GB2284760B - A method of preparing pharmaceutical compositions by melt pelletisation - Google Patents

A method of preparing pharmaceutical compositions by melt pelletisation

Info

Publication number
GB2284760B
GB2284760B GB9324045A GB9324045A GB2284760B GB 2284760 B GB2284760 B GB 2284760B GB 9324045 A GB9324045 A GB 9324045A GB 9324045 A GB9324045 A GB 9324045A GB 2284760 B GB2284760 B GB 2284760B
Authority
GB
United Kingdom
Prior art keywords
method
pharmaceutical compositions
preparing pharmaceutical
pelletisation
melt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
GB9324045A
Other versions
GB2284760A (en
GB9324045D0 (en
Inventor
Deborah Challis
Joanne Heafield
Trevor John Knott
Stewart Thomas Leslie
Sandra Therese Antoi Malkowska
Ronald Brown Miller
Derek Allan Prater
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Euroceltique SA
Original Assignee
Euroceltique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GB9324045A priority Critical patent/GB2284760B/en
Application filed by Euroceltique SA filed Critical Euroceltique SA
Publication of GB9324045D0 publication Critical patent/GB9324045D0/en
Priority claimed from IL11966094A external-priority patent/IL119660A/en
Priority claimed from DE9422335U external-priority patent/DE9422335U1/en
Priority claimed from EG26394A external-priority patent/EG20577A/en
Priority claimed from IL10994494A external-priority patent/IL109944A/en
Priority claimed from NZ260883A external-priority patent/NZ260883A/en
Priority claimed from BG99078A external-priority patent/BG62473B1/en
Priority claimed from BG99077A external-priority patent/BG62316B1/en
Priority claimed from EG61694A external-priority patent/EG20600A/en
Priority claimed from DE1994629710 external-priority patent/DE69429710D1/en
Priority claimed from EG74294A external-priority patent/EG20910A/en
Priority claimed from PL94305939A external-priority patent/PL178883B1/en
Publication of GB2284760A publication Critical patent/GB2284760A/en
Priority claimed from US08/607,852 external-priority patent/US5849240A/en
Priority claimed from US08/607,851 external-priority patent/US5891471A/en
Priority claimed from IN747MA1996 external-priority patent/IN182557B/en
Priority claimed from US08/843,571 external-priority patent/US5879705A/en
Publication of GB2284760B publication Critical patent/GB2284760B/en
Application granted granted Critical
Anticipated expiration legal-status Critical
Application status is Expired - Lifetime legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/485Morphinan derivatives, e.g. morphine, codeine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1617Organic compounds, e.g. phospholipids, fats
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2095Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/2833Organic macromolecular compounds
    • A61K9/286Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
GB9324045A 1993-11-23 1993-11-23 A method of preparing pharmaceutical compositions by melt pelletisation Expired - Lifetime GB2284760B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB9324045A GB2284760B (en) 1993-11-23 1993-11-23 A method of preparing pharmaceutical compositions by melt pelletisation

Applications Claiming Priority (123)

Application Number Priority Date Filing Date Title
GB9324045A GB2284760B (en) 1993-11-23 1993-11-23 A method of preparing pharmaceutical compositions by melt pelletisation
IL11966094A IL119660A (en) 1993-05-10 1994-04-27 Controlled release formulation comprising tramadol
NZ26040894A NZ260408A (en) 1993-05-10 1994-04-27 Controlled release preparation comprising tramadol
IL10946094A IL109460A (en) 1993-05-10 1994-04-27 Controlled release formulation comprising tramadol
SG1996008705A SG67347A1 (en) 1993-05-10 1994-04-29 Controlled release formulation
EP04014719A EP1468679B1 (en) 1993-05-10 1994-04-29 Controlled release formulation containing tramadol
PT04014719T PT1468679E (en) 1993-05-10 1994-04-29 Controlled frequency formula containing tramadol
DE1994634479 DE69434479D1 (en) 1993-05-10 1994-04-29 Tramadolhaltiges drug with controlled drug delivery
AT95114527T AT201989T (en) 1993-05-10 1994-04-29 Drug controlled release
EP95114527A EP0699436B2 (en) 1993-05-10 1994-04-29 Controlled release formulation
EP96101147A EP0729751A1 (en) 1993-05-10 1994-04-29 Controlled release formulation containing tramadol
PT04030658T PT1527775E (en) 1993-05-10 1994-04-29 Controlled release formulation containing tramadol
DK04030658.1T DK1527775T3 (en) 1993-05-10 1994-04-29 Tramadolholdig controlled release composition
DK95114527.5T DK0699436T4 (en) 1993-05-10 1994-04-29 Controlled release preparation
DE2009004973 DE09004973T8 (en) 1993-05-10 1994-04-29 The controlled release formulation
DE1994600215 DE69400215D1 (en) 1993-05-10 1994-04-29 Tramadol-containing pharmaceutical sustained release
DE1994635295 DE69435295D1 (en) 1993-05-10 1994-04-29 Tramadolhaltiges drug with controlled drug delivery
EP04030658A EP1527775B1 (en) 1993-05-10 1994-04-29 Controlled release formulation containing tramadol
DE1996101147 DE729751T1 (en) 1993-05-10 1994-04-29 Tramadolhaltiges drug sustained release
DE1994627472 DE69427472D1 (en) 1993-05-10 1994-04-29 Drug controlled release
AT04014719T AT303140T (en) 1993-05-10 1994-04-29 Tramadolhaltiges drug-controlled drug duty
DE69427472T DE69427472T3 (en) 1993-05-10 1994-04-29 Drugs with controlled release of active ingredient
ES04014719T ES2247574T3 (en) 1993-05-10 1994-04-29 Controlled release formulation comprising tramadol.
ES94303128T ES2088312T3 (en) 1993-05-10 1994-04-29 Controlled release formulation containing tramadol.
DE9422335U DE9422335U1 (en) 1993-05-10 1994-04-29 Controlled Release Formulation
ES95114527T ES2159591T5 (en) 1993-05-10 1994-04-29 Controlled Release Formulation
AT04030658T AT468850T (en) 1993-05-10 1994-04-29 Tramadolhaltiges drug-controlled drug duty
DE1994634479 DE69434479T2 (en) 1993-05-10 1994-04-29 Tramadolhaltiges drug with controlled drug delivery
DK04014719T DK1468679T3 (en) 1993-05-10 1994-04-29 Tramadolholdig controlled release formulation
EP19940303128 EP0624366B1 (en) 1993-05-10 1994-04-29 Controlled release formulation containing tramadol
EP09004973.5A EP2103303B1 (en) 1993-05-10 1994-04-29 Controlled release formulation containing tramadol
DE1995114527 DE699436T1 (en) 1993-05-10 1994-04-29 Drug controlled release
DK94303128T DK0624366T3 (en) 1993-05-10 1994-04-29 Composition containing tramadol controlled release
DE1994600215 DE69400215T2 (en) 1993-05-10 1994-04-29 Tramadol-containing pharmaceutical sustained release
PT95114527T PT699436E (en) 1993-05-10 1994-04-29 Controlled liberation formula
ES04030658T ES2346651T3 (en) 1993-05-10 1994-04-29 Controlled release formulation that tramadol sustained release formulation containing tramadol.
AT94303128T AT138566T (en) 1993-05-10 1994-04-29 Tramadol drug-containing sustained-release
ES09004973T ES2331046T1 (en) 1993-05-10 1994-04-29 Controlled release formulation.
CZ19941093A CZ288517B6 (en) 1993-05-10 1994-05-04 Pharmaceutical preparation in unit dosage form and process of its preparation
HU9401478A HU228177B1 (en) 1993-05-10 1994-05-06 Controlled release formulation containing tramadol
FI942092A FI942092A (en) 1993-05-10 1994-05-06 The controlled-release preparation
EG26394A EG20577A (en) 1993-05-10 1994-05-08 Controlled release formulation contaning tramadol
NO941719A NO306446B1 (en) 1993-05-10 1994-05-09 Oral pharmaceutical composition comprising a tramadol controlled frigjöringsvirkning
CA 2123160 CA2123160C (en) 1993-05-10 1994-05-09 Controlled release formulation
AU61963/94A AU6196394A (en) 1993-05-10 1994-05-09 Controlled release formulation
SK541-94A SK279971B6 (en) 1993-05-10 1994-05-10 Controlled release pharmaceutical composition and process for its preparation
SK1437-98A SK283143B6 (en) 1993-05-10 1994-05-10 Pharmaceutical preparation for controlled release
US08/241,129 US5591452A (en) 1993-05-10 1994-05-10 Controlled release formulation
JP6096671A JP3045924B2 (en) 1993-05-10 1994-05-10 Oral pharmaceutical formulations release was adjusted
IDP991104D ID25988A (en) 1993-05-10 1994-05-10 DRUG FORMULATIONS THAT CAN BE GOVERNED dissolution (Denomination of P-940 726)
CN 94105356 CN1094755C (en) 1993-05-10 1994-05-10 Controlled release agent containing reamine benzene ring alcohol or it salt
TW85103273A TW496736B (en) 1993-05-10 1994-05-12 Controlled release formulation
IL10994494A IL109944A (en) 1993-07-01 1994-06-08 Sustained release dosage unit forms containing morphine and a method of preparing these sustained release dosage unit forms
EP94304144A EP0636370B2 (en) 1993-07-01 1994-06-09 Sustained release compositions containing morphine
DE1994614046 DE69414046T3 (en) 1993-07-01 1994-06-09 Morphine-containing drug compositions sustained release
AT94304144T AT172376T (en) 1993-07-01 1994-06-09 Morphine-containing drug compositions sustained release
DE1994614046 DE69414046D1 (en) 1993-07-01 1994-06-09 Morphine-containing drug compositions sustained release
ES94304144T ES2124372T5 (en) 1993-07-01 1994-06-09 Sustained release compositions containing morphine.
DK94304144T DK0636370T4 (en) 1993-07-01 1994-06-09 Depot preparations containing morphine
SG1996009186A SG50706A1 (en) 1993-07-01 1994-06-09 Sustained release compositions and a method of preparing pharmaceutical compositions
SK763-94A SK280534B6 (en) 1993-07-01 1994-06-23 Sustained release preparations of morphine and a method of preparing the same
CZ19941550A CZ287918B6 (en) 1993-07-01 1994-06-23 Orally administered unit dosage form with controlled release and process for preparing thereof
NZ260883A NZ260883A (en) 1993-07-01 1994-06-29 Oral sustained-release medicaments containing morphine
PL30406294A PL179282B1 (en) 1993-07-01 1994-06-30 Retarded release compositions and method of obtaining such compositions
AU66105/94A AU6610594A (en) 1991-12-24 1994-06-30 Sustained release compositions and a method of preparing pharmaceutical compositions
CA 2127166 CA2127166C (en) 1993-07-01 1994-06-30 Sustained release morphine compositions and a method of preparation
NO942470A NO306449B1 (en) 1993-07-01 1994-06-30 Orally administrable morphine formulation for sustained release as well as preparation of multiparticulates for use in the composition
FI943141A FI114285B (en) 1993-07-01 1994-06-30 Process for the preparation of slow release pharmaceutical dosage unit form
HU9402007A HU220075B (en) 1993-07-01 1994-07-01 Sustained-release pharmaceutical formulation and a process for their preparation and
KR10-1994-0015740A KR100365572B1 (en) 1993-07-01 1994-07-01 Production method of sustained-release compositions and pharmaceutical compositions
JP15121994A JP3647897B2 (en) 1993-07-01 1994-07-01 Sustained-release unit dosage form
BG99077A BG62316B1 (en) 1993-10-07 1994-09-29 Pharmaceutical forms with continuous release and method for their preparation
BG99078A BG62473B1 (en) 1993-11-23 1994-09-29 Pharmaceutical preparation with monitored release
EG61694A EG20600A (en) 1993-10-07 1994-10-03 Sustained release compositions and a method of preparing pharmaceutical compositions
DE1994629710 DE69429710D1 (en) 1993-11-23 1994-11-17 A process for preparing a pharmaceutical composition having sustained-release
AT94308493T AT212224T (en) 1993-11-23 1994-11-17 A process for producing a pharmaceutical composition having sustained-release
PT94308493T PT654263E (en) 1993-11-23 1994-11-17 Method for the preparation of a prolonged libertyacao composition
ES94308493T ES2168290T3 (en) 1993-11-23 1994-11-17 Method for preparing a sustained release composition.
EP19940308493 EP0654263B1 (en) 1993-11-23 1994-11-17 Method for preparing a sustained release composition
DK94308493T DK0654263T3 (en) 1993-11-23 1994-11-17 A process for the preparation of a composition with sustained-release
DE1994629710 DE69429710T2 (en) 1993-11-23 1994-11-17 A process for preparing a pharmaceutical composition having sustained-release
NZ26495394A NZ264953A (en) 1993-11-23 1994-11-18 Manufacture of drug-containing particles from a mixture of particulate drug and a particulate hydrophobic and/or hydrophilic fusible carrier or diluent in a high speed mixer such that the carrier/diluent melts and breaking up the agglomerates thus formed; sustained release forms
IL11170994A IL111709A (en) 1993-11-23 1994-11-21 Process for the manufacture of sustained release particles and dosage forms comprising particles obtained by the process
IN1134MA1994 IN179010B (en) 1993-11-23 1994-11-21 A process for the manufacture of a pharmaceutical product
CZ19942866A CZ289650B6 (en) 1993-11-23 1994-11-21 Process for preparing a medicament controllably releasing active substance thereof
BG99198A BG62429B1 (en) 1993-11-23 1994-11-21 Method for the preparation of pharmaceutical compositions
NO19944473A NO314124B1 (en) 1993-11-23 1994-11-22 A process for preparing particles
PL94305939A PL178883B1 (en) 1993-11-23 1994-11-22 Prolonged release compositions and method of obtaining them
SK1406-94A SK280496B6 (en) 1993-11-23 1994-11-22 Process for preparing particles with permanent release of active substance
FI945476A FI113335B (en) 1993-11-23 1994-11-22 Process for the preparation of pharmaceutical compositions useful in the particles
EG74294A EG20910A (en) 1993-11-23 1994-11-22 Sustained release compositions and a method of preparing pharmaceutical compositions
HU9403353A HU217205B (en) 1993-11-23 1994-11-22 Delayed-release formulations and pharmaceutical products, a process for preparing
CN 94118503 CN1121213C (en) 1993-11-23 1994-11-23 Method of preparing sustained release compositions
AU79015/94A AU682223C (en) 1993-11-23 1994-11-23 Sustained release compositions and a method of preparing pharmaceutical compositions
ZA9409296A ZA9409296B (en) 1993-11-23 1994-11-23 Sustained release compositions and a method of preparing pharmaceutical compositions.
JP28993694A JP3411114B2 (en) 1993-11-23 1994-11-24 Method for producing a sustained release composition and pharmaceutical compositions
US08/449,772 US6326027B1 (en) 1993-05-10 1995-05-24 Controlled release formulation
US08/607,851 US5891471A (en) 1993-11-23 1996-02-27 Pharmaceutical multiparticulates
US08/607,852 US5849240A (en) 1993-11-23 1996-02-27 Method of preparing sustained release pharmaceutical compositions
IN747MA1996 IN182557B (en) 1993-11-23 1996-05-06 A method of producing a controlled release analgesic pharmaceutical composition
GR960401422T GR3020084T3 (en) 1993-05-10 1996-05-30 Controlled release formulation containing tramadol.
US08/677,798 US6254887B1 (en) 1993-05-10 1996-07-10 Controlled release tramadol
IL11966096A IL119660D0 (en) 1993-05-10 1996-11-20 Controlled release formulation
US08/843,571 US5879705A (en) 1993-07-27 1997-04-18 Sustained release compositions of morphine and a method of preparing pharmaceutical compositions
US08/944,106 US5965163A (en) 1993-11-23 1997-09-30 Substained release compositions and a method of preparing pharmaceutical compositions
AU39957/97A AU3995797A (en) 1993-05-10 1997-10-07 Controlled release formulation
AU52995/98A AU722358B2 (en) 1991-12-24 1998-02-06 Sustained release compositions and a method of preparing pharmaceutical compositions
JP22971898A JP3267561B2 (en) 1993-05-10 1998-08-14 Tramadol or use and analgesic agents of the pharmaceutically acceptable salt thereof
US09/264,399 US6143328A (en) 1993-07-27 1999-03-08 Sustained release compositions and a method of preparing pharmaceutical compositions
CNB991066421A CN1146410C (en) 1993-05-10 1999-05-17 Controlled release formulation
NO19993484A NO313124B1 (en) 1993-05-10 1999-07-15 Use of tramadol in the manufacture of a medicament for treating pain
US09/370,270 US6162467A (en) 1993-11-23 1999-08-09 Sustained release compositions and a method of preparing pharmaceutical compositions
AT81699U AT3413U3 (en) 1993-05-10 1999-11-25 Drug with controlled release of tramadol
US09/740,732 US20010019725A1 (en) 1993-11-23 2000-12-19 Sustained release compositions and a method of preparing pharmaceutical compositions
US09/800,204 US7074430B2 (en) 1993-05-10 2001-03-06 Controlled release tramadol tramadol formulation
NO20013566A NO331650B1 (en) 1993-05-10 2001-07-19 The oral composition of tramadol or a pharmaceutically acceptable salt thereof controlled frigjoringsvirkning
GR20010401419T GR3036565T3 (en) 1993-05-10 2001-09-06 Controlled release formulation
JP2001297270A JP3443574B2 (en) 1993-05-10 2001-09-27 Tramadol or analgesic agent containing the salt
JP2002271157A JP2003113075A (en) 1993-11-23 2002-09-18 Sustained release composition
FI20030560A FI121565B (en) 1993-05-10 2003-04-14 Process for the preparation of a controlled release preparation of tramadol
US11/435,015 US20060269603A1 (en) 1993-05-10 2006-05-16 Controlled release tramadol formulations
US12/152,474 US20090117191A1 (en) 1993-05-10 2008-05-14 Controlled release tramadol formulations
FI20105856A FI122717B (en) 1993-05-10 2010-08-17 The method produces a controlled release preparation of tramadol hydrochloride

Publications (3)

Publication Number Publication Date
GB9324045D0 GB9324045D0 (en) 1994-01-12
GB2284760A GB2284760A (en) 1995-06-21
GB2284760B true GB2284760B (en) 1998-06-24

Family

ID=10745553

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9324045A Expired - Lifetime GB2284760B (en) 1993-11-23 1993-11-23 A method of preparing pharmaceutical compositions by melt pelletisation

Country Status (3)

Country Link
GB (1) GB2284760B (en)
IN (1) IN179010B (en)
ZA (1) ZA9409296B (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843480A (en) 1994-03-14 1998-12-01 Euro-Celtique, S.A. Controlled release diamorphine formulation
US5849240A (en) 1993-11-23 1998-12-15 Euro-Celtique, S.A. Method of preparing sustained release pharmaceutical compositions
US5891471A (en) 1993-11-23 1999-04-06 Euro-Celtique, S.A. Pharmaceutical multiparticulates
US5958452A (en) 1994-11-04 1999-09-28 Euro-Celtique, S.A. Extruded orally administrable opioid formulations
US6068855A (en) 1994-11-03 2000-05-30 Euro-Celtique S. A. Pharmaceutical composition containing a fusible carrier and method for producing the same
US7829120B2 (en) 2005-09-09 2010-11-09 Labopharm Inc. Trazodone composition for once a day administration
US7988998B2 (en) 2002-10-25 2011-08-02 Labopharm Inc. Sustained-release tramadol formulations with 24-hour efficacy
US8487002B2 (en) 2002-10-25 2013-07-16 Paladin Labs Inc. Controlled-release compositions

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* Cited by examiner, † Cited by third party
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WO1998000143A1 (en) * 1996-06-28 1998-01-08 Knoll Pharmaceutical Company Slow release pharmaceutical compositions and methods of making same
DE19918325A1 (en) 1999-04-22 2000-10-26 Euro Celtique Sa Extruded drug dosage form, e.g. granulate for tableting, comprising an active agent in a polysaccharide-containing matrix, giving a release profile which is controllable by extrusion conditions and/or the inclusion of additives
US7838026B2 (en) 2001-09-28 2010-11-23 Mcneil-Ppc, Inc. Burst-release polymer composition and dosage forms comprising the same
US7122143B2 (en) 2001-09-28 2006-10-17 Mcneil-Ppc, Inc. Methods for manufacturing dosage forms
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JP2005508326A (en) * 2001-09-28 2005-03-31 マクニール−ピーピーシー・インコーポレイテッドMcneil−Ppc,Incorporated Reforming the dosage forms for release
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