JP2009503112A5 - - Google Patents
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- Publication number
- JP2009503112A5 JP2009503112A5 JP2008525240A JP2008525240A JP2009503112A5 JP 2009503112 A5 JP2009503112 A5 JP 2009503112A5 JP 2008525240 A JP2008525240 A JP 2008525240A JP 2008525240 A JP2008525240 A JP 2008525240A JP 2009503112 A5 JP2009503112 A5 JP 2009503112A5
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- Prior art keywords
- optionally substituted
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- compound
- phenyl
- linear
- Prior art date
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- 150000001875 compounds Chemical class 0.000 claims 23
- -1 4-t-butylphenyl Chemical group 0.000 claims 17
- 229910052760 oxygen Inorganic materials 0.000 claims 15
- 229910052717 sulfur Inorganic materials 0.000 claims 15
- 125000000217 alkyl group Chemical group 0.000 claims 13
- 125000002950 monocyclic group Chemical group 0.000 claims 13
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 13
- 150000003839 salts Chemical class 0.000 claims 13
- 230000003381 solubilizing effect Effects 0.000 claims 13
- RWRIWBAIICGTTQ-UHFFFAOYSA-N difluoromethane Chemical compound FCF RWRIWBAIICGTTQ-UHFFFAOYSA-N 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 8
- 125000004076 pyridyl group Chemical group 0.000 claims 7
- 125000002541 furyl group Chemical group 0.000 claims 5
- 125000003226 pyrazolyl group Chemical group 0.000 claims 5
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 5
- 125000001544 thienyl group Chemical group 0.000 claims 5
- 125000004801 4-cyanophenyl group Chemical group [H]C1=C([H])C(C#N)=C([H])C([H])=C1* 0.000 claims 4
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims 4
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 3
- 125000001624 naphthyl group Chemical group 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 125000003373 pyrazinyl group Chemical group 0.000 claims 3
- 206010022489 Insulin Resistance Diseases 0.000 claims 2
- 125000004618 benzofuryl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims 2
- 239000000651 prodrug Substances 0.000 claims 2
- 229940002612 prodrug Drugs 0.000 claims 2
- 239000002510 pyrogen Substances 0.000 claims 2
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 2
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 claims 2
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 claims 1
- 125000003762 3,4-dimethoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000000319 biphenyl-4-yl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000000040 m-tolyl group Chemical group [H]C1=C([H])C(*)=C([H])C(=C1[H])C([H])([H])[H] 0.000 claims 1
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
- 0 C*c1nnc(C)[o]1 Chemical compound C*c1nnc(C)[o]1 0.000 description 8
- HGCIXCUEYOPUTN-UHFFFAOYSA-N C1CC=CCC1 Chemical compound C1CC=CCC1 HGCIXCUEYOPUTN-UHFFFAOYSA-N 0.000 description 1
- UAEPNZWRGJTJPN-UHFFFAOYSA-N CC1CCCCC1 Chemical compound CC1CCCCC1 UAEPNZWRGJTJPN-UHFFFAOYSA-N 0.000 description 1
- JFMQEVNIDXHTSG-UHFFFAOYSA-N Ic1cc2n[o]nc2cc1 Chemical compound Ic1cc2n[o]nc2cc1 JFMQEVNIDXHTSG-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70561205P | 2005-08-04 | 2005-08-04 | |
| US60/705,612 | 2005-08-04 | ||
| US74178305P | 2005-12-02 | 2005-12-02 | |
| US60/741,783 | 2005-12-02 | ||
| US77937006P | 2006-03-03 | 2006-03-03 | |
| US60/779,370 | 2006-03-03 | ||
| US79227606P | 2006-04-14 | 2006-04-14 | |
| US60/792,276 | 2006-04-14 | ||
| PCT/US2006/030510 WO2007019344A1 (en) | 2005-08-04 | 2006-08-04 | Imidazo [2,1-b] thiayole derivatives as sirtuin modulating compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012125926A Division JP2012214480A (ja) | 2005-08-04 | 2012-06-01 | サーチュイン調節化合物としてのイミダゾ［２，１−ｂ］チアゾール誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009503112A JP2009503112A (ja) | 2009-01-29 |
| JP2009503112A5 true JP2009503112A5 (enExample) | 2009-09-17 |
| JP5203193B2 JP5203193B2 (ja) | 2013-06-05 |
Family
ID=37074951
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008525242A Expired - Fee Related JP5203195B2 (ja) | 2005-08-04 | 2006-08-04 | サーチュインモジュレーターとしてのベンゾチアゾールおよびチアゾロピリジン |
| JP2008525241A Expired - Fee Related JP5203194B2 (ja) | 2005-08-04 | 2006-08-04 | サーチュイン調節因子としてのイミダゾピリジン誘導体 |
| JP2008525273A Expired - Fee Related JP5203196B2 (ja) | 2005-08-04 | 2006-08-04 | サーチュインモジュレーターとしてのオキサゾロピリジン誘導体 |
| JP2008525240A Expired - Fee Related JP5203193B2 (ja) | 2005-08-04 | 2006-08-04 | サーチュイン調節化合物としてのイミダゾ［２，１−ｂ］チアゾール誘導体 |
| JP2008525272A Pending JP2009503117A (ja) | 2005-08-04 | 2006-08-04 | サーチュインモジュレーターとしてのベンゾイミダゾール誘導体 |
| JP2012126044A Withdrawn JP2012211149A (ja) | 2005-08-04 | 2012-06-01 | サーチュインモジュレーターとしてのベンゾチアゾールおよびチアゾロピリジン |
| JP2012125926A Withdrawn JP2012214480A (ja) | 2005-08-04 | 2012-06-01 | サーチュイン調節化合物としてのイミダゾ［２，１−ｂ］チアゾール誘導体 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008525242A Expired - Fee Related JP5203195B2 (ja) | 2005-08-04 | 2006-08-04 | サーチュインモジュレーターとしてのベンゾチアゾールおよびチアゾロピリジン |
| JP2008525241A Expired - Fee Related JP5203194B2 (ja) | 2005-08-04 | 2006-08-04 | サーチュイン調節因子としてのイミダゾピリジン誘導体 |
| JP2008525273A Expired - Fee Related JP5203196B2 (ja) | 2005-08-04 | 2006-08-04 | サーチュインモジュレーターとしてのオキサゾロピリジン誘導体 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008525272A Pending JP2009503117A (ja) | 2005-08-04 | 2006-08-04 | サーチュインモジュレーターとしてのベンゾイミダゾール誘導体 |
| JP2012126044A Withdrawn JP2012211149A (ja) | 2005-08-04 | 2012-06-01 | サーチュインモジュレーターとしてのベンゾチアゾールおよびチアゾロピリジン |
| JP2012125926A Withdrawn JP2012214480A (ja) | 2005-08-04 | 2012-06-01 | サーチュイン調節化合物としてのイミダゾ［２，１−ｂ］チアゾール誘導体 |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US20070037865A1 (enExample) |
| EP (7) | EP2388263A1 (enExample) |
| JP (7) | JP5203195B2 (enExample) |
| CN (1) | CN103145738A (enExample) |
| AU (5) | AU2006278396A1 (enExample) |
| CA (5) | CA2617557A1 (enExample) |
| DK (1) | DK1910384T3 (enExample) |
| ES (3) | ES2397275T3 (enExample) |
| PL (1) | PL1910384T3 (enExample) |
| PT (1) | PT1910384E (enExample) |
| WO (5) | WO2007019416A1 (enExample) |
Families Citing this family (232)
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| US11207518B2 (en) * | 2004-12-27 | 2021-12-28 | The Feinstein Institutes For Medical Research | Treating inflammatory disorders by stimulation of the cholinergic anti-inflammatory pathway |
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-
2006
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- 2006-08-04 WO PCT/US2006/030660 patent/WO2007019416A1/en not_active Ceased
- 2006-08-04 EP EP11075196A patent/EP2388263A1/en not_active Withdrawn
- 2006-08-04 CA CA002618368A patent/CA2618368A1/en not_active Abandoned
- 2006-08-04 CN CN2013100565553A patent/CN103145738A/zh active Pending
- 2006-08-04 EP EP06789431A patent/EP1910384B1/en not_active Not-in-force
- 2006-08-04 JP JP2008525242A patent/JP5203195B2/ja not_active Expired - Fee Related
- 2006-08-04 DK DK06789431.1T patent/DK1910384T3/da active
- 2006-08-04 ES ES06789432T patent/ES2397275T3/es active Active
- 2006-08-04 AU AU2006278396A patent/AU2006278396A1/en not_active Abandoned
- 2006-08-04 AU AU2006278504A patent/AU2006278504B2/en not_active Ceased
- 2006-08-04 EP EP06789432A patent/EP1910362B9/en not_active Not-in-force
- 2006-08-04 US US11/499,919 patent/US7345178B2/en not_active Expired - Fee Related
- 2006-08-04 CA CA2618360A patent/CA2618360C/en not_active Expired - Fee Related
- 2006-08-04 PL PL06789431T patent/PL1910384T3/pl unknown
- 2006-08-04 AU AU2006278503A patent/AU2006278503B2/en not_active Ceased
- 2006-08-04 WO PCT/US2006/030510 patent/WO2007019344A1/en not_active Ceased
- 2006-08-04 ES ES06789431T patent/ES2396913T3/es active Active
- 2006-08-04 JP JP2008525241A patent/JP5203194B2/ja not_active Expired - Fee Related
- 2006-08-04 JP JP2008525273A patent/JP5203196B2/ja not_active Expired - Fee Related
- 2006-08-04 EP EP06789500A patent/EP1909910A1/en not_active Withdrawn
- 2006-08-04 JP JP2008525240A patent/JP5203193B2/ja not_active Expired - Fee Related
- 2006-08-04 AU AU2006278397A patent/AU2006278397B2/en not_active Expired - Fee Related
- 2006-08-04 WO PCT/US2006/030512 patent/WO2007019346A1/en not_active Ceased
- 2006-08-04 EP EP11007255A patent/EP2468752A1/en not_active Withdrawn
- 2006-08-04 EP EP06789433.7A patent/EP1910385B1/en not_active Not-in-force
- 2006-08-04 CA CA002618370A patent/CA2618370A1/en not_active Abandoned
- 2006-08-04 ES ES06789433T patent/ES2431050T3/es active Active
- 2006-08-04 CA CA002617532A patent/CA2617532A1/en not_active Abandoned
- 2006-08-04 WO PCT/US2006/030511 patent/WO2007019345A1/en not_active Ceased
- 2006-08-04 PT PT67894311T patent/PT1910384E/pt unknown
- 2006-08-04 AU AU2006278505A patent/AU2006278505B2/en not_active Ceased
- 2006-08-04 EP EP06800850A patent/EP1910380A1/en not_active Withdrawn
- 2006-08-04 WO PCT/US2006/030661 patent/WO2007019417A1/en not_active Ceased
- 2006-08-04 JP JP2008525272A patent/JP2009503117A/ja active Pending
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2008
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