AR034870A1 - Derivados de 8-metoxi-[1,2,4]triazolo[1,5-a]piridina - Google Patents
Derivados de 8-metoxi-[1,2,4]triazolo[1,5-a]piridinaInfo
- Publication number
- AR034870A1 AR034870A1 ARP020102688A ARP020102688A AR034870A1 AR 034870 A1 AR034870 A1 AR 034870A1 AR P020102688 A ARP020102688 A AR P020102688A AR P020102688 A ARP020102688 A AR P020102688A AR 034870 A1 AR034870 A1 AR 034870A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- lower alkyl
- halogen
- compounds
- metoxi
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Compuestos de la fórmula general (1) en la cual R1 es fenilo o tiofenilo, en el cual los anillos pueden no estar sustituidos o estar sustituidos por uno o dos sustituyentes, seleccionados entre los grupos que comprenden halógeno, trifluometilo, alquilo inferior, alcoxi inferior, acetilamino, acetilo, alquenilo inferior, -C(O)O-alquilo inferior o tioalquilo inferior; R2 es fenilo o tiofenilo, en el cual los anillos pueden no estar sustituidos o estar sustituidos por uno o dos sustituyentes, seleccionados entre los grupos que comprenden halógeno, alquilo inferior, halógeno-alquilo inferior, o alcoxi inferior; y sus sales farmacéuticamente aceptables. Estos compuestos tienen una afinidad con el receptor de adenosina, y por lo tanto pueden utilizarse para el tratamiento de enfermedades relacionadas con este receptor. Medicamentos, Procedimiento para preparar los compuestos y su uso.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01117539 | 2001-07-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR034870A1 true AR034870A1 (es) | 2004-03-24 |
Family
ID=8178085
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP020102688A AR034870A1 (es) | 2001-07-20 | 2002-07-18 | Derivados de 8-metoxi-[1,2,4]triazolo[1,5-a]piridina |
Country Status (13)
Country | Link |
---|---|
US (1) | US6514989B1 (es) |
EP (1) | EP1412352A1 (es) |
JP (1) | JP4105089B2 (es) |
KR (1) | KR100592939B1 (es) |
CN (1) | CN1264840C (es) |
AR (1) | AR034870A1 (es) |
AU (1) | AU2002325316B2 (es) |
BR (1) | BR0211206A (es) |
CA (1) | CA2453919A1 (es) |
MX (1) | MXPA04000532A (es) |
PL (1) | PL373414A1 (es) |
RU (1) | RU2297416C2 (es) |
WO (1) | WO2003010167A1 (es) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6693116B2 (en) * | 2001-10-08 | 2004-02-17 | Hoffmann-La Roche Inc. | Adenosine receptor ligands |
CN1296368C (zh) * | 2001-12-12 | 2007-01-24 | 弗·哈夫曼-拉罗切有限公司 | 用作腺苷受体调节剂的苯并噻吩化合物 |
MY139563A (en) * | 2002-09-04 | 2009-10-30 | Bristol Myers Squibb Co | Heterocyclic aromatic compounds useful as growth hormone secretagogues |
CN1830978B (zh) * | 2005-03-07 | 2010-06-16 | 中国人民解放军军事医学科学院毒物药物研究所 | 吡唑并[4,3-c]喹啉-3-酮化合物、其制备方法及其应用 |
JP2009541354A (ja) * | 2006-06-22 | 2009-11-26 | シーブイ・セラピューティクス・インコーポレイテッド | 虚血の治療におけるa2aアデノシン受容体アゴニストの使用 |
ES2549862T3 (es) * | 2006-08-30 | 2015-11-02 | Cellzome Limited | Derivados de triazol como inhibidores de quinasa |
EP1894931A1 (en) * | 2006-08-30 | 2008-03-05 | Cellzome Ag | Triazole derivatives as kinase inhibitors |
HUP0700395A2 (en) | 2007-06-07 | 2009-03-02 | Sanofi Aventis | Substituted [1,2,4] triazolo [1,5-a] quinolines, process for their preparation, pharmaceutical compositions thereof, and intermediates |
GB0719803D0 (en) | 2007-10-10 | 2007-11-21 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
US8865699B2 (en) * | 2007-11-27 | 2014-10-21 | Cellzome Ltd. | Amino triazoles as PI3K inhibitors |
WO2009155551A1 (en) * | 2008-06-20 | 2009-12-23 | Genentech, Inc. | Triazolopyridine jak inhibitor compounds and methods |
BRPI0909945A2 (pt) * | 2008-06-20 | 2015-07-28 | Genentech Inc | "composto, composição farmacêutica, método para tratar ou atenuar a gravidade de uma doença ou condição responsiva à inibição da atividade jak2 quinase em um paciente, kit para o tratamento de uma doença ou distúrbio responsivo à inibição da jak quinase" |
JO3041B1 (ar) | 2008-07-25 | 2016-09-05 | Galapagos Nv | مركبات جديدة مفيدة لمعالجة الأمراض التنكسية والالتهابية |
WO2010010188A1 (en) * | 2008-07-25 | 2010-01-28 | Galapagos Nv | Novel compounds useful for the treatment of degenerative and inflammatory diseases. |
TWI453207B (zh) | 2008-09-08 | 2014-09-21 | Signal Pharm Llc | 胺基三唑并吡啶,其組合物及使用其之治療方法 |
ES2570769T3 (es) * | 2008-12-19 | 2016-05-20 | Leo Pharma As | Triazolopiridinas como inhibidores fosfodiesterasa para el tratamiento de enfermedades dérmicas |
AU2010254806C1 (en) | 2009-06-05 | 2016-07-07 | Cephalon, Inc. | Preparation and uses of 1,2,4-triazolo [1,5a] pyridine derivatives |
JO3030B1 (ar) | 2009-06-26 | 2016-09-05 | Galapagos Nv | مركب جديد مفيد لمعالجة الامراض التنكسية والالتهابات |
TWI462920B (zh) * | 2009-06-26 | 2014-12-01 | 葛萊伯格有限公司 | 用於治療退化性及發炎疾病之新穎化合物 |
EP2746282A1 (en) * | 2009-07-17 | 2014-06-25 | Japan Tobacco Inc. | Triazolopyridine compound, and action thereof as prolyl hydroxylase inhibitor and erythropoietin production inducer |
EP2343297A1 (en) | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Triazolopyridines |
US8080568B1 (en) * | 2010-06-29 | 2011-12-20 | Ewha University - Industry Collaboration Foundation | 2-pyridyl substituted imidazoles as therapeutic ALK5 and/or ALK4 inhibitors |
CA2852964A1 (en) * | 2011-11-03 | 2013-05-10 | F. Hoffmann-La Roche Ag | Bicyclic piperazine compounds |
MX2014006812A (es) * | 2011-12-21 | 2014-10-13 | Leo Pharma As | [1,2,4] triazolopiridinas y su uso como inhibidores de fosfodiesterasa. |
JP6166289B2 (ja) | 2012-03-14 | 2017-07-19 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングBayer Intellectual Property GmbH | 置換イミダゾピリダジン |
RS56034B1 (sr) | 2013-06-11 | 2017-09-29 | Bayer Pharma AG | Derivati prolekova supstituisanih triazolopiridina |
RU2563254C2 (ru) * | 2013-07-08 | 2015-09-20 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | Способ получения производных 7-(гетеро)арил-4,5,6,7-тетрагидро[1,2,3]триазоло[1,5-a]пиридина |
GB201402070D0 (en) | 2014-02-07 | 2014-03-26 | Galapagos Nv | Pharmaceutical compositions for the treatment of inflammatory disorders |
GB201402071D0 (en) | 2014-02-07 | 2014-03-26 | Galapagos Nv | Novel salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
AR117291A1 (es) | 2018-12-14 | 2021-07-28 | Syngenta Crop Protection Ag | Compuestos heterocíclicos de cianamida con actividad pesticida |
US20220185825A1 (en) * | 2019-03-28 | 2022-06-16 | Cstone Pharmaceutical (Suzhou) Co., Ltd. | Salt form and crystal form of a2a receptor antagonist and preparation method therefor |
WO2021023207A1 (zh) * | 2019-08-06 | 2021-02-11 | 江苏柯菲平医药股份有限公司 | Jak激酶抑制剂及其用途 |
CN110498729A (zh) * | 2019-09-09 | 2019-11-26 | 武汉诺安药业有限公司 | 一种盐酸阿莫罗芬中间体的清洁制备方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9226735D0 (en) | 1992-12-22 | 1993-02-17 | Ici Plc | Azole derivatives |
US5571775A (en) | 1994-07-11 | 1996-11-05 | Dowelanco | N-aryl[1,2,4]triazolo[1,5-a]pyridine-2-sulfonamide herbicides |
US6355653B1 (en) | 1999-09-06 | 2002-03-12 | Hoffmann-La Roche Inc. | Amino-triazolopyridine derivatives |
-
2002
- 2002-05-29 US US10/157,346 patent/US6514989B1/en not_active Expired - Fee Related
- 2002-07-10 RU RU2004105260/04A patent/RU2297416C2/ru not_active IP Right Cessation
- 2002-07-10 BR BR0211206-0A patent/BR0211206A/pt not_active IP Right Cessation
- 2002-07-10 KR KR1020047000914A patent/KR100592939B1/ko not_active IP Right Cessation
- 2002-07-10 CN CNB028145089A patent/CN1264840C/zh not_active Expired - Fee Related
- 2002-07-10 WO PCT/EP2002/007661 patent/WO2003010167A1/en active Application Filing
- 2002-07-10 CA CA002453919A patent/CA2453919A1/en not_active Abandoned
- 2002-07-10 JP JP2003515526A patent/JP4105089B2/ja not_active Expired - Fee Related
- 2002-07-10 EP EP02758330A patent/EP1412352A1/en not_active Withdrawn
- 2002-07-10 AU AU2002325316A patent/AU2002325316B2/en not_active Ceased
- 2002-07-10 PL PL02373414A patent/PL373414A1/xx not_active Application Discontinuation
- 2002-07-10 MX MXPA04000532A patent/MXPA04000532A/es active IP Right Grant
- 2002-07-18 AR ARP020102688A patent/AR034870A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
PL373414A1 (en) | 2005-08-22 |
CN1264840C (zh) | 2006-07-19 |
MXPA04000532A (es) | 2004-05-04 |
AU2002325316B8 (en) | 2003-02-17 |
CA2453919A1 (en) | 2003-02-06 |
AU2002325316B2 (en) | 2007-11-01 |
RU2004105260A (ru) | 2005-07-10 |
CN1541216A (zh) | 2004-10-27 |
RU2297416C2 (ru) | 2007-04-20 |
KR100592939B1 (ko) | 2006-06-26 |
BR0211206A (pt) | 2004-07-13 |
JP4105089B2 (ja) | 2008-06-18 |
EP1412352A1 (en) | 2004-04-28 |
KR20040023667A (ko) | 2004-03-18 |
WO2003010167A1 (en) | 2003-02-06 |
US6514989B1 (en) | 2003-02-04 |
JP2005511492A (ja) | 2005-04-28 |
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Legal Events
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