CN1596100A - 可食用组合物及含可食用外壳的制剂 - Google Patents
可食用组合物及含可食用外壳的制剂 Download PDFInfo
- Publication number
- CN1596100A CN1596100A CNA028236386A CN02823638A CN1596100A CN 1596100 A CN1596100 A CN 1596100A CN A028236386 A CNA028236386 A CN A028236386A CN 02823638 A CN02823638 A CN 02823638A CN 1596100 A CN1596100 A CN 1596100A
- Authority
- CN
- China
- Prior art keywords
- preparation
- product
- shell
- crystallizable carbohydrate
- substrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/02—Apparatus specially adapted for manufacture or treatment of sweetmeats or confectionery; Accessories therefor
- A23G3/04—Sugar-cookers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G1/00—Cocoa; Cocoa products, e.g. chocolate; Substitutes therefor
- A23G1/30—Cocoa products, e.g. chocolate; Substitutes therefor
- A23G1/50—Cocoa products, e.g. chocolate; Substitutes therefor characterised by shape, structure or physical form, e.g. products with an inedible support
- A23G1/54—Composite products, e.g. layered laminated, coated, filled
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/0002—Processes of manufacture not relating to composition and compounding ingredients
- A23G3/0004—Processes specially adapted for manufacture or treatment of sweetmeats or confectionery
- A23G3/0019—Shaping of liquid, paste, powder; Manufacture of moulded articles, e.g. modelling, moulding, calendering
- A23G3/0025—Processes in which the material is shaped at least partially in a mould in the hollows of a surface, a drum, an endless band, or by a drop-by-drop casting or dispensing of the material on a surface, e.g. injection moulding, transfer moulding
- A23G3/0029—Moulding processes for hollow products, e.g. opened shell
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/364—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
- A23G3/368—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins containing vitamins, antibiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/50—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by shape, structure or physical form, e.g. products with supported structure
- A23G3/54—Composite products, e.g. layered, coated, filled
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/005—Coating of tablets or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/06—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of pills, lozenges or dragees
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/282—Organic compounds, e.g. fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/282—Organic compounds, e.g. fats
- A61K9/2826—Sugars or sugar alcohols, e.g. sucrose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/2873—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2893—Tablet coating processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
- B30B11/02—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space
- B30B11/08—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space co-operating with moulds carried by a turntable
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
- B30B11/34—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses for coating articles, e.g. tablets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B15/00—Details of, or accessories for, presses; Auxiliary measures in connection with pressing
- B30B15/30—Feeding material to presses
- B30B15/302—Feeding material in particulate or plastic state to moulding presses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
- Y10T428/1352—Polymer or resin containing [i.e., natural or synthetic]
Abstract
本发明涉及一种至少含有占产品总重量约50%的可结晶碳水化合物的可食用产品,其中至少约90%的可结晶碳水化合物是平均粒度约100微米或以下的晶体,此产品在干燥后水分含量失重不超过约5%,此产品的横截面区域至少约30%无横纹,此产物的横截面面积范围约在1-900平方毫米。本发明还涉及一种制剂,该制剂至少含有一种活性组分和所述可食用产品,或者至少含有一种活性组分和所述可食用产品的外壳及底物如核仁。外壳、核仁或二者都含有活性组分如药用活性组分。
Description
发明背景
发明领域
本发明涉及一种可食用产品,该产品本身可用于制备制剂或作为制剂外壳的组成成分,如组成外壳的药用组合物。本发明的制剂包含至少一种活性组分和该可食用产品本身,或者包括含有该可食用产品的外壳和至少部分被外壳包裹在内的底物或核仁。
背景信息
糖衣在糖果业中是众所周知的,通常用作包裹含果冻、巧克力、软糖等糖果核仁。
制备糖衣的常规方法包括硬淘洗和软淘洗技术,详细描述见Lachman,L.,Lieberman,H.A.,和Kanig,J.L.的《工业制药的原理与实践》(TheTheory and Practice of Industrial Pharmacy)第二版,Lea &Febiger,Philadelphia,1976,12章359-368页,W.P.P.Edwards的《糖果业科学》(The Science of Sugar Confectionery)第一版,The Royal Society ofChemistry,London,2000,8章95-100页,以及B.W.Minifie的《巧克力、可可与糖果业:科学与技术》(Chocolate,Cocoa,and Confectionery:Science andTechnology),AVI Publishing Company,Inc.1980年1月,19章608-613页。通过硬淘洗方法制备的外壳其晶体颗粒相对较小,约2-20微米,并且其颗粒直径分布范围相对较窄。硬淘洗制备的糖衣用光学显微镜作为横截面观察通数层。
软淘洗技术制备的外壳其晶体颗粒直径分布范围较宽,其中至少有一部分晶体的直径超过100微米。糖衣包裹的药片是大家所熟悉的,其典型组成及制备方法见Ceschel,G.C.等人的《片剂的糖衣包被》(Sugar Coating of Tablets),Bollettino Chimico Farmaceutico,119卷127-134页,1980,Schneider,H.;Speiser,P.的“Contibution to Sugar Coating Tablets”Pharmaceutica ActaHelvettae,43卷394-410页,以及Porter,S.C.的《片剂的包被:第一部分》(TabletCoating.Part 1),Drug Cosmet.Ind.,128卷,1981年5月,46-53及86-93页。这些制剂具有光滑的硬壳,该硬壳有保护作用,可以增加其物理和化学稳定性,改善其外观,还可以增加甜味。常规的糖衣制备方法较费时,故加工成本高。
因此,本发明的目的之一在于提供一种制备制剂的可食用外壳的方法,该方法省时、加工成本低。
本发明的另外一个目的是提供一种含这种可食用外壳制剂的制备方法。
本发明的另外一个目的在于提供一种可施加于底物如核仁的可食用产品。
本发明的另外一个目的在于提供一种含有本发明可食用外壳的制剂。
本发明的另外一个目的在于提供一种含有本发明可食用产品的制剂。
本领域技术人员通过本文对本发明的详细描述可以了解本发明的其他目的、特征及优点。
发明概述
本发明的可食用产品至少含有占产品总重量约50%的可结晶碳水化合物,其中至少约90%的可结晶碳水化合物是平均粒度约100微米或以下的晶体,该产品在干燥后水份含量失重不超过5%,该产物的横截面区域至少约30%无横纹,该产物的横截面面积约在1-900平方毫米范围内。
在另一个实施方式中,该产品含有约60%的可结晶碳水化合物。
在另一个实施方式中,该产品含有约75%的可结晶碳水化合物。
在另一个实施方式中,所述晶体的平均粒度小于约50微米。
在另一个实施方式中,该产品干燥后水份含量失重不超过约3%。
在另一个实施方式中,该产品干燥后水份含量失重不超过约1%。
在另一个实施方式中,该产品的横截面区域至少约50%无横纹。
在另一个实施方式中,该产品的横截面区域至少约80%无横纹。
在另一个实施方式中,该产品至少含有一种活性成分。
在一个实施方式中,本发明的可食用产品可以通过如下方法制备:(a)将流动性可结晶碳水化合物注射到模具腔中;(b)使该流动性可结晶碳水化合物在模具腔中硬化形成可食用产品;以及(c)将可食用产品从模具腔中取出。
本发明的制剂至少含有一种活性组分和可食用外壳,该外壳位于所述底物的至少一部分上,该外壳至少含有占外壳总重量约50%的可结晶碳水化合物,并且至少约90%的可结晶碳水化合物是平均粒度约100微米或以下的晶体,此外壳在干燥后水份不超过5%,此外壳的横截面区域至少约30%无横纹,此制剂的横截面面积约在1-900平方毫米范围内。
在另外一个实施方式中,此外壳的第一部分和第二部分在界面处相连接。
在另外一个实施方式中,此外壳的第一部分和第二部分外观不同。
在另外一个实施方式中,所述底物含有活性组分。
在另外一个实施方式中,所述底物是一种核仁,可食用外壳将此核仁包裹在其中。
在另外一个实施方式中,此外壳含有活性组分。
在另外一个实施方式中,所述核仁含有活性组分。
在另外一个实施方式中,此外壳和核仁各含有活性组分。
在另外一个实施方式中,所述活性组分在该制剂与液体介质接触时可溶解,所述活性组分的溶解符合USP规程,可使片剂所含活性组分立即释放。
在一个实施方式中,本发明的制剂可通过下列方法制备:(a)提供一种底物;(b)用可食用外壳包裹该底物的至少一部分,其中所述外壳至少含有占外壳总重量约50%的可结晶碳水化合物,并且至少约90%的可结晶碳水化合物是平均粒度约100微米或以下的晶体,外壳干燥后水份含量失重不超过约5%,外壳的横截面区域至少约30%无横纹,该制剂的横截面面积约在1-900平方毫米范围内。(c)所述底物或外壳或两者含有至少一种活性组分。
在一个实施方式中,本发明的制剂可通过下列方法制备:(a)将加热的流动性可结晶碳水化合物注入含有底物的模具腔中,使该流动性可结晶碳水化合物包裹模具腔内该底物的第一部分;(c)改变模具腔内的温度诱导包裹该底物的第一部分的流动性可结晶碳水化合物热激结晶;(d)打开模具腔并转动含底物的模具部分使与底物的第二部分接触;(e)关闭模具腔;(f)将加热的流动性可结晶碳水化合物注入模具腔中,使流动性可结晶碳水化合物包裹模具腔内该底物的第二部分;(g)迅速改变模具腔内的温度诱导包裹该底物的第二部分的流动性可结晶碳水化合物热激结晶;以及(h)将底物从模具腔中取出。
在另外一个实施方式中,本发明的制剂含有至少一种活性组分和至少占总重量约50%的可结晶碳水化合物,其中至少约90%的可结晶碳水化合物是平均粒度约100微米或以下的晶体,干燥后水份含量失重不超过约5%,此制剂的横截面区域至少约30%无横纹,此制剂的横截面面积约在1-900平方毫米范围内。
在另外一个实施方式中,此制剂含有约60%的可结晶碳水化合物。
在另一个实施方式中,此制剂含有约75%的可结晶碳水化合物。
在另一个实施方式中,所述晶体的平均粒度小于约50微米。
在另一个实施方式中,此制剂干燥后水份含量失重不超过约3%。
在另一个实施方式中,此制剂干燥后水份含量失重不超过约1%。
在另一个实施方式中,此制剂的横截面区域至少约50%无横纹。
在另一个实施方式中,此制剂的横截面区域至少约80%无横纹。
附图简要说明
图1A和1B描述用以前淘洗工艺制备的糖衣外壳横截面的显微照片。
图2A和2B分别描述实施例1所述制剂的横截面图和侧视图。
发明详述
本文所用的术语“制剂”适用于任何固体、半固体或液体组合物,该组合物含有特定的预先设定剂量的某种组分,如下面所描述的活性组分。适宜的制剂可以是药物转运系统,包括口服给药、颊部给药;或者输送矿物质、维生素或其他营养物质的组合物,口腔护理药物,食用香料等。本发明的优选制剂是固体,但是可以含有液体或半固体成分。在一个最佳实施方式中,此制剂是一种口服给药系统负责将药用活性组分运送到人的胃肠道中。
可用于本发明的适宜的活性组分包括药物、矿物质、维生素以及其他营养物质、口腔护理药物、食用香料及它们的混合物。适宜的药物包括镇痛药、抗炎药、治疗关节炎的药物、麻醉药、抗组胺药、镇咳药、抗生素、抗感染药、抗病毒药、抗凝剂、抗抑郁药、治疗糖尿病药物、止吐药、排气药、抗真菌药、抗惊厥药、食欲抑制剂、支气管扩张剂、心血管药物、中枢神经系统药物、中枢神经系统激动剂、减充血剂、利尿剂、祛痰药、胃肠药、治疗偏头疼药、运动疾病药物、黏液溶解剂、肌肉松弛剂、骨质疏松治疗药、多聚二甲硅氧烷、呼吸系统药物、催眠药、泌尿道药物及上述药物的混合物。
适宜的口腔护理剂包括呼吸清凉剂、洁齿剂、抗微生物药物、牙齿矿物质剂、牙齿腐蚀抑制剂、局麻药物、mucoprotectants等。
适宜的食用香料包括薄荷脑、薄荷、白苏香料、水果香料、巧克力、香草、泡泡糖香味剂、咖啡香料、甜酒香料及上述物质的组合等。
适宜的胃肠道药物例子包括抑酸剂如碳酸钙、氢氧化镁、氧化镁、碳酸镁、氢氧化铝、碳酸氢钠、二氢化铝碳酸钠;刺激性泻剂如比沙可啶、波希鼠李皮、丹蒽醌、番泻叶、酚酞、芦荟、海狸油、蓖麻油酸、脱氢胆酸及其上述物质混合物;H2受体拮抗剂如法莫替丁、雷尼替丁、西咪替丁、尼扎替丁;质子泵抑制剂如奥美拉唑或兰索拉唑;胃肠道细胞保护剂如sucraflate和米索前列醇;胃肠道动力药如prucalopride;抗幽门杆菌抗生素如克拉霉素、阿莫西林、四环素及甲硝唑;止泻药如苯乙哌啶和洛哌丁胺;溴环扁吡酯;止吐药如奥丹西隆;止痛药如氨基水杨酸。
在本发明的一个实施方式中,所述活性药物可选自比沙可啶、法莫替丁、雷尼替丁、西咪替丁、prucalopride、苯乙哌啶、洛哌丁胺、乳糖酶、氨基水杨酸、铋、抑酸剂、以及药学上可接受的盐、酯、异构体或上述物质的混合物。
在本发明的另外一个实施方式中,所述活性药物可选自对乙酰氨基酚、乙酰水杨酸、布洛芬、甲氧奈普酸、酮洛芬、氟布洛芬、二氯芬酸、环苯扎林、美洛昔康、rofecoxib、CELECOXIB、以及药用盐、酯、异构体或上述物质的混合物。
在本发明的另外一个实施方式中,所述活性药物可选自伪麻黄碱、苯丙醇胺、扑尔敏、右美沙芬、苯海拉明、阿司咪唑、特非那定、fexofenadine、氯雷他定、desloratadine、西替立嗪、上述物质的混合物、以及药学上可接受的盐、酯、异构体或其混合物。
适宜的聚二甲硅氧烷包括而不限于二甲聚硅氧烷和二甲硅油,这些在美国专利4,906,478、5,275,822和6,103,260中有描述,其内容都清楚地被纳入本文作为参考。本文所用的术语“二甲硅油”指一类较宽范围的多聚二甲硅氧烷,包括而不限于二甲硅油和二甲聚硅氧烷。
这些活性组分以有效治疗量包含在本制剂中,治疗有效量是在口服后可产生所需治疗效果的量,这不难由本领域技术人员确定。在确定此剂量时,如本领域所熟知的那样应考虑服用的具体活性组分、该活性组分的生物利用度、剂量方案、病人的年龄和体重以及其他需考虑的因素。在一个实施方式中,此制剂的核心至少含有约85%的该活性组分。
如果该活性组分有不良味道并且该制剂打算通过咀嚼或在咽下前能在口腔内崩解,那么如本领域所熟知的那样可在活性组分外包被上一层掩盖异味的包衣。合适的异味掩盖包衣的例子见美国专利4,851,226,5,075,114和5,489,436中描述。一些商品化的掩盖异味活性组分也可以采用,例如用乙基纤维素或其他聚合物包裹的对乙酰氨基酚粒子也可用于本发明中。团聚包裹的(Coaccervation-encapsulated)的对乙酰氨基酚可从Eurand America,Inc.(Vandalia,Ohio)或Circa Inc.(Dayton,Ohio)购买。
在一个实施方式中所述制剂含有一个压缩的核心,适用于压缩的赋形剂包括填料、粘合剂、崩解质、润滑剂、glidants等。
适宜的填料包括水溶性可压缩碳水化合物,如糖类,包括葡萄糖、蔗糖、麦芽糖和乳糖,糖-醇,包括D-甘露醇、山梨醇、maltitol、木糖醇,淀粉水解物,包括糊精、糊精麦芽糖复合剂等,水不溶性可塑性矫形材料如微晶纤维素或其他纤维素衍生物,水不溶性易碎折材料如磷酸氢钙、磷酸钙或其混合物。
适宜的粘合剂包括干粘合剂如聚乙烯吡咯烷酮、羟丙基甲基纤维素等;湿润粘合剂如水溶性聚合物,包括水状胶质如藻酸盐、琼脂、树胶、洋槐豆、角叉菜胶、焦油、阿拉伯树胶、黄蓍胶、果胶、苍耳烷、gellan、糊精-麦芽糖复合剂、半乳甘露聚糖、PUSSTULAN、昆布多糖、scleroglucan、阿拉伯树胶、菊糖、果胶、whelan、rhamsan、zooglan、甲醇化物、几丁质、环糊精、壳聚糖、聚乙烯吡咯烷酮、纤维素、淀粉等;以及上述物质的衍生物及混合物。
适宜的崩解剂包括淀粉羟乙酸钠、交联聚乙烯吡咯烷酮、交联羧甲纤维素、淀粉、微晶纤维素等。
适宜的润滑剂包括长链脂肪酸及其盐,如硬脂酸镁、硬脂酸、滑石及石蜡。
适宜的glidants包括胶体二氧化硅等类似物质。
本发明的制剂还可以含有药用佐剂,其中包括防腐剂、高强度甜料如天冬酰苯丙氨酸甲酯、乙酰舒泛钾、羟糖铝及糖精;香料、抗氧化剂、表面活性剂及着色剂。
所述活性组分或成分优选在接触液体如水、胃酸、肠液等时能溶解。在一个优选实施方式中,活性组分的溶解特征符合USP规程,可使片剂所含活性组分立即释放。在一个需要使活性组分能被吸收进入动物循环系统的实施方式中,此活性组分或成分优选在接触液体如水、胃酸、肠液等时能溶解。在一个实施方式中,此活性组分的溶解特征符合USP规程,可使片剂所含活性组分立即释放。例如,USP24规定对乙酰氨基酚片剂在pH5.8的磷酸缓冲液中,用USP装置2(桨板)50rpm搅拌,30分钟,至少要有80%的对乙酰氨基酚从该制剂中释放出来,对于布洛芬片剂,USP24规定在pH7.2的磷酸缓冲液中,用USP装置2(桨板)50rpm搅拌,60分钟内,至少要有80%的对乙酰氨基酚从该制剂中释放出来。见USP24,2000版,19-20及856页(1999)。在另一实施方式中,该活性组分的溶解特征经过修饰:即可控释、缓释、延长、滞后、长期、延迟释放等。
此制剂中活性组分或成分可以任何形式存在。例如,此活性组分可以在分子水平上分散开来,即溶化或溶解在制剂中,或者以颗粒的形式存在,因而可以是包衣的,也可以是不包衣的。如果活性组分以颗粒形式存在,典型颗粒(包衣或未包衣)的平均粒度约为1-2000微米。在一优选实施方式中此颗粒是平均粒度约1-300微米的晶体。在另外一个优选实施方式中,这些颗粒是平均粒度为约50-2000微米的粒子或小球,较好约50-1000微米,最好100-800微米。
本发明的可食用产品至少含有重量百分比约50%的可结晶碳水化合物,较好至少约60%,最好至少约75%。适宜的可结晶碳水化合物包括单糖和寡糖。己醛糖如阿洛糖的D和L异构体、阿蜀糖、葡萄糖、甘露糖、古洛糖、艾杜糖、半乳糖、太洛糖,己酮糖如果糖的D和L异构体,山梨糖及其羟化物如山梨糖醇和D-甘露醇都是本发明所包括的单糖。1,2-二糖如蔗糖和海藻糖,1,4-二糖如麦芽糖、乳糖和纤维二糖,1,6-二糖如龙胆二糖和蜜二糖,三糖如蜜三糖以及蔗糖的异构体如isomaltulose和羟化类似物都是本发明所包括的寡糖。降解二糖(如麦芽糖和乳糖)的其他氢化形式如麦芽醇和乳糖醇也是优选的。另外,优选戊醛糖的氢化形式如D核糖和L核糖、阿拉伯糖、木糖和来苏糖以及丁醛糖的氢化形式和赤藓糖和苏糖,例子分别为木糖醇和赤藓醇。
在一个实施方式中,可结晶碳水化合物可选自蔗糖、山梨糖醇、D-甘露醇、木糖醇、赤藓醇、麦芽醇、乳糖醇及其上述物质的衍生物和混合物。在一个实施方式中,可结晶碳水化合物是一种软糖,而在另一实施方式中,可结晶碳水化合物是糖玻璃,例如加热的糖和玉蜀黍糖浆混合物冷却后得到的产物。
可结晶碳水化合物应具有适宜的颗粒大小,优选的颗粒大小范围在约2-1000微米之间。在一个实施方式中,可结晶碳水化合物是软糖,其颗粒大小优选约2-35微米的。在另外的实施方式中,可结晶碳水化合物被加热至熔化状态,其颗粒大小为约2-1000微米或约1000-5000微米。
优选的可结晶碳水化合物其结晶形式至少约为总重量的90%,平均粒度约为100微米或更小,通常约为50微米或更小。
本发明的可食用产品水分含量通常应为干燥时失重小于约5%,较好的是小于3%,最好的是小于1%。干燥失重(L.O.D.)可通过如下方法测定:取一份可食用产品样品(一般约1-10克)分成约1-2平方毫米大小的小份或磨成粗粉。将已知量的制备样品放入一已配衡的铝制船形器皿中,放入装有无水硫酸钙或其他适宜干燥剂的干燥器中,直到重量恒定。原样品与干燥后样品重量的差异以水分含量百分数表示。另外也可以用USP的方法<731>测定干燥失重。
制备成本高时间长的淘洗技术现有方法所生产的糖包衣片剂和药物制剂特征是具有横纹模式,这类制剂或其糖衣壳的横截面可见此种横纹(见实施例图1A和1B)。这些特征性横纹是由以下多次重复步骤组成的淘洗过程的指征:a)施加糖浆,然后b)热空气干燥旋转包衣盘(如许多层精细结晶糖组成的盘)中的制剂翻滚床,每次干燥后加一次糖结晶形成一层。各层的厚度通常在约0.01-0.013毫米范围内。
另外,本发明的可食用产品可以很方便地通过熔铸过程直接施加到所述物用作糖外壳,在5分钟或更短时间内,如60秒或更短、30秒或更短、10秒或更短、在某些特定实施方式中1秒或更短的时间内,生成一层完整的匀质层。因此,本发明的可食用产品至少约30%的横截面面积是无横纹,较好至少约50%,最好至少约80%无横纹。本文所述的“无横纹”指当在放大及灯光条件下观看时,其外观和糖基质的内部结构均匀一致。例如,用光学显微镜放大50-400倍观察时此产品的横截面无横纹并且折光特性均一。
本发明的可食用产品或可食用外壳所具有的横截面面积约在约1-900平方毫米范围内,较好约25-400平方毫米,最好约50-100平方毫米范围内。
图1A和1B显示用以前的淘洗技术制备的包衣组合物,具有横纹,与本发明所制备的产物不同。图1A显示用以前的DRIXORAL技术12小时制备出的片剂(从Schering Plough Inc.购买到)的横截面的显微照片。图1B显示用以前的ADVIL技术制备出的片剂(从Wyeth Inc.购买到)的横截面显微照片。这两种以前技术的产品用50-400倍光学显微镜观察时都可以清楚地看到横纹。
本发明的可食用产品可用下列方法制备:(a)将流动性可结晶碳水化合物注入模具腔中;(b)使该流动性可结晶碳水化合物在模具的腔中硬化成为可食用产品;(c)将该可食用产品从模具腔中取出。(d)任选将该可食用产品干燥;以及(e)任选将该可食用产品的表面抛光或磨光。在一个实施方式中,该方法还包括诱导模具腔内的流动性结晶碳水化合物热激结晶,使其在模具腔内硬化。
另外一个实施方式中的方法,包括使该流动性可结晶碳水化合物冷却至其玻璃化转化温度以下,使其在模具腔内形成含有不定形糖玻璃的非流动性结块。
本文所述的“流动性可结晶碳水化合物”指含有可结晶碳水化合物的可流动块,例如分散在饱和碳水化合物溶液中的碳水化合物结晶,即不定形玻璃形式的软碳水化合物或熔化的碳水化合物。本文所述的“硬化”指使块状物体不流动。
本发明制备具有外壳包裹所述核仁或底物至少一部分的可食用产品的一种优选方法包括:(a)将加热的流动性可结晶碳水化合物注入含有所述物质的模具腔中,使该流动性可结晶碳水化合物包裹模具腔内底物的第一部分;(b)迅速改变模具腔内的温度诱导包裹底物第一部分的流动性可结晶碳水化合物热激结晶;(c)打开模具腔并转动含底物的模具部分暴露该底物的第二部分;(d)关闭模具腔;(e)将加热的流动性可结晶碳水化合物注入模具腔中,从而使流动性可结晶碳水化合物包裹模具腔内该底物的第二部分;(f)迅速改变模具腔内的温度诱导包裹底物第二部分的流动性可结晶碳水化合物热激结晶;以及(g)将已包衣的底物从模具腔中取出。流动性可结晶碳水化合物可在加热进料罐中加热。
在一个具体实施方式中,所述外壳包括毗邻的两部分,因而形成一层完全包裹底物或核心的外壳。任选地可干燥此外壳,和任选地将外壳放在旋转盘中完成抛光或磨光。
一种适合制备流动性可结晶碳水化合物的方法是将可结晶碳水化合物与足量的水混合,任选地在非结晶碳水化合物中混合,和任选地将碳水化合物与水的化合物加热,以得到所需要的固体成分。在某些实施方式中,可将可结晶碳水化合物以晶体形式加入加热的碳水化合物和水的混合物中。加热可结晶碳水化合物的适宜温度约100-165℃。在某些实施方式中,可将可结晶碳水化合物加热至其熔点温度之上,例如约145-165℃。在这些实施方式中,流动性可结晶碳水化合物是玻璃形式。在另外一些特定实施方式中,可将可结晶碳水化合物加热至其熔点温度之下,例如约100-130℃。在这些实施方式中,此流动性可结晶碳水化合物是软糖形式。
在某些实施方式中,将可结晶碳水化合物与非结晶碳水化合物混合在一起加热,二者比例约为50∶50-90∶10。在某些流动性可结晶碳水化合物是玻璃形式的实施方式中,可结晶碳水化合物与非结晶碳水化合物混合的优选比例约50∶50-69∶41。在某些流动性可结晶碳水化合物是以软糖形式的实施方式中,可结晶碳水化合物与非结晶碳水化合物混合的优选比例是约70∶30-90∶10。在这些实施方式中,此流动性可结晶碳水化合物最好在冷却过程中加以搅拌。
在一个具体实施方式中,此流动性可结晶碳水化合物是亚稳定性玻璃形式,不搅拌冷却约1-60分钟后发生结晶。在这个实施方式中,可结晶碳水化合物与非结晶碳水化合物混合的比例约65∶35-75∶25之间。为了诱导可结晶碳水化合物结晶,可以另外将约占可结晶碳水化合物重量1%的结晶形式的可结晶碳水化合物加到已加热的碳水化合物和水的混合物中。
合适的保持加热的流动性可结晶碳水化合物的温度为约80-98℃,通过从此较高温度快速改变铸模腔温度,进行铸模腔温度的快速改变至适当的“冷循环”温度,以激发该可结晶碳水化合物结晶。适合的冷循环温度范围约为-10℃至60℃,优选-10℃至25℃。将该动性可结晶碳水化合物冷却至其玻璃转化温度以下,以形成含不定形糖-玻璃的合适铸模温度范围为约0-80℃。
在一个实施方式中,本发明的制剂是一种含有至少一种活性组分和本发明的可食用产品的固体制剂。
在另外一个实施方式中,本发明的制剂至少含有一种活性组分、一种用本发明可食用产品制成的可食用外壳和作为核仁的底物,可食用外壳位于底物上或至少包裹该底物的一部分。本文所述的术语“底物”指一种表面或一种位于下面的支持物,其上有其他材料存在,术语“核仁”指一种材料,如被另外某些材料如外壳所包围或包裹的物质。外壳、核仁、底物或它们的组合物可以含有活性组分,如药用活性组分。
在一个实施方式中,可食用外壳至少包裹该底物的一部分。该底物可以是任何可食用材料,优选固体形态的如胶囊、片剂、小丸、菱形、小球、颗粒、粉末、太妃糖、奶油杏仁糖、焦糖、巧克力等;半固体形态的如凝胶、胶冻、乳酪、软糖等;以及液体形态的如悬液、溶液、糖浆、乳剂等。
在另一实施方式中,所述底物是一种被压制或铸造的核仁。此核仁可任选地部分被压制的、铸造的或喷雾形成的亚包衣层所覆盖。在本发明的一个优选实施方式中,此核仁获自压制粉末。该粉末优选含有一种活性组分,还任选地含各种赋形剂,如粘合剂、崩解剂、润滑剂、填料、glidants等,这些物质是常规的或是有药用特性或无药用特性的其它颗粒材料,如片剂的无活性安慰剂混合物,糖果混合物等。在一个实施方式中,此核仁含有活性组分、粉末状腊(如虫胶腊、微晶体腊、聚乙二醇等),和任选的崩解剂和润滑剂,在待批美国专利申请09/966,493的4-11页有其详细描述,本文已纳入作为参考。
此核仁可以是不同形状,例如在一个实施方式中此核仁可以是截短锥体形状。在另一些实施方式中,此核仁可以是多角体,如立方体、锥体、棱形等;或可以是具有某些非平面的几何立体形状,如锥体、圆柱体、球形、隆突形等。可用于本发明的示范性核形状包括由压制工具形状的形成的片剂形状,见“TheElizabeth Companies Tablet Design Training Manual”(Elizabeth Carbide DieCo.,Inc.,P7(Mckeesport,PA.),本文已纳入作为参考。)的描述,其具体形状如下(片剂的形状与压制工具的形状正好相反):
1.浅凹形
2.标准凹形
3.深凹形
4.极深凹形
5.修饰的球面凹形
6.标准对开凹形
7.标准双对开凹形
8.标准欧洲对开凹形
9.标准部分对开凹形
10.双面幅射形
11.斜角凹形
12.平面形
13.平面斜角边缘形(F.F.B.E.).
14.F.F.B.E.Bisect.
15.F.F.B.E.Double Bisect.
16.环形
17.浅凹形
18.椭圆形
19.卵形
20.胶囊
21.长方形
22.正方形
23.三角形
24.六边形
25.五角形
26.八角形
27.钻石形
28.箭头形
29.弹头形
30.桶形
31.半月形
32.盾牌形
33.心形
34.杏仁形
35.碟形House/Home Plate.
36.平行四边形
37.小多角形
38.8形/杠铃形
39.蝴蝶结形
40.不规则三角形
在本发明的另外一个实施方式中,本发明的制剂含有粉末状混合物制成的核心,其平均粒度约50-500微米,例如约100-500微米。
在本发明的另外一个实施方式中,此核由基本上不含水溶性多聚粘合剂及水合聚合物的粉末直接压制成片剂。该组合物的优点是保持了快速释放溶解的特点、处理过程简化、材料成本降低、并且使制剂保持了最佳的物理和化学稳定性。
在一个优选实施方式中,此核仁通过压制方法制备,压制设备见美国待批专利申请09/966,509第16-27页的详细描述,本文已纳入作为参考。具体地说该核仁用一种旋转压制模块制成,该模块包括填充区、插入区、压缩区、排出区和清洗区,该模块位于如美国专利申请09/966,509中图6所示的双排铸模结构的机器上。压制模块的铸模优选用真空泵帮助填充,在每个铸模上或附近装有一个过滤器。压制模块的清洗区包括一个任选的粉末回收系统以从过滤器回收剩余粉末,并将粉末送回铸模中。
此核仁或者可以用热设定成型方法和设备制备,见美国专利申请09/966,450第57-63页的详细描述,本文已纳入作为参考。在这个实施方式中,此核仁通过将可流动形式的起始材料注入铸模槽中形成。起始材料优选含有活性组分的,热设定材料的温度优选在其熔点温度之上但在该活性组分的降解温度之下。起始材料在铸模室中被冷却固化成为成型的核(即具有铸模形状的核)。
根据本方法,起始材料必须是可流动形式的。例如可以含有悬浮于熔化基质如聚合物基质中的固体颗粒。起始材料可以是完全熔化的或是浆糊形式。起始材料可以含有溶解于熔化材料中的活性组分。另外,起始材料可以通过将固体溶于溶剂中制备,然后在铸模后将溶剂从起始材料中蒸发掉。
此核仁也可以用热循环铸模方法和设备制备,见美国专利申请09/966,497第27-51页的详细描述,本文已纳入作为参考。在美国专利申请09/966,497描述的热循环铸模方法和设备中,采用了具有图3所示通用结构的热循环铸模模具。此热循环铸模模具200包含一个转头202,在其周围有一组铸模单元204。此热循环铸模模具包括一个储存槽206(见图4),用于盛装可流动材料以制备此核仁。另外,此热循环铸模模具还装有一种温度控制系统用于快速加热和冷却铸模单元。图55和图56描述了这样一种温度控制系统600。
在本发明的另外一个实施方式中,所述核仁含有一个或多个植入物,该植入物可以制成任何形状或尺寸。例如可以是不规则形状的植入物,具有一个以上对称轴形状。该植入物也可以是圆柱形。在一个优选实施方式中,该植入物用待批美国专利申请09/966,450第57-63页所描述的方法和设备通过本文所述的热设定铸模过程制备。制备植入物的起始材料可以含有任何需要的掺入到成形产物中的可食用材料,包括活性组分如前述与核仁有关的那些活性组分、营养物质、维生素、矿物质、香料、甜料等。
起始材料优选包含一种活性组分和一种热设定材料。此热设定材料可以是任何可食用材料,在约37-120℃之间可流动,在约0-35℃之间是固体。优选的热设定材料包括水溶性聚合物如聚烷基甘油、氧化聚乙烯及其衍生物、蔗糖酯;脂肪类物质如可可脂、氢化植物油如棕榈仁油、棉花子油、向日葵油和大豆油;甘油酯、甘油二酯及甘油三酯、磷酸酯、蜡类如carnuba wax、鲸蜡、蜂蜡、candelillawax、虫胶、微晶体蜡及石蜡;含脂混合物如巧克力;无定型玻璃状的糖如用于制作硬糖果的糖、过饱和糖溶液如用于制作软糖的糖溶液;低水分聚合物溶液如水分含量达到约30%的明胶和其他水状胶体的混合物,例如用于制作gummi甜食的那些物质。在一个特别优选的实施方式中,此热设定材料是一种水溶性聚合物如聚乙烯甘油。
在本发明的一个实施方式中,植入物的平均直径约为100-1000微米。在本发明的另外一个实施方式中,植入物的平均直径或厚度约为此核仁直径或厚度的10%-90%。本发明的另外一个实施方式中此核仁含有多个植入物。
本发明的外壳可以通过注射使可食用产品成型而制备,优点可以最大程度地降低或消除直接压制填料-粘合剂的需要,如微晶体纤维素、喷雾干燥的乳糖、矿物质盐如磷酸钙、结晶糖如蔗糖、右旋糖等。这些材料的缺点是可破坏外壳的透明度和稳定性。本发明的外壳优选含有直接压制的填料-粘合剂含量少于约10%、少于1%或少于0.1%。因此本发明的外壳是一种压制包衣壳改进型,如WO 00/18447描述的那样,其直接压制的填料-粘合剂含量至少约占30%。
在本发明的一个优选实施方式中,可采用待批美国专利申请09/966,497第27-51页所描述的热循环方法和设备制备,将加热的可流动化可结晶碳水化合物形式的外壳施加到核仁上。在这个实施方式中,用热循环铸模模具制备的加热的可流动可结晶碳水化合物具有本文附图3所示的通用结构。热循环铸模模具200包含一个转头202,在其周围有一组铸模单元204。此热循环铸模模具包括一个储存槽206(见图4),用于盛装加热的可流动可结晶碳水化合物。另外,此热循环铸模模具还装有一温度控制系统用于快速加热和冷却铸模单元。图55和图56描述了这样一种温度控制系统600。
优选此热循环铸模模具具有如待批美国专利申请09/966,497中图28A所示的类型,含有一系列的铸模单元204。如图28C所示,铸模单元204包括上位铸模组件214、可旋转的中间铸模组件212和下位铸模组件210。将核仁被不断地输送到铸模组件中,铸模组件随后闭合包裹核仁。可结晶碳水化合物在储存槽206中被加热成可流动的状态,然后注入到闭合铸模组件组成的铸模腔中。降低该流动性可结晶碳水化合物的温度使其硬化。打开铸模组件吐出已包衣的核仁。包衣分两步进行,核的两半通过中间铸模组件的旋转分别包衣,如待批美国专利申请09/966,497图28B中的流程图所示。
在本发明的一个实施方式中,只有所述底物或核仁含有一种或多种活性组分。在本发明的另外一个实施方式中,只有所述外壳含有一种或多种活性组分。而在本发明的其他实施方式中,只有所述植入物含有一种或多种活性组分。本发明还有一些实施方式中仁核和外壳都含有一种或多种活性组分。在本发明的另外一些实施方式中,一个或多个核仁、外壳或植入物都含有一种或多种活性组分。
在另外一个实施方式中,本发明的制剂还可以含有一种底物或核仁,其含有的组合物与外壳的不同。在另外一个实施方式中,外壳材料也可具有与该制剂的底物或外壳的功能。另外一个实施方式中,此制剂还可含有一种位于外壳表面的糖衣。
在另外一个实施方式中,此外壳分含有第一部分和第二部分,二者在界面处相连。
在另外一个实施方式中,此外壳的第一部分和第二部分外观彼此不同。例如第一部分和第二部分的大小、形状、局部结构或其他几何特征、色彩、色调、透明度及光泽不同。
在另外一个实施方式中,本发明的制剂通过如下方法制备,该方法包括提供一种底物以及该底物的至少一部分用可食用外壳包裹。此外壳至少含有占外壳总重量约50%的可结晶碳水化合物。可结晶碳水化合物中至少约90%的是晶体,其平均粒度小于约100微米,外壳的水分含量干燥失重时不超过5%,较好不超过3%,最好不超过1%。外壳的横截面区域至少约30%无横纹,较好至少约50%,最好的是至少约80%无横纹,此制剂的横截面面积约约1-900平方毫米,优选约25-400平方毫米。
本发明将用以下面的实施例进一步说明,但这些实施例不意味着对本发明的任何限定。
实施例1
根据本发明按照下述方式制备一批铸模对乙酰氨基酚片剂:
A.软糖的制备(90%固体):将软糖(Amerfond,购自Domino Foods)置于具有恒温控制的行星状混合盘中,室温下,混合盘配置有一浆叶,边缓慢混合边加入表1所设定浓度的水。混合持续进行直到软糖变得光滑均一。
表1
组分 | % | mg/片 | gms/批 |
Amerfond | 90.00 | 353.09 | 202.84 |
纯水USP | 10.00 | 39.23 | 22.54 |
总计 | 100.00 | 392.32 | 225.38 |
B.Bob糖浆的制备:取一个两夸脱的不粘果酱盘和一个软膏刀,将蔗糖、玉蜀黍糖浆和水按照表2所示的浓度加到盘中,记录毛重。将混合物在火上烘煮成87%的固体(约115℃)。
表2
组分 | % | mg/片 | gms/批 |
蔗糖 | 81.00 | 989.85 | 568.64 |
玉蜀黍糖浆42D.E.(80%) | 7.50 | 91.65 | 52.65 |
纯水 | 11.50 | 140.54 | 80.73 |
总计 | 100.00 | 1222.04 | 702.02 |
C.终产品:将转化糖、水和香料以表3所示浓度加到放置软糖(A)的行星状混合盘中,缓慢混合直到均一。混合盘用锡箔覆盖加热到90℃。然后加入煮好的″bob″糖浆(B),充分混合。加入对乙酰氨基酚再混合直到光滑均一。加入少量水以维持自由流动状态。
表3
组分 | % | mg/片 | gms/批 |
软糖(90%固体) | 17.77 | 392.32 | 225.38 |
“bob″(87%固体) | 55.4 | 1222.04 | 702.02 |
对乙酰氨基酚 | 22.64 | 500.00 | 287.24 |
纯水 | 3.69 | 81.50 | 46.82 |
转化糖 | 0.11 | 2.39 | 1.373 |
Sucralose | 0.07 | 1.49 | 0.856 |
香料 | 0.38 | 8.50 | 4.883 |
总计 | 100.00 | 2208.24 | 1268.57 |
最终的混合物在室温下置于双片橡胶或硅模具中。模具加满后立刻使混合物充分硬化从模具中取出。完全干燥产品并使其进一步硬化。
将铸成的核心转移到包衣锅中用绿色外壳包被观察效果。图2A和图2B显示铸成的制剂横截面面及侧视图,该制剂具有一个铸成的核仁20和绿色的外壳22。实施例1的制剂不含有任何条纹。
实施例2
按照本发明所制备的一批糖衣固体制剂。下表4显示本发明的软糖混合物用作制剂的外壳:
表4
组分 | 商品名 | 供应商 | mg/片 | 理论Kg/批 |
软糖(90%固体) | Amerfond | Domino Sugar | 196 | 83.40 |
Bob糖浆(87%固体) | 611 | 260.00 | ||
纯水 | 42 | 17.87 | ||
转化糖溶液(72%固体) | 1 | 0.43 | ||
总计 | 850 | 361.7 |
将干的软糖置于行星状混合盘中,用一浆叶缓慢混合,加入占总重量10%的纯水,直到软糖变得光滑均一。然后将转化糖溶液和纯水与软糖混合完全。将烧煮颗粒状蔗糖、42DE玉蜀黍糖浆和水(75∶7∶18%w/w)的混合物成为87%固体或115℃得到的Bob糖浆加入到软糖/转化糖混合物中混合直至均一(约2分钟)。
将软糖混合物转移到加热的储存槽中。此储存槽见待批美国专利申请09/966,497第27-51页所描述,在其附图4中标记为206。储存槽内的软糖混合物温度维持在90-95℃,用一机动混合浆叶(未在图中标出)缓慢混合。将储存槽盖好,加压至约150psi或至足够的压力使温热的软糖混合物流到热循环铸模模具中,如待批美国专利申请09/966,497所述。
通过待批美国专利申请09/966,509第16-27页所述的压制方法和设备制备核仁,本文已纳入作为参考。具体说,用一种旋转压制模块制备核仁,该模块包括填充区、插入区、压制区、排出区和清洗区,该模块位于带有美国专利申请09/966,509图6所示的双排铸模结构的装置上。此压制模块的铸模优选在真空泵的帮助下填充,在每个铸模中或附近有一个过滤器。该压制模块的清洗区包括一任选的粉末回收系统以从过滤器回收剩余粉末,并将粉末送回铸模中。核仁被一个转移装置接收,该装置的结构见美国专利申请09/966,414中图3所述,标示为300,本文已纳入作为参考。该转移装置包含一组转移单元304,304以悬臂方式固定在带子312上,如美国专利申请09/966,414中图68和图69所示。此转移装置与连接的压制模具和热循环铸模模具同步旋转和操作。转移单元304包括定位器330以在这些核仁绕转移装置转动时抓住核仁。
该转移装置将核仁转移到热循环铸模模具,铸模模具将软糖混合物施加到核上。该热循环铸模模具类型见待批美国专利申请09/966,497中图28A所示。热循环铸模模具的铸模单元204含有如图28C所示的上位铸模组件214、可旋转的中间铸模组件212和下位铸模组件210。核仁被不断地输送到铸模组件中,随后闭关铸模组件包住核仁。匀速冷却铸模组件到约10℃。然后将加热的流动性软糖混合物填入铸模组件中。软糖混合物是一种过饱和糖溶液,受激发生结晶化成为硬固体物包裹压制核仁。打开铸模组件排出已包衣的核仁。包衣分两步进行,核仁的两半通过中间铸模组件的旋转分别包衣,见美国专利申请09/966,497图28B中的流程图所示。
一旦软糖混合物作为外壳充分包裹核仁后(约1-60秒),打开铸模组件,使处于加工中的制剂排出热循环铸模模具,运送到干燥器中使外壳完全硬化,并去除残余水分,得到制剂终产品。
干燥后,已包衣的核可任选地在包衣盘上添加色彩、香料、光泽或使其光滑完成加工。
实施例3
按照本发明采用下表5所示的剂量制备的一批固体制剂:
表5
组分 | 商品名 | 供应商 | mg/片 | 理论Kg/批 |
软糖(90%固体) | Amerfond | Domino Sugar | 196 | 83.40 |
Bob糖浆(87%固体) | 611 | 260.00 | ||
对乙酰氨基酚 | Malincrodt | 325 | 138.30 | |
纯水 | 42 | 17.87 | ||
转化糖溶液(72%固体) | 1 | 0.43 | ||
总计 | 1175 | 500.0 |
将干的软糖置于行星状混合盘中,用一浆叶缓慢混合,加入占总重量10%的纯水,直到软糖变得光滑均一。然后将转化糖溶液和纯水与软糖合并完全混合。将颗粒状蔗糖、42DE玉蜀黍糖浆和水(75∶7∶18%w/w)的混合物烧煮成为87%固体或115℃而得到的Bob糖浆加入到软糖/转化糖混合物中混匀至均一(约2分钟)。将此混合物的温度保持在90-95℃,加入对乙酰氨基酚,混合均匀。
将对乙酰氨基酚软糖混合物转移到加热的储存槽中。此储存槽见待批美国专利申请09/966,497第27-51页所述,在附图4中标记为206。将储存槽内的对乙酰氨基酚软糖混合物维持在90-95℃,用一机动混合浆叶(未在图中标出)缓慢搅拌。将储存槽206盖好,加压至约150psi或至足够的压力使对乙酰氨基酚/软糖混合物流到热循环铸模模具中,此模具的具体结构见待批美国专利申请09/966,497的图26A所述。该热循环铸模模具包括中心铸模组件212和上位铸模组件214,如图26C所描述,二者相配共同形成铸模腔。转子202旋转时,相对的中心铸模组件及上位铸模组件关闭。将铸模组件匀速地冷却至约10℃。将对乙酰氨基酚/软糖混合物注入到模具腔中。附着对乙酰氨基酚/软糖混合物进入模具腔,过饱和糖溶液受激而结晶成为包含有悬浮对乙酰氨基酚晶体的硬固体物。一旦此固体物形成(约1-60秒),打开铸模组件,使已制成的制剂排出热循环铸模模具,运送到干燥器中完全硬化。
干燥后,任选地将该制剂在包被盘上添加色彩、香料、光泽或使其光滑完成加工。
尽管本发明已参考具体实施方式进行了说明,但本领域技术人员懂得,可进行各种改动或修改但它们均属于本发明的范围之内。
Claims (30)
1.一种可食用产品,其特征在于,该产品含有至少占产品总重量约50%的可结晶碳水化合物,其中至少约90%的可结晶碳水化合物是平均粒度约100微米或以下的晶体,该产品干燥后水份含量失重不超过5%,该产品的横截面区域至少约30%无横纹,该产品的横截面面积约在1-900平方毫米范围内。
2.如权利要求1所述的产品,其特征在于,该产品中含有约60%的可结晶碳水化合物。
3.如权利要求2所述的产品,其特征在于,该产品中含有约75%的可结晶碳水化合物。
4.如权利要求1所述的产品,其特征在于,该产品中的晶体平均粒度小于约50微米。
5.如权利要求1所述的产品,其特征在于,该产品干燥后水份含量丢失不超过约3%。
6.如权利要求5所述的产品,其特征在于,该产品干燥后水份含量丢失不超过约1%。
7.如权利要求1所述的产品,其特征在于,其中该产品的横截面面积至少约50%无横纹。
8.如权利要求1所述的产品,其特征在于,其中该产品的横截面面积至少约80%无横纹。
9.如权利要求1所述的产品,其特征在于,该产品至少含有一种活性组分。
10.一种制备可食用产品的方法,其特征在于,该方法包括:(a)流动性可结晶碳水化合物注射到模具腔中;(b)使流动性可结晶碳水化合物在模具腔中硬化成为可食用产品;以及(c)将可食用产品从模具腔中取出。
11.一种可食用产品,由包括下列步骤的方法制备:a)将流动性可结晶碳水化合物注入铸模腔中;b)使铸模腔中的流动性可结晶碳水化合物硬化成为可食用产品;和c)从铸模膜中取出该可食用产品。
12.一种制剂,包含至少一种活性组分和位于底物至少一部分上的可食用外壳,其中该外壳至少含有占其重量约50%的可结晶碳水化合物,并且重量至少约90%的可结晶碳水化合物是平均粒度约100微米或以下的晶体,该外壳干燥后水份含量失重不超过5%,该外壳的横截面区域至少约30%无横纹,该制剂的横截面面积约在1-900平方毫米范围。
13.如权利要求12所述的制剂,其特征在于,外壳的第一部分和第二部分在界面处相连接。
14.如权利要求13所述的制剂,其特征在于,外壳的第一部分和第二部分外观可不同。
15.如权利要求12所述的制剂,其特征在于,所述底物含有活性组分。
16.如权利要求12所述的制剂,其特征在于,所述底物是一个核心,可食用外壳将该核心包裹其中。
17.如权利要求12所述的制剂,其特征在于,所述外壳含有活性组分。
18.如权利要求16所述的制剂,其特征在于,所述核心含有活性组分。
19.如权利要求16所述的制剂,其特征在于,外壳和核各含有一种活性组分。
20.如权利要求17-19中任一项所述的制剂,其特征在于,所述活性组分在该制剂接触液体介质时可溶解,活性组分的溶解符合USP规程,可使片剂所含活性组分立即释放。
21.一种制剂,由包括下列步骤的方法制备:
(a)提供底物;
(b)用可食用外壳包裹该底物的至少一部分,其中所述外壳至少含有占外壳总重量约50%的可结晶碳水化合物,并且重量至少约90%的可结晶碳水化合物是平均粒度约100微米或以下的晶体,所述外壳干燥后水份含量失重不超过5%,外壳的横截面区域至少约30%无横纹,所述制剂的横截面面积约在1-900平方毫米范围内;以及
(c)所述底物或外壳或两者都含有至少一种活性组分。
22.一种制备制剂的方法,该方法包括:(a)将加热的流动性可结晶碳水化合物注入含有底物模具腔中,使该流动性可结晶碳水化合物包裹模具腔内该底物的的第一部分;(c)改变模具腔内的温度诱导包裹该底物第一部分的流动性可结晶碳水化合物热激结晶;(d)打开模具腔并转动含该底物的模具部分使底物的第二部分暴露;(e)关闭模具腔;(f)将加热的流动性可结晶碳水化合物注入模具腔中,使该流动性可结晶碳水化合物包裹模具腔内该底物的第二部分;(g)迅速改变模具腔内的温度诱导包裹该底物第二部分的流动性可结晶碳水化合物热激结晶;以及(h)将所述底物从模具腔中取出。
23.一种制剂,包含至少一种活性组分和至少占总重量约50%的可结晶碳水化合物,其中至少约90%的可结晶碳水化合物是平均粒度约100微米或以下的晶体,该制剂干燥后水份含量失重不超过5%,该制剂横截面区域至少约30%无横纹,该制剂的横截面面积约约在1-900平方毫米范围内。
24.如权利要求23所述的制剂,其特征在于,该制剂中含有约60%的可结晶碳水化合物。
25.如权利要求24所述的制剂,其特征在于,该制剂中含有约75%的可结晶碳水化合物。
26.如权利要求23所述的制剂,其特征在于,该制剂中晶体的平均粒度小于约50微米。
27.如权利要求23所述的制剂,其特征在于,该制剂干燥后水份含量失重不超过约3%。
28.如权利要求26所述的制剂,其特征在于,该制剂干燥后水份含量失重不超过约1%。
29.如权利要求23所述的制剂,其特征在于,该制剂的横截面区域至少约50%无横纹。
30.如权利要求23所述的制剂,其特征在于,该制剂的横截面区域至少约80%无横纹。
Applications Claiming Priority (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/966,509 US6767200B2 (en) | 2001-09-28 | 2001-09-28 | Systems, methods and apparatuses for manufacturing dosage forms |
US09/966,509 | 2001-09-28 | ||
US09/966,450 | 2001-09-28 | ||
US09/966,497 | 2001-09-28 | ||
US09/966,497 US7122143B2 (en) | 2001-09-28 | 2001-09-28 | Methods for manufacturing dosage forms |
US09/967,414 US6742646B2 (en) | 2001-09-28 | 2001-09-28 | Systems, methods and apparatuses for manufacturing dosage forms |
US09/966,939 US6837696B2 (en) | 2001-09-28 | 2001-09-28 | Apparatus for manufacturing dosage forms |
US09/966,450 US6982094B2 (en) | 2001-09-28 | 2001-09-28 | Systems, methods and apparatuses for manufacturing dosage forms |
US09/967,414 | 2001-09-28 | ||
US09/966,939 | 2001-09-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN1596100A true CN1596100A (zh) | 2005-03-16 |
Family
ID=27542311
Family Applications (10)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNA028235401A Pending CN1596102A (zh) | 2001-09-28 | 2002-09-28 | 调节释放剂型 |
CNB028233727A Expired - Fee Related CN100364515C (zh) | 2001-09-28 | 2002-09-28 | 具有不同形状内核和外壳的剂型 |
CNA028236386A Pending CN1596100A (zh) | 2001-09-28 | 2002-09-28 | 可食用组合物及含可食用外壳的制剂 |
CNA028233476A Pending CN1592610A (zh) | 2001-09-28 | 2002-09-28 | 改良的释放剂型 |
CNA028233611A Pending CN1638740A (zh) | 2001-09-28 | 2002-09-28 | 释出得到修饰的剂型 |
CNA028233441A Pending CN1592611A (zh) | 2001-09-28 | 2002-09-28 | 改良释放的剂型 |
CNA028236505A Pending CN1596101A (zh) | 2001-09-28 | 2002-09-28 | 含有糖果组分的剂型 |
CNA028233549A Pending CN1592612A (zh) | 2001-09-28 | 2002-09-28 | 有内核和外壳的剂型 |
CNA028236416A Pending CN1596104A (zh) | 2001-09-28 | 2002-09-28 | 改进的释放剂型 |
CNB028234308A Expired - Fee Related CN100408029C (zh) | 2001-09-28 | 2002-09-28 | 有镶嵌部分的组合剂型 |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNA028235401A Pending CN1596102A (zh) | 2001-09-28 | 2002-09-28 | 调节释放剂型 |
CNB028233727A Expired - Fee Related CN100364515C (zh) | 2001-09-28 | 2002-09-28 | 具有不同形状内核和外壳的剂型 |
Family Applications After (7)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNA028233476A Pending CN1592610A (zh) | 2001-09-28 | 2002-09-28 | 改良的释放剂型 |
CNA028233611A Pending CN1638740A (zh) | 2001-09-28 | 2002-09-28 | 释出得到修饰的剂型 |
CNA028233441A Pending CN1592611A (zh) | 2001-09-28 | 2002-09-28 | 改良释放的剂型 |
CNA028236505A Pending CN1596101A (zh) | 2001-09-28 | 2002-09-28 | 含有糖果组分的剂型 |
CNA028233549A Pending CN1592612A (zh) | 2001-09-28 | 2002-09-28 | 有内核和外壳的剂型 |
CNA028236416A Pending CN1596104A (zh) | 2001-09-28 | 2002-09-28 | 改进的释放剂型 |
CNB028234308A Expired - Fee Related CN100408029C (zh) | 2001-09-28 | 2002-09-28 | 有镶嵌部分的组合剂型 |
Country Status (20)
Country | Link |
---|---|
US (15) | US8545887B2 (zh) |
EP (12) | EP1429742B1 (zh) |
JP (11) | JP2005508325A (zh) |
KR (11) | KR20040045034A (zh) |
CN (10) | CN1596102A (zh) |
AT (4) | ATE476957T1 (zh) |
AU (1) | AU2002330164A1 (zh) |
BR (11) | BR0206062A (zh) |
CA (12) | CA2461684A1 (zh) |
CO (1) | CO5570655A2 (zh) |
DE (4) | DE60239945D1 (zh) |
ES (3) | ES2311073T3 (zh) |
HK (1) | HK1072902A1 (zh) |
HU (1) | HUP0401686A3 (zh) |
MX (12) | MXPA04002978A (zh) |
NO (4) | NO20032364L (zh) |
NZ (3) | NZ532097A (zh) |
PL (1) | PL369134A1 (zh) |
PT (1) | PT1429738E (zh) |
WO (12) | WO2003026616A1 (zh) |
Families Citing this family (314)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8071128B2 (en) | 1996-06-14 | 2011-12-06 | Kyowa Hakko Kirin Co., Ltd. | Intrabuccally rapidly disintegrating tablet and a production method of the tablets |
US6607751B1 (en) * | 1997-10-10 | 2003-08-19 | Intellipharamaceutics Corp. | Controlled release delivery device for pharmaceutical agents incorporating microbial polysaccharide gum |
EP1067910B1 (en) * | 1998-04-03 | 2004-05-26 | Egalet A/S | Controlled release composition |
US20090149479A1 (en) * | 1998-11-02 | 2009-06-11 | Elan Pharma International Limited | Dosing regimen |
DE10026698A1 (de) | 2000-05-30 | 2001-12-06 | Basf Ag | Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung |
WO2003024430A1 (en) | 2001-09-21 | 2003-03-27 | Egalet A/S | Morphine polymer release system |
EP2957281A1 (en) * | 2001-09-21 | 2015-12-23 | Egalet Ltd. | Polymer release system |
BR0206062A (pt) | 2001-09-28 | 2004-01-13 | Mcneil Ppc Inc | Formas de dosagem tendo um núcleo interno e invólucro externo |
US9358214B2 (en) | 2001-10-04 | 2016-06-07 | Adare Pharmaceuticals, Inc. | Timed, sustained release systems for propranolol |
GB0203296D0 (en) | 2002-02-12 | 2002-03-27 | Glaxo Group Ltd | Novel composition |
AU2003211146B2 (en) * | 2002-02-21 | 2007-07-19 | Valeant International (Barbados) Srl | Controlled release dosage forms |
US8323692B2 (en) | 2002-02-21 | 2012-12-04 | Valeant International Bermuda | Controlled release dosage forms |
US7169450B2 (en) | 2002-05-15 | 2007-01-30 | Mcneil-Ppc, Inc. | Enrobed core |
US20040161474A1 (en) * | 2002-05-24 | 2004-08-19 | Moerck Rudi E. | Rare earth metal compounds methods of making, and methods of using the same |
US20060083791A1 (en) * | 2002-05-24 | 2006-04-20 | Moerck Rudi E | Rare earth metal compounds methods of making, and methods of using the same |
US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
US8637512B2 (en) | 2002-07-29 | 2014-01-28 | Glaxo Group Limited | Formulations and method of treatment |
AU2003302881A1 (en) * | 2002-12-11 | 2004-06-30 | Ranbaxy Laboratories Limited | Coating composition for taste masking coating and methods for their application and use |
GB0229258D0 (en) * | 2002-12-16 | 2003-01-22 | Boots Healthcare Int Ltd | Medicinal compositions |
US8367111B2 (en) | 2002-12-31 | 2013-02-05 | Aptalis Pharmatech, Inc. | Extended release dosage forms of propranolol hydrochloride |
US20050220870A1 (en) * | 2003-02-20 | 2005-10-06 | Bonnie Hepburn | Novel formulation, omeprazole antacid complex-immediate release for rapid and sustained suppression of gastric acid |
ES2360102T3 (es) | 2003-03-26 | 2011-05-31 | Egalet A/S | Sistema para la liberación controlada de morfina. |
ATE454886T1 (de) * | 2003-03-26 | 2010-01-15 | Egalet As | Matrixzubereitungen für die kontrollierte darreichung von arzneistoffen |
JP4908200B2 (ja) * | 2003-04-24 | 2012-04-04 | ヤゴテック アーゲー | 着色されたコアを有する錠剤 |
EP1631251B1 (en) | 2003-04-24 | 2011-06-15 | Jagotec AG | Delayed release tablet with defined core geometry |
JP2007502331A (ja) * | 2003-05-29 | 2007-02-08 | グリュコン テクノロジーズ グループ エルエルシー | (−)−ヒドロキシクエン酸を安定して制御送達するための方法および組成物 |
CA2529984C (en) | 2003-06-26 | 2012-09-25 | Isa Odidi | Oral multi-functional pharmaceutical capsule preparations of proton pump inhibitors |
US8993599B2 (en) | 2003-07-18 | 2015-03-31 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
ES2654062T3 (es) | 2003-07-24 | 2018-02-12 | Glaxosmithkline Llc | Películas de disolución oral |
DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
US8075872B2 (en) | 2003-08-06 | 2011-12-13 | Gruenenthal Gmbh | Abuse-proofed dosage form |
DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
DE102004032051A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform |
DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
US8062672B2 (en) * | 2003-08-12 | 2011-11-22 | Shionogi Inc. | Antibiotic product, use and formulation thereof |
US8377952B2 (en) | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
JP2005075826A (ja) * | 2003-08-29 | 2005-03-24 | Boehringer Ingelheim Internatl Gmbh | 多孔質シリカ担体を含有する徐放性製剤 |
GB0320854D0 (en) | 2003-09-05 | 2003-10-08 | Arrow No 7 Ltd | Buccal drug delivery |
AU2004289248B2 (en) | 2003-11-07 | 2012-05-03 | U.S. Smokeless Tobacco Company Llc | Tobacco compositions |
US8627828B2 (en) | 2003-11-07 | 2014-01-14 | U.S. Smokeless Tobacco Company Llc | Tobacco compositions |
US7879354B2 (en) | 2004-01-13 | 2011-02-01 | Mcneil-Ppc, Inc. | Rapidly disintegrating gelatinous coated tablets |
US8067029B2 (en) | 2004-01-13 | 2011-11-29 | Mcneil-Ppc, Inc. | Rapidly disintegrating gelatinous coated tablets |
US20050196447A1 (en) * | 2004-03-05 | 2005-09-08 | Huang Hai Y. | Polymeric compositions and dosage forms comprising the same |
US20050196446A1 (en) * | 2004-03-05 | 2005-09-08 | Huang Hai Y. | Polymeric compositions and dosage forms comprising the same |
US20050196442A1 (en) * | 2004-03-05 | 2005-09-08 | Huang Hai Y. | Polymeric compositions and dosage forms comprising the same |
US20050196448A1 (en) * | 2004-03-05 | 2005-09-08 | Hai Yong Huang | Polymeric compositions and dosage forms comprising the same |
CN1929838B (zh) * | 2004-03-10 | 2012-05-09 | 大正制药株式会社 | 含有难溶于水的药物的固体制剂 |
US8545881B2 (en) | 2004-04-19 | 2013-10-01 | Eurand Pharmaceuticals, Ltd. | Orally disintegrating tablets and methods of manufacture |
ES2517244T3 (es) * | 2004-05-11 | 2014-11-03 | Egalet Ltd. | Forma farmacéutica hinchable que comprende goma gellan |
US7622137B2 (en) * | 2004-05-21 | 2009-11-24 | Accu-Break Technologies, Inc. | Dosage forms contained within a capsule or sachet |
US8815916B2 (en) | 2004-05-25 | 2014-08-26 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
US8906940B2 (en) | 2004-05-25 | 2014-12-09 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
US20060002986A1 (en) * | 2004-06-09 | 2006-01-05 | Smithkline Beecham Corporation | Pharmaceutical product |
TWI356036B (en) * | 2004-06-09 | 2012-01-11 | Smithkline Beecham Corp | Apparatus and method for pharmaceutical production |
US20050281876A1 (en) * | 2004-06-18 | 2005-12-22 | Shun-Por Li | Solid dosage form for acid-labile active ingredient |
US8394409B2 (en) | 2004-07-01 | 2013-03-12 | Intellipharmaceutics Corp. | Controlled extended drug release technology |
DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
US8609198B2 (en) * | 2004-07-21 | 2013-12-17 | Hewlett-Packard Development Company, L.P. | Pharmaceutical dose form with a patterned coating and method of making the same |
WO2006012634A1 (en) * | 2004-07-26 | 2006-02-02 | Teva Pharmaceutical Indudstries, Ltd. | Dosage forms with an enterically coated core tablet |
US7621734B2 (en) | 2004-07-28 | 2009-11-24 | Mars, Incorporated | Apparatus and process for preparing confectionery having an inclusion therein using forming rolls and a forming pin |
US20060024361A1 (en) * | 2004-07-28 | 2006-02-02 | Isa Odidi | Disintegrant assisted controlled release technology |
US20060024368A1 (en) * | 2004-07-30 | 2006-02-02 | Reza Fassihi | Compressed composite delivery system for release-rate modulation of bioactives |
EP1639899A1 (en) * | 2004-08-23 | 2006-03-29 | Friesland Brands B.V. | Powdered, cold-water soluble/dispersible, foamable composition |
US10624858B2 (en) * | 2004-08-23 | 2020-04-21 | Intellipharmaceutics Corp | Controlled release composition using transition coating, and method of preparing same |
AU2005286288A1 (en) * | 2004-09-24 | 2006-03-30 | Bioprogress Technology Limited | Additional improvements in powder compaction and enrobing |
EP1944008A3 (en) * | 2004-09-24 | 2008-07-23 | BioProgress Technology Limited | Additional improvements in powder compaction and enrobing |
EP1799453B1 (en) * | 2004-09-30 | 2012-09-05 | MonoSolRX, LLC | Multi-layer films having uniform content |
US9884014B2 (en) | 2004-10-12 | 2018-02-06 | Adare Pharmaceuticals, Inc. | Taste-masked pharmaceutical compositions |
WO2006044657A2 (en) * | 2004-10-15 | 2006-04-27 | Altairnano, Inc. | Phosphate binder with reduced pill burden |
EP1802285B1 (en) | 2004-10-21 | 2013-02-27 | Aptalis Pharmatech, Inc. | Taste-masked pharmaceutical compositions with gastrosoluble pore-formers |
US8383159B2 (en) | 2004-10-27 | 2013-02-26 | Mcneil-Ppc, Inc. | Dosage forms having a microreliefed surface and methods and apparatus for their production |
US20060087051A1 (en) * | 2004-10-27 | 2006-04-27 | Bunick Frank J | Dosage forms having a microreliefed surface and methods and apparatus for their production |
US20060088587A1 (en) * | 2004-10-27 | 2006-04-27 | Bunick Frank J | Dosage forms having a microreliefed surface and methods and apparatus for their production |
US20070281022A1 (en) * | 2004-10-27 | 2007-12-06 | Bunick Frank J | Dosage forms having a microreliefed surface and methods and apparatus for their production |
US20060088593A1 (en) * | 2004-10-27 | 2006-04-27 | Bunick Frank J | Dosage forms having a microreliefed surface and methods and apparatus for their production |
US20070190133A1 (en) * | 2004-10-27 | 2007-08-16 | Bunick Frank J | Dosage forms having a microreliefed surface and methods and apparatus for their production |
US20060088586A1 (en) * | 2004-10-27 | 2006-04-27 | Bunick Frank J | Dosage forms having a microreliefed surface and methods and apparatus for their production |
GB0423964D0 (en) * | 2004-10-28 | 2004-12-01 | Jagotec Ag | Dosage form |
US20060093560A1 (en) * | 2004-10-29 | 2006-05-04 | Jen-Chi Chen | Immediate release film coating |
AR051654A1 (es) * | 2004-11-04 | 2007-01-31 | Astrazeneca Ab | Nuevas formulaciones de pellets de liberacion modificada para inhibidores de la bomba de protones |
AR052225A1 (es) * | 2004-11-04 | 2007-03-07 | Astrazeneca Ab | Formulaciones de tabletas de liberacion modificada par inhibidores de la bomba de protones |
EP1836665B1 (en) | 2004-11-19 | 2013-01-16 | GlaxoSmithKline LLC | Method for customized dispensing of variable dose drug combination products for individualizing of therapies |
US7404708B2 (en) * | 2004-12-07 | 2008-07-29 | Mcneil-Ppc, Inc. | System and process for providing at least one opening in dosage forms |
US7530804B2 (en) * | 2004-12-07 | 2009-05-12 | Mcneil-Ppc, Inc. | System and process for providing at least one opening in dosage forms |
US20070129402A1 (en) * | 2004-12-27 | 2007-06-07 | Eisai Research Institute | Sustained release formulations |
WO2006070930A1 (en) | 2004-12-27 | 2006-07-06 | Eisai R & D Management Co., Ltd. | Method for stabilizing anti-dementia drug |
WO2006072577A1 (en) * | 2005-01-07 | 2006-07-13 | Sandoz Ag | Process for preparing granulates comprising amoxicillin |
DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
WO2006099618A1 (en) * | 2005-03-16 | 2006-09-21 | Dr. Reddy's Laboratories Ltd. | Delivery system for multiple drugs |
JP2008535837A (ja) * | 2005-04-06 | 2008-09-04 | マリンクロッド・インコーポレイテッド | マトリックスをベースとするパルス放出製剤 |
EA200702221A1 (ru) * | 2005-04-12 | 2008-04-28 | Элан Фарма Интернэшнл Лимитед | Композиции с контролируемым высвобождением для лечения бактериальной инфекции, содержащие цефалоспорин |
US20060233882A1 (en) * | 2005-04-15 | 2006-10-19 | Sowden Harry S | Osmotic dosage form |
US8673352B2 (en) * | 2005-04-15 | 2014-03-18 | Mcneil-Ppc, Inc. | Modified release dosage form |
CN101287411B (zh) | 2005-04-28 | 2013-03-06 | 普罗秋斯生物医学公司 | 药物信息系统及其用途 |
CA2604617C (en) * | 2005-04-28 | 2014-06-17 | Eisai R&D Management Co., Ltd. | Composition containing anti-dementia drug |
US8802183B2 (en) | 2005-04-28 | 2014-08-12 | Proteus Digital Health, Inc. | Communication system with enhanced partial power source and method of manufacturing same |
US9161918B2 (en) | 2005-05-02 | 2015-10-20 | Adare Pharmaceuticals, Inc. | Timed, pulsatile release systems |
DE602006020133D1 (de) * | 2005-05-18 | 2011-03-31 | Goemar Lab Sa | Laminarin-enthaltende lebensmittel |
AU2006254554B2 (en) * | 2005-06-03 | 2011-11-24 | Egalet Ltd | A solid pharmaceutical composition with a first fraction of a dispersion medium and a second fraction of a matrix, the latter being at least partially first exposed to gastrointestinal fluids |
ZA200711123B (en) | 2005-06-27 | 2009-08-26 | Biovail Lab Int Srl | Modified-release formulations of a bupropion salt |
US20070009573A1 (en) * | 2005-07-07 | 2007-01-11 | L N K International | Method of forming immediate release dosage form |
DE102005034043B4 (de) * | 2005-07-18 | 2019-12-12 | Südzucker Aktiengesellschaft Mannheim/Ochsenfurt | Gemisch, enthaltend L-Carnitin und Trehalulose, sowie Produkt enthaltend das Gemisch |
US20070015834A1 (en) * | 2005-07-18 | 2007-01-18 | Moshe Flashner-Barak | Formulations of fenofibrate containing PEG/Poloxamer |
WO2007022445A2 (en) * | 2005-08-17 | 2007-02-22 | Altairnano, Inc. | Treatment of chronic renal failure and other conditions in domestic animals: compositions and methods |
TWI274889B (en) * | 2005-10-06 | 2007-03-01 | Elan Microelectronics Corp | Resistive touch screen measurement system |
US20070112075A1 (en) * | 2005-10-14 | 2007-05-17 | Forest Laboratories, Inc. | Stable pharmaceutical formulations containing escitalopram and bupropion |
US8357394B2 (en) | 2005-12-08 | 2013-01-22 | Shionogi Inc. | Compositions and methods for improved efficacy of penicillin-type antibiotics |
US8778924B2 (en) | 2006-12-04 | 2014-07-15 | Shionogi Inc. | Modified release amoxicillin products |
US10064828B1 (en) | 2005-12-23 | 2018-09-04 | Intellipharmaceutics Corp. | Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems |
WO2007086846A1 (en) * | 2006-01-24 | 2007-08-02 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
JP2007224012A (ja) * | 2006-01-30 | 2007-09-06 | Fujifilm Corp | 酵素架橋したタンパク質ナノ粒子 |
US20070184111A1 (en) * | 2006-02-03 | 2007-08-09 | Pharmavite Llc | Hybrid tablet |
US20070190131A1 (en) * | 2006-02-10 | 2007-08-16 | Perry Ronald L | Press-fit rapid release medicament and method and apparatus of manufacturing |
US20070224258A1 (en) * | 2006-03-22 | 2007-09-27 | Bunick Frank J | Dosage forms having a randomized coating |
CN101460153B (zh) * | 2006-03-28 | 2012-06-13 | 麦克内尔-Ppc股份有限公司 | 非均质剂型包衣 |
CN101453996B (zh) * | 2006-04-03 | 2016-05-11 | 伊萨·奥迪迪 | 药物递送组合物 |
EP2007360B1 (en) | 2006-04-03 | 2014-11-26 | Isa Odidi | Controlled release delivery device comprising an organosol coat |
US10960077B2 (en) | 2006-05-12 | 2021-03-30 | Intellipharmaceutics Corp. | Abuse and alcohol resistant drug composition |
US20070293587A1 (en) * | 2006-05-23 | 2007-12-20 | Haley Jeffrey T | Combating sinus, throat, and blood infections with xylitol delivered in the mouth |
JP5410964B2 (ja) * | 2006-05-23 | 2014-02-05 | オラヘルス コーポレーション | 付着性アカシアゴムを含む二層構造の口腔内付着錠 |
WO2007149860A1 (en) * | 2006-06-19 | 2007-12-27 | Accu-Break Technologies, Inc. | Segmented pharmaceutical dosage forms |
SG174026A1 (en) | 2006-08-03 | 2011-09-29 | Nitec Pharma Ag | Delayed-release glucocorticoid treatment of rheumatoid disease |
SA07280459B1 (ar) | 2006-08-25 | 2011-07-20 | بيورديو فارما إل. بي. | أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني |
US8399230B2 (en) * | 2006-10-12 | 2013-03-19 | Kemin Industries, Inc. | Heat-stable enzyme compositions |
EP1916006A1 (en) * | 2006-10-19 | 2008-04-30 | Albert Schömig | Implant coated with a wax or a resin |
JP5389656B2 (ja) | 2006-10-20 | 2014-01-15 | マクニール−ピーピーシー・インコーポレーテツド | アセトアミノフェン/イブプロフェンの組み合わせおよびこれらの使用方法 |
CN101528205A (zh) * | 2006-10-25 | 2009-09-09 | 麦克内尔-Ppc股份有限公司 | 布洛芬组合物 |
EP2104493A2 (en) * | 2007-01-16 | 2009-09-30 | Egalet A/S | Use of i) a polyglycol and n) an active drug substance for the preparation of a pharmaceutical composition for i) mitigating the risk of alcohol induced dose dumping and/or ii) reducing the risk of drug abuse |
US7767248B2 (en) | 2007-02-02 | 2010-08-03 | Overly Iii Harry J | Soft chew confectionary with high fiber and sugar content and method for making same |
GB0702974D0 (en) * | 2007-02-15 | 2007-03-28 | Jagotec Ag | Method and apparatus for producing a tablet |
JP5224790B2 (ja) * | 2007-03-02 | 2013-07-03 | 株式会社明治 | 固形食品およびその製造方法 |
WO2008109018A1 (en) * | 2007-03-02 | 2008-09-12 | Meda Pharmaceuticals Inc. | Compositions comprising carisoprodol and methods of use thereof |
DE102007011485A1 (de) | 2007-03-07 | 2008-09-11 | Grünenthal GmbH | Darreichungsform mit erschwertem Missbrauch |
US20080292692A1 (en) * | 2007-05-21 | 2008-11-27 | Shira Pilch | Impermeable Capsules |
US20080300322A1 (en) * | 2007-06-01 | 2008-12-04 | Atlantic Pharmaceuticals, Inc. | Delivery vehicles containing rosin resins |
EP2155167A2 (en) | 2007-06-04 | 2010-02-24 | Egalet A/S | Controlled release pharmaceutical compositions for prolonged effect |
MX2009012974A (es) * | 2007-06-11 | 2010-01-18 | Appleton Paper Inc | Agente benefico que contiene una particula de suministro. |
US20080317677A1 (en) * | 2007-06-22 | 2008-12-25 | Szymczak Christopher E | Laser Marked Dosage Forms |
US20080317678A1 (en) * | 2007-06-22 | 2008-12-25 | Szymczak Christopher E | Laser Marked Dosage Forms |
US20090004248A1 (en) * | 2007-06-29 | 2009-01-01 | Frank Bunick | Dual portion dosage lozenge form |
CA2923102C (en) | 2007-08-13 | 2019-10-15 | Abuse Deterrent Pharmaceutical Llc | Abuse resistant drugs, method of use and method of making |
US20090060983A1 (en) * | 2007-08-30 | 2009-03-05 | Bunick Frank J | Method And Composition For Making An Orally Disintegrating Dosage Form |
WO2009036287A1 (en) * | 2007-09-12 | 2009-03-19 | Elan Pharma International Limited | Dosing regimen |
TW200930343A (en) * | 2007-09-21 | 2009-07-16 | Organon Nv | Drug delivery system |
FR2921835B1 (fr) * | 2007-10-05 | 2012-05-04 | Soc Dexploitation De Produits Pour Les Industries Chimiques Seppic | Composition d'enrobage comprenant du polydextrose, procede pour sa preparation et utilisation pour enrober les formes solides ingerables |
US8789536B2 (en) | 2007-10-17 | 2014-07-29 | The Invention Science Fund I, Llc | Medical or veterinary digestive tract utilization systems and methods |
US8303573B2 (en) | 2007-10-17 | 2012-11-06 | The Invention Science Fund I, Llc | Medical or veterinary digestive tract utilization systems and methods |
US20090105561A1 (en) * | 2007-10-17 | 2009-04-23 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Medical or veterinary digestive tract utilization systems and methods |
US8707964B2 (en) * | 2007-10-31 | 2014-04-29 | The Invention Science Fund I, Llc | Medical or veterinary digestive tract utilization systems and methods |
SI2180882T1 (sl) † | 2007-10-19 | 2013-05-31 | Otsuka Pharmaceutical Co., Ltd. | Trdni matriksni farmacevtski pripravek |
US8808276B2 (en) * | 2007-10-23 | 2014-08-19 | The Invention Science Fund I, Llc | Adaptive dispensation in a digestive tract |
RU2482839C2 (ru) * | 2007-10-31 | 2013-05-27 | МакНЕЙЛС-ППС, ИНК. | Распадающаяся в полости рта лекарственная форма |
US8109920B2 (en) * | 2007-10-31 | 2012-02-07 | The Invention Science Fund I, Llc | Medical or veterinary digestive tract utilization systems and methods |
US20090163894A1 (en) * | 2007-10-31 | 2009-06-25 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Medical or veterinary digestive tract utilization systems and methods |
US8333754B2 (en) * | 2007-10-31 | 2012-12-18 | The Invention Science Fund I, Llc | Medical or veterinary digestive tract utilization systems and methods |
US8808271B2 (en) * | 2007-10-31 | 2014-08-19 | The Invention Science Fund I, Llc | Medical or veterinary digestive tract utilization systems and methods |
US20090137866A1 (en) * | 2007-11-28 | 2009-05-28 | Searete Llc, A Limited Liability Corporation Of The State Delaware | Medical or veterinary digestive tract utilization systems and methods |
CA2930063C (en) | 2008-01-04 | 2017-01-31 | Schabar Research Associates Llc | Unit oral solid dose compositions composed of naproxen sodium and nizatidine |
MX2010008138A (es) | 2008-01-25 | 2010-08-10 | Gruenenthal Gmbh | Forma de dosis farmaceutica. |
WO2009154810A2 (en) * | 2008-02-25 | 2009-12-23 | Dr. Reddy's Laboratories Ltd. | Delivery systems for multiple active agents |
US8372432B2 (en) | 2008-03-11 | 2013-02-12 | Depomed, Inc. | Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic |
AU2009223061B2 (en) | 2008-03-11 | 2014-10-09 | Depomed Inc. | Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic |
US20090280175A1 (en) * | 2008-05-09 | 2009-11-12 | Ishwar Chauhan | Multilayer Proton Pump Inhibitor Tablets |
RU2508092C2 (ru) | 2008-05-09 | 2014-02-27 | Грюненталь Гмбх | Способ получения твердой лекарственной формы, в частности таблетки для фармацевтического применения, и способ получения прекурсора твердой лекарственной формы, в частности таблетки |
EP2297793A4 (en) * | 2008-05-14 | 2014-08-06 | Intercontinental Great Brands Llc | CONFECTIONERY WITH ENZYMATICALLY MODIFIED TEXTURE |
WO2009146537A1 (en) * | 2008-06-02 | 2009-12-10 | Pharmascience Inc. | Multilayer control-release drug delivery system |
KR200452140Y1 (ko) * | 2008-06-20 | 2011-02-08 | 주식회사 부성시스템 | 비닐하우스의 부직포개폐기용 제어장치 |
DK2299953T3 (en) * | 2008-07-14 | 2017-06-19 | Polypid Ltd | CARBON COMPOSITION FOR MEDICINAL PRODUCTS WITH CONTINUOUS EXPOSURE |
KR200450450Y1 (ko) * | 2008-07-16 | 2010-10-04 | 이봉석 | 포지션 리미트 스위치 케이스 |
AU2009279619A1 (en) * | 2008-08-07 | 2010-02-11 | Avantor Performance Materials, Inc. | Sustained release compositions comprising gums and sugar alcohols |
US8038424B2 (en) | 2008-09-22 | 2011-10-18 | Xerox Corporation | System and method for manufacturing sold ink sticks with an injection molding process |
FR2936952A1 (fr) * | 2008-10-09 | 2010-04-16 | Monique Bellec | Administration par voie orale de medicaments et complements nutritionnels |
IT1394597B1 (it) * | 2008-11-05 | 2012-07-05 | Politi | Granulazione a secco in flusso di gas. |
WO2010067478A1 (ja) * | 2008-12-12 | 2010-06-17 | 株式会社ミツヤコーポレーション | 食品およびその加工方法 |
TWI494108B (zh) * | 2009-01-26 | 2015-08-01 | Nitec Pharma Ag | 糖皮質激素用以製備嚴重夜間氣喘用之於延遲釋放型的藥物之用途 |
ES2607209T3 (es) | 2009-02-06 | 2017-03-29 | Egalet Ltd. | Composiciones farmacéuticas resistentes al abuso |
EP2393484A1 (en) | 2009-02-06 | 2011-12-14 | Egalet Ltd. | Immediate release composition resistant to abuse by intake of alcohol |
BRPI1007945C8 (pt) * | 2009-02-13 | 2021-05-25 | Romark Laboratories Lc | formulação farmacêutica de liberação controlada de nitazoxanida, tizoxanida ou uma combinação dos mesmos, e, comprimido de bicamada para administração oral |
SG10201810784SA (en) | 2009-04-28 | 2018-12-28 | Proteus Digital Health Inc | Highly Reliable Ingestible Event Markers And Methods For Using The Same |
US8388983B2 (en) * | 2009-05-12 | 2013-03-05 | Bpsi Holdings, Llc | Film coatings containing fine particle size detackifiers and substrates coated therewith |
WO2010133961A1 (en) | 2009-05-22 | 2010-11-25 | Inventia Healthcare Private Limited | Extended release compositions of cyclobenzaprine |
AU2010265213B2 (en) | 2009-06-24 | 2012-08-23 | Egalet Ltd. | Controlled release formulations |
CN105126179B (zh) | 2009-07-14 | 2018-09-25 | 波利皮得有限公司 | 持续释放药物载体组合物 |
WO2011009604A1 (en) | 2009-07-22 | 2011-01-27 | Grünenthal GmbH | Oxidation-stabilized tamper-resistant dosage form |
AR077493A1 (es) | 2009-07-22 | 2011-08-31 | Gruenenthal Gmbh | Composicion farmaceutica extruida en caliente con liberacion controlada. procedimiento de preparacion |
WO2011010723A1 (ja) * | 2009-07-24 | 2011-01-27 | キャドバリー・ジャパン株式会社 | 複数領域菓子及びその製造方法 |
JP2013501068A (ja) | 2009-08-05 | 2013-01-10 | アイディニックス ファーマシューティカルズ インコーポレイテッド | 大環状セリンプロテアーゼ阻害剤 |
WO2011025673A1 (en) * | 2009-08-26 | 2011-03-03 | Aptapharma, Inc. | Multilayer minitablets |
CN102596252A (zh) * | 2009-08-31 | 2012-07-18 | 蒂宝制药公司 | 用于对乙酰氨基酚的立即和延长释放的胃滞留药物组合物 |
MX2012002004A (es) * | 2009-09-01 | 2012-02-29 | Rhodia Operations | Composiciones de polimero. |
US8313768B2 (en) * | 2009-09-24 | 2012-11-20 | Mcneil-Ppc, Inc. | Manufacture of tablet having immediate release region and sustained release region |
US8858210B2 (en) | 2009-09-24 | 2014-10-14 | Mcneil-Ppc, Inc. | Manufacture of variable density dosage forms utilizing radiofrequency energy |
US20110070286A1 (en) * | 2009-09-24 | 2011-03-24 | Andreas Hugerth | Process for the manufacture of nicotine-comprising chewing gum and nicotine-comprising chewing gum manufactured according to said process |
US9610224B2 (en) * | 2009-09-24 | 2017-04-04 | Johnson & Johnson Consumer Inc. | Manufacture of tablet in a die utilizing powder blend containing water-containing material |
EP2316432A1 (de) * | 2009-10-30 | 2011-05-04 | ratiopharm GmbH | Zusammensetzung enthaltend Fesoterodin und Ballaststoffe |
WO2011056764A1 (en) | 2009-11-05 | 2011-05-12 | Ambit Biosciences Corp. | Isotopically enriched or fluorinated imidazo[2,1-b][1,3]benzothiazoles |
AU2010325746B2 (en) | 2009-12-02 | 2016-02-25 | Adare Pharmaceuticals S.R.L. | Fexofenadine microcapsules and compositions containing them |
UA109424C2 (uk) * | 2009-12-02 | 2015-08-25 | Фармацевтичний продукт, фармацевтична таблетка з електронним маркером і спосіб виготовлення фармацевтичної таблетки | |
CN102639122A (zh) * | 2009-12-07 | 2012-08-15 | 麦克内尔-Ppc股份有限公司 | 调释剂型的部分浸渍包衣 |
JP2013514982A (ja) | 2009-12-18 | 2013-05-02 | イデニク プハルマセウティカルス,インコーポレイテッド | 5,5−縮合アリーレン又はヘテロアリーレンc型肝炎ウイルス阻害剤 |
US10485770B2 (en) | 2009-12-21 | 2019-11-26 | Aptapharma, Inc. | Functionally-coated multilayer tablets |
AU2011208374B2 (en) | 2010-01-19 | 2016-09-08 | Polypid Ltd. | Sustained-release nucleic acid matrix compositions |
WO2011094890A1 (en) | 2010-02-02 | 2011-08-11 | Argusina Inc. | Phenylalanine derivatives and their use as non-peptide glp-1 receptor modulators |
CN102821757B (zh) | 2010-02-03 | 2016-01-20 | 格吕伦塔尔有限公司 | 通过挤出机制备粉末状药物组合物 |
US9138309B2 (en) | 2010-02-05 | 2015-09-22 | Allergan, Inc. | Porous materials, methods of making and uses |
US9205577B2 (en) * | 2010-02-05 | 2015-12-08 | Allergan, Inc. | Porogen compositions, methods of making and uses |
GB201003766D0 (en) | 2010-03-05 | 2010-04-21 | Univ Strathclyde | Pulsatile drug release |
GB201003734D0 (en) * | 2010-03-05 | 2010-04-21 | Univ Strathclyde | Delayed prolonged drug delivery |
GB201003731D0 (en) | 2010-03-05 | 2010-04-21 | Univ Strathclyde | Immediate/delayed drug delivery |
WO2011112689A2 (en) | 2010-03-11 | 2011-09-15 | Ambit Biosciences Corp. | Saltz of an indazolylpyrrolotriazine |
EP2544887A1 (en) * | 2010-03-11 | 2013-01-16 | Wockhardt Limited | A device for the manufacture of a dosage form with a hole and method of manufacture |
US8486013B2 (en) * | 2010-03-18 | 2013-07-16 | Biotronik Ag | Balloon catheter having coating |
US9743688B2 (en) * | 2010-03-26 | 2017-08-29 | Philip Morris Usa Inc. | Emulsion/colloid mediated flavor encapsulation and delivery with tobacco-derived lipids |
TWI638652B (zh) | 2010-04-07 | 2018-10-21 | 波提亞斯數位康健公司 | 微型可攝取裝置 |
US11202853B2 (en) * | 2010-05-11 | 2021-12-21 | Allergan, Inc. | Porogen compositions, methods of making and uses |
TWI446916B (zh) | 2010-05-12 | 2014-08-01 | Spectrum Pharmaceuticals Inc | 鹼式碳酸鑭、碳酸氧鑭及其製備方法及用途 |
US20110280936A1 (en) * | 2010-05-17 | 2011-11-17 | Aptapharma, Inc. | Self Breaking Tablets |
WO2011161666A2 (en) * | 2010-06-21 | 2011-12-29 | White Innovation Ltd. | Enclosed liquid capsules |
ES2619850T3 (es) | 2010-09-01 | 2017-06-27 | Ambit Biosciences Corporation | Sales de hidrobromuro de una pirazolilaminoquinazolina |
WO2012030917A1 (en) | 2010-09-01 | 2012-03-08 | Ambit Biosciences Corporation | An optically active pyrazolylaminoquinazoline, and pharmaceutical compositions and methods of use thereof |
WO2012028319A1 (en) | 2010-09-02 | 2012-03-08 | Grünenthal GmbH | Tamper resistant dosage form comprising inorganic salt |
AR082862A1 (es) | 2010-09-02 | 2013-01-16 | Gruenenthal Gmbh | Forma de dosificacion resistente a alteracion que comprende un polimero anionico |
WO2012071280A2 (en) | 2010-11-22 | 2012-05-31 | Proteus Biomedical, Inc. | Ingestible device with pharmaceutical product |
US20140079686A1 (en) | 2010-12-06 | 2014-03-20 | Shikha P. Barman | Methods For Treating Baldness And Promoting Hair Growth |
US10821085B2 (en) * | 2010-12-07 | 2020-11-03 | Kimberly-Clark Worldwide, Inc. | Wipe coated with a botanical composition having antimicrobial properties |
AU2011342893A1 (en) | 2010-12-13 | 2013-05-02 | Purdue Pharma L.P. | Controlled release dosage forms |
WO2012080050A1 (en) | 2010-12-14 | 2012-06-21 | F. Hoffmann-La Roche Ag | Solid forms of a phenoxybenzenesulfonyl compound |
CN103338753A (zh) | 2011-01-31 | 2013-10-02 | 细胞基因公司 | 胞苷类似物的药物组合物及其使用方法 |
US9353100B2 (en) | 2011-02-10 | 2016-05-31 | Idenix Pharmaceuticals Llc | Macrocyclic serine protease inhibitors, pharmaceutical compositions thereof, and their use for treating HCV infections |
US20120252721A1 (en) | 2011-03-31 | 2012-10-04 | Idenix Pharmaceuticals, Inc. | Methods for treating drug-resistant hepatitis c virus infection with a 5,5-fused arylene or heteroarylene hepatitis c virus inhibitor |
KR102059698B1 (ko) | 2011-06-06 | 2019-12-26 | 오크 크레스트 인스티튜트 오브 사이언스 | 심지 방출창을 도입한 약물 전달 장치 |
USD723766S1 (en) | 2011-06-30 | 2015-03-10 | Intercontinental Great Brands Llc | Confectionary article |
US9756874B2 (en) | 2011-07-11 | 2017-09-12 | Proteus Digital Health, Inc. | Masticable ingestible product and communication system therefor |
WO2015112603A1 (en) | 2014-01-21 | 2015-07-30 | Proteus Digital Health, Inc. | Masticable ingestible product and communication system therefor |
NO2736497T3 (zh) | 2011-07-29 | 2018-01-20 | ||
KR20140053159A (ko) | 2011-07-29 | 2014-05-07 | 그뤼넨탈 게엠베하 | 즉시 약물 방출을 제공하는 탬퍼-저항성 정제 |
US9629392B2 (en) | 2011-09-22 | 2017-04-25 | R.J. Reynolds Tobacco Company | Translucent smokeless tobacco product |
US9084439B2 (en) * | 2011-09-22 | 2015-07-21 | R.J. Reynolds Tobacco Company | Translucent smokeless tobacco product |
US9474303B2 (en) | 2011-09-22 | 2016-10-25 | R.J. Reynolds Tobacco Company | Translucent smokeless tobacco product |
US20130078307A1 (en) | 2011-09-22 | 2013-03-28 | Niconovum Usa, Inc. | Nicotine-containing pharmaceutical composition |
RU2570315C1 (ru) | 2011-10-14 | 2015-12-10 | Хилл'С Пет Ньютришн, Инк. | Способ приготовления кормовой композиции для домашних животных |
KR101384055B1 (ko) * | 2012-02-02 | 2014-04-14 | 한국원자력연구원 | 버스트형 지연 방출 제어 조성물 및 이의 제조방법 |
WO2013127831A1 (en) | 2012-02-28 | 2013-09-06 | Grünenthal GmbH | Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer |
US8916555B2 (en) | 2012-03-16 | 2014-12-23 | Axikin Pharmaceuticals, Inc. | 3,5-diaminopyrazole kinase inhibitors |
US20130261372A1 (en) * | 2012-03-30 | 2013-10-03 | Elwha LLC, a limited liability company of the State of Delaware | Device, System, and Method for Delivery of Sugar Glass Stabilized Compositions |
PT2838512T (pt) | 2012-04-18 | 2018-11-09 | Gruenenthal Gmbh | Forma farmacêutica resistente à adulteração e resistente à libertação inesperada de alta quantidade (dose-dumping) |
WO2013165961A1 (en) * | 2012-04-30 | 2013-11-07 | Bettinger, Christopher J. | A water-activated, ingestible battery |
US9445971B2 (en) * | 2012-05-01 | 2016-09-20 | Johnson & Johnson Consumer Inc. | Method of manufacturing solid dosage form |
US9233491B2 (en) | 2012-05-01 | 2016-01-12 | Johnson & Johnson Consumer Inc. | Machine for production of solid dosage forms |
US9511028B2 (en) | 2012-05-01 | 2016-12-06 | Johnson & Johnson Consumer Inc. | Orally disintegrating tablet |
US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
TW201400146A (zh) * | 2012-06-05 | 2014-01-01 | Takeda Pharmaceutical | 有核錠 |
US9549899B2 (en) | 2012-07-06 | 2017-01-24 | Egalet Ltd. | Abuse deterrent pharmaceutical compositions for controlled release |
CN102824640A (zh) * | 2012-08-06 | 2012-12-19 | 济南圣泉唐和唐生物科技有限公司 | 一种胶囊壳及其制备方法 |
US20140193543A1 (en) * | 2013-01-09 | 2014-07-10 | Alexander Vigneri | Decorative hollow chocolate confection with improved writability |
TWI659994B (zh) | 2013-01-29 | 2019-05-21 | 美商普羅托斯數位健康公司 | 高度可膨脹之聚合型薄膜及包含彼之組成物 |
DE102013004263A1 (de) | 2013-03-13 | 2014-09-18 | Martin Lipsdorf | Schnell lösliche orale Darreichungsform und Methode zur Herstellung derselben |
US10175376B2 (en) | 2013-03-15 | 2019-01-08 | Proteus Digital Health, Inc. | Metal detector apparatus, system, and method |
WO2014146093A2 (en) | 2013-03-15 | 2014-09-18 | Inspirion Delivery Technologies, Llc | Abuse deterrent compositions and methods of use |
US10130760B2 (en) * | 2013-03-15 | 2018-11-20 | Incube Labs, Llc | Multi-stage biodegradable drug delivery platform |
US9470489B2 (en) * | 2013-05-14 | 2016-10-18 | Kerry Thaddeus Bowden | Airsoft marking round |
BR112015026549A2 (pt) | 2013-05-29 | 2017-07-25 | Gruenenthal Gmbh | forma de dosagem à prova de violação contendo uma ou mais partículas |
AR096439A1 (es) | 2013-05-29 | 2015-12-30 | Gruenenthal Gmbh | Forma de dosificación resistente al uso indebido que contiene una o más partículas |
KR20160031526A (ko) | 2013-07-12 | 2016-03-22 | 그뤼넨탈 게엠베하 | 에틸렌-비닐 아세테이트 중합체를 함유하는 템퍼 내성 투여형 |
US9796576B2 (en) | 2013-08-30 | 2017-10-24 | Proteus Digital Health, Inc. | Container with electronically controlled interlock |
NZ631142A (en) | 2013-09-18 | 2016-03-31 | Axikin Pharmaceuticals Inc | Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors |
US20160229866A1 (en) | 2013-09-20 | 2016-08-11 | Idenix Pharmaceuticals Inc. | Hepatitis c virus inhibitors |
US10084880B2 (en) | 2013-11-04 | 2018-09-25 | Proteus Digital Health, Inc. | Social media networking based on physiologic information |
CN105934241B (zh) | 2013-11-26 | 2020-06-05 | 格吕伦塔尔有限公司 | 通过低温研磨制备粉末状药物组合物 |
WO2015086489A1 (en) | 2013-12-11 | 2015-06-18 | Merck Sharp & Dohme B.V. | Drug delivery system for delivery of anti-virals |
US10413504B2 (en) | 2013-12-11 | 2019-09-17 | Merck Sharp & Dohme Corp. | Intravaginal ring drug delivery system |
JP2017507165A (ja) * | 2013-12-16 | 2017-03-16 | マサチューセッツ インスティテュート オブ テクノロジー | マイクロモールド成形された、または3次元印刷されたパルス放出ワクチン製剤 |
ES2712129T3 (es) * | 2013-12-23 | 2019-05-09 | Xiaoguang Wen | Comprimido de doble capa y método de preparación del mismo |
KR20160107254A (ko) | 2014-01-10 | 2016-09-13 | 존슨 앤드 존슨 컨수머 인코포레이티드 | 고주파 및 손실 코팅된 입자를 사용하여 정제를 제조하는 방법 |
US9375033B2 (en) | 2014-02-14 | 2016-06-28 | R.J. Reynolds Tobacco Company | Tobacco-containing gel composition |
US20170066779A1 (en) | 2014-03-05 | 2017-03-09 | Idenix Pharmaceuticals Llc | Solid forms of a flaviviridae virus inhibitor compound and salts thereof |
CA2943220C (en) | 2014-03-20 | 2024-01-16 | Capella Therapeutics, Inc. | Benzimidazole derivatives as erbb tyrosine kinase inhibitors for the treatment of cancer |
CN106661027B (zh) | 2014-03-20 | 2019-12-24 | 卡佩拉医疗公司 | 苯并咪唑衍生物作为erbb酪氨酸激酶抑制剂用于治疗癌症 |
EP3142646A1 (en) | 2014-05-12 | 2017-03-22 | Grünenthal GmbH | Tamper resistant immediate release capsule formulation comprising tapentadol |
EA201692388A1 (ru) | 2014-05-26 | 2017-05-31 | Грюненталь Гмбх | Лекарственная форма в виде множества частиц, защищенная от вызываемого этанолом сброса дозы |
US10729685B2 (en) | 2014-09-15 | 2020-08-04 | Ohemo Life Sciences Inc. | Orally administrable compositions and methods of deterring abuse by intranasal administration |
EA032473B1 (ru) | 2014-12-23 | 2019-05-31 | Аксикин Фармасьютикалз, Инк. | 3,5-диаминопиразоловые ингибиторы киназы |
DE202016008309U1 (de) * | 2015-01-22 | 2017-07-14 | Pfeifer & Langen GmbH & Co. KG | Cellobiosehaltige Zuckermasse |
US10174275B2 (en) * | 2015-01-30 | 2019-01-08 | Follmann Gmbh & Co. Kg | Thermally opening stable core/shell microcapsules |
USD765828S1 (en) | 2015-02-19 | 2016-09-06 | Crossford International, Llc | Chemical tablet |
US9839212B2 (en) | 2015-04-16 | 2017-12-12 | Bio-Lab, Inc. | Multicomponent and multilayer compacted tablets |
EP3285745A1 (en) | 2015-04-24 | 2018-02-28 | Grünenthal GmbH | Tamper-resistant dosage form with immediate release and resistance against solvent extraction |
US11051543B2 (en) | 2015-07-21 | 2021-07-06 | Otsuka Pharmaceutical Co. Ltd. | Alginate on adhesive bilayer laminate film |
AU2016319203A1 (en) | 2015-09-10 | 2018-02-22 | Grünenthal GmbH | Protecting oral overdose with abuse deterrent immediate release formulations |
WO2017106812A1 (en) | 2015-12-19 | 2017-06-22 | First Time Us Generics Llc | Soft-chew tablet pharmaceutical formulations |
US20190022013A1 (en) | 2015-12-19 | 2019-01-24 | First Time Us Generics Llc | Soft-chew tablet pharmaceutical formulations |
JP2017158534A (ja) * | 2016-03-07 | 2017-09-14 | 焼津水産化学工業株式会社 | チップ状食品の製造方法及びチップ状食品 |
EP3431079B1 (en) * | 2016-03-15 | 2023-06-07 | Astellas Pharma Inc. | Tablet |
KR102051875B1 (ko) | 2016-07-22 | 2019-12-04 | 프로테우스 디지털 헬스, 인코포레이티드 | 섭취 가능한 이벤트 마커의 전자기 감지 및 검출 |
CN109661305B (zh) * | 2016-09-09 | 2022-10-28 | 默克专利股份有限公司 | 用于制备固体药物给药形式的工艺 |
AU2017331369B2 (en) | 2016-09-26 | 2019-11-21 | The Procter & Gamble Company | Extended relief dosage form |
AU2017348094B2 (en) | 2016-10-26 | 2022-10-13 | Otsuka Pharmaceutical Co., Ltd. | Methods for manufacturing capsules with ingestible event markers |
CN106945323B (zh) * | 2017-03-14 | 2018-11-02 | 常熟市双月机械有限公司 | 一种高效率的金属粉末液压机 |
US10493026B2 (en) | 2017-03-20 | 2019-12-03 | Johnson & Johnson Consumer Inc. | Process for making tablet using radiofrequency and lossy coated particles |
CN110352131A (zh) * | 2017-04-07 | 2019-10-18 | 宝洁公司 | 水溶性膜 |
DE102017107845A1 (de) * | 2017-04-11 | 2018-10-11 | Gelita Ag | Gelatineprodukt mit einer Kernkomponente und Verfahren zu dessen Herstellung |
US10450119B2 (en) | 2017-06-22 | 2019-10-22 | The Procter & Gamble Company | Films including a water-soluble layer and a vapor-deposited inorganic coating |
WO2018237212A1 (en) | 2017-06-22 | 2018-12-27 | The Procter & Gamble Company | FILMS COMPRISING A WATER-SOLUBLE LAYER AND AN ORGANIC COATING DEPOSITED IN STEAM PHASE |
US10537585B2 (en) | 2017-12-18 | 2020-01-21 | Dexcel Pharma Technologies Ltd. | Compositions comprising dexamethasone |
US11000471B2 (en) * | 2018-03-05 | 2021-05-11 | Kashiv Specialty Pharmaceuticals, Llc | Programmable pharmaceutical compositions for chrono drug release |
EP3587467A1 (de) * | 2018-06-25 | 2020-01-01 | Rudolf GmbH | Funktionelle mehrwandige kern-schale-partikel |
EP3813540A4 (en) * | 2018-06-28 | 2022-04-06 | Mars, Incorporated | ENHANCED EDIBLE INK FORMULATIONS INCLUDING CALCIUM CARBONATE |
KR102151342B1 (ko) * | 2019-03-18 | 2020-09-02 | 박문수 | 구강용 캡슐 및 이의 제조방법 |
CN110006918B (zh) * | 2019-04-17 | 2021-04-30 | 湖北三环锻造有限公司 | 一种用于渗透探伤工艺的渗透探伤剂 |
US10945953B1 (en) * | 2019-09-12 | 2021-03-16 | Nulixir Inc. | Controlled release core-shell particles and suspensions including the same |
EP4181912A1 (en) | 2020-07-15 | 2023-05-24 | Schabar Research Associates LLC | Unit oral dose compositions composed of ibuprofen and famotidine for the treatment of acute pain and the reduction of the severity and/or risk of heartburn |
CA3124579A1 (en) | 2020-07-15 | 2022-01-15 | Schabar Research Associates Llc | Unit oral dose compositions composed of naproxen sodium and famotidine for the treatment of acute pain and the reduction of the severity of heartburn and/or the risk of heartburn |
Family Cites Families (439)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US542614A (en) * | 1895-07-09 | Office | ||
US599865A (en) * | 1898-03-01 | Emanuel l | ||
US231117A (en) * | 1880-08-10 | Folding boat | ||
US231129A (en) * | 1880-08-10 | wiesebrook | ||
US231024A (en) * | 1880-08-10 | Machine for lining sheets of straw-board | ||
US582438A (en) | 1897-05-11 | John scheidler | ||
US231163A (en) * | 1880-08-17 | hamlin | ||
US3371136A (en) * | 1968-02-27 | United States Borax Chem | Detergent tablet forming machine | |
US231062A (en) * | 1880-08-10 | Felt hat | ||
US966450A (en) * | 1909-06-18 | 1910-08-09 | John W S Jones | Couch or bed. |
US966509A (en) * | 1909-06-25 | 1910-08-09 | Charles A Wulf | Flushing-valve. |
US967414A (en) * | 1910-02-11 | 1910-08-16 | William W Hallam | Railway-rail. |
US966939A (en) * | 1910-05-02 | 1910-08-09 | James V Mitchell | Sash-lock. |
US996497A (en) * | 1911-03-30 | 1911-06-27 | Kokomo Sanitary Mfg Co | Tank-cover fastener. |
US1036647A (en) | 1911-06-19 | 1912-08-27 | St Louis Briquette Machine Company | Briquet-machine. |
US1437816A (en) | 1922-07-26 | 1922-12-05 | Howard S Paine | Process for preparing fondant or chocolate soft cream centers |
US1505827A (en) * | 1923-04-25 | 1924-08-19 | Villasenor Eduardo | Tablet-making machine |
US1900012A (en) * | 1925-09-04 | 1933-03-07 | Western Cartridge Co | Process of and apparatus for making wads |
US2307371A (en) * | 1941-08-13 | 1943-01-05 | Ray O Vac Co | Molding process |
US2415997A (en) * | 1946-01-12 | 1947-02-18 | John W Eldred | Article handling apparatus |
US2823789A (en) * | 1952-05-06 | 1958-02-18 | Gilman Engineering & Mfg Corp | Parts feeder ribbon |
US2996431A (en) * | 1953-12-16 | 1961-08-15 | Barry Richard Henry | Friable tablet and process for manufacturing same |
US2849965A (en) | 1954-04-15 | 1958-09-02 | John Holroyd & Company Ltd | Machines for use in the production of coated tablets and the like |
GB759081A (en) | 1954-04-15 | 1956-10-10 | John Holroyd And Company Ltd | Improvements relating to machines for the production of coated tablets and the like |
US2966431A (en) | 1956-03-24 | 1960-12-27 | Basf Ag | Separation of filter material from carbon black |
US2946298A (en) | 1957-11-13 | 1960-07-26 | Arthur Colton Company | Compression coating tablet press |
US2931276A (en) * | 1958-02-10 | 1960-04-05 | Jagenberg Werke Ag | Methods of and means for producing, processing, and for treating articles |
GB866681A (en) | 1958-05-22 | 1961-04-26 | May & Baker Ltd | N-substituted piperidines |
GB888038A (en) | 1959-12-16 | 1962-01-24 | William Warren Triggs C B E | Medicinal tablet |
GB936386A (en) | 1959-01-16 | 1963-09-11 | Wellcome Found | Pellets for supplying biologically active substances to ruminants |
US2963993A (en) | 1959-01-20 | 1960-12-13 | John Holroyd & Company Ltd | Machines for making coated tablets by compression |
US3096248A (en) | 1959-04-06 | 1963-07-02 | Rexall Drug & Chemical Company | Method of making an encapsulated tablet |
US3029752A (en) * | 1959-07-20 | 1962-04-17 | Stokes F J Corp | Tablet making machine |
GB972128A (en) * | 1960-01-21 | 1964-10-07 | Wellcome Found | Pellets for supplying biologically active substances to ruminants and the manufacture of such pellets |
GB990784A (en) * | 1960-05-23 | 1965-05-05 | Dunlop Rubber Co | Improvements in or relating to balls |
US3173876A (en) * | 1960-05-27 | 1965-03-16 | John C Zobrist | Cleaning methods and compositions |
GB994742A (en) | 1960-09-09 | 1965-06-10 | Wellcome Found | Pharmaceutical tablets containing anthelmintics, and the manufacture thereof |
US3108046A (en) | 1960-11-25 | 1963-10-22 | Smith Kline French Lab | Method of preparing high dosage sustained release tablet and product of this method |
NL271831A (zh) * | 1960-11-29 | |||
NL272604A (zh) | 1960-12-28 | |||
US3430535A (en) * | 1961-08-25 | 1969-03-04 | Independent Lock Co | Key cutter |
BE636865A (zh) * | 1962-08-31 | |||
US3185626A (en) | 1963-03-06 | 1965-05-25 | Sterling Drug Inc | Tablet coating method |
US3279995A (en) | 1963-05-31 | 1966-10-18 | Allen F Reid | Shaped pellets |
US3276586A (en) * | 1963-08-30 | 1966-10-04 | Rosaen Filter Co | Indicating means for fluid filters |
US3300063A (en) * | 1965-01-25 | 1967-01-24 | Mayer & Co Inc O | Vacuum gripping apparatus |
FR1603314A (en) * | 1965-02-23 | 1971-04-05 | Pharmaceutical tablets - having a core and a matrix material | |
US3328840A (en) * | 1965-04-23 | 1967-07-04 | Pentronix Inc | Powder compacting press |
US3279360A (en) | 1965-09-13 | 1966-10-18 | Miehle Goss Dexter Inc | Machine for printing on cylindrical articles |
US3330400A (en) | 1966-03-08 | 1967-07-11 | Miehle Goss Dexter Inc | Mechanism for transferring cylindrical articles |
GB1212535A (en) * | 1966-10-12 | 1970-11-18 | Shionogi & Co | Method and apparatus for producing molded article |
US3458968A (en) | 1966-11-16 | 1969-08-05 | Lester Gregory Jr | Dispensing and feed mechanism |
GB1144915A (en) | 1966-11-24 | 1969-03-12 | Armour Pharma | Improvements in or relating to pastille formulations |
US3546142A (en) * | 1967-01-19 | 1970-12-08 | Amicon Corp | Polyelectrolyte structures |
US3656518A (en) * | 1967-03-27 | 1972-04-18 | Perry Ind Inc | Method and apparatus for measuring and dispensing predetermined equal amounts of powdered material |
US3563170A (en) * | 1968-04-16 | 1971-02-16 | Reynolds Metals Co | Machine for marking the exterior cylindrical surfaces of cans in a continous nonidexing manner |
US3605479A (en) | 1968-05-08 | 1971-09-20 | Textron Inc | Forming press |
US3584114A (en) | 1968-05-22 | 1971-06-08 | Hoffmann La Roche | Free-flowing powders |
SE335202B (zh) | 1968-06-19 | 1971-05-17 | Aco Laekemedel Ab | |
US3541006A (en) * | 1968-07-03 | 1970-11-17 | Amicon Corp | Ultrafiltration process |
FR1581088A (zh) | 1968-07-17 | 1969-09-12 | ||
US3567043A (en) * | 1968-08-05 | 1971-03-02 | Sun Chemical Corp | Transfer assembly for use with container printing machines |
US3627583A (en) * | 1969-04-29 | 1971-12-14 | Sucrest Corp | Direct compression vehicles |
US3604417A (en) * | 1970-03-31 | 1971-09-14 | Wayne Henry Linkenheimer | Osmotic fluid reservoir for osmotically activated long-term continuous injector device |
US3640654A (en) * | 1970-06-25 | 1972-02-08 | Wolverine Pentronix | Die and punch assembly for compacting powder and method of assembly |
US3832252A (en) | 1970-09-29 | 1974-08-27 | T Higuchi | Method of making a drug-delivery device |
CH569482A5 (zh) | 1970-12-23 | 1975-11-28 | Boehringer Sohn Ingelheim | |
US3811552A (en) * | 1971-01-11 | 1974-05-21 | Lilly Co Eli | Capsule inspection apparatus and method |
US3760804A (en) * | 1971-01-13 | 1973-09-25 | Alza Corp | Improved osmotic dispenser employing magnesium sulphate and magnesium chloride |
US3995631A (en) * | 1971-01-13 | 1976-12-07 | Alza Corporation | Osmotic dispenser with means for dispensing active agent responsive to osmotic gradient |
US3726622A (en) | 1971-08-20 | 1973-04-10 | Wolverine Pentronix | Compacting apparatus |
DE2157465C3 (de) | 1971-11-19 | 1975-04-24 | Werner & Pfleiderer, 7000 Stuttgart | Füllvorrichtung für eine hydraulische Blockpresse |
GB1371244A (en) * | 1971-12-09 | 1974-10-23 | Howorth Air Conditioning Ltd | Machines acting on continuously running textile yarns |
BE794951A (fr) * | 1972-02-03 | 1973-05-29 | Parke Davis & Co | Conditionnement soluble dans l'eau |
US3851751A (en) | 1972-04-26 | 1974-12-03 | Jones & Co Inc R A | Method and apparatus for forming, filling and sealing packages |
US3975888A (en) | 1972-04-26 | 1976-08-24 | R. A. Jones & Company, Inc. | Method and apparatus for forming, filling and sealing packages |
US3845770A (en) * | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
US3912441A (en) | 1972-12-13 | 1975-10-14 | Yasuo Shimada | Compressing roll in rotary power compression molding machine |
US3851638A (en) | 1973-02-02 | 1974-12-03 | Kam Act Enterprises Inc | Force multiplying type archery bow |
DE2309202A1 (de) * | 1973-02-21 | 1974-08-29 | Schering Ag | Arzneiformen mit mikroverkapseltem arzneimittelwirkstoff |
US3832525A (en) * | 1973-03-26 | 1974-08-27 | Raymond Lee Organization Inc | Automatic heating device to prevent freezing of water supply lines |
US3916899A (en) * | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
US3884143A (en) * | 1973-09-04 | 1975-05-20 | Hartnett Co R W | Conveyor link for tablet printing apparatus |
DE2401419A1 (de) | 1974-01-12 | 1975-07-17 | Bosch Gmbh Robert | Fahrzeug mit einem hydrostatischen und mechanischen antrieb |
US3891375A (en) | 1974-01-21 | 1975-06-24 | Vector Corp | Tablet press |
GB1497044A (en) | 1974-03-07 | 1978-01-05 | Prodotti Antibiotici Spa | Salts of phenyl-alkanoic acids |
US3988403A (en) * | 1974-07-09 | 1976-10-26 | Union Carbide Corporation | Process for producing molded structural foam article having a surface that reproducibly and faithfully replicates the surface of the mold |
US4139589A (en) * | 1975-02-26 | 1979-02-13 | Monique Beringer | Process for the manufacture of a multi-zone tablet and tablet manufactured by this process |
US4230693A (en) * | 1975-04-21 | 1980-10-28 | Armour-Dial, Inc. | Antacid tablets and processes for their preparation |
FR2312247A1 (fr) * | 1975-05-30 | 1976-12-24 | Parcor | Derives de la thieno-pyridine, leur procede de preparation et leurs applications |
US4097606A (en) * | 1975-10-08 | 1978-06-27 | Bristol-Myers Company | APAP Tablet containing an alkali metal carboxymethylated starch and processes for manufacturing same |
US4077407A (en) * | 1975-11-24 | 1978-03-07 | Alza Corporation | Osmotic devices having composite walls |
SE414386B (sv) | 1976-03-10 | 1980-07-28 | Aco Laekemedel Ab | Sett att framstella och samtidigt forpacka farmaceutiska dosenheter |
GB1548022A (en) * | 1976-10-06 | 1979-07-04 | Wyeth John & Brother Ltd | Pharmaceutial dosage forms |
US4111202A (en) | 1976-11-22 | 1978-09-05 | Alza Corporation | Osmotic system for the controlled and delivery of agent over time |
US4218433A (en) | 1977-03-03 | 1980-08-19 | Nippon Kayaku Kabushiki Kaisha | Constant-rate eluting tablet and method of producing same |
US4139627A (en) * | 1977-10-06 | 1979-02-13 | Beecham Inc. | Anesthetic lozenges |
DE2752971C2 (de) * | 1977-11-28 | 1982-08-19 | Lev Nikolaevič Moskva Koškin | Spritzgießmaschine zum Herstellen von Spritzgußteilen aus thermoplastischen Werkstoffen |
GB2030042A (en) * | 1978-09-21 | 1980-04-02 | Beecham Group Ltd | Antacid fondant |
DE2849494A1 (de) * | 1978-11-15 | 1980-05-29 | Voss Gunter M | Verfahren zur herstellung von arzneimittel-formlingen |
US4173626A (en) * | 1978-12-11 | 1979-11-06 | Merck & Co., Inc. | Sustained release indomethacin |
US4198390A (en) | 1979-01-31 | 1980-04-15 | Rider Joseph A | Simethicone antacid tablet |
US4304232A (en) * | 1979-03-14 | 1981-12-08 | Alza Corporation | Unit system having multiplicity of means for dispensing useful agent |
US4286497A (en) * | 1979-06-18 | 1981-09-01 | Shamah Alfred A | Ratchet-securable toggle retainer |
US4271142A (en) * | 1979-06-18 | 1981-06-02 | Life Savers, Inc. | Portable liquid antacids |
JPS5827162B2 (ja) | 1979-08-24 | 1983-06-08 | 株式会社ヤクルト本社 | 定速搬送機構 |
DE2936040C2 (de) * | 1979-09-06 | 1982-05-19 | Meggle Milchindustrie Gmbh & Co Kg, 8094 Reitmehring | Dragierverfahren und Mittel zur Durchführung des Verfahrens, bestehend im wesentlichen aus Saccharose, wenigstens einem weiteren Zucker und Wasser |
NL7906689A (nl) * | 1979-09-06 | 1981-03-10 | Dawsonville Corp Nv | Tatoueerinrichting. |
US4271206A (en) * | 1979-10-26 | 1981-06-02 | General Foods Corporation | Gasified candy having a predetermined shape |
US4273793A (en) | 1979-10-26 | 1981-06-16 | General Foods Corporation | Apparatus and process for the preparation of gasified confectionaries by pressurized injection molding |
US4543370A (en) | 1979-11-29 | 1985-09-24 | Colorcon, Inc. | Dry edible film coating composition, method and coating form |
US4318746A (en) * | 1980-01-08 | 1982-03-09 | Ipco Corporation | Highly stable gel, its use and manufacture |
US4473526A (en) | 1980-01-23 | 1984-09-25 | Eugen Buhler | Method of manufacturing dry-pressed molded articles |
US4292017A (en) * | 1980-07-09 | 1981-09-29 | Doepel Wallace A | Apparatus for compressing tablets |
US4362757A (en) | 1980-10-22 | 1982-12-07 | Amstar Corporation | Crystallized, readily water dispersible sugar product containing heat sensitive, acidic or high invert sugar substances |
FR2492661A1 (fr) * | 1980-10-28 | 1982-04-30 | Laruelle Claude | Nouvelle forme galenique d'administration du metoclopramide, son procede de preparation et medicament comprenant cette nouvelle forme |
US4683256A (en) * | 1980-11-06 | 1987-07-28 | Colorcon, Inc. | Dry edible film coating composition, method and coating form |
US4327076A (en) * | 1980-11-17 | 1982-04-27 | Life Savers, Inc. | Compressed chewable antacid tablet and method for forming same |
US4327725A (en) * | 1980-11-25 | 1982-05-04 | Alza Corporation | Osmotic device with hydrogel driving member |
US4340054A (en) * | 1980-12-29 | 1982-07-20 | Alza Corporation | Dispenser for delivering fluids and solids |
US5002970A (en) * | 1981-07-31 | 1991-03-26 | Eby Iii George A | Flavor masked ionizable zinc compositions for oral absorption |
IE53102B1 (en) * | 1981-05-12 | 1988-06-22 | Ici Plc | Pharmaceutical spiro-succinimide derivatives |
US4372942A (en) * | 1981-08-13 | 1983-02-08 | Beecham Inc. | Candy base and liquid center hard candy made therefrom |
DE3144678A1 (de) * | 1981-11-10 | 1983-05-19 | Eugen Dipl.-Ing. 8871 Burtenbach Bühler | Verfahren und einrichtung zur herstellung von formlingen aus einer rieselfaehigen masse |
JPS58152813A (ja) | 1982-03-08 | 1983-09-10 | Sumitomo Chem Co Ltd | 鮮明な刻印を有する錠剤およびその製法 |
US4449983A (en) | 1982-03-22 | 1984-05-22 | Alza Corporation | Simultaneous delivery of two drugs from unit delivery device |
DK151608C (da) * | 1982-08-13 | 1988-06-20 | Benzon As Alfred | Fremgangsmaade til fremstilling af et farmaceutisk peroralt polydepotpraeparat med kontrolleret afgivelse |
US4517205A (en) | 1983-01-03 | 1985-05-14 | Nabisco Brands, Inc. | Co-deposited two-component hard candy |
US4576604A (en) | 1983-03-04 | 1986-03-18 | Alza Corporation | Osmotic system with instant drug availability |
US4882167A (en) | 1983-05-31 | 1989-11-21 | Jang Choong Gook | Dry direct compression compositions for controlled release dosage forms |
US4533345A (en) * | 1983-06-14 | 1985-08-06 | Fertility & Genetics Associates | Uterine catheter |
FR2548675B1 (fr) * | 1983-07-06 | 1987-01-09 | Seppic Sa | Compositions filmogenes pour enrobage des formes solides de produits pharmaceutiques ou alimentaires et produits obtenus revetus desdites compositions |
US4749575A (en) * | 1983-10-03 | 1988-06-07 | Bio-Dar Ltd. | Microencapsulated medicament in sweet matrix |
US4781714A (en) | 1983-11-02 | 1988-11-01 | Alza Corporation | Dispenser for delivering thermo-responsive composition |
AU591171B2 (en) | 1983-11-02 | 1989-11-30 | Alza Corporation | Dispenser for delivering thermo-responsive composition |
NL194820C (nl) | 1983-11-02 | 2003-04-03 | Alza Corp | Preparaat voor de afgifte van een op warmte reagerende samenstelling. |
DE3404108A1 (de) | 1984-02-07 | 1985-08-14 | Kilian & Co GmbH, 5000 Köln | Tablettenpresse |
US4518335A (en) | 1984-03-14 | 1985-05-21 | Allied Corporation | Dilatant mold and dilatant molding apparatus |
US4564525A (en) * | 1984-03-30 | 1986-01-14 | Mitchell Cheryl R | Confection products |
JPS60217106A (ja) | 1984-04-12 | 1985-10-30 | 高橋 信之 | 無機粉末凍結成形法 |
US4661521A (en) * | 1984-04-30 | 1987-04-28 | Mallinckrodt, Inc. | Direct tableting acetaminophen compositions |
US4528335A (en) * | 1984-05-18 | 1985-07-09 | Phillips Petroleum Company | Polymer blends |
US4666212A (en) * | 1984-06-15 | 1987-05-19 | Crucible S.A. | Metal value recovery |
US4610884A (en) * | 1984-06-29 | 1986-09-09 | The Procter & Gamble Company | Confectionery cremes |
US4828841A (en) | 1984-07-24 | 1989-05-09 | Colorcon, Inc. | Maltodextrin coating |
US4643894A (en) | 1984-07-24 | 1987-02-17 | Colorcon, Inc. | Maltodextrin coating |
US4894234A (en) * | 1984-10-05 | 1990-01-16 | Sharma Shri C | Novel drug delivery system for antiarrhythmics |
JPS61100519A (ja) * | 1984-10-23 | 1986-05-19 | Shin Etsu Chem Co Ltd | 医薬用硬質カプセル |
US4684534A (en) * | 1985-02-19 | 1987-08-04 | Dynagram Corporation Of America | Quick-liquifying, chewable tablet |
US4874614A (en) * | 1985-03-25 | 1989-10-17 | Abbott Laboratories | Pharmaceutical tableting method |
US4627971A (en) * | 1985-04-22 | 1986-12-09 | Alza Corporation | Osmotic device with self-sealing passageway |
CA1234717A (en) * | 1985-06-28 | 1988-04-05 | Leslie F. Knebl | Moist chewing gum composition |
GB8517073D0 (en) | 1985-07-05 | 1985-08-14 | Hepworth Iron Co Ltd | Pipe pipe couplings &c |
GB8518301D0 (en) * | 1985-07-19 | 1985-08-29 | Fujisawa Pharmaceutical Co | Hydrodynamically explosive systems |
DK8603837A (zh) * | 1985-08-13 | 1987-02-14 | ||
US4665116A (en) | 1985-08-28 | 1987-05-12 | Turtle Wax, Inc. | Clear cleaner/polish composition |
US4663147A (en) | 1985-09-03 | 1987-05-05 | International Minerals & Chemical Corp. | Disc-like sustained release formulation |
US5188840A (en) * | 1985-09-26 | 1993-02-23 | Chugai Seiyaku Kabushiki Kaisha | Slow-release pharmaceutical agent |
US4898733A (en) * | 1985-11-04 | 1990-02-06 | International Minerals & Chemical Corp. | Layered, compression molded device for the sustained release of a beneficial agent |
US4853249A (en) | 1985-11-15 | 1989-08-01 | Taisho Pharmaceutical Co., Ltd. | Method of preparing sustained-release pharmaceutical/preparation |
US5229164A (en) * | 1985-12-19 | 1993-07-20 | Capsoid Pharma Gmbh | Process for producing individually dosed administration forms |
DE3601516A1 (de) * | 1986-01-20 | 1987-07-23 | Agie Ag Ind Elektronik | Lichtschranke |
JPS62230600A (ja) | 1986-03-31 | 1987-10-09 | 東洋ゴム工業株式会社 | 伸縮可能なフオ−クを備えたフオ−クリフト |
DE3610878A1 (de) | 1986-04-01 | 1987-10-08 | Boehringer Ingelheim Kg | Formlinge aus pellets |
US4873231A (en) | 1986-04-08 | 1989-10-10 | Smith Walton J | Decreasing the toxicity of an ibuprofen salt |
SE8601624D0 (sv) * | 1986-04-11 | 1986-04-11 | Haessle Ab | New pharmaceutical preparations |
US4857330A (en) * | 1986-04-17 | 1989-08-15 | Alza Corporation | Chlorpheniramine therapy |
GB2189698A (en) | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated omeprazole tablets |
US4960416A (en) * | 1986-04-30 | 1990-10-02 | Alza Corporation | Dosage form with improved delivery capability |
GB2189699A (en) | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated acid-labile medicaments |
US5200196A (en) * | 1986-05-09 | 1993-04-06 | Alza Corporation | Improvement in pulsed drug therapy |
US4802924A (en) | 1986-06-19 | 1989-02-07 | Colorcon, Inc. | Coatings based on polydextrose for aqueous film coating of pharmaceutical food and confectionary products |
IE58401B1 (en) * | 1986-06-20 | 1993-09-08 | Elan Corp Plc | Controlled absorption pharmaceutical composition |
US4757090A (en) * | 1986-07-14 | 1988-07-12 | Mallinckrodt, Inc. | Direct tableting acetaminophen compositions |
US4762719A (en) | 1986-08-07 | 1988-08-09 | Mark Forester | Powder filled cough product |
US4816262A (en) | 1986-08-28 | 1989-03-28 | Universite De Montreal | Controlled release tablet |
DE3629994A1 (de) | 1986-09-03 | 1988-03-17 | Weissenbacher Ernst Rainer Pro | Vorrichtung zur medikamentenapplikation in koerperhoehlen bzw. auf koerperoberflaechen |
US4803076A (en) | 1986-09-04 | 1989-02-07 | Pfizer Inc. | Controlled release device for an active substance |
CA1290526C (en) | 1986-11-07 | 1991-10-15 | Marianne Wieser | Mold and die operation |
DE3640574A1 (de) * | 1986-11-27 | 1988-06-09 | Katjes Fassin Gmbh & Co Kg | Verfahren zur herstellung eines essbaren pralinenfoermigen produktes und vorrichtung fuer die durchfuehrung des verfahrens |
US4828845A (en) * | 1986-12-16 | 1989-05-09 | Warner-Lambert Company | Xylitol coated comestible and method of preparation |
IT1201136B (it) | 1987-01-13 | 1989-01-27 | Resa Farma | Compressa per uso farmaceutico atta al rilascio in tempi successivi di sostanze attive |
US4801461A (en) * | 1987-01-28 | 1989-01-31 | Alza Corporation | Pseudoephedrine dosage form |
US4820524A (en) * | 1987-02-20 | 1989-04-11 | Mcneilab, Inc. | Gelatin coated caplets and process for making same |
US5200193A (en) | 1987-04-22 | 1993-04-06 | Mcneilab, Inc. | Pharmaceutical sustained release matrix and process |
US4808413A (en) * | 1987-04-28 | 1989-02-28 | E. R. Squibb & Sons, Inc. | Pharmaceutical compositions in the form of beadlets and method |
US4792448A (en) | 1987-06-11 | 1988-12-20 | Pfizer Inc. | Generic zero order controlled drug delivery system |
US4813818A (en) * | 1987-08-25 | 1989-03-21 | Michael Sanzone | Apparatus and method for feeding powdered materials |
US4978483A (en) | 1987-09-28 | 1990-12-18 | Redding Bruce K | Apparatus and method for making microcapsules |
US4996061A (en) * | 1987-10-07 | 1991-02-26 | Merrell Dow Pharmaceuticals Inc. | Pharmaceutical composition for piperidinoalkanol-decongestant combination |
US4851226A (en) * | 1987-11-16 | 1989-07-25 | Mcneil Consumer Products Company | Chewable medicament tablet containing means for taste masking |
US4894236A (en) * | 1988-01-12 | 1990-01-16 | Choong-Gook Jang | Direct compression tablet binders for acetaminophen |
CA1330886C (en) | 1988-01-22 | 1994-07-26 | Bend Research Inc. | Osmotic system for delivery of dilute solutions |
CH676470A5 (zh) * | 1988-02-03 | 1991-01-31 | Nestle Sa | |
US4929446A (en) | 1988-04-19 | 1990-05-29 | American Cyanamid Company | Unit dosage form |
US5279660A (en) * | 1988-05-24 | 1994-01-18 | Berol Nobel Stenungsund Ab | Use of viscosity-adjusting agent to counteract viscosity decrease upon temperature increase of a water-based system |
US4999226A (en) | 1988-06-01 | 1991-03-12 | Merrell Dow Pharmaceuticals Inc. | Pharmaceutical compositions for piperidinoalkanol-ibuprofen combination |
DE3822095A1 (de) * | 1988-06-30 | 1990-01-04 | Klinge Co Chem Pharm Fab | Neue arzneimittelformulierung sowie verfahren zu deren herstellung |
GB8820353D0 (en) * | 1988-08-26 | 1988-09-28 | Staniforth J N | Controlled release tablet |
WO1990002546A1 (en) * | 1988-09-09 | 1990-03-22 | The Ronald T. Dodge Company | Pharmaceuticals microencapsulated by vapor deposited polymers and method |
US5194464A (en) * | 1988-09-27 | 1993-03-16 | Takeda Chemical Industries, Ltd. | Enteric film and preparatoin thereof |
JPH0816051B2 (ja) | 1988-12-07 | 1996-02-21 | エスエス製薬株式会社 | 徐放性坐剤 |
US4906478A (en) | 1988-12-12 | 1990-03-06 | Valentine Enterprises, Inc. | Simethicone/calcium silicate composition |
US4984240A (en) | 1988-12-22 | 1991-01-08 | Codex Corporation | Distributed switching architecture for communication module redundancy |
US5610214A (en) | 1988-12-29 | 1997-03-11 | Deknatel Technology Corporation, Inc. | Method for increasing the rate of absorption of polycaprolactone |
IL92966A (en) * | 1989-01-12 | 1995-07-31 | Pfizer | Hydrogel-operated release devices |
US5030452A (en) * | 1989-01-12 | 1991-07-09 | Pfizer Inc. | Dispensing devices powered by lyotropic liquid crystals |
US5032406A (en) * | 1989-02-21 | 1991-07-16 | Norwich Eaton Pharmaceuticals, Inc. | Dual-action tablet |
US5006297A (en) * | 1989-02-22 | 1991-04-09 | Acushnet Company | Method of molding polyurethane covered golf balls |
US4956182A (en) | 1989-03-16 | 1990-09-11 | Bristol-Myers Company | Direct compression cholestyramine tablet and solvent-free coating therefor |
US4931286A (en) * | 1989-04-19 | 1990-06-05 | Aqualon Company | High gloss cellulose tablet coating |
NZ233403A (en) * | 1989-04-28 | 1992-09-25 | Mcneil Ppc Inc | Simulated capsule-like medicament |
US4990535A (en) * | 1989-05-03 | 1991-02-05 | Schering Corporation | Pharmaceutical composition comprising loratadine, ibuprofen and pseudoephedrine |
US4960169A (en) * | 1989-06-20 | 1990-10-02 | Modien Manufacturing Co. | Baffle for tubular heat exchanger header |
US4992277A (en) * | 1989-08-25 | 1991-02-12 | Schering Corporation | Immediate release diltiazem formulation |
EP0419410A3 (en) | 1989-09-19 | 1991-08-14 | Ciba-Geigy Ag | Alkanophenones |
US5146730A (en) | 1989-09-20 | 1992-09-15 | Banner Gelatin Products Corp. | Film-enrobed unitary-core medicament and the like |
DK469989D0 (da) | 1989-09-22 | 1989-09-22 | Bukh Meditec | Farmaceutisk praeparat |
US5178878A (en) * | 1989-10-02 | 1993-01-12 | Cima Labs, Inc. | Effervescent dosage form with microparticles |
US5223264A (en) * | 1989-10-02 | 1993-06-29 | Cima Labs, Inc. | Pediatric effervescent dosage form |
US5275822A (en) * | 1989-10-19 | 1994-01-04 | Valentine Enterprises, Inc. | Defoaming composition |
JPH03139496A (ja) * | 1989-10-25 | 1991-06-13 | Sanshin Ind Co Ltd | 船舶推進機 |
US5169645A (en) | 1989-10-31 | 1992-12-08 | Duquesne University Of The Holy Ghost | Directly compressible granules having improved flow properties |
FR2655266B1 (fr) * | 1989-12-05 | 1992-04-03 | Smith Kline French Lab | Compositions pharmaceutiques a base de cimetidine. |
US5223266A (en) | 1990-01-24 | 1993-06-29 | Alza Corporation | Long-term delivery device with early startup |
US5100676A (en) * | 1990-02-02 | 1992-03-31 | Biosurface Technology, Inc. | Cool storage of cultured epithelial sheets |
US5158777A (en) * | 1990-02-16 | 1992-10-27 | E. R. Squibb & Sons, Inc. | Captopril formulation providing increased duration of activity |
US4980169A (en) | 1990-05-03 | 1990-12-25 | Warner-Lambert Company | Flavor enhancing and increasing efficacy of cough drops |
US4983394A (en) * | 1990-05-03 | 1991-01-08 | Warner-Lambert Company | Flavor enhancing and medicinal taste masking agent |
US5089270A (en) * | 1990-05-15 | 1992-02-18 | L. Perrigo Company | Capsule-shaped tablet |
US5213738A (en) * | 1990-05-15 | 1993-05-25 | L. Perrigo Company | Method for making a capsule-shaped tablet |
US5075114A (en) | 1990-05-23 | 1991-12-24 | Mcneil-Ppc, Inc. | Taste masking and sustained release coatings for pharmaceuticals |
US5464631A (en) | 1990-06-27 | 1995-11-07 | Warner-Lambert Company | Encapsulated dosage forms |
US5133892A (en) | 1990-10-17 | 1992-07-28 | Lever Brothers Company, Division Of Conopco, Inc. | Machine dishwashing detergent tablets |
US5538125A (en) | 1990-11-05 | 1996-07-23 | Mcneil-Ppc, Inc. | Indexing and feeding systems for apparatus for gelatin coating tablets |
US5503673A (en) * | 1990-11-05 | 1996-04-02 | Mcneil-Ppc, Inc | Apparatus for dip coating product |
US5436026A (en) | 1990-11-05 | 1995-07-25 | Mcneil-Ppc, Inc. | Discharge and transfer system for apparatus for gelatin coating tablets |
US5228916A (en) * | 1990-11-05 | 1993-07-20 | Mcneil-Ppc, Inc. | Apparatus for creating a gelatin coating |
US5683719A (en) * | 1990-11-22 | 1997-11-04 | British Technology Group Limited | Controlled release compositions |
US5098715A (en) * | 1990-12-20 | 1992-03-24 | Burroughs Wellcome Co. | Flavored film-coated tablet |
US5232706A (en) | 1990-12-31 | 1993-08-03 | Esteve Quimica, S.A. | Oral pharmaceutical preparation containing omeprazol |
DE4101873C2 (de) * | 1991-01-23 | 1993-12-09 | Isis Pharma Gmbh | Peroral applizierbare Arzneiform zur Behandlung zentraler Dopaminmangelzustände |
US5378475A (en) | 1991-02-21 | 1995-01-03 | University Of Kentucky Research Foundation | Sustained release drug delivery devices |
NZ241613A (en) * | 1991-02-27 | 1993-06-25 | Janssen Pharmaceutica Nv | Highlighting intagliations in tablets |
CA2061520C (en) | 1991-03-27 | 2003-04-22 | Lawrence J. Daher | Delivery system for enhanced onset and increased potency |
US5286497A (en) * | 1991-05-20 | 1994-02-15 | Carderm Capital L.P. | Diltiazem formulation |
CA2068402C (en) * | 1991-06-14 | 1998-09-22 | Michael R. Hoy | Taste mask coatings for preparation of chewable pharmaceutical tablets |
YU48263B (sh) | 1991-06-17 | 1997-09-30 | Byk Gulden Lomberg Chemische Fabrik Gmbh. | Postupak za dobijanje farmaceutskog preparata na bazi pantoprazola |
US5252338A (en) * | 1991-06-27 | 1993-10-12 | Alza Corporation | Therapy delayed |
US5314696A (en) * | 1991-06-27 | 1994-05-24 | Paulos Manley A | Methods for making and administering a blinded oral dosage form and blinded oral dosage form therefor |
US5190927A (en) * | 1991-07-09 | 1993-03-02 | Merck & Co., Inc. | High-glyceryl, low-acetyl gellan gum for non-brittle gels |
US5326570A (en) * | 1991-07-23 | 1994-07-05 | Pharmavene, Inc. | Advanced drug delivery system and method of treating psychiatric, neurological and other disorders with carbamazepine |
US5200191A (en) * | 1991-09-11 | 1993-04-06 | Banner Gelatin Products Corp. | Softgel manufacturing process |
US5405617A (en) | 1991-11-07 | 1995-04-11 | Mcneil-Ppc, Inc. | Aliphatic or fatty acid esters as a solventless carrier for pharmaceuticals |
US5407686A (en) * | 1991-11-27 | 1995-04-18 | Sidmak Laboratories, Inc. | Sustained release composition for oral administration of active ingredient |
US5200195A (en) | 1991-12-06 | 1993-04-06 | Alza Corporation | Process for improving dosage form delivery kinetics |
DK171536B1 (da) | 1991-12-06 | 1996-12-23 | Rasmussen Kann Ind As | Vindue med ramme af ekstruderede profilemner |
US5200194A (en) * | 1991-12-18 | 1993-04-06 | Alza Corporation | Oral osmotic device |
GB2284760B (en) | 1993-11-23 | 1998-06-24 | Euro Celtique Sa | A method of preparing pharmaceutical compositions by melt pelletisation |
AU674840B2 (en) | 1992-01-17 | 1997-01-16 | Bpsi Holdings, Inc. | Film coatings and film coating compositions based on cellulosic polymers and lactose |
US5427614A (en) | 1992-02-14 | 1995-06-27 | Warner-Lambert Company | Starch based formulations |
US5209746A (en) * | 1992-02-18 | 1993-05-11 | Alza Corporation | Osmotically driven delivery devices with pulsatile effect |
US5221278A (en) * | 1992-03-12 | 1993-06-22 | Alza Corporation | Osmotically driven delivery device with expandable orifice for pulsatile delivery effect |
US5656296A (en) * | 1992-04-29 | 1997-08-12 | Warner-Lambert Company | Dual control sustained release drug delivery systems and methods for preparing same |
US5260068A (en) * | 1992-05-04 | 1993-11-09 | Anda Sr Pharmaceuticals Inc. | Multiparticulate pulsatile drug delivery system |
GR1002332B (el) | 1992-05-21 | 1996-05-16 | Mcneil-Ppc Inc. | Νεες φαρμακευτικες συνθεσεις που περιεχουν σιμεθεικονη. |
EP0572731A1 (en) | 1992-06-01 | 1993-12-08 | The Procter & Gamble Company | Chewable preparation containing a decongestant |
US5317849A (en) * | 1992-08-07 | 1994-06-07 | Sauter Manufacturing Corporation | Encapsulation equipment and method |
IT1255522B (it) * | 1992-09-24 | 1995-11-09 | Ubaldo Conte | Compressa per impiego terapeutico atta a cedere una o piu' sostanze attive con differenti velocita' |
JPH07507564A (ja) | 1992-09-30 | 1995-08-24 | ファイザー・インク. | コア及び厚さが一定でないコーティングを含有する物品 |
EP0670716B1 (en) * | 1992-11-30 | 2003-03-26 | Kv Pharmaceutical Company | Tastemasked pharmaceutical materials |
US5375963A (en) | 1993-01-19 | 1994-12-27 | Wohlwend; Clayton E. | Multipurpose lifting apparatus |
TW272942B (zh) | 1993-02-10 | 1996-03-21 | Takeda Pharm Industry Co Ltd | |
US5391378A (en) * | 1993-02-22 | 1995-02-21 | Elizabeth-Hata International, Inc. | Two-part medicinal tablet and method of manufacture |
JP2524955B2 (ja) | 1993-04-22 | 1996-08-14 | トーワ株式会社 | 電子部品の樹脂封止成形方法及び装置 |
EP0621032B1 (en) * | 1993-04-23 | 2000-08-09 | Novartis AG | Controlled release drug delivery device |
NZ260408A (en) | 1993-05-10 | 1996-05-28 | Euro Celtique Sa | Controlled release preparation comprising tramadol |
US5415868A (en) * | 1993-06-09 | 1995-05-16 | L. Perrigo Company | Caplets with gelatin cover and process for making same |
JP3054989B2 (ja) * | 1993-06-19 | 2000-06-19 | 八幡 貞男 | 断熱発現容器 |
IT1264855B1 (it) * | 1993-06-21 | 1996-10-17 | Zambon Spa | Composizioni farmaceutiche contenenti sali dell'acido s(+)-2-(4-isobutilfenil) propionico con amminoacidi basici |
ZA944949B (en) | 1993-07-12 | 1995-04-05 | Smithkline Beecham Corp | Matrix-entrapped beadlet preparation |
AU680019B2 (en) | 1993-08-30 | 1997-07-17 | Warner-Lambert Company Llc | Tablet coating based on a melt-spun mixture of a saccharide and apolymer |
US5518551A (en) * | 1993-09-10 | 1996-05-21 | Fuisz Technologies Ltd. | Spheroidal crystal sugar and method of making |
US5622719A (en) * | 1993-09-10 | 1997-04-22 | Fuisz Technologies Ltd. | Process and apparatus for making rapidly dissolving dosage units and product therefrom |
US5397574A (en) * | 1993-10-04 | 1995-03-14 | Andrx Pharmaceuticals, Inc. | Controlled release potassium dosage form |
US5433951A (en) * | 1993-10-13 | 1995-07-18 | Bristol-Myers Squibb Company | Sustained release formulation containing captopril and method |
US5500227A (en) * | 1993-11-23 | 1996-03-19 | Euro-Celtique, S.A. | Immediate release tablet cores of insoluble drugs having sustained-release coating |
DE4341442C2 (de) * | 1993-12-04 | 1998-11-05 | Lohmann Therapie Syst Lts | Vorrichtung zur kontrollierten Freisetzung von Wirkstoffen sowie ihre Verwendung |
US5458887A (en) * | 1994-03-02 | 1995-10-17 | Andrx Pharmaceuticals, Inc. | Controlled release tablet formulation |
US6060639A (en) * | 1994-03-04 | 2000-05-09 | Mentor Corporation | Testicular prosthesis and method of manufacturing and filling |
US5453920A (en) * | 1994-03-08 | 1995-09-26 | Eubanks; William W. | Trouble light having a shroud with see-through opening |
US5559110A (en) | 1994-03-09 | 1996-09-24 | The Dupont Merck Pharmaceutical Company | Pharmaceutical formulations of cyclic urea type compounds |
JPH07281423A (ja) * | 1994-04-07 | 1995-10-27 | Konica Corp | 印刷版の製版方法 |
US5464633A (en) | 1994-05-24 | 1995-11-07 | Jagotec Ag | Pharmaceutical tablets releasing the active substance after a definite period of time |
US6020002A (en) * | 1994-06-14 | 2000-02-01 | Fuisz Technologies Ltd. | Delivery of controlled-release system(s) |
SE9402431D0 (sv) | 1994-07-08 | 1994-07-08 | Astra Ab | New tablet formulation |
DK0723436T3 (da) | 1994-07-08 | 2001-11-26 | Astrazeneca Ab | Tabletteret flerenhedsdoseringsform |
US5788979A (en) * | 1994-07-22 | 1998-08-04 | Inflow Dynamics Inc. | Biodegradable coating with inhibitory properties for application to biocompatible materials |
IT1274034B (it) * | 1994-07-26 | 1997-07-14 | Applied Pharma Res | Composizioni farmaceutiche a base di gomma da masticare e procedimento per la loro preparazione |
US5849327A (en) | 1994-07-29 | 1998-12-15 | Advanced Polymer Systems, Inc. | Delivery of drugs to the lower gastrointestinal tract |
US6177125B1 (en) * | 1994-08-03 | 2001-01-23 | Gunter M. Voss | Method of producing coated tablets |
DE9414065U1 (de) * | 1994-08-31 | 1994-11-03 | Roehm Gmbh | Thermoplastischer Kunststoff für darmsaftlösliche Arznei-Umhüllungen |
DE4431653C2 (de) | 1994-09-06 | 2000-01-20 | Lohmann Therapie Syst Lts | Manteltablette zur kontrollierten Freisetzung von Wirkstoffen, ein Verfahren zu ihrer Herstellung und ihre Verwendung |
US5733575A (en) * | 1994-10-07 | 1998-03-31 | Bpsi Holdings, Inc. | Enteric film coating compositions, method of coating therewith, and coated forms |
CA2134611C (en) * | 1994-10-28 | 2002-12-24 | Richard John Yarwood | Process for preparing solid pharmaceutical dosage forms |
US5614578A (en) | 1994-10-28 | 1997-03-25 | Alza Corporation | Injection-molded dosage form |
US5593696A (en) | 1994-11-21 | 1997-01-14 | Mcneil-Ppc, Inc. | Stabilized composition of famotidine and sucralfate for treatment of gastrointestinal disorders |
US5756123A (en) * | 1994-12-01 | 1998-05-26 | Japan Elanco Co., Ltd. | Capsule shell |
US5626896A (en) * | 1994-12-09 | 1997-05-06 | A.E. Staley Manufacturing Co. | Method for making liquid-centered jelly candies |
US5582838A (en) * | 1994-12-22 | 1996-12-10 | Merck & Co., Inc. | Controlled release drug suspension delivery device |
DE4446468A1 (de) * | 1994-12-23 | 1996-06-27 | Basf Ag | Verfahren zur Herstellung von umhüllten Tabletten |
US6471994B1 (en) * | 1995-01-09 | 2002-10-29 | Edward Mendell Co., Inc. | Pharmaceutical excipient having improved compressibility |
ES2094694B1 (es) | 1995-02-01 | 1997-12-16 | Esteve Quimica Sa | Nueva formulacion farmaceuticamente estable de un compuesto de bencimidazol y su proceso de obtencion. |
ES2124956T3 (es) * | 1995-02-07 | 1999-02-16 | Hermann Kronseder | Estrella de transporte para recipientes. |
SE9500478D0 (sv) | 1995-02-09 | 1995-02-09 | Astra Ab | New pharmaceutical formulation and process |
US5558879A (en) * | 1995-04-28 | 1996-09-24 | Andrx Pharmaceuticals, Inc. | Controlled release formulation for water soluble drugs in which a passageway is formed in situ |
US5736159A (en) * | 1995-04-28 | 1998-04-07 | Andrx Pharmaceuticals, Inc. | Controlled release formulation for water insoluble drugs in which a passageway is formed in situ |
US5827874A (en) | 1995-05-05 | 1998-10-27 | Meyer; Hans | Methods of treating pain and inflammation with proline |
ES2194100T3 (es) * | 1995-05-09 | 2003-11-16 | Phoqus Ltd | Revestimiento electrostatico. |
ES2129902T3 (es) * | 1995-05-13 | 1999-06-16 | Hermann Kronseder | Rueda transportadora en estrella para recipientes. |
US5627971A (en) * | 1995-06-01 | 1997-05-06 | Northern Telecom Limited | Machine method for determining the eligibility of links in a network |
US5578336A (en) * | 1995-06-07 | 1996-11-26 | Monte; Woodrow C. | Confection carrier for vitamins, enzymes, phytochemicals and ailmentary vegetable compositions and method of making |
US5654005A (en) | 1995-06-07 | 1997-08-05 | Andrx Pharmaceuticals, Inc. | Controlled release formulation having a preformed passageway |
EP0833621B1 (en) * | 1995-06-09 | 2002-01-30 | R.P. Scherer Technologies, Inc. | Soft gelatin capsules containing particulate material |
US5614207A (en) | 1995-06-30 | 1997-03-25 | Mcneil-Ppc, Inc. | Dry mouth lozenge |
GB9517031D0 (en) * | 1995-08-19 | 1995-10-25 | Procter & Gamble | Confection compositions |
CZ293595B6 (cs) | 1995-09-21 | 2004-06-16 | Pharma Pass Llc | Orální kompozice na bázi omeprazolu a způsob její přípravy |
AUPN605795A0 (en) * | 1995-10-19 | 1995-11-09 | F.H. Faulding & Co. Limited | Analgesic pharmaceutical composition |
DE19539361A1 (de) | 1995-10-23 | 1997-04-24 | Basf Ag | Verfahren zur Herstellung von mehrschichtigen, festen Arzneiformen zur oralen oder rektalen Verabreichung |
IT1279673B1 (it) * | 1995-11-07 | 1997-12-16 | Acma Spa | Apparecchiatura e metodo per la formazione di gruppi ordinati di prodotti da alimentare a passo. |
US5733578A (en) * | 1995-11-15 | 1998-03-31 | Edward Mendell Co., Inc. | Directly compressible high load acetaminophen formulations |
US5807579A (en) * | 1995-11-16 | 1998-09-15 | F.H. Faulding & Co. Limited | Pseudoephedrine combination pharmaceutical compositions |
JP3220373B2 (ja) * | 1995-11-28 | 2001-10-22 | バイエル薬品株式会社 | 持続性ニフエジピン製剤 |
US6489346B1 (en) | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
SE9600070D0 (sv) | 1996-01-08 | 1996-01-08 | Astra Ab | New oral pharmaceutical dosage forms |
SE9600071D0 (sv) * | 1996-01-08 | 1996-01-08 | Astra Ab | New oral formulation of two active ingredients I |
US5879728A (en) * | 1996-01-29 | 1999-03-09 | Warner-Lambert Company | Chewable confectionary composition and method of preparing same |
IT1282576B1 (it) | 1996-02-06 | 1998-03-31 | Jagotec Ag | Compressa farmaceutica atta a cedere la sostanza attiva in tempi successivi e predeterminabili |
US6245351B1 (en) * | 1996-03-07 | 2001-06-12 | Takeda Chemical Industries, Ltd. | Controlled-release composition |
US5711691A (en) * | 1996-05-13 | 1998-01-27 | Air Packaging Technologies, Inc. | Self-closing and self-sealing valve device for use with inflatable structures |
US5827535A (en) | 1996-06-21 | 1998-10-27 | Banner Pharmacaps, Inc. | Graphically impressed softgel and method for making same |
US5797898A (en) | 1996-07-02 | 1998-08-25 | Massachusetts Institute Of Technology | Microchip drug delivery devices |
US5824338A (en) * | 1996-08-19 | 1998-10-20 | L. Perrigo Company | Caplet and gelatin covering therefor |
US5916881A (en) * | 1996-10-07 | 1999-06-29 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | High trehalose content syrup |
US5807580A (en) | 1996-10-30 | 1998-09-15 | Mcneil-Ppc, Inc. | Film coated tablet compositions having enhanced disintegration characteristics |
US6077539A (en) | 1996-11-12 | 2000-06-20 | Pozen, Inc. | Treatment of migraine headache |
GB9624110D0 (en) * | 1996-11-20 | 1997-01-08 | Molins Plc | Transferring rod like articles |
US5830801A (en) * | 1997-01-02 | 1998-11-03 | Motorola, Inc. | Resistless methods of gate formation in MOS devices |
DE19710213A1 (de) | 1997-03-12 | 1998-09-17 | Basf Ag | Verfahren zur Herstellung von festen Kombinationsarzneiformen |
US5837301A (en) | 1997-04-28 | 1998-11-17 | Husky Injection Molding Systems Ltd. | Injection molding machine having a high speed turret |
US6210710B1 (en) * | 1997-04-28 | 2001-04-03 | Hercules Incorporated | Sustained release polymer blend for pharmaceutical applications |
US6149939A (en) * | 1997-05-09 | 2000-11-21 | Strumor; Mathew A. | Healthful dissolvable oral tablets, and mini-bars |
JP2001524131A (ja) | 1997-05-09 | 2001-11-27 | セイジ、ファーマスーティカルズ、インク | 安定な経口医薬品剤形 |
WO1999000122A1 (de) * | 1997-06-25 | 1999-01-07 | Ipr-Institute For Pharmaceutical Research Ag | Verfahren zur reduktion des körpergewichtes |
EP0999830A1 (en) * | 1997-07-01 | 2000-05-17 | Pfizer Inc. | Sertraline salts and sustained-release dosage forms of sertraline |
ES2235337T3 (es) | 1997-07-09 | 2005-07-01 | Swiss Caps Rechte Und Lizenzen Ag | Procedimiento y dispositivo para fabricar una forma farmaceutica multicapa, fisiologicamente tolerable. |
US6103260A (en) * | 1997-07-17 | 2000-08-15 | Mcneil-Ppc, Inc. | Simethicone/anhydrous calcium phosphate compositions |
US6110499A (en) * | 1997-07-24 | 2000-08-29 | Alza Corporation | Phenytoin therapy |
US5942034A (en) | 1997-07-24 | 1999-08-24 | Bayer Corporation | Apparatus for the gelatin coating of medicaments |
DE19733505A1 (de) * | 1997-08-01 | 1999-02-04 | Knoll Ag | Schnell wirksames Analgeticum |
US6174548B1 (en) | 1998-08-28 | 2001-01-16 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
US6602522B1 (en) | 1997-11-14 | 2003-08-05 | Andrx Pharmaceuticals L.L.C. | Pharmaceutical formulation for acid-labile compounds |
US6096340A (en) * | 1997-11-14 | 2000-08-01 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
WO1999029297A1 (en) * | 1997-12-05 | 1999-06-17 | Alza Corporation | Osmotic dosage form comprising first and second coats |
US6485748B1 (en) * | 1997-12-12 | 2002-11-26 | Andrx Pharmaceuticals, Inc. | Once daily pharmaceutical tablet having a unitary core |
US6022554A (en) | 1997-12-15 | 2000-02-08 | American Home Products Corporation | Polymeric microporous film coated subcutaneous implant |
HUP0100469A2 (hu) | 1997-12-19 | 2001-08-28 | Smithkline Beecham Corporation | Eljárás harapással diszpergálható tabletták előállítására |
US6432442B1 (en) * | 1998-02-23 | 2002-08-13 | Mcneil-Ppc, Inc. | Chewable product |
US6110500A (en) | 1998-03-25 | 2000-08-29 | Temple University | Coated tablet with long term parabolic and zero-order release kinetics |
US6365185B1 (en) * | 1998-03-26 | 2002-04-02 | University Of Cincinnati | Self-destructing, controlled release peroral drug delivery system |
US6372254B1 (en) * | 1998-04-02 | 2002-04-16 | Impax Pharmaceuticals Inc. | Press coated, pulsatile drug delivery system suitable for oral administration |
AU748653B2 (en) | 1998-05-01 | 2002-06-06 | John F. Cline | Method for injection molding manufacture of controlled release devices |
US6365183B1 (en) | 1998-05-07 | 2002-04-02 | Alza Corporation | Method of fabricating a banded prolonged release active agent dosage form |
AU748359B2 (en) | 1998-05-15 | 2002-06-06 | Chugai Seiyaku Kabushiki Kaisha | Controlled-release formulations |
UA69413C2 (uk) | 1998-05-22 | 2004-09-15 | Брістол-Майерс Сквібб Компані | Фармацевтична композиція, яка містить серцевину та ентеросолюбільну оболонку, фармацевтична композиція у вигляді сфероїдальних гранул, спосіб одержання сфероїдальних гранул та спосіб одержання фармацевтичної композиції |
PT1083879E (pt) | 1998-06-03 | 2005-01-31 | Alza Corp | Metodos e dispositivos para proporcionar uma terapia de drogas prolongada |
US6106267A (en) * | 1998-06-05 | 2000-08-22 | Aylward; John T. | Apparatus for forming a compression-molded product |
US6099865A (en) * | 1998-07-08 | 2000-08-08 | Fmc Corporation | Croscarmellose taste masking |
US6103257A (en) | 1998-07-17 | 2000-08-15 | Num-Pop, Inc. | System for delivering pharmaceuticals to the buccal mucosa |
UA73092C2 (uk) | 1998-07-17 | 2005-06-15 | Брістол-Майерс Сквібб Компані | Таблетка з ентеросолюбільним покриттям і спосіб її приготування |
FR2781152B1 (fr) * | 1998-07-20 | 2001-07-06 | Permatec Tech Ag | Utilisation d'un polymere de type acrylique en tant qu'agent de desagregation |
DE19834180A1 (de) | 1998-07-29 | 2000-02-03 | Benckiser Nv | Zusammensetzung zur Verwendung in einer Geschirrspülmaschine |
US6200590B1 (en) * | 1998-08-10 | 2001-03-13 | Naphcare, Inc. | Controlled, phased-release suppository and its method of production |
DE19840256A1 (de) * | 1998-09-03 | 2000-03-09 | Basf Ag | Verfahren zur Herstellung von beschichteten festen Dosierungsformen |
US5997905A (en) | 1998-09-04 | 1999-12-07 | Mcneil-Ppc | Preparation of pharmaceutically active particles |
US6174547B1 (en) * | 1999-07-14 | 2001-01-16 | Alza Corporation | Dosage form comprising liquid formulation |
US6602521B1 (en) * | 1998-09-29 | 2003-08-05 | Impax Pharmaceuticals, Inc. | Multiplex drug delivery system suitable for oral administration |
US20010055613A1 (en) * | 1998-10-21 | 2001-12-27 | Beth A. Burnside | Oral pulsed dose drug delivery system |
JP3449253B2 (ja) * | 1998-10-29 | 2003-09-22 | シオノギクオリカプス株式会社 | 硬質カプセルの製造方法 |
US6165512A (en) | 1998-10-30 | 2000-12-26 | Fuisz Technologies Ltd. | Dosage forms containing taste masked active agents |
SE9803772D0 (sv) | 1998-11-05 | 1998-11-05 | Astra Ab | Pharmaceutical formulation |
US6270805B1 (en) * | 1998-11-06 | 2001-08-07 | Andrx Pharmaceuticals, Inc. | Two pellet controlled release formulation for water soluble drugs which contains an alkaline metal stearate |
US6183681B1 (en) * | 1998-12-07 | 2001-02-06 | Centurion International, Inc. | Multi-stage insert molding method |
DE59901613D1 (de) | 1999-02-10 | 2002-07-11 | Suwelack Skin & Health Care Ag | Beta-1,3-Glucan aus Euglena enthaltendes gefriergetrocknetes Erzeugnis, seine Herstellung und Verwendung |
US6274162B1 (en) | 2000-01-14 | 2001-08-14 | Bpsi Holdings, Inc. | Elegant film coating system |
US6248361B1 (en) | 1999-02-26 | 2001-06-19 | Integ, Ltd. | Water-soluble folic acid compositions |
DE19913692A1 (de) * | 1999-03-25 | 2000-09-28 | Basf Ag | Mechanisch stabile pharmazeutische Darreichungsformen, enthaltend flüssige oder halbfeste oberflächenaktive Substanzen |
US6090401A (en) | 1999-03-31 | 2000-07-18 | Mcneil-Ppc, Inc. | Stable foam composition |
JP3716901B2 (ja) * | 1999-04-14 | 2005-11-16 | シオノギクオリカプス株式会社 | セルロースエーテルフィルム |
US6248760B1 (en) * | 1999-04-14 | 2001-06-19 | Paul C Wilhelmsen | Tablet giving rapid release of nicotine for transmucosal administration |
DE19925710C2 (de) | 1999-06-07 | 2002-10-10 | Byk Gulden Lomberg Chem Fab | Neue Zubereitung und Darreichungsform enthaltend einen säurelabilen Protonenpumpenhemmer |
US6375963B1 (en) | 1999-06-16 | 2002-04-23 | Michael A. Repka | Bioadhesive hot-melt extruded film for topical and mucosal adhesion applications and drug delivery and process for preparation thereof |
US6555139B2 (en) * | 1999-06-28 | 2003-04-29 | Wockhardt Europe Limited | Preparation of micron-size pharmaceutical particles by microfluidization |
US20020102309A1 (en) * | 1999-09-14 | 2002-08-01 | Jane C. I. Hirsh | Controlled release formulation for administration of an anti-inflammatory naphthalene derivative |
DE19954420A1 (de) | 1999-11-12 | 2001-05-31 | Lohmann Therapie Syst Lts | Zubereitung, bestehend aus einer film-, folien- oder oblatenförmigen Darreichungsform mit zweischichtigem Aufbau und integrierter Kennzeichnung |
DE19960494A1 (de) * | 1999-12-15 | 2001-06-21 | Knoll Ag | Vorrichtung und Verfahren zum Herstellen von festen wirkstoffhaltigen Formen |
WO2001047498A2 (en) * | 1999-12-23 | 2001-07-05 | Pfizer Products Inc. | Hydrogel-driven layered drug dosage form comprising sertraline |
DE19963569B4 (de) | 1999-12-29 | 2006-11-16 | Reckitt Benckiser N.V. | Zusammensetzung zur Verwendung in einer Geschirrspülmaschine |
US6599532B2 (en) | 2000-01-13 | 2003-07-29 | Osmotica Corp. | Osmotic device containing alprazolam and an antipsychotic agent |
US6627223B2 (en) | 2000-02-11 | 2003-09-30 | Eurand Pharmaceuticals Ltd. | Timed pulsatile drug delivery systems |
FR2807034B1 (fr) | 2000-03-29 | 2002-06-14 | Roquette Freres | Mannitol pulverulent et son procede de fabrication |
US20020028240A1 (en) * | 2000-04-17 | 2002-03-07 | Toyohiro Sawada | Timed-release compression-coated solid composition for oral administration |
US6372252B1 (en) | 2000-04-28 | 2002-04-16 | Adams Laboratories, Inc. | Guaifenesin sustained release formulation and tablets |
GB2362350A (en) | 2000-05-11 | 2001-11-21 | Reckitt Benekiser N V | Process and press for the production of tablets |
US20030086972A1 (en) | 2000-08-09 | 2003-05-08 | Appel Leah E. | Hydrogel-driven drug dosage form |
US6727200B2 (en) * | 2000-08-31 | 2004-04-27 | Mra Laboratories, Inc. | High dielectric constant very low fired X7R ceramic capacitor, and powder for making |
AU2001288938A1 (en) | 2000-09-07 | 2002-03-22 | Akpharma Inc. | Edible candy compositions and methods of using the same |
GB0027471D0 (en) * | 2000-11-08 | 2000-12-27 | Smithkline Beecham Plc | Processes |
WO2002066015A1 (en) | 2001-02-16 | 2002-08-29 | Bristol-Myers Squibb Pharma Company | Use of polyalkylamine polymers in controlled release devices |
US20030070584A1 (en) * | 2001-05-15 | 2003-04-17 | Cynthia Gulian | Dip coating compositions containing cellulose ethers |
CA2453290A1 (en) | 2001-07-16 | 2003-01-30 | Astrazeneca Ab | Pharmaceutical formulation comprising a proton pump inhibitor and antacids |
US6558722B2 (en) * | 2001-07-18 | 2003-05-06 | Wm. Wrigley Jr. Company | Use of powdered gum in making a coating for a confection |
GB0120835D0 (en) | 2001-08-28 | 2001-10-17 | Smithkline Beecham Plc | Process |
US20030059466A1 (en) | 2001-09-14 | 2003-03-27 | Pawan Seth | Delayed release tablet of venlafaxin |
US7122143B2 (en) * | 2001-09-28 | 2006-10-17 | Mcneil-Ppc, Inc. | Methods for manufacturing dosage forms |
US20030066068A1 (en) | 2001-09-28 | 2003-04-03 | Koninklijke Philips Electronics N.V. | Individual recommender database using profiles of others |
US6767200B2 (en) * | 2001-09-28 | 2004-07-27 | Mcneil-Ppc, Inc. | Systems, methods and apparatuses for manufacturing dosage forms |
US7323192B2 (en) | 2001-09-28 | 2008-01-29 | Mcneil-Ppc, Inc. | Immediate release tablet |
US6837696B2 (en) * | 2001-09-28 | 2005-01-04 | Mcneil-Ppc, Inc. | Apparatus for manufacturing dosage forms |
US6982094B2 (en) * | 2001-09-28 | 2006-01-03 | Mcneil-Ppc, Inc. | Systems, methods and apparatuses for manufacturing dosage forms |
BR0206062A (pt) | 2001-09-28 | 2004-01-13 | Mcneil Ppc Inc | Formas de dosagem tendo um núcleo interno e invólucro externo |
US6742646B2 (en) * | 2001-09-28 | 2004-06-01 | Mcneil-Ppc, Inc. | Systems, methods and apparatuses for manufacturing dosage forms |
JP2005521662A (ja) | 2002-01-25 | 2005-07-21 | サンタラス インコーポレイティッド | プロトンポンプ阻害剤の経粘膜送達 |
AU2003220551A1 (en) | 2002-03-26 | 2003-10-13 | Euro-Celtique S.A. | Sustained-release gel coated compositions |
EP1764655A3 (en) | 2002-06-11 | 2007-09-19 | ASML Netherlands B.V. | Lithographic apparatus and device manufacturing method |
TW578439B (en) * | 2002-10-25 | 2004-03-01 | Ritdisplay Corp | Organic light emitting diode and material applied in the organic light emitting diode |
WO2004112838A2 (en) * | 2003-05-21 | 2004-12-29 | Control Delivery Systems, Inc. | Codrugs of diclofenac |
US20050074514A1 (en) | 2003-10-02 | 2005-04-07 | Anderson Oliver B. | Zero cycle molding systems, methods and apparatuses for manufacturing dosage forms |
EP1802285B1 (en) | 2004-10-21 | 2013-02-27 | Aptalis Pharmatech, Inc. | Taste-masked pharmaceutical compositions with gastrosoluble pore-formers |
-
2002
- 2002-09-28 BR BR0206062-0A patent/BR0206062A/pt not_active IP Right Cessation
- 2002-09-28 DE DE60239945T patent/DE60239945D1/de not_active Expired - Lifetime
- 2002-09-28 WO PCT/US2002/031164 patent/WO2003026616A1/en active Application Filing
- 2002-09-28 EP EP02766427A patent/EP1429742B1/en not_active Expired - Lifetime
- 2002-09-28 NZ NZ532097A patent/NZ532097A/en unknown
- 2002-09-28 JP JP2003530249A patent/JP2005508325A/ja active Pending
- 2002-09-28 CN CNA028235401A patent/CN1596102A/zh active Pending
- 2002-09-28 MX MXPA04002978A patent/MXPA04002978A/es unknown
- 2002-09-28 EP EP02766426.7A patent/EP1429724B1/en not_active Expired - Lifetime
- 2002-09-28 CA CA002461684A patent/CA2461684A1/en not_active Abandoned
- 2002-09-28 ES ES02799684T patent/ES2311073T3/es not_active Expired - Lifetime
- 2002-09-28 CN CNB028233727A patent/CN100364515C/zh not_active Expired - Fee Related
- 2002-09-28 EP EP02773676A patent/EP1429743A1/en not_active Withdrawn
- 2002-09-28 CN CNA028236386A patent/CN1596100A/zh active Pending
- 2002-09-28 US US10/476,530 patent/US8545887B2/en not_active Expired - Fee Related
- 2002-09-28 ES ES02766426.7T patent/ES2444549T3/es not_active Expired - Lifetime
- 2002-09-28 WO PCT/US2002/031024 patent/WO2003026625A1/en active IP Right Grant
- 2002-09-28 JP JP2003530253A patent/JP2005509605A/ja active Pending
- 2002-09-28 KR KR10-2004-7004663A patent/KR20040045034A/ko not_active Application Discontinuation
- 2002-09-28 CN CNA028233476A patent/CN1592610A/zh active Pending
- 2002-09-28 EP EP02799684A patent/EP1429746B1/en not_active Expired - Lifetime
- 2002-09-28 DE DE60237294T patent/DE60237294D1/de not_active Expired - Lifetime
- 2002-09-28 BR BR0212950-7A patent/BR0212950A/pt not_active Application Discontinuation
- 2002-09-28 WO PCT/US2002/031163 patent/WO2003026627A1/en active Application Filing
- 2002-09-28 CA CA002461865A patent/CA2461865A1/en not_active Abandoned
- 2002-09-28 BR BR0213591-4A patent/BR0213591A/pt not_active IP Right Cessation
- 2002-09-28 PL PL02369134A patent/PL369134A1/xx not_active Application Discontinuation
- 2002-09-28 MX MXPA04002973A patent/MXPA04002973A/es not_active Application Discontinuation
- 2002-09-28 WO PCT/US2002/031117 patent/WO2003026629A2/en active Application Filing
- 2002-09-28 WO PCT/US2002/031063 patent/WO2003026628A2/en active Application Filing
- 2002-09-28 CA CA002461653A patent/CA2461653A1/en not_active Abandoned
- 2002-09-28 US US10/476,529 patent/US20050019407A1/en not_active Abandoned
- 2002-09-28 CA CA2461659A patent/CA2461659C/en not_active Expired - Fee Related
- 2002-09-28 NZ NZ532568A patent/NZ532568A/en unknown
- 2002-09-28 AU AU2002330164A patent/AU2002330164A1/en not_active Abandoned
- 2002-09-28 KR KR10-2004-7004655A patent/KR20040037206A/ko not_active Application Discontinuation
- 2002-09-28 NZ NZ532096A patent/NZ532096A/en unknown
- 2002-09-28 BR BR0212946-9A patent/BR0212946A/pt not_active Application Discontinuation
- 2002-09-28 MX MXPA04002975A patent/MXPA04002975A/es unknown
- 2002-09-28 JP JP2003530267A patent/JP2005511515A/ja active Pending
- 2002-09-28 AT AT02799685T patent/ATE476957T1/de not_active IP Right Cessation
- 2002-09-28 JP JP2003530262A patent/JP2005508327A/ja active Pending
- 2002-09-28 JP JP2003530266A patent/JP2005535558A/ja active Pending
- 2002-09-28 US US10/476,514 patent/US20040170750A1/en not_active Abandoned
- 2002-09-28 CA CA002461616A patent/CA2461616A1/en not_active Abandoned
- 2002-09-28 MX MXPA04002979A patent/MXPA04002979A/es unknown
- 2002-09-28 EP EP02799682A patent/EP1438028A1/en not_active Withdrawn
- 2002-09-28 BR BR0213589-2A patent/BR0213589A/pt active Search and Examination
- 2002-09-28 MX MXPA04002992A patent/MXPA04002992A/es unknown
- 2002-09-28 MX MXPA04002980A patent/MXPA04002980A/es unknown
- 2002-09-28 EP EP02783988A patent/EP1429738B1/en not_active Expired - Lifetime
- 2002-09-28 US US10/476,238 patent/US20040241236A1/en not_active Abandoned
- 2002-09-28 KR KR10-2004-7004648A patent/KR20040045026A/ko not_active Application Discontinuation
- 2002-09-28 BR BR0206061-2A patent/BR0206061A/pt not_active Application Discontinuation
- 2002-09-28 HU HU0401686A patent/HUP0401686A3/hu unknown
- 2002-09-28 WO PCT/US2002/031066 patent/WO2003026612A2/en active Application Filing
- 2002-09-28 AT AT02766427T patent/ATE507823T1/de not_active IP Right Cessation
- 2002-09-28 JP JP2003530252A patent/JP2005508326A/ja active Pending
- 2002-09-28 BR BR0213588-4A patent/BR0213588A/pt not_active Application Discontinuation
- 2002-09-28 EP EP02782085A patent/EP1429745A2/en not_active Withdrawn
- 2002-09-28 WO PCT/US2002/031115 patent/WO2003026614A1/en active Application Filing
- 2002-09-28 CN CNA028233611A patent/CN1638740A/zh active Pending
- 2002-09-28 CA CA002447984A patent/CA2447984A1/en not_active Abandoned
- 2002-09-28 EP EP02799685A patent/EP1438018B1/en not_active Expired - Lifetime
- 2002-09-28 WO PCT/US2002/031062 patent/WO2003026626A2/en active IP Right Grant
- 2002-09-28 CA CA2461354A patent/CA2461354C/en not_active Expired - Fee Related
- 2002-09-28 KR KR10-2004-7004656A patent/KR20040045030A/ko not_active Application Discontinuation
- 2002-09-28 CA CA002446759A patent/CA2446759A1/en not_active Abandoned
- 2002-09-28 WO PCT/US2002/031067 patent/WO2003026613A1/en not_active Application Discontinuation
- 2002-09-28 EP EP02799691A patent/EP1432404A1/en not_active Withdrawn
- 2002-09-28 KR KR10-2004-7004659A patent/KR20040045032A/ko not_active Application Discontinuation
- 2002-09-28 JP JP2003530261A patent/JP2005529059A/ja active Pending
- 2002-09-28 US US10/477,334 patent/US7968120B2/en not_active Expired - Fee Related
- 2002-09-28 KR KR10-2004-7004552A patent/KR20040066094A/ko not_active Application Discontinuation
- 2002-09-28 EP EP20020799690 patent/EP1463489A1/en not_active Withdrawn
- 2002-09-28 CA CA002461656A patent/CA2461656A1/en not_active Abandoned
- 2002-09-28 BR BR0213593-0A patent/BR0213593A/pt not_active Application Discontinuation
- 2002-09-28 WO PCT/US2002/031022 patent/WO2003026624A1/en not_active Application Discontinuation
- 2002-09-28 JP JP2003530265A patent/JP2005508330A/ja active Pending
- 2002-09-28 KR KR10-2004-7004642A patent/KR20040037203A/ko not_active Application Discontinuation
- 2002-09-28 MX MXPA04002974A patent/MXPA04002974A/es active IP Right Grant
- 2002-09-28 JP JP2003530263A patent/JP2005508328A/ja active Pending
- 2002-09-28 MX MXPA04002891A patent/MXPA04002891A/es active IP Right Grant
- 2002-09-28 CN CNA028233441A patent/CN1592611A/zh active Pending
- 2002-09-28 KR KR10-2004-7004662A patent/KR20040045033A/ko not_active Application Discontinuation
- 2002-09-28 JP JP2003530251A patent/JP2005509604A/ja active Pending
- 2002-09-28 MX MXPA04002884A patent/MXPA04002884A/es not_active Application Discontinuation
- 2002-09-28 US US10/476,504 patent/US20040213848A1/en not_active Abandoned
- 2002-09-28 US US10/432,488 patent/US20040062804A1/en not_active Abandoned
- 2002-09-28 MX MXPA04002981A patent/MXPA04002981A/es unknown
- 2002-09-28 WO PCT/US2002/031116 patent/WO2003026615A2/en active Application Filing
- 2002-09-28 BR BR0212951-5A patent/BR0212951A/pt not_active Application Discontinuation
- 2002-09-28 DE DE60223269T patent/DE60223269T2/de not_active Expired - Lifetime
- 2002-09-28 ES ES02783988T patent/ES2295427T3/es not_active Expired - Lifetime
- 2002-09-28 CA CA002446760A patent/CA2446760A1/en not_active Abandoned
- 2002-09-28 CN CNA028236505A patent/CN1596101A/zh active Pending
- 2002-09-28 BR BR0212921-3A patent/BR0212921A/pt not_active Application Discontinuation
- 2002-09-28 AT AT02799684T patent/ATE404179T1/de not_active IP Right Cessation
- 2002-09-28 CA CA002461870A patent/CA2461870A1/en not_active Abandoned
- 2002-09-28 KR KR10-2004-7004658A patent/KR20040045031A/ko not_active Application Discontinuation
- 2002-09-28 KR KR10-2004-7004657A patent/KR20040037207A/ko not_active Application Discontinuation
- 2002-09-28 WO PCT/US2002/031129 patent/WO2003026630A1/en not_active Application Discontinuation
- 2002-09-28 CA CA002461682A patent/CA2461682A1/en not_active Abandoned
- 2002-09-28 KR KR10-2004-7004664A patent/KR20040037208A/ko not_active Application Discontinuation
- 2002-09-28 CN CNA028233549A patent/CN1592612A/zh active Pending
- 2002-09-28 AT AT02783988T patent/ATE376826T1/de not_active IP Right Cessation
- 2002-09-28 CN CNA028236416A patent/CN1596104A/zh active Pending
- 2002-09-28 BR BR0206086-8A patent/BR0206086A/pt not_active Application Discontinuation
- 2002-09-28 MX MXPA04002976A patent/MXPA04002976A/es not_active Application Discontinuation
- 2002-09-28 EP EP02799689A patent/EP1438030A2/en not_active Withdrawn
- 2002-09-28 CN CNB028234308A patent/CN100408029C/zh not_active Expired - Fee Related
- 2002-09-28 PT PT02783988T patent/PT1429738E/pt unknown
- 2002-09-28 MX MXPA04002977A patent/MXPA04002977A/es unknown
- 2002-09-28 JP JP2003530264A patent/JP2005508329A/ja active Pending
- 2002-09-28 EP EP02773665A patent/EP1429737A1/en not_active Withdrawn
- 2002-09-28 US US10/484,485 patent/US20040241208A1/en not_active Abandoned
- 2002-09-28 DE DE60228281T patent/DE60228281D1/de not_active Expired - Lifetime
-
2003
- 2003-03-21 US US10/393,638 patent/US20030232082A1/en not_active Abandoned
- 2003-03-21 US US10/393,752 patent/US7635490B2/en not_active Expired - Fee Related
- 2003-03-21 US US10/393,765 patent/US20040018327A1/en not_active Abandoned
- 2003-03-21 US US10/393,871 patent/US7416738B2/en not_active Expired - Fee Related
- 2003-03-21 US US10/393,610 patent/US20030219484A1/en not_active Abandoned
- 2003-05-26 NO NO20032364A patent/NO20032364L/no not_active Application Discontinuation
- 2003-05-26 NO NO20032362A patent/NO20032362L/no not_active Application Discontinuation
- 2003-05-26 NO NO20032363A patent/NO20032363L/no not_active Application Discontinuation
-
2004
- 2004-04-20 NO NO20041613A patent/NO20041613L/no not_active Application Discontinuation
- 2004-04-28 CO CO04038884A patent/CO5570655A2/es unknown
-
2005
- 2005-07-04 HK HK05105590A patent/HK1072902A1/xx not_active IP Right Cessation
-
2008
- 2008-03-17 US US12/049,628 patent/US20080305150A1/en not_active Abandoned
-
2009
- 2009-02-24 US US12/391,475 patent/US7972624B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN1596100A (zh) | 可食用组合物及含可食用外壳的制剂 | |
EP3292866B1 (en) | Acetaminophen / ibuprofen combinations | |
CN101842085B (zh) | 口腔崩解剂型 | |
CN101299996A (zh) | 含有唾液诱生剂的口服组合物 | |
US20160346215A1 (en) | Pharmaceutical tablet containing a liquid filled capsule | |
WO2008157103A2 (en) | Modified release solid or semi-solid dosage forms | |
EP3091966B1 (en) | Process for making tablet using radiofrequency and lossy coated particles | |
JP2009530420A (ja) | 無作為な被覆を有する剤形 | |
KR20190126413A (ko) | 고주파 및 손실 코팅된 입자를 사용하여 정제를 제조하는 방법 | |
JP2006517182A (ja) | 2つのコア及び開口部を備えた加減放出型投薬形態 | |
JPH10130140A (ja) | グミ製剤の製造方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
AD01 | Patent right deemed abandoned | ||
C20 | Patent right or utility model deemed to be abandoned or is abandoned |