JP2009503117A5 - - Google Patents
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- JP2009503117A5 JP2009503117A5 JP2008525272A JP2008525272A JP2009503117A5 JP 2009503117 A5 JP2009503117 A5 JP 2009503117A5 JP 2008525272 A JP2008525272 A JP 2008525272A JP 2008525272 A JP2008525272 A JP 2008525272A JP 2009503117 A5 JP2009503117 A5 JP 2009503117A5
- Authority
- JP
- Japan
- Prior art keywords
- unsubstituted
- phenyl
- optionally substituted
- substituted
- independently selected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- -1 3,5-dinitrophenyl Chemical group 0.000 claims 92
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 56
- 230000003381 solubilizing effect Effects 0.000 claims 42
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims 35
- 150000001875 compounds Chemical class 0.000 claims 29
- 125000000217 alkyl group Chemical group 0.000 claims 22
- 229910052739 hydrogen Inorganic materials 0.000 claims 22
- 239000001257 hydrogen Substances 0.000 claims 22
- 239000000203 mixture Substances 0.000 claims 17
- 125000003226 pyrazolyl group Chemical group 0.000 claims 17
- 150000002431 hydrogen Chemical class 0.000 claims 14
- 150000003839 salts Chemical class 0.000 claims 13
- 125000002541 furyl group Chemical group 0.000 claims 12
- 229910052760 oxygen Inorganic materials 0.000 claims 12
- 125000001544 thienyl group Chemical group 0.000 claims 12
- 125000003762 3,4-dimethoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 claims 11
- 125000004076 pyridyl group Chemical class 0.000 claims 11
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 8
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 8
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 8
- 229910052717 sulfur Inorganic materials 0.000 claims 8
- 125000005809 3,4,5-trimethoxyphenyl group Chemical group [H]C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 claims 7
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims 7
- 125000000335 thiazolyl group Chemical group 0.000 claims 7
- 125000001072 heteroaryl group Chemical group 0.000 claims 6
- 125000001624 naphthyl group Chemical group 0.000 claims 6
- 125000003261 o-tolyl group Chemical group [H]C1=C([H])C(*)=C(C([H])=C1[H])C([H])([H])[H] 0.000 claims 6
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 claims 6
- 125000001424 substituent group Chemical group 0.000 claims 6
- 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 claims 5
- 125000004207 3-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(OC([H])([H])[H])=C1[H] 0.000 claims 5
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims 5
- 206010022489 Insulin Resistance Diseases 0.000 claims 4
- 125000002619 bicyclic group Chemical group 0.000 claims 4
- 125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 claims 4
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 4
- 125000000168 pyrrolyl group Chemical group 0.000 claims 4
- KLIDCXVFHGNTTM-UHFFFAOYSA-N 2,6-dimethoxyphenol Chemical group COC1=CC=CC(OC)=C1O KLIDCXVFHGNTTM-UHFFFAOYSA-N 0.000 claims 3
- 125000000389 2-pyrrolyl group Chemical group [H]N1C([*])=C([H])C([H])=C1[H] 0.000 claims 3
- 125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 claims 3
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 3
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 125000001041 indolyl group Chemical group 0.000 claims 3
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims 3
- 125000000842 isoxazolyl group Chemical group 0.000 claims 3
- 125000001715 oxadiazolyl group Chemical group 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 239000000651 prodrug Substances 0.000 claims 3
- 229940002612 prodrug Drugs 0.000 claims 3
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 3
- 125000001113 thiadiazolyl group Chemical group 0.000 claims 3
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical group C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 claims 2
- 125000004201 2,4-dichlorophenyl group Chemical group [H]C1=C([H])C(*)=C(Cl)C([H])=C1Cl 0.000 claims 2
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 2
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 2
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 2
- 125000000732 arylene group Chemical group 0.000 claims 2
- 125000002837 carbocyclic group Chemical group 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 125000002950 monocyclic group Chemical group 0.000 claims 2
- 125000006501 nitrophenyl group Chemical group 0.000 claims 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
- 125000001917 2,4-dinitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C(=C1*)[N+]([O-])=O)[N+]([O-])=O 0.000 claims 1
- ZYHQGITXIJDDKC-UHFFFAOYSA-N 2-[2-(2-aminophenyl)ethyl]aniline Chemical group NC1=CC=CC=C1CCC1=CC=CC=C1N ZYHQGITXIJDDKC-UHFFFAOYSA-N 0.000 claims 1
- 125000006276 2-bromophenyl group Chemical group [H]C1=C([H])C(Br)=C(*)C([H])=C1[H] 0.000 claims 1
- 125000004800 4-bromophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Br 0.000 claims 1
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 1
- UKJLNMAFNRKWGR-UHFFFAOYSA-N cyclohexatrienamine Chemical group NC1=CC=C=C[CH]1 UKJLNMAFNRKWGR-UHFFFAOYSA-N 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims 1
- 125000003373 pyrazinyl group Chemical group 0.000 claims 1
- 239000002510 pyrogen Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 0 **c1ccccc1C1=*c2ccccc2*1* Chemical compound **c1ccccc1C1=*c2ccccc2*1* 0.000 description 4
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70561205P | 2005-08-04 | 2005-08-04 | |
| US74178305P | 2005-12-02 | 2005-12-02 | |
| US77937006P | 2006-03-03 | 2006-03-03 | |
| US79227606P | 2006-04-14 | 2006-04-14 | |
| PCT/US2006/030660 WO2007019416A1 (en) | 2005-08-04 | 2006-08-04 | Benzimidazole derivatives as sirtuin modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009503117A JP2009503117A (ja) | 2009-01-29 |
| JP2009503117A5 true JP2009503117A5 (enExample) | 2009-09-24 |
Family
ID=37074951
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008525242A Expired - Fee Related JP5203195B2 (ja) | 2005-08-04 | 2006-08-04 | サーチュインモジュレーターとしてのベンゾチアゾールおよびチアゾロピリジン |
| JP2008525240A Expired - Fee Related JP5203193B2 (ja) | 2005-08-04 | 2006-08-04 | サーチュイン調節化合物としてのイミダゾ［２，１−ｂ］チアゾール誘導体 |
| JP2008525273A Expired - Fee Related JP5203196B2 (ja) | 2005-08-04 | 2006-08-04 | サーチュインモジュレーターとしてのオキサゾロピリジン誘導体 |
| JP2008525272A Pending JP2009503117A (ja) | 2005-08-04 | 2006-08-04 | サーチュインモジュレーターとしてのベンゾイミダゾール誘導体 |
| JP2008525241A Expired - Fee Related JP5203194B2 (ja) | 2005-08-04 | 2006-08-04 | サーチュイン調節因子としてのイミダゾピリジン誘導体 |
| JP2012126044A Withdrawn JP2012211149A (ja) | 2005-08-04 | 2012-06-01 | サーチュインモジュレーターとしてのベンゾチアゾールおよびチアゾロピリジン |
| JP2012125926A Withdrawn JP2012214480A (ja) | 2005-08-04 | 2012-06-01 | サーチュイン調節化合物としてのイミダゾ［２，１−ｂ］チアゾール誘導体 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008525242A Expired - Fee Related JP5203195B2 (ja) | 2005-08-04 | 2006-08-04 | サーチュインモジュレーターとしてのベンゾチアゾールおよびチアゾロピリジン |
| JP2008525240A Expired - Fee Related JP5203193B2 (ja) | 2005-08-04 | 2006-08-04 | サーチュイン調節化合物としてのイミダゾ［２，１−ｂ］チアゾール誘導体 |
| JP2008525273A Expired - Fee Related JP5203196B2 (ja) | 2005-08-04 | 2006-08-04 | サーチュインモジュレーターとしてのオキサゾロピリジン誘導体 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008525241A Expired - Fee Related JP5203194B2 (ja) | 2005-08-04 | 2006-08-04 | サーチュイン調節因子としてのイミダゾピリジン誘導体 |
| JP2012126044A Withdrawn JP2012211149A (ja) | 2005-08-04 | 2012-06-01 | サーチュインモジュレーターとしてのベンゾチアゾールおよびチアゾロピリジン |
| JP2012125926A Withdrawn JP2012214480A (ja) | 2005-08-04 | 2012-06-01 | サーチュイン調節化合物としてのイミダゾ［２，１−ｂ］チアゾール誘導体 |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US7345178B2 (enExample) |
| EP (7) | EP1910384B1 (enExample) |
| JP (7) | JP5203195B2 (enExample) |
| CN (1) | CN103145738A (enExample) |
| AU (5) | AU2006278504B2 (enExample) |
| CA (5) | CA2618360C (enExample) |
| DK (1) | DK1910384T3 (enExample) |
| ES (3) | ES2431050T3 (enExample) |
| PL (1) | PL1910384T3 (enExample) |
| PT (1) | PT1910384E (enExample) |
| WO (5) | WO2007019416A1 (enExample) |
Families Citing this family (232)
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| EP3006040B1 (en) * | 2004-06-04 | 2017-11-22 | Washington University | Methods and compositions for treating neuropathies |
| ATE489132T1 (de) * | 2004-12-27 | 2010-12-15 | The Feinstein Inst Medical Res | Behandlung von entzündlichen erkrankungen durch elektrische stimulation des vagus-nervs |
| US11207518B2 (en) * | 2004-12-27 | 2021-12-28 | The Feinstein Institutes For Medical Research | Treating inflammatory disorders by stimulation of the cholinergic anti-inflammatory pathway |
| US8110573B2 (en) | 2004-12-30 | 2012-02-07 | Astex Therapeutics Limited | Pyrazole compounds that modulate the activity of CDK, GSK and aurora kinases |
| EP1850840A2 (en) * | 2005-01-13 | 2007-11-07 | Sirtris Pharmaceuticals, Inc. | Novel compositions for preventing and treating neurodegenerative and blood coagulation disorders |
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| CN101679266B (zh) | 2007-03-01 | 2015-05-06 | 诺华股份有限公司 | Pim激酶抑制剂及其应用方法 |
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| US9370642B2 (en) | 2007-06-29 | 2016-06-21 | J.W. Medical Systems Ltd. | Adjustable-length drug delivery balloon |
| CA2685599A1 (en) * | 2007-07-23 | 2009-01-29 | Summit Corporation Plc | Compounds for treating duchenne muscular dystrophy |
| PT2170396T (pt) | 2007-08-03 | 2017-03-31 | Summit Corp Plc | Combinação de fármacos para o tratamento da distrofia muscular de duchenne |
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| CA2699908C (en) * | 2007-09-20 | 2012-09-11 | Resveratrol Partners, Llc | Resveratrol-containing compositions for modulating gene product concentration or activity |
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| US20110082189A1 (en) * | 2007-10-23 | 2011-04-07 | President And Fellows Of Harvard College | Use of compounds activating sirt-3 for mimicking exercise |
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