WO2001090121A2 - Methods and compositions for treating hepatitis c virus - Google Patents

Methods and compositions for treating hepatitis c virus Download PDF

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Publication number
WO2001090121A2
WO2001090121A2 PCT/US2001/016671 US0116671W WO0190121A2 WO 2001090121 A2 WO2001090121 A2 WO 2001090121A2 US 0116671 W US0116671 W US 0116671W WO 0190121 A2 WO0190121 A2 WO 0190121A2
Authority
WO
WIPO (PCT)
Prior art keywords
alkyl
acyl
lower alkyl
compound
pharmaceutically acceptable
Prior art date
Application number
PCT/US2001/016671
Other languages
English (en)
French (fr)
Other versions
WO2001090121A3 (en
Inventor
Jean-Pierre Sommadossi
Paulo Lacolla
Original Assignee
Idenix (Cayman) Limited
Universita Degli Studi Di Cagliari
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22767031&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2001090121(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to MXPA02011635A priority Critical patent/MXPA02011635A/es
Priority to IL15293401A priority patent/IL152934A0/xx
Priority to APAP/P/2002/002704A priority patent/AP1782A/en
Priority to ES01941564.5T priority patent/ES2620807T3/es
Priority to PL389775A priority patent/PL227118B1/pl
Priority to AP2006003817A priority patent/AP2006003817A0/xx
Priority to EP01941564.5A priority patent/EP1292603B8/en
Priority to AU7490601A priority patent/AU7490601A/xx
Priority to EA200201279A priority patent/EA007178B1/ru
Priority to JP2001586308A priority patent/JP2004533401A/ja
Priority to YU92102A priority patent/RS52394B/en
Priority to PL366159A priority patent/PL220775B1/pl
Priority to NZ522863A priority patent/NZ522863A/en
Priority to BR0111127-2A priority patent/BR0111127A/pt
Application filed by Idenix (Cayman) Limited, Universita Degli Studi Di Cagliari filed Critical Idenix (Cayman) Limited
Priority to CA2409613A priority patent/CA2409613C/en
Priority to AU2001274906A priority patent/AU2001274906B2/en
Publication of WO2001090121A2 publication Critical patent/WO2001090121A2/en
Publication of WO2001090121A3 publication Critical patent/WO2001090121A3/en
Priority to IL152934A priority patent/IL152934A/en
Priority to NO20025627A priority patent/NO325352B1/no
Priority to AU2006203121A priority patent/AU2006203121B2/en
Priority to AU2006203122A priority patent/AU2006203122B2/en
Priority to NO20073151A priority patent/NO332750B1/no
Priority to IL196301A priority patent/IL196301A0/en
Priority to NO20121027A priority patent/NO20121027A1/no
Priority to NO20121146A priority patent/NO20121146L/no

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03C—PHOTOSENSITIVE MATERIALS FOR PHOTOGRAPHIC PURPOSES; PHOTOGRAPHIC PROCESSES, e.g. CINE, X-RAY, COLOUR, STEREO-PHOTOGRAPHIC PROCESSES; AUXILIARY PROCESSES IN PHOTOGRAPHY
    • G03C1/00—Photosensitive materials
    • G03C1/005—Silver halide emulsions; Preparation thereof; Physical treatment thereof; Incorporation of additives therein
    • G03C1/0051—Tabular grain emulsions
PCT/US2001/016671 2000-05-23 2001-05-23 Methods and compositions for treating hepatitis c virus WO2001090121A2 (en)

Priority Applications (24)

Application Number Priority Date Filing Date Title
IL15293401A IL152934A0 (en) 2000-05-23 2001-05-23 Methods and compositions for treating hepatitis c virus
BR0111127-2A BR0111127A (pt) 2000-05-23 2001-05-23 Métodos e composições para tratamento do vìrus de hepatite c
NZ522863A NZ522863A (en) 2000-05-23 2001-05-23 2' branched nucleosides in methods and compositions for the treatment of hepatitis C
ES01941564.5T ES2620807T3 (es) 2000-05-23 2001-05-23 Métodos y composiciones para tratar el virus de la hepatitis C
PL389775A PL227118B1 (pl) 2000-05-23 2001-05-23 Zwiazek nukleozydowy lub jego farmaceutycznie dopuszczalna sól dozastosowania wleczeniu lub prolaktyce zakazenia wirusem zapalenia watroby typu C
AP2006003817A AP2006003817A0 (en) 2000-05-23 2001-05-23 methods and compositions for treating hepatitis C virus
EP01941564.5A EP1292603B8 (en) 2000-05-23 2001-05-23 Methods and compositions for treating hepatitis c virus
AU7490601A AU7490601A (en) 2000-05-23 2001-05-23 Methods and compositions for treating hepatitis c virus
EA200201279A EA007178B1 (ru) 2000-05-23 2001-05-23 Производные beta-d-нуклеозида в качестве лекарственного средства для лечения инфекции вируса гепатита c у хозяина
JP2001586308A JP2004533401A (ja) 2000-05-23 2001-05-23 Ｃ型肝炎ウイルス治療のための方法および組成物
YU92102A RS52394B (en) 2000-05-23 2001-05-23 METHODS AND MIXTURES FOR TREATMENT OF VIRAL HEPATITIS C
PL366159A PL220775B1 (pl) 2000-05-23 2001-05-23 Kompozycja farmaceutyczna do stosowania w leczeniu wirusowego zapalenia wątroby typu C i zastosowanie związków o określonej strukturze do wytwarzania leku do leczenia wirusowego zapalenia wątroby typu C
APAP/P/2002/002704A AP1782A (en) 2000-05-23 2001-05-23 Use of compounds ?-D or ?-L nucleoside for treating hepatitis C virus.
MXPA02011635A MXPA02011635A (es) 2000-05-23 2001-05-23 Metodos y composiciones para el tratamiento del virus de la hepatitis c.
AU2001274906A AU2001274906B2 (en) 2000-05-23 2001-05-23 Methods and compositions for treating Hepatitis C virus
CA2409613A CA2409613C (en) 2000-05-23 2001-05-23 Methods and compositions for treating hepatitis c virus
IL152934A IL152934A (en) 2000-05-23 2002-11-19 Use of a nucleoside in the manufacture of a medicament for treating heapatitis c virus
NO20025627A NO325352B1 (no) 2000-05-23 2002-11-22 Anvendelse av nukleosider for fremstilling av medikamenter
AU2006203121A AU2006203121B2 (en) 2000-05-23 2006-07-21 Methods and compositions for treating Hepatitis C virus
AU2006203122A AU2006203122B2 (en) 2000-05-23 2006-07-21 Methods and compositions for treating Hepatitis C virus
NO20073151A NO332750B1 (no) 2000-05-23 2007-06-20 Anvendelse av nukleosider for fremstilling av et medikament for behandling av hepatitt C virus
IL196301A IL196301A0 (en) 2000-05-23 2008-12-31 Medicament for the treatment of hapatitis c
NO20121027A NO20121027A1 (no) 2001-05-23 2012-09-12 Fremgangsmater og sammensetninger for a behandle hepatitt C-virus
NO20121146A NO20121146L (no) 2000-05-23 2012-10-10 Fremgangsmåter og sammensetninger for å behandle hepatitt C virus

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20658500P 2000-05-23 2000-05-23
US60/206,585 2000-05-23

Publications (2)

Publication Number Publication Date
WO2001090121A2 true WO2001090121A2 (en) 2001-11-29
WO2001090121A3 WO2001090121A3 (en) 2002-05-02

Family

ID=22767031

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/016671 WO2001090121A2 (en) 2000-05-23 2001-05-23 Methods and compositions for treating hepatitis c virus

Country Status (27)

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US (10) US6914054B2 (US20040097461A1-20040520-C00035.png)
EP (3) EP1669364A3 (US20040097461A1-20040520-C00035.png)
JP (6) JP2004533401A (US20040097461A1-20040520-C00035.png)
KR (3) KR20070036806A (US20040097461A1-20040520-C00035.png)
CN (3) CN101367856A (US20040097461A1-20040520-C00035.png)
AP (2) AP1782A (US20040097461A1-20040520-C00035.png)
AR (1) AR035336A1 (US20040097461A1-20040520-C00035.png)
AU (5) AU7490601A (US20040097461A1-20040520-C00035.png)
BR (1) BR0111127A (US20040097461A1-20040520-C00035.png)
CA (3) CA2409613C (US20040097461A1-20040520-C00035.png)
CZ (1) CZ301169B6 (US20040097461A1-20040520-C00035.png)
EA (2) EA011720B1 (US20040097461A1-20040520-C00035.png)
ES (2) ES2531011T3 (US20040097461A1-20040520-C00035.png)
IL (3) IL152934A0 (US20040097461A1-20040520-C00035.png)
MA (1) MA27292A1 (US20040097461A1-20040520-C00035.png)
MX (1) MXPA02011635A (US20040097461A1-20040520-C00035.png)
MY (1) MY164523A (US20040097461A1-20040520-C00035.png)
NO (3) NO325352B1 (US20040097461A1-20040520-C00035.png)
NZ (2) NZ522863A (US20040097461A1-20040520-C00035.png)
PE (2) PE20100363A1 (US20040097461A1-20040520-C00035.png)
PL (3) PL227118B1 (US20040097461A1-20040520-C00035.png)
RS (2) RS53722B1 (US20040097461A1-20040520-C00035.png)
SG (5) SG189556A1 (US20040097461A1-20040520-C00035.png)
TW (4) TW200730537A (US20040097461A1-20040520-C00035.png)
UY (2) UY26724A1 (US20040097461A1-20040520-C00035.png)
WO (1) WO2001090121A2 (US20040097461A1-20040520-C00035.png)
ZA (2) ZA200210101B (US20040097461A1-20040520-C00035.png)

Cited By (259)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002018404A2 (en) * 2000-08-30 2002-03-07 F. Hoffmann-La Roche Ag Nucleoside derivatives for the treatment of hepatitis c
WO2001092282A3 (en) * 2000-05-26 2002-05-02 Novirio Pharmaceuticals Ltd Methods and compositions for treating flaviviruses and pestiviruses
WO2003000713A1 (en) * 2001-06-21 2003-01-03 Glaxo Group Limited Nucleoside compounds in hcv
WO2003051898A1 (en) * 2001-12-17 2003-06-26 Ribapharm Inc. Unusual nucleoside libraries, compounds, and preferred uses as antiviral and anticancer agents
WO2003062256A1 (en) * 2002-01-17 2003-07-31 Ribapharm Inc. 2'-beta-modified-6-substituted adenosine analogs and their use as antiviral agents
WO2003062255A2 (en) * 2002-01-17 2003-07-31 Ribapharm Inc. Sugar modified nucleosides as viral replication inhibitors
WO2003068244A1 (en) * 2002-02-13 2003-08-21 Merck & Co., Inc. Methods of inhibiting orthopoxvirus replication with nucleoside compounds
WO2003093290A2 (en) * 2002-05-06 2003-11-13 Genelabs Technologies, Inc. Nucleoside derivatives for treating hepatitis c virus infection
WO2004003000A2 (en) 2002-06-28 2004-01-08 Idenix (Cayman) Limited 1’-, 2'- and 3'- modified nucleoside derivatives for treating flaviviridae infections
WO2004046331A2 (en) 2002-11-15 2004-06-03 Idenix (Cayman) Limited 2’-branched nucleosides and flaviviridae mutation
WO2004002999A3 (en) * 2002-06-28 2004-08-12 Idenix Cayman Ltd Modified 2' and 3' -nucleoside produgs for treating flaviridae infections
US6777395B2 (en) 2001-01-22 2004-08-17 Merck & Co., Inc. Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase of hepatitis C virus
WO2005003147A2 (en) 2003-05-30 2005-01-13 Pharmasset, Inc. Modified fluorinated nucleoside analogues
US6846810B2 (en) 2002-11-19 2005-01-25 Roche Palo Alto Llc Antiviral nucleoside derivatives
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