JP2018526416A5 - - Google Patents
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- JP2018526416A5 JP2018526416A5 JP2018512944A JP2018512944A JP2018526416A5 JP 2018526416 A5 JP2018526416 A5 JP 2018526416A5 JP 2018512944 A JP2018512944 A JP 2018512944A JP 2018512944 A JP2018512944 A JP 2018512944A JP 2018526416 A5 JP2018526416 A5 JP 2018526416A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- hydrogen
- alkyl
- aryl
- haloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562216168P | 2015-09-09 | 2015-09-09 | |
| US62/216,168 | 2015-09-09 | ||
| PCT/US2016/050685 WO2017044567A1 (en) | 2015-09-09 | 2016-09-08 | Heterocyclic constrained tricyclic sulfonamides as anti-cancer agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018526416A JP2018526416A (ja) | 2018-09-13 |
| JP2018526416A5 true JP2018526416A5 (enExample) | 2019-11-07 |
| JP6966425B2 JP6966425B2 (ja) | 2021-11-17 |
Family
ID=56940436
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018512944A Expired - Fee Related JP6966425B2 (ja) | 2015-09-09 | 2016-09-08 | 抗がん剤としての複素環式の限定された三環系スルホンアミド |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10221158B2 (enExample) |
| EP (1) | EP3347350A1 (enExample) |
| JP (1) | JP6966425B2 (enExample) |
| CN (1) | CN108349943A (enExample) |
| CA (1) | CA2997769A1 (enExample) |
| WO (1) | WO2017044567A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015138496A1 (en) | 2014-03-11 | 2015-09-17 | Icahn School Of Medicine At Mount Sinai | Constrained tricyclic sulfonamides |
| US9937186B2 (en) | 2014-03-11 | 2018-04-10 | Icahn School Of Medicine At Mount Sinai | Sulfonamides derived from tricyclyl-2-aminocycloalkanols as anticancer agents |
| CA2997784A1 (en) | 2015-09-09 | 2017-03-16 | Icahn School Of Medicine At Mount Sinai | Heterocyclic constrained tricyclic sulfonamides as anti-cancer agents |
| WO2021150695A1 (en) * | 2020-01-22 | 2021-07-29 | Icahn School Of Medicine At Mount Sinai | Constrained n-substituted tetrahydrobenzoazepine sulfonamides as anticancer and neuroprotective agents |
| US20230020161A1 (en) * | 2020-02-28 | 2023-01-19 | Rappta Therapeutics Oy | Tricyclic Modulators of PP2A |
| WO2021188949A1 (en) * | 2020-03-20 | 2021-09-23 | Atux Iskay Llc | 3-diarylmethylenes and uses thereof |
| CN114272378B (zh) * | 2020-09-27 | 2023-06-23 | 四川大学华西医院 | 一种使cttnbp2nl功能缺失的试剂在制备治疗疾病的药物中的用途 |
| JP2024508687A (ja) * | 2021-02-08 | 2024-02-28 | ラプタ セラピューティクス オーワイ | プロテインホスファターゼ２ａ（ｐｐ２ａ）の置換環状調節物質およびこれを用いた方法 |
| CN118119607A (zh) * | 2021-08-18 | 2024-05-31 | 阿图什伊斯卡伊有限责任公司 | 作为抗癌、抗炎、抗纤维和神经保护剂的2-二芳基甲基-4-氨基四氢吡喃衍生物及相关化合物 |
| JP2025525943A (ja) * | 2022-08-04 | 2025-08-07 | ラプタ・セラピューティクス・オーイー | タンパク質ホスファターゼ２ａ（ｐｐ２ａ）モジュレーターとして使用するための芳香族化合物 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4634766A (en) | 1983-10-31 | 1987-01-06 | Merck Frosst Canada, Inc. | 1,4-diaza-phenothiazines |
| GB8510680D0 (en) | 1985-04-26 | 1985-06-05 | Smith Kline French Lab | Pyridine derivatives |
| US4882351A (en) | 1987-10-14 | 1989-11-21 | Roussel Uclaf | Tricyclic compounds |
| ATE225334T1 (de) | 1993-07-26 | 2002-10-15 | Eisai Co Ltd | Sulfonamide und sulfonsäure-ester mit je einem trizyclischen heteroring |
| WO1997030038A1 (en) | 1996-02-15 | 1997-08-21 | Mitsubishi Chemical Corporation | Diarylsultam derivatives |
| US6333322B1 (en) | 1996-03-13 | 2001-12-25 | Eisai Co., Ltd. | Nitrogen-containing tricyclic compounds and drugs containing the same |
| WO1999043683A1 (en) | 1998-02-27 | 1999-09-02 | Eisai Co., Ltd. | Heterocycle-fused benzothiazine derivatives |
| AR031612A1 (es) | 2000-09-20 | 2003-09-24 | Schering Corp | Imidazoles sustituidos, composiciones farmaceuticas, metodo para su preparacion y el uso de los mismos para preparar un medicamento como agonistas o antagonistas h1 y h3 de histamina |
| WO2003066040A1 (en) | 2002-02-05 | 2003-08-14 | Ajinomoto Co.,Inc. | Medicinal compositions containing gabapentin or pregabalin and n-type calcium channel antagonist |
| TW200400816A (en) | 2002-06-26 | 2004-01-16 | Lilly Co Eli | Tricyclic steroid hormone nuclear receptor modulators |
| CN101084209A (zh) | 2004-12-21 | 2007-12-05 | 德福根有限公司 | 具有Kv4离子通道活性的化合物 |
| IT1362675B (it) | 2005-03-15 | 2009-06-25 | Menarini Internat Operations Luxembourg Sa | N-idrossiammidi -sostituiti con gruppi triciclici come inibitori dell'istone deacelitasi,loro preparazione ed impiego in formulazioni farmaceutiche |
| BRPI0608469A2 (pt) | 2005-04-22 | 2010-01-05 | Alantos Pharmaceuticals Holding Inc | inibidores de dipeptidil peptidase-iv |
| GB0508992D0 (en) | 2005-05-03 | 2005-06-08 | Novartis Ag | Organic compounds |
| CL2007003244A1 (es) | 2006-11-16 | 2008-04-04 | Millennium Pharm Inc | Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer. |
| WO2008121859A1 (en) | 2007-03-30 | 2008-10-09 | Xenon Pharmaceuticals Inc. | Methods of using tricyclic compounds in treating sodium channel-mediated diseases or conditions |
| HK1198384A1 (en) * | 2011-08-16 | 2015-04-17 | Mt. Sinai School Of Medicine | Tricyclic compounds as anticancer agents |
| WO2014031986A1 (en) | 2012-08-24 | 2014-02-27 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
| CN102942562B (zh) | 2012-12-05 | 2014-10-01 | 天津市斯芬克司药物研发有限公司 | 一种苯并咪唑衍生物及其制备方法和应用 |
| RU2015139700A (ru) * | 2013-02-19 | 2017-03-27 | Икан Скул Оф Медсин Эт Маунт Синай | Трициклические гетероциклические соединения в качестве противораковых средств |
| WO2015138496A1 (en) * | 2014-03-11 | 2015-09-17 | Icahn School Of Medicine At Mount Sinai | Constrained tricyclic sulfonamides |
| US9937186B2 (en) | 2014-03-11 | 2018-04-10 | Icahn School Of Medicine At Mount Sinai | Sulfonamides derived from tricyclyl-2-aminocycloalkanols as anticancer agents |
| CA2994830A1 (en) | 2015-08-06 | 2017-02-09 | Icahn School Of Medicine At Mount Sinai | Stereospecific process for 3-heterocyclylcycloaliphatic-1,2-diols |
| WO2017044571A1 (en) | 2015-09-09 | 2017-03-16 | Icahn School Of Medicine At Mount Sinai | Tricyclic sultam sulfonamides as anticancer and neuroprotective agents |
| WO2017044572A1 (en) | 2015-09-09 | 2017-03-16 | Icahn School Of Medicine At Mount Sinai | Ring constrained diarylamino sulfonamides as anti-cancer agents |
| CA2997784A1 (en) | 2015-09-09 | 2017-03-16 | Icahn School Of Medicine At Mount Sinai | Heterocyclic constrained tricyclic sulfonamides as anti-cancer agents |
| WO2017044575A1 (en) | 2015-09-09 | 2017-03-16 | Icahn School Of Medicine At Mount Sinai | Constrained benzhydryl sulfonamides as anticancer and neuroprotective agents |
-
2016
- 2016-09-08 WO PCT/US2016/050685 patent/WO2017044567A1/en not_active Ceased
- 2016-09-08 US US15/758,038 patent/US10221158B2/en active Active
- 2016-09-08 JP JP2018512944A patent/JP6966425B2/ja not_active Expired - Fee Related
- 2016-09-08 CA CA2997769A patent/CA2997769A1/en not_active Abandoned
- 2016-09-08 EP EP16766784.9A patent/EP3347350A1/en not_active Ceased
- 2016-09-08 CN CN201680063247.5A patent/CN108349943A/zh active Pending
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