KR20210158864A - 치료제 운반용 신규 지질 및 조성물 - Google Patents

치료제 운반용 신규 지질 및 조성물 Download PDF

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KR20210158864A
KR20210158864A KR1020217041960A KR20217041960A KR20210158864A KR 20210158864 A KR20210158864 A KR 20210158864A KR 1020217041960 A KR1020217041960 A KR 1020217041960A KR 20217041960 A KR20217041960 A KR 20217041960A KR 20210158864 A KR20210158864 A KR 20210158864A
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gene
lipid
optionally substituted
nucleic acid
peg
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무티아 마노하란
무투사미 자야라만
칼란토따틸 쥐. 라지브
락스만 엘테푸
스티븐 안셀
지안신 첸
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알닐람 파마슈티칼스 인코포레이티드
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Priority to KR1020227033566A priority Critical patent/KR20220138415A/ko
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    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/46—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
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CA2569664C (en) 2004-06-07 2013-07-16 Protiva Biotherapeutics, Inc. Lipid encapsulated interfering rna
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US8546554B2 (en) 2008-09-25 2013-10-01 Alnylam Pharmaceuticals, Inc. Lipid formulated compositions and methods for inhibiting expression of Serum Amyloid A gene
AU2009303345B2 (en) 2008-10-09 2015-08-20 Arbutus Biopharma Corporation Improved amino lipids and methods for the delivery of nucleic acids
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