JP6539667B2 - Ｔｉｍ−３に対する抗体分子およびその使用 - Google Patents

Ｔｉｍ−３に対する抗体分子およびその使用 Download PDF

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Publication number
JP6539667B2
JP6539667B2 JP2016549254A JP2016549254A JP6539667B2 JP 6539667 B2 JP6539667 B2 JP 6539667B2 JP 2016549254 A JP2016549254 A JP 2016549254A JP 2016549254 A JP2016549254 A JP 2016549254A JP 6539667 B2 JP6539667 B2 JP 6539667B2
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seq
amino acid
acid sequence
antibody molecule
tim
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JP2017511687A (ja
JP2017511687A5 (OSRAM
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キャサリン・アン・サバトス−ペイトン
バルバラ・ブランネッティ
アラン・エス・ハリス
トーマス・フーバー
トーマス・ピーツォンカ
ジェニファー・マリー・マタラザ
ウォルター・エイ・ブラットラー
ダニエル・ジェイ・ヒックリン
マキシミリアノ・バスケス
ローズマリー・エイチ・デクルイフ
デイル・ティー・ウメツ
ゴードン・ジェイムズ・フリーマン
ティアンセン・フー
ジョン・エイ・タラシュカ
ファンミン・シュー
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Boston Childrens Hospital
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Boston Childrens Hospital
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • G—PHYSICS
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • G—PHYSICS
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    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
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  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
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  • Communicable Diseases (AREA)
JP2016549254A 2014-01-31 2015-01-30 Ｔｉｍ−３に対する抗体分子およびその使用 Active JP6539667B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461934469P 2014-01-31 2014-01-31
US61/934,469 2014-01-31
US201462094912P 2014-12-19 2014-12-19
US62/094,912 2014-12-19
PCT/US2015/013913 WO2015117002A1 (en) 2014-01-31 2015-01-30 Antibody molecules to tim-3 and uses thereof

Related Child Applications (1)

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JP2019076078A Division JP6856694B2 (ja) 2014-01-31 2019-04-12 Ｔｉｍ−３に対する抗体分子およびその使用

Publications (3)

Publication Number Publication Date
JP2017511687A JP2017511687A (ja) 2017-04-27
JP2017511687A5 JP2017511687A5 (OSRAM) 2018-03-08
JP6539667B2 true JP6539667B2 (ja) 2019-07-03

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JP2016549254A Active JP6539667B2 (ja) 2014-01-31 2015-01-30 Ｔｉｍ−３に対する抗体分子およびその使用
JP2019076078A Active JP6856694B2 (ja) 2014-01-31 2019-04-12 Ｔｉｍ−３に対する抗体分子およびその使用
JP2021044910A Pending JP2021104025A (ja) 2014-01-31 2021-03-18 Ｔｉｍ−３に対する抗体分子およびその使用

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JP2021044910A Pending JP2021104025A (ja) 2014-01-31 2021-03-18 Ｔｉｍ−３に対する抗体分子およびその使用

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US (6) US9605070B2 (OSRAM)
EP (3) EP3099717B1 (OSRAM)
JP (3) JP6539667B2 (OSRAM)
KR (2) KR20220028145A (OSRAM)
CN (2) CN113896791A (OSRAM)
AU (2) AU2015210750B2 (OSRAM)
CA (1) CA2936863A1 (OSRAM)
CL (1) CL2016001716A1 (OSRAM)
CR (1) CR20160347A (OSRAM)
CU (1) CU24427B1 (OSRAM)
CY (1) CY1121893T1 (OSRAM)
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EA (1) EA201691556A1 (OSRAM)
EC (1) ECSP16070447A (OSRAM)
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IL (1) IL246693B2 (OSRAM)
JO (2) JOP20200096A1 (OSRAM)
LT (1) LT3099717T (OSRAM)
ME (1) ME03489B (OSRAM)
MX (2) MX375953B (OSRAM)
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NZ (2) NZ761188A (OSRAM)
PE (1) PE20170330A1 (OSRAM)
PH (1) PH12016501482B1 (OSRAM)
PL (1) PL3099717T3 (OSRAM)
PT (1) PT3099717T (OSRAM)
RS (1) RS59065B1 (OSRAM)
SG (1) SG11201605627TA (OSRAM)
SI (1) SI3099717T1 (OSRAM)
TW (2) TWI686406B (OSRAM)
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US8709412B2 (en) * 2001-06-29 2014-04-29 The Board Of Trustees Of The Leland Stanford Junior University Modulation of TIM receptor activity in combination with cytoreductive therapy
MX349137B (es) * 2005-06-08 2017-07-13 Dana-Farber Cancer Inst Metodos y composiciones para el tratamiento de infecciones persistentes y cancer por inhibicion de la ruta de muerte celular programada (pd-1).
WO2010106051A1 (en) * 2009-03-17 2010-09-23 Universite De La Mediterranee Btla antibodies and uses thereof
EP2686347B1 (en) 2011-03-16 2018-05-02 argenx BVBA Antibodies to cd70
PT3409278T (pt) 2011-07-21 2020-12-18 Sumitomo Dainippon Pharma Oncology Inc Inibidores de proteína cinase heterocíclicos
EP3049442A4 (en) 2013-09-26 2017-06-28 Costim Pharmaceuticals Inc. Methods for treating hematologic cancers
JOP20200094A1 (ar) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc جزيئات جسم مضاد لـ pd-1 واستخداماتها
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