MXPA05012120A - 2-imidazo-benzotiazoles como ligandos de receptores de adenosina. - Google Patents

2-imidazo-benzotiazoles como ligandos de receptores de adenosina.

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Publication number
MXPA05012120A
MXPA05012120A MXPA05012120A MXPA05012120A MXPA05012120A MX PA05012120 A MXPA05012120 A MX PA05012120A MX PA05012120 A MXPA05012120 A MX PA05012120A MX PA05012120 A MXPA05012120 A MX PA05012120A MX PA05012120 A MXPA05012120 A MX PA05012120A
Authority
MX
Mexico
Prior art keywords
lower alkyl
hydrogen
thiophen
benzo
halogen
Prior art date
Application number
MXPA05012120A
Other languages
English (en)
Inventor
Roger David Norcross
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MXPA05012120A publication Critical patent/MXPA05012120A/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Addiction (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Saccharide Compounds (AREA)

Abstract

La invencion se refiere a 2-imidazo-benzotiazoles de la formula general (I), en donde R1 es fenilo o un heterociclo que contiene N y/u O; R2 es un imidazol o un imidazol anulado, seleccionado del grupo que consiste de las formulas a), b), c), d) o e); R3 es hidrogeno, fenilo, 2,3-dihidro-benzo[1,4] dioxin-6-ilo, benzo[b]tiofen-3-ilo, 3-metil-benzo[b]tiofen-2-ilo, tiofen-2-ilo, tiofen-3-ilo o tiofen-2-il-metilo, R4 es hidrogeno, -(CH2)nO-alquilo inferior o alquilo inferior; R5 es hidrogeno, alquilo inferior, halogeno, morfolinilo, -NR??R????, piperidinilo, sustituido opcionalmente por hidroxi o es pirrolidin-1-ilo; R6 es hidrogeno, bencilo o -(CH2)nO-alquilo inferior, R7 es hidrogeno, -C(O)O-alquilo inferior, -C(O)-C6H4-halogeno, -C(O)-C6H4-alquilo inferior, -C(O)-alquilo inferior, -C(O)-cicloalquilo, -C(O)-NR??R????, -C(O)-(CH2)nO-alquilo inferior, -S(O)2-alquilo inferior, -(CH2)nO-alquilo inferior, -C(O)-piridin-4-ilo, el anillo que puede ser sustituido por alquilo inferior, halogeno-alquilo inferior o por pirrol-1-il-metilo o es -(CH2)n-C(O)NR??R????; R??/R???? son independientemente uno del otro hidrogeno, alquilo inferior o -(CH2)n-tetrahidropiran-4-ilo, X es -CH2-, -NR??????- o -O-; R?????? es hidrogeno, -C(O)-alquilo inferior, -C(O)O-alquilo inferior,-C(O)-C6H4CH3 o bencilo; n es 1 o 2; y a sales de adicion de acido farmaceuticamente aceptables de los mismos. Estos compuestos son ligandos de receptores de adenosina y por lo tanto son adecuados para el tratamiento de enfermedades relacionadas con este receptor.
MXPA05012120A 2003-05-13 2004-05-06 2-imidazo-benzotiazoles como ligandos de receptores de adenosina. MXPA05012120A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03009842 2003-05-13
PCT/EP2004/004843 WO2004101558A1 (en) 2003-05-13 2004-05-06 2-imidazo-benzothiazoles as adenosine receptor ligands

Publications (1)

Publication Number Publication Date
MXPA05012120A true MXPA05012120A (es) 2006-02-08

Family

ID=33395778

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05012120A MXPA05012120A (es) 2003-05-13 2004-05-06 2-imidazo-benzotiazoles como ligandos de receptores de adenosina.

Country Status (15)

Country Link
US (1) US7122545B2 (es)
EP (1) EP1636217B1 (es)
JP (1) JP4408291B2 (es)
KR (1) KR100710453B1 (es)
CN (1) CN100372844C (es)
AT (1) ATE407133T1 (es)
AU (1) AU2004238508B2 (es)
BR (1) BRPI0410315A (es)
CA (1) CA2523959A1 (es)
DE (1) DE602004016328D1 (es)
ES (1) ES2313001T3 (es)
MX (1) MXPA05012120A (es)
PL (1) PL1636217T3 (es)
RU (1) RU2340612C2 (es)
WO (1) WO2004101558A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007019417A1 (en) * 2005-08-04 2007-02-15 Sirtris Pharmaceuticals, Inc. Oxazolopyridine derivatives as sirtuin modulators
TW200736252A (en) * 2006-01-27 2007-10-01 Astrazeneca Ab Novel heteroaryl substituted benzothiazoles
TW200813035A (en) 2006-06-19 2008-03-16 Astrazeneca Ab Novel heteroaryl substituted benzoxazoles
TW200901998A (en) 2007-03-06 2009-01-16 Astrazeneca Ab Novel 2-heteroaryl substituted benzothiophenes and benzofuranes
SG10201401169QA (en) * 2009-04-02 2014-05-29 Merck Serono Sa Dihydroorotate dehydrogenase inhibitors
WO2010114971A1 (en) * 2009-04-03 2010-10-07 Sepracor Inc. Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof
US8575336B2 (en) 2011-07-27 2013-11-05 Pfizer Limited Indazoles
WO2016164565A1 (en) * 2015-04-08 2016-10-13 University Of Delaware Trans-cycloheptenes and hetero-trans-cycloheptenes for bioorthogonal coupling
WO2018193090A2 (en) * 2017-04-21 2018-10-25 Amneal Pharmaceuticals Company Gmbh Process for preparation of eliglustat hemitartrate and intermediates thereof
AU2018320673B2 (en) 2017-08-21 2023-03-30 Merck Patent Gmbh Benzimidazole derivatives as adenosine receptor antagonists

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1260444B (it) * 1992-01-24 1996-04-09 Mario Brufani Derivati della 8-(1-amminocicloalchil)1,3-dialchilxantina, procedimenbto di preparazione e loro composizioni farmaceutiche antidepressive, nootropiche e psicostimolanti
US6037473A (en) * 1997-11-13 2000-03-14 Haarmann & Reimer Gmbh Use of substituted benzazoles as UV absorbers, new benzazoles and processes for their preparation
NZ516260A (en) * 1999-07-02 2004-08-27 Eisai Co Ltd Fused imidazole compounds and remedies for diabetes mellitus
KR100571161B1 (ko) * 2000-06-21 2006-04-17 에프. 호프만-라 로슈 아게 벤조티아졸 유도체
MXPA05012369A (es) * 2003-05-21 2006-02-02 Hoffmann La Roche Derivados de benzotiazol y uso de los mismos en el tratamiento de enfermedades relacionadas con el receptor a2a de adenosina.

Also Published As

Publication number Publication date
EP1636217A1 (en) 2006-03-22
JP4408291B2 (ja) 2010-02-03
CN100372844C (zh) 2008-03-05
AU2004238508B2 (en) 2009-11-19
KR100710453B1 (ko) 2007-04-24
US20040229862A1 (en) 2004-11-18
RU2005138546A (ru) 2006-07-27
AU2004238508A1 (en) 2004-11-25
EP1636217B1 (en) 2008-09-03
PL1636217T3 (pl) 2009-02-27
WO2004101558A1 (en) 2004-11-25
DE602004016328D1 (de) 2008-10-16
BRPI0410315A (pt) 2006-05-23
KR20060009928A (ko) 2006-02-01
US7122545B2 (en) 2006-10-17
RU2340612C2 (ru) 2008-12-10
ATE407133T1 (de) 2008-09-15
CN1780831A (zh) 2006-05-31
JP2006528215A (ja) 2006-12-14
ES2313001T3 (es) 2009-03-01
CA2523959A1 (en) 2004-11-25

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