ATE407360T1 - Verfahren und vorrichtung zur vorbereitung von gewebeproben für parallele analysen - Google Patents

Verfahren und vorrichtung zur vorbereitung von gewebeproben für parallele analysen

Info

Publication number
ATE407360T1
ATE407360T1 AT06016017T AT06016017T ATE407360T1 AT E407360 T1 ATE407360 T1 AT E407360T1 AT 06016017 T AT06016017 T AT 06016017T AT 06016017 T AT06016017 T AT 06016017T AT E407360 T1 ATE407360 T1 AT E407360T1
Authority
AT
Austria
Prior art keywords
tumors
hundreds
array
tissue
tissue samples
Prior art date
Application number
AT06016017T
Other languages
English (en)
Inventor
Stephen B Leighton
Juha Kononen
Olli Kallioniemi
Original Assignee
Us Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Health filed Critical Us Health
Application granted granted Critical
Publication of ATE407360T1 publication Critical patent/ATE407360T1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/36—Embedding or analogous mounting of samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/34—Microscope slides, e.g. mounting specimens on microscope slides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
    • G01N1/08—Devices for withdrawing samples in the solid state, e.g. by cutting involving an extracting tool, e.g. core bit
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
    • G01N2001/282—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on with mapping; Identification of areas; Spatial correlated pattern
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/36—Embedding or analogous mounting of samples
    • G01N2001/368—Mounting multiple samples in one block, e.g. TMA [Tissue Microarrays]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Clinical Laboratory Science (AREA)
  • Optics & Photonics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Liquid Deposition Of Substances Of Which Semiconductor Devices Are Composed (AREA)
  • Polymerisation Methods In General (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
AT06016017T 1998-02-25 1999-02-24 Verfahren und vorrichtung zur vorbereitung von gewebeproben für parallele analysen ATE407360T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7597998P 1998-02-25 1998-02-25

Publications (1)

Publication Number Publication Date
ATE407360T1 true ATE407360T1 (de) 2008-09-15

Family

ID=22129137

Family Applications (2)

Application Number Title Priority Date Filing Date
AT06016017T ATE407360T1 (de) 1998-02-25 1999-02-24 Verfahren und vorrichtung zur vorbereitung von gewebeproben für parallele analysen
AT99909585T ATE335199T1 (de) 1998-02-25 1999-02-24 Verfahren und vorrichtung zur erstellung eines arrays für schnelle molekulare profilidentifizierungen

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT99909585T ATE335199T1 (de) 1998-02-25 1999-02-24 Verfahren und vorrichtung zur erstellung eines arrays für schnelle molekulare profilidentifizierungen

Country Status (11)

Country Link
EP (3) EP1980852A1 (de)
JP (2) JP4374139B2 (de)
AT (2) ATE407360T1 (de)
AU (1) AU754047B2 (de)
CA (2) CA2627799A1 (de)
CY (2) CY1105756T1 (de)
DE (2) DE69939503D1 (de)
DK (2) DK1068528T3 (de)
ES (2) ES2272057T3 (de)
PT (2) PT1068528E (de)
WO (1) WO1999044063A2 (de)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6969614B1 (en) * 1999-02-16 2005-11-29 The United States Of America As Represented By The Department Of Health And Human Services Methods for the isolation and analysis of cellular protein content
US6136541A (en) 1999-02-22 2000-10-24 Vialogy Corporation Method and apparatus for analyzing hybridized biochip patterns using resonance interactions employing quantum expressor functions
US6142681A (en) 1999-02-22 2000-11-07 Vialogy Corporation Method and apparatus for interpreting hybridized bioelectronic DNA microarray patterns using self-scaling convergent reverberant dynamics
US6692916B2 (en) 1999-06-28 2004-02-17 Source Precision Medicine, Inc. Systems and methods for characterizing a biological condition or agent using precision gene expression profiles
US6960439B2 (en) 1999-06-28 2005-11-01 Source Precision Medicine, Inc. Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
WO2001020044A2 (en) * 1999-09-17 2001-03-22 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health & Human Services, The National Institutes Of Health Signal counting for in situ hybridization
US6406840B1 (en) 1999-12-17 2002-06-18 Biomosaic Systems, Inc. Cell arrays and the uses thereof
US7003403B1 (en) 2000-06-15 2006-02-21 The United States Of America As Represented By The Department Of Health And Human Services Quantifying gene relatedness via nonlinear prediction of gene
EP1305595A2 (de) 2000-06-22 2003-05-02 Clinomics Laboratories, Inc. Mikroarrays aus eingefrorenem gewebe und verfahren zu ihrer verwendung
AU2001277172A1 (en) * 2000-07-26 2002-02-05 Applied Genomics, Inc. Bstp-trans protein and related reagents and methods of use thereof
AU2001277200A1 (en) * 2000-07-26 2002-02-05 Applied Genomics, Inc. Bstp-cad protein and related reagents and methods of use thereof
WO2002008260A2 (en) * 2000-07-26 2002-01-31 Stanford University Bstp-ecg1 protein and related reagents and methods of use thereof
ATE402760T1 (de) * 2000-08-15 2008-08-15 Bioforce Nanosciences Inc Vorrichtung zur bildung von nanomolekularen netzwerken
WO2002077231A2 (en) * 2000-11-13 2002-10-03 Incyte Genomics, Inc. Nucleic acid-associated proteins
US7171030B2 (en) 2000-11-30 2007-01-30 University Of Medicine & Denistry Of New Jersey Systems for analyzing microtissue arrays
US7079673B2 (en) 2002-02-05 2006-07-18 University Of Medicine & Denistry Of Nj Systems for analyzing microtissue arrays
US6466690C1 (en) 2000-12-19 2008-11-18 Bacus Res Lab Inc Method and apparatus for processing an image of a tissue sample microarray
US6534307B1 (en) 2001-02-08 2003-03-18 Clinomics Biosciences, Inc. Frozen tissue microarrayer
US6716619B1 (en) 2001-02-08 2004-04-06 Clinomics Biosciences, Inc. Stylet for use with tissue microarrayer and molds
AU2002240336A1 (en) * 2001-02-14 2002-08-28 Tularik Inc. Methods for the diagnosis and treatment of tumors employing the hepsin gene
CA2438420A1 (en) * 2001-02-14 2002-08-22 Tularik Inc. Amplified cancer gene wip1
DK1370639T3 (da) * 2001-03-19 2008-05-05 Beecher Instr Instrument til frembringelse af vævsarrays
US6387633B1 (en) * 2001-05-11 2002-05-14 Supratek Pharma, Inc. Method for identifying unstable genes
US6951761B2 (en) 2001-08-31 2005-10-04 The United States Of America As Represented By The Department Of Health And Human Services Measurements of multiple molecules using a CryoArray
WO2003040404A1 (en) 2001-11-09 2003-05-15 Source Precision Medicine, Inc. Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
MXPA04011725A (es) * 2002-05-24 2005-02-14 Monsanto Technology Llc Sistema de descorazonamiento de semillas y metodo para ordenar corazones de semillas para analisis.
HU2464U (en) * 2002-06-25 2003-03-28 Szekeres Gyoergy Dr Hand instrument set for constructing tissue array
US20050112622A1 (en) * 2003-08-11 2005-05-26 Ring Brian Z. Reagents and methods for use in cancer diagnosis, classification and therapy
US8012693B2 (en) 2003-12-16 2011-09-06 3M Innovative Properties Company Analysis of chemically crosslinked cellular samples
JP2007535681A (ja) 2004-04-30 2007-12-06 バイオフォース・ナノサイエンシィズ・インコーポレーテッド 物質を表面上に堆積させるための方法と装置
US7854899B2 (en) 2004-08-26 2010-12-21 The United States Of America As Represented By The Secretary Of Health And Human Services Template methods and devices for preparing sample arrays
EP1792263A2 (de) 2004-09-02 2007-06-06 Vialogy Corporation Erkennung von interessensereignissen unter verwendung von quantenresonanzinterferometrie
US7405056B2 (en) 2005-03-02 2008-07-29 Edward Lam Tissue punch and tissue sample labeling methods and devices for microarray preparation, archiving and documentation
WO2007086915A2 (en) 2005-05-12 2007-08-02 Applied Genomics, Inc. Reagents and methods for use in cancer diagnosis, classification and therapy
CA2652562C (en) 2006-05-17 2015-05-12 Cellumen, Inc. Method for automated tissue analysis
DE102008000036B4 (de) * 2008-01-10 2010-09-30 Leica Biosystems Nussloch Gmbh Verfahren zum Anfertigen histologischer Schnitte und Mikrotom mit einer Aufbring- und Schneideinrichtung
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
JP5629939B2 (ja) * 2010-09-09 2014-11-26 株式会社パソロジー研究所 パイルアップ組織アレイ
CN103221800B (zh) * 2010-11-19 2015-07-15 奥林巴斯株式会社 生物体试样制备方法
ES2739623T3 (es) 2011-03-17 2020-02-03 Cernostics Inc Sistemas y composiciones para diagnosticar el esófago de Barrett y métodos para usarlos
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
DE102011075039A1 (de) * 2011-04-29 2012-10-31 Hamilton Bonaduz Ag Stanzvorrichtung mit beleuchteter Aufnahmeplatte
DE102011075037A1 (de) 2011-04-29 2012-10-31 Hamilton Bonaduz Ag Stanzvorrichtung mit Aufnahmeplatte
WO2013027399A1 (ja) * 2011-08-23 2013-02-28 日本電気株式会社 情報処理システム、情報処理方法、情報処理装置およびその制御方法と制御プログラム
JP2013185920A (ja) * 2012-03-07 2013-09-19 Pathology Institute 組織アレイシートの製造方法およびその製造装置
USRE50065E1 (en) 2012-10-17 2024-07-30 10X Genomics Sweden Ab Methods and product for optimising localised or spatial detection of gene expression in a tissue sample
FR2998823B1 (fr) * 2012-11-30 2015-06-05 Oberthur Technologies Dispositif de decoupe pour test de delaminage
DK3013984T3 (da) 2013-06-25 2023-06-06 Prognosys Biosciences Inc Metode til bestemmelse af spatiale mønstre i biologiske targets i en prøve
JP6367741B2 (ja) * 2015-03-12 2018-08-01 学校法人北里研究所 生体組織標本アレイ切片、生体組織標本アレイ、シート状生体組織標本アレイ、生体組織標本ブロック及びそれらの製造方法
FI3901281T3 (fi) 2015-04-10 2023-01-31 Biologisten näytteiden spatiaalisesti eroteltu moninkertainen nukleiinihappoanalyysi
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
US11821035B1 (en) 2020-01-29 2023-11-21 10X Genomics, Inc. Compositions and methods of making gene expression libraries
US12076701B2 (en) 2020-01-31 2024-09-03 10X Genomics, Inc. Capturing oligonucleotides in spatial transcriptomics
EP4165207B1 (de) 2020-06-10 2024-09-25 10X Genomics, Inc. Verfahren zur bestimmung der position eines analyten in einer biologischen probe
EP4450639A2 (de) 2020-06-25 2024-10-23 10X Genomics, Inc. Räumliche analyse der dna-methylierung
CN116593262B (zh) * 2023-07-13 2023-09-26 南京普恩瑞生物科技有限公司 基于pdx/pdtx肿瘤活组织生物样本和数据库的分子标志物检测产品及其制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2563343B1 (fr) * 1984-04-19 1986-06-13 Rhone Poulenc Sante Dispositif pour effectuer des prelevements dans des milieux semi-solides
IT8521051V0 (it) * 1985-03-08 1985-03-08 Lepetit Spa Formatore di pozzetti.
US4820504A (en) * 1986-02-12 1989-04-11 City Of Hope Multi-specimen tissue blocks and slides
GB8626920D0 (en) * 1986-11-11 1986-12-10 Gadson D R Examination of multiple samples for analysis
US4914022A (en) * 1987-10-21 1990-04-03 Amc Cancer Research Center Method for preparing multiple tissue samples for microscopic investigation and testing
EP0332322A2 (de) * 1988-02-26 1989-09-13 Elsevier Science Publishing Co., Inc. Datenerfassungs, speicherungs-und verarbeitungsssystem
US5002377A (en) 1988-07-07 1991-03-26 City Of Hope Multi-specimen slides for immunohistologic procedures
JPH0835921A (ja) * 1994-07-22 1996-02-06 Kanagawa Kagaku Gijutsu Akad 試料ブロック及びその自動検査装置
ATE319986T1 (de) * 1997-09-11 2006-03-15 Bioventures Inc Verfahren zur herstellung von arrays hoher dichte

Also Published As

Publication number Publication date
JP2002505432A (ja) 2002-02-19
EP1715340B1 (de) 2008-09-03
CY1105756T1 (el) 2010-12-22
WO1999044063B1 (en) 1999-12-02
EP1980852A1 (de) 2008-10-15
WO1999044063A3 (en) 1999-11-04
DE69932607D1 (de) 2006-09-14
AU2875799A (en) 1999-09-15
CA2627799A1 (en) 1999-09-02
DK1715340T3 (da) 2009-01-26
JP2009244269A (ja) 2009-10-22
PT1068528E (pt) 2006-12-29
ES2272057T3 (es) 2007-04-16
EP1715340A3 (de) 2006-11-29
EP1068528B1 (de) 2006-08-02
WO1999044063A2 (en) 1999-09-02
EP1715340A2 (de) 2006-10-25
DK1068528T3 (da) 2006-11-27
DE69932607T2 (de) 2007-10-25
PT1715340E (pt) 2008-12-16
CA2318984C (en) 2009-04-28
DE69939503D1 (de) 2008-10-16
EP1068528A2 (de) 2001-01-17
ES2317380T3 (es) 2009-04-16
ATE335199T1 (de) 2006-08-15
CY1108634T1 (el) 2014-04-09
JP4374139B2 (ja) 2009-12-02
CA2318984A1 (en) 1999-09-02
AU754047B2 (en) 2002-10-31

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