JP2012522763A5 - - Google Patents
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- Publication number
- JP2012522763A5 JP2012522763A5 JP2012503350A JP2012503350A JP2012522763A5 JP 2012522763 A5 JP2012522763 A5 JP 2012522763A5 JP 2012503350 A JP2012503350 A JP 2012503350A JP 2012503350 A JP2012503350 A JP 2012503350A JP 2012522763 A5 JP2012522763 A5 JP 2012522763A5
- Authority
- JP
- Japan
- Prior art keywords
- diyl
- alkyl
- group
- alkoxy
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- -1 1,3,4-oxadiazole-2,5-diyl Chemical group 0.000 claims 15
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 239000008186 active pharmaceutical agent Substances 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000003253 isopropoxy group Chemical group [H]C([H])([H])C([H])(O*)C([H])([H])[H] 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 2
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 2
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 1
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims 1
- 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 claims 1
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 1
- YHKWFDPEASWKFQ-UHFFFAOYSA-N 3-nitrobenzene-1,2-diol Chemical class OC1=CC=CC([N+]([O-])=O)=C1O YHKWFDPEASWKFQ-UHFFFAOYSA-N 0.000 claims 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 1
- 125000001931 aliphatic group Chemical group 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000003435 aroyl group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000001589 carboacyl group Chemical group 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 125000002467 phosphate group Chemical class [H]OP(=O)(O[H])O[*] 0.000 claims 1
- 230000004962 physiological condition Effects 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- GBXQPDCOMJJCMJ-UHFFFAOYSA-M trimethyl-[6-(trimethylazaniumyl)hexyl]azanium;bromide Chemical compound [Br-].C[N+](C)(C)CCCCCC[N+](C)(C)C GBXQPDCOMJJCMJ-UHFFFAOYSA-M 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16577809P | 2009-04-01 | 2009-04-01 | |
| US61/165,778 | 2009-04-01 | ||
| PCT/PT2010/000014 WO2010114404A1 (en) | 2009-04-01 | 2010-03-31 | Pharmaceutical formulations comprising nitrocatechol derivatives and methods of making thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015168152A Division JP6239561B2 (ja) | 2009-04-01 | 2015-08-27 | ニトロカテコール誘導体を含む医薬製剤及びその製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012522763A JP2012522763A (ja) | 2012-09-27 |
| JP2012522763A5 true JP2012522763A5 (enExample) | 2013-05-16 |
| JP5864409B2 JP5864409B2 (ja) | 2016-02-17 |
Family
ID=42225014
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012503350A Active JP5864409B2 (ja) | 2009-04-01 | 2010-03-31 | ニトロカテコール誘導体を含む医薬製剤及びその製造方法 |
| JP2015168152A Active JP6239561B2 (ja) | 2009-04-01 | 2015-08-27 | ニトロカテコール誘導体を含む医薬製剤及びその製造方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015168152A Active JP6239561B2 (ja) | 2009-04-01 | 2015-08-27 | ニトロカテコール誘導体を含む医薬製剤及びその製造方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US9132094B2 (enExample) |
| EP (1) | EP2413912B1 (enExample) |
| JP (2) | JP5864409B2 (enExample) |
| KR (4) | KR102329271B1 (enExample) |
| CN (2) | CN102448444B (enExample) |
| AU (1) | AU2010231961B2 (enExample) |
| BR (1) | BRPI1014865B1 (enExample) |
| CA (1) | CA2757411C (enExample) |
| DK (1) | DK2413912T3 (enExample) |
| ES (1) | ES2730678T3 (enExample) |
| MX (1) | MX340360B (enExample) |
| PL (1) | PL2413912T3 (enExample) |
| PT (1) | PT2413912T (enExample) |
| RU (2) | RU2701731C2 (enExample) |
| TR (1) | TR201908590T4 (enExample) |
| WO (1) | WO2010114404A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20022394A1 (it) | 2002-11-13 | 2004-05-14 | Bracco Spa | Uso di triiodotironina 3-solfato come farmaco ad attivita' tireomimetica e relative formulazioni farmaceutiche. |
| ITMI20110713A1 (it) | 2011-04-29 | 2012-10-30 | Bracco Imaging Spa | Processo per la preparazione di un derivato solfatato di3,5-diiodo-o-[3-iodofenil]-l-tirosina |
| US8168793B2 (en) | 2005-07-26 | 2012-05-01 | Portela & Ca., S.A. | Nitrocatechol derivatives as COMT inhibitors |
| EP1845097A1 (en) | 2006-04-10 | 2007-10-17 | Portela & Ca., S.A. | Oxadiazole derivatives as COMT inhibitors |
| PL2481410T3 (pl) | 2007-01-31 | 2017-03-31 | Bial - Portela & Ca., S.A. | Pochodne nitrokatecholu jako inhibitory COMT podawane w określonym schemacie dawkowania |
| CL2009000628A1 (es) | 2008-03-17 | 2010-04-09 | Bial Portela & Companhia S A | Forma cristalina de 5-[3-(2,5-dicloro-4,6-dimetil-1-oxi-piridin-3-il)-[1,2,4]oxadiazol-5-il]-3-nitrobenceno-1,2-diol, composicion farmaceutica que la comprende, proceso para obtenerla y su uso para tratar trastornos del animo, enfermedad de parkinson y trastornos parkinsonianos, alteraciones gastrointestinales, entre otros. |
| US9132094B2 (en) | 2009-04-01 | 2015-09-15 | Bial—Portela & Ca, S.A. | Pharmaceutical formulations comprising nitrocatechol derivatives and methods of making thereof |
| US20140045900A1 (en) * | 2011-02-11 | 2014-02-13 | Bial-Portela & Ca, S.A. | Administration regime for nitrocatechols |
| EP3260443B1 (en) * | 2011-04-08 | 2020-10-07 | Bracco Imaging SPA | A pharmaceutical composition comprising a sulfated derivative of 3,5-diiodo-o-[3-iodophenyl]-l-tyrosine |
| PT2791134T (pt) | 2011-12-13 | 2019-12-18 | BIAL PORTELA & Cª S A | Composto químico útil como intermediário para a preparação de um inibidor de catecol-o-metiltransferase |
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| US12097193B2 (en) | 2018-10-05 | 2024-09-24 | Bial—Portela & Ca, S.A. | Methods for the administration of COMT inhibitors |
| EP3860602A1 (en) | 2018-10-05 | 2021-08-11 | Neurocrine Biosciences, Inc. | Methods for the administration of comt inhibitors |
| EP4117637A1 (en) | 2020-03-13 | 2023-01-18 | Bial-Portela & CA, S.A. | Micronised opicapone |
| TW202200138A (zh) * | 2020-05-26 | 2022-01-01 | 日商小野藥品工業股份有限公司 | 包含奧匹卡朋（ｏｐｉｃａｐｏｎｅ）之錠劑 |
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| GB202016425D0 (en) | 2020-10-16 | 2020-12-02 | Bial Portela & Ca Sa | Treatment regimens for parkinson's disease |
| KR20230118933A (ko) | 2020-12-17 | 2023-08-14 | 바이알 - 포르텔라 앤드 씨에이 에스에이 | 초기 특발성 파킨슨병에 대한 치료 요법 |
| AU2023449890A1 (en) | 2023-05-25 | 2025-11-27 | Bial-Portela & Ca., S.A. | Treatment regimens for early idiopathic parkinson's disease |
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| KR20100083767A (ko) * | 2007-09-19 | 2010-07-22 | 아사히비루 가부시키가이샤 | 한방 엑기스, 생약 엑기스 또는 천연물 추출 엑기스 또는 그러한 혼합물 등의 천연물 유래 물질을 함유 하는 과립물의 제조 방법 및 그 과립물로부터 제조되는 정제의 제조 방법 |
| EP2259777A2 (en) | 2008-02-28 | 2010-12-15 | BIAL - Portela & Ca., S.A. | Pharmaceutical composition for poorly soluble drugs |
| CL2009000628A1 (es) | 2008-03-17 | 2010-04-09 | Bial Portela & Companhia S A | Forma cristalina de 5-[3-(2,5-dicloro-4,6-dimetil-1-oxi-piridin-3-il)-[1,2,4]oxadiazol-5-il]-3-nitrobenceno-1,2-diol, composicion farmaceutica que la comprende, proceso para obtenerla y su uso para tratar trastornos del animo, enfermedad de parkinson y trastornos parkinsonianos, alteraciones gastrointestinales, entre otros. |
| TR201906117T4 (tr) * | 2008-07-29 | 2019-05-21 | Bial Portela & Ca Sa | Nitrokatesollere yönelik uygulama rejimi. |
| US8827197B2 (en) | 2008-11-04 | 2014-09-09 | Microgreen Polymers Inc | Apparatus and method for interleaving polymeric roll for gas impregnation and solid-state foam processing |
| US20100256194A1 (en) | 2009-04-01 | 2010-10-07 | Bial - Portela & Ca, S.A. | Pharmaceutical formulations comprising nitrocatechol derivatives and methods of making the same |
| US9132094B2 (en) | 2009-04-01 | 2015-09-15 | Bial—Portela & Ca, S.A. | Pharmaceutical formulations comprising nitrocatechol derivatives and methods of making thereof |
| CN102781424B (zh) | 2010-03-04 | 2016-03-30 | 奥赖恩公司 | 左旋多巴、卡比多巴和恩他卡朋用于治疗帕金森病的应用 |
| US20140045900A1 (en) | 2011-02-11 | 2014-02-13 | Bial-Portela & Ca, S.A. | Administration regime for nitrocatechols |
| PT2791134T (pt) | 2011-12-13 | 2019-12-18 | BIAL PORTELA & Cª S A | Composto químico útil como intermediário para a preparação de um inibidor de catecol-o-metiltransferase |
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2010
- 2010-03-31 US US12/750,956 patent/US9132094B2/en active Active
- 2010-03-31 KR KR1020187024054A patent/KR102329271B1/ko active Active
- 2010-03-31 PL PL10713380T patent/PL2413912T3/pl unknown
- 2010-03-31 ES ES10713380T patent/ES2730678T3/es active Active
- 2010-03-31 RU RU2016152167A patent/RU2701731C2/ru active
- 2010-03-31 CA CA2757411A patent/CA2757411C/en active Active
- 2010-03-31 KR KR1020177009828A patent/KR102023255B1/ko active Active
- 2010-03-31 CN CN201080022653.XA patent/CN102448444B/zh active Active
- 2010-03-31 MX MX2011010415A patent/MX340360B/es active IP Right Grant
- 2010-03-31 DK DK10713380.3T patent/DK2413912T3/da active
- 2010-03-31 KR KR20117026011A patent/KR20120027197A/ko not_active Ceased
- 2010-03-31 RU RU2011144145/15A patent/RU2011144145A/ru not_active Application Discontinuation
- 2010-03-31 WO PCT/PT2010/000014 patent/WO2010114404A1/en not_active Ceased
- 2010-03-31 BR BRPI1014865-5A patent/BRPI1014865B1/pt active IP Right Grant
- 2010-03-31 KR KR1020217001609A patent/KR20210009441A/ko not_active Ceased
- 2010-03-31 EP EP10713380.3A patent/EP2413912B1/en active Active
- 2010-03-31 CN CN201610250582.8A patent/CN105878242A/zh active Pending
- 2010-03-31 JP JP2012503350A patent/JP5864409B2/ja active Active
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2015
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2024
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