CU24045B1 - Aril piridinas como inhibidoras de sintasa de aldosterona - Google Patents

Aril piridinas como inhibidoras de sintasa de aldosterona

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Publication number
CU24045B1
CU24045B1 CU2011000207A CU20110207A CU24045B1 CU 24045 B1 CU24045 B1 CU 24045B1 CU 2011000207 A CU2011000207 A CU 2011000207A CU 20110207 A CU20110207 A CU 20110207A CU 24045 B1 CU24045 B1 CU 24045B1
Authority
CU
Cuba
Prior art keywords
inhibitors
piridinas
aldosterona
sintasa
aril
Prior art date
Application number
CU2011000207A
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English (en)
Other versions
CU20110207A7 (es
Inventor
Sylvie Chamoin
Qi-Ying Hu
Julien Papillon
Original Assignee
Novartis Ag
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Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CU20110207A7 publication Critical patent/CU20110207A7/es
Publication of CU24045B1 publication Critical patent/CU24045B1/es

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/76—Nitrogen atoms to which a second hetero atom is attached
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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Abstract

La presente invención proporciona un compuesto de la fórmula I: ESPACIO PARA LA FÓRMULA un método para la elaboración de los compuestos de la invención, y sus usos terapéuticos. Los compuestos de la presente invención son útiles como inhibidores de la actividad de la sintasa de aldosterona.
CU2011000207A 2009-05-15 2011-11-14 Aril piridinas como inhibidoras de sintasa de aldosterona CU24045B1 (es)

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