MX2011012198A - Aril-piridinas como inhibidoras de sintasa de aldosterona. - Google Patents
Aril-piridinas como inhibidoras de sintasa de aldosterona.Info
- Publication number
- MX2011012198A MX2011012198A MX2011012198A MX2011012198A MX2011012198A MX 2011012198 A MX2011012198 A MX 2011012198A MX 2011012198 A MX2011012198 A MX 2011012198A MX 2011012198 A MX2011012198 A MX 2011012198A MX 2011012198 A MX2011012198 A MX 2011012198A
- Authority
- MX
- Mexico
- Prior art keywords
- synthase inhibitors
- aldosterone synthase
- aryl pyridine
- pyridine
- aryl
- Prior art date
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
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- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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Abstract
La presente invención proporciona un compuesto de la fórmula I: un método para la elaboración de los compuestos de la invención, y sus usos terapéuticos. La presente invención proporciona además una combinación de agentes farmacológicamente activos y una composición farmacéutica.
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US17867709P | 2009-05-15 | 2009-05-15 | |
US31841310P | 2010-03-29 | 2010-03-29 | |
PCT/EP2010/056572 WO2010130796A1 (en) | 2009-05-15 | 2010-05-12 | Aryl pyridine as aldosterone synthase inhibitors |
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MX2011012198A MX2011012198A (es) | 2009-05-15 | 2010-05-12 | Aril-piridinas como inhibidoras de sintasa de aldosterona. |
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US (3) | US8383827B2 (es) |
EP (1) | EP2429995B1 (es) |
JP (1) | JP5659224B2 (es) |
KR (1) | KR101338555B1 (es) |
CN (2) | CN104892502B (es) |
AR (1) | AR076908A1 (es) |
AU (1) | AU2010247414B2 (es) |
BR (1) | BRPI1010600A2 (es) |
CA (1) | CA2761859A1 (es) |
CL (1) | CL2011002857A1 (es) |
CO (1) | CO6470898A2 (es) |
CR (1) | CR20110592A (es) |
CU (1) | CU24045B1 (es) |
DK (1) | DK2429995T3 (es) |
EA (1) | EA020138B1 (es) |
EC (1) | ECSP11011526A (es) |
ES (1) | ES2459468T3 (es) |
HK (1) | HK1163666A1 (es) |
HR (1) | HRP20140371T1 (es) |
IL (1) | IL216187A0 (es) |
MA (1) | MA33358B1 (es) |
MX (1) | MX2011012198A (es) |
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PE (1) | PE20120403A1 (es) |
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PT (1) | PT2429995E (es) |
RS (1) | RS53275B (es) |
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SI (1) | SI2429995T1 (es) |
SV (1) | SV2011004061A (es) |
TW (1) | TWI454460B (es) |
UY (1) | UY32640A (es) |
WO (1) | WO2010130796A1 (es) |
ZA (1) | ZA201108155B (es) |
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