BR0211206A - Derivados de 8-metóxi-(1,2,4)triazolo(1, 5-a)piridina e seus usos como ligantes do receptor de adenosina - Google Patents
Derivados de 8-metóxi-(1,2,4)triazolo(1, 5-a)piridina e seus usos como ligantes do receptor de adenosinaInfo
- Publication number
- BR0211206A BR0211206A BR0211206-0A BR0211206A BR0211206A BR 0211206 A BR0211206 A BR 0211206A BR 0211206 A BR0211206 A BR 0211206A BR 0211206 A BR0211206 A BR 0211206A
- Authority
- BR
- Brazil
- Prior art keywords
- adenosine receptor
- methoxy
- pyridine derivatives
- halogen
- lower alkyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
"DERIVADOS DE 8-METóXI-(1,2,4)TRIAZOLO(1, 5-A)PIRIDINA E SEUS USOS COMO LIGANTES DO RECEPTOR DE ADENOSINA". A presente invenção refere-se a um composto de fórmula geral (I) em que R^ 1^ é fenila ou tiofenila, em que os anéis podem ser não substituídos ou substituídos por um ou dois substituintes selecionados dos grupos constituídos de halogênio, trifluormetila, alquila inferior, alcóxi inferior, acetilamino, acetila, alquenila inferior, -C(O)O-alquila inferior ou tio-alquila inferior; R^ 2^ é fenila ou tiofenila, em que os anéis podem ser não substituídos ou substituídos por um ou dois substituintes selecionados dos grupos constituídos de halogênio, alquila inferior, halogênio-alquila inferior ou alcóxi inferior; e seus sais farmaceuticamente aceitáveis. Esses compostos têm uma boa afinidade para com o receptor de adenosina e portanto podem ser usados para o tratamento de doenças relacionadas com este receptor.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01117539 | 2001-07-20 | ||
PCT/EP2002/007661 WO2003010167A1 (en) | 2001-07-20 | 2002-07-10 | 8-methoxy-(1,2,4)triazolo(1,5-a)pyridine derivatives and their use as adenosine receptor ligands |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0211206A true BR0211206A (pt) | 2004-07-13 |
Family
ID=8178085
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0211206-0A BR0211206A (pt) | 2001-07-20 | 2002-07-10 | Derivados de 8-metóxi-(1,2,4)triazolo(1, 5-a)piridina e seus usos como ligantes do receptor de adenosina |
Country Status (13)
Country | Link |
---|---|
US (1) | US6514989B1 (pt) |
EP (1) | EP1412352A1 (pt) |
JP (1) | JP4105089B2 (pt) |
KR (1) | KR100592939B1 (pt) |
CN (1) | CN1264840C (pt) |
AR (1) | AR034870A1 (pt) |
AU (1) | AU2002325316B2 (pt) |
BR (1) | BR0211206A (pt) |
CA (1) | CA2453919A1 (pt) |
MX (1) | MXPA04000532A (pt) |
PL (1) | PL373414A1 (pt) |
RU (1) | RU2297416C2 (pt) |
WO (1) | WO2003010167A1 (pt) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6693116B2 (en) * | 2001-10-08 | 2004-02-17 | Hoffmann-La Roche Inc. | Adenosine receptor ligands |
WO2003053954A1 (en) * | 2001-12-12 | 2003-07-03 | F. Hoffmann-La Roche Ag | Benzothiophenes as adenosine receptor modulators |
MY139563A (en) * | 2002-09-04 | 2009-10-30 | Bristol Myers Squibb Co | Heterocyclic aromatic compounds useful as growth hormone secretagogues |
CN1830978B (zh) * | 2005-03-07 | 2010-06-16 | 中国人民解放军军事医学科学院毒物药物研究所 | 吡唑并[4,3-c]喹啉-3-酮化合物、其制备方法及其应用 |
WO2008063712A1 (en) * | 2006-06-22 | 2008-05-29 | Cv Therapeutics, Inc. | Use of a2a adenosine receptor agonists in the treatment of ischemia |
EP1894931A1 (en) * | 2006-08-30 | 2008-03-05 | Cellzome Ag | Triazole derivatives as kinase inhibitors |
AU2007291190A1 (en) * | 2006-08-30 | 2008-03-06 | Cellzome Limited | Triazole derivatives as kinase inhibitors |
HUP0700395A2 (en) | 2007-06-07 | 2009-03-02 | Sanofi Aventis | Substituted [1,2,4] triazolo [1,5-a] quinolines, process for their preparation, pharmaceutical compositions thereof, and intermediates |
GB0719803D0 (en) * | 2007-10-10 | 2007-11-21 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
KR20100086492A (ko) * | 2007-11-27 | 2010-07-30 | 셀좀 리미티드 | Pi3k 억제제로서의 아미노 트리아졸 |
KR20110031475A (ko) | 2008-06-20 | 2011-03-28 | 제넨테크, 인크. | 트리아졸로피리딘 jak 억제제 화합물 및 방법 |
MX2010014005A (es) * | 2008-06-20 | 2011-02-15 | Genentech Inc | Compuestos de triazolopiridina inhibidores de jak y los metodos. |
JO3041B1 (ar) | 2008-07-25 | 2016-09-05 | Galapagos Nv | مركبات جديدة مفيدة لمعالجة الأمراض التنكسية والالتهابية |
WO2010010188A1 (en) * | 2008-07-25 | 2010-01-28 | Galapagos Nv | Novel compounds useful for the treatment of degenerative and inflammatory diseases. |
TWI453207B (zh) | 2008-09-08 | 2014-09-21 | Signal Pharm Llc | 胺基三唑并吡啶,其組合物及使用其之治療方法 |
CN102317287B (zh) * | 2008-12-19 | 2014-10-08 | 利奥制药有限公司 | 作为磷酸二酯酶抑制剂、用于治疗皮肤病的三唑并吡啶化合物 |
EP2438066A2 (en) | 2009-06-05 | 2012-04-11 | Cephalon, Inc. | PREPARATION AND USES OF 1,2,4-TRIAZOLO [1,5a]PYRIDINE DERIVATIVES |
JO3030B1 (ar) * | 2009-06-26 | 2016-09-05 | Galapagos Nv | مركب جديد مفيد لمعالجة الامراض التنكسية والالتهابات |
TWI462920B (zh) | 2009-06-26 | 2014-12-01 | 葛萊伯格有限公司 | 用於治療退化性及發炎疾病之新穎化合物 |
NZ598242A (en) * | 2009-07-17 | 2013-09-27 | Japan Tobacco Inc | Triazolopyridine compound, and action thereof as prolyl hydroxylase inhibitor and erythropoietin production inducer |
EP2343297A1 (en) | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Triazolopyridines |
US8080568B1 (en) * | 2010-06-29 | 2011-12-20 | Ewha University - Industry Collaboration Foundation | 2-pyridyl substituted imidazoles as therapeutic ALK5 and/or ALK4 inhibitors |
CA2852964A1 (en) * | 2011-11-03 | 2013-05-10 | F. Hoffmann-La Roche Ag | Bicyclic piperazine compounds |
AU2012357106A1 (en) * | 2011-12-21 | 2014-06-05 | Leo Pharma A/S | [1,2,4]triazolopyridines and their use as phospodiesterase inhibitors |
US9512126B2 (en) | 2012-03-14 | 2016-12-06 | Bayer Intellectual Property Gmbh | Substituted imidazopyridazines |
SG11201509858QA (en) | 2013-06-11 | 2015-12-30 | Bayer Pharma AG | Prodrug derivatives of substituted triazolopyridines |
RU2563254C2 (ru) * | 2013-07-08 | 2015-09-20 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | Способ получения производных 7-(гетеро)арил-4,5,6,7-тетрагидро[1,2,3]триазоло[1,5-a]пиридина |
GB201402071D0 (en) | 2014-02-07 | 2014-03-26 | Galapagos Nv | Novel salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
GB201402070D0 (en) | 2014-02-07 | 2014-03-26 | Galapagos Nv | Pharmaceutical compositions for the treatment of inflammatory disorders |
AR117291A1 (es) | 2018-12-14 | 2021-07-28 | Syngenta Crop Protection Ag | Compuestos heterocíclicos de cianamida con actividad pesticida |
US20220185825A1 (en) * | 2019-03-28 | 2022-06-16 | Cstone Pharmaceutical (Suzhou) Co., Ltd. | Salt form and crystal form of a2a receptor antagonist and preparation method therefor |
EP4011880A4 (en) * | 2019-08-06 | 2023-09-13 | Jiangsu Carephar Pharmaceutical Co., Ltd | JAK KINASE INHIBITOR AND USE THEREOF |
CN114907182A (zh) * | 2019-09-09 | 2022-08-16 | 武汉诺安药业有限公司 | 一种4-碘代叔戊基苯的清洁制备方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9226735D0 (en) | 1992-12-22 | 1993-02-17 | Ici Plc | Azole derivatives |
US5571775A (en) | 1994-07-11 | 1996-11-05 | Dowelanco | N-aryl[1,2,4]triazolo[1,5-a]pyridine-2-sulfonamide herbicides |
US6355653B1 (en) | 1999-09-06 | 2002-03-12 | Hoffmann-La Roche Inc. | Amino-triazolopyridine derivatives |
-
2002
- 2002-05-29 US US10/157,346 patent/US6514989B1/en not_active Expired - Fee Related
- 2002-07-10 JP JP2003515526A patent/JP4105089B2/ja not_active Expired - Fee Related
- 2002-07-10 CA CA002453919A patent/CA2453919A1/en not_active Abandoned
- 2002-07-10 BR BR0211206-0A patent/BR0211206A/pt not_active IP Right Cessation
- 2002-07-10 MX MXPA04000532A patent/MXPA04000532A/es active IP Right Grant
- 2002-07-10 WO PCT/EP2002/007661 patent/WO2003010167A1/en active Application Filing
- 2002-07-10 RU RU2004105260/04A patent/RU2297416C2/ru not_active IP Right Cessation
- 2002-07-10 PL PL02373414A patent/PL373414A1/xx not_active Application Discontinuation
- 2002-07-10 EP EP02758330A patent/EP1412352A1/en not_active Withdrawn
- 2002-07-10 AU AU2002325316A patent/AU2002325316B2/en not_active Ceased
- 2002-07-10 CN CNB028145089A patent/CN1264840C/zh not_active Expired - Fee Related
- 2002-07-10 KR KR1020047000914A patent/KR100592939B1/ko not_active IP Right Cessation
- 2002-07-18 AR ARP020102688A patent/AR034870A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
JP4105089B2 (ja) | 2008-06-18 |
WO2003010167A1 (en) | 2003-02-06 |
EP1412352A1 (en) | 2004-04-28 |
AR034870A1 (es) | 2004-03-24 |
PL373414A1 (en) | 2005-08-22 |
CN1541216A (zh) | 2004-10-27 |
CA2453919A1 (en) | 2003-02-06 |
KR20040023667A (ko) | 2004-03-18 |
AU2002325316B2 (en) | 2007-11-01 |
AU2002325316B8 (en) | 2003-02-17 |
KR100592939B1 (ko) | 2006-06-26 |
US6514989B1 (en) | 2003-02-04 |
RU2297416C2 (ru) | 2007-04-20 |
RU2004105260A (ru) | 2005-07-10 |
CN1264840C (zh) | 2006-07-19 |
JP2005511492A (ja) | 2005-04-28 |
MXPA04000532A (es) | 2004-05-04 |
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Legal Events
Date | Code | Title | Description |
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B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B15K | Others concerning applications: alteration of classification |
Free format text: PARA INT.CL: C07D 471/04, A61K 31/41, A61P 11/00 Ipc: C07D 471/04 (2011.01), A61K 31/41 (2011.01) |
|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A E 9A A NUIDADES. |
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B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2108 DE 31/05/2011. |