MXPA04000532A - Derivados de 8-metoxi-(1,2,4)-triazolo(1,5-a)piridina y su uso como ligandos receptores de adenosina. - Google Patents
Derivados de 8-metoxi-(1,2,4)-triazolo(1,5-a)piridina y su uso como ligandos receptores de adenosina.Info
- Publication number
- MXPA04000532A MXPA04000532A MXPA04000532A MXPA04000532A MXPA04000532A MX PA04000532 A MXPA04000532 A MX PA04000532A MX PA04000532 A MXPA04000532 A MX PA04000532A MX PA04000532 A MXPA04000532 A MX PA04000532A MX PA04000532 A MXPA04000532 A MX PA04000532A
- Authority
- MX
- Mexico
- Prior art keywords
- lower alkyl
- adenosine receptor
- triazolo
- methoxy
- receptor ligands
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Psychology (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La invencion se refiere a un compuesto de la formula general en la cual R1 es fenilo o tiofenilo, en el cual los anillos pueden no estar substituidos o estar substituidos por uno o dos substituyentes, seleccionados entre los grupos que comprenden halogeno, trifluometilo, alquilo inferior, alcoxi inferior, acetilamino, acetilo, alquenilo inferior, -C (O) O-alquilo inferior o tio-alquilo inferior; R2 es fenilo o tiofenilo, en el cual los anillos pueden no estar substituidos o estar substituidos por uno o dos substituyentes, seleccionados entre los grupos que comprenden halogeno, alquilo inferior, halogeno-alquilo inferior, o alcoxi inferior; y a sus sales farmaceuticamente aceptables. Estos compuestos tienen una buena afinidad por el receptor de adenosina, y por lo tanto, pueden utilizarse para el tratamiento de enfermedades relacionadas con este receptor.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01117539 | 2001-07-20 | ||
PCT/EP2002/007661 WO2003010167A1 (en) | 2001-07-20 | 2002-07-10 | 8-methoxy-(1,2,4)triazolo(1,5-a)pyridine derivatives and their use as adenosine receptor ligands |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA04000532A true MXPA04000532A (es) | 2004-05-04 |
Family
ID=8178085
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA04000532A MXPA04000532A (es) | 2001-07-20 | 2002-07-10 | Derivados de 8-metoxi-(1,2,4)-triazolo(1,5-a)piridina y su uso como ligandos receptores de adenosina. |
Country Status (13)
Country | Link |
---|---|
US (1) | US6514989B1 (es) |
EP (1) | EP1412352A1 (es) |
JP (1) | JP4105089B2 (es) |
KR (1) | KR100592939B1 (es) |
CN (1) | CN1264840C (es) |
AR (1) | AR034870A1 (es) |
AU (1) | AU2002325316B2 (es) |
BR (1) | BR0211206A (es) |
CA (1) | CA2453919A1 (es) |
MX (1) | MXPA04000532A (es) |
PL (1) | PL373414A1 (es) |
RU (1) | RU2297416C2 (es) |
WO (1) | WO2003010167A1 (es) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6693116B2 (en) * | 2001-10-08 | 2004-02-17 | Hoffmann-La Roche Inc. | Adenosine receptor ligands |
MXPA04005632A (es) * | 2001-12-12 | 2004-12-06 | Hoffmann La Roche | Benzotiofenos como moduladores de receptores de adenosina. |
MY139563A (en) * | 2002-09-04 | 2009-10-30 | Bristol Myers Squibb Co | Heterocyclic aromatic compounds useful as growth hormone secretagogues |
CN1830978B (zh) * | 2005-03-07 | 2010-06-16 | 中国人民解放军军事医学科学院毒物药物研究所 | 吡唑并[4,3-c]喹啉-3-酮化合物、其制备方法及其应用 |
WO2008063712A1 (en) * | 2006-06-22 | 2008-05-29 | Cv Therapeutics, Inc. | Use of a2a adenosine receptor agonists in the treatment of ischemia |
EP1894931A1 (en) * | 2006-08-30 | 2008-03-05 | Cellzome Ag | Triazole derivatives as kinase inhibitors |
SG174086A1 (en) * | 2006-08-30 | 2011-09-29 | Cellzome Ltd | Triazole derivatives as kinase inhibitors |
HUP0700395A2 (en) | 2007-06-07 | 2009-03-02 | Sanofi Aventis | Substituted [1,2,4] triazolo [1,5-a] quinolines, process for their preparation, pharmaceutical compositions thereof, and intermediates |
GB0719803D0 (en) | 2007-10-10 | 2007-11-21 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
SG186040A1 (en) * | 2007-11-27 | 2012-12-28 | Cellzome Ltd | Amino triazoles as pi3k inhibitors |
JP5595389B2 (ja) * | 2008-06-20 | 2014-09-24 | ジェネンテック, インコーポレイテッド | トリアゾロピリジンjak阻害剤化合物と方法 |
JP5512665B2 (ja) * | 2008-06-20 | 2014-06-04 | ジェネンテック, インコーポレイテッド | トリアゾロピリジンjak阻害剤化合物と方法 |
WO2010010188A1 (en) * | 2008-07-25 | 2010-01-28 | Galapagos Nv | Novel compounds useful for the treatment of degenerative and inflammatory diseases. |
JO3041B1 (ar) * | 2008-07-25 | 2016-09-05 | Galapagos Nv | مركبات جديدة مفيدة لمعالجة الأمراض التنكسية والالتهابية |
TWI453207B (zh) * | 2008-09-08 | 2014-09-21 | Signal Pharm Llc | 胺基三唑并吡啶,其組合物及使用其之治療方法 |
ES2570769T3 (es) * | 2008-12-19 | 2016-05-20 | Leo Pharma As | Triazolopiridinas como inhibidores fosfodiesterasa para el tratamiento de enfermedades dérmicas |
EP2438066A2 (en) | 2009-06-05 | 2012-04-11 | Cephalon, Inc. | PREPARATION AND USES OF 1,2,4-TRIAZOLO [1,5a]PYRIDINE DERIVATIVES |
JO3030B1 (ar) * | 2009-06-26 | 2016-09-05 | Galapagos Nv | مركب جديد مفيد لمعالجة الامراض التنكسية والالتهابات |
TWI462920B (zh) | 2009-06-26 | 2014-12-01 | 葛萊伯格有限公司 | 用於治療退化性及發炎疾病之新穎化合物 |
AU2010271732B2 (en) * | 2009-07-17 | 2016-08-25 | Japan Tobacco Inc. | Triazolopyridine compound, and action thereof as prolyl hydroxylase inhibitor and erythropoietin production inducer |
EP2343297A1 (en) | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Triazolopyridines |
US8080568B1 (en) * | 2010-06-29 | 2011-12-20 | Ewha University - Industry Collaboration Foundation | 2-pyridyl substituted imidazoles as therapeutic ALK5 and/or ALK4 inhibitors |
ES2552514T3 (es) * | 2011-11-03 | 2015-11-30 | Hoffmann-La Roche Ag | Compuestos bicíclicos de piperazina |
EP2794603B1 (en) * | 2011-12-21 | 2016-06-15 | Leo Pharma A/S | [1,2,4]triazolopyridines and their use as phospodiesterase inhibitors |
CN104284896B (zh) | 2012-03-14 | 2016-06-01 | 拜耳知识产权有限责任公司 | 取代的咪唑并哒嗪 |
WO2014198647A2 (en) | 2013-06-11 | 2014-12-18 | Bayer Pharma Aktiengesellschaft | Prodrug derivatives of substituted triazolopyridines |
RU2563254C2 (ru) * | 2013-07-08 | 2015-09-20 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | Способ получения производных 7-(гетеро)арил-4,5,6,7-тетрагидро[1,2,3]триазоло[1,5-a]пиридина |
GB201402070D0 (en) | 2014-02-07 | 2014-03-26 | Galapagos Nv | Pharmaceutical compositions for the treatment of inflammatory disorders |
GB201402071D0 (en) | 2014-02-07 | 2014-03-26 | Galapagos Nv | Novel salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
AR117291A1 (es) | 2018-12-14 | 2021-07-28 | Syngenta Crop Protection Ag | Compuestos heterocíclicos de cianamida con actividad pesticida |
WO2020192762A1 (zh) * | 2019-03-28 | 2020-10-01 | 基石药业(苏州)有限公司 | 一种a2a受体拮抗剂的盐型、晶型及其制备方法 |
EP4011880A4 (en) * | 2019-08-06 | 2023-09-13 | Jiangsu Carephar Pharmaceutical Co., Ltd | JAK KINASE INHIBITOR AND USE THEREOF |
CN114907182A (zh) * | 2019-09-09 | 2022-08-16 | 武汉诺安药业有限公司 | 一种4-碘代叔戊基苯的清洁制备方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9226735D0 (en) | 1992-12-22 | 1993-02-17 | Ici Plc | Azole derivatives |
US5571775A (en) | 1994-07-11 | 1996-11-05 | Dowelanco | N-aryl[1,2,4]triazolo[1,5-a]pyridine-2-sulfonamide herbicides |
US6355653B1 (en) | 1999-09-06 | 2002-03-12 | Hoffmann-La Roche Inc. | Amino-triazolopyridine derivatives |
-
2002
- 2002-05-29 US US10/157,346 patent/US6514989B1/en not_active Expired - Fee Related
- 2002-07-10 EP EP02758330A patent/EP1412352A1/en not_active Withdrawn
- 2002-07-10 WO PCT/EP2002/007661 patent/WO2003010167A1/en active Application Filing
- 2002-07-10 CA CA002453919A patent/CA2453919A1/en not_active Abandoned
- 2002-07-10 JP JP2003515526A patent/JP4105089B2/ja not_active Expired - Fee Related
- 2002-07-10 RU RU2004105260/04A patent/RU2297416C2/ru not_active IP Right Cessation
- 2002-07-10 MX MXPA04000532A patent/MXPA04000532A/es active IP Right Grant
- 2002-07-10 PL PL02373414A patent/PL373414A1/xx not_active Application Discontinuation
- 2002-07-10 BR BR0211206-0A patent/BR0211206A/pt not_active IP Right Cessation
- 2002-07-10 CN CNB028145089A patent/CN1264840C/zh not_active Expired - Fee Related
- 2002-07-10 KR KR1020047000914A patent/KR100592939B1/ko not_active IP Right Cessation
- 2002-07-10 AU AU2002325316A patent/AU2002325316B2/en not_active Ceased
- 2002-07-18 AR ARP020102688A patent/AR034870A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
CN1541216A (zh) | 2004-10-27 |
EP1412352A1 (en) | 2004-04-28 |
WO2003010167A1 (en) | 2003-02-06 |
AR034870A1 (es) | 2004-03-24 |
CA2453919A1 (en) | 2003-02-06 |
RU2004105260A (ru) | 2005-07-10 |
JP4105089B2 (ja) | 2008-06-18 |
CN1264840C (zh) | 2006-07-19 |
AU2002325316B8 (en) | 2003-02-17 |
RU2297416C2 (ru) | 2007-04-20 |
KR20040023667A (ko) | 2004-03-18 |
BR0211206A (pt) | 2004-07-13 |
KR100592939B1 (ko) | 2006-06-26 |
AU2002325316B2 (en) | 2007-11-01 |
US6514989B1 (en) | 2003-02-04 |
JP2005511492A (ja) | 2005-04-28 |
PL373414A1 (en) | 2005-08-22 |
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Legal Events
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