HUP0100469A2 - Eljárás harapással diszpergálható tabletták előállítására - Google Patents

Eljárás harapással diszpergálható tabletták előállítására

Info

Publication number
HUP0100469A2
HUP0100469A2 HU0100469A HUP0100469A HUP0100469A2 HU P0100469 A2 HUP0100469 A2 HU P0100469A2 HU 0100469 A HU0100469 A HU 0100469A HU P0100469 A HUP0100469 A HU P0100469A HU P0100469 A2 HUP0100469 A2 HU P0100469A2
Authority
HU
Hungary
Prior art keywords
maltodextrin
disintegrant
xylitol
sorbitol
pharmaceutically acceptable
Prior art date
Application number
HU0100469A
Other languages
English (en)
Inventor
Nageswara R. Palepu
Gopadi M. Venkatesh
Original Assignee
Smithkline Beecham Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corporation filed Critical Smithkline Beecham Corporation
Publication of HUP0100469A2 publication Critical patent/HUP0100469A2/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A találmány gyógyszerészeti hatóanyagokat tartalmazó, gyorsandiszpergálódó tabletta készítményre vonatkozik, amelytablettakészítmény tömörített granulátumokból álló szerkezettelrendelkezik; a granulátumok egy gyógyszerhatóanyagot a következőanyagok kombinációjával együtt tartalmazzák: egy viaszos anyag és egyerős édesítőszer és/vagy egy ízálcázó szer, egy, a xilit, mannit,maltodextrin vagy szorbit közül kiválasztott, illetve ezekkombinációjából álló gyógyászatilag elfogadható vivőanyag, és adottesetben egy ízesítőszer és egy dezintegráns; a granulátumok akövetkező extragranuláris komponensekkel együtt egy tablettaformávávannak összetömörítve: egy dezintegráns, egy édesítőszer és/vagyízálcázó szer, és egy, a xilit, mannit, maltodextrin vagy szorbitközül kiválasztott, illetve ezek kombinációjából álló gyógyászatilagelfogadható vivőanyag. A találmány kiterjed a fenti tablettakészítményelőállítási eljárására is, amelynek során A ízálcázott granulákotállítanak elő oly módon, hogy (i) összekevernek legalább egygyógyszerészeti hatóanyagot egy vagy több, a következők közülkiválasztott gyó- gyászatilag elfogadható vivőanyaggal: xilit,közvetlenül préselhető mannit, maltodextrin vagy szorbit; egy viaszosanyag; egy erős édesítőszer vagy ízálcázó szer; és adott esetben egydezintegráns és egy ízesítőszer; és (ii) az (i) lépés szerintikeveréket száraz granulálással (például hagyományos szárazgranulálással vagy hengerléses tömörítéssel), őrléssel és szitálássalelőkészítik a préseléshez; és B gyorsan diszpergálódó tablettákatállítanak elő oly módon, hogy (iii) a (ii) lépés szerinti terméketösszekeverik további, a következőkből álló gyógyászatilag elfogadhatóvivőanyagokkal: xilit, mannit, maltodextrin vagy szorbit; és adottesetben ízesítő szerrel, édesítőszerrel/ízálcázó szerrel ésdezintegránssal; és (iv) a (iii) lépés szerinti keveréket tablettákkápréselik. Ó
HU0100469A 1997-12-19 1998-12-17 Eljárás harapással diszpergálható tabletták előállítására HUP0100469A2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6825897P 1997-12-19 1997-12-19
PCT/US1998/027061 WO1999032092A1 (en) 1997-12-19 1998-12-17 Process for manufacturing bite-dispersion tablets

Publications (1)

Publication Number Publication Date
HUP0100469A2 true HUP0100469A2 (hu) 2001-08-28

Family

ID=22081416

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0100469A HUP0100469A2 (hu) 1997-12-19 1998-12-17 Eljárás harapással diszpergálható tabletták előállítására

Country Status (20)

Country Link
US (1) US6475510B1 (hu)
EP (1) EP1047407A4 (hu)
JP (1) JP2001526212A (hu)
KR (1) KR100775154B1 (hu)
CN (1) CN100379407C (hu)
AR (1) AR014133A1 (hu)
AU (2) AU1931999A (hu)
BR (1) BR9813808A (hu)
CA (1) CA2315088A1 (hu)
CO (1) CO4990940A1 (hu)
HU (1) HUP0100469A2 (hu)
IL (2) IL136831A0 (hu)
NO (1) NO20003150L (hu)
NZ (1) NZ505123A (hu)
PL (1) PL197989B1 (hu)
SA (1) SA99191111B1 (hu)
TR (1) TR200001856T2 (hu)
TW (1) TW586943B (hu)
WO (1) WO1999032092A1 (hu)
ZA (1) ZA9811630B (hu)

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Also Published As

Publication number Publication date
TR200001856T2 (tr) 2000-11-21
SA99191111B1 (ar) 2006-10-11
KR20010033328A (ko) 2001-04-25
AU2002300238B2 (en) 2003-01-02
CN1284867A (zh) 2001-02-21
US6475510B1 (en) 2002-11-05
SA99191111A (ar) 2005-12-03
PL341353A1 (en) 2001-04-09
NZ505123A (en) 2003-07-25
KR100775154B1 (ko) 2007-11-12
EP1047407A4 (en) 2007-05-02
NO20003150L (no) 2000-08-11
CO4990940A1 (es) 2000-12-26
BR9813808A (pt) 2002-05-28
PL197989B1 (pl) 2008-05-30
AU1931999A (en) 1999-07-12
AU2002300238C1 (en) 2004-03-04
EP1047407A1 (en) 2000-11-02
AR014133A1 (es) 2001-02-07
CN100379407C (zh) 2008-04-09
TW586943B (en) 2004-05-11
WO1999032092A1 (en) 1999-07-01
JP2001526212A (ja) 2001-12-18
CA2315088A1 (en) 1999-07-01
IL136831A (en) 2006-12-10
NO20003150D0 (no) 2000-06-16
IL136831A0 (en) 2001-06-14
ZA9811630B (en) 1999-06-21

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