PT1715340E - Método e aparelho para preparar uma série para o estabelecimento rápido de perfis moleculares - Google Patents

Método e aparelho para preparar uma série para o estabelecimento rápido de perfis moleculares Download PDF

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Publication number
PT1715340E
PT1715340E PT06016017T PT06016017T PT1715340E PT 1715340 E PT1715340 E PT 1715340E PT 06016017 T PT06016017 T PT 06016017T PT 06016017 T PT06016017 T PT 06016017T PT 1715340 E PT1715340 E PT 1715340E
Authority
PT
Portugal
Prior art keywords
tumors
hundreds
tissue specimens
array
tissue
Prior art date
Application number
PT06016017T
Other languages
English (en)
Inventor
Juha Kononen
Olli Kallioniemi
Stephen B Leighton
Original Assignee
Us Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Health filed Critical Us Health
Publication of PT1715340E publication Critical patent/PT1715340E/pt

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Rigid containers without fluid transport within
    • B01L3/5085—Rigid containers without fluid transport within for multiple samples, e.g. microtitration plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/36—Embedding or analogous mounting of samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/34—Microscope slides, e.g. mounting specimens on microscope slides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
    • G01N1/08—Devices for withdrawing samples in the solid state, e.g. by cutting involving an extracting tool, e.g. core bit
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
    • G01N2001/282—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on with mapping; Identification of areas; Spatial correlated pattern
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/36—Embedding or analogous mounting of samples
    • G01N2001/368—Mounting multiple samples in one block, e.g. TMA [Tissue Microarrays]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Clinical Laboratory Science (AREA)
  • Optics & Photonics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Liquid Deposition Of Substances Of Which Semiconductor Devices Are Composed (AREA)
  • Polymerisation Methods In General (AREA)
PT06016017T 1998-02-25 1999-02-24 Método e aparelho para preparar uma série para o estabelecimento rápido de perfis moleculares PT1715340E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7597998P 1998-02-25 1998-02-25

Publications (1)

Publication Number Publication Date
PT1715340E true PT1715340E (pt) 2008-12-16

Family

ID=22129137

Family Applications (2)

Application Number Title Priority Date Filing Date
PT99909585T PT1068528E (pt) 1998-02-25 1999-02-24 Método e aparato para reparar uma série para o estabelecimento rápido de perfis moleculares
PT06016017T PT1715340E (pt) 1998-02-25 1999-02-24 Método e aparelho para preparar uma série para o estabelecimento rápido de perfis moleculares

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PT99909585T PT1068528E (pt) 1998-02-25 1999-02-24 Método e aparato para reparar uma série para o estabelecimento rápido de perfis moleculares

Country Status (11)

Country Link
EP (3) EP1068528B1 (pt)
JP (2) JP4374139B2 (pt)
AT (2) ATE407360T1 (pt)
AU (1) AU754047B2 (pt)
CA (2) CA2318984C (pt)
CY (2) CY1105756T1 (pt)
DE (2) DE69932607T2 (pt)
DK (2) DK1715340T3 (pt)
ES (2) ES2317380T3 (pt)
PT (2) PT1068528E (pt)
WO (1) WO1999044063A2 (pt)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6969614B1 (en) * 1999-02-16 2005-11-29 The United States Of America As Represented By The Department Of Health And Human Services Methods for the isolation and analysis of cellular protein content
US6136541A (en) 1999-02-22 2000-10-24 Vialogy Corporation Method and apparatus for analyzing hybridized biochip patterns using resonance interactions employing quantum expressor functions
US6142681A (en) 1999-02-22 2000-11-07 Vialogy Corporation Method and apparatus for interpreting hybridized bioelectronic DNA microarray patterns using self-scaling convergent reverberant dynamics
US6692916B2 (en) 1999-06-28 2004-02-17 Source Precision Medicine, Inc. Systems and methods for characterizing a biological condition or agent using precision gene expression profiles
US6960439B2 (en) 1999-06-28 2005-11-01 Source Precision Medicine, Inc. Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
WO2001020044A2 (en) * 1999-09-17 2001-03-22 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health & Human Services, The National Institutes Of Health Signal counting for in situ hybridization
US6406840B1 (en) 1999-12-17 2002-06-18 Biomosaic Systems, Inc. Cell arrays and the uses thereof
US7003403B1 (en) 2000-06-15 2006-02-21 The United States Of America As Represented By The Department Of Health And Human Services Quantifying gene relatedness via nonlinear prediction of gene
JP2004500891A (ja) 2000-06-22 2004-01-15 クリノミクス　バイオサイエンシズ，インク． 凍結組織マイクロアレイ及びその使用法
WO2002008260A2 (en) * 2000-07-26 2002-01-31 Stanford University Bstp-ecg1 protein and related reagents and methods of use thereof
WO2002008281A2 (en) * 2000-07-26 2002-01-31 Stanford University Bstp-cad protein and related reagents and methods of use thereof
WO2002008765A2 (en) * 2000-07-26 2002-01-31 Stanford University Basal cell markers in breast cancer and uses thereof
DE60135150D1 (de) * 2000-08-15 2008-09-11 Bioforce Nanosciences Inc Vorrichtung zur bildung von nanomolekularen netzwerken
WO2002077231A2 (en) * 2000-11-13 2002-10-03 Incyte Genomics, Inc. Nucleic acid-associated proteins
US7171030B2 (en) 2000-11-30 2007-01-30 University Of Medicine & Denistry Of New Jersey Systems for analyzing microtissue arrays
US7079673B2 (en) 2002-02-05 2006-07-18 University Of Medicine & Denistry Of Nj Systems for analyzing microtissue arrays
US6466690C1 (en) 2000-12-19 2008-11-18 Bacus Res Lab Inc Method and apparatus for processing an image of a tissue sample microarray
US6534307B1 (en) 2001-02-08 2003-03-18 Clinomics Biosciences, Inc. Frozen tissue microarrayer
US6716619B1 (en) 2001-02-08 2004-04-06 Clinomics Biosciences, Inc. Stylet for use with tissue microarrayer and molds
WO2002064838A2 (en) * 2001-02-14 2002-08-22 Tularik Inc. Amplified cancer gene wip1
CA2438433A1 (en) * 2001-02-14 2002-08-22 Tularik Inc. Methods for the diagnosis and treatment of tumors employing the hepsin gene
WO2003010280A1 (en) * 2001-03-19 2003-02-06 Beecher Instruments Tissue array instrument
US6387633B1 (en) * 2001-05-11 2002-05-14 Supratek Pharma, Inc. Method for identifying unstable genes
US6951761B2 (en) 2001-08-31 2005-10-04 The United States Of America As Represented By The Department Of Health And Human Services Measurements of multiple molecules using a CryoArray
CN1612936A (zh) 2001-11-09 2005-05-04 苏尔斯精细医药公司 利用基因表达分布图识别、监控和治疗疾病以及鉴定生物学状态
AU2003233650A1 (en) 2002-05-24 2003-12-12 Monsanto Technology Llc. Seed coring system and method for arranging seed cores for analysis
HU2464U (en) * 2002-06-25 2003-03-28 Szekeres Gyoergy Dr Hand instrument set for constructing tissue array
WO2004060044A2 (en) 2003-01-02 2004-07-22 Bioforce Nanosciences, Inc. Method and apparatus for molecular analysis in small sample volumes
US20050112622A1 (en) * 2003-08-11 2005-05-26 Ring Brian Z. Reagents and methods for use in cancer diagnosis, classification and therapy
US8012693B2 (en) 2003-12-16 2011-09-06 3M Innovative Properties Company Analysis of chemically crosslinked cellular samples
US7690325B2 (en) 2004-04-30 2010-04-06 Bioforce Nanosciences, Inc. Method and apparatus for depositing material onto a surface
US7854899B2 (en) 2004-08-26 2010-12-21 The United States Of America As Represented By The Secretary Of Health And Human Services Template methods and devices for preparing sample arrays
EP1792263A2 (en) 2004-09-02 2007-06-06 Vialogy Corporation Detecting events of interest using quantum resonance interferometry
US7405056B2 (en) 2005-03-02 2008-07-29 Edward Lam Tissue punch and tissue sample labeling methods and devices for microarray preparation, archiving and documentation
US7504225B2 (en) 2005-05-12 2009-03-17 Applied Genomics, Inc. Reagents and methods for use in cancer diagnosis, classification and therapy
CN101484806A (zh) 2006-05-17 2009-07-15 协乐民公司 一种对组织进行自动分析的方法
DE102008000036B4 (de) * 2008-01-10 2010-09-30 Leica Biosystems Nussloch Gmbh Verfahren zum Anfertigen histologischer Schnitte und Mikrotom mit einer Aufbring- und Schneideinrichtung
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
JP5629939B2 (ja) * 2010-09-09 2014-11-26 株式会社パソロジー研究所 パイルアップ組織アレイ
EP2629078B1 (en) * 2010-11-19 2019-04-17 Olympus Corporation Method for preparing biological sample
ES2739623T3 (es) 2011-03-17 2020-02-03 Cernostics Inc Sistemas y composiciones para diagnosticar el esófago de Barrett y métodos para usarlos
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
DE102011075037A1 (de) 2011-04-29 2012-10-31 Hamilton Bonaduz Ag Stanzvorrichtung mit Aufnahmeplatte
DE102011075039A1 (de) * 2011-04-29 2012-10-31 Hamilton Bonaduz Ag Stanzvorrichtung mit beleuchteter Aufnahmeplatte
US20140193052A1 (en) * 2011-08-23 2014-07-10 Yoshiko Yoshihara Information processing system, information processing method, information processing apparatus, control method thereof and control program
JP2013185920A (ja) * 2012-03-07 2013-09-19 Pathology Institute 組織アレイシートの製造方法およびその製造装置
EP3901280B1 (en) 2012-10-17 2025-03-12 10x Genomics Sweden AB Methods and product for optimising localised or spatial detection of gene expression in a tissue sample
FR2998823B1 (fr) * 2012-11-30 2015-06-05 Oberthur Technologies Dispositif de decoupe pour test de delaminage
CN111500680B (zh) 2013-06-25 2024-04-16 普罗格诺西斯生物科学公司 检测样品中生物靶标的空间分布的方法和系统
JP6367741B2 (ja) * 2015-03-12 2018-08-01 学校法人北里研究所 生体組織標本アレイ切片、生体組織標本アレイ、シート状生体組織標本アレイ、生体組織標本ブロック及びそれらの製造方法
EP4321627A3 (en) 2015-04-10 2024-04-17 10x Genomics Sweden AB Spatially distinguished, multiplex nucleic acid analysis of biological specimens
EP3894585A2 (en) 2018-12-10 2021-10-20 10X Genomics, Inc. Generating capture probes for spatial analysis
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
US11821035B1 (en) 2020-01-29 2023-11-21 10X Genomics, Inc. Compositions and methods of making gene expression libraries
US12076701B2 (en) 2020-01-31 2024-09-03 10X Genomics, Inc. Capturing oligonucleotides in spatial transcriptomics
EP4446430A3 (en) 2020-06-10 2024-12-18 10X Genomics, Inc. Methods for determining a location of an analyte in a biological sample
EP4450639B1 (en) 2020-06-25 2025-10-15 10X Genomics, Inc. Spatial analysis of dna methylation
CN116593262B (zh) * 2023-07-13 2023-09-26 南京普恩瑞生物科技有限公司 基于pdx/pdtx肿瘤活组织生物样本和数据库的分子标志物检测产品及其制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2563343B1 (fr) * 1984-04-19 1986-06-13 Rhone Poulenc Sante Dispositif pour effectuer des prelevements dans des milieux semi-solides
IT8521051U1 (it) * 1985-03-08 1986-09-08 Lepetit Spa Formatore di pozzetti.
US4820504A (en) * 1986-02-12 1989-04-11 City Of Hope Multi-specimen tissue blocks and slides
GB8626920D0 (en) * 1986-11-11 1986-12-10 Gadson D R Examination of multiple samples for analysis
US4914022A (en) 1987-10-21 1990-04-03 Amc Cancer Research Center Method for preparing multiple tissue samples for microscopic investigation and testing
EP0332322A2 (en) * 1988-02-26 1989-09-13 Elsevier Science Publishing Co., Inc. Data creating, storage and processing system
US5002377A (en) * 1988-07-07 1991-03-26 City Of Hope Multi-specimen slides for immunohistologic procedures
JPH0835921A (ja) * 1994-07-22 1996-02-06 Kanagawa Kagaku Gijutsu Akad 試料ブロック及びその自動検査装置
IL134702A (en) * 1997-09-11 2004-03-28 Bioventures Inc High density arrays and methods of making the same

Also Published As

Publication number Publication date
JP2009244269A (ja) 2009-10-22
ATE335199T1 (de) 2006-08-15
WO1999044063A2 (en) 1999-09-02
CA2627799A1 (en) 1999-09-02
PT1068528E (pt) 2006-12-29
ES2272057T3 (es) 2007-04-16
EP1068528B1 (en) 2006-08-02
AU2875799A (en) 1999-09-15
WO1999044063B1 (en) 1999-12-02
EP1715340B1 (en) 2008-09-03
DE69939503D1 (de) 2008-10-16
DK1715340T3 (da) 2009-01-26
CA2318984A1 (en) 1999-09-02
CY1108634T1 (el) 2014-04-09
EP1068528A2 (en) 2001-01-17
ATE407360T1 (de) 2008-09-15
JP2002505432A (ja) 2002-02-19
DK1068528T3 (da) 2006-11-27
DE69932607T2 (de) 2007-10-25
EP1715340A2 (en) 2006-10-25
CY1105756T1 (el) 2010-12-22
CA2318984C (en) 2009-04-28
JP4374139B2 (ja) 2009-12-02
EP1715340A3 (en) 2006-11-29
DE69932607D1 (de) 2006-09-14
EP1980852A1 (en) 2008-10-15
AU754047B2 (en) 2002-10-31
ES2317380T3 (es) 2009-04-16
WO1999044063A3 (en) 1999-11-04

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