ES2134481T3 - Metodo y aparato para producir microconjuntos de muestras biologicas. - Google Patents

Metodo y aparato para producir microconjuntos de muestras biologicas.

Info

Publication number
ES2134481T3
ES2134481T3 ES95923921T ES95923921T ES2134481T3 ES 2134481 T3 ES2134481 T3 ES 2134481T3 ES 95923921 T ES95923921 T ES 95923921T ES 95923921 T ES95923921 T ES 95923921T ES 2134481 T3 ES2134481 T3 ES 2134481T3
Authority
ES
Spain
Prior art keywords
assemblies
biological samples
producing micro
micro
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95923921T
Other languages
English (en)
Other versions
ES2134481T5 (es
Inventor
Tidhar Dari Shalon
Patrick O Brown
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leland Stanford Junior University
Original Assignee
Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26948575&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2134481(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Leland Stanford Junior University filed Critical Leland Stanford Junior University
Application granted granted Critical
Publication of ES2134481T3 publication Critical patent/ES2134481T3/es
Publication of ES2134481T5 publication Critical patent/ES2134481T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0244—Drop counters; Drop formers using pins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J4/00—Feed or outlet devices; Feed or outlet control devices
    • B01J4/02—Feed or outlet devices; Feed or outlet control devices for feeding measured, i.e. prescribed quantities of reagents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0244—Drop counters; Drop formers using pins
    • B01L3/0248—Prongs, quill pen type dispenser
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0268—Drop counters; Drop formers using pulse dispensing or spraying, eg. inkjet type, piezo actuated ejection of droplets from capillaries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5088—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above confining liquids at a location by surface tension, e.g. virtual wells on plates, wires
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00364—Pipettes
    • B01J2219/00367—Pipettes capillary
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00378—Piezoelectric or ink jet dispensers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00457—Dispensing or evacuation of the solid phase support
    • B01J2219/00475—Sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/0059—Sequential processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/0061—The surface being organic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00617—Delimitation of the attachment areas by chemical means
    • B01J2219/00619—Delimitation of the attachment areas by chemical means using hydrophilic or hydrophobic regions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00621—Delimitation of the attachment areas by physical means, e.g. trenches, raised areas
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/00626—Covalent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/0063—Other, e.g. van der Waals forces, hydrogen bonding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
    • B01J2219/00641—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being continuous, e.g. porous oxide substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B01J2219/00689—Automatic using computers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
    • G01N2001/282—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on with mapping; Identification of areas; Spatial correlated pattern
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178—Special arrangements of analysers
    • G01N2035/00237—Handling microquantities of analyte, e.g. microvalves, capillary networks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1034—Transferring microquantities of liquid
    • G01N2035/1037—Using surface tension, e.g. pins or wires
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/115831—Condition or time responsive
    • Y10T436/116664—Condition or time responsive with automated titrator

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Clinical Laboratory Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Wing Frames And Configurations (AREA)
  • Hinges (AREA)

Abstract

SE PRESENTAN UN METODO Y UN APARATO PARA LA FORMACION DE MICROMATRICES DE MUESTRAS BIOLOGICAS SOBRE UN SOPORTE. EL METODO CONSISTE EN DISTRIBUIR UN VOLUMEN CONOCIDO DE UN REACTIVO EN CADA POSICION SELECCIONADA DE UNA MATRIZ, MEDIANTE LA PUNCION DE UN DISTRIBUIDOR CAPILAR SOBRE EL SOPORTE BAJO CONDICIONES EFECTIVAS COMO PARA EXTRAER UN VOLUMEN DE LIQUIDO DETERMINADO DEL SOPORTE. EL APARATO ESTA DISEÑADO PARA PRODUCIR UNA MICROMATRIZ DE TALES REGIONES DE FORMA AUTOMATIZADA.
ES95923921T 1994-06-17 1995-06-16 Método y aparato para producir microconjuntos de muestras biológicas Expired - Lifetime ES2134481T5 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US26138894A 1994-06-17 1994-06-17
US261388 1994-06-17
US477809 1995-06-07
US08/477,809 US5807522A (en) 1994-06-17 1995-06-07 Methods for fabricating microarrays of biological samples
PCT/US1995/007659 WO1995035505A1 (en) 1994-06-17 1995-06-16 Method and apparatus for fabricating microarrays of biological samples

Publications (2)

Publication Number Publication Date
ES2134481T3 true ES2134481T3 (es) 1999-10-01
ES2134481T5 ES2134481T5 (es) 2012-06-25

Family

ID=26948575

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95923921T Expired - Lifetime ES2134481T5 (es) 1994-06-17 1995-06-16 Método y aparato para producir microconjuntos de muestras biológicas

Country Status (11)

Country Link
US (2) US5807522A (es)
EP (2) EP0804731B2 (es)
JP (2) JP3272365B2 (es)
AT (1) ATE180570T1 (es)
AU (1) AU709276B2 (es)
CA (2) CA2192095C (es)
DE (1) DE69509925T3 (es)
DK (1) DK0804731T4 (es)
ES (1) ES2134481T5 (es)
GR (1) GR3030430T3 (es)
WO (1) WO1995035505A1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110650688A (zh) * 2017-05-19 2020-01-03 蒂达尔·沙隆 用于收集胃肠道样本的装置和方法

Families Citing this family (1398)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6054270A (en) * 1988-05-03 2000-04-25 Oxford Gene Technology Limited Analying polynucleotide sequences
US6346413B1 (en) 1989-06-07 2002-02-12 Affymetrix, Inc. Polymer arrays
US6379895B1 (en) 1989-06-07 2002-04-30 Affymetrix, Inc. Photolithographic and other means for manufacturing arrays
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US6551784B2 (en) 1989-06-07 2003-04-22 Affymetrix Inc Method of comparing nucleic acid sequences
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5547839A (en) * 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US6406844B1 (en) 1989-06-07 2002-06-18 Affymetrix, Inc. Very large scale immobilized polymer synthesis
US6309822B1 (en) * 1989-06-07 2001-10-30 Affymetrix, Inc. Method for comparing copy number of nucleic acid sequences
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US6506558B1 (en) 1990-03-07 2003-01-14 Affymetrix Inc. Very large scale immobilized polymer synthesis
DK0834575T3 (da) 1990-12-06 2002-04-02 Affymetrix Inc A Delaware Corp Identifikation af nucleinsyrer i prøver
US6943034B1 (en) 1991-11-22 2005-09-13 Affymetrix, Inc. Combinatorial strategies for polymer synthesis
ATE241426T1 (de) * 1991-11-22 2003-06-15 Affymetrix Inc A Delaware Corp Verfahren zur herstellung von polymerarrays
US6468740B1 (en) 1992-11-05 2002-10-22 Affymetrix, Inc. Cyclic and substituted immobilized molecular synthesis
US5795714A (en) * 1992-11-06 1998-08-18 Trustees Of Boston University Method for replicating an array of nucleic acid probes
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
DE4344726C2 (de) * 1993-12-27 1997-09-25 Deutsches Krebsforsch Verfahren zum Nachweis von nicht balanciertem genetischen Material einer Spezies oder zum Nachweis der Genexpression in Zellen einer Spezies
US6287850B1 (en) * 1995-06-07 2001-09-11 Affymetrix, Inc. Bioarray chip reaction apparatus and its manufacture
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US7615368B1 (en) 1994-06-17 2009-11-10 The Board Of Trustees Of The Leland Stanford Junior University Microarrays of polypeptides
US7323298B1 (en) * 1994-06-17 2008-01-29 The Board Of Trustees Of The Leland Stanford Junior University Microarray for determining the relative abundances of polynuceotide sequences
GB9418981D0 (en) * 1994-09-21 1994-11-09 Univ Glasgow Apparatus and method for carrying out analysis of samples
USRE43097E1 (en) 1994-10-13 2012-01-10 Illumina, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
US6121048A (en) * 1994-10-18 2000-09-19 Zaffaroni; Alejandro C. Method of conducting a plurality of reactions
US5795716A (en) 1994-10-21 1998-08-18 Chee; Mark S. Computer-aided visualization and analysis system for sequence evaluation
US8236493B2 (en) 1994-10-21 2012-08-07 Affymetrix, Inc. Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
SE9404166D0 (sv) * 1994-11-30 1994-11-30 Pharmacia Biotech Ab Multifunctional surfaces
US5830645A (en) * 1994-12-09 1998-11-03 The Regents Of The University Of California Comparative fluorescence hybridization to nucleic acid arrays
US6428955B1 (en) 1995-03-17 2002-08-06 Sequenom, Inc. DNA diagnostics based on mass spectrometry
US7803529B1 (en) 1995-04-11 2010-09-28 Sequenom, Inc. Solid phase sequencing of biopolymers
US5830655A (en) 1995-05-22 1998-11-03 Sri International Oligonucleotide sizing using cleavable primers
US5690894A (en) * 1995-05-23 1997-11-25 The Regents Of The University Of California High density array fabrication and readout method for a fiber optic biosensor
US6720149B1 (en) * 1995-06-07 2004-04-13 Affymetrix, Inc. Methods for concurrently processing multiple biological chip assays
US6660233B1 (en) * 1996-01-16 2003-12-09 Beckman Coulter, Inc. Analytical biochemistry system with robotically carried bioarray
US6864059B2 (en) 1996-01-23 2005-03-08 Affymetrix, Inc. Biotin containing C-glycoside nucleic acid labeling compounds
US20010018514A1 (en) 1998-07-31 2001-08-30 Mcgall Glenn H. Nucleic acid labeling compounds
US7282327B2 (en) 1996-01-23 2007-10-16 Affymetrix, Inc. Nucleic acid labeling compounds
US6965020B2 (en) 1996-01-23 2005-11-15 Affymetrix, Inc. Nucleic acid labeling compounds
US7423143B2 (en) 1996-01-23 2008-09-09 Affymetrix. Inc. Nucleic acid labeling compounds
EP0880598A4 (en) 1996-01-23 2005-02-23 Affymetrix Inc RAPID EVALUATION OF NUCLEIC ACID ABUNDANCE DIFFERENCE, WITH A HIGH-DENSITY OLIGONUCLEOTIDE SYSTEM
US7291463B2 (en) 1996-01-23 2007-11-06 Affymetrix, Inc. Nucleic acid labeling compounds
US5837196A (en) * 1996-01-26 1998-11-17 The Regents Of The University Of California High density array fabrication and readout method for a fiber optic biosensor
EP0886681A1 (en) 1996-03-04 1998-12-30 Genetrace Systems, Inc. Methods of screening nucleic acids using mass spectrometry
US6881571B1 (en) * 1998-03-11 2005-04-19 Exonhit Therapeutics S.A. Qualitative differential screening
US6361937B1 (en) 1996-03-19 2002-03-26 Affymetrix, Incorporated Computer-aided nucleic acid sequencing
US7244622B2 (en) * 1996-04-03 2007-07-17 Applera Corporation Device and method for multiple analyte detection
US6586193B2 (en) * 1996-04-25 2003-07-01 Genicon Sciences Corporation Analyte assay using particulate labels
US5958342A (en) * 1996-05-17 1999-09-28 Incyte Pharmaceuticals, Inc. Jet droplet device
US5770151A (en) * 1996-06-05 1998-06-23 Molecular Dynamics, Inc. High-speed liquid deposition device for biological molecule array formation
DE19628928A1 (de) 1996-07-18 1998-01-22 Basf Ag Feste Träger für analytische Meßverfahren, ein Verfahren zu ihrer Herstellung sowie ihre Verwendung
US6582921B2 (en) * 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
US5777324A (en) * 1996-09-19 1998-07-07 Sequenom, Inc. Method and apparatus for maldi analysis
US5965363A (en) 1996-09-19 1999-10-12 Genetrace Systems Inc. Methods of preparing nucleic acids for mass spectrometric analysis
US6391550B1 (en) * 1996-09-19 2002-05-21 Affymetrix, Inc. Identification of molecular sequence signatures and methods involving the same
CA2266745A1 (en) * 1996-09-19 1998-03-26 Affymetrix, Inc. Identification of molecular sequence signatures and methods involving the same
US6124092A (en) * 1996-10-04 2000-09-26 The Perkin-Elmer Corporation Multiplex polynucleotide capture methods and compositions
GB9622665D0 (en) * 1996-10-31 1997-01-08 Zeneca Ltd Methods
AU761161B2 (en) * 1996-11-06 2003-05-29 Sequenom, Inc. High density immobilization of nucleic acids
EP0937096B1 (en) 1996-11-06 2004-02-04 Sequenom, Inc. Method of mass spectrometry analysis
AU745624B2 (en) * 1996-11-06 2002-03-28 Sequenom, Inc. High density immobilization of nucleic acids
US6024925A (en) * 1997-01-23 2000-02-15 Sequenom, Inc. Systems and methods for preparing low volume analyte array elements
US7285422B1 (en) * 1997-01-23 2007-10-23 Sequenom, Inc. Systems and methods for preparing and analyzing low volume analyte array elements
US6699719B2 (en) * 1996-11-29 2004-03-02 Proteomic Systems, Inc. Biosensor arrays and methods
US6503452B1 (en) * 1996-11-29 2003-01-07 The Board Of Trustees Of The Leland Stanford Junior University Biosensor arrays and methods
US6083761A (en) * 1996-12-02 2000-07-04 Glaxo Wellcome Inc. Method and apparatus for transferring and combining reagents
US6054325A (en) * 1996-12-02 2000-04-25 Glaxo Wellcom Inc. Method and apparatus for transferring and combining distinct chemical compositions with reagents
CA2274587A1 (en) 1996-12-10 1998-06-18 Genetrace Systems Inc. Releasable nonvolatile mass-label molecules
US6060240A (en) * 1996-12-13 2000-05-09 Arcaris, Inc. Methods for measuring relative amounts of nucleic acids in a complex mixture and retrieval of specific sequences therefrom
WO1998029736A1 (en) 1996-12-31 1998-07-09 Genometrix Incorporated Multiplexed molecular analysis apparatus and method
US6303301B1 (en) * 1997-01-13 2001-10-16 Affymetrix, Inc. Expression monitoring for gene function identification
US6309824B1 (en) * 1997-01-16 2001-10-30 Hyseq, Inc. Methods for analyzing a target nucleic acid using immobilized heterogeneous mixtures of oligonucleotide probes
DE19707204A1 (de) * 1997-02-24 1998-08-27 Boehringer Mannheim Gmbh System zur Herstellung diagnostischer Vielfach-Testelemente
US6553317B1 (en) * 1997-03-05 2003-04-22 Incyte Pharmaceuticals, Inc. Relational database and system for storing information relating to biomolecular sequences and reagents
EP0970101A2 (en) 1997-03-20 2000-01-12 University Of Washington Solvent for biopolymer synthesis, solvent microdroplets and methods of use
US6028189A (en) * 1997-03-20 2000-02-22 University Of Washington Solvent for oligonucleotide synthesis and methods of use
US6419883B1 (en) 1998-01-16 2002-07-16 University Of Washington Chemical synthesis using solvent microdroplets
CA2291180A1 (en) 1997-05-23 1998-11-26 Lynx Therapeutics, Inc. System and apparatus for sequential processing of analytes
ATE367203T1 (de) * 1997-06-02 2007-08-15 Aurora Discovery Inc Mehrgefässplatten mit kleiner störstrahlung für fluoreszenzmessungen von biologischen und biochemischen proben
JP3120453B2 (ja) * 1997-06-19 2000-12-25 トヨタ自動車株式会社 微小液滴の保持方法、反応方法
NZ516848A (en) 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
AU8177398A (en) * 1997-06-30 1999-01-19 Government of the United States of America, as represented by The Secretary of the Department of Health and Human Services and His Successors, The Spectral cloning-a new technical approach to the cloning and characterization ofevery chromosomal aberration in cancer samples
CA2297661A1 (en) 1997-07-22 1999-02-04 Darwin Molecular Corp. Amplification and other enzymatic reactions performed on nucleic acid arrays
EP0996500A1 (en) 1997-07-22 2000-05-03 Rapigene, Inc. Apparatus and methods for arraying solution onto a solid support
EP1000176A1 (en) 1997-07-22 2000-05-17 Rapigene, Inc. Computer method and system for correlating sequencing data by ms
JP4313861B2 (ja) 1997-08-01 2009-08-12 キヤノン株式会社 プローブアレイの製造方法
US6548020B2 (en) * 1997-08-01 2003-04-15 Canon Kabushiki Kaisha Reaction site array with a black matrix to decrease cross-contamination between reaction regions
US6432639B1 (en) 1997-09-10 2002-08-13 Dna Sciences Laboratories, Inc. Isolated CYP3A4 nucleic acid molecules and detection methods
US7745142B2 (en) 1997-09-15 2010-06-29 Molecular Devices Corporation Molecular modification assays
US6013486A (en) * 1997-09-17 2000-01-11 Yale University Method for selection of insertion mutants
US7214298B2 (en) * 1997-09-23 2007-05-08 California Institute Of Technology Microfabricated cell sorter
DE19742246A1 (de) * 1997-09-25 1999-04-01 Basf Ag Analytisches Meßverfahren und seine Verwendung
US6762019B2 (en) * 1997-09-30 2004-07-13 Surmodics, Inc. Epoxide polymer surfaces
US6465178B2 (en) * 1997-09-30 2002-10-15 Surmodics, Inc. Target molecule attachment to surfaces
US7351578B2 (en) 1999-12-10 2008-04-01 Invitrogen Corp. Use of multiple recombination sites with unique specificity in recombinational cloning
US7157234B2 (en) * 1997-10-24 2007-01-02 Beckman Coulter, Inc. Detection of very low quantities of analyte bound to a solid phase
CA2307141C (en) * 1997-10-31 2004-01-27 The Perkin-Elmer Corporation Method and apparatus for making arrays
US7321023B2 (en) * 1997-11-07 2008-01-22 Incyte Corporation SP16 protein
US5922617A (en) * 1997-11-12 1999-07-13 Functional Genetics, Inc. Rapid screening assay methods and devices
US6177558B1 (en) * 1997-11-13 2001-01-23 Protogene Laboratories, Inc. Method and composition for chemical synthesis using high boiling point organic solvents to control evaporation
US6101946A (en) * 1997-11-21 2000-08-15 Telechem International Inc. Microarray printing device including printing pins with flat tips and exterior channel and method of manufacture
US6268131B1 (en) 1997-12-15 2001-07-31 Sequenom, Inc. Mass spectrometric methods for sequencing nucleic acids
US5957167A (en) * 1997-12-18 1999-09-28 Pharmacopeia, Inc. Article for dispensing small volumes of liquid
US20030096232A1 (en) * 1997-12-19 2003-05-22 Kris Richard M. High throughput assay system
US6232066B1 (en) * 1997-12-19 2001-05-15 Neogen, Inc. High throughput assay system
US20100105572A1 (en) * 1997-12-19 2010-04-29 Kris Richard M High throughput assay system
US20030039967A1 (en) * 1997-12-19 2003-02-27 Kris Richard M. High throughput assay system using mass spectrometry
US6087102A (en) 1998-01-07 2000-07-11 Clontech Laboratories, Inc. Polymeric arrays and methods for their use in binding assays
US7470547B2 (en) * 2003-07-31 2008-12-30 Biodot, Inc. Methods and systems for dispensing sub-microfluidic drops
US20020159919A1 (en) * 1998-01-09 2002-10-31 Carl Churchill Method and apparatus for high-speed microfluidic dispensing using text file control
US6265163B1 (en) 1998-01-09 2001-07-24 Lynx Therapeutics, Inc. Solid phase selection of differentially expressed genes
US6063339A (en) * 1998-01-09 2000-05-16 Cartesian Technologies, Inc. Method and apparatus for high-speed dot array dispensing
WO1999034920A1 (en) * 1998-01-12 1999-07-15 Massachusetts Institute Of Technology Method and apparatus for performing microassays
US6893877B2 (en) 1998-01-12 2005-05-17 Massachusetts Institute Of Technology Methods for screening substances in a microwell array
US6428752B1 (en) 1998-05-14 2002-08-06 Affymetrix, Inc. Cleaning deposit devices that form microarrays and the like
US6407858B1 (en) 1998-05-14 2002-06-18 Genetic Microsystems, Inc Focusing of microscopes and reading of microarrays
US6269846B1 (en) 1998-01-13 2001-08-07 Genetic Microsystems, Inc. Depositing fluid specimens on substrates, resulting ordered arrays, techniques for deposition of arrays
US6722395B2 (en) 1998-01-13 2004-04-20 James W. Overbeck Depositing fluid specimens on substrates, resulting ordered arrays, techniques for analysis of deposited arrays
JP2002500896A (ja) * 1998-01-26 2002-01-15 ジェンザイム・コーポレーション 治療標的の同定法
US6297010B1 (en) 1998-01-30 2001-10-02 Genzyme Corporation Method for detecting and identifying mutations
ATE393912T1 (de) 1998-02-04 2008-05-15 Invitrogen Corp Microarrays und ihre verwendungen
US6537505B1 (en) 1998-02-20 2003-03-25 Bio Dot, Inc. Reagent dispensing valve
GB9803684D0 (en) * 1998-02-24 1998-04-15 Genevac Ltd Method and apparatus for controlling temperature during evaporation of samples
US20020090639A1 (en) * 1998-02-26 2002-07-11 Mcginnis Ralph Evan Two dimensional linkage study methods and related inventions
US6610526B2 (en) * 1998-03-13 2003-08-26 Inctye Corporation Human E1-like protein
US7095032B2 (en) * 1998-03-20 2006-08-22 Montagu Jean I Focusing of microscopes and reading of microarrays
FR2776389B1 (fr) * 1998-03-20 2000-06-16 Fondation Jean Dausset Ceph Dispositif automatique de realisation d'echantillons en vue de la mise en oeuvre de reactions chimiques ou biologiques en milieu liquide
US6218114B1 (en) * 1998-03-27 2001-04-17 Academia Sinica Methods for detecting differentially expressed genes
US6077673A (en) * 1998-03-31 2000-06-20 Clontech Laboratories, Inc. Mouse arrays and kits comprising the same
US6350618B1 (en) 1998-04-27 2002-02-26 Corning Incorporated Redrawn capillary imaging reservoir
DE69835342T2 (de) * 1998-04-27 2007-08-23 Corning Inc. Verfahren zur Ablage von biologischen Proben mit Hilfe eines nachgezogenen Kapillarspeichers
US6884626B1 (en) 1998-04-27 2005-04-26 Corning Incorporated Redrawn capillary imaging reservoir
US6048695A (en) * 1998-05-04 2000-04-11 Baylor College Of Medicine Chemically modified nucleic acids and methods for coupling nucleic acids to solid support
US6723564B2 (en) 1998-05-07 2004-04-20 Sequenom, Inc. IR MALDI mass spectrometry of nucleic acids using liquid matrices
DE19823660C1 (de) * 1998-05-20 1999-10-07 Nanomont Ges Fuer Nanotechnolo Verfahren und Vorrichtung zur Fixierung fester Mikro- und/oder Nanoobjekte
US6268210B1 (en) * 1998-05-27 2001-07-31 Hyseq, Inc. Sandwich arrays of biological compounds
EP2360271A1 (en) 1998-06-24 2011-08-24 Illumina, Inc. Decoding of array sensors with microspheres
CA2331386A1 (en) 1998-06-26 2000-01-06 Incyte Pharmaceuticals, Inc. Human signal peptide-containing proteins
US6762061B1 (en) 1998-07-03 2004-07-13 Corning Incorporated Redrawn capillary imaging reservoir
CN1315913A (zh) * 1998-07-07 2001-10-03 笛卡尔技术公司 用于微量液体移液的管尖设计和随机存取系统
US6551557B1 (en) 1998-07-07 2003-04-22 Cartesian Technologies, Inc. Tip design and random access array for microfluidic transfer
US6406921B1 (en) 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US6897073B2 (en) 1998-07-14 2005-05-24 Zyomyx, Inc. Non-specific binding resistant protein arrays and methods for making the same
AU2003262452B2 (en) * 1998-07-14 2007-02-08 Zyomyx, Inc. Arrays of proteins and methods of use thereof I
US6682942B1 (en) 1998-07-14 2004-01-27 Zyomyx, Inc. Microdevices for screening biomolecules
US6576478B1 (en) 1998-07-14 2003-06-10 Zyomyx, Inc. Microdevices for high-throughput screening of biomolecules
US6291190B1 (en) 1998-08-25 2001-09-18 The Board Of Trustees Of The Leland Stanford Junior University Molecular differences between species of the M. tuberculosis complex
US6929912B2 (en) 1998-08-31 2005-08-16 Genaissance Pharmaceuticals, Inc. Methods for evaluating the ability to metabolize pharmaceuticals
US6461812B2 (en) 1998-09-09 2002-10-08 Agilent Technologies, Inc. Method and multiple reservoir apparatus for fabrication of biomolecular arrays
US6309891B1 (en) * 1998-09-09 2001-10-30 Incyte Genomics, Inc. Capillary printing systems
US20020012913A1 (en) * 1998-09-15 2002-01-31 Kevin L. Gunderson Nucleic acid analysis using complete n-mer arrays
US6475440B1 (en) 1998-09-16 2002-11-05 Clontech Laboratories, Inc. Applicator for use in deposition of fluid samples onto a substrate surface
US7079241B2 (en) 2000-04-06 2006-07-18 Invitrogen Corp. Spatial positioning of spectrally labeled beads
US6703228B1 (en) * 1998-09-25 2004-03-09 Massachusetts Institute Of Technology Methods and products related to genotyping and DNA analysis
US6277628B1 (en) 1998-10-02 2001-08-21 Incyte Genomics, Inc. Linear microarrays
US7014815B1 (en) 1998-10-30 2006-03-21 Burstein Technologies, Inc. Trackable optical discs with concurrently readable nonoperational features
US6689323B2 (en) 1998-10-30 2004-02-10 Agilent Technologies Method and apparatus for liquid transfer
US6545264B1 (en) 1998-10-30 2003-04-08 Affymetrix, Inc. Systems and methods for high performance scanning
CN1331700A (zh) 1998-11-16 2002-01-16 基因纬生物技术公司 通过禽类中使用多核苷酸疫苗接种生成抗体的方法
US6309828B1 (en) 1998-11-18 2001-10-30 Agilent Technologies, Inc. Method and apparatus for fabricating replicate arrays of nucleic acid molecules
US6184347B1 (en) * 1998-11-19 2001-02-06 Agilent Technologies Inc. Minimization of blooming in high-density arrays by using reactive wash reagents
US6441152B1 (en) * 1998-12-08 2002-08-27 Boston Probes, Inc. Methods, kits and compositions for the identification of nucleic acids electrostatically bound to matrices
US6881570B1 (en) * 1998-12-15 2005-04-19 Fuji Photo Film Co., Ltd. Test piece and quantitative method and apparatus for an organism-oriented substance
US6351712B1 (en) * 1998-12-28 2002-02-26 Rosetta Inpharmatics, Inc. Statistical combining of cell expression profiles
US6429027B1 (en) 1998-12-28 2002-08-06 Illumina, Inc. Composite arrays utilizing microspheres
US7612020B2 (en) * 1998-12-28 2009-11-03 Illumina, Inc. Composite arrays utilizing microspheres with a hybridization chamber
US20030180789A1 (en) * 1998-12-30 2003-09-25 Dale Roderic M.K. Arrays with modified oligonucleotide and polynucleotide compositions
US6087112A (en) 1998-12-30 2000-07-11 Oligos Etc. Inc. Arrays with modified oligonucleotide and polynucleotide compositions
ATE277065T1 (de) 1999-01-05 2004-10-15 Bio Merieux Funktionalisierte verbindung, gegebenenfalls markierte polynukleotide und verfahren zur detektion einer ziel-nukleinsäure
AU772719B2 (en) * 1999-01-08 2004-05-06 Applera Corporation Fiber array for contacting chemical species and methods for using and making same
US20050026209A1 (en) * 1999-01-08 2005-02-03 Vann Charles S. Optical fiber bundle for detecting binding of chemical species
US7595189B2 (en) * 1999-01-08 2009-09-29 Applied Biosystems, Llc Integrated optics fiber array
US6720139B1 (en) 1999-01-27 2004-04-13 Elitra Pharmaceuticals, Inc. Genes identified as required for proliferation in Escherichia coli
US6251601B1 (en) * 1999-02-02 2001-06-26 Vysis, Inc. Simultaneous measurement of gene expression and genomic abnormalities using nucleic acid microarrays
US9534254B1 (en) 1999-02-02 2017-01-03 Abbott Molecular Inc. Patient stratification for cancer therapy based on genomic DNA microarray analysis
US6429302B1 (en) 1999-02-02 2002-08-06 Chiron Corporation Polynucleotides related to pancreatic disease
US6232129B1 (en) 1999-02-03 2001-05-15 Peter Wiktor Piezoelectric pipetting device
EP1026259B1 (en) * 1999-02-08 2002-11-27 Fuji Photo Film Co., Ltd. Process for preparing a dna chip
US6432719B1 (en) 1999-02-16 2002-08-13 Pe Corporation (Ny) Matrix storage and dispensing system
US7101510B2 (en) 1999-02-16 2006-09-05 Applera Corporation Matrix storage and dispensing system
US7365183B2 (en) 2001-01-03 2008-04-29 Ceres, Inc. Sequence-determined DNA fragments encoding SRF-type transcription factor proteins
EP1586645A3 (en) 1999-02-25 2006-02-22 Ceres Incorporated Sequence-determined DNA fragments and corresponding polypeptides encoded thereby
US8710201B2 (en) 1999-12-08 2014-04-29 Ceres, Inc. Nucleic acid sequences encoding strictosidine synthase proteins
US8710204B2 (en) 1999-02-25 2014-04-29 Ceres, Inc. Nucleic acid sequences encoding secE/sec61-gamma subunits of protein translocation complexes
US7659386B2 (en) 2000-08-03 2010-02-09 Ceres, Inc. Nucleic acid sequences encoding transcription factor proteins
US8299231B2 (en) 1999-03-09 2012-10-30 Ceres, Inc. Nucleic acid sequences encoding AN1-like zinc finger proteins
US6627157B1 (en) 1999-03-04 2003-09-30 Ut-Battelle, Llc Dual manifold system and method for fluid transfer
US9000140B2 (en) 1999-03-05 2015-04-07 Ceres, Inc. Sequence-determined DNA fragments encoding AN1-like zinc finger proteins
FR2790766B1 (fr) * 1999-03-08 2002-12-20 Commissariat Energie Atomique Procede de realisation d'une matrice de sequences de molecules chimiques ou biologiques pour dispositif d'analyse chimique ou biologique
US6296702B1 (en) 1999-03-15 2001-10-02 Pe Corporation (Ny) Apparatus and method for spotting a substrate
CN1348396A (zh) * 1999-03-19 2002-05-08 金克克国际有限公司 用于高效筛选的多通孔测试板
EP1235855A2 (en) * 1999-03-22 2002-09-04 Novozymes Biotech, Inc. Methods for monitoring multiple gene expression
AU4025300A (en) * 1999-03-24 2000-10-09 Packard Bioscience Company Continuous porous matrix arrays
US6347259B1 (en) 1999-04-01 2002-02-12 Virtek Vision International Inc. High precision positioning device and method of operating same
US6235479B1 (en) 1999-04-13 2001-05-22 Bio Merieux, Inc. Methods and devices for performing analysis of a nucleic acid sample
CA2371976A1 (en) * 1999-04-15 2000-10-26 Peter Cox A novel family of beta sub-unit proteins from a voltage-gated sodium channel, nucleic acids encoding them and therapeutic or diagnostic uses thereof
EP1169649A2 (en) * 1999-04-15 2002-01-09 The Board Of Trustees Of The Leland Stanford Junior University Microarrays of polypeptides
US6245297B1 (en) 1999-04-16 2001-06-12 Pe Corporation (Ny) Apparatus and method for transferring small volumes of substances
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US20030207295A1 (en) * 1999-04-20 2003-11-06 Kevin Gunderson Detection of nucleic acid reactions on bead arrays
ATE504937T1 (de) * 1999-04-27 2011-04-15 Bio Rad Laboratories Probenhalter für ein gasphaseionenspektrometer
US20040197817A1 (en) * 1999-04-30 2004-10-07 Caren Michael P. Polynucleotide array fabrication
JP2001021558A (ja) * 1999-04-30 2001-01-26 Agilent Technol Inc ポリヌクレオチドアレイの製作法
US7276336B1 (en) 1999-07-22 2007-10-02 Agilent Technologies, Inc. Methods of fabricating an addressable array of biopolymer probes
US6395559B1 (en) * 1999-05-04 2002-05-28 Orchid Biosciences, Inc. Multiple fluid sample processor with single well addressability
US7932213B2 (en) * 1999-05-11 2011-04-26 President And Fellows Of Harvard College Small molecule printing
US20020182749A1 (en) * 1999-05-11 2002-12-05 Aclara Biosciences, Inc. Sample evaporative control
US6824987B1 (en) 1999-05-11 2004-11-30 President And Fellows Of Harvard College Small molecule printing
US6852493B2 (en) * 1999-05-14 2005-02-08 Iris Biotechnologies, Inc. Magnetic field enhanced hybridization of target molecules to immobilized probes
JP3957118B2 (ja) * 1999-05-18 2007-08-15 富士フイルム株式会社 試験片およびこの試験片からの画像情報読取装置
JP4598960B2 (ja) * 1999-05-19 2010-12-15 エッペンドルフ アレイ テクノロジーズ エスアー （エーアーテー） 生物学的サンプルから得られた標的化合物のチップ上での同定及び／又は定量方法
US20030096321A1 (en) * 1999-05-19 2003-05-22 Jose Remacle Method for the identification and/or the quantification of a target compound obtained from a biological sample upon chips
US6365410B1 (en) * 1999-05-19 2002-04-02 Genencor International, Inc. Directed evolution of microorganisms
US20030186311A1 (en) * 1999-05-21 2003-10-02 Bioforce Nanosciences, Inc. Parallel analysis of molecular interactions
US20020042081A1 (en) * 2000-10-10 2002-04-11 Eric Henderson Evaluating binding affinities by force stratification and force panning
CA2374515A1 (en) 1999-05-21 2000-11-30 Christian E. Gruber Compositions and methods for labeling of nucleic acid molecules
US20030073250A1 (en) * 1999-05-21 2003-04-17 Eric Henderson Method and apparatus for solid state molecular analysis
US6573369B2 (en) * 1999-05-21 2003-06-03 Bioforce Nanosciences, Inc. Method and apparatus for solid state molecular analysis
US6225109B1 (en) * 1999-05-27 2001-05-01 Orchid Biosciences, Inc. Genetic analysis device
WO2000072969A1 (en) 1999-05-27 2000-12-07 The Perkin-Elmer Corporation Apparatus and method for the precise location of reaction plates
AU5870200A (en) * 1999-06-03 2000-12-28 Jonathan Hibbs Non-cognate hybridization system (nchs)
US6716579B1 (en) 1999-06-11 2004-04-06 Narayan Baidya Gene specific arrays, preparation and use
WO2000079006A1 (en) * 1999-06-17 2000-12-28 Fred Hutchinson Cancer Research Center Oligonucleotide arrays for high resolution hla typing
US7485715B2 (en) 1999-06-18 2009-02-03 Ceres, Inc. Sequence-determined DNA encoding AP2 domain polypeptides
US6296673B1 (en) * 1999-06-18 2001-10-02 The Regents Of The University Of California Methods and apparatus for performing array microcrystallizations
US7420049B2 (en) 1999-06-18 2008-09-02 Ceres, Inc. Sequence-determined DNA fragments encoding AP2 domain proteins
US6630006B2 (en) * 1999-06-18 2003-10-07 The Regents Of The University Of California Method for screening microcrystallizations for crystal formation
US7399850B2 (en) 1999-06-18 2008-07-15 Ceres, Inc. Sequence-determined DNA fragments encoding AP2 domain proteins
US6656682B1 (en) 1999-06-21 2003-12-02 Nisshinbo Industries, Inc. Nucleic acid-immobilized substrate
US6399394B1 (en) 1999-06-30 2002-06-04 Agilent Technologies, Inc. Testing multiple fluid samples with multiple biopolymer arrays
EP1208126B1 (en) 1999-07-02 2006-04-12 Symyx Technologies, Inc. Polymer brushes for immobilizing molecules to a surface or substrate, where the polymers have water-soluble or water-dispersible segments and probes bonded thereto
GB9916406D0 (en) * 1999-07-13 1999-09-15 Biorobotics Ltd Liquid transfer pin
US7371516B1 (en) * 1999-07-16 2008-05-13 Rosetta Inpharmatics Llc Methods for determining the specificity and sensitivity of oligonucleo tides for hybridization
US6306599B1 (en) * 1999-07-16 2001-10-23 Agilent Technologies Inc. Biopolymer arrays and their fabrication
US6346423B1 (en) 1999-07-16 2002-02-12 Agilent Technologies, Inc. Methods and compositions for producing biopolymeric arrays
US7209836B1 (en) * 1999-07-16 2007-04-24 Perkinelmer Las, Inc. Method and system for automatically creating crosstalk-corrected data of a microarray
GB2348002B (en) * 1999-07-20 2001-02-07 Genpak Ltd Microarrayer
DE19933838A1 (de) * 1999-07-20 2001-02-01 Max Planck Gesellschaft Nadel und Verfahren zum Transfer von Liquiden sowie Verfahren zum Herstellen der Nadel
US7479555B2 (en) 1999-07-21 2009-01-20 Ceres, Inc. Polynucleotides having a nucleotide sequence that encodes a polypeptide having MOV34 family activity
US20030170908A1 (en) * 2000-07-28 2003-09-11 Bright Frank V. Method for making microsensor arrays for detecting analytes
US20090011945A1 (en) * 1999-07-28 2009-01-08 Bright Frank V Method For Making Microsensor Arrays For Detecting Analytes
US6470277B1 (en) * 1999-07-30 2002-10-22 Agy Therapeutics, Inc. Techniques for facilitating identification of candidate genes
KR100320752B1 (ko) * 1999-08-06 2002-01-17 박한오 자동 시료 미세배열 장치
EP1203016A2 (en) * 1999-08-09 2002-05-08 Incyte Genomics, Inc. Proteases and protease inhibitors
EP1075869B1 (en) * 1999-08-09 2006-06-14 Thk Co. Ltd. Micro array manufacturing apparatus
US6498032B1 (en) * 1999-08-11 2002-12-24 Corning Incorporated Use of ceramic labels for identifying biomolecule immobilizing subtrates
CA2391758C (en) * 1999-08-13 2010-02-16 Cartesian Technologies, Inc. Apparatus for liquid sample handling
EP1208238B1 (en) * 1999-08-27 2008-11-12 Matrix Technologies Corporation Methods of immobilizing ligands on solid supports
WO2001016376A1 (en) * 1999-09-02 2001-03-08 Corning Incorporated Porous substrates for dna arrays
US6528319B1 (en) 1999-09-02 2003-03-04 Amersham Biosciences Corp Method for anchoring oligonucleotides to a substrate
US6994972B2 (en) * 1999-09-02 2006-02-07 Corning Incorporated Porous substrates for DNA arrays
US6750023B2 (en) * 1999-09-02 2004-06-15 Corning Incorporated Porous inorganic substrate for high-density arrays
AU7353500A (en) * 1999-09-10 2001-04-10 Incyte Genomics, Inc. Apoptosis proteins
FR2798673B1 (fr) * 1999-09-16 2004-05-28 Exonhit Therapeutics Sa Methodes et compositions pour la detection d'evenements pathologiques
US20020006664A1 (en) * 1999-09-17 2002-01-17 Sabatini David M. Arrayed transfection method and uses related thereto
US7122303B2 (en) * 1999-09-17 2006-10-17 Agilent Technologies, Inc. Arrays comprising background features that provide for a measure of a non-specific binding and methods for using the same
WO2001020015A1 (en) * 1999-09-17 2001-03-22 Whitehead Institute For Biomedical Research Reverse transfection method
US7078167B2 (en) * 1999-09-17 2006-07-18 Agilent Technologies, Inc. Arrays having background features and methods for using the same
EP2343128A1 (en) * 1999-09-17 2011-07-13 BioArray Solutions Ltd. Substrate and chip for conducting bioassays
US6623936B1 (en) 1999-09-24 2003-09-23 Imgenex Compositions and methods for improved detection and classification of neoplasms
DE19946525A1 (de) * 1999-09-28 2001-05-03 Fraunhofer Ges Forschung Vorrichtung zur Aufnahme und Abgabe kleinster Flüssigkeitsmengen
US6844151B1 (en) 1999-09-29 2005-01-18 Oligos Etc. Inc. Methods for production of arrays with modified oligonucleotide and polynucleotide compositions
US6558623B1 (en) * 2000-07-06 2003-05-06 Robodesign International, Inc. Microarray dispensing with real-time verification and inspection
US20030190644A1 (en) * 1999-10-13 2003-10-09 Andreas Braun Methods for generating databases and databases for identifying polymorphic genetic markers
US6607885B1 (en) 1999-10-15 2003-08-19 E. I. Du Pont De Nemours And Company Method for high-density microarray medicated gene expression profiling
US6709816B1 (en) * 1999-10-18 2004-03-23 Affymetrix, Inc. Identification of alleles
US6171797B1 (en) 1999-10-20 2001-01-09 Agilent Technologies Inc. Methods of making polymeric arrays
US20030036070A1 (en) * 1999-10-21 2003-02-20 Shukti Chakravarti Gene expression profiling of inflammatory bowel disease
JP2001186880A (ja) * 1999-10-22 2001-07-10 Ngk Insulators Ltd Ｄｎａチップの製造方法
JP2001186881A (ja) * 1999-10-22 2001-07-10 Ngk Insulators Ltd Ｄｎａチップの製造方法
US6656432B1 (en) * 1999-10-22 2003-12-02 Ngk Insulators, Ltd. Micropipette and dividedly injectable apparatus
US6958225B2 (en) * 1999-10-27 2005-10-25 Affymetrix, Inc. Complexity management of genomic DNA
US6689319B1 (en) 1999-10-29 2004-02-10 Agilent Technologies, Ind. Apparatus for deposition and inspection of chemical and biological fluids
EP1230397A2 (en) * 1999-11-02 2002-08-14 Celine Hu Molecular microarrays and methods for production and use thereof
US6362004B1 (en) * 1999-11-09 2002-03-26 Packard Biochip Technologies, Llc Apparatus and method for using fiducial marks on a microarray substrate
WO2001034810A2 (en) 1999-11-09 2001-05-17 Elitra Pharmaceuticals, Inc. Genes essential for microbial proliferation
US7420046B2 (en) 1999-11-10 2008-09-02 Ceres, Inc. Sequence-determined DNA fragments encoding RNA polymerase proteins
US7041445B2 (en) * 1999-11-15 2006-05-09 Clontech Laboratories, Inc. Long oligonucleotide arrays
US7109024B2 (en) * 1999-11-15 2006-09-19 Dr. Chip Biotechnology Inc. Biomolecule-bound substrates
GB2356063B (en) * 1999-11-22 2001-10-24 Genpak Ltd Adhesive label with grid for microscope slide
US6446642B1 (en) * 1999-11-22 2002-09-10 Agilent Technologies, Inc. Method and apparatus to clean an inkjet reagent deposition device
US6423535B1 (en) 1999-11-24 2002-07-23 Incyte Genomics, Inc. Normalization control for hybridization reactions
EP1235939A2 (en) * 1999-11-24 2002-09-04 Incyte Genomics, Inc. Normalization controls and duplex probes for quantitative hybridization reactions
JP2001149060A (ja) 1999-11-29 2001-06-05 Nisshinbo Ind Inc 核酸固定化基板
CN1840607B (zh) * 1999-12-01 2010-06-09 普林斯顿大学理事会 作为有机发光器件的磷光掺杂剂的l2mx形式的络合物
EP1238095A4 (en) * 1999-12-16 2004-07-28 Univ Louisville Res Found COMPOSITIONS AND METHODS FOR CASPASE-INDUCED APOPTOSIS
US6902891B2 (en) 1999-12-17 2005-06-07 Bio Merieux Process for labeling a nucleic acid
US6489114B2 (en) 1999-12-17 2002-12-03 Bio Merieux Process for labeling a ribonucleic acid, and labeled RNA fragments which are obtained thereby
KR20030003221A (ko) * 1999-12-23 2003-01-09 엘리트라 파마슈티컬즈, 인코포레이티드 대장균 증식에 필요한 유전자
EP1255860A2 (en) 1999-12-29 2002-11-13 Mergen Ltd. Methods for amplifying and detecting multiple polynucleotides on a solid phase support
US6620625B2 (en) * 2000-01-06 2003-09-16 Caliper Technologies Corp. Ultra high throughput sampling and analysis systems and methods
US20050095696A9 (en) * 2000-01-07 2005-05-05 Lemmo Anthony V. Apparatus and method for high-throughput preparation and characterization of compositions
US20070020662A1 (en) * 2000-01-07 2007-01-25 Transform Pharmaceuticals, Inc. Computerized control of high-throughput experimental processing and digital analysis of comparative samples for a compound of interest
US20070021929A1 (en) * 2000-01-07 2007-01-25 Transform Pharmaceuticals, Inc. Computing methods for control of high-throughput experimental processing, digital analysis, and re-arraying comparative samples in computer-designed arrays
KR20020071931A (ko) * 2000-01-07 2002-09-13 트렌스폼 파마수티컬스 인코퍼레이티드 다양한 고체-형태들의 고도의 자료 처리 편성, 확인 및분석
US20050089923A9 (en) * 2000-01-07 2005-04-28 Levinson Douglas A. Method and system for planning, performing, and assessing high-throughput screening of multicomponent chemical compositions and solid forms of compounds
US6977723B2 (en) * 2000-01-07 2005-12-20 Transform Pharmaceuticals, Inc. Apparatus and method for high-throughput preparation and spectroscopic classification and characterization of compositions
US7108970B2 (en) * 2000-01-07 2006-09-19 Transform Pharmaceuticals, Inc. Rapid identification of conditions, compounds, or compositions that inhibit, prevent, induce, modify, or reverse transitions of physical state
US20050118637A9 (en) * 2000-01-07 2005-06-02 Levinson Douglas A. Method and system for planning, performing, and assessing high-throughput screening of multicomponent chemical compositions and solid forms of compounds
DE60033851T2 (de) 2000-01-11 2007-11-08 Nanogen Recognomics Gmbh Biomoleküle mit multiplen anbindungsabschnitten zur bindung an eine substratoberfläche
WO2001051667A2 (en) 2000-01-14 2001-07-19 Integriderm, L.L.C. Informative nucleic acid arrays and methods for making same
US7429466B2 (en) * 2000-01-24 2008-09-30 Hypromatrix, Inc Methods and arrays for detecting biological molecules
US8143195B2 (en) * 2000-01-24 2012-03-27 Yingjian Wang Arrays for bringing two or more reagents in contact with one or more biological targets and methods for making and using the arrays
US20030097222A1 (en) * 2000-01-25 2003-05-22 Craford David M. Method, system, and computer software for providing a genomic web portal
US6587579B1 (en) * 2000-01-26 2003-07-01 Agilent Technologies Inc. Feature quality in array fabrication
US7355026B2 (en) 2000-01-27 2008-04-08 Ceres, Inc. Sequence-determined DNA fragments encoding SRF-type transcription factor proteins
US6618679B2 (en) 2000-01-28 2003-09-09 Althea Technologies, Inc. Methods for analysis of gene expression
US6399396B1 (en) * 2000-01-28 2002-06-04 Agilent Technologies, Inc. Compressed loading apparatus and method for liquid transfer
US8076063B2 (en) 2000-02-07 2011-12-13 Illumina, Inc. Multiplexed methylation detection methods
US7955794B2 (en) 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US20020006617A1 (en) * 2000-02-07 2002-01-17 Jian-Bing Fan Nucleic acid detection methods using universal priming
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
CA2399908A1 (en) * 2000-02-10 2001-08-16 Todd Dickinson Array of individual arrays as substrate for bead-based simultaneous processing of samples and manufacturing method therefor
US6770441B2 (en) 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
US6783985B1 (en) 2000-02-18 2004-08-31 Elitra Pharmaceuticals Inc. Gene disruption methodologies for drug target discovery
US20020151040A1 (en) 2000-02-18 2002-10-17 Matthew O' Keefe Apparatus and methods for parallel processing of microvolume liquid reactions
AU2001238606A1 (en) 2000-02-18 2001-08-27 Board Of Trustees Of The Leland Stanford Junior University Apparatus and methods for parallel processing of micro-volume liquid reactions
US7160511B2 (en) 2000-02-18 2007-01-09 Olympus Corporation Liquid pipetting apparatus and micro array manufacturing apparatus
AU6291301A (en) * 2000-02-22 2001-09-03 Genospectra, Inc. Microarray fabrication techniques and apparatus
US20040014102A1 (en) * 2000-02-22 2004-01-22 Shiping Chen High density parallel printing of microarrays
CN1404415A (zh) * 2000-02-22 2003-03-19 基因谱公司 微阵列制造技术及设备
EP1299713A1 (de) * 2000-02-28 2003-04-09 Variom Biotechnology AG Bauteil mit einer mehrzahl von fiberelementen und an den fiberelementen immobilisierten probenmolekülen
EP1305605A2 (de) * 2000-02-28 2003-05-02 Variom Biotechnology AG Bauteil zur interaktionsanalyse mit kooperationseffekte ausbildenden probenmolekülspezies
US6897015B2 (en) * 2000-03-07 2005-05-24 Bioforce Nanosciences, Inc. Device and method of use for detection and characterization of pathogens and biological materials
ITCA20000004A1 (it) * 2000-03-07 2001-09-07 Mario Raimondo Caria Metodo e sistema per la rivelazione simultanea e multipla con quantificazione della ibridizzazione di composti molecolari quali acidi nuclei
WO2001066733A1 (fr) * 2000-03-07 2001-09-13 Chiba-Prefecture Sequences d'acides nucleiques presentant une expression accrue dans le neuroblastome benin par rapport au neuroblastome humain acritique
US6537433B1 (en) 2000-03-10 2003-03-25 Applera Corporation Methods and apparatus for the location and concentration of polar analytes using an alternating electric field
US6447723B1 (en) 2000-03-13 2002-09-10 Packard Instrument Company, Inc. Microarray spotting instruments incorporating sensors and methods of using sensors for improving performance of microarray spotting instruments
US20060252920A1 (en) 2001-08-10 2006-11-09 Nickolai Alexandrov Sequence-determined DNA fragments encoding cyclopropyl isomerase proteins
US6878554B1 (en) 2000-03-20 2005-04-12 Perkinelmer Las, Inc. Method and apparatus for automatic pin detection in microarray spotting instruments
US6756232B1 (en) * 2000-03-20 2004-06-29 Perkinelmer Las, Inc. Method and apparatus for producing compact microarrays
US6413722B1 (en) 2000-03-22 2002-07-02 Incyte Genomics, Inc. Polymer coated surfaces for microarray applications
US6376191B1 (en) 2000-03-22 2002-04-23 Mergen, Ltd. Microarray-based analysis of polynucleotide sequence variations
JP4152054B2 (ja) * 2000-03-23 2008-09-17 富士フイルム株式会社 画像読み取り装置
US20080085515A1 (en) * 2000-03-24 2008-04-10 Eppendorf Array Technologies Sa (Eat) Identification of multiple biological (micro) organisms by detection of their nucleotide sequences on arrays
US7202026B2 (en) * 2000-03-24 2007-04-10 Eppendorf Array Technologies Sa (Eat) Identification of a large number of biological (micro)organisms groups at different levels by their detection on a same array
KR100340126B1 (ko) * 2000-03-24 2002-06-10 박한오 자동 생물학적 시료 미세배열 장치
US7205104B2 (en) * 2000-03-24 2007-04-17 Eppendorf Array Technologies Sa (Eat) Identification of biological (micro) organisms by detection of their homologous nucleotide sequences on arrays
US7875442B2 (en) * 2000-03-24 2011-01-25 Eppendorf Array Technologies Identification and quantification of a plurality of biological (micro)organisms or their components
US7829313B2 (en) * 2000-03-24 2010-11-09 Eppendorf Array Technologies Identification and quantification of a plurality of biological (micro)organisms or their components
US6800455B2 (en) * 2000-03-31 2004-10-05 Scios Inc. Secreted factors
US20050003364A1 (en) * 2000-03-31 2005-01-06 Stanton Lawrence W. Secreted factors
WO2001075162A2 (en) * 2000-03-31 2001-10-11 University Of Louisville Research Foundation, Inc. Microarrays to screen regulatory genes
EP1276702A2 (en) * 2000-03-31 2003-01-22 Genentech, Inc. Compositions and methods for detecting and quantifying gene expression
JP4425420B2 (ja) * 2000-04-03 2010-03-03 独立行政法人理化学研究所 マイクロアレイ作製装置
DE10017105A1 (de) * 2000-04-06 2001-10-11 Basf Ag Verfahren und Vorrichtung zur Herstellung von Biopolymer-Feldern
GB0008563D0 (en) * 2000-04-07 2000-05-24 Cambridge Discovery Chemistry Investigating different physical and/or chemical forms of materials
US7691991B2 (en) 2000-04-17 2010-04-06 Ceres, Inc. Sequence-determined DNA fragments encoding cytochrome P450 proteins
DE10020704B4 (de) * 2000-04-27 2006-09-28 Bioref Gmbh Biochip zur Archivierung und labormedizinischen Analyse von biologischem Probenmaterial, Verfahren zu dessen Herstellung sowie dessen Verwendung in diagnostischen Verfahren
CA2408094A1 (en) * 2000-05-04 2001-11-08 The Center For Blood Research, Inc. Colloid compositions for solid phase biomolecular analytical, preparative and identification systems
CA2408291C (en) 2000-05-04 2014-07-15 Yale University High density protein arrays for screening of protein activity
US6709840B1 (en) 2000-05-11 2004-03-23 The Board Of Trustees Of The Leland Stanford Junior University Anergy associated genes
US6902882B2 (en) 2000-05-23 2005-06-07 Kerong Gu Methods of monitoring production of gene products and uses thereof
EP1313880A2 (en) * 2000-05-30 2003-05-28 PE Corporation (NY) Methods for detecting target nucleic acids using coupled ligation and amplification
WO2005000087A2 (en) * 2003-06-03 2005-01-06 Chiron Corporation Gene products differentially expressed in cancerous colon cells and their methods of use ii
US7700359B2 (en) * 2000-06-02 2010-04-20 Novartis Vaccines And Diagnostics, Inc. Gene products differentially expressed in cancerous cells
WO2003057926A1 (en) 2002-01-08 2003-07-17 Chiron Corporation Gene products differentially expressed in cancerous breast cells and their methods of use
US7521245B1 (en) 2000-06-05 2009-04-21 Perkinelmer Las, Inc. Method for washing and drying pins in microarray spotting instruments
US6455007B1 (en) * 2000-06-13 2002-09-24 Symyx Technologies, Inc. Apparatus and method for testing compositions in contact with a porous medium
EP1373561B1 (en) 2000-06-13 2009-02-18 The Trustees of Boston University Use of mass-matched nucleotides in the analysis of oligonucleotide mixtures and in highly multiplexed nucleic acid sequencing
EP1164201A1 (en) * 2000-06-14 2001-12-19 Facultés Universitaires Notre-Dame de la Paix Reverse detection for identification and/or quantification of nucleotide target sequences on biochips
ES2398391T3 (es) 2000-06-15 2013-03-15 Novartis Vaccines And Diagnostics, Inc. Polinucleótidos relacionados con cáncer de colon
ATE432350T1 (de) 2000-06-16 2009-06-15 Incyte Corp G-protein gekoppelte rezeptoren
AU2001269906A1 (en) * 2000-06-19 2002-01-02 Zyomyx, Inc. Methods for immobilizing polypeptides
US7062418B2 (en) 2000-06-27 2006-06-13 Fluidigm Corporation Computer aided design method and system for developing a microfluidic system
US7584761B1 (en) 2000-06-30 2009-09-08 Lam Research Corporation Wafer edge surface treatment with liquid meniscus
US7234477B2 (en) * 2000-06-30 2007-06-26 Lam Research Corporation Method and apparatus for drying semiconductor wafer surfaces using a plurality of inlets and outlets held in close proximity to the wafer surfaces
US7000622B2 (en) * 2002-09-30 2006-02-21 Lam Research Corporation Methods and systems for processing a bevel edge of a substrate using a dynamic liquid meniscus
US20030219816A1 (en) * 2001-07-02 2003-11-27 Keith Solomon Composite microarray slides
US7025933B2 (en) * 2000-07-06 2006-04-11 Robodesign International, Inc. Microarray dispensing with real-time verification and inspection
US6913879B1 (en) 2000-07-10 2005-07-05 Telechem International Inc. Microarray method of genotyping multiple samples at multiple LOCI
US6599693B1 (en) * 2000-07-31 2003-07-29 Agilent Technologies Inc. Array fabrication
US6890760B1 (en) * 2000-07-31 2005-05-10 Agilent Technologies, Inc. Array fabrication
US7205400B2 (en) * 2000-07-31 2007-04-17 Agilent Technologies, Inc. Array fabrication
US6613893B1 (en) 2000-07-31 2003-09-02 Agilent Technologies Inc. Array fabrication
US20020102617A1 (en) * 2000-08-03 2002-08-01 Macbeath Gavin Protein microarrays
WO2002012893A2 (en) * 2000-08-03 2002-02-14 Massachusetts Institute Of Technology Microarrays of functional biomolecules, and uses therefor
US6984522B2 (en) 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
US9085771B2 (en) 2001-01-03 2015-07-21 Ceres, Inc. Sequence-determined DNA fragments with regulatory functions
US7390893B2 (en) 2000-08-07 2008-06-24 Ceres, Inc. Sequence-determined DNA fragments encoding peptide transport proteins
US10106586B2 (en) 2000-08-07 2018-10-23 Ceres, Inc. Sequence-determined DNA fragments encoding peptide transport proteins
JP3398366B2 (ja) * 2000-08-09 2003-04-21 富士写真フイルム株式会社 Ｄｎａ分析用マイクロアレイの製造方法
US7129229B2 (en) * 2000-08-11 2006-10-31 Nanogen Recognomics Gmbh Hydrazide building blocks and hydrazide modified biomolecules
ATE402760T1 (de) * 2000-08-15 2008-08-15 Bioforce Nanosciences Inc Vorrichtung zur bildung von nanomolekularen netzwerken
US7198924B2 (en) 2000-12-11 2007-04-03 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
US6789040B2 (en) 2000-08-22 2004-09-07 Affymetrix, Inc. System, method, and computer software product for specifying a scanning area of a substrate
US6965704B2 (en) * 2000-08-22 2005-11-15 Affymetrix, Inc. System, method, and computer software product for grid alignment of multiple scanned images
US20040161789A1 (en) * 2000-08-30 2004-08-19 Tanner Cameron W. Porous inorganic substrate for high-density arrays
US9024004B2 (en) 2000-08-31 2015-05-05 Ceres, Inc. Sequence-determined DNA fragments encoding acetohydroxyacid synthase proteins
US7608441B2 (en) 2000-08-31 2009-10-27 Ceres, Inc. Sequence-determined DNA fragments encoding sterol desaturase proteins
US20030190612A1 (en) * 2000-08-31 2003-10-09 Nobuko Yamamoto Detecting method and detection substrate for use therein
US20040185464A1 (en) * 2000-09-15 2004-09-23 Kris Richard M. High throughput assay system
AU2001292959A1 (en) * 2000-09-22 2002-04-02 Clontech Laboratories, Inc. Highly sensitive proteomic analysis methods and kits and systems for practicing the same
US7900505B2 (en) 2000-09-25 2011-03-08 Labcyte Inc. Acoustic assessment of fluids in a plurality of reservoirs
US20020061258A1 (en) * 2000-09-25 2002-05-23 Mutz Mitchell W. Focused acoustic energy in the preparation and screening of combinatorial libraries
JP4990476B2 (ja) * 2000-09-25 2012-08-01 ピコリター インコーポレイテッド コンビナトリアルライブラリの調製およびスクリーニングにおける集束された音響エネルギー
US20020037359A1 (en) 2000-09-25 2002-03-28 Mutz Mitchell W. Focused acoustic energy in the preparation of peptide arrays
US6642061B2 (en) 2000-09-25 2003-11-04 Picoliter Inc. Use of immiscible fluids in droplet ejection through application of focused acoustic energy
JP4955901B2 (ja) * 2000-09-25 2012-06-20 ピコリター インコーポレイテッド 非混和性流体の液滴を生成するための集束音響エネルギー法およびデバイス
JP4624644B2 (ja) * 2000-09-25 2011-02-02 ピコリター インコーポレイテッド 複数のリザブワーからの流体の音響出射
US6548308B2 (en) 2000-09-25 2003-04-15 Picoliter Inc. Focused acoustic energy method and device for generating droplets of immiscible fluids
US20030082604A1 (en) * 2000-09-27 2003-05-01 Swanson Melvin J. High density arrays
US20060141507A1 (en) * 2000-09-27 2006-06-29 Kronick Mel N Manufacture and use of non-standard size microarray slides
US6658324B2 (en) 2000-09-29 2003-12-02 Gpc Biotech Ag Pick and place robot system
EP2311855A3 (en) 2000-10-06 2011-05-11 Novozymes Inc. Bacillus licheniformis YvnA negative strain
US8168773B2 (en) 2000-10-06 2012-05-01 Novozymes, Inc. Methods for monitoring multiple gene expression
WO2002030486A2 (en) 2000-10-13 2002-04-18 Fluidigm Corporation Microfluidic device based sample injection system for analytical devices
US6849409B2 (en) * 2000-10-16 2005-02-01 Axxima Pharmaceuticals Ag Cellular kinases involved in Cytomegalovirus infection and their inhibition
US7604971B2 (en) 2000-10-19 2009-10-20 Ceres, Inc. Sequence-determined DNA fragments encoding UBIE/COQ5 methyltransferase family proteins
WO2002034944A1 (en) * 2000-10-23 2002-05-02 Dia Chip Limited High precision and intellectual biochip arrayer having function of respotting
US20020061538A1 (en) * 2000-10-26 2002-05-23 Rajan Kumar Fluidic arrays
US20020051995A1 (en) * 2000-10-30 2002-05-02 Rajan Kumar Stacked arrays
JP4015946B2 (ja) 2000-10-30 2007-11-28 シークエノム・インコーポレーテツド 基板上にサブマイクロリットルの体積を供給する方法及び装置
US7608704B2 (en) * 2000-11-08 2009-10-27 Incyte Corporation Secreted proteins
US20020150887A1 (en) * 2000-11-09 2002-10-17 National Institute Of Advanced Industrial Science And Technology Methods and nucleic acid probes for molecular genetic analysis of polluted environments and environmental samples
US7033761B2 (en) 2000-11-14 2006-04-25 Shafer David A Expression miniarrays and uses thereof
US20020177138A1 (en) * 2000-11-15 2002-11-28 The United States Of America , Represented By The Secretary, Department Of Health And Human Services Methods for the indentification of textual and physical structured query fragments for the analysis of textual and biopolymer information
WO2002044695A1 (en) * 2000-11-16 2002-06-06 Burstein Technologies, Inc. Methods and apparatus for detecting and quantifying lymphocytes with optical biodiscs
US20050202470A1 (en) * 2000-11-16 2005-09-15 Caliper Life Sciences, Inc. Binding assays using molecular melt curves
US20030092009A1 (en) * 2000-11-16 2003-05-15 Kaia Palm Profiling tumor specific markers for the diagnosis and treatment of neoplastic disease
US7026131B2 (en) * 2000-11-17 2006-04-11 Nagaoka & Co., Ltd. Methods and apparatus for blood typing with optical bio-discs
US7087203B2 (en) * 2000-11-17 2006-08-08 Nagaoka & Co., Ltd. Methods and apparatus for blood typing with optical bio-disc
US6740530B1 (en) * 2000-11-22 2004-05-25 Xerox Corporation Testing method and configurations for multi-ejector system
JP2002153272A (ja) * 2000-11-24 2002-05-28 Inst Of Physical & Chemical Res 生体分子マイクロアレイ
JP4179876B2 (ja) 2000-11-27 2008-11-12 インテリジェント メディカル ディバイシーズ エル．エル． シー． 臨床的にインテリジェントな診断装置および方法
US6905816B2 (en) 2000-11-27 2005-06-14 Intelligent Medical Devices, Inc. Clinically intelligent diagnostic devices and methods
EP2336368A1 (en) 2000-12-07 2011-06-22 Novartis Vaccines and Diagnostics, Inc. Endogenous retroviruses up-regulated in prostate cancer
US20020069649A1 (en) * 2000-12-08 2002-06-13 Ardais Corporation Container for cryopreserved material
US20040262318A1 (en) * 2000-12-08 2004-12-30 Ardais Corporation Container, method and system for cryptopreserved material
AU2261802A (en) * 2000-12-12 2002-06-24 Masumi Abe Method of analyzing gene expression
WO2002057416A2 (en) * 2000-12-12 2002-07-25 Autogenomics, Inc. Improved biochip
US6448387B1 (en) * 2000-12-18 2002-09-10 Monsanto Technology, Llc Polymeric arrays adapted for high expressing polynucleotides
US7700274B2 (en) 2000-12-22 2010-04-20 Sagres Discovery, Inc. Compositions and methods in cancer associated with altered expression of KCNJ9
US7892730B2 (en) 2000-12-22 2011-02-22 Sagres Discovery, Inc. Compositions and methods for cancer
US7645441B2 (en) 2000-12-22 2010-01-12 Sagres Discovery Inc. Compositions and methods in cancer associated with altered expression of PRLR
US20030232334A1 (en) 2000-12-22 2003-12-18 Morris David W. Novel compositions and methods for cancer
AU2002245182A1 (en) * 2000-12-22 2002-07-08 Mergen Ltd. Methods for identifying g-protein coupled receptors associated with diseases
US7820447B2 (en) 2000-12-22 2010-10-26 Sagres Discovery Inc. Compositions and methods for cancer
US20020094304A1 (en) * 2000-12-22 2002-07-18 Tom Yang High speed liquid deposition apparatus for microarray fabrication
US20030180953A1 (en) * 2000-12-29 2003-09-25 Elitra Pharmaceuticals, Inc. Gene disruption methodologies for drug target discovery
US7385046B2 (en) 2001-01-03 2008-06-10 Ceres, Inc. Sequence-determined DNA fragments encoding ethylene responsive element binding proteins
US7368555B2 (en) 2001-01-03 2008-05-06 Ceres, Inc. Sequence-determined DNA fragments encoding EF-hand calcium-binding proteins
JP3605039B2 (ja) * 2001-01-09 2004-12-22 株式会社日立製作所 核酸マイクロアレイ、その製造方法及びそれを用いた核酸検出方法
AU2002246978A1 (en) * 2001-01-10 2002-07-24 Symyx Technologies, Inc. Polymer brushes for immobilizing molecules to a surface
FR2819524B1 (fr) * 2001-01-18 2003-07-04 Antonios Vekris Hybridation differentielle par competition
CA2435260A1 (en) * 2001-01-19 2002-07-25 Incyte Genomics, Inc. Receptors and membrane-associated proteins
KR20030071854A (ko) * 2001-02-06 2003-09-06 다카라 바이오 가부시키가이샤 증폭 핵산 및 그의 고정화물
US7087389B2 (en) * 2001-02-09 2006-08-08 Council Of Scientific & Industrial Research Highly cost-effective analytical device for performing immunoassays with ultra high sensitivity
WO2002064842A2 (en) 2001-02-13 2002-08-22 Children`S Hospital Research Foundation Quantitative epstein barr virus pcr rapid assay
AU2002230290B2 (en) * 2001-02-16 2008-04-10 Pepscan Systems B.V. Arrays for determining binding of biomolecules
AU2002245537B2 (en) 2001-02-23 2007-12-20 Genicon Sciences Corporation Methods for providing extended dynamic range in analyte assays
US20050196785A1 (en) * 2001-03-05 2005-09-08 California Institute Of Technology Combinational array for nucleic acid analysis
JP2002262876A (ja) * 2001-03-07 2002-09-17 Ngk Insulators Ltd 高感度な核酸のハイブリダイゼーション方法、及びその方法を用いた遺伝子解析方法
AU2002258502A1 (en) 2001-03-12 2002-09-24 Affymetrix, Inc. Nucleic acid labeling compounds
US6605438B1 (en) * 2001-03-26 2003-08-12 Louis Dischler Lyophilizing of liquid drops having arbitrary edges and application thereof to microarrays of biological reagents
US7419958B2 (en) 2001-03-26 2008-09-02 Dana-Farber Cancer Institute, Inc. Method of attenuating reactions to skin irritants
JP3937742B2 (ja) 2001-03-28 2007-06-27 キヤノン株式会社 プローブ担体及びその製造方法
JP2002286735A (ja) 2001-03-28 2002-10-03 Canon Inc プローブ担体製造用の液体吐出装置、プローブ担体の製造装置及びプローブ担体の製造方法
US20020142341A1 (en) * 2001-03-28 2002-10-03 Makoto Kameyama Method and apparatus for producing probe carrier
US6869551B2 (en) * 2001-03-30 2005-03-22 Picoliter Inc. Precipitation of solid particles from droplets formed using focused acoustic energy
US7604976B2 (en) 2001-04-02 2009-10-20 Ceres, Inc. Sequence-determined DNA fragments encoding glutamine amidotransferase proteins
US20020150944A1 (en) * 2001-04-06 2002-10-17 Fuji Photo Film Co., Ltd. Biochemical analysis unit and method for exposing stimulable phosphor sheet using the same
US6960437B2 (en) 2001-04-06 2005-11-01 California Institute Of Technology Nucleic acid amplification utilizing microfluidic devices
US20060129329A1 (en) * 2001-04-09 2006-06-15 Kobylecki Ryszard J Investigating different physical and/or chemical forms of materials
WO2002084249A2 (en) 2001-04-10 2002-10-24 The Board Of Trustees Of The Leland Stanford Junior University Therapeutic and diagnostic uses of antibody specificity profiles
EP1493014A2 (en) 2001-04-11 2005-01-05 Burstein Technologies, Inc. Multi-parameter assays including analysis discs and methods relating thereto
US20020155587A1 (en) 2001-04-20 2002-10-24 Sequenom, Inc. System and method for testing a biological sample
EP1390468A4 (en) * 2001-04-23 2004-09-22 Elitra Pharmaceuticals Inc IDENTIFICATION OF ESSENTIAL GENES OF ASPERGILLUS FUMIGATUS AND METHOD OF USE
KR100777362B1 (ko) * 2001-05-08 2007-11-19 (주)바이오니아 생물학적 시료의 미세 배열을 위한 스팟팅 핀
US6852524B2 (en) 2001-04-27 2005-02-08 Canon Kabushiki Kaisha Probe carrier, probe fixing carrier and method of manufacturing the same
US6943036B2 (en) * 2001-04-30 2005-09-13 Agilent Technologies, Inc. Error detection in chemical array fabrication
AU2002340641A1 (en) * 2001-05-03 2002-11-18 Sigma-Genosys, Ltd. Methods for assembling protein microarrays
US7338805B2 (en) 2001-05-04 2008-03-04 Bio Merieux Labeling reagents, methods for synthesizing such reagents and methods for detecting biological molecules
KR100419002B1 (ko) * 2001-05-11 2004-02-14 (주)로봇앤드디자인 글래스 칩 자세조정 장치
US6558907B2 (en) 2001-05-16 2003-05-06 Corning Incorporated Methods and compositions for arraying nucleic acids onto a solid support
EP1267169B1 (en) 2001-05-21 2004-12-15 Fuji Photo Film Co., Ltd. Biochemical analysis unit and method for its production
WO2002094846A2 (en) * 2001-05-22 2002-11-28 Parallel Synthesis Technologies, Inc. Method for in situ, on-chip chemical synthesis
WO2002097111A2 (en) * 2001-05-29 2002-12-05 Genomic Solutions, Inc. Method and apparatus for facilitating the creation and analysis of microarrays
WO2002099386A2 (en) * 2001-06-07 2002-12-12 Proligo Llc Microcalorimetric detection of analytes and binding events
US7026121B1 (en) 2001-06-08 2006-04-11 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US7235358B2 (en) 2001-06-08 2007-06-26 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US6905827B2 (en) 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
US20020192657A1 (en) * 2001-06-19 2002-12-19 Erwin Robert L. Bio-tolerant substrata having analyte binding microarray
US7041257B2 (en) * 2001-09-25 2006-05-09 Cytonome, Inc. Microfabricated two-pin liquid sample dispensing system
DE60221987T2 (de) 2001-06-22 2008-05-15 Stemcells, Inc., Palo Alto Le-zellen (liver engrafting cells), assays und verwendungen davon
US7402286B2 (en) * 2001-06-27 2008-07-22 The Regents Of The University Of California Capillary pins for high-efficiency microarray printing device
US6855538B2 (en) * 2001-06-27 2005-02-15 The Regents Of The University Of California High-efficiency microarray printing device
US7297480B2 (en) * 2001-06-28 2007-11-20 Dermtech International Method for detection of melanoma
US20030003493A1 (en) * 2001-07-02 2003-01-02 Fuji Photo Film Co., Ltd. Biochemical analysis unit and biochemical analysis kit
US6485918B1 (en) 2001-07-02 2002-11-26 Packard Bioscience Corporation Method and apparatus for incubation of a liquid reagent and target spots on a microarray substrate
US6989267B2 (en) * 2001-07-02 2006-01-24 Agilent Technologies, Inc. Methods of making microarrays with substrate surfaces having covalently bound polyelectrolyte films
US6753145B2 (en) * 2001-07-05 2004-06-22 Agilent Technologies, Inc. Buffer composition and method for hybridization of microarrays on adsorbed polymer siliceous surfaces
CA2656209C (en) * 2001-07-11 2012-11-27 Baylor College Of Medicine Methods and devices based upon a novel form of nucleic acid duplex on a surface
US10272409B2 (en) 2001-07-11 2019-04-30 Michael E. Hogan Methods and devices based upon a novel form of nucleic acid duplex on a surface
US20030013208A1 (en) * 2001-07-13 2003-01-16 Milagen, Inc. Information enhanced antibody arrays
WO2003008941A2 (en) * 2001-07-17 2003-01-30 Bioforce Nanosciences, Inc. Combined molecular blinding detection through force microscopy and mass spectrometry
US7402282B2 (en) 2001-07-20 2008-07-22 Ortho-Clinical Diagnostics, Inc. Auxiliary sample supply for a clinical analyzer
US20040006033A1 (en) * 2001-08-06 2004-01-08 Zhu York Yuan-Yuan Methods for identifying low-abundance polynucleotides and related compositions
US6787312B2 (en) * 2001-08-09 2004-09-07 Corning Incorporated Treatment of substrates for immobilizing biomolecules
EP1453600A1 (en) * 2001-08-10 2004-09-08 Oxford Genome Sciences (UK) Limited Liquid delivery apparatus and method
US20050019223A1 (en) * 2001-08-10 2005-01-27 Platt Albert Edward Liquid delivery apparatus and method
US20030040129A1 (en) * 2001-08-20 2003-02-27 Shah Haresh P. Binding assays using magnetically immobilized arrays
CA2457474A1 (en) * 2001-08-21 2003-03-06 Mcw Research Foundation, Inc. Method and apparatus for three label microarrays
US7014744B2 (en) 2001-08-24 2006-03-21 Applera Corporation Method of purification and concentration using AC fields with a transfer tip
JP4723133B2 (ja) * 2001-08-24 2011-07-13 千葉県 新規ヒトｂｍｃｃ１遺伝子
JP2003135063A (ja) * 2001-08-24 2003-05-13 Chiba Prefecture 新規な遺伝子ｎｅｄｌ−１
US6969489B2 (en) 2001-08-24 2005-11-29 Cytoplex Biosciences Micro array for high throughout screening
US20030087309A1 (en) * 2001-08-27 2003-05-08 Shiping Chen Desktop drug screening system
WO2003020898A2 (en) * 2001-08-30 2003-03-13 Spectral Genomics, Inc. Arrays comprising pre-labeled biological molecules and methods for making and using these arrays
CA2356540A1 (en) * 2001-08-30 2003-02-28 Emory University Expressed dna sequences involved in mitochondrial functions
US20040151627A1 (en) * 2001-08-30 2004-08-05 Nelson Mary Anne Methods for covalently attaching nucleic acids to substrates
US20050123913A1 (en) * 2001-08-30 2005-06-09 Emory University Human mitochondrial dna polymorphisms, haplogroups, associations with physiological conditions, and genotyping arrays
US20030129665A1 (en) * 2001-08-30 2003-07-10 Selvan Gowri Pyapali Methods for qualitative and quantitative analysis of cells and related optical bio-disc systems
WO2003021222A2 (en) * 2001-08-31 2003-03-13 Burstein Technologies, Inc. Capture layer assemblies for cellular assays including related optical analysis discs and methods
US20050147984A1 (en) * 2001-08-31 2005-07-07 Clondiag Chip Technologies Gmbh Interaction detection on several probe arrays
AU2002335715A1 (en) * 2001-09-07 2003-03-24 Burstein Technologies, Inc. Optical bio-disc systems for nuclear morphology based identification
WO2003023409A2 (en) * 2001-09-07 2003-03-20 Transform Pharmaceuticals, Inc. Apparatus and method for high-throughput preparation and characterization of compositions
US6955788B2 (en) * 2001-09-07 2005-10-18 Affymetrix, Inc. Apparatus and method for aligning microarray printing head
CA2459893C (en) * 2001-09-10 2014-01-21 Meso Scale Technologies, Llc Methods and apparatus for conducting multiple measurements on a sample
US6974671B1 (en) 2001-09-12 2005-12-13 Salk Institute For Biological Studies Methods for indentifying compounds that modulate gluconeogenesis through the binding of CREB to the PGC-1 promoter
EP1434993B1 (en) 2001-09-18 2013-04-24 Fibrogen, Inc. Methods of assaying connective tissue growth factor
US6670129B2 (en) 2001-09-24 2003-12-30 Corning Incorporated Cell transfection apparatus and methods for making and using the cell transfection apparatus
US20070054408A1 (en) * 2001-09-25 2007-03-08 Cytonome, Inc. Microfabricated two-pin system for biomolecule crystallization
KR100443641B1 (ko) * 2001-09-25 2004-08-09 김흥기 디엔에이 함침 핀의 제조방법
US7153699B2 (en) * 2001-12-21 2006-12-26 Cytonome, Inc. Microfabricated two-pin system for biomolecule crystallization
US7042488B2 (en) 2001-09-27 2006-05-09 Fujinon Corporation Electronic endoscope for highlighting blood vessel
AU2002334887A1 (en) * 2001-10-05 2003-04-22 Vanderbilt University Capillary tube printing tips for microarray printing
US7439346B2 (en) 2001-10-12 2008-10-21 Perkinelmer Las Inc. Nucleic acids arrays and methods of use therefor
AU2002367886B8 (en) 2001-10-12 2008-08-14 Perkinelmer Las, Inc. Compilations of nucleic acids and arrays and methods of using them
US20040029129A1 (en) * 2001-10-25 2004-02-12 Liangsu Wang Identification of essential genes in microorganisms
US8440093B1 (en) 2001-10-26 2013-05-14 Fuidigm Corporation Methods and devices for electronic and magnetic sensing of the contents of microfluidic flow channels
US20030082560A1 (en) * 2001-10-29 2003-05-01 Yingjian Wang Method of making interactive protein arrays
US20030082294A1 (en) * 2001-10-31 2003-05-01 Laurakay Bruhn Surface treatment method for bio-arrays
US6866825B2 (en) 2001-11-05 2005-03-15 Industrial Technology Research Institute Micro-dispenser for biochemical analysis
AU2002360361A1 (en) * 2001-11-09 2003-06-10 Biomicroarrays, Inc. High surface area substrates for microarrays and methods to make same
ES2345329T3 (es) * 2001-11-09 2010-09-21 Georgetown University Nueva isoforma del inhibidor del crecimiento celular endotelial vascular (vegi).
WO2003042697A1 (en) * 2001-11-14 2003-05-22 Genospectra, Inc. Biochemical analysis system with combinatorial chemistry applications
WO2003044484A2 (en) * 2001-11-16 2003-05-30 Sloan-Kettering Institute For Cancer Research High-density cell microarrays for parallel functional determinations
WO2003044481A2 (en) * 2001-11-20 2003-05-30 Burstein Technologies, Inc. Optical bio-discs and microfluidic devices for analysis of cells
JP2005509870A (ja) * 2001-11-20 2005-04-14 ジェネンテック・インコーポレーテッド 細胞及び組織アレイ及びマイクロアレイと使用方法
US7691333B2 (en) 2001-11-30 2010-04-06 Fluidigm Corporation Microfluidic device and methods of using same
EP1463796B1 (en) 2001-11-30 2013-01-09 Fluidigm Corporation Microfluidic device and methods of using same
WO2003048727A2 (en) * 2001-12-03 2003-06-12 Invitrogen Corporation Identification of rearrangements in nucleic acid molecules
EP2295060B1 (en) 2001-12-06 2018-10-31 Fibrogen, Inc. Treatment or prevention of ischemic or hypoxic conditions
ES2414706T3 (es) 2001-12-06 2013-07-22 Fibrogen, Inc. Métodos para aumentar la eritropoyetina endógena
US20070037147A1 (en) * 2001-12-07 2007-02-15 Pablo Garcia Endogenous retrovirus polypeptides linked to oncogenic transformation
ATE526041T1 (de) 2001-12-11 2011-10-15 Fibrogen Inc Verfahren zur hemmung okularer vorgänge
US7258839B2 (en) * 2001-12-21 2007-08-21 Cytonome, Inc. Temperature controlled microfabricated two-pin liquid sample dispensing system
US20030170694A1 (en) * 2001-12-21 2003-09-11 Daniel Wall Stabilized nucleic acids in gene and drug discovery and methods of use
US6846454B2 (en) * 2001-12-24 2005-01-25 Agilent Technologies, Inc. Fluid exit in reaction chambers
US20030124542A1 (en) * 2001-12-28 2003-07-03 Spectral Genomics, Inc. Methods for mapping the chromosomal loci of genes expressed by a cell
FR2834521B1 (fr) * 2002-01-10 2004-12-17 Bio Merieux Procede de detection et/ou d'identification de l'espece animale d'origine de la matiere animale contenue dans un echantillon
US20030148391A1 (en) * 2002-01-24 2003-08-07 Salafsky Joshua S. Method using a nonlinear optical technique for detection of interactions involving a conformational change
US20030143329A1 (en) * 2002-01-30 2003-07-31 Shchegrova Svetlana V. Error correction in array fabrication
EP1333285B1 (en) 2002-01-31 2005-03-30 Fuji Photo Film Co., Ltd. Biochemical analysis unit and method for producing thereof
KR100969209B1 (ko) * 2002-01-31 2010-07-09 후지필름 가부시키가이샤 생화학분석용 유니트의 제조방법
US7378492B2 (en) * 2002-02-20 2008-05-27 Incyte Corporation CD40-related receptor that binds CD40L
WO2003072752A2 (en) * 2002-02-27 2003-09-04 Miragene, Inc. Improved substrate chemistry for protein immobilization on a rigid support
US20030161761A1 (en) * 2002-02-28 2003-08-28 Williams Roger O. Apparatus and method for composing high density materials onto target substrates by a rapid sequence
DE10229253A1 (de) * 2002-06-28 2004-01-29 Axaron Bioscience Ag Aufbringen eines Stoffs auf ein Substrat
WO2003076076A2 (de) * 2002-03-11 2003-09-18 Axaron Bioscience Ag Aufbringen eines stoffs auf ein substrat
US20060099142A1 (en) * 2002-03-14 2006-05-11 Delaney Allen D Cancer associated araf1 protein kinase and its uses
US20040241723A1 (en) * 2002-03-18 2004-12-02 Marquess Foley Leigh Shaw Systems and methods for improving protein and milk production of dairy herds
EP2093233A1 (en) 2002-03-21 2009-08-26 Sagres Discovery, Inc. Novel compositions and methods in cancer
US6919531B2 (en) * 2002-03-25 2005-07-19 Agilent Technologies, Inc. Methods for producing glass substrates for use in biopolymeric microarrays
US6916621B2 (en) * 2002-03-27 2005-07-12 Spectral Genomics, Inc. Methods for array-based comparitive binding assays
WO2003085379A2 (en) 2002-04-01 2003-10-16 Fluidigm Corporation Microfluidic particle-analysis systems
US20040029151A1 (en) * 2002-04-09 2004-02-12 Affymetrix, Inc. Molecular genetic profiling of gleason grades 3 and 4/5 prostate cancer
US7687256B2 (en) * 2002-04-11 2010-03-30 Spire Corporation Surface activated biochip
CA2481411C (en) 2002-04-19 2016-06-14 Diversa Corporation Phospholipases, nucleic acids encoding them and methods for making and using them
US7226771B2 (en) 2002-04-19 2007-06-05 Diversa Corporation Phospholipases, nucleic acids encoding them and methods for making and using them
KR100456213B1 (ko) * 2002-05-02 2004-11-09 주식회사 가이아모 시료배열장치용 초미세 인쇄용 펜
US20040072274A1 (en) * 2002-05-09 2004-04-15 Lebrun Stewart J. System and method for visualization and digital analysis of protein and other macromolecule microarrays
US6841379B2 (en) 2002-05-15 2005-01-11 Beckman Coulter, Inc. Conductive microplate
JP3732457B2 (ja) * 2002-05-20 2006-01-05 日立ソフトウエアエンジニアリング株式会社 スポットピン
TWI221523B (en) * 2002-05-21 2004-10-01 Sony Corp Bioassay method, bioassay device, and bioassay substrate
US6980677B2 (en) * 2002-05-24 2005-12-27 Niles Scientific, Inc. Method, system, and computer code for finding spots defined in biological microarrays
US7273589B2 (en) * 2002-05-28 2007-09-25 Pss Bio Instruments, Inc. Samples delivering device, method of manufacturing samples applicator, method of delivering samples, and base activation device
JP2005527614A (ja) 2002-05-29 2005-09-15 デヴェロゲン アクチエンゲゼルシャフト フュア エントヴィックルングスビオローギッシェ フォルシュング 膵臓特異性タンパク質
US20050239193A1 (en) * 2002-05-30 2005-10-27 Bioforce Nanosciences, Inc. Device and method of use for detection and characterization of microorganisms and microparticles
US7537936B2 (en) * 2002-05-31 2009-05-26 Agilent Technologies, Inc. Method of testing multiple fluid samples with multiple biopolymer arrays
US20040031167A1 (en) 2002-06-13 2004-02-19 Stein Nathan D. Single wafer method and apparatus for drying semiconductor substrates using an inert gas air-knife
US8518694B2 (en) * 2002-06-13 2013-08-27 Novartis Vaccines And Diagnostics, Inc. Nucleic acid vector comprising a promoter and a sequence encoding a polypeptide from the endogenous retrovirus PCAV
US7919308B2 (en) * 2002-06-14 2011-04-05 Agilent Technologies, Inc. Form in place gaskets for assays
EP1375678A3 (en) * 2002-06-14 2004-03-10 Agilent Technologies, Inc. Methods and compositions for performing array based assays
US9068173B2 (en) 2002-06-17 2015-06-30 Ceres, Inc. Sequence-determined DNA fragments encoding trehalose-6P phosphatase proteins
US20030231986A1 (en) * 2002-06-18 2003-12-18 Eastman Kodak Company Micro-array identification means
USH2223H1 (en) 2002-07-11 2008-09-02 The United States Of America As Represented By The Secretary Of The Navy Patterned, micrometer-sized antibody features
DE10329928A1 (de) * 2002-07-12 2004-02-05 Benq Corp., Kweishan Verfahren zur Aufbereitung von Biochips und Biochip
JP2004045346A (ja) * 2002-07-16 2004-02-12 Nisshinbo Ind Inc マイクロアレイの作製方法
AU2003261168A1 (en) * 2002-07-19 2004-02-09 Althea Technologies, Inc. Strategies for gene expression analysis
US20040018497A1 (en) * 2002-07-26 2004-01-29 Warden Craig H Human obesity LIPIN3 polynucleotide and polypeptide sequences and methods of use thereof
US7105347B2 (en) * 2002-07-30 2006-09-12 Corning Incorporated Method and device for protein delivery into cells
WO2004015396A2 (en) * 2002-08-13 2004-02-19 Incyte Corporation Cell adhesion and extracellular matrix proteins
AU2003255253A1 (en) * 2002-08-13 2004-02-25 Discovery Partners International Spotting pattern for placement of compounds in an array
WO2004016802A2 (en) * 2002-08-15 2004-02-26 Proteoplex, Inc. Methods and apparatus for preparing and assaying biological samples to determine protein concentration
US7384742B2 (en) * 2002-08-16 2008-06-10 Decision Biomarkers, Inc. Substrates for isolating reacting and microscopically analyzing materials
US20030036085A1 (en) * 2002-08-19 2003-02-20 Salinaro Richard F Membranes
US8277753B2 (en) 2002-08-23 2012-10-02 Life Technologies Corporation Microfluidic transfer pin
EP1548105A4 (en) * 2002-08-30 2006-03-01 Japan Science & Tech Agency TARGETED GENE DISRUPTION METHOD, HYPERTHERMOSTABLE BACTERIUM GENOME AND GENOMIC CHIP USING SUCH A METHOD
US20070219353A1 (en) * 2002-09-03 2007-09-20 Incyte Corporation Immune Response Associated Proteins
US7595883B1 (en) * 2002-09-16 2009-09-29 The Board Of Trustees Of The Leland Stanford Junior University Biological analysis arrangement and approach therefor
US20040054160A1 (en) * 2002-09-16 2004-03-18 Santona Pal Nucleic-acid ink compositions for arraying onto a solid support
CA2503905A1 (en) * 2002-09-16 2004-03-25 Plexxikon, Inc. Crystal structure of pim-1 kinase
US7329545B2 (en) * 2002-09-24 2008-02-12 Duke University Methods for sampling a liquid flow
US6989234B2 (en) * 2002-09-24 2006-01-24 Duke University Method and apparatus for non-contact electrostatic actuation of droplets
US6911132B2 (en) 2002-09-24 2005-06-28 Duke University Apparatus for manipulating droplets by electrowetting-based techniques
US7143785B2 (en) 2002-09-25 2006-12-05 California Institute Of Technology Microfluidic large scale integration
US7997288B2 (en) * 2002-09-30 2011-08-16 Lam Research Corporation Single phase proximity head having a controlled meniscus for treating a substrate
US7153400B2 (en) * 2002-09-30 2006-12-26 Lam Research Corporation Apparatus and method for depositing and planarizing thin films of semiconductor wafers
US7093375B2 (en) * 2002-09-30 2006-08-22 Lam Research Corporation Apparatus and method for utilizing a meniscus in substrate processing
US7367345B1 (en) 2002-09-30 2008-05-06 Lam Research Corporation Apparatus and method for providing a confined liquid for immersion lithography
US7632376B1 (en) 2002-09-30 2009-12-15 Lam Research Corporation Method and apparatus for atomic layer deposition (ALD) in a proximity system
US7293571B2 (en) * 2002-09-30 2007-11-13 Lam Research Corporation Substrate proximity processing housing and insert for generating a fluid meniscus
US7069937B2 (en) * 2002-09-30 2006-07-04 Lam Research Corporation Vertical proximity processor
US7045018B2 (en) * 2002-09-30 2006-05-16 Lam Research Corporation Substrate brush scrubbing and proximity cleaning-drying sequence using compatible chemistries, and method, apparatus, and system for implementing the same
US6988326B2 (en) * 2002-09-30 2006-01-24 Lam Research Corporation Phobic barrier meniscus separation and containment
US7389783B2 (en) * 2002-09-30 2008-06-24 Lam Research Corporation Proximity meniscus manifold
US7614411B2 (en) * 2002-09-30 2009-11-10 Lam Research Corporation Controls of ambient environment during wafer drying using proximity head
US7513262B2 (en) * 2002-09-30 2009-04-07 Lam Research Corporation Substrate meniscus interface and methods for operation
US7240679B2 (en) * 2002-09-30 2007-07-10 Lam Research Corporation System for substrate processing with meniscus, vacuum, IPA vapor, drying manifold
US6988327B2 (en) 2002-09-30 2006-01-24 Lam Research Corporation Methods and systems for processing a substrate using a dynamic liquid meniscus
US7383843B2 (en) * 2002-09-30 2008-06-10 Lam Research Corporation Method and apparatus for processing wafer surfaces using thin, high velocity fluid layer
US8236382B2 (en) * 2002-09-30 2012-08-07 Lam Research Corporation Proximity substrate preparation sequence, and method, apparatus, and system for implementing the same
US6954993B1 (en) 2002-09-30 2005-10-18 Lam Research Corporation Concentric proximity processing head
WO2004031351A2 (en) * 2002-10-01 2004-04-15 Nimblegen Systems, Inc. Microarrays having multiple oligonucleotides in single array features
WO2004040001A2 (en) 2002-10-02 2004-05-13 California Institute Of Technology Microfluidic nucleic acid analysis
AU2003279829A1 (en) * 2002-10-04 2004-05-04 Incyte Corp Protein modification and maintenance molecules
US20040067492A1 (en) * 2002-10-04 2004-04-08 Allan Peng Reverse transcription on microarrays
US20040235005A1 (en) * 2002-10-23 2004-11-25 Ernest Friedlander Methods and composition for detecting targets
US20040089750A1 (en) * 2002-10-23 2004-05-13 Muniswamappa Anjanappa Micro-array fluid dispensing apparatus and method
US20040082058A1 (en) * 2002-10-29 2004-04-29 Arthur Schleifer Array hybridization apparatus and method for making uniform sample volumes
US20040086868A1 (en) * 2002-10-30 2004-05-06 Parker Russell A. Enclosed arrays and their reading
US20030153013A1 (en) * 2002-11-07 2003-08-14 Ruo-Pan Huang Antibody-based protein array system
AU2002952696A0 (en) 2002-11-14 2002-11-28 Genomics Research Partners Pty Ltd Status determination
EP1579005A4 (en) * 2002-11-15 2007-07-25 Sangamo Biosciences Inc METHOD AND COMPOSITIONS FOR THE ANALYSIS OF REGULATORY SEQUENCES
AU2003302234A1 (en) * 2002-11-26 2004-06-18 Incyte Corporation Immune response associated proteins
CN1774511B (zh) 2002-11-27 2013-08-21 斯昆诺有限公司 用于序列变异检测和发现的基于断裂的方法和系统
US20040109045A1 (en) * 2002-12-06 2004-06-10 Eastman Kodak Company Print head for micro-deposition of bio-molecules
EP1572227B1 (en) 2002-12-16 2012-02-15 DeveloGen Aktiengesellschaft Pik4cb involved in the regulation of energy homeostasis
US7247337B1 (en) 2002-12-16 2007-07-24 Agilent Technologies, Inc. Method and apparatus for microarray fabrication
US20040121339A1 (en) * 2002-12-19 2004-06-24 Jizhong Zhou Special film-coated substrate for bio-microarray fabrication and use thereof
US20040120859A1 (en) * 2002-12-20 2004-06-24 Kocher Thomas E. Biomolecular micro-deposition system
JP5479663B2 (ja) 2002-12-20 2014-04-23 セレラ コーポレーション 心筋梗塞に関連する遺伝的多型、その検出方法および使用
AU2003302264A1 (en) 2002-12-20 2004-09-09 Biotrove, Inc. Assay apparatus and method using microfluidic arrays
US7323555B2 (en) 2002-12-26 2008-01-29 Isao Saito Nucleotide derivative and DNA microarray
US7414117B2 (en) 2002-12-26 2008-08-19 Ngk Insulators, Ltd. Nucleotide derivative and DNA microarray
US20030166263A1 (en) * 2002-12-30 2003-09-04 Haushalter Robert C. Microfabricated spotting apparatus for producing low cost microarrays
KR20050100367A (ko) * 2003-01-02 2005-10-18 바이오포스 나노사이언스, 인크. 소용적 샘플 내의 분자 분석용 방법 및 장치
US7029855B1 (en) * 2003-01-28 2006-04-18 Proteomyx Inc. Radioactive multiplexing analytical methods for biomarkers discovery
US7691580B2 (en) * 2003-01-29 2010-04-06 Corning Incorporated Reverse protein delivery into cells on coded microparticles
US20040151635A1 (en) * 2003-01-31 2004-08-05 Leproust Eric M. Array fabrication using deposited drop splat size
US20040152083A1 (en) * 2003-01-31 2004-08-05 Leproust Eric M. Multiple arrays with surface energy transition to maintain separation of samples on the arrays
US20040152081A1 (en) * 2003-01-31 2004-08-05 Leproust Eric M. Viscosity control during polynucleotide synthesis
US20050048573A1 (en) * 2003-02-03 2005-03-03 Plexxikon, Inc. PDE5A crystal structure and uses
US20070149449A1 (en) 2003-02-14 2007-06-28 Morris David W Therapeutic targets in cancer
US7767387B2 (en) 2003-06-13 2010-08-03 Sagres Discovery, Inc. Therapeutic targets in cancer
US6861251B2 (en) * 2003-02-24 2005-03-01 Pritest, Inc. Translucent solid matrix assay device for microarray analysis
WO2004078923A2 (en) * 2003-02-28 2004-09-16 Plexxikon, Inc. Pyk2 crystal structure and uses
US20040233250A1 (en) * 2003-03-05 2004-11-25 Haushalter Robert C. Microcontact printhead device
EP3508578A1 (en) 2003-03-06 2019-07-10 BASF Enzymes, LLC Amylases, nucleic acids encoding them and methods for making and using them
DK2853593T3 (en) 2003-03-07 2018-01-08 Dsm Ip Assets Bv Hydrolases, nucleic acids encoding them, and processes for their preparation and use
EP1606419A1 (en) 2003-03-18 2005-12-21 Quantum Genetics Ireland Limited Systems and methods for improving protein and milk production of dairy herds
DE10312628A1 (de) * 2003-03-21 2004-10-07 Friz Biochem Gmbh Verfahren und Vorrichtung zum Benetzen eines Substrats mit einer Flüssigkeit
WO2004087323A1 (en) * 2003-03-28 2004-10-14 Mergen Ltd. Multi-array systems and methods of use thereof
US8828663B2 (en) 2005-03-18 2014-09-09 Fluidigm Corporation Thermal reaction device and method for using the same
US7476363B2 (en) 2003-04-03 2009-01-13 Fluidigm Corporation Microfluidic devices and methods of using same
US20050145496A1 (en) 2003-04-03 2005-07-07 Federico Goodsaid Thermal reaction device and method for using the same
US7604965B2 (en) 2003-04-03 2009-10-20 Fluidigm Corporation Thermal reaction device and method for using the same
US7666361B2 (en) 2003-04-03 2010-02-23 Fluidigm Corporation Microfluidic devices and methods of using same
WO2004090099A2 (en) 2003-04-04 2004-10-21 Diversa Corporation Pectate lyases, nucleic acids encoding them and methods for making and using them
US7025935B2 (en) * 2003-04-11 2006-04-11 Illumina, Inc. Apparatus and methods for reformatting liquid samples
US8652774B2 (en) * 2003-04-16 2014-02-18 Affymetrix, Inc. Automated method of manufacturing polyer arrays
US7892745B2 (en) 2003-04-24 2011-02-22 Xdx, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US20040214310A1 (en) * 2003-04-25 2004-10-28 Parker Russell A. Apparatus and method for array alignment
EP1623010A4 (en) * 2003-04-25 2007-12-26 Janssen Pharmaceutica Nv PRESERVATION OF RNA IN A BIOLOGICAL SAMPLE
US7829682B1 (en) 2003-04-30 2010-11-09 Incyte Corporation Human β-adrenergic receptor kinase nucleic acid molecule
US20050025763A1 (en) 2003-05-08 2005-02-03 Protein Design Laboratories, Inc. Therapeutic use of anti-CS1 antibodies
US7709610B2 (en) 2003-05-08 2010-05-04 Facet Biotech Corporation Therapeutic use of anti-CS1 antibodies
US20040223890A1 (en) * 2003-05-09 2004-11-11 Summers Douglas G. Clamshell slide holder
EP1623020A4 (en) * 2003-05-09 2007-05-09 Sigma Aldrich Co GENOMIC AND PROTEOMIC APPROACHES FOR THE DEVELOPMENT OF CELL CULTURE MEDIA
US8150627B2 (en) 2003-05-15 2012-04-03 Illumina, Inc. Methods and compositions for diagnosing lung cancer with specific DNA methylation patterns
US8150626B2 (en) * 2003-05-15 2012-04-03 Illumina, Inc. Methods and compositions for diagnosing lung cancer with specific DNA methylation patterns
KR101126845B1 (ko) 2003-05-19 2012-03-28 도레이 카부시키가이샤 선택 결합성 물질 고정화 담체
US20040241659A1 (en) * 2003-05-30 2004-12-02 Applera Corporation Apparatus and method for hybridization and SPR detection
FR2855832B1 (fr) * 2003-06-03 2007-09-14 Biomerieux Sa Procede de diagnostic et/ou de pronostic d'un syndrome septique
WO2005001129A2 (en) * 2003-06-06 2005-01-06 Applera Corporation Mobility cassettes
US20040248323A1 (en) 2003-06-09 2004-12-09 Protometrix, Inc. Methods for conducting assays for enzyme activity on protein microarrays
US20070025880A1 (en) * 2003-06-17 2007-02-01 Moussa Hoummady Device for removing and depositing droplets of at least one liquid, method of using the device and servo system for said method
CN1809751B (zh) 2003-06-20 2011-08-24 环球生物研究株式会社 试样排列集积化装置和方法
US20040259261A1 (en) * 2003-06-20 2004-12-23 Phalanx Biotech Group, Inc. Method for manufacturing a microarray and verifying the same
US20040259100A1 (en) 2003-06-20 2004-12-23 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
US7675000B2 (en) * 2003-06-24 2010-03-09 Lam Research Corporation System method and apparatus for dry-in, dry-out, low defect laser dicing using proximity technology
US7960148B2 (en) 2003-07-02 2011-06-14 Verenium Corporation Glucanases, nucleic acids encoding them and methods for making and using them
WO2005003769A1 (ja) * 2003-07-04 2005-01-13 Kubota Corporation バイオチップ
US20050079548A1 (en) * 2003-07-07 2005-04-14 Plexxikon, Inc. Ligand development using PDE4B crystal structures
JP2005030869A (ja) * 2003-07-10 2005-02-03 Fuji Photo Film Co Ltd プローブ溶液の点着方法
FR2857375B1 (fr) * 2003-07-10 2007-11-09 Biomerieux Sa Procede de detection et/ou d'identification de bacteries de genre staphylococcus
WO2005005471A2 (en) 2003-07-11 2005-01-20 Develogen Aktiengesellschaft Use of dg153 secreted protein products for preventing and treating pancreatic diseases and/or obesity and/or metabolic syndrome
CA2537896C (en) 2003-07-14 2014-03-25 International Livestock Research Institute East coast fever vaccine based on ctl-specific schizont antigens
US20050048571A1 (en) * 2003-07-29 2005-03-03 Danielson Paul S. Porous glass substrates with reduced auto-fluorescence
US20050026304A1 (en) * 2003-07-30 2005-02-03 Laurakay Bruhn Microarray based affinity purification and analysis device coupled with secondary analysis technologies
DK1660680T3 (da) 2003-07-31 2009-06-22 Sequenom Inc Fremgangsmåde til multipleks-polymerasekædereaktioner på höjt niveau og homogene masseforlængelsesreaktioner til genotypebestemmelse af polymorfismer
US20050031488A1 (en) * 2003-08-06 2005-02-10 Hui Ge Sample array test slide with suspended membrane
EP1668111A4 (en) 2003-08-08 2008-07-02 Genenews Inc OSTEOARTHRITIS BIOMARKERS AND USES THEREOF
US7413712B2 (en) 2003-08-11 2008-08-19 California Institute Of Technology Microfluidic rotary flow reactor matrix
CA2535526C (en) 2003-08-11 2015-09-29 Diversa Corporation Laccases, nucleic acids encoding them and methods for making and using them
US20070026406A1 (en) * 2003-08-13 2007-02-01 Iconix Pharmaceuticals, Inc. Apparatus and method for classifying multi-dimensional biological data
WO2005019811A2 (en) * 2003-08-26 2005-03-03 Blueshift Biotechnologies, Inc. Time dependent fluorescence measurements
JP2005077284A (ja) * 2003-09-01 2005-03-24 Seiko Epson Corp 粒子アレイの製造装置及び製造方法と標的物質の検出方法
US9394565B2 (en) 2003-09-05 2016-07-19 Agena Bioscience, Inc. Allele-specific sequence variation analysis
CA2536565A1 (en) * 2003-09-10 2005-05-12 Althea Technologies, Inc. Expression profiling using microarrays
US20050059083A1 (en) * 2003-09-15 2005-03-17 Becton Dickinson And Company High throughput method to identify ligands for cell attachment
WO2005028624A2 (en) * 2003-09-15 2005-03-31 Plexxikon, Inc. Molecular scaffolds for kinase ligand development
US20050060100A1 (en) * 2003-09-15 2005-03-17 Becton Dickinson And Company Computer software and algorithms for systems biologically linked to cellular phenotype
US20050282177A1 (en) * 2003-09-22 2005-12-22 Aichi Prefecture Types of lymphoma and method for prognosis thereof
US7601532B2 (en) * 2003-09-25 2009-10-13 Hisamitsu Pharmaceutical Co., Inc. Microarray for predicting the prognosis of neuroblastoma and method for predicting the prognosis of neuroblastoma
FR2860518B1 (fr) * 2003-10-01 2006-02-17 Biomerieux Sa Procede pour le diagnostic/pronostic du neuroblastome
JP2005114427A (ja) * 2003-10-03 2005-04-28 Sony Corp 二枚の基板を重ね合わせてバイオアッセイ用基板を製造する方法及びバイオアッセイ用基板
WO2005045056A2 (en) * 2003-10-07 2005-05-19 Nathaniel Tue Tran Radioactive multiplexing analytical methods
EP2322278B1 (en) * 2003-10-24 2017-01-04 Aushon Biosystems, Inc. Apparatus and Method for Dispensing Fluid, Semi-Solid and Solid Samples
US20070212689A1 (en) * 2003-10-30 2007-09-13 Bianchi Diana W Prenatal Diagnosis Using Cell-Free Fetal DNA in Amniotic Fluid
EP1689879A4 (en) * 2003-11-12 2008-08-27 Geneohm Sciences Inc METHODS OF HYBRIDIZING NUCLEIC ACID
FR2862239B1 (fr) * 2003-11-14 2007-11-23 Commissariat Energie Atomique Dispositif de reception d'un echantillon de fluide, et ses applications
EP1699939A4 (en) 2003-11-17 2008-07-02 Tm Bioscience Corp METHOD FOR DETECTING MUTATIONS ASSOCIATED WITH THROMBOSE
EP1694352A2 (en) 2003-11-19 2006-08-30 DeveloGen Aktiengesellschaft Use of secreted protein products for preventing and treating pancreatic diseases and/or obesity and/or metabolic syndrome
CA3048093A1 (en) 2003-11-26 2005-06-23 Celera Corporation Single nucleotide polymorphisms associated with cardiovascular disorders and statin response, methods of detection and uses thereof
EP1697534B1 (en) 2003-12-01 2010-06-02 Life Technologies Corporation Nucleic acid molecules containing recombination sites and methods of using the same
JP2005173484A (ja) * 2003-12-15 2005-06-30 Canon Inc 画像形成装置及びプロセスカートリッジ
EP1696920B8 (en) 2003-12-19 2015-05-06 Plexxikon Inc. Compounds and methods for development of ret modulators
US20070066641A1 (en) * 2003-12-19 2007-03-22 Prabha Ibrahim Compounds and methods for development of RET modulators
AU2004303448A1 (en) 2003-12-23 2005-07-07 Mount Sinai Hospital Methods for detecting markers associated with endometrial disease or phase
EP2287179A3 (en) 2004-01-09 2011-05-18 Novozymes A/S Increased bacillus YweA expression
US7670771B2 (en) 2004-01-21 2010-03-02 University Of Utah Research Foundation Mutant sodium channel Nav1.7 nucleic acid methods
US8017321B2 (en) 2004-01-23 2011-09-13 The Regents Of The University Of Colorado, A Body Corporate Gefitinib sensitivity-related gene expression and products and methods related thereto
US20050264805A1 (en) * 2004-02-09 2005-12-01 Blueshift Biotechnologies, Inc. Methods and apparatus for scanning small sample volumes
US20050202484A1 (en) 2004-02-19 2005-09-15 The Governors Of The University Of Alberta Leptin promoter polymorphisms and uses thereof
DK2096120T3 (da) 2004-02-20 2012-07-09 Develogen Ag Anvendelse af sekreterede proteinprodukter til at forebygge og behandle pankreatiske sygdomme og/eller obesitet og/eller metabolsk syndrom
US20050196761A1 (en) * 2004-03-08 2005-09-08 Thompson Allen C. Array hybridization apparatus and method
KR100590550B1 (ko) * 2004-03-12 2006-06-19 삼성전자주식회사 동일한 표적핵산에 결합하는 프로브 폴리뉴클레오티드사이의 거리가 최대가 되도록 배열되어 있는마이크로어레이 및 그를 제조하는 방법
JP2007529015A (ja) 2004-03-12 2007-10-18 バイオトローブ， インコーポレイテッド ナノリットルのアレイローディング
EP1729130B1 (en) * 2004-03-18 2011-10-05 Nissui Pharmaceutical Co., Ltd. Method of preparing analytical device and kit
JP4420020B2 (ja) * 2004-03-23 2010-02-24 東レ株式会社 溶液を攪拌する方法
FR2868071B1 (fr) * 2004-03-26 2006-06-09 Biomerieux Sa Reactifs de marquage, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques
US20050214930A1 (en) * 2004-03-26 2005-09-29 Bynum Magdalena A Apparatus and method for preventing cross contamination when dissassembling an array
US9249456B2 (en) 2004-03-26 2016-02-02 Agena Bioscience, Inc. Base specific cleavage of methylation-specific amplification products in combination with mass analysis
US7608394B2 (en) 2004-03-26 2009-10-27 Sequenom, Inc. Methods and compositions for phenotype identification based on nucleic acid methylation
JP2005283306A (ja) * 2004-03-29 2005-10-13 Lintec Corp プローブアレイ製造用部材及びプローブアレイの製造方法
CN104774931B (zh) 2004-03-31 2017-11-10 综合医院公司 测定癌症对表皮生长因子受体靶向性治疗反应性的方法
US7183057B2 (en) * 2004-03-31 2007-02-27 Dermtech International Tape stripping methods for analysis of skin disease and pathological skin state
US8062471B2 (en) * 2004-03-31 2011-11-22 Lam Research Corporation Proximity head heating method and apparatus
US20050227239A1 (en) * 2004-04-08 2005-10-13 Joyce Timothy H Microarray based affinity purification and analysis device coupled with solid state nanopore electrodes
US7384779B2 (en) * 2004-04-12 2008-06-10 Corning Incorporated Porous substrate plates and the use thereof
JP5273642B2 (ja) 2004-04-23 2013-08-28 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー ウイルスに対する細胞性の許容性因子、および該因子の使用
WO2006001896A2 (en) * 2004-04-26 2006-01-05 Iconix Pharmaceuticals, Inc. A universal gene chip for high throughput chemogenomic analysis
JP2007535681A (ja) * 2004-04-30 2007-12-06 バイオフォース・ナノサイエンシィズ・インコーポレーテッド 物質を表面上に堆積させるための方法と装置
DE102004021904B4 (de) * 2004-05-04 2011-08-18 Carl Zeiss Microlmaging GmbH, 07745 Verfahren und Vorrichtung zur Erzeugung einer Analyseanordnung mit diskreten, separaten Messbereichen zur biologischen, biochemischen oder chemischen Analyse
WO2006078287A2 (en) 2004-05-06 2006-07-27 Plexxikon, Inc. Pde4b inhibitors and uses therefor
US7820380B2 (en) 2004-05-07 2010-10-26 Celera Corporation Genetic polymorphisms associated with liver fibrosis
WO2005113834A2 (en) * 2004-05-20 2005-12-01 Quest Diagnostics Investments Incorporated Single label comparative hybridization
ES2537631T3 (es) 2004-05-27 2015-06-10 The Regents Of The University Of Colorado Métodos para la predicción del resultado clínico para inhibidores del receptor del factor de crecimiento epidérmico para pacientes de cáncer
EP1771563A2 (en) 2004-05-28 2007-04-11 Ambion, Inc. METHODS AND COMPOSITIONS INVOLVING MicroRNA
US7338763B2 (en) * 2004-06-02 2008-03-04 Eppendorf Array Technologies S.A. Method and kit for the detection and/or quantification of homologous nucleotide sequences on arrays
EP2527447A1 (en) 2004-06-03 2012-11-28 Athlomics Pty Ltd Agents and methods for diagnosing stress
WO2005124650A2 (en) * 2004-06-10 2005-12-29 Iconix Pharmaceuticals, Inc. Sufficient and necessary reagent sets for chemogenomic analysis
CN103173282A (zh) 2004-06-16 2013-06-26 帝斯曼知识产权资产管理有限公司 对叶绿素进行酶促脱色的组合物和方法
JP2008503473A (ja) * 2004-06-17 2008-02-07 プレキシコン，インコーポレーテッド Ｃ−ｋｉｔ活性を調節する化合物
US7498342B2 (en) * 2004-06-17 2009-03-03 Plexxikon, Inc. Compounds modulating c-kit activity
US7702466B1 (en) 2004-06-29 2010-04-20 Illumina, Inc. Systems and methods for selection of nucleic acid sequence probes
DE102004031177A1 (de) * 2004-06-29 2006-01-19 Henkel Kgaa Neue Geruchsstoffe bildende Genprodukte von Bacillus licheniformis und darauf aufbauende verbesserte biotechnologische Produktionsverfahren
ATE471991T1 (de) 2004-06-30 2010-07-15 Luminex Molecular Diagnostics Verfahren zum nachweis von mutationen im für cytochrom p450-2d6 codierenden gen
DE102004044179B4 (de) * 2004-06-30 2010-04-22 Osram Opto Semiconductors Gmbh Verfahren zur Montage von Halbleiterchips
US20060003345A1 (en) 2004-06-30 2006-01-05 Pfizer Inc RNA bioassay
WO2006014351A2 (en) * 2004-07-02 2006-02-09 Blueshift Biotechnologies, Inc. Exploring fluorophore microenvironments
JP2008506114A (ja) * 2004-07-06 2008-02-28 ユニバーシティー オブ ユタ リサーチ ファンデーション マイクロアレイおよび他のマイクロスケール装置上に高濃度スポットを沈着させるためのスポッティング装置および方法
US7588892B2 (en) * 2004-07-19 2009-09-15 Entelos, Inc. Reagent sets and gene signatures for renal tubule injury
US20060024677A1 (en) 2004-07-20 2006-02-02 Morris David W Novel therapeutic targets in cancer
EP2484780A1 (en) 2004-07-23 2012-08-08 The University of North Carolina At Chapel Hill Methods and materials for determining pain sensibility and predicting and treating related disorders
US20060105453A1 (en) 2004-09-09 2006-05-18 Brenan Colin J Coating process for microfluidic sample arrays
US12070731B2 (en) 2004-08-04 2024-08-27 Life Technologies Corporation Methods and systems for aligning dispensing arrays with microfluidic sample arrays
EP2292794A3 (en) 2004-08-06 2011-07-06 Genentech, Inc. Death receptor (DR) antibody for pharmaceutical use and assays employing biomarkers for predicting sensitivity of cells to said antibody
RU2431676C2 (ru) 2004-08-06 2011-10-20 Дженентек, Инк. Анализы и способы с применением биомаркеров
EP1623996A1 (en) * 2004-08-06 2006-02-08 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Improved method of selecting a desired protein from a library
EP1786813A2 (en) * 2004-09-03 2007-05-23 Plexxikon, Inc. Bicyclic heteroaryl pde4b inhibitors
US7645575B2 (en) 2004-09-08 2010-01-12 Xdx, Inc. Genes useful for diagnosing and monitoring inflammation related disorders
JP2006078356A (ja) * 2004-09-10 2006-03-23 Yokogawa Electric Corp バイオチップ作成装置
US20060059585A1 (en) 2004-09-14 2006-03-16 Boris Jankowski Modulating plant sugar levels
US20060108287A1 (en) * 2004-09-21 2006-05-25 Arnold Todd E Discrete zoned microporous nylon coated glass platform for use in microwell plates and methods of making and using same
US20060063274A1 (en) * 2004-09-23 2006-03-23 Schremp Donald J Methods for manufacturing and using chemical array calibration devices
WO2006037130A2 (en) * 2004-09-27 2006-04-06 Viagen, Inc. Method of targeted and comprehensive sequencing using high-density oligonucleotide array
FR2876116B1 (fr) * 2004-10-01 2007-04-06 Biomerieux Sa Methode pour generer des transcrits
US20060078896A1 (en) * 2004-10-12 2006-04-13 Peck Bill J Method, system, and computer program product to assess properties of a chemical array
FR2876705B1 (fr) * 2004-10-19 2008-12-12 Biomerieux Sa Procede pour le diagnostic d'une intolerance a l'aspirine
US20090118132A1 (en) * 2004-11-04 2009-05-07 Roche Molecular Systems, Inc. Classification of Acute Myeloid Leukemia
ES2534304T3 (es) 2004-11-12 2015-04-21 Asuragen, Inc. Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN
KR100624458B1 (ko) * 2005-01-17 2006-09-19 삼성전자주식회사 휴대용 원심분리기
ATE491941T1 (de) * 2005-01-27 2011-01-15 Quest Diagnostics Invest Inc Schnelle komparative genomhybridisierung
WO2006081558A2 (en) 2005-01-28 2006-08-03 Duke University Apparatuses and methods for manipulating droplets on a printed circuit board
FR2881437B1 (fr) 2005-01-31 2010-11-19 Biomerieux Sa Procede pour le diagnostic/pronostic d'un syndrome septique
WO2006086242A2 (en) 2005-02-07 2006-08-17 Genenews, Inc. Mild osteoarthritis biomarkers and uses thereof
US20060199207A1 (en) * 2005-02-24 2006-09-07 Matysiak Stefan M Self-assembly of molecules using combinatorial hybridization
WO2006094049A2 (en) * 2005-03-01 2006-09-08 Parallel Synthesis Technologies, Inc. Polymeric fluid transfer and printing devices
US20090038023A1 (en) 2005-03-10 2009-02-05 Verenium Corporation Lyase Enzymes, Nucleic Acids Encoding Them and Methods For Making and Using Them
WO2006099365A2 (en) 2005-03-11 2006-09-21 Applera Corporation Genetic polymorphisms associated with coronary heart disease, methods of detection and uses thereof
JP5343212B2 (ja) 2005-03-15 2013-11-13 ヴェレニウム コーポレイション セルラーゼ、それらをコードする核酸、並びにそれらを作製及び使用する方法
US20070092886A1 (en) * 2005-03-22 2007-04-26 Raymond Tabibiazar Methods and compositions for diagnosis, monitoring and development of therapeutics for treatment of atherosclerotic disease
US20080020941A1 (en) 2005-03-24 2008-01-24 Jimpei Tabata Biomolecule-immobilized plate and method for fabricating biomolecule-immobilized plate
EP1866443A4 (en) * 2005-04-04 2009-04-08 Blueshift Biotechnologies Inc SCREENING USING POLARIZATION ANISOTROPY IN FREIGHT EMISSIONS
CN101500481B (zh) 2005-04-05 2014-07-02 康宁股份有限公司 一种测定刺激事件对细胞产生的影响的方法
US20060246576A1 (en) 2005-04-06 2006-11-02 Affymetrix, Inc. Fluidic system and method for processing biological microarrays in personal instrumentation
JP2008535853A (ja) 2005-04-07 2008-09-04 ノバルティス ヴァクシンズ アンド ダイアグノスティクス インコーポレイテッド 癌関連遺伝子
WO2006110599A2 (en) 2005-04-07 2006-10-19 Novartis Vaccines And Diagnostics Inc. Cacna1e in cancer diagnosis, detection and treatment
EP1877559B1 (en) 2005-04-18 2010-10-13 Mitomics Inc. Mitochondrial mutations and rearrangements as a diagnostic tool for the detection of sun exposure, prostate cancer and other cancers
NZ563444A (en) * 2005-05-17 2011-04-29 Plexxikon Inc Pyrrolo(2,3-b)pyridine derivatives as protein kinase inhibitors
US8263414B2 (en) * 2005-05-23 2012-09-11 Siemens Healthcare Diagnostics Inc. Dispensing of a diagnostic liquid onto a diagnostic reagent
US7709197B2 (en) 2005-06-15 2010-05-04 Callida Genomics, Inc. Nucleic acid analysis by random mixtures of non-overlapping fragments
US20060286548A1 (en) * 2005-06-16 2006-12-21 Gregory Liposky Method of making recombinant human antibodies for use in biosensor technology
NZ565255A (en) * 2005-06-22 2010-04-30 Plexxikon Inc Pyrrolo[2,3-b] pyridine derivatives as protein kinase inhibitors
US20060292559A1 (en) * 2005-06-23 2006-12-28 Beckman Coulter, Inc. Cell-based microarrays, and methods for their preparation and use
EP1910565A4 (en) 2005-07-07 2009-10-28 Athlomics Pty Ltd POLYNUCLEOTIDE MARKER GENES AND THEIR EXPRESSION IN THE DIAGNOSIS OF ENDOTOXEMIA
CN1908189A (zh) * 2005-08-02 2007-02-07 博奥生物有限公司 体外辅助鉴定肠型胃癌及其分化程度的方法与专用试剂盒
ES2383966T3 (es) 2005-08-05 2012-06-27 Genentech, Inc. Métodos y composiciones para detectar trastornos autoinmunes
EP1915626B1 (en) 2005-08-16 2011-11-09 Genentech, Inc. Apoptosis sensitivity to apo2l/trail by testing for galnac-t14 expression in cells/tissues
ATE526398T1 (de) * 2005-08-19 2011-10-15 Commw Scient Ind Res Org Arachnocampa-luciferasen
US20070047388A1 (en) * 2005-08-25 2007-03-01 Rockwell Scientific Licensing, Llc Fluidic mixing structure, method for fabricating same, and mixing method
US7799530B2 (en) 2005-09-23 2010-09-21 Celera Corporation Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof
US8383059B2 (en) 2005-09-30 2013-02-26 University Of Utah Research Foundation Microfluidic interface for highly parallel addressing of sensing arrays
WO2007047408A2 (en) * 2005-10-12 2007-04-26 Pathologica, Llc. Promac signature application
WO2007053732A2 (en) 2005-11-01 2007-05-10 Mayo Foundation For Medical Education And Research Promoter polymorphisms of the blys gene and use in diagnostic methods
US20070105125A1 (en) * 2005-11-08 2007-05-10 Tsai George P Chemical array housing having a gas delivery element and methods of using the same
US7329860B2 (en) 2005-11-23 2008-02-12 Illumina, Inc. Confocal imaging methods and apparatus
US8076074B2 (en) 2005-11-29 2011-12-13 Quest Diagnostics Investments Incorporated Balanced translocation in comparative hybridization
CA2631675A1 (en) * 2005-11-30 2007-06-21 The University Of North Carolina At Chapel Hill Identification of genetic polymorphic variants associated with somatosensory disorders and methods of using the same
US7875274B2 (en) 2005-12-16 2011-01-25 The Board Of Trustees Of The Leland Stanford Junior University Protein modulators of resistance to alkylating agents
US20070161031A1 (en) * 2005-12-16 2007-07-12 The Board Of Trustees Of The Leland Stanford Junior University Functional arrays for high throughput characterization of gene expression regulatory elements
WO2007087113A2 (en) 2005-12-28 2007-08-02 The Scripps Research Institute Natural antisense and non-coding rna transcripts as drug targets
US20070198653A1 (en) * 2005-12-30 2007-08-23 Kurt Jarnagin Systems and methods for remote computer-based analysis of user-provided chemogenomic data
CN101384757A (zh) * 2006-01-03 2009-03-11 哈佛大学校长及研究员协会 小分子印渍
CN101426536A (zh) 2006-01-20 2009-05-06 妇女儿童健康研究院公司 治疗、预防和诊断骨病变的方法
US20070172840A1 (en) * 2006-01-26 2007-07-26 Lin Liu Parallel microarray hybridization
US8138123B2 (en) 2006-01-27 2012-03-20 Takeda Pharmaceutical Company Limited Gene expressing analysis tool
WO2007092314A2 (en) 2006-02-02 2007-08-16 Verenium Corporation Esterases and related nucleic acids and methods
MY160710A (en) 2006-02-10 2017-03-15 Verenium Corp Cellulolytic enzymes, nucleic acids encoding them and methods for making and using them
CA2638801C (en) 2006-02-14 2016-12-13 Verenium Corporation Xylanases, nucleic acids encoding them and methods for making and using them
US8460879B2 (en) * 2006-02-21 2013-06-11 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US11237171B2 (en) 2006-02-21 2022-02-01 Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
KR101622894B1 (ko) 2006-03-07 2016-05-19 바스프 엔자임스 엘엘씨 알돌라제, 이것을 코딩하는 핵산과 그 제조 방법 및 사용 방법
CN101437954B (zh) 2006-03-07 2015-09-09 嘉吉公司 醛缩酶和编码醛缩酶的核酸以及它们的制备和使用方法
US7914988B1 (en) 2006-03-31 2011-03-29 Illumina, Inc. Gene expression profiles to predict relapse of prostate cancer
US20070232556A1 (en) * 2006-03-31 2007-10-04 Montine Thomas J Methods and compositions for the treatment of neurological diseases and disorders
JP5784272B2 (ja) 2006-04-24 2015-09-24 ジェネンテック， インコーポレイテッド 自己免疫性疾患を検出するための方法及び組成物
AU2007244683A1 (en) 2006-04-27 2007-11-08 Pikamab, Inc. Methods and compositions for antibody therapy
BRPI0713098A2 (pt) 2006-05-22 2012-10-16 Clinical Genomics Pty Ltd método para determinar a origem anatÈmica de uma célula ou população celular derivada do intestino grosso de um indivìduo, método de detecção para determinar a origem anatÈmica de uma célula ou população celular derivada do intestino grosso de um indivìduo, sistema de detecção, meio de armazenagem legìvel por computador, arranjo de ácido nucleico, uso de um arranjo, método para determinar o inìcio ou predisposição para o inìcio de uma anormalidade celular ou uma condição destinguida por uma anormalidade celular no intestino grosso, kit de diagnóstico para ensaiar amostras biológicas
US8637436B2 (en) 2006-08-24 2014-01-28 California Institute Of Technology Integrated semiconductor bioarray
US11001881B2 (en) 2006-08-24 2021-05-11 California Institute Of Technology Methods for detecting analytes
EP2489745B1 (en) 2006-06-05 2017-01-11 California Institute Of Technology Real time micro arrays
JP4823310B2 (ja) 2006-06-06 2011-11-24 パナソニック株式会社 ヌクレオチド鎖修飾方法
US7928366B2 (en) * 2006-10-06 2011-04-19 Lam Research Corporation Methods of and apparatus for accessing a process chamber using a dual zone gas injector with improved optical access
US8663577B2 (en) 2006-07-12 2014-03-04 National Institute Of Advanced Industrial Science And Technology Variable pitch array spotter
WO2008008284A2 (en) 2006-07-14 2008-01-17 The Regents Of The University Of California Cancer biomarkers and methods of use threof
US11525156B2 (en) 2006-07-28 2022-12-13 California Institute Of Technology Multiplex Q-PCR arrays
WO2008014485A2 (en) 2006-07-28 2008-01-31 California Institute Of Technology Multiplex q-pcr arrays
CN101528766A (zh) 2006-08-04 2009-09-09 维莱尼姆公司 葡聚糖酶、编码它们的核酸及制备和使用它们的方法
TWI316873B (en) * 2006-08-08 2009-11-11 Ind Tech Res Inst Apparatus of manufacturing biochip and manufacture method of biochip tip array
AU2007284651B2 (en) 2006-08-09 2014-03-20 Institute For Systems Biology Organ-specific proteins and methods of their use
WO2008021431A2 (en) 2006-08-14 2008-02-21 Xdx, Inc. Methods and compositions for diagnosing and monitoring the status of transplant rejection and immune disorders
US11560588B2 (en) 2006-08-24 2023-01-24 California Institute Of Technology Multiplex Q-PCR arrays
US8813764B2 (en) 2009-05-29 2014-08-26 Lam Research Corporation Method and apparatus for physical confinement of a liquid meniscus over a semiconductor wafer
US20100021885A1 (en) * 2006-09-18 2010-01-28 Mark Fielden Reagent sets and gene signatures for non-genotoxic hepatocarcinogenicity
EP2487240B1 (en) 2006-09-19 2016-11-16 Interpace Diagnostics, LLC Micrornas differentially expressed in pancreatic diseases and uses thereof
CA2663962A1 (en) 2006-09-19 2008-03-27 Asuragen, Inc. Mir-15, mir-26, mir-31,mir-145, mir-147, mir-188, mir-215, mir-216, mir-331, mmu-mir-292-3p regulated genes and pathways as targets for therapeutic intervention
JP4692454B2 (ja) * 2006-09-20 2011-06-01 パナソニック株式会社 塗布部材及び塗布方法
US20080076139A1 (en) 2006-09-21 2008-03-27 Sharat Singh Methods and compositions for detecting the activation states of multiple signal transducers in rare circulating cells
MX2009003034A (es) 2006-09-21 2009-11-18 Verenium Corp Fosfolipasas, acidos nucleicos que las codifican, y metodos de hacerlas y usarlas.
EP2617818B1 (en) 2006-09-21 2016-03-23 BASF Enzymes LLC Phytases, nucleic acids encoding them and methods for making and using them
US10753927B2 (en) 2006-09-22 2020-08-25 ALERE TECHNOLOGIES GmbH Methods for detecting an analyte
WO2008034914A2 (en) 2006-09-22 2008-03-27 Clondiag Gmbh A dispenser device for and a method of dispensing a substance onto a substrate
FR2906537A1 (fr) * 2006-09-28 2008-04-04 Biomerieux Sa Procede de diagnostic in vitro du cancer broncho-pulmonaire par detection des transcrits majoritaires alternatifs du gene klk8 codant la kallicreine 8 et son utilisation pour le pronostic de survie
EP2431483B1 (en) 2006-10-20 2015-04-01 Celera Corporation Genetic polymorphisms associated with venous thrombosis, methods of detection and uses thereof
EP1914317A1 (en) * 2006-10-21 2008-04-23 Biolytix AG A method for qualitative and quantitative detection of short nucleic acid sequences of about 8 to 50 nucleotides in length
US8618248B2 (en) 2006-10-31 2013-12-31 President And Fellows Of Harvard College Phosphopeptide compositions and anti-phosphopeptide antibody compositions and methods of detecting phosphorylated peptides
US8148067B2 (en) 2006-11-09 2012-04-03 Xdx, Inc. Methods for diagnosing and monitoring the status of systemic lupus erythematosus
US7741045B2 (en) * 2006-11-16 2010-06-22 General Electric Company Sequential analysis of biological samples
US9201063B2 (en) 2006-11-16 2015-12-01 General Electric Company Sequential analysis of biological samples
US8305579B2 (en) 2006-11-16 2012-11-06 Thomas Pirrie Treynor Sequential analysis of biological samples
US7629125B2 (en) 2006-11-16 2009-12-08 General Electric Company Sequential analysis of biological samples
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
EP2099818A2 (en) 2006-11-29 2009-09-16 Novozymes Inc. Bacillus licheniformis chromosome
JP4307478B2 (ja) * 2006-12-05 2009-08-05 キヤノン株式会社 生化学反応用カートリッジ
US7872018B2 (en) 2006-12-21 2011-01-18 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
DK2479266T3 (en) 2006-12-21 2016-06-20 Basf Enzymes Llc Amylases and glucoamylases, nucleic acids encoding them, and methods of making and using the same
US8146902B2 (en) * 2006-12-21 2012-04-03 Lam Research Corporation Hybrid composite wafer carrier for wet clean equipment
PE20121126A1 (es) * 2006-12-21 2012-08-24 Plexxikon Inc Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa
WO2008079909A1 (en) * 2006-12-21 2008-07-03 Plexxikon, Inc. Pyrrolo [2,3-b] pyridines as kinase modulators
WO2008089449A2 (en) 2007-01-19 2008-07-24 Biodot, Inc. Systems and methods for high speed array printing and hybridization
EP2106439B1 (en) 2007-01-24 2014-11-12 The Regents of the University of Michigan Compositions and methods for treating and diagnosing pancreatic cancer
HUE025408T2 (hu) 2007-01-25 2016-02-29 Hoffmann La Roche IGFBP-7 alkalmazása szívelégtelenség megítélésében
NZ598285A (en) 2007-01-30 2013-10-25 Syngenta Participations Ag Enzymes for the treatment of lignocellulosics, nucleic acids encoding them and methods for making and using them
EP2520668B1 (en) 2007-01-31 2014-12-24 Celera Corporation A molecular prognostic signature for predicting breast cancer distant metastasis, and uses thereof
WO2008112127A2 (en) * 2007-03-08 2008-09-18 Switchgear Genomics Functional arrays for high throughput characterization of regulatory elements in untranslated regions of genes
CN101627306B (zh) * 2007-03-08 2014-02-05 霍夫曼-拉罗奇有限公司 Slim-1在心力衰竭评估中的用途
US20080243865A1 (en) * 2007-03-28 2008-10-02 Oracle International Corporation Maintaining global state of distributed transaction managed by an external transaction manager for clustered database systems
US7975708B2 (en) * 2007-03-30 2011-07-12 Lam Research Corporation Proximity head with angled vacuum conduit system, apparatus and method
US8464736B1 (en) 2007-03-30 2013-06-18 Lam Research Corporation Reclaim chemistry
CA2684801C (en) 2007-04-04 2017-10-10 The Regents Of The University Of California Compositions, devices, systems, and methods for using a nanopore
US8715665B2 (en) 2007-04-13 2014-05-06 The General Hospital Corporation Methods for treating cancer resistant to ErbB therapeutics
US20100255004A1 (en) * 2007-04-13 2010-10-07 Dana Farber Cancer Institute Receptor tyrosine kinase profiling
EP3196310B1 (en) 2007-04-27 2020-07-08 The Regents of The University of California Plant co2 sensors, nucleic acids encoding them, and methods for making and using them
EP2162459B1 (en) * 2007-05-01 2017-10-04 University of Miami Transcriptomic biomarkers for individual risk assessment in new onset heart failure
WO2008137772A1 (en) * 2007-05-04 2008-11-13 Dermtech International Diagnosis of melanoma by nucleic acid analysis
US20100203051A1 (en) 2007-05-31 2010-08-12 The University Of Queensland Diagnostic markers for ankylosing spondylitis and uses thereof
CA2688225C (en) 2007-05-31 2017-09-26 Yale University A genetic lesion associated with cancer
PE20090321A1 (es) 2007-06-04 2009-04-20 Genentech Inc Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica
FR2917090B1 (fr) 2007-06-11 2012-06-15 Biomerieux Sa Reactifs de marquage portant des fonctions diazo et nitro, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques
ES2609818T3 (es) 2007-06-15 2017-04-24 Xiamen University Anticuerpos monoclonales que se unen a hemaglutinina del virus de la gripe aviar del subtipo H5 y usos de los mismos
US8141566B2 (en) * 2007-06-19 2012-03-27 Lam Research Corporation System, method and apparatus for maintaining separation of liquids in a controlled meniscus
PL2173379T3 (pl) 2007-07-02 2016-02-29 Oncomed Pharm Inc Kompozycje oraz sposoby leczenia i diagnozowania nowotworu
ES2567094T3 (es) 2007-07-12 2016-04-19 The Brigham And Women's Hospital, Inc. Composiciones y métodos para diagnosticar y evaluar las miopatías inflamatorias
US20100190777A1 (en) 2007-07-17 2010-07-29 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
EP2676678A1 (en) 2007-07-17 2013-12-25 The General Hospital Corporation Methods to identify and enrich populations of ovarian cancer stem cells and somatic stem cells and uses thereof
US8216784B2 (en) 2007-07-25 2012-07-10 University Of Louisville Research Foundation, Inc. Cancer-derived microvesicle-associated microrna as a diagnostic marker
US7507539B2 (en) * 2007-07-30 2009-03-24 Quest Diagnostics Investments Incorporated Substractive single label comparative hybridization
WO2009021233A2 (en) * 2007-08-09 2009-02-12 Advanced Liquid Logic, Inc. Pcb droplet actuator fabrication
WO2009029073A1 (en) 2007-08-30 2009-03-05 The Trustees Of Tufts College Methods for determining the concentration of an analyte in solution.
US8053198B2 (en) * 2007-09-14 2011-11-08 Meso Scale Technologies, Llc Diagnostic methods
US9388457B2 (en) 2007-09-14 2016-07-12 Affymetrix, Inc. Locus specific amplification using array probes
US20090180931A1 (en) 2007-09-17 2009-07-16 Sequenom, Inc. Integrated robotic sample transfer device
NZ601191A (en) 2007-10-03 2014-01-31 Verenium Corp Xylanases, nucleic acids encoding them and methods for making and using them
AU2008316319A1 (en) 2007-10-23 2009-04-30 Clinical Genomics Pty. Ltd. A method of diagnosing neoplasms
DK2644711T3 (en) 2007-10-23 2018-08-20 Clinical Genomics Pty Ltd A method for diagnosing neoplasms
US8039212B2 (en) 2007-11-05 2011-10-18 Celera Corporation Genetic polymorphisms associated with liver fibrosis, methods of detection and uses thereof
US20090264298A1 (en) * 2007-11-06 2009-10-22 Ambergen, Inc. Methods for enriching subpopulations
US8481263B2 (en) * 2007-11-06 2013-07-09 Ambergen Bead-ligand-nascent protein complexes
US8486634B2 (en) 2007-11-06 2013-07-16 Ambergen, Inc. Amplifying bisulfite-treated template
US8906700B2 (en) 2007-11-06 2014-12-09 Ambergen, Inc. Methods and compositions for phototransfer
US8932879B2 (en) * 2007-11-06 2015-01-13 Ambergen, Inc. Methods and compounds for phototransfer
US20090270278A1 (en) * 2007-11-06 2009-10-29 Ambergen, Inc. Methods and compounds for making arrays
US20090286286A1 (en) * 2007-11-06 2009-11-19 Ambergen , Inc. Methods for controlling amplification
MX2010005080A (es) 2007-11-07 2010-07-28 Genentech Inc Metodos y composiciones para determinar la sensibilidad de linfoma de celula b al tratamiento con anticuerpos anti-cd40.
US20100075374A1 (en) * 2007-11-08 2010-03-25 Ambergen, Inc. Methods for capturing nascent proteins
WO2009067546A2 (en) 2007-11-19 2009-05-28 Celera Corpration Lung cancer markers and uses thereof
US20090131263A1 (en) * 2007-11-19 2009-05-21 Longying Dong Normalization methods for G-protein coupled receptor membrane array
WO2009073511A2 (en) 2007-11-30 2009-06-11 Mayo Foundation For Medical Education And Research Polymorphisms of the blys gene and use in diagnostic methods
US8440425B2 (en) * 2007-12-18 2013-05-14 Abbott Laboratories Method of preparing a biological specimen slide
US20110003708A1 (en) * 2007-12-27 2011-01-06 Compugen Ltd. Biomarkers for the prediction of renal injury
CN104651381A (zh) 2008-01-03 2015-05-27 巴斯夫酶有限责任公司 转移酶和氧化还原酶、编码它们的核酸以及其制备和应用方法
EP2262474B1 (en) 2008-01-30 2019-07-03 Imbed Biosciences, Inc. Methods and compositions for wound healing
CA2618163A1 (en) 2008-02-07 2009-08-07 K. W. Michael Siu Head and neck cancer biomarkers
US20090221620A1 (en) 2008-02-20 2009-09-03 Celera Corporation Gentic polymorphisms associated with stroke, methods of detection and uses thereof
CA2716826C (en) 2008-02-25 2017-05-09 Prometheus Laboratories Inc. Drug selection for breast cancer therapy using antibody-based arrays
US9074244B2 (en) 2008-03-11 2015-07-07 Affymetrix, Inc. Array-based translocation and rearrangement assays
NZ588658A (en) * 2008-03-28 2012-10-26 Mitomics Inc Aberrant mitochondrial dna, associated fusion transcripts and hybridization probes therefor
DE102008018982A1 (de) * 2008-04-14 2009-11-05 Merz, Hartmut, Prof. Dr. med. Automatische Vorrichtung zur Durchführung von Nachweisreaktionen und Verfahren zur Dosierung von Reagenzien auf Objektträgern
US20090260458A1 (en) * 2008-04-17 2009-10-22 Victor Joseph High throughput dispenser
US9017610B2 (en) * 2008-04-25 2015-04-28 Roche Diagnostics Hematology, Inc. Method of determining a complete blood count and a white blood cell differential count
US9602777B2 (en) 2008-04-25 2017-03-21 Roche Diagnostics Hematology, Inc. Systems and methods for analyzing body fluids
EP2274622B1 (en) * 2008-04-30 2014-10-08 The Governing Council of the University of Toronto Use of sfrp-3 in the assessment of heart failure
US20110118125A1 (en) * 2008-05-03 2011-05-19 Tufts Medical Center, Inc. Neonatal salivary genomics
EP2990487A1 (en) 2008-05-08 2016-03-02 Asuragen, INC. Compositions and methods related to mirna modulation of neovascularization or angiogenesis
CN102089444A (zh) 2008-05-14 2011-06-08 德玛泰克国际公司 利用核酸分析方法来诊断黑素瘤和太阳能雀斑
WO2010006215A1 (en) 2008-07-09 2010-01-14 Celera Corporation Genetic polymorphisms associated with cardiovascular diseases, methods of detection and uses thereof
FR2934595B1 (fr) * 2008-07-29 2013-04-05 Biomerieux Sa Reactifs de marquage ayant un noyau pyridine portant une fonction diazomethyle, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques
CA2735710A1 (en) 2008-08-04 2010-02-11 Glen N. Barber Sting (stimulator of interferon genes), a regulator of innate immune responses
US9182406B2 (en) 2008-08-04 2015-11-10 Biodesy, Inc. Nonlinear optical detection of molecules comprising an unnatural amino acid possessing a hyperpolarizability
CA2734521A1 (en) * 2008-08-28 2010-03-04 Dermtech International Determining age ranges of skin samples
US8153391B2 (en) 2008-08-29 2012-04-10 Bunge Oils, Inc. Hydrolases, nucleic acids encoding them and methods for making and using them
US8357503B2 (en) 2008-08-29 2013-01-22 Bunge Oils, Inc. Hydrolases, nucleic acids encoding them and methods for making and using them
US8198062B2 (en) 2008-08-29 2012-06-12 Dsm Ip Assets B.V. Hydrolases, nucleic acids encoding them and methods for making and using them
US8211382B2 (en) 2008-09-22 2012-07-03 Wasatch Microfluidics, Llc Microassay with internal referencing
US20100075862A1 (en) * 2008-09-23 2010-03-25 Quanterix Corporation High sensitivity determination of the concentration of analyte molecules or particles in a fluid sample
US8222047B2 (en) 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays
US20100075439A1 (en) * 2008-09-23 2010-03-25 Quanterix Corporation Ultra-sensitive detection of molecules by capture-and-release using reducing agents followed by quantification
JP5528461B2 (ja) * 2008-10-17 2014-06-25 エフ．ホフマン−ラ ロシュ アーゲー 心不全の評価におけるビグリカンの使用
EP2358912B1 (en) 2008-10-30 2016-10-12 Caris Life Sciences Switzerland Holdings GmbH Methods for assessing rna patterns
US8539905B2 (en) * 2008-11-07 2013-09-24 The Research Foundation For The State University Of New York Polymeric micro-cantilevers for ultra-low volume fluid and living cell deposition
KR101588547B1 (ko) 2008-11-11 2016-01-28 더 리젠츠 오브 더 유니버시티 오브 미시간 항-ｃｘｃｒ１ 조성물 및 방법
GB0820822D0 (en) 2008-11-13 2008-12-24 Inst Catala D Oncologia Novel product and processes
EP2370581B1 (en) 2008-12-04 2016-08-03 CuRNA, Inc. Treatment of vascular endothelial growth factor (vegf) related diseases by inhibition of natural antisense transcript to vegf
KR101866152B1 (ko) 2008-12-04 2018-06-08 큐알엔에이, 인크. 종양 억제 유전자에 대한 천연 안티센스 전사체의 억제에 의해 종양 억제 유전자 관련된 질환의 치료
CN102317458B (zh) 2008-12-04 2018-01-02 库尔纳公司 通过红细胞生成素(epo)天然反义转录物的抑制对epo相关疾病的治疗
WO2010075249A2 (en) 2008-12-22 2010-07-01 Genentech, Inc. A method for treating rheumatoid arthritis with b-cell antagonists
KR20160021308A (ko) 2008-12-23 2016-02-24 제넨테크, 인크. 암 환자에서의 진단 목적용 방법 및 조성물
HUE026280T2 (en) 2009-02-12 2016-06-28 Curna Inc Treatment of brain-derived neurotrophic factor (BDNF) -related diseases by inhibition of natural antisense transcripts associated with BDNF \ t
GB0903168D0 (en) 2009-02-25 2009-04-08 Fusion Antibodies Ltd Diagnostic method and kit
CN105132395A (zh) 2009-03-09 2015-12-09 生物蛋白有限公司 Mirac蛋白
WO2010107733A2 (en) 2009-03-16 2010-09-23 Curna, Inc. Treatment of nuclear factor (erythroid-derived 2)-like 2 (nrf2) related diseases by inhibition of natural antisense transcript to nrf2
JP5904935B2 (ja) 2009-03-17 2016-04-20 クルナ・インコーポレーテッド デルタ様１ホモログ（ｄｌｋ１）に対する天然アンチセンス転写物の抑制によるｄｌｋ１関連疾患の治療
EP3272871B1 (en) 2009-03-27 2020-01-15 MDNA Life Sciences Inc. Aberrant mitochondrial dna, associated fusion transcripts and translation products and hybridization probes therefor
CN105237530A (zh) * 2009-04-03 2016-01-13 豪夫迈罗氏公司 丙烷-1-磺酸{3-[5-(4-氯-苯基)-1H-吡咯并[2,3-b]吡啶-3-羰基]-2,4-二氟-苯基}-酰胺组合物及其用途
US20100297127A1 (en) 2009-04-08 2010-11-25 Ghilardi Nico P Use of il-27 antagonists to treat lupus
US9617600B2 (en) 2009-04-18 2017-04-11 Genentech, Inc. Methods for assessing responsiveness of B-cell lymphoma to treatment with anti-CD40 antibodies
US9085798B2 (en) 2009-04-30 2015-07-21 Prognosys Biosciences, Inc. Nucleic acid constructs and methods of use
US20120046197A1 (en) 2009-05-01 2012-02-23 Meso Scale Technologies, Llc Biomarkers of therapeutic responsiveness
CA2761152A1 (en) 2009-05-06 2010-11-11 Opko Curna, Llc Treatment of lipid transport and metabolism gene related diseases by inhibition of natural antisense transcript to a lipid transport and metabolism gene
ES2609655T3 (es) 2009-05-06 2017-04-21 Curna, Inc. Tratamiento de enfermedades relacionadas con tristetraprolina (TTP) mediante inhibición de transcrito antisentido natural para TTP
KR101742334B1 (ko) 2009-05-08 2017-06-01 큐알엔에이, 인크. Ｄｍｄ 패밀리에 대한 천연 안티센스 전사체의 억제에 의한 디스트로핀 패밀리 관련된 질환의 치료
US20120058916A1 (en) 2009-05-13 2012-03-08 Meso Scale Technologies, Llc. Diagnostic methods for liver disorders
US8957037B2 (en) 2009-05-18 2015-02-17 Curna, Inc. Treatment of reprogramming factor related diseases by inhibition of natural antisense transcript to a reprogramming factor
WO2010135588A2 (en) 2009-05-21 2010-11-25 Verenium Corporation Phytases, nucleic acids encoding them and methods for making and using them
CN102549158B (zh) 2009-05-22 2017-09-26 库尔纳公司 通过抑制针对转录因子e3(tfe3)的天然反义转录物来治疗tfe3和胰岛素受体底物蛋白2(irs2)相关的疾病
EP2435571B1 (en) 2009-05-28 2016-12-14 CuRNA, Inc. Treatment of antiviral gene related diseases by inhibition of natural antisense transcript to an antiviral gene
AU2010254259A1 (en) 2009-05-29 2012-01-12 Emory University B cell signature associated with tolerance in transplant recipients
US20120142544A1 (en) 2009-06-02 2012-06-07 University Of Miami Diagnostic transcriptomic biomarkers in inflammatory cardiomyopathies
EP2264183B1 (en) 2009-06-09 2016-12-07 Gendiag.exe, S.L. Risk markers for cardiovascular disease
CN102695797B (zh) 2009-06-16 2018-05-25 库尔纳公司 通过抑制针对胶原基因的天然反义转录物来治疗胶原基因相关的疾病
KR101702689B1 (ko) 2009-06-16 2017-02-06 큐알엔에이, 인크. Ｐｏｎ1에 대한 천연 안티센스 전사체의 억제에 의한 파라옥소나제 1(ｐｏｎ1) 관련된 질환의 치료
WO2010148115A1 (en) * 2009-06-18 2010-12-23 The Penn State Research Foundation Methods, systems and kits for detecting protein-nucleic acid interactions
CA2765889A1 (en) 2009-06-24 2010-12-29 Opko Curna, Llc Treatment of tumor necrosis factor receptor 2 (tnfr2) related diseases by inhibition of natural antisense transcript to tnfr2
US20120156676A1 (en) 2009-06-25 2012-06-21 Weidhaas Joanne B Single nucleotide polymorphisms in brca1 and cancer risk
EP2446037B1 (en) 2009-06-26 2016-04-20 CuRNA, Inc. Treatment of down syndrome gene related diseases by inhibition of natural antisense transcript to a down syndrome gene
SG10201510152RA (en) 2009-07-13 2016-01-28 Genentech Inc Diagnostic methods and compositions for treatment of cancer
ES2627909T3 (es) 2009-07-15 2017-08-01 Diatech Holdings, Inc. Selección de fármacos para el tratamiento del cáncer gástrico usando matrices basadas en anticuercuerpos
CN102712925B (zh) 2009-07-24 2017-10-27 库尔纳公司 通过抑制sirtuin(sirt)的天然反义转录物来治疗sirtuin(sirt)相关性疾病
CN102549436A (zh) 2009-07-27 2012-07-04 霍夫曼-拉罗奇有限公司 mimecan在评价心力衰竭中的用途
US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
CN102762731B (zh) 2009-08-05 2018-06-22 库尔纳公司 通过抑制针对胰岛素基因(ins)的天然反义转录物来治疗胰岛素基因(ins)相关的疾病
US9689025B2 (en) 2009-08-07 2017-06-27 Nec Solution Innovators, Ltd. Nucleic acid element for use in analysis, and analytical method, analytical reagent, and analytical instrument using same
EP2464731B1 (en) 2009-08-11 2016-10-05 CuRNA, Inc. Treatment of adiponectin (adipoq) related diseases by inhibition of natural antisense transcript to an adiponectin (adipoq)
MX2012001716A (es) 2009-08-14 2012-04-02 Genentech Inc Marcadores biologicos para monitorizar la respuesta del paciente a los antagonistas vegf.
CA2771228C (en) 2009-08-21 2020-12-29 Opko Curna, Llc Treatment of 'c terminus of hsp70-interacting protein' (chip) related diseases by inhibition of natural antisense transcript to chip
US9023822B2 (en) 2009-08-25 2015-05-05 Curna, Inc. Treatment of 'IQ motif containing GTPase activating protein' (IQGAP) related diseases by inhibition of natural antisense transcript to IQGAP
US8815779B2 (en) 2009-09-16 2014-08-26 SwitchGear Genomics, Inc. Transcription biomarkers of biological responses and methods
CA2772670A1 (en) 2009-09-17 2011-03-24 F. Hoffmann-La Roche Ag Methods and compositions for diagnostics use in cancer patients
CN102844443B (zh) 2009-09-21 2014-08-06 保罗·沃尔菲什 用于甲状腺癌诊断和治疗的方法和组合物
CN102630250A (zh) 2009-09-25 2012-08-08 基因诊断测试公司 用于检测与癌症和其他疾病相关的染色体异常的多重(+/-)链阵列和测试
EP2480669B1 (en) 2009-09-25 2017-11-08 CuRNA, Inc. Treatment of filaggrin (flg) related diseases by modulation of flg expression and activity
US9927435B2 (en) 2009-10-15 2018-03-27 Robert Bosch Gmbh Multisite biosensor and associated method
UA109884C2 (uk) 2009-10-16 2015-10-26 Поліпептид, що має активність ферменту фосфатидилінозитол-специфічної фосфоліпази с, нуклеїнова кислота, що його кодує, та спосіб його виробництва і застосування
UA111708C2 (uk) 2009-10-16 2016-06-10 Бандж Ойлз, Інк. Спосіб рафінування олії
EP2491141A2 (en) 2009-10-19 2012-08-29 Stichting Het Nederlands Kanker Instituut Differentiation between brca2-associated tumours and sporadic tumours via array comparative genomic hybridization
WO2011049964A1 (en) 2009-10-19 2011-04-28 Lab Scientific Group Rna detection and quantitation
EP2491139A1 (en) 2009-10-19 2012-08-29 Stichting Het Nederlands Kanker Instituut Predicting benefit of anti-cancer therapy via array comparative genomic hybridization
EP2491140A1 (en) 2009-10-19 2012-08-29 Stichting Het Nederlands Kanker Instituut Predicting response to anti-cancer therapy via array comparative genomic hybridization
JP5819307B2 (ja) 2009-10-20 2015-11-24 ネステク ソシエテ アノニム 発癌性融合タンパク質を検出するための近接媒介性アッセイ
US9677125B2 (en) * 2009-10-21 2017-06-13 General Electric Company Detection of plurality of targets in biological samples
WO2011057022A1 (en) 2009-11-06 2011-05-12 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
JP2013510564A (ja) 2009-11-13 2013-03-28 パンガエア ビオテック、ソシエダッド、リミターダ 肺癌におけるチロシンキナーゼ阻害剤に対する応答を予測するための分子バイオマーカー
CN102712927B (zh) 2009-12-16 2017-12-01 库尔纳公司 通过抑制膜结合转录因子肽酶，位点1(mbtps1)的天然反义转录物来治疗mbtps1相关疾病
HUE027713T2 (en) 2009-12-23 2016-10-28 Hoffmann La Roche Anti-BV8 antibodies and their use
CN102781480B (zh) 2009-12-23 2018-07-27 库尔纳公司 通过抑制解偶联蛋白2(ucp2)的天然反义转录物而治疗ucp2相关疾病
CN102869776B (zh) 2009-12-23 2017-06-23 库尔纳公司 通过抑制肝细胞生长因子(hgf)的天然反义转录物而治疗hgf相关疾病
EP2519633B1 (en) 2009-12-29 2017-10-25 CuRNA, Inc. Treatment of nuclear respiratory factor 1 (nrf1) related diseases by inhibition of natural antisense transcript to nrf1
CN102770540B (zh) 2009-12-29 2017-06-23 库尔纳公司 通过抑制肿瘤蛋白63(p63)的天然反义转录物而治疗p63相关疾病
JP6083735B2 (ja) 2009-12-31 2017-02-22 カッパーアールエヌエー，インコーポレイテッド インスリン受容体基質２（ｉｒｓ２）および転写因子３（ｔｆｅ３）に対する天然アンチセンス転写物の阻害によるインスリン受容体基質２（ｉｒｓ２）関連疾患の治療
EP2519260A2 (en) 2009-12-31 2012-11-07 Deutsches Krebsforschungszentrum Novel modulators of trail signalling
CN102906264B (zh) 2010-01-04 2017-08-04 库尔纳公司 通过抑制干扰素调节因子8(irf8)的天然反义转录物而治疗irf8相关疾病
CN102822342B (zh) 2010-01-06 2017-05-10 库尔纳公司 通过抑制胰腺发育基因的天然反义转录物而治疗胰腺发育基因相关疾病
JP6027893B2 (ja) 2010-01-11 2016-11-16 カッパーアールエヌエー，インコーポレイテッド 性ホルモン結合グロブリン（ｓｈｂｇ）に対する天然アンチセンス転写物の阻害による性ホルモン結合グロブリン（ｓｈｂｇ）関連疾患の治療
MX2012008153A (es) 2010-01-12 2012-11-06 Nestec Sa Metodos para predecir la respuesta a terapia de cancer de mama triple negativo.
US11275084B2 (en) 2010-01-15 2022-03-15 Stanford University Successive sampling device and associated method
JP5691178B2 (ja) * 2010-01-22 2015-04-01 凸版印刷株式会社 分注方法及び分注装置
NO2529015T3 (es) 2010-01-25 2018-04-14
US8648016B2 (en) 2010-02-08 2014-02-11 Robert Bosch Gmbh Array with extended dynamic range and associated method
US8324914B2 (en) 2010-02-08 2012-12-04 Genia Technologies, Inc. Systems and methods for characterizing a molecule
US8962586B2 (en) 2010-02-22 2015-02-24 Curna, Inc. Treatment of pyrroline-5-carboxylate reductase 1 (PYCR1) related diseases by inhibition of natural antisense transcript to PYCR1
US8236574B2 (en) 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
ES2544635T3 (es) 2010-03-01 2015-09-02 Quanterix Corporation Métodos para extender el rango dinámico en ensayos para la detección de moléculas o partículas
US8415171B2 (en) 2010-03-01 2013-04-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
US9678068B2 (en) 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
EP2542678B1 (en) 2010-03-04 2017-04-12 InteRNA Technologies B.V. A MiRNA MOLECULE DEFINED BY ITS SOURCE AND ITS THERAPEUTIC USES IN CANCER ASSOCIATED WITH EMT
EP2553098B1 (en) 2010-04-02 2017-10-11 CuRNA, Inc. Treatment of colony-stimulating factor 3 (csf3) related diseases by inhibition of natural antisense transcript to csf3
PT2556171E (pt) 2010-04-05 2015-12-21 Prognosys Biosciences Inc Ensaios biológicos codificados espacialmente
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
KR101900962B1 (ko) 2010-04-09 2018-09-20 큐알엔에이, 인크. 섬유아세포 성장 인자 21 (ｆｇｆ21)에 대한 자연 안티센스 전사체의 저해에 의한 섬유아세포 성장 인자 21 (ｆｇｆ21) 관련된 질환의 치료
WO2011128096A1 (en) 2010-04-16 2011-10-20 Roche Diagnostics Gmbh Polymorphism markers for predicting response to interleukin-6 receptor-inhibiting monoclonal antibody drug treatment
US20110269735A1 (en) 2010-04-19 2011-11-03 Celera Corporation Genetic polymorphisms associated with statin response and cardiovascular diseases, methods of detection and uses thereof
US10295539B2 (en) 2010-04-19 2019-05-21 Meso Scale Technologies, Llc. Serology assays
US20120003639A1 (en) 2010-04-27 2012-01-05 Prelude, Inc. Cancer biomarkers and methods of use thereof
CA2798218A1 (en) 2010-05-03 2011-11-10 Curna, Inc. Treatment of sirtuin (sirt) related diseases by inhibition of natural antisense transcript to a sirtuin (sirt)
CA2798202A1 (en) 2010-05-04 2011-11-10 Paul Walfish Method for the diagnosis of epithelial cancers by the detection of ep-icd polypeptide
US9188585B2 (en) 2010-05-13 2015-11-17 Robert Bosch Gmbh Device and method for indirect modulation of detection environment
TWI531370B (zh) 2010-05-14 2016-05-01 可娜公司 藉由抑制ｐａｒ４天然反股轉錄本治療ｐａｒ４相關疾病
NO2576783T3 (es) 2010-05-26 2018-04-28
US8980858B2 (en) 2010-05-26 2015-03-17 Curna, Inc. Treatment of methionine sulfoxide reductase a (MSRA) related diseases by inhibition of natural antisense transcript to MSRA
WO2011153224A2 (en) 2010-06-02 2011-12-08 Genentech, Inc. Diagnostic methods and compositions for treatment of cancer
PL2576837T3 (pl) 2010-06-04 2018-04-30 Chronix Biomedical Krążeniowe biomarkery typu kwasu nukleinowego związane z rakiem prostaty
EP2576815B1 (en) 2010-06-04 2018-02-14 Biomérieux Method for the prognosis of colorectal cancer
JP2013529089A (ja) 2010-06-07 2013-07-18 エフ．ホフマン−ラ ロシュ アーゲー インターロイキン−６受容体を阻害するモノクローナル抗体による薬剤治療に対する応答を予測するための遺伝子発現マーカー
US8940310B2 (en) 2010-06-16 2015-01-27 Dynavax Technologies Corporation Methods of treatment using TLR7 and/or TLR9 inhibitors
WO2011159942A1 (en) 2010-06-18 2011-12-22 Illumina, Inc. Conformational probes and methods for sequencing nucleic acids
EP2400304A1 (en) 2010-06-22 2011-12-28 Centro de Investigación Cooperativa En Biomateriales ( CIC biomaGUNE) Method for the characterization of intermolecular interactions
WO2011163499A2 (en) 2010-06-23 2011-12-29 Opko Curna, Llc Treatment of sodium channel, voltage-gated, alpha subunit (scna) related diseases by inhibition of natural antisense transcript to scna
CA2804599C (en) 2010-07-06 2023-01-31 Interna Technologies Bv Mirna and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated braf pathway
ES2663598T3 (es) 2010-07-14 2018-04-16 Curna, Inc. Tratamiento de enfermedades relacionadas con el homólogo de discos grandes (dlg) mediante la inhibición del transcrito antisentido natural a dlg
US9040464B2 (en) 2010-08-16 2015-05-26 Mount Sinai Hosptial Markers of the male urogenital tract
CN103459611B (zh) 2010-09-17 2016-11-02 哈佛大学校长及研究员协会 对多能干细胞的效用和安全性进行表征的功能基因组学研究
US20140018251A1 (en) 2010-09-20 2014-01-16 Stichting Het Nederlands Kanker Instituut Methods for Predicting Response to Anti-Cancer Therapy in Cancer Patients
US9110079B2 (en) 2010-09-29 2015-08-18 Biomerieux Method and kit for establishing an in vitro prognosis on a patient exhibiting SIRS
EP2625268B1 (en) 2010-10-06 2015-12-30 BP Corporation North America Inc. Variant cbh i polypeptides
KR101886457B1 (ko) 2010-10-06 2018-08-07 큐알엔에이, 인크. 시알리다아제 4 (neu4)에 대한 자연 안티센스 전사체의 저해에 의한 neu4 관련된 질환의 치료
EP2630241B1 (en) 2010-10-22 2018-10-17 CuRNA, Inc. Treatment of alpha-l-iduronidase (idua) related diseases by inhibition of natural antisense transcript to idua
US20120108651A1 (en) 2010-11-02 2012-05-03 Leiden University Medical Center (LUMC) Acting on Behalf of Academic Hospital Leiden (AZL) Genetic polymorphisms associated with venous thrombosis and statin response, methods of detection and uses thereof
EP2640851A2 (en) 2010-11-17 2013-09-25 Asuragen, Inc. Mirnas as biomarkers for distinguishing benign from malignant thyroid neoplasms
WO2012068340A2 (en) 2010-11-18 2012-05-24 Opko Curna Llc Antagonat compositions and methods of use
KR102010598B1 (ko) 2010-11-23 2019-08-13 큐알엔에이, 인크. Nanog에 대한 자연 안티센스 전사체의 저해에 의한 nanog 관련된 질환의 치료
US20120302456A1 (en) * 2010-11-23 2012-11-29 President And Fellows Of Harvard College Vertical flow-through devices for multiplexed elisa driven by wicking
JP2014506117A (ja) 2010-11-24 2014-03-13 エフ．ホフマン−ラ ロシュ アーゲー 軽度の炎症を検出するための方法
SG10201510086VA (en) 2010-12-23 2016-01-28 Nestec Sa Drug selection for malignant cancer therapy using antibody-based arrays
EP2657702A4 (en) 2010-12-24 2014-12-03 Nec Solution Innovators Ltd ANALYSIS DEVICE AND ANALYSIS PROCEDURE
EP2474617A1 (en) 2011-01-11 2012-07-11 InteRNA Technologies BV Mir for treating neo-angiogenesis
EP2665557B1 (en) 2011-01-21 2020-01-01 Biodot, Inc. Piezoelectric dispenser with a longitudinal transducer and replaceable capillary tube
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
WO2012106514A2 (en) 2011-02-03 2012-08-09 Pop Test Cortisol Llc System and method for diagnosis and treatment
PT2672967T (pt) 2011-02-07 2018-12-07 Plexxikon Inc Compostos e métodos de modulação da quinase e suas indicações
EP2673728B1 (en) 2011-02-08 2018-09-12 dacadoo ag System, method and apparatus for the remote analysis of chemical compound microarrays
TWI558702B (zh) 2011-02-21 2016-11-21 普雷辛肯公司 醫藥活性物質的固態形式
EP2492688A1 (en) 2011-02-23 2012-08-29 Pangaea Biotech, S.A. Molecular biomarkers for predicting response to antitumor treatment in lung cancer
EP2681566A2 (en) 2011-02-28 2014-01-08 University of Iowa Research Foundation Anti-müllerian hormone changes in pregnancy and prediction ofadverse pregnancy outcomes and gender
CN103415771B (zh) 2011-03-11 2015-04-22 霍夫曼-拉罗奇有限公司 Fen1作为慢性阻塞性肺病(copd)的标志物
WO2012123293A1 (en) 2011-03-11 2012-09-20 Roche Diagnostics Gmbh Seprase as marker for chronic obstructive pulmonary disease (copd)
ES2578477T3 (es) 2011-03-11 2016-07-27 Roche Diagniostics Gmbh ASC como marcador de la enfermedad pulmonar obstructiva crónica (EPOC)
ES2583684T3 (es) 2011-03-11 2016-09-21 F. Hoffmann-La Roche Ag ARMET como marcador de la enfermedad pulmonar obstructiva crónica (EPOC)
ES2583084T3 (es) 2011-03-11 2016-09-19 F. Hoffmann-La Roche Ag NNMT como marcador para la enfermedad pulmonar obstructiva crónica (EPOC)
CN103430027B (zh) 2011-03-11 2015-05-20 霍夫曼-拉罗奇有限公司 Apex1作为慢性阻塞性肺病(copd)的标志物
WO2012129347A1 (en) 2011-03-21 2012-09-27 Biodesy, Llc Classification of kinase inhibitors using nonlinear optical techniques
WO2012130731A1 (en) 2011-03-25 2012-10-04 Roche Diagnostics Gmbh MEASUREMENT OF C-TERMINAL proSP-B
WO2012129758A1 (en) 2011-03-25 2012-10-04 Biomerieux Method and kit for determining in vitro probability for individual to suffer from colorectal cancer
EP2694709B1 (en) 2011-04-08 2016-09-14 Prognosys Biosciences, Inc. Peptide constructs and assay systems
WO2012142301A2 (en) 2011-04-12 2012-10-18 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patients recovery from a brain injury
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
EP2701700A4 (en) 2011-04-27 2015-10-21 Univ Yale Inc PHARMACEUTICAL THERAPY FOR INHIBITING CHEMOTHERAPY-INDUCED SIDE EFFECTS AND CORRESPONDING PHARMACEUTICAL COMPOSITIONS, DIAGNOSTICS, SCREENING METHOD AND KITS
WO2012158957A2 (en) 2011-05-17 2012-11-22 Plexxikon Inc. Kinase modulation and indications therefor
US8778848B2 (en) 2011-06-09 2014-07-15 Illumina, Inc. Patterned flow-cells useful for nucleic acid analysis
US9593330B2 (en) 2011-06-09 2017-03-14 Curna, Inc. Treatment of frataxin (FXN) related diseases by inhibition of natural antisense transcript to FXN
EP2721176A2 (en) 2011-06-17 2014-04-23 Dana-Farber Cancer Institute, Inc. Signatures for predicting the survivability of myelodysplastic syndrome subjects
CN103649741B (zh) 2011-07-04 2016-11-16 日本电气方案创新株式会社 评价核酸分子的氧化还原活性的方法和具有氧化还原活性的核酸分子
KR101851425B1 (ko) 2011-09-02 2018-04-23 네스텍 소시에테아노님 치료 효능 결정을 위한 신호 경로 단백질의 프로파일링
WO2013036403A1 (en) 2011-09-06 2013-03-14 Curna, Inc. TREATMENT OF DISEASES RELATED TO ALPHA SUBUNITS OF SODIUM CHANNELS, VOLTAGE-GATED (SCNxA) WITH SMALL MOLECULES
WO2013040251A2 (en) 2011-09-13 2013-03-21 Asurgen, Inc. Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease
AU2012313353B2 (en) 2011-09-22 2018-03-08 Precision Medicine Holdings Pty Ltd Screening method
WO2013049227A2 (en) 2011-09-26 2013-04-04 Geneart Ag High efficiency, small volume nucleic acid synthesis
WO2014153188A2 (en) 2013-03-14 2014-09-25 Life Technologies Corporation High efficiency, small volume nucleic acid synthesis
DE102011083555B4 (de) 2011-09-27 2013-10-10 Aspre Ag Analyseverfahren und Analysevorrichtung
EP2761294B1 (en) 2011-09-29 2019-02-27 Meso Scale Technologies, LLC Biodosimetry panels and methods
US20140303008A1 (en) 2011-10-21 2014-10-09 Chronix Biomedical Colorectal cancer associated circulating nucleic acid biomarkers
US20130157884A1 (en) 2011-10-26 2013-06-20 Asuragen, Inc. Methods and compositions involving mirna expression levels for distinguishing pancreatic cysts
EP2771487A1 (en) 2011-10-27 2014-09-03 Asuragen, INC. Mirnas as diagnostic biomarkers to distinguish benign from malignant thyroid tumors
AU2012328662B2 (en) 2011-10-28 2015-12-17 Illumina, Inc. Microarray fabrication system and method
US10100092B2 (en) 2011-11-03 2018-10-16 Vca, Inc. Compositions and methods to detect various infectious organisms
US11262362B2 (en) 2011-11-18 2022-03-01 Memorial Sloan-Kettering Cancer Center 2-hydroxyglutarate as a biomarker for chronic hypoxia
EP2783215B1 (en) 2011-11-22 2018-04-25 Robert Bosch GmbH Method for self-referenced confidence test
US8748097B1 (en) 2011-12-02 2014-06-10 President And Fellows Of Harvard College Identification of agents for treating calcium disorders and uses thereof
WO2013087789A1 (en) 2011-12-13 2013-06-20 Glykos Finland Ltd. Antibody isoform arrays and methods thereof
US9850541B2 (en) 2011-12-19 2017-12-26 Valley Health System Methods and kits for detecting subjects at risk of having cancer
EP2795500B1 (en) 2011-12-20 2020-04-15 Siemens Healthcare Diagnostics Inc. Coated substrates for high energy capture phase binding and methods of production and use thereof
US20130164217A1 (en) 2011-12-21 2013-06-27 Meso Scale Technologies, Llc Method of diagnosing, preventing and/or treating dementia & related disorders
WO2013096661A1 (en) 2011-12-22 2013-06-27 Illumina, Inc. Methylation biomarkers for ovarian cancer
WO2013101771A2 (en) 2011-12-30 2013-07-04 Genentech, Inc. Compositions and method for treating autoimmune diseases
EP2802876A1 (en) 2012-01-12 2014-11-19 Robert Bosch GmbH Device and method for indirect electronic condition control in biomolecule detection platforms
RU2659173C2 (ru) 2012-01-13 2018-06-28 Дженентек, Инк. Биологические маркеры для идентификации пациентов для лечения антагонистами vegf
CN104302304A (zh) 2012-02-16 2015-01-21 宾西法利亚州研究基金会 脂酰辅酶a溶血心磷脂酰基转移酶1(alcat1)的调节剂及其用途
CA2865170C (en) 2012-02-21 2020-12-22 Cytonics Corporation Systems, compositions, and methods for transplantation
CA2865541C (en) 2012-02-27 2019-11-05 Toray Industries, Inc. Nucleic acid detection method
HUE040179T2 (hu) 2012-03-15 2019-02-28 Curna Inc Agyi eredetû neutrotróf faktorral (Brain-derived neurotrophic factor, BDNF) összefüggõ betegségek kezelése a BDNF-fel kapcsolatos természetes antiszensz transzkriptumok gátlása révén
EP2829604A4 (en) 2012-03-23 2016-01-27 Nec Solution Innovators Ltd DEVICE FOR THE TARGET ANALYSIS OF STREPTAVIDINE, AND METHOD OF ANALYSIS
WO2013140629A1 (ja) 2012-03-23 2013-09-26 Ｎｅｃソフト株式会社 Ａｔｐまたはａｍｐの分析用デバイスおよび分析方法
CA2867588A1 (en) 2012-03-30 2013-10-03 Genentech, Inc. Diagnostic methods and compositions for treatment of cancer
AU2013243300B2 (en) 2012-04-05 2018-12-06 Oregon Health & Science University Gene expression panel for breast cancer prognosis
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
EP2855425A4 (en) 2012-06-04 2016-05-18 Scripps Research Inst NOVEL PHENYL GLYOXIC STOCKS
US9012022B2 (en) 2012-06-08 2015-04-21 Illumina, Inc. Polymer coatings
CN104704364B (zh) 2012-06-15 2018-12-04 韦恩州立大学 用于先兆子痫和/或hellp综合征的预测或早期检测的生物标记物测试
EP3339861B8 (en) 2012-06-15 2023-11-01 Genesis Theranostix Korlatolt Felelossegu Tarsasag Biomarker test for prediction or early detection of preeclampsia
EP2865764B1 (en) 2012-06-20 2018-09-05 Toray Industries, Inc. Method for detecting nucleic acid and use of a nucleic acid detection kit
US20150152499A1 (en) 2012-07-03 2015-06-04 Interna Technologies B.V. Diagnostic portfolio and its uses
JP2015524397A (ja) 2012-07-20 2015-08-24 ラトローブ ユニヴァーシティ 診断及び処置の方法
JP5959026B2 (ja) 2012-07-27 2016-08-02 Ｎｅｃソリューションイノベータ株式会社 メラミンの分析用核酸センサ、分析用デバイスおよび分析方法
JP6320382B2 (ja) 2012-08-13 2018-05-09 ザ ロックフェラー ユニヴァーシティ メラノーマの処置および診断
US9416403B2 (en) 2012-08-31 2016-08-16 Toray Industries, Inc. Method of detecting target nucleic acid
US10300450B2 (en) 2012-09-14 2019-05-28 Carterra, Inc. Method and device for depositing a substance on a submerged surface
US20140100124A1 (en) 2012-10-04 2014-04-10 Asuragen, Inc. Diagnostic mirnas for differential diagnosis of incidental pancreatic cystic lesions
USRE50065E1 (en) 2012-10-17 2024-07-30 10X Genomics Sweden Ab Methods and product for optimising localised or spatial detection of gene expression in a tissue sample
DE102012020496A1 (de) 2012-10-18 2014-04-24 Charité - Universitätsmedizin Berlin Biomarker zur Diagnostik und Behandlung von Neurofibromatose Typ 1
CN104918659B (zh) 2012-10-31 2019-03-19 洛克菲勒大学 结肠癌的治疗和诊断
JP6334550B2 (ja) 2012-11-06 2018-05-30 インベッド バイオサイエンシズ，インコーポレイテッド 創傷治癒の方法と組成物
PL2925888T3 (pl) 2012-11-28 2018-03-30 Merck Sharp & Dohme Corp. Kompozycje i sposoby do stosowania w leczeniu nowotworów
US9932626B2 (en) 2013-01-15 2018-04-03 Quanterix Corporation Detection of DNA or RNA using single molecule arrays and other techniques
EP2759602A1 (en) 2013-01-25 2014-07-30 Charité - Universitätsmedizin Berlin Non-invasive prenatal genetic diagnostic methods
US20140221325A1 (en) 2013-02-01 2014-08-07 Meso Scale Technologies, Llc Glomerulonephritis biomarkers
US20140221368A1 (en) 2013-02-01 2014-08-07 Meso Scale Technologies, Llc Biomarkers of therapeutic responsiveness
US20140309263A1 (en) 2013-02-01 2014-10-16 Meso Scale Technologies, Llc Biomarkers of therapeutic responsiveness
EP2959014B1 (en) 2013-02-25 2019-11-13 Genentech, Inc. Methods and compositions for detecting and treating drug resistant akt mutant
US9267171B2 (en) 2013-02-28 2016-02-23 New York University DNA photolithography with cinnamate crosslinkers
WO2014136560A1 (ja) 2013-03-08 2014-09-12 Ｎｅｃソリューションイノベータ株式会社 核酸素子候補分子、および、これを用いたターゲット分析用核酸素子のスクリーニング方法
EP3404116B1 (en) 2013-03-15 2022-10-19 The University of Chicago Methods and compositions related to t-cell activity
KR102230831B1 (ko) 2013-03-15 2021-03-22 일루미나 케임브리지 리미티드 변형된 뉴클레오사이드 또는 뉴클레오타이드
EP2971149B1 (en) 2013-03-15 2018-05-09 Baylor Research Institute Ulcerative colitis (uc)-associated colorectal neoplasia markers
US20140274749A1 (en) 2013-03-15 2014-09-18 Affymetrix, Inc. Systems and Methods for SNP Characterization and Identifying off Target Variants
EP2971132B1 (en) 2013-03-15 2020-05-06 Baylor Research Institute Tissue and blood-based mirna biomarkers for the diagnosis, prognosis and metastasis-predictive potential in colorectal cancer
CA2908391A1 (en) 2013-05-01 2014-11-06 Five Prime Therapeutics, Inc. Methods of treating cancer
WO2014187308A2 (zh) 2013-05-21 2014-11-27 生物梅里埃股份公司 一种大肠癌预后试剂盒
JP2016524611A (ja) 2013-05-23 2016-08-18 ファイヴ プライム セラピューティクス インク がんを治療する方法
EP3008229B1 (en) 2013-06-10 2020-05-27 President and Fellows of Harvard College Early developmental genomic assay for characterizing pluripotent stem cell utility and safety
US10208290B2 (en) 2013-06-21 2019-02-19 The Johns Hopkins University Virion display array for profiling functions and interactions of human membrane proteins
DK3013984T3 (da) 2013-06-25 2023-06-06 Prognosys Biosciences Inc Metode til bestemmelse af spatiale mønstre i biologiske targets i en prøve
PT3017065T (pt) 2013-07-01 2018-12-18 Illumina Inc Funcionalização de superfícies sem catalisador e enxerto de polímeros
JP5503062B1 (ja) 2013-07-23 2014-05-28 Ｎｅｃソフト株式会社 ターゲット分析用蛍光センサ、ターゲット分析用キット、およびこれを用いたターゲットの分析方法
US20150038365A1 (en) 2013-08-01 2015-02-05 Meso Scale Technologies, Llc Lung cancer biomarkers
PT3039424T (pt) 2013-08-28 2020-09-03 Crown Bioscience Inc Taicang Assinaturas de expressão genética que permitem prever a resposta de um sujeito a um inibidor multiquinase e métodos de utilização do mesmo
AU2014312249A1 (en) 2013-08-28 2016-03-24 Cytonics Corporation Systems, compositions, and methods for transplantation and treating conditions
US10456470B2 (en) 2013-08-30 2019-10-29 Genentech, Inc. Diagnostic methods and compositions for treatment of glioblastoma
DK3046628T3 (da) 2013-09-19 2020-02-10 Univ Leland Stanford Junior Fremgangsmåder og sammensætninger til fremstilling af hepatocyt-lignende celler
KR20160068802A (ko) 2013-10-23 2016-06-15 제넨테크, 인크. 호산구성 장애를 진단 및 치료하는 방법
CA3171807A1 (en) 2013-12-19 2015-06-25 Illumina, Inc. Substrates comprising nano-patterning surfaces and methods of preparing thereof
CA2935720A1 (en) 2014-01-16 2015-07-23 Illumina, Inc. Gene expression panel for prognosis of prostate cancer recurrence
US10850278B2 (en) 2014-01-29 2020-12-01 Arizona Board Of Regents On Behalf Of Arizona State University Microreactor array platform
CA2975258A1 (en) 2014-01-31 2015-08-06 Temple University Of The Commonwealth System Of Higher Education Bag3 and uses thereof in the treatment of heart failure with reduced ejection fraction
US10261084B1 (en) 2014-02-19 2019-04-16 Stc.Unm Activated GTPase-based assays and kits for the diagnosis of sepsis and other infections
CA2940653A1 (en) 2014-02-27 2015-09-03 Vijay Kuchroo T cell balance gene expression, compositions of matters and methods of use thereof
WO2015161148A1 (en) * 2014-04-18 2015-10-22 Ibis Biosciences, Inc. Uniform deposition of material
KR102246800B1 (ko) 2014-05-13 2021-04-30 바이오아트라, 인코퍼레이티드 조건부 활성 생체 단백질
WO2015187612A1 (en) 2014-06-02 2015-12-10 Valley Health System Method and systems for lung cancer diagnosis
WO2016011052A1 (en) 2014-07-14 2016-01-21 Genentech, Inc. Diagnostic methods and compositions for treatment of glioblastoma
GB201414098D0 (en) 2014-08-08 2014-09-24 Illumina Cambridge Ltd Modified nucleotide linkers
EP3183577B1 (en) 2014-08-21 2020-08-19 Illumina Cambridge Limited Reversible surface functionalization
CA2959141A1 (en) 2014-08-28 2016-03-03 Bioatla, Llc Conditionally active chimeric antigen receptors for modified t-cells
US11111288B2 (en) 2014-08-28 2021-09-07 Bioatla, Inc. Conditionally active chimeric antigen receptors for modified t-cells
AU2015311911B2 (en) 2014-09-03 2019-01-24 Bioatla, Llc Discovering and producing conditionally active biologic proteins in the same eukaryotic cell production hosts
DK3198035T3 (da) 2014-09-26 2023-01-30 Allarity Therapeutics Europe ApS Fremgangsmåder til forudsigelse af medicinrespons
CN107108822B (zh) 2014-10-31 2020-02-07 伊鲁米纳剑桥有限公司 聚合物以及dna共聚物涂层
JP7231326B2 (ja) 2014-11-10 2023-03-01 ジェネンテック， インコーポレイテッド Ｉｌ－３３媒介性障害のための治療及び診断方法
US10683552B2 (en) 2014-11-25 2020-06-16 Presidents And Fellows Of Harvard College Clonal haematopoiesis
EP3224381B1 (en) 2014-11-25 2019-09-04 The Brigham and Women's Hospital, Inc. Method of identifying a person having a predisposition to or afflicted with a cardiometabolic disease
WO2016090323A1 (en) 2014-12-05 2016-06-09 Prelude, Inc. Dcis recurrence and invasive breast cancer
KR102657306B1 (ko) 2014-12-08 2024-04-12 버그 엘엘씨 전립선암의 진단 및 치료에서 필라민을 포함하는 마커의 용도
EP3229959B1 (en) 2014-12-09 2019-05-15 Life Technologies Corporation High efficiency, small volume nucleic acid synthesis
WO2016106286A1 (en) 2014-12-23 2016-06-30 Biodesy, Inc. Attachment of proteins to interfaces for use in nonlinear optical detection
CA2969830A1 (en) 2014-12-24 2016-06-30 Genentech, Inc. Therapeutic, diagnostic and prognostic methods for cancer of the bladder
EP3056904A1 (en) 2015-02-13 2016-08-17 F. Hoffmann-La Roche AG Method of assessing rheumatoid arthritis by measuring anti-CCP and anti-MCM3
EP3056903A1 (en) 2015-02-13 2016-08-17 F. Hoffmann-La Roche AG Method of assessing rheumatoid arthritis by measuring anti-CCP and anti-Casp8
EP3256855B1 (en) 2015-02-13 2020-10-07 Quanterix Corporation Immunoassays for diffrential detection of clostridium difficile
WO2016128348A1 (en) 2015-02-13 2016-08-18 F. Hoffmann-La Roche Ag Method of assessing rheumatoid arthritis by measuring anti-ccp and anti-pik3cd
CN107580603A (zh) 2015-02-24 2018-01-12 生物蛋白有限公司 条件活性生物蛋白
HUE058813T2 (hu) 2015-02-24 2022-09-28 Hope City Kémiailag kódolt térbeli címzésû könyvtárszûrõ platformok
WO2016138488A2 (en) 2015-02-26 2016-09-01 The Broad Institute Inc. T cell balance gene expression, compositions of matters and methods of use thereof
CN104826673B (zh) * 2015-03-16 2017-06-23 中国科学院微生物研究所 写入式二维微流控液滴阵列化装置、用途及其使用方法
US9708647B2 (en) 2015-03-23 2017-07-18 Insilixa, Inc. Multiplexed analysis of nucleic acid hybridization thermodynamics using integrated arrays
WO2016164641A1 (en) 2015-04-08 2016-10-13 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
FI3901281T3 (fi) 2015-04-10 2023-01-31 Biologisten näytteiden spatiaalisesti eroteltu moninkertainen nukleiinihappoanalyysi
WO2016176726A1 (en) 2015-05-01 2016-11-10 Griffith University Diagnostic methods
WO2016196065A1 (en) 2015-05-29 2016-12-08 Genentech, Inc. Methods and compositions for assessing responsiveness of cancers to bet inhibitors
WO2016195982A2 (en) 2015-06-01 2016-12-08 The Penn State Research Foundation Hepatitis b virus capsid assembly
EP3325648B1 (en) 2015-07-17 2023-03-29 Illumina, Inc. Polymer sheets for sequencing applications
US10829484B2 (en) 2015-07-28 2020-11-10 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
US9499861B1 (en) 2015-09-10 2016-11-22 Insilixa, Inc. Methods and systems for multiplex quantitative nucleic acid amplification
EP3347714B1 (en) 2015-09-10 2021-03-10 InSilixa Inc. Methods for multiplex quantitative nucleic acid amplification
EP3141613A1 (en) 2015-09-11 2017-03-15 Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO Detection of quality of surface water
WO2017053838A1 (en) 2015-09-23 2017-03-30 Oklahoma Medical Research Foundation Biomarkers for assessing subjects with multiple sclerosis
AU2016342269A1 (en) 2015-10-22 2018-03-29 Jounce Therapeutics, Inc. Gene signatures for determining icos expression
US9938273B2 (en) 2015-12-07 2018-04-10 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
WO2017155858A1 (en) 2016-03-07 2017-09-14 Insilixa, Inc. Nucleic acid sequence identification using solid-phase cyclic single base extension
US9845499B2 (en) * 2016-04-04 2017-12-19 Combinati Incorporated Microfluidic siphoning array for nucleic acid quantification
US11285478B2 (en) * 2016-04-04 2022-03-29 Combinati Incorporated Microfluidic siphoning array for nucleic acid quantification
US11254742B2 (en) 2016-05-13 2022-02-22 Bioatla, Inc. Anti-Ror2 antibodies, antibody fragments, their immunoconjugates and uses thereof
EP3458913B1 (en) 2016-05-18 2020-12-23 Illumina, Inc. Self assembled patterning using patterned hydrophobic surfaces
EP3512964B1 (en) 2016-09-14 2021-12-15 The U.S.A. as represented by the Secretary, Department of Health and Human Services Methods of diagnosing and treating cd55 deficiency, hyperactivation of complement, angiopathic thrombosis and protein losing enteropathy (chaple), a newly identified orphan disease
TW201815766A (zh) 2016-09-22 2018-05-01 美商普雷辛肯公司 用於ｉｄｏ及ｔｄｏ調節之化合物及方法以及其適應症
US11278629B2 (en) 2016-11-02 2022-03-22 Debiopharm International, S.A. Methods for improving anti-CD37 immunoconjugate therapy
CN110177621B (zh) 2016-11-17 2022-07-08 康比纳提公司 用于核酸分析和定量的方法和系统
EP3558991A2 (en) 2016-12-23 2019-10-30 Plexxikon Inc. Compounds and methods for cdk8 modulation and indications therefor
EP3596117A4 (en) 2017-03-17 2021-01-13 The Johns Hopkins University TARGETED EPIGENETIC THERAPY AGAINST THE DISTAL EXPRESSION REGULATORY ELEMENT OF TGFB2
WO2018177325A1 (en) 2017-03-29 2018-10-04 Crown Bioscience Inc. (Taicang) System and method for determining cetuximab sensitivity on gastric cancer
US20200024351A1 (en) 2017-04-03 2020-01-23 Jounce Therapeutics, Inc. Compositions and Methods for the Treatment of Cancer
US20200131576A1 (en) 2017-04-25 2020-04-30 The Brigham And Women's Hospital, Inc. IL-8, IL-6, IL-1 Beta and TET2 and DNMT3A in Atherosclerosis
CA3063283A1 (en) 2017-05-17 2018-11-22 Microbio Pty Ltd Methods and agents for identifying or classifying microbes based on polymorphisms within ribosomal rna genes
WO2018226846A1 (en) 2017-06-07 2018-12-13 Plexxikon Inc. Compounds and methods for kinase modulation
JP2020532317A (ja) * 2017-07-21 2020-11-12 ジェルミテク バイオアッセイ担体およびその調整
ES2947336T3 (es) 2017-09-01 2023-08-07 Univ Johns Hopkins Terapia epigenética dirigida para el aneurisma aórtico hereditario
WO2019060607A1 (en) 2017-09-20 2019-03-28 Quanterix Corporation METHODS AND SYSTEMS FOR DETECTING MOLECULES OF ANALYTES
AU2018358016A1 (en) 2017-11-03 2020-05-07 Interna Technologies B.V. MiRNA molecule, equivalent, antagomir, or source thereof for treating and/or diagnosing a condition and/or a disease associated with neuronal deficiency or for neuronal (re)generation
WO2019104062A1 (en) 2017-11-21 2019-05-31 Rgenix, Inc. Polymorphs and uses thereof
US11801506B2 (en) * 2018-01-30 2023-10-31 Hewlett-Packard Development Company, L.P. Fluid ejections in nanowells
JP7418337B2 (ja) 2018-02-09 2024-01-19 ジェネンテック， インコーポレイテッド マスト細胞媒介性炎症性疾患の治療法及び診断法
US11976332B2 (en) 2018-02-14 2024-05-07 Dermtech, Inc. Gene classifiers and uses thereof in non-melanoma skin cancers
US20210048431A1 (en) 2018-03-08 2021-02-18 Meso Scale Technologies, Llc. Genetic marker and/or biomarkers for traumatic brain injury, and ultrasensitive assays for biomarkers of traumatic brain injury
EP3844304B1 (en) 2018-08-28 2024-10-02 10X Genomics, Inc. Methods for generating spatially barcoded arrays
EP3844308A1 (en) 2018-08-28 2021-07-07 10X Genomics, Inc. Resolving spatial arrays
US11519033B2 (en) 2018-08-28 2022-12-06 10X Genomics, Inc. Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample
JP2022500504A (ja) 2018-09-14 2022-01-04 プレリュード コーポレーションPrelude Corporation 浸潤性乳癌のリスクを有する対象の治療の選択方法
EP3859009A4 (en) 2018-09-25 2022-08-10 Toray Industries, Inc. METHODS TO EVALUATE THE QUALITY OF A DEPHOSPHORYLATION REAGENT AND METHODS TO DETECT A TARGET NUCLEIC ACID
WO2020067122A1 (ja) 2018-09-25 2020-04-02 東レ株式会社 アルカリホスファターゼ組成物並びに脱リン酸化核酸及び標識化核酸の製造方法
JP7417854B2 (ja) 2018-09-25 2024-01-19 東レ株式会社 アルカリホスファターゼ組成物並びに脱リン酸化核酸及び標識化核酸の製造方法
US11884980B2 (en) 2018-11-28 2024-01-30 Bioscreening & Diagnostics Llc Method for detection of traumatic brain injury
GB2588716B (en) 2018-12-07 2023-11-01 Element Biosciences Inc Flow cell device and use thereof
EP3894587A1 (en) 2018-12-10 2021-10-20 10X Genomics, Inc. Resolving spatial arrays by proximity-based deconvolution
US11293061B2 (en) 2018-12-26 2022-04-05 Illumina Cambridge Limited Sequencing methods using nucleotides with 3′ AOM blocking group
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
CN114174531A (zh) 2019-02-28 2022-03-11 10X基因组学有限公司 用空间条码化寡核苷酸阵列对生物分析物进行概况分析
EP3937780A4 (en) 2019-03-14 2022-12-07 InSilixa, Inc. METHODS AND SYSTEMS FOR TIMED FLUORESCENCE-BASED DETECTION
WO2020190509A1 (en) 2019-03-15 2020-09-24 10X Genomics, Inc. Methods for using spatial arrays for single cell sequencing
WO2020198071A1 (en) 2019-03-22 2020-10-01 10X Genomics, Inc. Three-dimensional spatial analysis
AU2020247911A1 (en) 2019-03-26 2021-11-11 Dermtech, Inc. Novel gene classifiers and uses thereof in skin cancers
US11421271B2 (en) 2019-03-28 2022-08-23 Illumina Cambridge Limited Methods and compositions for nucleic acid sequencing using photoswitchable labels
JP7566775B2 (ja) 2019-04-12 2024-10-15 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 筋肉量及び酸化的代謝を増加させるための組成物及び方法
CA3138566A1 (en) 2019-04-30 2020-11-05 Larimar Therapeutics, Inc. Frataxin-sensitive markers for determining effectiveness of frataxin replacement therapy
WO2020243579A1 (en) 2019-05-30 2020-12-03 10X Genomics, Inc. Methods of detecting spatial heterogeneity of a biological sample
EP4038546B1 (en) 2019-10-01 2024-08-21 10X Genomics, Inc. Systems and methods for identifying morphological patterns in tissue samples
AU2020380282A1 (en) 2019-11-05 2022-05-26 Meso Scale Technologies, Llc. Methods and kits for quantitating radiation exposure
EP4025711A2 (en) 2019-11-08 2022-07-13 10X Genomics, Inc. Enhancing specificity of analyte binding
WO2021091611A1 (en) 2019-11-08 2021-05-14 10X Genomics, Inc. Spatially-tagged analyte capture agents for analyte multiplexing
WO2021097255A1 (en) 2019-11-13 2021-05-20 10X Genomics, Inc. Generating capture probes for spatial analysis
CN115004260A (zh) 2019-11-18 2022-09-02 10X基因组学有限公司 用于组织分类的系统和方法
EP4062373A1 (en) 2019-11-21 2022-09-28 10X Genomics, Inc. Spatial analysis of analytes
CN117746422A (zh) 2019-11-22 2024-03-22 10X基因组学有限公司 使用基准对齐对分析物进行空间分析的系统和方法
US20230021837A1 (en) 2019-11-26 2023-01-26 Meso Scale Technologies, Llc. Methods and kits for detecting autoimmune diseases
EP4065646A1 (en) 2019-11-27 2022-10-05 Illumina Cambridge Limited Cyclooctatetraene containing dyes and compositions
CN114728875A (zh) 2019-12-13 2022-07-08 因思博纳公司 金属盐及其用途
WO2021133842A1 (en) 2019-12-23 2021-07-01 10X Genomics, Inc. Compositions and methods for using fixed biological samples in partition-based assays
EP4424843A3 (en) 2019-12-23 2024-09-25 10X Genomics, Inc. Methods for spatial analysis using rna-templated ligation
US20230089426A1 (en) 2020-01-13 2023-03-23 Jounce Therapeutics, Inc. Methods for the treatment of cancer
US11732299B2 (en) 2020-01-21 2023-08-22 10X Genomics, Inc. Spatial assays with perturbed cells
US11702693B2 (en) 2020-01-21 2023-07-18 10X Genomics, Inc. Methods for printing cells and generating arrays of barcoded cells
US11821035B1 (en) 2020-01-29 2023-11-21 10X Genomics, Inc. Compositions and methods of making gene expression libraries
US12076701B2 (en) 2020-01-31 2024-09-03 10X Genomics, Inc. Capturing oligonucleotides in spatial transcriptomics
US12110541B2 (en) 2020-02-03 2024-10-08 10X Genomics, Inc. Methods for preparing high-resolution spatial arrays
US11898205B2 (en) 2020-02-03 2024-02-13 10X Genomics, Inc. Increasing capture efficiency of spatial assays
US12112833B2 (en) 2020-02-04 2024-10-08 10X Genomics, Inc. Systems and methods for index hopping filtering
US11732300B2 (en) 2020-02-05 2023-08-22 10X Genomics, Inc. Increasing efficiency of spatial analysis in a biological sample
US11835462B2 (en) 2020-02-11 2023-12-05 10X Genomics, Inc. Methods and compositions for partitioning a biological sample
CA3168202A1 (en) 2020-02-21 2021-08-26 Felice Alessio BAVA Methods and compositions for integrated in situ spatial assay
US11891654B2 (en) 2020-02-24 2024-02-06 10X Genomics, Inc. Methods of making gene expression libraries
US11926863B1 (en) 2020-02-27 2024-03-12 10X Genomics, Inc. Solid state single cell method for analyzing fixed biological cells
US11768175B1 (en) 2020-03-04 2023-09-26 10X Genomics, Inc. Electrophoretic methods for spatial analysis
CA3172579A1 (en) 2020-04-15 2021-10-21 David C. Duffy Methods and systems related to highly sensitive assays and by deliveringcapture objects
CN115916999A (zh) 2020-04-22 2023-04-04 10X基因组学有限公司 用于使用靶向rna耗竭进行空间分析的方法
WO2021222827A1 (en) 2020-05-01 2021-11-04 Meso Scale Technologies, Llc. Methods and kits for virus detection
AU2021275906A1 (en) 2020-05-22 2022-12-22 10X Genomics, Inc. Spatial analysis to detect sequence variants
EP4414459A3 (en) 2020-05-22 2024-09-18 10X Genomics, Inc. Simultaneous spatio-temporal measurement of gene expression and cellular activity
WO2021242834A1 (en) 2020-05-26 2021-12-02 10X Genomics, Inc. Method for resetting an array
AU2021283184A1 (en) 2020-06-02 2023-01-05 10X Genomics, Inc. Spatial transcriptomics for antigen-receptors
EP4025692A2 (en) 2020-06-02 2022-07-13 10X Genomics, Inc. Nucleic acid library methods
US12031177B1 (en) 2020-06-04 2024-07-09 10X Genomics, Inc. Methods of enhancing spatial resolution of transcripts
WO2021252499A1 (en) 2020-06-08 2021-12-16 10X Genomics, Inc. Methods of determining a surgical margin and methods of use thereof
EP4165207B1 (en) 2020-06-10 2024-09-25 10X Genomics, Inc. Methods for determining a location of an analyte in a biological sample
JP2023531009A (ja) 2020-06-22 2023-07-20 イルミナ ケンブリッジ リミテッド ３’アセタールブロッキング基を有するヌクレオシド及びヌクレオチド
EP4450639A2 (en) 2020-06-25 2024-10-23 10X Genomics, Inc. Spatial analysis of dna methylation
US11761038B1 (en) 2020-07-06 2023-09-19 10X Genomics, Inc. Methods for identifying a location of an RNA in a biological sample
US11981960B1 (en) 2020-07-06 2024-05-14 10X Genomics, Inc. Spatial analysis utilizing degradable hydrogels
US11981964B2 (en) 2020-07-28 2024-05-14 Illumina Cambridge Limited Substituted coumarin dyes and uses as fluorescent labels
US11981958B1 (en) 2020-08-20 2024-05-14 10X Genomics, Inc. Methods for spatial analysis using DNA capture
WO2022047359A1 (en) 2020-08-31 2022-03-03 Berg Llc Protein biomarkers for pancreatic cancer
US11926822B1 (en) 2020-09-23 2024-03-12 10X Genomics, Inc. Three-dimensional spatial analysis
US11827935B1 (en) 2020-11-19 2023-11-28 10X Genomics, Inc. Methods for spatial analysis using rolling circle amplification and detection probes
US20220195517A1 (en) 2020-12-17 2022-06-23 Illumina Cambridge Limited Long stokes shift chromenoquinoline dyes and uses in sequencing applications
US20220195196A1 (en) 2020-12-17 2022-06-23 Illumina Cambridge Limited Alkylpyridinium coumarin dyes and uses in sequencing applications
US20220195516A1 (en) 2020-12-17 2022-06-23 Illumina Cambridge Limited Methods, systems and compositions for nucleic acid sequencing
AU2021409136A1 (en) 2020-12-21 2023-06-29 10X Genomics, Inc. Methods, compositions, and systems for capturing probes and/or barcodes
US20220195518A1 (en) 2020-12-22 2022-06-23 Illumina Cambridge Limited Methods and compositions for nucleic acid sequencing
US20220228210A1 (en) 2020-12-30 2022-07-21 10X Genomics, Inc. Molecular array generation using photoresist
WO2022147134A1 (en) 2020-12-30 2022-07-07 10X Genomics, Inc. Molecular arrays and methods for generating and using the arrays
US20220314187A1 (en) 2020-12-30 2022-10-06 10X Genomics, Inc. Methods and compositions for light-controlled surface patterning using a polymer
WO2022178267A2 (en) 2021-02-19 2022-08-25 10X Genomics, Inc. Modular assay support devices
EP4301870A1 (en) 2021-03-18 2024-01-10 10X Genomics, Inc. Multiplex capture of gene and protein expression from a biological sample
EP4320440A1 (en) 2021-04-06 2024-02-14 BPGbio, Inc. Protein markers for estrogen receptor (er)-positive luminal a(la)-like and luminal b1 (lb1)-like breast cancer
IL307531A (en) 2021-04-06 2023-12-01 Bpgbio Inc Protein markers for estrogen receptor (ER)-like and estrogen receptor (ER)-negative breast cancer
IL307528A (en) 2021-04-06 2023-12-01 Bpgbio Inc Protein markers for the prognosis of breast cancer progression
JP2024516191A (ja) 2021-05-05 2024-04-12 イルミナ ケンブリッジ リミテッド ビス－ホウ素縮合複素環を含有する蛍光色素及び配列決定における使用
BR112023024130A2 (pt) 2021-05-20 2024-01-30 Illumina Cambridge Ltd Composições e métodos para sequenciamento por síntese
US20220381780A1 (en) 2021-05-21 2022-12-01 Meso Scale Technologies, Llc. Viral strain serology assays
EP4347879A1 (en) 2021-06-03 2024-04-10 10X Genomics, Inc. Methods, compositions, kits, and systems for enhancing analyte capture for spatial analysis
US20230016633A1 (en) 2021-06-15 2023-01-19 Illumina, Inc. Hydrogel-free surface functionalization for sequencing
CN117813391A (zh) 2021-07-23 2024-04-02 因美纳有限公司 制备用于dna测序的基底表面的方法
EP4196605A1 (en) 2021-09-01 2023-06-21 10X Genomics, Inc. Methods, compositions, and kits for blocking a capture probe on a spatial array
WO2023069927A1 (en) 2021-10-20 2023-04-27 Illumina, Inc. Methods for capturing library dna for sequencing
US11820140B2 (en) 2022-03-21 2023-11-21 Funai Electric Co., Ltd Dispense modes for multi-mode capable device
WO2023183764A1 (en) 2022-03-22 2023-09-28 Illumina Cambridge Limited Substrate with orthogonally functional nanodomains
CA3223115A1 (en) 2022-03-28 2023-10-05 Xiaolin Wu Labeled avidin and methods for sequencing
AU2023246772A1 (en) 2022-03-29 2024-01-18 Illumina Inc. Chromenoquinoline dyes and uses in sequencing
WO2023196937A1 (en) 2022-04-06 2023-10-12 Larimar Therapeutics, Inc. Frataxin-sensitive markers for monitoring frataxin replacement therapy
WO2023194369A1 (en) 2022-04-08 2023-10-12 Fundació Institut Mar D'investigacions Mèdiques (Imim) Genetic markers for severe covid-19
US20230383342A1 (en) 2022-05-31 2023-11-30 Illumina Cambridge Limited Compositions and methods for nucleic acid sequencing
WO2023240201A1 (en) 2022-06-08 2023-12-14 Larimar Therapeutics, Inc. Frataxin-sensitive markers for monitoring progression and treatment of leigh syndrome
WO2023245184A1 (en) 2022-06-17 2023-12-21 Meso Scale Technologies, Llc. Viral strain serology assays
WO2024003087A1 (en) 2022-06-28 2024-01-04 Illumina, Inc. Fluorescent dyes containing fused tetracyclic bis-boron heterocycle and uses in sequencing
WO2024006827A1 (en) 2022-06-29 2024-01-04 10X Genomics, Inc. Methods and systems for light-controlled surface patterning using photomasks
EP4405094A1 (en) 2022-06-29 2024-07-31 10X Genomics, Inc. High definition molecular array feature generation using photoresist
WO2024006830A1 (en) 2022-06-29 2024-01-04 10X Genomics, Inc. Methods and compositions for patterned molecular array generation by directed bead delivery
WO2024006799A1 (en) 2022-06-29 2024-01-04 10X Genomics, Inc. Covalent attachment of splint oligonucleotides for molecular array generation using ligation
US20240026444A1 (en) 2022-06-29 2024-01-25 10X Genomics, Inc. Compositions and methods for generating molecular arrays using oligonucleotide printing and photolithography
WO2024006832A1 (en) 2022-06-29 2024-01-04 10X Genomics, Inc. Click chemistry-based dna photo-ligation for manufacturing of high-resolution dna arrays
WO2024006814A1 (en) 2022-06-29 2024-01-04 10X Genomics, Inc. Method of generating arrays using microfluidics and photolithography
US20240076722A1 (en) 2022-06-29 2024-03-07 10X Genomics, Inc. Compositions and methods for oligonucleotide inversion on arrays
EP4376998A1 (en) 2022-06-29 2024-06-05 10X Genomics, Inc. Methods and compositions for refining feature boundaries in molecular arrays
WO2024028794A1 (en) 2022-08-02 2024-02-08 Temple Therapeutics BV Methods for treating endometrial and ovarian hyperproliferative disorders
WO2024039516A1 (en) 2022-08-19 2024-02-22 Illumina, Inc. Third dna base pair site-specific dna detection
WO2024064904A1 (en) 2022-09-23 2024-03-28 Meso Scale Technologies, Llc. Orthopoxvirus serology assays
AU2023348238A1 (en) 2022-09-30 2024-10-03 Illumina, Inc. Compositions and methods for reducing photo damage during sequencing
US20240219835A1 (en) 2022-12-07 2024-07-04 Illumina, Inc. Etch-free photoresist patterning in multi-depth nanowells
WO2024137826A1 (en) 2022-12-21 2024-06-27 10X Genomics, Inc. Analysis of analytes and spatial gene expression
WO2024137765A1 (en) 2022-12-22 2024-06-27 Illumina, Inc. Transition-metal catalyst compositions and methods for sequencing by synthesis
US20240247311A1 (en) 2022-12-22 2024-07-25 Illumina, Inc. Palladium catalyst compositions and methods for sequencing by synthesis
AU2023419253A1 (en) 2022-12-27 2024-10-03 Illumina, Inc. Methods of sequencing using 3´ allyl blocked nucleotides
WO2024145224A1 (en) 2022-12-29 2024-07-04 10X Genomics, Inc. Compositions, methods, and systems for high resolution spatial analysis
US20240327910A1 (en) 2023-03-29 2024-10-03 Illumina, Inc. Naphthalimide dyes and uses in nucleic acid sequencing
US20240327909A1 (en) 2023-03-30 2024-10-03 Illumina, Inc. Compositions and methods for nucleic acid sequencing

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3730844A (en) * 1971-08-27 1973-05-01 Purdue Research Foundation Polynucleotide analysis
FR2353856A1 (fr) * 1976-06-02 1977-12-30 Chateau Guy Ruban destine a servir de support a une reaction par exemple chimique ou biochimique, et procede d'analyse le mettant en oeuvre
US4711955A (en) * 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
FI63596C (fi) * 1981-10-16 1983-07-11 Orion Yhtymae Oy Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser
US4556643A (en) * 1982-07-26 1985-12-03 Agracetus Assay method and probe for polynucleotide sequences
US4591570A (en) * 1983-02-02 1986-05-27 Centocor, Inc. Matrix of antibody-coated spots for determination of antigens
US4677054A (en) * 1983-08-08 1987-06-30 Sloan-Kettering Institute For Cancer Research Method for simple analysis of relative nucleic acid levels in multiple small samples by cytoplasmic dot hybridization
FI71768C (fi) * 1984-02-17 1987-02-09 Orion Yhtymae Oy Foerbaettrade nykleinsyrareagenser och foerfarande foer deras framstaellning.
GB8405437D0 (en) * 1984-03-01 1984-04-04 Amersham Int Plc Detecting polynucleotide sequences
US4670380A (en) * 1984-05-23 1987-06-02 Molecular Diagnostics, Inc. Assays utilizing labeled nucleic acid probes
US4755458A (en) * 1984-08-30 1988-07-05 Enzo Biochem, Inc. Composition and method for the detection of the presence of a polynucleotide sequence of interest
US5064754A (en) * 1984-12-14 1991-11-12 Mills Randell L Genomic sequencing method
US4767700A (en) * 1985-02-15 1988-08-30 Beckman Research Institute Of The City Of Hope Detection of particular nucleotide sequences
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4868104A (en) * 1985-09-06 1989-09-19 Syntex (U.S.A.) Inc. Homogeneous assay for specific polynucleotides
US4868105A (en) * 1985-12-11 1989-09-19 Chiron Corporation Solution phase nucleic acid sandwich assay
US5348855A (en) * 1986-03-05 1994-09-20 Miles Inc. Assay for nucleic acid sequences in an unpurified sample
US4981783A (en) * 1986-04-16 1991-01-01 Montefiore Medical Center Method for detecting pathological conditions
US5202231A (en) * 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
US5100777A (en) * 1987-04-27 1992-03-31 Tanox Biosystems, Inc. Antibody matrix device and method for evaluating immune status
SE458968B (sv) * 1987-06-16 1989-05-22 Wallac Oy Biospecifikt analysfoerfarande foer flera analyter i vilket ingaar partikelraekning och maerkning med fluorescerande maerksubstanser
US4921805A (en) * 1987-07-29 1990-05-01 Life Technologies, Inc. Nucleic acid capture method
GB8810400D0 (en) * 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
US5013669A (en) * 1988-06-01 1991-05-07 Smithkline Diagnostics, Inc. Mass producible biologically active solid phase devices
US5204268A (en) * 1988-06-02 1993-04-20 Fuji Photo Film Co., Ltd. Method and apparatus for applying liquid samples
US5188963A (en) * 1989-11-17 1993-02-23 Gene Tec Corporation Device for processing biological specimens for analysis of nucleic acids
US5185243A (en) * 1988-08-25 1993-02-09 Syntex (U.S.A.) Inc. Method for detection of specific nucleic acid sequences
GB8822228D0 (en) * 1988-09-21 1988-10-26 Southern E M Support-bound oligonucleotides
US5389512A (en) * 1988-10-07 1995-02-14 Hoffman-La Roche Inc. Method for determining the relative amount of a viral nucleic acid segment in a sample by the polymerase chain reaction
US5200051A (en) * 1988-11-14 1993-04-06 I-Stat Corporation Wholly microfabricated biosensors and process for the manufacture and use thereof
US5200312A (en) * 1989-01-30 1993-04-06 The United States Of America As Represented By The Secretary Of The Navy Membrane based dot immunoassay and method of use
US5744101A (en) * 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US6040138A (en) * 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5800992A (en) * 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5242974A (en) * 1991-11-22 1993-09-07 Affymax Technologies N.V. Polymer reversal on solid surfaces
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5252743A (en) * 1989-11-13 1993-10-12 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
US5091652A (en) * 1990-01-12 1992-02-25 The Regents Of The University Of California Laser excited confocal microscope fluorescence scanner and method
EP0455905B1 (en) * 1990-05-11 1998-06-17 Microprobe Corporation Dipsticks for nucleic acid hybridization assays and methods for covalently immobilizing oligonucleotides
US5252296A (en) * 1990-05-15 1993-10-12 Chiron Corporation Method and apparatus for biopolymer synthesis
DE4024545A1 (de) * 1990-08-02 1992-02-06 Boehringer Mannheim Gmbh Verfahren und vorrichtung zum dosierten zufuehren einer biochemischen analysefluessigkeit auf ein target
AU9115891A (en) * 1990-11-14 1992-06-11 Siska Diagnostics, Inc. Non-isotopic detection of nucleic acids using a polystyrene support-based sandwich hybridization assay and compositions useful therefor
DK0834575T3 (da) * 1990-12-06 2002-04-02 Affymetrix Inc A Delaware Corp Identifikation af nucleinsyrer i prøver
WO1992022680A1 (en) * 1991-06-17 1992-12-23 Stauffer John E Improved process for removal of sulfur dioxide from waste gases
US5556748A (en) * 1991-07-30 1996-09-17 Xenopore Corporation Methods of sandwich hybridization for the quantitative analysis of oligonucleotides
US5474796A (en) * 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
US5605662A (en) * 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
US5326691A (en) * 1991-11-21 1994-07-05 John Hozier Micro-libraries and methods of making and manipulating them methods for generating and analyzing micro-libraries
ATE241426T1 (de) * 1991-11-22 2003-06-15 Affymetrix Inc A Delaware Corp Verfahren zur herstellung von polymerarrays
US5412087A (en) * 1992-04-24 1995-05-02 Affymax Technologies N.V. Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces
JPH05236997A (ja) * 1992-02-28 1993-09-17 Hitachi Ltd ポリヌクレオチド捕捉用チップ
ATE205542T1 (de) * 1992-03-04 2001-09-15 Univ California Vergleichende genomhybridisierung
DE69322266T2 (de) * 1992-04-03 1999-06-02 Perkin-Elmer Corp., Foster City, Calif. Proben zusammensetzung und verfahren
US5518883A (en) * 1992-07-02 1996-05-21 Soini; Erkki J. Biospecific multiparameter assay method
WO1995000530A1 (en) * 1993-06-25 1995-01-05 Affymax Technologies N.V. Hybridization and sequencing of nucleic acids
US5512430A (en) * 1993-07-13 1996-04-30 Hri Research, Inc. Diagnostic array for virus infection
US5472842A (en) * 1993-10-06 1995-12-05 The Regents Of The University Of California Detection of amplified or deleted chromosomal regions
EP0730663B1 (en) * 1993-10-26 2003-09-24 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
US5610287A (en) * 1993-12-06 1997-03-11 Molecular Tool, Inc. Method for immobilizing nucleic acid molecules
US5578832A (en) * 1994-09-02 1996-11-26 Affymetrix, Inc. Method and apparatus for imaging a sample on a device
DE69535428T2 (de) * 1994-02-14 2007-12-06 Smithkline Beecham Corp. Verfahren zum Auffinden von differentiel exprimierte Gene
US6015880A (en) * 1994-03-16 2000-01-18 California Institute Of Technology Method and substrate for performing multiple sequential reactions on a matrix
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5795716A (en) * 1994-10-21 1998-08-18 Chee; Mark S. Computer-aided visualization and analysis system for sequence evaluation
US6974666B1 (en) * 1994-10-21 2005-12-13 Appymetric, Inc. Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
US5556752A (en) * 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
US5830645A (en) * 1994-12-09 1998-11-03 The Regents Of The University Of California Comparative fluorescence hybridization to nucleic acid arrays
US5545531A (en) * 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110650688A (zh) * 2017-05-19 2020-01-03 蒂达尔·沙隆 用于收集胃肠道样本的装置和方法
CN110650688B (zh) * 2017-05-19 2023-12-22 恩维沃生物股份有限公司 用于收集胃肠道样本的装置和方法

Also Published As

Publication number Publication date
CA2192005A1 (en) 1998-06-04
DE69509925D1 (de) 1999-07-01
US6110426A (en) 2000-08-29
ES2134481T5 (es) 2012-06-25
DE69509925T3 (de) 2012-07-19
EP0913485A1 (en) 1999-05-06
JPH10503841A (ja) 1998-04-07
JP2002243736A (ja) 2002-08-28
GR3030430T3 (en) 1999-09-30
DK0804731T4 (da) 2012-07-09
CA2192095C (en) 1999-08-31
CA2192095A1 (en) 1995-12-28
JP3272365B2 (ja) 2002-04-08
EP0804731A1 (en) 1997-11-05
ATE180570T1 (de) 1999-06-15
EP0804731B1 (en) 1999-05-26
WO1995035505A1 (en) 1995-12-28
CA2192005C (en) 2005-10-25
DK0804731T3 (da) 1999-11-08
DE69509925T2 (de) 1999-12-09
EP0804731A4 (es) 1997-11-26
EP0804731B2 (en) 2012-05-09
US5807522A (en) 1998-09-15
AU2862995A (en) 1996-01-15
AU709276B2 (en) 1999-08-26

Similar Documents

Publication Publication Date Title
ES2134481T3 (es) Metodo y aparato para producir microconjuntos de muestras biologicas.
EP0834576A3 (en) Methods using nucleic acid hybridization patterns on a matrix of oligonucleotides
EP1959255A3 (en) Closed-loop biochemical analyzers
DE60044490D1 (de) Manipulation von mikroteilchen in mikrofluiden systemen
ATE234154T1 (de) Vorrichtung und verfahren zum durchfuehren von assays
DE69131164D1 (de) Einführung selektiv spaltbarer stellen in oligonukleotidketten und reagenzien dafür
CA2174140A1 (en) Microfabricated, flowthrough porous apparatus for discrete detection of binding reactions
DE3689856D1 (de) Analyseverfahren und vorrichtung für biologische specimen.
EP1391242A3 (en) Microcolumn based high throughput microfluidic device
ES2143680T3 (es) Metodo para caracterizar dna genomico.
ATE407360T1 (de) Verfahren und vorrichtung zur vorbereitung von gewebeproben für parallele analysen
ATE165621T1 (de) Zweiteilige haltevorrichtung aus kunststoff für mit abdeckkappe versehene probenröhrchen
ATE204332T1 (de) Positionelle sequenzierung durch hybridisierung
DE59107805D1 (de) Analyseelement und Verfahren zu seiner Herstellung
PL264696A1 (en) Method for manufacturing polynucleotites and dna and rna probes
DE69131596D1 (de) Dns-abhängige rns-polymerase-transkripte als reportermoleküle zur signalverstärkung in nukleinsäure-hybridisierungsuntersuchungen
ES2147741T3 (es) Sondas de acido nucleico para mycobacterium tuberculosis.
EP0382261A3 (en) Dna probes to vntr loci
DE69030804D1 (de) Reagenzien zur verbesserung von hybridisierung
DE69840725D1 (de) Methode und reagenzien zum bestimmen von substanzen in biologischen proben
DE59704082D1 (de) Verfahren zur durchführung chemischer, insbesondere biochemischer reaktionen und pipettierspitze mit reaktionsgefäss
Belgrader et al. Automated sample processing using robotics for genetic typing of short tandem repeat polymorphisms by capillary electrophoresis
ES2128265A1 (es) Kit genetico para la caracterizacion molecular de la enfermedad de alzheimer.
Bradley Laboratory Profile: What's hot in the Manz lab this summer?
NO875058D0 (no) Oligonukleotidprober og fremgangsmaate for detektering av nukleinsyrene i bakterier og andre levende organismer ved hybridisering.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 804731

Country of ref document: ES