WO2009041613A1 - 抗体定常領域改変体 - Google Patents
抗体定常領域改変体 Download PDFInfo
- Publication number
- WO2009041613A1 WO2009041613A1 PCT/JP2008/067483 JP2008067483W WO2009041613A1 WO 2009041613 A1 WO2009041613 A1 WO 2009041613A1 JP 2008067483 W JP2008067483 W JP 2008067483W WO 2009041613 A1 WO2009041613 A1 WO 2009041613A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- constant region
- antibody constant
- succeeded
- stability
- finding
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Abstract
Priority Applications (29)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020187033614A KR102119108B1 (ko) | 2007-09-26 | 2008-09-26 | 항체 정상영역 개변체 |
KR1020107008918A KR101680906B1 (ko) | 2007-09-26 | 2008-09-26 | 항체 정상영역 개변체 |
KR1020217006046A KR102339457B1 (ko) | 2007-09-26 | 2008-09-26 | 항체 정상영역 개변체 |
AU2008304748A AU2008304748C1 (en) | 2007-09-26 | 2008-09-26 | Modified antibody constant region |
MX2013009569A MX342551B (es) | 2007-09-26 | 2008-09-26 | Region constante de anticuerpo modificada. |
DK08834649.9T DK2194066T3 (en) | 2007-09-26 | 2008-09-26 | Modified constant region of an antibody |
BRPI0817273-0A BRPI0817273A2 (pt) | 2007-09-26 | 2008-09-26 | Região constante de anticorpo modificada |
KR1020207015247A KR102225009B1 (ko) | 2007-09-26 | 2008-09-26 | 항체 정상영역 개변체 |
EP08834649.9A EP2194066B1 (en) | 2007-09-26 | 2008-09-26 | Modified antibody constant region |
PH12018501459A PH12018501459A1 (en) | 2007-09-26 | 2008-09-26 | Modified antibody constant region |
ES08834649.9T ES2566957T3 (es) | 2007-09-26 | 2008-09-26 | Región constante de anticuerpo modificado |
EP15200628.4A EP3059246B1 (en) | 2007-09-26 | 2008-09-26 | Modified antibody constant region |
JP2009534420A JP5484060B2 (ja) | 2007-09-26 | 2008-09-26 | 抗体定常領域改変体 |
EP18181757.8A EP3415529B1 (en) | 2007-09-26 | 2008-09-26 | Modified antibody constant region |
PL15200628T PL3059246T3 (pl) | 2007-09-26 | 2008-09-26 | Zmodyfikowany region stały przeciwciała |
MX2010003450A MX2010003450A (es) | 2007-09-26 | 2008-09-26 | Region constante de anticuerpo modificada. |
KR1020217040531A KR102467302B1 (ko) | 2007-09-26 | 2008-09-26 | 항체 정상영역 개변체 |
EP20198500.9A EP3789400A1 (en) | 2007-09-26 | 2008-09-26 | Modified antibody constant region |
CN2008801185811A CN101874041B (zh) | 2007-09-26 | 2008-09-26 | 抗体恒定区修饰体 |
CA2700394A CA2700394C (en) | 2007-09-26 | 2008-09-26 | Modified antibody constant region |
US12/680,082 US9688762B2 (en) | 2007-09-26 | 2008-09-26 | Modified antibody constant region |
RU2010116278/10A RU2526512C2 (ru) | 2007-09-26 | 2008-09-26 | Модифицированная константная область антитела |
KR1020167032250A KR101922788B1 (ko) | 2007-09-26 | 2008-09-26 | 항체 정상영역 개변체 |
IL204537A IL204537A0 (en) | 2007-09-26 | 2010-03-16 | Modified antibody constant region |
ZA2010/02422A ZA201002422B (en) | 2007-09-26 | 2010-04-07 | Modified antibody constant region |
HK11100811.4A HK1146728A1 (en) | 2007-09-26 | 2011-01-26 | Modified antibody constant region |
PH12014502106A PH12014502106B1 (en) | 2007-09-26 | 2014-09-22 | Modified antibody constant region |
US15/614,842 US11332533B2 (en) | 2007-09-26 | 2017-06-06 | Modified antibody constant region |
US17/720,937 US20220251225A1 (en) | 2007-09-26 | 2022-04-14 | Modified antibody constant region |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007-250147 | 2007-09-26 | ||
JP2007250147 | 2007-09-26 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/680,082 A-371-Of-International US9688762B2 (en) | 2007-09-26 | 2008-09-26 | Modified antibody constant region |
US15/614,842 Division US11332533B2 (en) | 2007-09-26 | 2017-06-06 | Modified antibody constant region |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2009041613A1 true WO2009041613A1 (ja) | 2009-04-02 |
Family
ID=40511493
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/067483 WO2009041613A1 (ja) | 2007-09-26 | 2008-09-26 | 抗体定常領域改変体 |
Country Status (24)
Country | Link |
---|---|
US (3) | US9688762B2 (ja) |
EP (4) | EP2194066B1 (ja) |
JP (8) | JP5484060B2 (ja) |
KR (6) | KR102225009B1 (ja) |
CN (1) | CN101874041B (ja) |
AR (4) | AR068563A1 (ja) |
AU (1) | AU2008304748C1 (ja) |
BR (1) | BRPI0817273A2 (ja) |
CA (5) | CA3139492A1 (ja) |
CL (1) | CL2008002886A1 (ja) |
DK (2) | DK2194066T3 (ja) |
ES (2) | ES2687808T3 (ja) |
HK (1) | HK1146728A1 (ja) |
IL (1) | IL204537A0 (ja) |
MX (2) | MX2010003450A (ja) |
MY (3) | MY180713A (ja) |
PE (1) | PE20090711A1 (ja) |
PH (2) | PH12018501459A1 (ja) |
PL (1) | PL3059246T3 (ja) |
RU (2) | RU2526512C2 (ja) |
SG (2) | SG10201605394SA (ja) |
TW (2) | TWI563002B (ja) |
WO (1) | WO2009041613A1 (ja) |
ZA (1) | ZA201002422B (ja) |
Cited By (93)
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WO2010064697A1 (ja) * | 2008-12-05 | 2010-06-10 | 中外製薬株式会社 | 抗nr10抗体、およびその利用 |
WO2010107110A1 (ja) * | 2009-03-19 | 2010-09-23 | 中外製薬株式会社 | 抗体定常領域改変体 |
WO2010106812A1 (en) * | 2009-03-19 | 2010-09-23 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical formulation containing improved antibody molecules |
WO2010107108A1 (ja) * | 2009-03-19 | 2010-09-23 | 中外製薬株式会社 | 関節リウマチ治療剤 |
WO2010107109A1 (ja) * | 2009-03-19 | 2010-09-23 | 中外製薬株式会社 | 抗体定常領域改変体 |
WO2010131733A1 (ja) | 2009-05-15 | 2010-11-18 | 中外製薬株式会社 | 抗axl抗体 |
WO2011037158A1 (ja) | 2009-09-24 | 2011-03-31 | 中外製薬株式会社 | 抗体定常領域改変体 |
WO2011055550A1 (ja) | 2009-11-05 | 2011-05-12 | 国立大学法人大阪大学 | 自己免疫疾患又はアレルギー治療剤とそのスクリーニング方法 |
WO2011090088A1 (ja) | 2010-01-20 | 2011-07-28 | 中外製薬株式会社 | 安定化抗体含有溶液製剤 |
WO2011092989A1 (ja) | 2010-01-29 | 2011-08-04 | 東レ株式会社 | ポリ乳酸系樹脂シート |
JPWO2010064697A1 (ja) * | 2008-12-05 | 2012-05-10 | 中外製薬株式会社 | 抗nr10抗体、およびその利用 |
WO2012067176A1 (ja) | 2010-11-17 | 2012-05-24 | 中外製薬株式会社 | 血液凝固第viii因子の機能を代替する機能を有する多重特異性抗原結合分子 |
WO2012073985A1 (ja) * | 2010-11-30 | 2012-06-07 | 中外製薬株式会社 | 細胞傷害誘導治療剤 |
WO2012115241A1 (ja) | 2011-02-25 | 2012-08-30 | 中外製薬株式会社 | FcγRIIb特異的Fc抗体 |
WO2013002362A1 (ja) | 2011-06-30 | 2013-01-03 | 中外製薬株式会社 | ヘテロ二量化ポリペプチド |
WO2013012022A1 (ja) | 2011-07-19 | 2013-01-24 | 中外製薬株式会社 | アルギニンアミドまたはその類似化合物を含む安定なタンパク質含有製剤 |
US8431127B2 (en) | 2007-12-05 | 2013-04-30 | Chugai Seiyaku Kabushiki Kaisha | Method for treating pruritus comprising administering an NR10 antagonist |
JPWO2011108714A1 (ja) * | 2010-03-04 | 2013-06-27 | 中外製薬株式会社 | 抗体定常領域改変体 |
WO2013100120A1 (ja) | 2011-12-28 | 2013-07-04 | 中外製薬株式会社 | ヒト化抗Epiregulin抗体および当該抗体を有効成分として含む癌治療剤 |
WO2013118858A1 (ja) | 2012-02-09 | 2013-08-15 | 中外製薬株式会社 | 抗体のFc領域改変体 |
US8562991B2 (en) | 2008-09-26 | 2013-10-22 | Chugai Seiyaku Kabushiki Kaisha | Antibody molecules that bind to IL-6 receptor |
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WO2013187495A1 (ja) | 2012-06-14 | 2013-12-19 | 中外製薬株式会社 | 改変されたFc領域を含む抗原結合分子 |
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