JP2009503113A5 - - Google Patents
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- JP2009503113A5 JP2009503113A5 JP2008525241A JP2008525241A JP2009503113A5 JP 2009503113 A5 JP2009503113 A5 JP 2009503113A5 JP 2008525241 A JP2008525241 A JP 2008525241A JP 2008525241 A JP2008525241 A JP 2008525241A JP 2009503113 A5 JP2009503113 A5 JP 2009503113A5
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- JP
- Japan
- Prior art keywords
- optionally substituted
- phenyl
- solubilizing group
- compound
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- Prior art date
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- -1 2,4-dimethoxyphenyl Chemical group 0.000 claims 38
- 150000001875 compounds Chemical class 0.000 claims 29
- 230000003381 solubilizing effect Effects 0.000 claims 23
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 20
- 125000000217 alkyl group Chemical group 0.000 claims 18
- 229910052760 oxygen Inorganic materials 0.000 claims 15
- 229910052717 sulfur Inorganic materials 0.000 claims 10
- 239000000203 mixture Substances 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 7
- 125000002950 monocyclic group Chemical group 0.000 claims 5
- CAAZTHGLVRBFET-UHFFFAOYSA-N 2-chloro-n-[3-[3-(cyclohexylamino)imidazo[1,2-a]pyridin-2-yl]phenyl]-4-nitrobenzamide Chemical compound ClC1=CC([N+](=O)[O-])=CC=C1C(=O)NC1=CC=CC(C2=C(N3C=CC=CC3=N2)NC2CCCCC2)=C1 CAAZTHGLVRBFET-UHFFFAOYSA-N 0.000 claims 3
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 239000000651 prodrug Substances 0.000 claims 3
- 229940002612 prodrug Drugs 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims 2
- 125000003762 3,4-dimethoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 claims 2
- 206010022489 Insulin Resistance Diseases 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 125000002541 furyl group Chemical group 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000005809 3,4,5-trimethoxyphenyl group Chemical group [H]C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 claims 1
- 125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 claims 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000004860 4-ethylphenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 239000004305 biphenyl Substances 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000000040 m-tolyl group Chemical group [H]C1=C([H])C(*)=C([H])C(=C1[H])C([H])([H])[H] 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 1
- 125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 claims 1
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 239000002510 pyrogen Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
- 0 **c1cc(-c2c[n](cccc3)c3n2)ccc1 Chemical compound **c1cc(-c2c[n](cccc3)c3n2)ccc1 0.000 description 3
- OBSLLHNATPQFMJ-UHFFFAOYSA-N Cc1c[s]c(C)n1 Chemical compound Cc1c[s]c(C)n1 OBSLLHNATPQFMJ-UHFFFAOYSA-N 0.000 description 1
- VYKJIMCPOLQFJR-UHFFFAOYSA-N Clc(cccc1)c1-c1n[o]c(I)c1 Chemical compound Clc(cccc1)c1-c1n[o]c(I)c1 VYKJIMCPOLQFJR-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70561205P | 2005-08-04 | 2005-08-04 | |
| US60/705,612 | 2005-08-04 | ||
| US74178305P | 2005-12-02 | 2005-12-02 | |
| US60/741,783 | 2005-12-02 | ||
| US77937006P | 2006-03-03 | 2006-03-03 | |
| US60/779,370 | 2006-03-03 | ||
| US79227606P | 2006-04-14 | 2006-04-14 | |
| US60/792,276 | 2006-04-14 | ||
| PCT/US2006/030511 WO2007019345A1 (en) | 2005-08-04 | 2006-08-04 | Imidazopyridine derivatives as sirtuin modulating agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009503113A JP2009503113A (ja) | 2009-01-29 |
| JP2009503113A5 true JP2009503113A5 (enExample) | 2009-09-17 |
| JP5203194B2 JP5203194B2 (ja) | 2013-06-05 |
Family
ID=37074951
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008525272A Pending JP2009503117A (ja) | 2005-08-04 | 2006-08-04 | サーチュインモジュレーターとしてのベンゾイミダゾール誘導体 |
| JP2008525240A Expired - Fee Related JP5203193B2 (ja) | 2005-08-04 | 2006-08-04 | サーチュイン調節化合物としてのイミダゾ［２，１−ｂ］チアゾール誘導体 |
| JP2008525242A Expired - Fee Related JP5203195B2 (ja) | 2005-08-04 | 2006-08-04 | サーチュインモジュレーターとしてのベンゾチアゾールおよびチアゾロピリジン |
| JP2008525241A Expired - Fee Related JP5203194B2 (ja) | 2005-08-04 | 2006-08-04 | サーチュイン調節因子としてのイミダゾピリジン誘導体 |
| JP2008525273A Expired - Fee Related JP5203196B2 (ja) | 2005-08-04 | 2006-08-04 | サーチュインモジュレーターとしてのオキサゾロピリジン誘導体 |
| JP2012126044A Withdrawn JP2012211149A (ja) | 2005-08-04 | 2012-06-01 | サーチュインモジュレーターとしてのベンゾチアゾールおよびチアゾロピリジン |
| JP2012125926A Withdrawn JP2012214480A (ja) | 2005-08-04 | 2012-06-01 | サーチュイン調節化合物としてのイミダゾ［２，１−ｂ］チアゾール誘導体 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008525272A Pending JP2009503117A (ja) | 2005-08-04 | 2006-08-04 | サーチュインモジュレーターとしてのベンゾイミダゾール誘導体 |
| JP2008525240A Expired - Fee Related JP5203193B2 (ja) | 2005-08-04 | 2006-08-04 | サーチュイン調節化合物としてのイミダゾ［２，１−ｂ］チアゾール誘導体 |
| JP2008525242A Expired - Fee Related JP5203195B2 (ja) | 2005-08-04 | 2006-08-04 | サーチュインモジュレーターとしてのベンゾチアゾールおよびチアゾロピリジン |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008525273A Expired - Fee Related JP5203196B2 (ja) | 2005-08-04 | 2006-08-04 | サーチュインモジュレーターとしてのオキサゾロピリジン誘導体 |
| JP2012126044A Withdrawn JP2012211149A (ja) | 2005-08-04 | 2012-06-01 | サーチュインモジュレーターとしてのベンゾチアゾールおよびチアゾロピリジン |
| JP2012125926A Withdrawn JP2012214480A (ja) | 2005-08-04 | 2012-06-01 | サーチュイン調節化合物としてのイミダゾ［２，１−ｂ］チアゾール誘導体 |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US7345178B2 (enExample) |
| EP (7) | EP2388263A1 (enExample) |
| JP (7) | JP2009503117A (enExample) |
| CN (1) | CN103145738A (enExample) |
| AU (5) | AU2006278396A1 (enExample) |
| CA (5) | CA2618370A1 (enExample) |
| DK (1) | DK1910384T3 (enExample) |
| ES (3) | ES2431050T3 (enExample) |
| PL (1) | PL1910384T3 (enExample) |
| PT (1) | PT1910384E (enExample) |
| WO (5) | WO2007019416A1 (enExample) |
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| US11207518B2 (en) * | 2004-12-27 | 2021-12-28 | The Feinstein Institutes For Medical Research | Treating inflammatory disorders by stimulation of the cholinergic anti-inflammatory pathway |
| TWI427077B (zh) | 2004-12-30 | 2014-02-21 | Astex Therapeutics Ltd | 吡唑化合物及其用途和含有彼之藥學組成物 |
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