GB2284760B - A method of preparing pharmaceutical compositions by melt pelletisation - Google Patents

A method of preparing pharmaceutical compositions by melt pelletisation

Info

Publication number
GB2284760B
GB2284760B GB9324045A GB9324045A GB2284760B GB 2284760 B GB2284760 B GB 2284760B GB 9324045 A GB9324045 A GB 9324045A GB 9324045 A GB9324045 A GB 9324045A GB 2284760 B GB2284760 B GB 2284760B
Authority
GB
Grant status
Grant
Patent type
Prior art keywords
method
preparing
pharmaceutical
compositions
melt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
GB9324045A
Other versions
GB9324045D0 (en )
GB2284760A (en )
Inventor
Deborah Challis
Joanne Heafield
Trevor John Knott
Stewart Thomas Leslie
Sandra Therese Antoi Malkowska
Ronald Brown Miller
Derek Allan Prater
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Euroceltique SA
Original Assignee
Euroceltique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Grant date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/485Morphinan derivatives, e.g. morphine, codeine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1617Organic compounds, e.g. phospholipids, fats
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2095Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/2833Organic macromolecular compounds
    • A61K9/286Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
GB9324045A 1993-11-23 1993-11-23 A method of preparing pharmaceutical compositions by melt pelletisation Expired - Lifetime GB2284760B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB9324045A GB2284760B (en) 1993-11-23 1993-11-23 A method of preparing pharmaceutical compositions by melt pelletisation

Applications Claiming Priority (67)

Application Number Priority Date Filing Date Title
GB9324045A GB2284760B (en) 1993-11-23 1993-11-23 A method of preparing pharmaceutical compositions by melt pelletisation
ES04030658T ES2346651T3 (en) 1993-05-10 1994-04-29 Controlled release formulation that tramadol sustained release formulation containing tramadol.
DE2009004973 DE09004973T8 (en) 1993-05-10 1994-04-29 The controlled release formulation
DE1996101147 DE729751T1 (en) 1993-05-10 1994-04-29 Tramadolhaltiges drug sustained release
EP19950114527 EP0699436B2 (en) 1993-05-10 1994-04-29 Controlled release formulation
DE19949422335 DE9422335U1 (en) 1993-05-10 1994-04-29 Controlled Release Formulation
EP20090004973 EP2103303B1 (en) 1993-05-10 1994-04-29 Controlled release formulation containing tramadol
DK95114527T DK0699436T4 (en) 1993-05-10 1994-04-29 Controlled release preparation
EP19960101147 EP0729751A1 (en) 1993-05-10 1994-04-29 Controlled release formulation containing tramadol
ES09004973T ES2331046T1 (en) 1993-05-10 1994-04-29 Controlled release formulation.
DE1994600215 DE69400215D1 (en) 1993-05-10 1994-04-29 Tramadol-containing pharmaceutical sustained release
DE1994634479 DE69434479T2 (en) 1993-05-10 1994-04-29 Tramadolhaltiges drug with controlled drug delivery
DK04014719T DK1468679T3 (en) 1993-05-10 1994-04-29 Tramadolholdig controlled release formulation
DE1994600215 DE69400215T2 (en) 1993-05-10 1994-04-29 Tramadol-containing pharmaceutical sustained release
ES04014719T ES2247574T3 (en) 1993-05-10 1994-04-29 Controlled release formulation comprising tramadol.
DE1994627472 DE69427472T3 (en) 1993-05-10 1994-04-29 Drug controlled release
DE1994635295 DE69435295D1 (en) 1993-05-10 1994-04-29 Tramadolhaltiges drug with controlled drug delivery
DE1994627472 DE69427472D1 (en) 1993-05-10 1994-04-29 Drug controlled release
DE1994634479 DE69434479D1 (en) 1993-05-10 1994-04-29 Tramadolhaltiges drug with controlled drug delivery
EP20040014719 EP1468679B1 (en) 1993-05-10 1994-04-29 Controlled release formulation containing tramadol
ES95114527T ES2159591T5 (en) 1993-05-10 1994-04-29 Controlled Release Formulation
DE1995114527 DE699436T1 (en) 1993-05-10 1994-04-29 Drug controlled release
DK94303128T DK0624366T3 (en) 1993-05-10 1994-04-29 Composition containing tramadol controlled release
ES94303128T ES2088312T3 (en) 1993-05-10 1994-04-29 Controlled release formulation containing tramadol.
EP19940303128 EP0624366B1 (en) 1993-05-10 1994-04-29 Controlled release formulation containing tramadol
DK04030658T DK1527775T3 (en) 1993-05-10 1994-04-29 Tramadolholdig controlled release composition
EP20040030658 EP1527775B1 (en) 1993-05-10 1994-04-29 Controlled release formulation containing tramadol
FI942092A FI942092A (en) 1993-05-10 1994-05-06 The controlled-release preparation
CA 2123160 CA2123160C (en) 1993-05-10 1994-05-09 Controlled release formulation
JP9667194A JP3045924B2 (en) 1993-05-10 1994-05-10 Oral pharmaceutical formulation release was adjusted
CN 94105356 CN1094755C (en) 1993-05-10 1994-05-10 Controlled release agent containing reamine benzene ring alcohol or it salt
US08241129 US5591452A (en) 1993-05-10 1994-05-10 Controlled release formulation
DK94304144T DK0636370T4 (en) 1993-07-01 1994-06-09 Depot preparations containing morphine
ES94304144T ES2124372T5 (en) 1993-07-01 1994-06-09 Sustained release compositions containing morphine.
EP19940304144 EP0636370B2 (en) 1993-07-01 1994-06-09 Sustained release compositions containing morphine
DE1994614046 DE69414046D1 (en) 1993-07-01 1994-06-09 Morphine-containing drug compositions sustained release
DE1994614046 DE69414046T3 (en) 1993-07-01 1994-06-09 Morphine-containing drug compositions sustained release
FI943141A FI114285B (en) 1993-07-01 1994-06-30 Process for the preparation of slow release pharmaceutical dosage unit form
CA 2127166 CA2127166C (en) 1993-07-01 1994-06-30 Sustained release morphine compositions and a method of preparation
JP15121994A JP3647897B2 (en) 1993-07-01 1994-07-01 Sustained-release unit dosage form
KR19940015740A KR100365572B1 (en) 1993-07-01 1994-07-01 Production method of sustained-release compositions and pharmaceutical compositions
EP19940308493 EP0654263B1 (en) 1993-11-23 1994-11-17 Method for preparing a sustained release composition
DE1994629710 DE69429710D1 (en) 1993-11-23 1994-11-17 A process for preparing a pharmaceutical composition having sustained-release
DK94308493T DK0654263T3 (en) 1993-11-23 1994-11-17 A process for the preparation of a composition with sustained-release
ES94308493T ES2168290T3 (en) 1993-11-23 1994-11-17 Method for preparing a sustained release composition.
DE1994629710 DE69429710T2 (en) 1993-11-23 1994-11-17 A process for preparing a pharmaceutical composition having sustained-release
FI945476A FI113335B (en) 1993-11-23 1994-11-22 Process for the preparation of pharmaceutical compositions useful in the particles
CN 94118503 CN1121213C (en) 1993-11-23 1994-11-23 Method of preparing sustained release compositions
JP28993694A JP3411114B2 (en) 1993-11-23 1994-11-24 Method for producing a sustained release composition and pharmaceutical compositions
US08449772 US6326027B1 (en) 1993-05-10 1995-05-24 Controlled release formulation
US08607851 US5891471A (en) 1993-11-23 1996-02-27 Pharmaceutical multiparticulates
US08607852 US5849240A (en) 1993-11-23 1996-02-27 Method of preparing sustained release pharmaceutical compositions
US08677798 US6254887B1 (en) 1993-05-10 1996-07-10 Controlled release tramadol
US08843571 US5879705A (en) 1993-07-27 1997-04-18 Sustained release compositions of morphine and a method of preparing pharmaceutical compositions
US08944106 US5965163A (en) 1993-11-23 1997-09-30 Substained release compositions and a method of preparing pharmaceutical compositions
JP22971898A JP3267561B2 (en) 1993-05-10 1998-08-14 Tramadol or use and analgesic agents of the pharmaceutically acceptable salt thereof
US09264399 US6143328A (en) 1993-07-27 1999-03-08 Sustained release compositions and a method of preparing pharmaceutical compositions
CN 99106642 CN1146410C (en) 1993-05-10 1999-05-17 Controlled release formulation
US09370270 US6162467A (en) 1993-11-23 1999-08-09 Sustained release compositions and a method of preparing pharmaceutical compositions
US09740732 US20010019725A1 (en) 1993-11-23 2000-12-19 Sustained release compositions and a method of preparing pharmaceutical compositions
US09800204 US7074430B2 (en) 1993-05-10 2001-03-06 Controlled release tramadol tramadol formulation
JP2001297270A JP3443574B2 (en) 1993-05-10 2001-09-27 Tramadol or analgesic agent containing the salt
JP2002271157A JP2003113075A (en) 1993-11-23 2002-09-18 Sustained release composition
FI20030560A FI121565B (en) 1993-05-10 2003-04-14 Process for the preparation of a controlled release preparation of tramadol
US11435015 US20060269603A1 (en) 1993-05-10 2006-05-16 Controlled release tramadol formulations
US12152474 US20090117191A1 (en) 1993-05-10 2008-05-14 Controlled release tramadol formulations
FI20105856A FI122717B (en) 1993-05-10 2010-08-17 A process for preparing a controlled release preparation of tramadol hydrochloride

Publications (3)

Publication Number Publication Date
GB9324045D0 GB9324045D0 (en) 1994-01-12
GB2284760A true GB2284760A (en) 1995-06-21
GB2284760B true GB2284760B (en) 1998-06-24

Family

ID=10745553

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9324045A Expired - Lifetime GB2284760B (en) 1993-11-23 1993-11-23 A method of preparing pharmaceutical compositions by melt pelletisation

Country Status (1)

Country Link
GB (1) GB2284760B (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843480A (en) 1994-03-14 1998-12-01 Euro-Celtique, S.A. Controlled release diamorphine formulation
US5849240A (en) 1993-11-23 1998-12-15 Euro-Celtique, S.A. Method of preparing sustained release pharmaceutical compositions
US5891471A (en) 1993-11-23 1999-04-06 Euro-Celtique, S.A. Pharmaceutical multiparticulates
US5958452A (en) 1994-11-04 1999-09-28 Euro-Celtique, S.A. Extruded orally administrable opioid formulations
US6068855A (en) 1994-11-03 2000-05-30 Euro-Celtique S. A. Pharmaceutical composition containing a fusible carrier and method for producing the same
US7829120B2 (en) 2005-09-09 2010-11-09 Labopharm Inc. Trazodone composition for once a day administration
US7988998B2 (en) 2002-10-25 2011-08-02 Labopharm Inc. Sustained-release tramadol formulations with 24-hour efficacy
US8487002B2 (en) 2002-10-25 2013-07-16 Paladin Labs Inc. Controlled-release compositions

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998000143A1 (en) * 1996-06-28 1998-01-08 Knoll Pharmaceutical Company Slow release pharmaceutical compositions and methods of making same
DE19918325A1 (en) 1999-04-22 2000-10-26 Euro Celtique Sa Extruded drug dosage form, e.g. granulate for tableting, comprising an active agent in a polysaccharide-containing matrix, giving a release profile which is controllable by extrusion conditions and/or the inclusion of additives
US7122143B2 (en) 2001-09-28 2006-10-17 Mcneil-Ppc, Inc. Methods for manufacturing dosage forms
EP1429724B1 (en) 2001-09-28 2013-11-06 McNeil-PPC, Inc. Dosage form containing a confectionery composition
US7838026B2 (en) 2001-09-28 2010-11-23 Mcneil-Ppc, Inc. Burst-release polymer composition and dosage forms comprising the same
US7807197B2 (en) 2002-09-28 2010-10-05 Mcneil-Ppc, Inc. Composite dosage forms having an inlaid portion
US8673352B2 (en) 2005-04-15 2014-03-18 Mcneil-Ppc, Inc. Modified release dosage form

Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3634584A (en) * 1969-02-13 1972-01-11 American Home Prod Sustained action dosage form
US4132753A (en) * 1965-02-12 1979-01-02 American Cyanamid Company Process for preparing oral sustained release granules
EP0108218A2 (en) * 1982-10-08 1984-05-16 Verex Laboratories, Inc. Constant release rate solid oral dosage formulation of pharmaceutical compounds having a high degree of water solubility
EP0271193A2 (en) * 1986-10-31 1988-06-15 Euroceltique S.A. Controlled release hydromorphone composition
EP0377518A2 (en) * 1989-01-06 1990-07-11 F.H. FAULDING & CO. LIMITED Sustained release pharmaceutical composition
WO1992001446A1 (en) * 1990-07-20 1992-02-06 Aps Research Limited Sustained-release formulations
WO1992002209A1 (en) * 1990-07-31 1992-02-20 Aiache Jean Marc Method for preparing a bioadhesive galenical and galenical thereby obtained
WO1992006679A1 (en) * 1990-10-16 1992-04-30 Kabi Pharmacia Ab A method for drug formulation and a pharmaceutical composition
EP0548448A1 (en) * 1991-12-24 1993-06-30 Euro-Celtique S.A. Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer
WO1993018753A1 (en) * 1992-03-20 1993-09-30 Kabi Pharmacia Ab Process for the preparation of sustained release pellets
WO1994003161A1 (en) * 1992-07-29 1994-02-17 Gacell Laboratories Ab Controlled release morphine preparation
EP0636370A1 (en) * 1993-07-01 1995-02-01 Euro-Celtique S.A. Sustained release compositions containing morphine
GB2281204A (en) * 1993-07-27 1995-03-01 Euro Celtique Sa Sustained release morphine compositions
EP0582380B1 (en) * 1992-06-26 1996-09-04 McNEIL-PPC, INC. Dry granulation using a fluidized bed

Patent Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4132753A (en) * 1965-02-12 1979-01-02 American Cyanamid Company Process for preparing oral sustained release granules
US3634584A (en) * 1969-02-13 1972-01-11 American Home Prod Sustained action dosage form
EP0108218A2 (en) * 1982-10-08 1984-05-16 Verex Laboratories, Inc. Constant release rate solid oral dosage formulation of pharmaceutical compounds having a high degree of water solubility
EP0271193A2 (en) * 1986-10-31 1988-06-15 Euroceltique S.A. Controlled release hydromorphone composition
EP0377518A2 (en) * 1989-01-06 1990-07-11 F.H. FAULDING & CO. LIMITED Sustained release pharmaceutical composition
WO1992001446A1 (en) * 1990-07-20 1992-02-06 Aps Research Limited Sustained-release formulations
WO1992002209A1 (en) * 1990-07-31 1992-02-20 Aiache Jean Marc Method for preparing a bioadhesive galenical and galenical thereby obtained
WO1992006679A1 (en) * 1990-10-16 1992-04-30 Kabi Pharmacia Ab A method for drug formulation and a pharmaceutical composition
EP0548448A1 (en) * 1991-12-24 1993-06-30 Euro-Celtique S.A. Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer
WO1993018753A1 (en) * 1992-03-20 1993-09-30 Kabi Pharmacia Ab Process for the preparation of sustained release pellets
EP0582380B1 (en) * 1992-06-26 1996-09-04 McNEIL-PPC, INC. Dry granulation using a fluidized bed
WO1994003161A1 (en) * 1992-07-29 1994-02-17 Gacell Laboratories Ab Controlled release morphine preparation
EP0636370A1 (en) * 1993-07-01 1995-02-01 Euro-Celtique S.A. Sustained release compositions containing morphine
GB2281204A (en) * 1993-07-27 1995-03-01 Euro Celtique Sa Sustained release morphine compositions

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
British National Formulary No.25 (March 1993) page 181-see MST Continus *
Curr.Ther.Res.47 pages 869-878 (1990) *

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849240A (en) 1993-11-23 1998-12-15 Euro-Celtique, S.A. Method of preparing sustained release pharmaceutical compositions
US5891471A (en) 1993-11-23 1999-04-06 Euro-Celtique, S.A. Pharmaceutical multiparticulates
US5965163A (en) 1993-11-23 1999-10-12 Euro-Celtique, S.A. Substained release compositions and a method of preparing pharmaceutical compositions
US6162467A (en) 1993-11-23 2000-12-19 Euro-Celtique, S.A. Sustained release compositions and a method of preparing pharmaceutical compositions
US5843480A (en) 1994-03-14 1998-12-01 Euro-Celtique, S.A. Controlled release diamorphine formulation
US6068855A (en) 1994-11-03 2000-05-30 Euro-Celtique S. A. Pharmaceutical composition containing a fusible carrier and method for producing the same
US5965161A (en) 1994-11-04 1999-10-12 Euro-Celtique, S.A. Extruded multi-particulates
US6706281B2 (en) 1994-11-04 2004-03-16 Euro-Celtique, S.A. Melt-extrusion multiparticulates
US6261599B1 (en) 1994-11-04 2001-07-17 Euro-Celtique, S.A. Melt-extruded orally administrable opioid formulations
US5958452A (en) 1994-11-04 1999-09-28 Euro-Celtique, S.A. Extruded orally administrable opioid formulations
US6335033B2 (en) 1994-11-04 2002-01-01 Euro-Celtique, S.A. Melt-extrusion multiparticulates
US7988998B2 (en) 2002-10-25 2011-08-02 Labopharm Inc. Sustained-release tramadol formulations with 24-hour efficacy
US8487002B2 (en) 2002-10-25 2013-07-16 Paladin Labs Inc. Controlled-release compositions
US7829120B2 (en) 2005-09-09 2010-11-09 Labopharm Inc. Trazodone composition for once a day administration
US8414919B2 (en) 2005-09-09 2013-04-09 Angelini Labopharm, Llc Sustained drug release composition
US8795723B2 (en) 2005-09-09 2014-08-05 Angelini Pharma Inc. Sustained drug release compositions
US8962019B2 (en) 2005-09-09 2015-02-24 Angelini Pharma, Inc. Sustained drug release composition
US9439866B2 (en) 2005-09-09 2016-09-13 Angelini Pharma, Inc. Trazodone composition for once a day administration

Also Published As

Publication number Publication date Type
GB9324045D0 (en) 1994-01-12 grant
GB2284760A (en) 1995-06-21 application

Similar Documents

Publication Publication Date Title
EP0582201A3 (en) Process for the preparation of glycerincarbonate
GB2284760B (en) A method of preparing pharmaceutical compositions by melt pelletisation
RU2002771C1 (en) Method for caked sitalls production
GB9304531D0 (en) Process for forming water-tight joint
GB2234169B (en) A method for preparing a sustained-release pharmaceutical peptide composition
GB2278519B (en) A system for time synchronisation
RU1806993C (en) Method for production potassium fluorine-borate
KR100181585B1 (en) Novel process preparing di-cyandiamide derivatives
CA2100836A1 (en) Pharmaceutical Composition
GB9215499D0 (en) Pharmaceuticals
GB9221446D0 (en) Pharmaceuticals
GB9223136D0 (en) Pharmaceuticals
GB9204565D0 (en) Pharmaceuticals
GB9221766D0 (en) Pharmaceuticals
GB9205918D0 (en) Pharmaceuticals
GB9221445D0 (en) Pharmaceuticals
GB9205363D0 (en) Pharmaceuticals
GB9218846D0 (en) Pharmaceuticals
GB9219356D0 (en) Pharmaceuticals
GB9205917D0 (en) Pharmaceuticals
GB9208434D0 (en) Pharmaceuticals
GB9222848D0 (en) Pharmaceuticals
GB9207414D0 (en) Pharmaceuticals
GB9211072D0 (en) Pharmaceuticals
GB9205428D0 (en) Pharmaceuticals

Legal Events

Date Code Title Description
PE20 Patent expired after termination of 20 years

Expiry date: 20131122