US3604417A - Osmotic fluid reservoir for osmotically activated long-term continuous injector device - Google Patents

Osmotic fluid reservoir for osmotically activated long-term continuous injector device Download PDF

Info

Publication number
US3604417A
US3604417A US3604417DA US3604417A US 3604417 A US3604417 A US 3604417A US 3604417D A US3604417D A US 3604417DA US 3604417 A US3604417 A US 3604417A
Authority
US
United States
Prior art keywords
chamber
piston
solvent
medicament
semipermeable membrane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
Inventor
Sidney Joseph Stolzenberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
UPPER MAKEFIELD TOWNSHIP
Original Assignee
Wyeth Holdings LLC
UPPER MAKEFIELD TOWNSHIP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Holdings LLC, UPPER MAKEFIELD TOWNSHIP filed Critical Wyeth Holdings LLC
Priority to US2413670A priority Critical
Application granted granted Critical
Publication of US3604417A publication Critical patent/US3604417A/en
Anticipated expiration legal-status Critical
Application status is Expired - Lifetime legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M3/00Medical syringes, e.g. enemata; Irrigators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/145Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/145Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/14526Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons the piston being actuated by fluid pressure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/145Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M2005/14513Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons with secondary fluid driving or regulating the infusion

Abstract

An improved osmotic pressure actuated injection device for long term continuous injection which has a chamber filled with the medicament to be injected and a suitable injection orifice, with a piston or similar device, the other side of he piston being a concentrated solution, such as a saturated solution, caPped with a semipermeable membrane and exposed to a second chamber having the solvent for the solution, and a freely movable piston exposed on its other side to atmospheric pressure or similar source so that the solvent moves through the semipermeable membrane increasing the osmotic pressure and so forcing the piston in the first chamber to discharge a small amount of medicament. The pressure in the solvent chamber is maIntained constant, thus preventing formation of air pockets therein.

Description

United States Patent [72] lmcntor Sidney Joseph Stolzenberg Yardley; Wayne Henry Linkenheimer l pper Makefield Township, Bucks County.

both of. Pa;

[211 App). No 24.136

[22] Filed Mar.31,l970

[45] Patented Sept. 14. 1971 [731 Assignee American Cyanamid Company Stamford, Conn.

[54] OSMOTIC FLUID RESERVOIR FOR OSMOTIC ALLY ACTIVATED LONG-TERM CONTINUOUS INJECTOR DEVICE 2 Claims, 2 Drawing Figs.

[52] 11.8. C1 128/213, 128/225. 128/260,128/218 R, [28/218 A, 222/389 [51] Int. Cl A61m 05/00 [50] Fieldof Search 128/213,

214,215, 216, 218 R, 218 A,218 P, 225,260, 261, 1; 222/389, 399; 169/7, 27, 32, 33; 3/1

Primary Examiner-Dalton L. Truluck AttorneyNorton S. Johnson ABSTRACT: An improved osmotic pressure actuated injection device for long term continuous injection which has a chamber filled with the medicament to be injected and a suitable injection orifice, with a piston or similar device, the other side of he piston being a concentrated solution, such as a saturated solution, caPped with a semipermeable membrane and exposed to a second chamber having the solvent for the solution, and a freely movable piston exposed on its other side to atmospheric pressure or similar source so that the solvent moves through the semipermeable membrane increasing the osmotic pressure and so forcing the piston in the first chamber to discharge a small amount of medicament. The pressure in the solvent chamber is malntained constant, thus preventing formation of air pockets therein.

PATENTEU SEP'l 4191: 3604.417

INVENTORS. S/DNEY JOSEPH $7OLZENBERG WAYNE HENRY L/NKENHE/MER VMZVJW k ATTORNEY OSMOTIC FLUID RESERVOIR FOR OSMOTICALLY ACTIVATED LONG-TERM CONTINUOUS INJECTOR DEVICE BACKGROUND OF THE INVENTION Long-term, continuous injector devices have been developed for gradual administration of medicaments over a considerable time, such as the administration of anticancer agents, long continued administration of contraceptive drugs, and like, using gas pressure from electrolytic decomposition of water, which is not accurate, and also those that have been actuated by osmotic pressure. Normally the osmotic pressure devices have been supplied with flexible reservoirs, such as plastic bags and the like, and this has caused considerable problems, not only from the standpoint of size which makes it unsuitable for implanting in a patient and particularly in veterinary cases in an animal, but also, the tendency of air or gas bubbles to form as the solvent fiows out of the reservoir into the concentrated or saturated solution has resulted in a lowering of pressure so that the final pressure on the medicament became insufficient.

SUMMARY OF THE INVENTION The present invention utilizes an orifice, chamber with a piston in it containing medicament, and on the other side of the piston a concentrated or saturated solution as has been used before. However, instead of a bag containing the osmotic solvent, this is contained in another chamber which screws onto the first chamber, of course being separated from the osmotic pressure solution by a conventional semipermeable osmotic membrane, and it also contains a piston which can freely slide, the other side of the piston either being connected to atmospheric pressure or to some other constant gentle pressure so that as the osmotic solvent gradually passes through the semipermeable membrane the piston slides and prevents formation of any gas voids. Atmospheric pressure is a very desirable and simple form of maintaining the piston in continuous contact with the osmotic solvent; however, other things, such as springs or other devices, may be used.

Since the two chambers are rigid, usually of a metal or strong plastic, the operation is independent of movements of a human or animal in whom it is implanted or to whom it is attached, and this is a very important characteristic, which maintains the pressure on the osmotic solution constant for long periods of time (for example as long as 1 month or more). This assures a continuous maintenance of an unbroken layer of osmotic solvent across the membrane surface regardless of the position of the subject and no gas voids can form in the reservoir, which automatically and continuously adjusts its volume by the movement of the piston to compensate for the diminishing volume of reservoir solvent during operation of the device. A long continued, gradual release of medicament, which can be at a rate as low as 0.12 ml. per day, can be maintained, and the device of the present invention therefore avoids all of the disadvantages or drawbacks of the osmotic pressure actuated injectors used hitherto.

The nature of the material of which the two chambers are formed and of the pistons is not critical. Of course the chambers must be of a material which is compatible with mammalian tissue if it is to be implanted, but otherwise any material which is sufficiently strong to maintain its shape and freesliding fits for the two pistons may be used. For many uses, particularly where the device is attached to the patient or animal, atmospheric pressure to maintain a constant pressure on the osmotic solvent is the simplest and cheapest.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a section through a chamber containing the osmotic pressure solvent, and

FIG. 2 is a similar section showing the osmotic solvent chamber screwed onto the medicament dispensing chamber.

DESCRIPTION OF THE PREFERRED EMBODIMENTS The preferred embodiments will be described first generally in conjunction with the drawing followed by some specific examples giving the details of the loading and use of the instrument.

FIG. 1 shows the osmotic pressure solvent chamber at I with one chamber 2 filled with the osmotic pressure solvent and a sliding free piston 4 which is capable of sliding in the circular device. Lips 3 prevent the piston from leaving the chamber.

The chamber 2 has a threaded outlet 5 at one end, and in the modification shown in FIG. 1 an outlet to the atmosphere on the other end of the device, the chamber 6, which is on the other side of the piston 4. Connection to the atmosphere can be through any suitable conduit, such as a flexible elastomer if the device is embedded in the patient or animal. If it is desired to have a closed device, the end of the chamber 3 is closed, as is shown in dashed lines as an optional structure 7.

FIG. 2 shows the threaded opening 5 from the chamber 2 screwed onto external threads on a medicament dispensing vessel 8. This dispensing vessel contains a freely sliding piston 10, and a dispensing orifice 9 to which can be connected a short piece of hypodermic needle, a plastic or silastic tubing or similar device. The piston divides the device into two chambers, 11 and 12. The former is filled with the medicament which is to be gradually injected over a long period and the chamber 12 contains a concentrated solution of a suitable osmotic pressure developing solution, for example one constituting a saturated solution of the dyestuff Congo Red, (3,3 [4,4-biphenylenebis (azo)]bis (4-amino-l-naphthalene sulfonic acid, disodium salt). Continued saturation is provided by having some of the material present in solid form, not shown.

The chamber 12 at the end opposite the piston 10 is closed by a semipermeable membrane 14 which is clamped tightly against the end of the chamber by the clamping member 15 which shows onto a threaded shoulder 16. In the chamber 2 there is the same solvent which is used to form the solution in the chamber 12. The nature of the particular solvent is not critical as it is not contacted with the medicament or with the tissues of the patient or animal, and it may be any suitable, stable liquid. In the case of the Congo Red solution, water is a very suitable solvent. In chamber 2 water is present or, if desired, a much more dilute solution of the Congo Red. In addition to the solids mentioned above in the chamber 12, a ball of metal or noncorrodible material, such as ceramic, 17 may be provided, which will keep the saturated Congo Red solution dispersed as a result of the normal movements of the patient or animal which causes the ball to move around and to stir the solution in chamber 12 gently.

As osmotic pressure slowly and gradually builds up in chamber 12, the piston 10 moves and displaces an equal amount of medicament in chamber 11 through the orifice 9. The volume of chamber I2 of course increases as a result of the osmotic flow of solvent from chamber 2 through the semipermeable membrane 14, and a constant gentle pressure is therefore maintained on the piston 10, which results in a very slow and continuous injection of the medicament. As solvent, such as water, passes out from chamber 2 through the semipermeable membrane 14, the piston 4 moves in slightly, under atmospheric pressure in the case of this modification, or under pneumatic pressure where a closed chamber is utilized. The chamber 2, therefore, cannot develop any gas voids and there is maintained therein a gentle pressure suitable for continuous passage of solvent through the membrane. It will be noted that the piston 4 always assures that there is a constant liquid layer at the interface between the semipermeable membrane I4 and the osmotic pressure solvent in the chamber 2, and this is maintained regardless of the position of the patient or the animal in or on which the injection device is mounted.

After a long period of continuous injection, the medicament in the chamber 11 becomes exhausted and the device can then be removed from the patient or animal and after suitable cleaning and resterilizing, refilled with medicament and osmotic pressure solvent.

Where the host is immobilized it may be desirable to actuate the magnetized balls in the Congo Red compartment 12. To this end there may be provided a microtiming device, connected to two small magnets spaced exteriorly of the injector and at opposite ends of compartment 12, shown in FIG. 2. At timed intervals the balls are thus caused to roll from one end of the compartment to the other causing agitation of the Congo Red solution suspension.

EXAMPLE 1 A 2% cc. plastic disposable syringe manufactured by Becton-Dickinson, was cut off at the 2 cc. mark. The plastic handle of the piston was removed and the remaining rubber plug was placed so that the syringe would hold a volume of 1 cc. of medicament. The remainder of the syringe contained about 0.8 gm. Congo Red and two stainless steel balls. This was covered by a sheet of semipermeable membrane obtained from a Visking dialysis sac. The membrane covered this opening tightly and the ends were folded back securely. A hollow cylinder obtained from a 5 cc. syringe of the same type, out between the and 3 cc. marks, was inserted over the ends of the semipermeable membrane. An airtight seal was made between the two plastic syringes with Dow-Corning medical grade Elastomer. The Elastomer hardened with a few minutes and supported the semipermeable membrane as well. At the other end of the cylinder the rubber plug from the 5 cc. syringe was inserted and the opening behind the plug was covered with a plastic cap with a small opening in the center. The plastic cap was sealed in place behind the 5 cc. syringe with Elastomer.

To activate the device, two hypodermic needles were inserted through the plastic walls on each side of the semipermeable membrane. These were filled with distilled water so as to exclude air bubbles on either side. The holes caused by the hypodermic needles were sealed with elastomer. The compartment designed to hold the medicament was filled with a 0.] percent methylene blue solution by means of a thin caliber hypodermic needle inserted through the opening.

The device successfully constructed was tested in an in vitro system. It was warmed at 37 C. in a water bath contained in a Dubnoff shaker. The entire 1 cc. of methylene blue was expelled within 2% to 3 hours. When a plastic ring was glued next to the semipermeable membrane such that the diameter of the membrane exposed to fluids was about 3 mm., less than I cc. of the methylene blue solution was injected after a week. It was about 0.12 cc. of solution was expelled per day. The decline in volume of methylene blue could be observed from day to day.

EXAMPLE 2 It should be emphasized that a high purity Congo Red, free of contaminating ions or compounds of low molecular weight, is essential, Contaminating molecules diffuse across the semipermeable membrane and nullify or reduce the effective osmotic gradient.

The device is constructed as shown in FIG. 2 However, a percent solution suspension of Congo Red is used. In our recent experiments higher concentrations tended to congeal and eventually appeared gelatinous. The Congo Red compart ment was filled and five stainless steel balls of about 1.5 mm. diameter were added. The compartment was covered with a Visking semipermeable membrane with a thickness of 0.0008 inch. The water compartment obtained from a 5 cc. syringe was sealed in place as previously described, using Caulk Grip dental cement instead of Elastomer. Two drops of distilled water was added and the water compartment was covered with the rubber plunger from the 5 cc. syringe for storage before use.

To activate an injector device, the rubber plunger was removed and the water compartment filled with distilled water. A 24-gauge hypodermic needle was inserted through the plunger. The plunger was reinserted into the 5 cc. syringe, allowing the excess water to flow out through the hypodermic needle. Both the Congo Red and water compartments were free of air bubbles. The opening behind the plug was covered with a snugly fitting plastic cap with an opening in the center measuring about 3 mm. in diameter. The medicament compartment was filled with water.

Two in vitro experiments were carried out in a Dubnoff shaker by placing the devices in a water bath at 37 with mild but continuous agitation. The results obtained with six injector devices are listed in table 1. Two injector devices were fastened on the backs of two sheep in an area previously shaved to remove the wool. The devices were held in place with adhesive tape and branding cement. The results are shown in table 2.

TABLE 1 Injector N 0.

Day Time 1 1 2 1 3 1 1 0900 1. 03 1. 03 1.03 1030 0. 95 0. 9O 0. 88 1115 0. 0.83 0. 78 1215 0. T5 0. 70 0. 67 1325 O. 65 0. 63 0. 58 1520 0. 50 0. 50 0. 45 1630 0. 45 0. 43 0 37 M1. solution remaining in medicament compartment.

2 There was a large bubble in water compartment observed at this time which probably lnterferred with osmosis.

M1. solution remaining in medicament compartment.

We claim:

1. in a continuous, long-term injector device, which comprises a hollow member with injection orifice at one end adapted for connection with body tissue, a slidable piston in the member dividing it into first and second chambers and a semipermeable membrane across the end of said second chamber, the second chamber being filled with an osmotic pressure developing solution and the 69 chamber containing a medicament, the improvement which comprises,

a. a second hollow member serving as a reservoir for osmotic pressure solvent and provided with a freely sliding piston,

b. screw-threaded means securing the reservoir onto the hollow member of the injector device to maintain continuous contact of the osmotic pressure solvent with the semipermeable membrane, and

2. A injector device according to claim 1 in which the source of at least ambient pressure is the atmosphere.

UNITED STATES PATENT OFFICE CERTIFICATE OF CORRECTION Patent No. 5,604,417 Dated September 14, 1971 Inventor) Sidney Joseph Stolzenberg & Wayne Henry Linkenheimer It is certified that error appears in the above-identified patent and that said Letters Patent are hereby corrected as shown below:

Abstract of the Disclosure, line 5, "he" should read the Abstract of the Disclosure, line 6, "caPped" should read capped Abstract of the Disclosure, line 15, "maIntained" should read maintained Column 1, line 12 "and like" should read and the like Column 2, line 58 "shows' should read screws Column 5, line 5 after "medicament" insert and osmotic pressure developing solution Column 5, line 59 should read after essential.

Column 4, line 6'? "69" should read first Signed and sealed this 18th day of April 1972.

{ EAL) l L to s L EDWARD ILFIJSICIHERJR. ROBERT GOTTSCHALK A ttesting Officer Commissioner of Patents QM PO-1050H0-69) USCOMM-DC 60376-F'B9 Q U 5 GOVERNMENT FRINHNG OFFICE I969 0366334

Claims (2)

1. In a continuous, long-term injector device, which comprises a hollow member with injection orifice at one end adapted for connection with body tissue, a slidable piston in the member dividing it into first and second chambers and a semipermeable membrane across the end of said second chamber, the second chamber being filled with an osmotic pressure developing solution and the 69 chamber containing a medicament, the improvement which comprises, a. a second hollow member serving as a reservoir for osmotic pressure solvent and provided with a freely sliding piston, b. screw-threaded means securing the reservoir onto the hollow member of the injector device to maintain continuous contact of the osmotic pressure solvent with the semipermeable membrane, and c, means for exposing the side of the sliding piston in the reservoir out of contact with solvent to a source of at least ambient pressure.
2. A injector device according to claim 1 in which the source of at least ambient pressure is the atmosphere.
US3604417D 1970-03-31 1970-03-31 Osmotic fluid reservoir for osmotically activated long-term continuous injector device Expired - Lifetime US3604417A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US2413670A true 1970-03-31 1970-03-31

Publications (1)

Publication Number Publication Date
US3604417A true US3604417A (en) 1971-09-14

Family

ID=21819040

Family Applications (1)

Application Number Title Priority Date Filing Date
US3604417D Expired - Lifetime US3604417A (en) 1970-03-31 1970-03-31 Osmotic fluid reservoir for osmotically activated long-term continuous injector device

Country Status (1)

Country Link
US (1) US3604417A (en)

Cited By (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3732865A (en) * 1971-01-13 1973-05-15 Alza Corp Osmotic dispenser
US3760984A (en) * 1971-09-29 1973-09-25 Alza Corp Osmotically powered agent dispensing device with filling means
US3760806A (en) * 1971-01-13 1973-09-25 Alza Corp Helical osmotic dispenser with non-planar membrane
US3760804A (en) * 1971-01-13 1973-09-25 Alza Corp Improved osmotic dispenser employing magnesium sulphate and magnesium chloride
US3786813A (en) * 1972-12-27 1974-01-22 Alza Corp Drug delivery device with self actuated mechanism for retaining device in selected area
US3788322A (en) * 1972-12-27 1974-01-29 Alza Corp Drug delivery device with means for maintaining device in environment of use
US3797492A (en) * 1972-12-27 1974-03-19 Alza Corp Device for dispensing product with directional guidance member
US3894538A (en) * 1972-08-10 1975-07-15 Siemens Ag Device for supplying medicines
US3896819A (en) * 1969-04-01 1975-07-29 Alejandro Zaffaroni IUD having a replenishing drug reservoir
US3929132A (en) * 1973-04-10 1975-12-30 Alza Corp Osmotic dispenser
US3987790A (en) * 1975-10-01 1976-10-26 Alza Corporation Osmotically driven fluid dispenser
US3995632A (en) * 1973-05-04 1976-12-07 Alza Corporation Osmotic dispenser
US3995631A (en) * 1971-01-13 1976-12-07 Alza Corporation Osmotic dispenser with means for dispensing active agent responsive to osmotic gradient
US4034756A (en) * 1971-01-13 1977-07-12 Alza Corporation Osmotically driven fluid dispenser
US4036228A (en) * 1975-09-11 1977-07-19 Alza Corporation Osmotic dispenser with gas generating means
US4147282A (en) * 1977-06-06 1979-04-03 Sidney Levy Vacuum actuated pressurized fluid dispenser
US4209014A (en) * 1977-12-12 1980-06-24 Canadian Patents And Development Limited Dispensing device for medicaments
WO1981001794A1 (en) * 1979-12-28 1981-07-09 S Ash System for demand-based administration of insulin
US4340048A (en) * 1981-03-28 1982-07-20 Alza Corporation Self-driven hypodermic injector
US4384581A (en) * 1980-01-17 1983-05-24 Becton, Dickinson And Company Microsyringe
US4474575A (en) * 1982-02-01 1984-10-02 Alza Corporation Self-driven pump assembly and method of operation
US4505701A (en) * 1982-05-17 1985-03-19 Navato Jose R Automatic parenteral infusion apparatus
US4539004A (en) * 1982-09-22 1985-09-03 Alza Corporation Self-driven pump assembly and method of operation
US4623330A (en) * 1982-02-16 1986-11-18 Laby Ralph H Gas diffusion-limited controlled release devices
EP0235691A2 (en) * 1986-02-26 1987-09-09 Hoechst Aktiengesellschaft Device for dispensing medicinal suspensions
EP0259013A1 (en) 1986-08-04 1988-03-09 Pharmetrix Corporation Portable controlled release osmotic infusion device
US4781688A (en) * 1986-04-04 1988-11-01 Herwig Thoma Dispensing device for a liquid medicament
EP0354742A2 (en) * 1988-08-09 1990-02-14 Pharmetrix Corporation Portable infusion device assembly
US5135500A (en) * 1989-10-31 1992-08-04 Prime Medical Products, Inc. Self-driven pump device
US5151093A (en) * 1990-10-29 1992-09-29 Alza Corporation Osmotically driven syringe with programmable agent delivery
US5234424A (en) * 1988-12-28 1993-08-10 Alza Corporation Osmotically driven syringe
US5279608A (en) * 1990-12-18 1994-01-18 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Osmotic pumps
US5341993A (en) * 1991-08-19 1994-08-30 Habley Hills Technology Corporation Topical sprayer with remotely actuated spray tip
US5540665A (en) * 1994-01-31 1996-07-30 Alza Corporation Gas driven dispensing device and gas generating engine therefor
US5651979A (en) * 1995-03-30 1997-07-29 Gel Sciences, Inc. Apparatus and method for delivering a biologically active compound into a biological environment
US20020007173A1 (en) * 1997-07-10 2002-01-17 Kundig Thomas M. Method of inducing a CTL response
WO2002085428A2 (en) * 2001-04-19 2002-10-31 Microsolutions, Inc. Implantable osmotic pump
US20030088204A1 (en) * 2001-11-02 2003-05-08 Joshi Ashok V Novel iontophoretic drug delivery systems
US6575930B1 (en) 1999-03-12 2003-06-10 Medrad, Inc. Agitation devices and dispensing systems incorporating such agitation devices
US6652489B2 (en) * 2000-02-07 2003-11-25 Medrad, Inc. Front-loading medical injector and syringes, syringe interfaces, syringe adapters and syringe plungers for use therewith
US20030232082A1 (en) * 2001-09-28 2003-12-18 Shun-Por Li Modified release dosage forms
WO2004011062A1 (en) * 2002-07-24 2004-02-05 Disetronic Licensing Ag Administration device comprising an osmotic drive
US6706020B1 (en) 1998-08-28 2004-03-16 Schering Aktiengesellschaft Syringes and injectors incorporating magnetic fluid agitation devices
US20040078986A1 (en) * 2002-08-21 2004-04-29 Eveready Battery Company, Inc. Razor having a microfluidic shaving aid delivery system and method of ejecting shaving aid
US6733478B2 (en) 1992-08-17 2004-05-11 Medrad, Inc. System and method for providing information from a syringe to an injector
US6775570B2 (en) 2002-02-04 2004-08-10 Ceramatec, Inc. Iontophoretic treatment device
US20040193071A1 (en) * 2003-03-28 2004-09-30 Ethicon, Inc. Tissue collection device and methods
US6808513B2 (en) 1992-08-17 2004-10-26 Medrad, Inc. Front loading medical injector and syringe for use therewith
US20040230183A1 (en) * 2003-02-18 2004-11-18 Wisam Breegi Drug delivery device and syringe for filling the same
US6958053B1 (en) 1999-11-24 2005-10-25 Medrad, Inc. Injector providing drive member advancement and engagement with syringe plunger, and method of connecting a syringe to an injector
US6966894B1 (en) 1998-08-28 2005-11-22 Schering Aktiengesellschaft Syringes and injectors incorporating mechanical fluid agitation devices
US6994851B1 (en) 1997-07-10 2006-02-07 Mannkind Corporation Method of inducing a CTL response
US7047069B2 (en) 2002-02-04 2006-05-16 Ceramatec, Inc. Iontophoretic fluid delivery device
US20060153844A1 (en) * 2004-12-29 2006-07-13 Thomas Kundig Methods to trigger, maintain and manipulate immune responses by targeted administration of biological response modifiers into lymphoid organs
US20060207883A1 (en) * 2004-10-19 2006-09-21 Koval Carl A Electrochemical high pressure pump
US20070148014A1 (en) * 2005-11-23 2007-06-28 Anex Deon S Electrokinetic pump designs and drug delivery systems
US20070163968A1 (en) * 2006-01-17 2007-07-19 Johnsondiversey, Inc. Method and apparatus for providing treatment chemicals to process water systems
US20080177219A1 (en) * 2007-01-23 2008-07-24 Joshi Ashok V Method for Iontophoretic Fluid Delivery
US7419478B1 (en) 2003-06-25 2008-09-02 Medrad, Inc. Front-loading syringe for medical injector having a flexible syringe retaining ring
US20080269725A1 (en) * 2005-07-22 2008-10-30 Trent Deem Osmotically Driven Dispense Pump and Related Components for Use in High Pressure Applications
EP2060286A1 (en) * 2007-11-13 2009-05-20 Acuros GmbH Osmotic pump
US7553294B2 (en) 2002-05-30 2009-06-30 Medrad, Inc. Syringe plunger sensing mechanism for a medical injector
US7611473B2 (en) 2003-09-11 2009-11-03 Ethicon, Inc. Tissue extraction and maceration device
US20110066116A1 (en) * 2009-08-21 2011-03-17 Becton Dickinson France S.A.S. Pre-Filled Active Vial Having Integral Plunger Assembly
US8034003B2 (en) 2003-09-11 2011-10-11 Depuy Mitek, Inc. Tissue extraction and collection device
US8197844B2 (en) 2007-06-08 2012-06-12 Activatek, Inc. Active electrode for transdermal medicament administration
US8715480B2 (en) 2002-10-18 2014-05-06 Eksigent Technologies, Llc Electrokinetic pump having capacitive electrodes
US8862223B2 (en) 2008-01-18 2014-10-14 Activatek, Inc. Active transdermal medicament patch and circuit board for same
US8979511B2 (en) 2011-05-05 2015-03-17 Eksigent Technologies, Llc Gel coupling diaphragm for electrokinetic delivery systems
US9108047B2 (en) 2010-06-04 2015-08-18 Bayer Medical Care Inc. System and method for planning and monitoring multi-dose radiopharmaceutical usage on radiopharmaceutical injectors
US9480797B1 (en) 2015-10-28 2016-11-01 Bayer Healthcare Llc System and method for syringe plunger engagement with an injector
US9694131B2 (en) 2003-11-25 2017-07-04 Bayer Healthcare Llc Medical injector system
US9744305B2 (en) 2012-09-28 2017-08-29 Bayer Healthcare Llc Quick release plunger
US9844622B2 (en) 2000-07-10 2017-12-19 Bayer Healthcare Llc Syringes for medical injector systems
US9855390B2 (en) 2006-03-15 2018-01-02 Bayer Healthcare Llc Plunger covers and plungers for use in syringes

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2690178A (en) * 1950-11-13 1954-09-28 Research Corp Automatic apparatus for administering drugs
US3023750A (en) * 1959-03-04 1962-03-06 Howard C Baron Self-generating pressure device for infusion administration systems
US3211431A (en) * 1961-09-27 1965-10-12 David M Meysembourg Method and apparatus for compounding desired concentrations
US3214067A (en) * 1962-09-11 1965-10-26 Thomas R Linington Fluid dispenser
US3313289A (en) * 1964-06-23 1967-04-11 Frank A Kapral Implant chamber
US3367545A (en) * 1965-09-15 1968-02-06 Products Res & Chemical Corp Gas-generating dispenser for viscous materials
US3527220A (en) * 1968-06-28 1970-09-08 Fairchild Hiller Corp Implantable drug administrator

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2690178A (en) * 1950-11-13 1954-09-28 Research Corp Automatic apparatus for administering drugs
US3023750A (en) * 1959-03-04 1962-03-06 Howard C Baron Self-generating pressure device for infusion administration systems
US3211431A (en) * 1961-09-27 1965-10-12 David M Meysembourg Method and apparatus for compounding desired concentrations
US3214067A (en) * 1962-09-11 1965-10-26 Thomas R Linington Fluid dispenser
US3313289A (en) * 1964-06-23 1967-04-11 Frank A Kapral Implant chamber
US3367545A (en) * 1965-09-15 1968-02-06 Products Res & Chemical Corp Gas-generating dispenser for viscous materials
US3527220A (en) * 1968-06-28 1970-09-08 Fairchild Hiller Corp Implantable drug administrator

Cited By (118)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3896819A (en) * 1969-04-01 1975-07-29 Alejandro Zaffaroni IUD having a replenishing drug reservoir
US4034756A (en) * 1971-01-13 1977-07-12 Alza Corporation Osmotically driven fluid dispenser
US3732865A (en) * 1971-01-13 1973-05-15 Alza Corp Osmotic dispenser
US3760806A (en) * 1971-01-13 1973-09-25 Alza Corp Helical osmotic dispenser with non-planar membrane
US3760804A (en) * 1971-01-13 1973-09-25 Alza Corp Improved osmotic dispenser employing magnesium sulphate and magnesium chloride
US3995631A (en) * 1971-01-13 1976-12-07 Alza Corporation Osmotic dispenser with means for dispensing active agent responsive to osmotic gradient
US3760984A (en) * 1971-09-29 1973-09-25 Alza Corp Osmotically powered agent dispensing device with filling means
US3894538A (en) * 1972-08-10 1975-07-15 Siemens Ag Device for supplying medicines
US3788322A (en) * 1972-12-27 1974-01-29 Alza Corp Drug delivery device with means for maintaining device in environment of use
US3786813A (en) * 1972-12-27 1974-01-22 Alza Corp Drug delivery device with self actuated mechanism for retaining device in selected area
US3797492A (en) * 1972-12-27 1974-03-19 Alza Corp Device for dispensing product with directional guidance member
US3929132A (en) * 1973-04-10 1975-12-30 Alza Corp Osmotic dispenser
US3995632A (en) * 1973-05-04 1976-12-07 Alza Corporation Osmotic dispenser
US4036228A (en) * 1975-09-11 1977-07-19 Alza Corporation Osmotic dispenser with gas generating means
US3987790A (en) * 1975-10-01 1976-10-26 Alza Corporation Osmotically driven fluid dispenser
US4147282A (en) * 1977-06-06 1979-04-03 Sidney Levy Vacuum actuated pressurized fluid dispenser
US4209014A (en) * 1977-12-12 1980-06-24 Canadian Patents And Development Limited Dispensing device for medicaments
WO1981001794A1 (en) * 1979-12-28 1981-07-09 S Ash System for demand-based administration of insulin
US4384581A (en) * 1980-01-17 1983-05-24 Becton, Dickinson And Company Microsyringe
US4340048A (en) * 1981-03-28 1982-07-20 Alza Corporation Self-driven hypodermic injector
US4474575A (en) * 1982-02-01 1984-10-02 Alza Corporation Self-driven pump assembly and method of operation
US4623330A (en) * 1982-02-16 1986-11-18 Laby Ralph H Gas diffusion-limited controlled release devices
US4505701A (en) * 1982-05-17 1985-03-19 Navato Jose R Automatic parenteral infusion apparatus
US4539004A (en) * 1982-09-22 1985-09-03 Alza Corporation Self-driven pump assembly and method of operation
EP0398397A1 (en) * 1986-02-26 1990-11-22 Hoechst Aktiengesellschaft Utilisation of the device for dispensing medical suspensions and procedure to obtain a homogeneous mixture of this suspension
EP0235691A2 (en) * 1986-02-26 1987-09-09 Hoechst Aktiengesellschaft Device for dispensing medicinal suspensions
EP0235691A3 (en) * 1986-02-26 1988-08-17 Hoechst Aktiengesellschaft Device for dispensing medicinal suspensions
US4781688A (en) * 1986-04-04 1988-11-01 Herwig Thoma Dispensing device for a liquid medicament
EP0259013A1 (en) 1986-08-04 1988-03-09 Pharmetrix Corporation Portable controlled release osmotic infusion device
US4838862A (en) * 1986-08-04 1989-06-13 Pharmetrix Corp. Portable controlled release osmotic infusion device
EP0354742A3 (en) * 1988-08-09 1990-07-25 Pharmetrix Corporation Portable infusion device assembly
EP0354742A2 (en) * 1988-08-09 1990-02-14 Pharmetrix Corporation Portable infusion device assembly
US5234424A (en) * 1988-12-28 1993-08-10 Alza Corporation Osmotically driven syringe
US5135500A (en) * 1989-10-31 1992-08-04 Prime Medical Products, Inc. Self-driven pump device
US5151093A (en) * 1990-10-29 1992-09-29 Alza Corporation Osmotically driven syringe with programmable agent delivery
US5312389A (en) * 1990-10-29 1994-05-17 Felix Theeuwes Osmotically driven syringe with programmable agent delivery
AT403884B (en) * 1990-12-18 1998-06-25 Sod Conseils Rech Applic osmotic pump
US5279608A (en) * 1990-12-18 1994-01-18 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Osmotic pumps
DE4141819B4 (en) * 1990-12-18 2004-08-19 Société de Conseils de Recherches et D'Applications Scientifiques (S.C.R.A.S.) osmotic pump
AU652199B2 (en) * 1990-12-18 1994-08-18 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Osmotic pumps
US5341993A (en) * 1991-08-19 1994-08-30 Habley Hills Technology Corporation Topical sprayer with remotely actuated spray tip
US6808513B2 (en) 1992-08-17 2004-10-26 Medrad, Inc. Front loading medical injector and syringe for use therewith
US7081105B2 (en) 1992-08-17 2006-07-25 Medrad, Inc. Injector system having a front loading pressure jacket assembly
US6733478B2 (en) 1992-08-17 2004-05-11 Medrad, Inc. System and method for providing information from a syringe to an injector
US5540665A (en) * 1994-01-31 1996-07-30 Alza Corporation Gas driven dispensing device and gas generating engine therefor
US5651979A (en) * 1995-03-30 1997-07-29 Gel Sciences, Inc. Apparatus and method for delivering a biologically active compound into a biological environment
US5935593A (en) * 1995-06-07 1999-08-10 Medlogic Global Corporation Chemo-mechanical expansion delivery system
US8372393B2 (en) 1997-07-10 2013-02-12 Mannkind Corporation Method of inducing a CTL response
US7364729B2 (en) 1997-07-10 2008-04-29 Mannkind Corporation Method of inducing a CTL response
US20060153858A1 (en) * 1997-07-10 2006-07-13 Kundig Thomas M Method of inducing a CTL response
US20090035252A1 (en) * 1997-07-10 2009-02-05 Kundig Thomas M Method of inducing a CTL response
US6994851B1 (en) 1997-07-10 2006-02-07 Mannkind Corporation Method of inducing a CTL response
US20020007173A1 (en) * 1997-07-10 2002-01-17 Kundig Thomas M. Method of inducing a CTL response
US6977074B2 (en) 1997-07-10 2005-12-20 Mannkind Corporation Method of inducing a CTL response
US6706020B1 (en) 1998-08-28 2004-03-16 Schering Aktiengesellschaft Syringes and injectors incorporating magnetic fluid agitation devices
US6966894B1 (en) 1998-08-28 2005-11-22 Schering Aktiengesellschaft Syringes and injectors incorporating mechanical fluid agitation devices
US7351221B2 (en) 1999-03-12 2008-04-01 Medrad, Inc. Container for agitating and injecting a multi-component medium
US6575930B1 (en) 1999-03-12 2003-06-10 Medrad, Inc. Agitation devices and dispensing systems incorporating such agitation devices
US7060049B2 (en) 1999-03-12 2006-06-13 Medrad, Inc. Injection system having an agitation mechanism for circulating a fluid medium
US20060184102A1 (en) * 1999-03-12 2006-08-17 Trombley Frederick W Iii Container for agitating and injecting a multi-component medium
US6958053B1 (en) 1999-11-24 2005-10-25 Medrad, Inc. Injector providing drive member advancement and engagement with syringe plunger, and method of connecting a syringe to an injector
US6652489B2 (en) * 2000-02-07 2003-11-25 Medrad, Inc. Front-loading medical injector and syringes, syringe interfaces, syringe adapters and syringe plungers for use therewith
US7540856B2 (en) 2000-02-07 2009-06-02 Medrad, Inc. Front-loading medical injector adapted to releasably engage a syringe regardless of the orientation of the syringe with respect to the injector
US9636452B2 (en) 2000-02-07 2017-05-02 Bayer Healthcare Llc Front-loading medical injector adapted to releasably engage a syringe regardless of the orientation of the syringe with respect to the injector
US8721596B2 (en) 2000-02-07 2014-05-13 Bayer Medical Care Inc. Front-loading syringe adapted to releasably engage a medical injector regardless of the orientation of the syringe with respect to the injector
US20170224913A1 (en) * 2000-02-07 2017-08-10 Bayer Healthcare Llc Front-Loading Medical Injector Adapted to Releasably Engage A Syringe Regardless of the Orientation of the Syringe With Respect to the Injector
US9844622B2 (en) 2000-07-10 2017-12-19 Bayer Healthcare Llc Syringes for medical injector systems
US20040249365A1 (en) * 2001-04-19 2004-12-09 Microsolutions, Inc. Implantable osmotic pump
US6632217B2 (en) * 2001-04-19 2003-10-14 Microsolutions, Inc. Implantable osmotic pump
WO2002085428A2 (en) * 2001-04-19 2002-10-31 Microsolutions, Inc. Implantable osmotic pump
US20030135202A1 (en) * 2001-04-19 2003-07-17 Microsolutions, Inc. Implantable osmotic pump
WO2002085428A3 (en) * 2001-04-19 2004-03-11 Microsolutions Inc Implantable osmotic pump
US20030232082A1 (en) * 2001-09-28 2003-12-18 Shun-Por Li Modified release dosage forms
US7349733B2 (en) 2001-11-02 2008-03-25 Ceramatel, Inc. Iontophoretic drug delivery systems
US20030088204A1 (en) * 2001-11-02 2003-05-08 Joshi Ashok V Novel iontophoretic drug delivery systems
US6775570B2 (en) 2002-02-04 2004-08-10 Ceramatec, Inc. Iontophoretic treatment device
US7047069B2 (en) 2002-02-04 2006-05-16 Ceramatec, Inc. Iontophoretic fluid delivery device
US8574200B2 (en) 2002-05-30 2013-11-05 Medrad, Inc. Dual syringe injector system
US7553294B2 (en) 2002-05-30 2009-06-30 Medrad, Inc. Syringe plunger sensing mechanism for a medical injector
US8133203B2 (en) 2002-05-30 2012-03-13 Medrad, Inc. Method of injecting fluids from a dual syringe injector system
WO2004011062A1 (en) * 2002-07-24 2004-02-05 Disetronic Licensing Ag Administration device comprising an osmotic drive
US20040078986A1 (en) * 2002-08-21 2004-04-29 Eveready Battery Company, Inc. Razor having a microfluidic shaving aid delivery system and method of ejecting shaving aid
US7103977B2 (en) 2002-08-21 2006-09-12 Eveready Battery Company, Inc. Razor having a microfluidic shaving aid delivery system and method of ejecting shaving aid
US8715480B2 (en) 2002-10-18 2014-05-06 Eksigent Technologies, Llc Electrokinetic pump having capacitive electrodes
US20040230183A1 (en) * 2003-02-18 2004-11-18 Wisam Breegi Drug delivery device and syringe for filling the same
US8562542B2 (en) 2003-03-28 2013-10-22 Depuy Mitek, Llc Tissue collection device and methods
US20040193071A1 (en) * 2003-03-28 2004-09-30 Ethicon, Inc. Tissue collection device and methods
US7794408B2 (en) * 2003-03-28 2010-09-14 Ethicon, Inc. Tissue collection device and methods
US7419478B1 (en) 2003-06-25 2008-09-02 Medrad, Inc. Front-loading syringe for medical injector having a flexible syringe retaining ring
US7998086B2 (en) 2003-09-11 2011-08-16 Depuy Mitek, Inc. Tissue extraction and maceration device
US8870788B2 (en) 2003-09-11 2014-10-28 Depuy Mitek, Llc Tissue extraction and collection device
US8034003B2 (en) 2003-09-11 2011-10-11 Depuy Mitek, Inc. Tissue extraction and collection device
US7611473B2 (en) 2003-09-11 2009-11-03 Ethicon, Inc. Tissue extraction and maceration device
US8585610B2 (en) 2003-09-11 2013-11-19 Depuy Mitek, Llc Tissue extraction and maceration device
US9694131B2 (en) 2003-11-25 2017-07-04 Bayer Healthcare Llc Medical injector system
US20060207883A1 (en) * 2004-10-19 2006-09-21 Koval Carl A Electrochemical high pressure pump
US7718047B2 (en) 2004-10-19 2010-05-18 The Regents Of The University Of Colorado Electrochemical high pressure pump
US20060153844A1 (en) * 2004-12-29 2006-07-13 Thomas Kundig Methods to trigger, maintain and manipulate immune responses by targeted administration of biological response modifiers into lymphoid organs
US9447781B2 (en) * 2005-07-22 2016-09-20 University Of Utah Research Foundation Osmotically driven dispense pump and related components for use in high pressure applications
US20080269725A1 (en) * 2005-07-22 2008-10-30 Trent Deem Osmotically Driven Dispense Pump and Related Components for Use in High Pressure Applications
US20070148014A1 (en) * 2005-11-23 2007-06-28 Anex Deon S Electrokinetic pump designs and drug delivery systems
US8794929B2 (en) * 2005-11-23 2014-08-05 Eksigent Technologies Llc Electrokinetic pump designs and drug delivery systems
US20070163968A1 (en) * 2006-01-17 2007-07-19 Johnsondiversey, Inc. Method and apparatus for providing treatment chemicals to process water systems
US9855390B2 (en) 2006-03-15 2018-01-02 Bayer Healthcare Llc Plunger covers and plungers for use in syringes
US20080177219A1 (en) * 2007-01-23 2008-07-24 Joshi Ashok V Method for Iontophoretic Fluid Delivery
US8197844B2 (en) 2007-06-08 2012-06-12 Activatek, Inc. Active electrode for transdermal medicament administration
US20090129945A1 (en) * 2007-11-13 2009-05-21 Acuros Gmbh Osmotic Pump
EP2060286A1 (en) * 2007-11-13 2009-05-20 Acuros GmbH Osmotic pump
US8322993B2 (en) 2007-11-13 2012-12-04 Acuros Gmbh Osmotic pump comprising a pressure device for pressurizing the solvent
US8862223B2 (en) 2008-01-18 2014-10-14 Activatek, Inc. Active transdermal medicament patch and circuit board for same
US20110066116A1 (en) * 2009-08-21 2011-03-17 Becton Dickinson France S.A.S. Pre-Filled Active Vial Having Integral Plunger Assembly
US9375385B2 (en) 2009-08-21 2016-06-28 Becton Dickinson France Pre-filled active vial having integral plunger assembly
US8617123B2 (en) 2009-08-21 2013-12-31 Becton Dickinson France, S.A.S. Pre-filled active vial having integral plunger assembly
US9108047B2 (en) 2010-06-04 2015-08-18 Bayer Medical Care Inc. System and method for planning and monitoring multi-dose radiopharmaceutical usage on radiopharmaceutical injectors
US9463335B2 (en) 2010-06-04 2016-10-11 Bayer Healthcare Llc System and method for planning and monitoring multi-dose radiopharmaceutical usage on radiopharmaceutical injectors
US8979511B2 (en) 2011-05-05 2015-03-17 Eksigent Technologies, Llc Gel coupling diaphragm for electrokinetic delivery systems
US9744305B2 (en) 2012-09-28 2017-08-29 Bayer Healthcare Llc Quick release plunger
US9480797B1 (en) 2015-10-28 2016-11-01 Bayer Healthcare Llc System and method for syringe plunger engagement with an injector

Similar Documents

Publication Publication Date Title
US3502097A (en) Catheter-infuser connector
US3605745A (en) Dental injection apparatus
De la Lande et al. A new and sensitive bioassay for catecholamines
US6840931B2 (en) Osmotic delivery system flow modulator apparatus and method
US5336194A (en) Implantable apparatus
US3731681A (en) Implantable indusion pump
JP2648314B2 (en) Portable apparatus for subcutaneous or intradermal injection
US3342180A (en) Disposable liquid-powder package and hypodermic syringe
US4931050A (en) Constant pressure variable flow pump
US7018360B2 (en) Flow restriction system and method for patient infusion device
US4059109A (en) Mixing and dispensing disposable medicament injector
EP0426319B1 (en) Infusion apparatus
CA1206830A (en) Hypodermic jet injector
US4755172A (en) Syringe holder/driver and syringe arrangement and syringe/holder driver therefor
US6283949B1 (en) Refillable implantable drug delivery pump
CA1297369C (en) Moisture activation of transdermal drug delivery system
US4460370A (en) Trans-dermal medication application cell
US3695266A (en) Needleless sequential dosing syringe
US3886937A (en) Medical administration set for dispensing plural medical liquids
US5869078A (en) Implantable variable permeability drug infusion techniques
EP0458879B1 (en) Intravenous system for delivering a beneficial agent
US4909790A (en) Liquid infusion device
CA1332333C (en) Implantable delivery system for biological factors
US5188603A (en) Fluid infusion delivery system
ES2257262T3 (en) Electrochemical pump, particularly for medication administration.