ES2531751T3 - Montaje de microvesícula rellena de gas con componente activo para imagenología de contraste - Google Patents

Montaje de microvesícula rellena de gas con componente activo para imagenología de contraste Download PDF

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Publication number
ES2531751T3
ES2531751T3 ES04806412.5T ES04806412T ES2531751T3 ES 2531751 T3 ES2531751 T3 ES 2531751T3 ES 04806412 T ES04806412 T ES 04806412T ES 2531751 T3 ES2531751 T3 ES 2531751T3
Authority
ES
Spain
Prior art keywords
assembly
gas filled
active component
contrast imaging
filled microvesicle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES04806412.5T
Other languages
English (en)
Inventor
Michel Schneider
Philippe Bussat
Feng Yan
Anne Senente
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco Suisse SA
Original Assignee
Bracco Suisse SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Suisse SA filed Critical Bracco Suisse SA
Application granted granted Critical
Publication of ES2531751T3 publication Critical patent/ES2531751T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6925—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a microcapsule, nanocapsule, microbubble or nanobubble
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/225—Microparticles, microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nanotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

Un montaje que comprende una microvesícula rellena de gas que tiene una primera carga neta global y un componente asociado a dicha microvesícula en donde dicho componente es una estructura supramolecular formada por la asociación de una pluralidad de moléculas, tiene una segunda carga neta global opuesta en signo a dicha primera carga neta y comprende un ligando de direccionamiento, un agente diagnóstico o cualquier combinación de los mismos, y un agente tensioactivo anfifílico biocompatible.
ES04806412.5T 2003-12-22 2004-12-21 Montaje de microvesícula rellena de gas con componente activo para imagenología de contraste Expired - Lifetime ES2531751T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03079014 2003-12-22
EP03079014 2003-12-22
PCT/IB2004/004233 WO2005063306A1 (en) 2003-12-22 2004-12-21 Assembly of gas-filled microvesicle with active component for contrast imaging

Publications (1)

Publication Number Publication Date
ES2531751T3 true ES2531751T3 (es) 2015-03-18

Family

ID=34717205

Family Applications (1)

Application Number Title Priority Date Filing Date
ES04806412.5T Expired - Lifetime ES2531751T3 (es) 2003-12-22 2004-12-21 Montaje de microvesícula rellena de gas con componente activo para imagenología de contraste

Country Status (9)

Country Link
US (2) US20070081946A1 (es)
EP (1) EP1696965B1 (es)
JP (1) JP2007515471A (es)
CN (1) CN1897978B (es)
AU (1) AU2004308757B2 (es)
CA (1) CA2545362C (es)
ES (1) ES2531751T3 (es)
NO (1) NO338317B1 (es)
WO (1) WO2005063306A1 (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1590006T3 (da) 2003-02-04 2010-12-20 Bracco Suisse Sa Ultralydskontrastmidler og fremgangsmåde til frembringelse deraf
WO2005063305A1 (en) 2003-12-22 2005-07-14 Bracco Research Sa Gas-filled microvesicle assembly for contrast imaging
US20070003482A1 (en) * 2004-01-15 2007-01-04 Koninklijke Philips Electronic, N.V. Ultrasound contrast agents for molecular imaging
US9248204B2 (en) 2004-08-18 2016-02-02 Bracco Suisse S.A. Gas-filled microvesicles composition for contrast imaging
WO2007076295A2 (en) * 2005-12-16 2007-07-05 University Of Kansas Nanoclusters for delivery of therapeutics
JP5420410B2 (ja) 2006-09-05 2014-02-19 ブラッコ・シュイス・ソシエテ・アノニム ポリマー修飾脂質を含むガス封入微小胞
US20100041989A1 (en) * 2006-09-29 2010-02-18 The Trustees Of The University Of Pennsylvania Use of ultrasound as an antivascular agent
US20090234231A1 (en) * 2008-03-13 2009-09-17 Knight Jon M Imaging Catheter With Integrated Contrast Agent Injector
GB0811856D0 (en) 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
WO2010040772A2 (en) * 2008-10-07 2010-04-15 Bracco Research Sa Targeting construct comprising anti-polymer antibody and liposomes or microvesicles binding to the same
DK2355851T3 (en) 2008-11-10 2018-06-25 Arbutus Biopharma Corp Newly known lipids and compositions for release of therapeutic agents
CN106362171A (zh) 2009-02-13 2017-02-01 华盛顿大学 用于磁共振成像的钆表现脂质纳米颗粒
EP2253308A1 (en) 2009-05-22 2010-11-24 Ludwig-Maximilians-Universität München Pharmaceutical composition comprising microbubbles for targeted tumor therapy
WO2011017524A1 (en) * 2009-08-05 2011-02-10 The Trustees Of The University Of Pennsylvania Microfluidic-based generation of functionalized microbubbles for ultrasound imaging and therapy
WO2011025893A1 (en) 2009-08-28 2011-03-03 The Trustees Of Columbia University In The City Of New York Systems, methods, and devices for production of gas-filled microbubbles
WO2011035254A1 (en) * 2009-09-21 2011-03-24 Drexel University Stabilized ultrasound contrast agent
WO2011091160A1 (en) * 2010-01-20 2011-07-28 Henry Wu Custom-formulated phospholipid microbubbles and methods and uses thereof
EP2600771A1 (en) 2010-08-06 2013-06-12 The Trustees of Columbia University in the City of New York Medical imaging contrast devices, methods, and systems
TW201208706A (en) 2010-08-17 2012-03-01 Univ Nat Yang Ming Ultrasonically-triggered drug vehicle with magnetic resonance imaging function
KR101292939B1 (ko) * 2010-12-31 2013-08-02 삼성전자주식회사 엠알유도 고강도집속초음파 치료 및 진단용 인지질 나노입자 및 이의 제조방법
EP2934740B1 (en) 2012-12-21 2019-12-11 Bracco Suisse SA Gas-filled microvesicles
JP6876436B2 (ja) * 2013-09-27 2021-05-26 イグザクト・セラピューティクス・アーエス 超音波により媒介される薬物送達
JP6202563B2 (ja) * 2013-10-21 2017-09-27 ネッパジーン株式会社 負電荷バブルリポソーム及びカチオン性ペプチドからなる薬物送達キャリア
KR101595795B1 (ko) * 2014-03-19 2016-02-22 (주)아이엠지티 약물을 함유한 나노입자가 결합된 이중-목적 paｔ／초음파 조영제 및 이의 제조방법
CN111836650B (zh) * 2018-03-07 2024-06-18 博莱科瑞士股份有限公司 尺寸可控微泡的制备
CN113573803B (zh) * 2018-12-21 2024-05-28 博莱科瑞士股份有限公司 含有配体的充气微泡
GB2595513B (en) * 2020-05-29 2023-03-29 Act Therapeutics Ltd Treatment of infections
CN117479962A (zh) * 2021-07-14 2024-01-30 博莱科瑞士股份有限公司 阳离子标准化尺寸充气微泡
WO2024059715A2 (en) * 2022-09-14 2024-03-21 Drexel University Microbubbles and methods of making same
NO20221187A1 (en) 2022-11-04 2024-05-06 Exact Therapeutics As Method and system for calculating a point estimate of an ultrasound dose

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4276885A (en) * 1979-05-04 1981-07-07 Rasor Associates, Inc Ultrasonic image enhancement
DE3581471D1 (de) * 1984-10-19 1991-02-28 Battelle Memorial Institute Durch mikroorganismen abbaubares polypeptid und seine verwendung fuer die fortschreitende abgabe von medikamenten.
US5556610A (en) * 1992-01-24 1996-09-17 Bracco Research S.A. Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method
US5445813A (en) * 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
IN172208B (es) * 1990-04-02 1993-05-01 Sint Sa
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
US5562099A (en) * 1990-10-05 1996-10-08 Massachusetts Institute Of Technology Polymeric microparticles containing agents for imaging
IL104084A (en) * 1992-01-24 1996-09-12 Bracco Int Bv Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them
US5464696A (en) * 1992-08-13 1995-11-07 Bracco International B.V. Particles for NMR imaging
EP1550464A1 (en) * 1993-07-30 2005-07-06 IMCOR Pharmaceutical Co. Stabilized microbubble composition for ultrasound
NO940711D0 (no) * 1994-03-01 1994-03-01 Nycomed Imaging As Preparation of gas-filled microcapsules and contrasts agents for diagnostic imaging
US6333021B1 (en) * 1994-11-22 2001-12-25 Bracco Research S.A. Microcapsules, method of making and their use
IL116328A (en) * 1994-12-16 1999-09-22 Bracco Research Sa Frozen suspension of gas microbubbles in frozen aqueous carrier for use as contrast agent in ultrasonic imaging
US6139819A (en) * 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
ES2197986T3 (es) * 1996-02-19 2004-01-16 Amersham Health As Mejoras introducidas en o relacionadas con agentes de contraste.
US6264917B1 (en) * 1996-10-28 2001-07-24 Nycomed Imaging As Targeted ultrasound contrast agents
IL129445A0 (en) * 1996-10-28 2000-02-29 Nycomed Imaging As Improvements in or relating to diagnostic/therapeutic agents
US6331289B1 (en) * 1996-10-28 2001-12-18 Nycomed Imaging As Targeted diagnostic/therapeutic agents having more than one different vectors
US6416740B1 (en) * 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
CA2319433C (en) * 1998-02-09 2008-04-22 Bracco Suisse S.A. Targeted delivery of biologically active media
GB9808599D0 (en) * 1998-04-22 1998-06-24 Nycomed Imaging As Improvements in or realting to contrast agents
JP2002212108A (ja) * 2001-01-17 2002-07-31 Fuji Photo Film Co Ltd 超音波散乱体
CA2456988A1 (en) * 2001-08-16 2003-02-27 Alan P. Carpenter, Jr. Gas microsphere liposome composites
WO2005063305A1 (en) * 2003-12-22 2005-07-14 Bracco Research Sa Gas-filled microvesicle assembly for contrast imaging

Also Published As

Publication number Publication date
NO20063420L (no) 2006-09-22
CN1897978A (zh) 2007-01-17
EP1696965B1 (en) 2014-12-10
CA2545362A1 (en) 2005-07-14
AU2004308757A1 (en) 2005-07-14
AU2004308757B2 (en) 2010-06-17
NO338317B1 (no) 2016-08-08
CA2545362C (en) 2013-02-12
EP1696965A1 (en) 2006-09-06
US20070081946A1 (en) 2007-04-12
CN1897978B (zh) 2011-11-23
JP2007515471A (ja) 2007-06-14
US20110150778A1 (en) 2011-06-23
WO2005063306A1 (en) 2005-07-14

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