using same |
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